Okayama University

2023.4 - 2025.3

Okayama University

2021.4 - 2023.3

Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Professor

2005.10

名古屋大学（医学部）   助教授

1999.4 - 2005.9

名古屋大学（医学部）   講師

1994.4

名古屋大学（医学部）   助手

1993.4 - 1994.3

長寿科学振興財団   リサーチレジデント

1992.4 - 1993.3

ノースカロライナ大学チャペルヒル校   Research Fellow

1989.5 - 1990.6

日本生体医工学会

日本医史学会

日本産科婦人科学会

日本生物物理学会

日本生理学会

  岡山県医師会（産業保健担当理事）  

2021.4   

公益財団法人鈴木謙三記念医科学応用研究財団　   調査研究助成選考委員  

2021.4 - 2023.3   

JST戦略的創造研究推進事業 総括実施型研究（ＥＲＡＴＯ）   パネルメンバー  

2021.4 - 2022.3   

国立研究開発法人科学技術振興機構   創発的研究支援事業アドバイザー  

2020.9 - 2023.3   

公益社団法人日本生体医工学会   副理事長  

2020.6 - 2022.6   

一般社団法人日本生理学会   副理事長  

2020.3 - 2024   

公益社団法人日本生体医工学会   理事  

2018.4   

岡山県医用工学研究会   会長  

2018.4   

Ligand-independent function of β2-adrenergic receptor affects IgE-mediated Ca2+ influx in mast cells Reviewed

Nagao K, Yoshikawa S, Urakami H, Fujita Y, Komura A, Nakashima M, Oh-Hora M, Fujimura A, Hiyama TY, Naruse K, Morizane S, Tominaga M, Takamori K, Miyake S

Biochemical and Biophysical Research Communications   733   150595 - 150595   2024.11

Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes Reviewed International journal

Yamada H, Osaka H, Tatsumi N, Araki M, Abe T, Kaihara K, Takahashi K, Takashima E, Uchihashi T, Naruse K, Takei K

Cells   13 ( 16 )   1373 - 1373   2024.8

Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes Reviewed

Liu Y, Kamran R, Han X, Wang M, Li Q, Lai D, Naruse K, Takahashi K

Scientific Reports   14 ( 1 )   18063   2024.8

Celiac and superior mesenteric ganglia removal improves glucose tolerance and reduces pancreas islet size Reviewed

Xu S, Inoue M, Yoshimura Y, Kondoh K, Naruse K, Hiyama TY

Neuroscience Letters   837   137919 - 137919   2024.8

Development of lung tissue models and their applications Reviewed

Nalinrat Petpiroon, Woranan Netkueakul, Kanokwan Sukrak, Chen Wang, Yin Liang, Mengxue Wang, Yun Liu, Qiang Li, Rumaisa Kamran, Keiji Naruse, Sasitorn Aueviriyavit, Ken Takahashi

Life Sciences   334   122208 - 122208   2023.12

Stretch‐induced reactive oxygen species contribute to the Frank–Starling mechanism Reviewed

Kaihara K, Kai H, Chiba Y, Naruse K, Iribe G

The Journal of Physiology   2023.4

High hydrostatic pressure induces slow contraction in mouse cardiomyocytes Reviewed

Yamaguchi Y, Nishiyama M, Kai H, Kaneko T, Kaihara K, Iribe G, Takai A, Naruse K, Morimatsu M

Biophysical Journal   122 ( 1 )   267 - 267   2023.1

Live imaging of nitric oxide release in vascular endothelial cells in response to mechanical stimuli on an organ chip Reviewed

Takahashi K, Liu Y, Wang M, Liang Y, Naruse K

European Heart Journal   43 ( Supplement_22 )   2022.10

High hydrostatic pressure induces slow contraction in mouse cardiomyocytes. Reviewed International journal

Yamaguchi Y, Nishiyama M, Kai H, Kaneko T, Kaihara K, Iribe G, Takai A, Naruse K, Morimatsu M

Biophysical journal   2022.7

Gravity sensing in plant and animal cells Reviewed

Takahashi K, Takahashi H, Furuichi T, Toyota M, Furutani-Seiki M, Kobayashi T, Watanabe-Takano H, Shinohara M, Numaga-Tomita T, Sakaue-Sawano A, Miyawaki A, Naruse K

npj Microgravity   7 ( 1 )   2   2021.12

Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells Reviewed

Liu Y, Wang M, Liang Y, Naruse K, Takahashi K

European Heart Journal   42 ( Supplement_11 )   2021.10

Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells Reviewed

Yin Liang, Mengxue Wang, Yun Liu, Chen Wang, Ken Takahashi, Keiji Naruse

Frontiers in Cell and Developmental Biology   9   689662   2021.8

Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress Reviewed

Chen Wang, Jian Chen, Mengxue Wang, Keiji Naruse, Ken Takahashi

Biochemical and Biophysical Research Communications   566   190 - 196   2021.8

Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage. Reviewed International journal

Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T

Arthritis & rheumatology (Hoboken, N.J.)   73 ( 8 )   1441 - 1450   2021.8

Production of TRPM4 knockout cell line using rat cardiomyocyte H9c2 Reviewed

Chen Wang, Masakazu Maeda, Jian Chen, Mengxue Wang, Keiji Naruse, Ken Takahashi

MethodsX   8   101404 - 101404   2021.5

The Mechanisms of the Development of Atherosclerosis in Prediabetes Reviewed

Yin Liang, Mengxue Wang, Chen Wang, Yun Liu, Keiji Naruse, Ken Takahashi

International Journal of Molecular Sciences   22 ( 8 )   4108 - 4108   2021.4

Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions—Diabetes Mellitus, Cardiovascular Diseases, and Ischemia–Reperfusion Injury Reviewed

Wang M, Liu Y, Liang Y, Naruse K, Takahashi K

Frontiers in Cardiovascular Medicine   8   2021.4

Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia Reviewed

Yun Liu, Mengxue Wang, Yin Liang, Chen Wang, Keiji Naruse, Ken Takahashi

International Journal of Molecular Sciences   22 ( 4 )   1729 - 1729   2021.2

The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors Reviewed

Manh Tien Tran, Yuka Okusha, Yunxia Feng, Masatoshi Morimatsu, Penggong Wei, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Hirohiko Okamura, Keiji Naruse, Takayuki Tsukuba, Kuniaki Okamoto

International Journal of Molecular Sciences   21 ( 24 )   9352 - 9352   2020.12

In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System Reviewed

Kensuke Kataoka, Ryota Kurimoto, Hiroki Tsutsumi, Tomoki Chiba, Tomomi Kato, Kana Shishido, Mariko Kato, Yoshiaki Ito, Yuichiro Cho, Osamu Hoshi, Ayako Mimata, Yuriko Sakamaki, Ryo Nakamichi, Martin K. Lotz, Keiji Naruse, Hiroshi Asahara

Frontiers in Cell and Developmental Biology   8   2020.6

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes Reviewed

Liu Y, Liang Y, Wang M, Wang C, Wei H, Naruse K, Takahashi K

Journal of Visualized Experiments   159 ( 159 )   e61104   2020.5

Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans Reviewed International journal

Naoshi Watanabe, Masatoshi Morimatsu, Ayano Fujita, Mika Teranishi, Surabhi Sudevan, Masaru Watanabe, Hiroaki Iwasa, Yutaka Hata, Hiroyuki Kagi, Masayoshi Nishiyama, Keiji Naruse, Atsushi Higashitani

Biochemical and Biophysical Research Communications   523 ( 4 )   853 - 858   2020.3

Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure. Reviewed International journal

Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka

Nature communications   10 ( 1 )   5754 - 5754   2019.12

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Reviewed International journal

Takashi Ohtsuki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Keiichi Asano, Omer Faruk Hatipoglu, Junko Inagaki, Ken Takahashi, Toshitaka Oohashi, Keiichiro Nishida, Keiji Naruse, Satoshi Hirohata

Experimental cell research   383 ( 2 )   111556 - 111556   2019.10

Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells. Reviewed

Wei H, Wang C, Guo R, Takahashi K, Naruse K

Biochemical and biophysical research communications   520 ( 3 )   600 - 605   2019.10

Spiral Trajectory Modulation of Rheotaxic Motile Human Sperm in Cylindrical Microfluidic Channels of Different Inner Diameters. Reviewed

Nishina S, Matsuura K, Naruse K

Acta medica Okayama   73 ( 3 )   213 - 221   2019.6

L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2. Reviewed International journal

Ken Takahashi, Shogo Hayashi, Mari Miyajima, Marei Omori, Jing Wang, Keiko Kaihara, Masatoshi Morimatsu, Chen Wang, Jian Chen, Gentaro Iribe, Keiji Naruse, Masahiro Sokabe

Cell calcium   79   68 - 74   2019.5

Cyclic stretch enhances reorientation and differentiation of 3-D culture model of human airway smooth muscle. Reviewed

Asano S, Ito S, Morosawa M, Furuya K, Naruse K, Sokabe M, Yamaguchi E, Hasegawa Y

Biochemistry and biophysics reports   16   32 - 38   2018.12

TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons. Reviewed

Katanosaka K, Takatsu S, Mizumura K, Naruse K, Katanosaka Y

Scientific reports   8 ( 1 )   16782 - 16782   2018.11

Stretching of single DNA molecules caused by accelerating flow on a microchip. Reviewed

Hirano K, Iwaki T, Ishido T, Yoshikawa Y, Naruse K, Yoshikawa K

The Journal of chemical physics   149 ( 16 )   165101 - 165101   2018.10

Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes. Reviewed

Matsuda Y, Takahashi K, Kamioka H, Naruse K

Biochemical and biophysical research communications   503 ( 3 )   1798 - 1804   2018.9

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology. Reviewed

Wang C, Naruse K, Takahashi K

Cells   7 ( 6 )   E62 - E62   2018.6

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes Reviewed

Yohei Yamaguchi, Gentaro Iribe, Toshiyuki Kaneko, Ken Takahashi, Takuro Numaga-Tomita, Motohiro Nishida, Lutz Birnbaumer, Keiji Naruse

Journal of Physiological Sciences   68 ( 2 )   153 - 164   2018.3

Effects of Mechanical Stress on Periodontal Ligament Reviewed

Fujita Ayano, Morimatsu Masatoshi, Nishiyama Masayoshi, Takashiba Shogo, Naruse Keiji

BIOPHYSICAL JOURNAL   114 ( 3 )   143A   2018.2

The effects of load on transmural differences in contraction of isolated mouse ventricular cardiomyocytes Reviewed

Anastasia Khokhlova, Gentaro Iribe, Leonid Katsnelson, Keiji Naruse, Olga Solovyova

Journal of Molecular and Cellular Cardiology   114   276 - 287   2018.1

Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes Reviewed

Gentaro Iribe, Keiko Kaihara, Yohei Yamaguchi, Michio Nakaya, Ryuji Inoue, Keiji Naruse

Progress in Biophysics and Molecular Biology   130 ( Pt B )   315 - 322   2017.11

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology Reviewed

Yohei Yamaguchi, Gentaro Iribe, Motohiro Nishida, Keiji Naruse

Progress in Biophysics and Molecular Biology   130 ( Pt B )   264 - 272   2017.11

Effects of simulated ischemia on the transmural differences in the Frank–Starling relationship in isolated mouse ventricular cardiomyocytes Reviewed

Anastasia Khokhlova, Gentaro Iribe, Yohei Yamaguchi, Keiji Naruse, Olga Solovyova

Progress in Biophysics and Molecular Biology   130 ( Pt B )   323 - 332   2017.11

Simultaneous mapping of multiple proteins in heart using matrix-assisted laser desorption/ionization imaging mass spectrometry Reviewed

Takahashi K, Naruse K

European Heart Journal   38 ( Suppl 1 )   ehx501.45   2017.8

Effect of Oxidative Stress on Cardiovascular System in Response to Gravity Reviewed

Ken Takahashi, Hiroki Okumura, Rui Guo, Keiji Naruse

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   18 ( 7 )   2017.7

Imaging of Cell Mechanics under High Gravity by Rotational Microscope

Masatoshi Morimatsu, Ken Takahashi, Ayano Fujita, Keiji Naruse

BIOPHYSICAL JOURNAL   112 ( 3 )   271A - 272A   2017.2

Effects of Bepridil on Stretch-Activated BKca Channels and Stretch-Induced Extrasystoles in Isolated Chick Hearts Reviewed

H. Jin, G. Iribe, K. Naruse

PHYSIOLOGICAL RESEARCH   66 ( 3 )   459 - 465   2017

Dynamic Remodeling of the Heart and Blood Vessels: Implications of Health and Disease Reviewed

Ken Takahashi, Hulin Piao, Keiji Naruse

Mechanobiology: Exploitation for Medical Benefit   175 - 189   2016.11

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling Reviewed

Yoshihiro Ujihara, Keiichiro Iwasaki, Satomi Takatsu, Ken Hashimoto, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka

CARDIOVASCULAR RESEARCH   111 ( 4 )   348 - 361   2016.9

Transplantation of dental pulp stem cells suppressed inflammation in sciatic nerves by promoting macrophage polarization towards anti-inflammation phenotypes and ameliorated diabetic polyneuropathy. Reviewed

Omi M, Hata M, Nakamura N, Miyabe M, Kobayashi Y, Kamiya H, Nakamura J, Ozawa S, Tanaka Y, Takebe J, Matsubara T, Naruse K

Journal of diabetes investigation   7 ( 4 )   485 - 496   2016.7

Innovation of vascular engineering by mechanomedicine Reviewed

Ken Takahashi, Keiji Naruse

Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach   283 - 296   2016.1

[Response to mechanical stimulus and cardiovascular homeostasis.] Reviewed

Takahashi K, Naruse K

Clin Calcium   26 ( 12 )   1671 - 1676   2016

Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane Reviewed

Tokuyama E, Nagai Y, Takahashi K, Naruse K

PLoS One   10 ( 1 )   e0141989 - e0141989   2015.11

Transient Receptor Potential Melastatin-4 Is Involved in Hypoxia-Reoxygenation Injury in the Cardiomyocytes Reviewed

Hulin Piao, Ken Takahashi, Yohei Yamaguchi, Chen Wang, Kexiang Liu, Keiji Naruse

PLOS ONE   10 ( 4 )   e0121703 - e0121703   2015.4

A Simple Method for Decreasing the Liquid Junction Potential in a Flow-through-Type Differential pH Sensor Probe Consisting of pH-FETs by Exerting Spatiotemporal Control of the Liquid Junction Reviewed

Akira Yamada, Satoshi Mohri, Michihiro Nakamura, Keiji Naruse

SENSORS   15 ( 4 )   7898 - 7912   2015.4

Development of a Fluidic Gripper for Isolated Cardiomyocytes Reviewed

Yohei Yamaguchi, Yasuyo Yamaguchi, Shuichi Wakimoto, Gentaro Iribe, Keiji Naruse

Proc. of The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society   110 - 110   2015

Real-Time Imaging of ATP Release Induced by Mechanical Stretch in Human Airway Smooth Muscle Cells Reviewed

Norihiro Takahara, Satoru Ito, Kishio Furuya, Keiji Naruse, Hiromichi Aso, Masashi Kondo, Masahiro Sokabe, Yoshinori Hasegawa

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   51 ( 6 )   772 - 782   2014.12

Ca2+ influx and ATP release mediated by mechanical stretch in human lung fibroblasts Reviewed

Naohiko Murata, Satoru Ito, Kishio Furuya, Norihiro Takahara, Keiji Naruse, Hiromichi Aso, Masashi Kondo, Masahiro Sokabe, Yoshinori Hasegawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   453 ( 1 )   101 - 105   2014.10

The significant role of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger 1 on local Ca<sup>2+</sup> control beneath T-tubule membrane Reviewed

Yoshihiro Ujihara, Keiichiro Iwasaki, Satomi Takatsu, Ken Hashimoto, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka

Transactions of Japanese Society for Medical and Biological Engineering   52   212 - O-213   2014.8

Paper-based diagnostic devices for estimating human sperm motility Reviewed

Koji Matsuura, Wenqian Li, Kuan-Hung Chen, Yuka Asano, Keiji Naruse, Chao-Min Cheng

Transactions of Japanese Society for Medical and Biological Engineering   52   551 - O-552   2014.8

Effects of axial stretch on mitochondrial reactive oxygen species in cardiac myocytes Reviewed

Gentaro Iribe, Keiko Kaihara, Keiji Naruse

Transactions of Japanese Society for Medical and Biological Engineering   52   44   2014.8

Load dependency in force-length relations in isolated single cardiomyocytes Reviewed

Gentaro Iribe, Toshiyuki Kaneko, Yohei Yamaguchi, Keiji Naruse

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY   115 ( 2-3 )   103 - 114   2014.8

Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome Reviewed

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

PLOS ONE   9 ( 7 )   e102796 - e102796   2014.7

The Neutral Self-Assembling Peptide Hydrogel SPG-178 as a Topical Hemostatic Agent Reviewed

Seiji Komatsu, Yusuke Nagai, Keiji Naruse, Yoshihiro Kimata

PLOS ONE   9 ( 7 )   e102778 - e102778   2014.7

Paper-based diagnostic devices for evaluating the quality of human sperm Reviewed

Koji Matsuura, Kuan-Hung Chen, Cheng-Han Tsai, Wenqian Li, Yuka Asano, Keiji Naruse, Chao-Min Cheng

MICROFLUIDICS AND NANOFLUIDICS   16 ( 5 )   857 - 867   2014.5

TRPV2 is critical for the maintenance of cardiac structure and function in mice Reviewed

Yuki Katanosaka, Keiichiro Iwasaki, Yoshihiro Ujihara, Satomi Takatsu, Koki Nishitsuji, Motoi Kanagawa, Atsushi Sudo, Tatsushi Toda, Kimiaki Katanosaka, Satoshi Mohri, Keiji Naruse

NATURE COMMUNICATIONS   5 ( 5 )   3932 - 3932   2014.5

蛍光ライブイメージングを用いた骨組織中における細胞内カルシウムオシレーションの計測

石原 嘉人, 菅原 康代, 上岡 寛, 川邉 紀章, 成瀬 恵治, 山城 隆

日本骨形態計測学会雑誌   24 ( 1 )   15 - 22   2014.3

Oscillatory intracellular Ca²⁺responses in living bone Reviewed

Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Naruse K, Yamashiro T

Journal of Oral Biosciences   56 ( 2 )   49 - 53   2014

Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells. Reviewed International journal

Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, Takuwa Y, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I

Pharmacology Research & Perspectives   2 ( 5 )   e00068 - e00068   2014

Coarse-grained molecular dynamics simulations of biomolecules Reviewed

Ken Takahashi, Takayuki Oda, Keiji Naruse

AIMS Biophysics   1 ( 1 )   1 - 15   2014

Effect of azelnidipine and amlodipine on single cell mechanics in mouse cardiomyocytes Reviewed

Gentaro Iribe, Keiko Kaihara, Hiroshi Ito, Keiji Naruse

EUROPEAN JOURNAL OF PHARMACOLOGY   715 ( 1-3 )   142 - 146   2013.9

Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression Reviewed

Motoi Kanagawa, Chih-Chieh Yu, Chiyomi Ito, So-ichiro Fukada, Masako Hozoji-Inada, Tomoko Chiyo, Atsushi Kuga, Megumi Matsuo, Kanoko Sato, Masahiko Yamaguchi, Takahito Ito, Yoshihisa Ohtsuka, Yuki Katanosaka, Yuko Miyagoe-Suzuki, Keiji Naruse, Kazuhiro Kobayashi, Takashi Okada, Shin'ichi Takeda, Tatsushi Toda

HUMAN MOLECULAR GENETICS   22 ( 15 )   3003 - 3015   2013.8

9-Phenanthrol, a TRPM4 Inhibitor, Protects Isolated Rat Hearts from Ischemia-Reperfusion Injury Reviewed

Jing Wang, Ken Takahashi, Hulin Piao, Peng Qu, Keiji Naruse

PLOS ONE   8 ( 7 )   e70587 - e70587   2013.7

Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis Reviewed

Akihiro C.E. Shibata, Limin H. Chen, Rie Nagai, Fumiyoshi Ishidate, Rahul Chadda, Yoshihiro Miwa, Keiji Naruse, Yuki M. Shirai, Takahiro K. Fujiwara, Akihiro Kusumi

Cytoskeleton   70 ( 3 )   161 - 177   2013.3

Ex vivo real-time observation of Ca2+ signaling in living bone in response to shear stress applied on the bone surface Reviewed

Yoshihito Ishihara, Yasuyo Sugawara, Hiroshi Kamioka, Noriaki Kawanabe, Satoru Hayano, Tarek A. Balam, Keiji Naruse, Takashi Yamashiro

BONE   53 ( 1 )   204 - 215   2013.3

A tilting embryo culture system increases the number of high-grade human blastocysts with high implantation competence Reviewed

Tetsuaki Hara, Koji Matsuura, Takashi Kodama, Keiko Sato, Yuko Kikkawa, Tomomi Muneto, Junko Tanaka, Keiji Naruse

REPRODUCTIVE BIOMEDICINE ONLINE   26 ( 3 )   260 - 268   2013.3

Mechanical Stretch Increases the Proliferation While Inhibiting the Osteogenic Differentiation in Dental Pulp Stem Cells Reviewed

Masaki Hata, Keiko Naruse, Shogo Ozawa, Yasuko Kobayashi, Nobuhisa Nakamura, Norinaga Kojima, Maiko Omi, Yuki Katanosaka, Toru Nishikawa, Keiji Naruse, Yoshinobu Tanaka, Tatsuaki Matsubara

TISSUE ENGINEERING PART A   19 ( 5-6 )   625 - 633   2013.3

Detection of Micrococcus Luteus Biofilm Formation in Microfluidic Environments by pH Measurement Using an Ion-Sensitive Field-Effect Transistor Reviewed

Koji Matsuura, Yuka Asano, Akira Yamada, Keiji Naruse

SENSORS   13 ( 2 )   2484 - 2493   2013.2

Mechanobiology in cardiac physiology and diseases Reviewed

Ken Takahashi, Yoshihide Kakimoto, Kensaku Toda, Keiji Naruse

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   17 ( 2 )   225 - 232   2013.2

Synthesis and slow-release characteristics of a self-assembling peptide gel containing phenylalanine azide. Reviewed

Matsuura K, Kitamatsu M, Nagai Y, Naruse K

Recent Patents on Nanomedicine   3 ( 2 )   140 - 145   2013

Developing a small, inexpensive planar patch-clamp device. Reviewed

Kuniyasu K, Fukasawa T, Takahashi K, Naruse K

Trans JSMBE   51 ( suppl )   R-14   2013

Fabrication of a simple and compact patch clamp system for high-throughput recording. Reviewed

Takahashi K, Fukasawa T, Kuniyasu K, Naruse K

Trans JSMBE   51 ( suppl )   R-149   2013

Stretch-activated BK channel and heart function Reviewed

Ken Takahashi, Keiji Naruse

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY   110 ( 2-3 )   239 - 244   2012.10

Archipelago architecture of the focal adhesion: Membrane molecules freely enter and exit from the focal adhesion zone Reviewed

Akihiro C. E. Shibata, Takahiro K. Fujiwara, Limin Chen, Kenichi G. N. Suzuki, Yoshiro Ishikawa, Yuri L. Nemoto, Yoshihiro Miwa, Ziya Kalay, Rahul Chadda, Keiji Naruse, Akihiro Kusumi

CYTOSKELETON   69 ( 6 )   380 - 392   2012.6

In situ imaging of the autonomous intracellular Ca2+ oscillations of osteoblasts and osteocytes in bone Reviewed

Yoshihito Ishihara, Yasuyo Sugawara, Hiroshi Kamioka, Noriaki Kawanabe, Hiroshi Kurosaka, Keiji Naruse, Takashi Yamashiro

BONE   50 ( 4 )   842 - 852   2012.4

The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel Reviewed

Yusuke Nagai, Hidenori Yokoi, Keiko Kaihara, Keiji Naruse

BIOMATERIALS   33 ( 4 )   1044 - 1051   2012.2

Screening of sperm velocity by fluid mechanical characteristics of a cyclo-olefin polymer microfluidic sperm-sorting device Reviewed

Koji Matsuura, Mami Takenami, Yuka Kuroda, Toru Hyakutake, Shinichiro Yanase, Keiji Naruse

REPRODUCTIVE BIOMEDICINE ONLINE   24 ( 1 )   109 - 115   2012.1

Development of observation system to investigate both intracellular calcium concentration and mechanical stimuli to mammalian embryos Reviewed

Koji Matsuura, Koyo Watanabe, Mieko Kodama, Yuka Kuroda, Keiji Naruse

2011 Int. Symp. on Micro-NanoMechatronics and Human Science, Symp. on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "Hyper Bio Assembler for 3D Cellular System Innovation"   99 - 104   2012

Role of Sarcolemmal BKCa Channels in Stretch-Induced Extrasystoles in Isolated Chick Hearts Reviewed

Gentaro Iribe, Honghua Jin, Keiji Naruse

CIRCULATION JOURNAL   75 ( 11 )   2552 - 2558   2011.11

Microtubule Dynamics Regulate Cyclic Stretch-Induced Cell Alignment in Human Airway Smooth Muscle Cells Reviewed

Masataka Morioka, Harikrishnan Parameswaran, Keiji Naruse, Masashi Kondo, Masahiro Sokabe, Yoshinori Hasegawa, Bela Suki, Satoru Ito

PLOS ONE   6 ( 10 )   e26384   2011.10

Comparison between loose fragment chondrocytes and condyle fibrochondrocytes in cellular proliferation and redifferentiation Reviewed

Naoki Takata, Takayuki Furumatsu, Nobuhiro Abe, Keiji Naruse, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE   16 ( 5 )   589 - 597   2011.9

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells Reviewed

T. Tetsunaga, K. Nishida, T. Furumatsu, K. Naruse, S. Hirohata, A. Yoshida, T. Saito, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE   19 ( 2 )   222 - 232   2011.2

Glucose dependency of the metabolic pathway of HEK 293 cells measured by a flow-through type pH/CO2 sensor system using ISFETs Reviewed

Akira Yamada, Satoshi Mohri, Michihiro Nakamura, Keiji Naruse

IEEJ Transactions on Electronics, Information and Systems   131 ( 9 )   1535 - 1539   2011

Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1 alpha Reviewed

Ryuji Kubota, Yasushi Numaguchi, Masakazu Ishii, Manabu Niwa, Kenji Okumura, Keiji Naruse, Toyoaki Murohara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   402 ( 2 )   396 - 401   2010.11

In-vitro Culture with a Tilting Device in Chemically Defined Media During Meiotic Maturation and Early Development Improves the Quality of Blastocysts Derived from In-vitro Matured and Fertilized Porcine Oocytes Reviewed

Takayuki Koike, Koji Matsuura, Keiji Naruse, Hiroaki Funahashi

JOURNAL OF REPRODUCTION AND DEVELOPMENT   56 ( 5 )   552 - 557   2010.10

Application of a microfluidic sperm sorter to the in-vitro fertilization of porcine oocytes reduced the incidence of polyspermic penetration Reviewed

Hikaru Sano, Koji Matsuura, Keiji Naruse, Hiroaki Funahashi

THERIOGENOLOGY   74 ( 5 )   863 - 870   2010.9

Blastocyst quality scoring based on morphologic grading correlates with cell number Reviewed

Koji Matsuura, Nobuyoshi Hayashi, Chisato Takiue, Rei Hirata, Toshihiro Habara, Keiji Naruse

FERTILITY AND STERILITY   94 ( 3 )   1135 - 1137   2010.8

Actin Cytoskeleton Regulates Stretch-Activated Ca2+Influx in Human Pulmonary Microvascular Endothelial Cells Reviewed

Satoru Ito, Bela Suki, Hiroaki Kume, Yasushi Numaguchi, Masakazu Ishii, Mai Iwaki, Masashi Kondo, Keiji Naruse, Yoshinori Hasegawa, Masahiro Sokabe

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   43 ( 1 )   26 - 34   2010.7

Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes Reviewed

Gentaro Iribe, Honghua Jin, Keiko Kaihara, Keiji Naruse

EXPERIMENTAL PHYSIOLOGY   95 ( 6 )   699 - 711   2010.6

Improved development of mouse and human embryos using a tilting embryo culture system Reviewed

Koji Matsuura, Nobuyoshi Hayashi, Yuka Kuroda, Chisato Takiue, Rei Hirata, Mami Takenami, Yoko Aoi, Nanako Yoshioka, Toshihiro Habara, Tetsunori Mukaida, Keiji Naruse

REPRODUCTIVE BIOMEDICINE ONLINE   20 ( 3 )   358 - 364   2010.3

A fully automated pH measurement system for 96-well microplates using a semiconductor-based pH sensor Reviewed

Akira Yamada, Satoshi Mohri, Michihiro Nakamura, Keiji Naruse

SENSORS AND ACTUATORS B-CHEMICAL   143 ( 2 )   464 - 469   2010.1

Automatic measurement system for biological applications based on pH using ISFET sensor probe Reviewed

Akira Yamada, Satoshi Mohri, Michihiro Nakamura, Keiji Naruse

2010 International Symposium on Micro-NanoMechatronics and Human Science: From Micro and Nano Scale Systems to Robotics and Mechatronics Systems, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010   19 - 24   2010

Application of mechanical stimuli using a microfluidic air actuating system to cultured mammalian embryos Reviewed

Jing-Chun Li, Koji Matsuura, Yuka Kuroda, Hiroaki Funahashi, Keiji Naruse

2010 International Symposium on Micro-NanoMechatronics and Human Science: From Micro and Nano Scale Systems to Robotics and Mechatronics Systems, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010   29 - 34   2010

Optimizing the conditions for pH measurement with an automated pH measurement system using a flow-through-type differential sensor probe consisting of pH-FETs. Reviewed

Yamada A, Mohri S, Nakamura M, Naruse K

Journal of Robotics and Mechatronics   22 ( 2 )   197 - 203   2010

A Rapid Microfluidic Switching System for Analysis at the Single Cellular Level Reviewed

Akira Yamada, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse

IEEE TRANSACTIONS ON NANOBIOSCIENCE   8 ( 4 )   306 - 311   2009.12

Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells Reviewed

Mai Iwaki, Satoru Ito, Masataka Morioka, Susumu Iwata, Yasushi Numaguchi, Masakazu Ishii, Masashi Kondo, Hiroaki Kume, Keiji Naruse, Masahiro Sokabe, Yoshinori Hasegawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   389 ( 3 )   531 - 536   2009.11

Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia Reviewed

Masakazu Ishii, Yasushi Numaguchi, Kenji Okumura, Ryuji Kubota, Xiuyang Ma, Ryuichiro Murakami, Keiji Naruse, Toyoaki Murohara

ATHEROSCLEROSIS   206 ( 1 )   109 - 118   2009.9

Mechanical stretch stimulates integrin alpha V beta 3-mediated collagen expression in human anterior cruciate ligament cells Reviewed

Tomonori Tetsunaga, Takayuki Furumatsu, Nobuhiro Abe, Keiichiro Nishida, Keiji Naruse, Toshifumi Ozaki

JOURNAL OF BIOMECHANICS   42 ( 13 )   2097 - 2103   2009.9

Stress-Axis Regulated Exon (STREX) in the C terminus of BKCa channels is responsible for the stretch sensitivity Reviewed

Keiji Naruse, Qiong-Yao Tang, Masahiro Sokabe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   385 ( 4 )   634 - 639   2009.8

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures Reviewed

Tsutomu Mochizuki, Takaaki Sokabe, Isao Araki, Kayoko Fujishita, Koji Shibasaki, Kunitoshi Uchida, Keiji Naruse, Schuichi Koizumi, Masayuki Takeda, Makoto Tominaga

JOURNAL OF BIOLOGICAL CHEMISTRY   284 ( 32 )   21257 - 21264   2009.8

Application of a numerical simulation to improve the separation efficiency of a sperm sorter Reviewed

Toru Hyakutake, Yuki Hashimoto, Shinichiro Yanase, Koji Matsuura, Keiji Naruse

BIOMEDICAL MICRODEVICES   11 ( 1 )   25 - 33   2009.2

Uniaxial Cyclic Stretch Increases Glucose Uptake into C2C12 Myotubes through a Signaling Pathway Independent of Insulin-like Growth Factor I Reviewed

M. Iwata, S. Suzuki, K. Hayakawa, T. Inoue, K. Naruse

HORMONE AND METABOLIC RESEARCH   41 ( 1 )   16 - 22   2009.1

Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium Reviewed

Chao-Min Cheng, Koji Matsuura, I-Jan Wang, Yuka Kuroda, Philip R. LeDuc, Keiji Naruse

LAB ON A CHIP   9 ( 22 )   3306 - 3309   2009

Impairment of leukocyte deformability in patients undergoing esophagectomy Reviewed

Tomohiko Suemori, Hiroshi Morimatsu, Satoshi Mizobuchi, Kiyoshi Morita, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION   41 ( 2 )   127 - 136   2009

Application of a flow-through type pH/CO2 sensor system based on ISFET for evaluation of the glucose dependency of the metabolic pathways in cultured cells Reviewed

Satoshi Mohri, Akira Yamada, Noriko Goda, Michihiro Nakamura, Keiji Naruse, Fumihiko Kajiya

SENSORS AND ACTUATORS B-CHEMICAL   134 ( 2 )   447 - 450   2008.9

Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the G(q/11) protein Reviewed

F. Yasui, M. Miyazu, A. Yoshida, K. Naruse, A. Takai

BRITISH JOURNAL OF PHARMACOLOGY   154 ( 4 )   890 - 900   2008.6

A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells Reviewed

Satoru Ito, Hiroaki Kume, Keiji Naruse, Masashi Kondo, Naoya Takeda, Susumu Iwata, Yoshinori Hasegawa, Masahiro Sokabe

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   38 ( 4 )   407 - 413   2008.4

Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta Reviewed

Nobutaka Shimizu, Kimiko Yamamoto, Syotaro Obi, Shinichiro Kumagaya, Tomomi Masumura, Yasumasa Shimano, Keiji Naruse, Jun K. Yamashita, Takashi Igarashi, Joji Ando

JOURNAL OF APPLIED PHYSIOLOGY   104 ( 3 )   766 - 772   2008.3

Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel Reviewed

Yuji Hirano, Naoki Ishiguro, Masahiro Sokabe, Masaharu Takigawa, Keiji Naruse

JOURNAL OF BIOTECHNOLOGY   133 ( 2 )   245 - 252   2008.1

Analysis of cyclic-stretching responses using cell-adhesion-patterned cells Reviewed

Yuki Katanosaka, Jin-Hua Bao, Tomoyo Komatsu, Tomohiko Suemori, Akira Yamada, Satoshi Mohri, Keiji Naruse

JOURNAL OF BIOTECHNOLOGY   133 ( 1 )   82 - 89   2008.1

Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats Reviewed

Masahito Kajiya, Masanori Hirota, Yousuke Inai, Takahiko Kiyooka, Taro Morimoto, Tatsuo Iwasaki, Kousuke Endo, Satoshi Mohri, Juichiro Shimizu, Toyotaka Yada, Yasuo Ogasawara, Keiji Naruse, Tohru Ohe, Fumihiko Kajiya

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   292 ( 6 )   H2737 - H2744   2007.6

Automation of pH measurement using a flow-through type differential pH sensor system based on pH-FET Reviewed

Mohri S, Nakamura M, Naruse K

IEEJ Trans SM   127 ( 8 )   367 - 370   2007

Uniaxial cyclic stretch-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in cultured skeletal muscle cells Reviewed

Masahiro Iwata, Kimihide Hayakawa, Taro Murakami, Keiji Naruse, Keisuke Kawakami, Masumi Inoue-Miyazu, Louis Yuge, Shigeyuki Suzuki

PATHOBIOLOGY   74 ( 3 )   159 - 168   2007

Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle Reviewed

Satoru Ito, Hiroaki Kume, Tetsuya Oguma, Yasushi Ito, Masashi Kondo, Kaoru Shimokata, Bela Suki, Keiji Naruse

EUROPEAN JOURNAL OF PHARMACOLOGY   552 ( 1-3 )   135 - 142   2006.12

Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue: roles of mechanical force and the cytoskeleton Reviewed

S Ito, A Majumdar, H Kume, K Shimokata, K Naruse, KR Lutchen, D Stamenovic, B Suki

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY   290 ( 6 )   L1227 - L1237   2006.6

Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs Reviewed

H Takeda, K Komori, N Nishikimi, Y Nimura, M Sokabe, K Naruse

LIFE SCIENCES   79 ( 3 )   233 - 239   2006.6

Spatial and temporal application of microfluidics to cells Reviewed

Akira Yamada, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse

2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE   220 - +   2006

Activation of a mechanosensitive BK channel by membrane stress created with amphipaths Reviewed

Z Qi, SP Chi, XY Su, K Naruse, M Sokabe

MOLECULAR MEMBRANE BIOLOGY   22 ( 6 )   519 - 527   2005.11

Involvement of reactive oxygen species in cyclic stretch-induced NF-kappa B activation in human fibroblast cells Reviewed

H Amma, K Naruse, N Ishiguro, M Sokabe

BRITISH JOURNAL OF PHARMACOLOGY   145 ( 3 )   364 - 373   2005.6

Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch Reviewed

A Sasamoto, M Nagino, S Kobayashi, K Naruse, Y Nimura, M Sokabe

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   288 ( 5 )   C1012 - C1022   2005.5

Fabrication of reconfigurable protein matrices by cracking Reviewed

XY Zhu, KL Mills, PR Peters, JH Bahng, EH Liu, J Shim, K Naruse, ME Csete, MD Thouless, S Takayama

NATURE MATERIALS   4 ( 5 )   403 - 406   2005.5

Stretch-induced cell proliferation is mediated by FAK-MAPK pathway Reviewed

JG Wang, M Miyazu, P Xiang, SN Li, M Sokabe, K Naruse

LIFE SCIENCES   76 ( 24 )   2817 - 2825   2005.4

Reconfigurable protein matrices for prolonged neuroblasts patterning and retraction Reviewed

XY Zhu, KL Mills, PR Peters, K Naruse, ME Csete, MD Thouless, S Takayama

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology   393 - 395   2005

Catheter-based prostacyclin synthase gene transfer prevents in-stent restenosis in rabbit atheromatous arteries Reviewed

Y Numaguchi, K Okumura, M Harada, K Naruse, M Yamada, H Osanai, H Matsui, M Ito, T Murohara

CARDIOVASCULAR RESEARCH   61 ( 1 )   177 - 185   2004.1

Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytes Reviewed

QY Tang, Z Qi, K Naruse, M Sokabe

JOURNAL OF MEMBRANE BIOLOGY   196 ( 3 )   185 - 200   2003.12

Stretch-induced IL-6 secretion from endothelial cells requires NF-kappa B activation Reviewed

S Kobayashi, M Nagino, S Komatsu, K Naruse, Y Nimura, M Nakanishi, M Sokabe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   308 ( 2 )   306 - 312   2003.8

Selective chemical treatment of cellular microdomains using multiple laminar streams Reviewed

S Takayama, E Ostuni, P LeDuc, K Naruse, DE Ingber, GM Whitesides

CHEMISTRY & BIOLOGY   10 ( 2 )   123 - 130   2003.2

The role of calcium in regulating the response of osteoblasts to mechanical stretch Reviewed

Danceu T, Adam R, Naruse K, Freeman M, Hauschka P

FEBS letter   536   193 - 197   2003

Mechanical stress-dependent secretion of interleukin 6 by endothelial cells after portal vein embolization: clinical and experimental studies Reviewed

M Kawai, K Naruse, S Komatsu, S Kobayashi, M Nagino, Y Nimura, M Sokabe

JOURNAL OF HEPATOLOGY   37 ( 2 )   240 - 246   2002.8

Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries Reviewed

M Yamada, Y Numaguchi, K Okumura, M Harada, K Naruse, H Matsui, T Ito, T Hayakawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   22 ( 2 )   256 - 262   2002.2

Uni-axial cyclic stretch induces the activation of transcription factor nuclear factor B in human fibroblast cells Reviewed

H Inoh, N Ishiguro, SI Sawazaki, H Amma, M Miyazu, H Iwata, M Sokabe, K Naruse

FASEB JOURNAL   16 ( 1 )   405 - +   2002.1

Protamine augments stretch induced calcium increase in vascular endothelium Reviewed

K Murase, K Naruse, A Kimura, K Okumura, T Hayakawa, M Sokabe

BRITISH JOURNAL OF PHARMACOLOGY   134 ( 7 )   1403 - 1410   2001.12

Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation Reviewed

JG Wang, M Miyazu, E Matsushita, M Sokabe, K Naruse

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   288 ( 2 )   356 - 361   2001.10

SA channel mediates superoxide production in HUVECs Reviewed

K Aikawa, N Nishikimi, T Sakurai, Y Nimura, M Sokabe, K Naruse

LIFE SCIENCES   69 ( 15 )   1717 - 1724   2001.8

Mechanical behavior in living cells consistent with the tensegrity model Reviewed

N Wang, K Naruse, D Stamenovic, JJ Fredberg, SM Mijailovich, IM Toric-Norrelykke, T Polte, R Mannix, DE Ingber

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   98 ( 14 )   7765 - 7770   2001.7

Laminar flows - Subcellular positioning of small molecules Reviewed

S Takayama, E Ostuni, P LeDuc, K Naruse, DE Ingber, GM Whitesides

NATURE   411 ( 6841 )   1016 - 1016   2001.6

Stretch-induced morphological changes of human endothelial cells depend on the intracellular level of Ca2+ rather than of cAMP Reviewed

T Yamada, K Naruse, M Sokabe

LIFE SCIENCES   67 ( 21 )   2605 - 2613   2000.10

Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes Reviewed

K Naruse, J Nakamura, Y Hamada, M Nakayama, S Chaya, T Komori, K Kato, Y Kasuya, K Miwa, K Naruse, N Hotta

EXPERIMENTAL EYE RESEARCH   71 ( 3 )   309 - 315   2000.9

Erratum: 'Molecular identification of a eukaryotic, stretch-activated nonselective cation channel' (Science (Aug. 6, 1999) (882)) Reviewed

M. Kanzaki, M. Nagasawa, I. Kojima, C. Sato, K. Naruse, M. Sokabe, H. Iida

Science   288 ( 5470 )   1347   2000.5

Molecular identification of a eukaryotic, stretch-activated nonselective cation channel Reviewed

M Kanzaki, M Nagasawa, Kojima, I, C Sato, K Naruse, M Sokabe, H Iida

SCIENCE   285 ( 5429 )   882 - 886   1999.8

An aldose reductase inhibitor prevents the glucose-induced increase in PDGF-beta receptor in cultured rat aortic smooth muscle cells Reviewed

Y Kasuya, J Nakamura, Y Hamada, M Nakayama, H Sasaki, T Komori, S Chaya, G Watanabe, K Naruse, E Nakashima, K Kato, N Hotta

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   261 ( 3 )   853 - 858   1999.8

Characterization of a newly found stretch-activated K-Ca,K-ATP channel in cultured chick ventricular myocytes Reviewed

T Kawakubo, K Naruse, T Matsubara, N Hotta, M Sokabe

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   276 ( 6 )   H1827 - H1838   1999.6

Activation of pp60(src) is critical for stretch-induced orienting response in fibroblasts Reviewed

XR Sai, K Naruse, M Sokabe

JOURNAL OF CELL SCIENCE   112 ( 9 )   1365 - 1373   1999.5

Appropriately spaced nuclear localizing signals are necessary for efficient nuclear import of nonnuclear proteins Reviewed

HJW Borgeld, K Naruse, S Nishikawa, J Zhang, A Kikuchi, K Furukawa, K Yagi, M Tanaka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   256 ( 2 )   278 - 283   1999.3

Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury Reviewed

Y Numaguchi, K Naruse, M Harada, H Osanai, S Mokuno, K Murase, H Matsui, Y Toki, T Ito, K Okumura, T Hayakawa

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   19 ( 3 )   727 - 733   1999.3

Orientation change of cardiocytes induced by cyclic stretch stimulation: Time dependency and involvement of protein kinases Reviewed

K Kada, K Yasui, K Naruse, K Kamiya, Kodama, I, J Toyama

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   31 ( 1 )   247 - 259   1999.1

An aldose redutase inhibitor prevents the intimal thickening in coronary arteries of galactose-fed beagle dogs Reviewed

Y. Kasuya, M. Ito, J. Nakamura, Y. Hamada, M. Nakayama, S. Chaya, T. Komori, K. Naruse, E. Nakashima, K. Kato, N. Koh, N. Hotta

Diabetologia   42 ( 12 )   1404 - 1409   1999

Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation Reviewed

K Naruse, Sai, X, N Yokoyama, M Sokabe

FEBS LETTERS   441 ( 1 )   111 - 115   1998.12

Peroxide production and apoptosis in cultured cells carrying mtDNA mutation causing encephalomyopathy Reviewed

J Zhang, M Yoneda, K Naruse, HJW Borgeld, JS Gong, S Obata, M Tanaka, K Yagi

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL   46 ( 1 )   71 - 79   1998.9

Pp125(FAK) is required for stretch dependent morphological response of endothelial cells Reviewed

K Naruse, T Yamada, XR Sai, M Hamaguchi, M Sokabe

ONCOGENE   17 ( 4 )   455 - 463   1998.7

Involvement of SA channels of cultured endothelial cells Reviewed

Keiji Naruse, Takako Yamada, Masahiro Sokabe

American Journal of Physiology - Heart and Circulatory Physiology   274 ( 5 )   H1532 - H1538   1998.5

Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch Reviewed

K Naruse, T Yamada, M Sokabe

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   274 ( 5 )   H1532 - H1538   1998.5

Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells Reviewed

T Kato, N Ishiguro, H Iwata, T Kojima, T Ito, K Naruse

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   244 ( 3 )   615 - 619   1998.3

Both focal adhesion kinase and c-ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells Reviewed

K Shibata, F Kikkawa, A Nawa, AA Thant, K Naruse, S Mizutani, M Hamaguchi

CANCER RESEARCH   58 ( 5 )   900 - 903   1998.3

Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines Reviewed

K Imaizumi, Y Hasegawa, T Kawabe, N Emi, H Saito, K Naruse, K Shimokata

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   18 ( 2 )   205 - 212   1998.2

Up-regulation of integrin beta(3) expression by cyclic stretch in human umbilical endothelial cells Reviewed

N Suzuki, K Naruse, Y Asano, T Okamoto, N Nishikimi, T Sakurai, Y Nimura, M Sokabe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   239 ( 2 )   372 - 376   1997.10

Mechanotransduction and intracellular signaling mechanisms of stretch-induced remodeling in endothelial cells Reviewed

M Sokabe, K Naruse, S Sai, T Yamada, K Kawakami, M Inoue, K Murase, M Miyazu

HEART AND VESSELS   ( Suppl 12 )   191 - 193   1997

Mechanosensitive ion channels: single channel vs. whole cell activities Reviewed

Sokabe M, Naruse K, Nunogaki K

Prog Cell Res   6   139 - 149   1997

Effects of repetitive stretch stimulation on neonatal rat cardiocytes in vitro Reviewed

Kada K, Yasui K, Naruse K, Toyama J

Environmental Medicine   40 ( 1 )   69 - 72   1996

Inhibitory action of repeated stretch stimulation on apoptosis in neonatal rat cardiocytes Reviewed

Yasui K, Shimano H, Kada K, Naruse K, Toyama J

Environmental Medicine   40 ( 2 )   175 - 177   1996

PLATEAU PATTERN OF AFFERENT DISCHARGE RATE FROM FROG-MUSCLE SPINDLES Reviewed

M SOKABE, K NUNOGAKI, K NARUSE, H SOGA, N FUJITSUKA, A YOSHIMURA, F ITO

JOURNAL OF NEUROPHYSIOLOGY   70 ( 1 )   275 - 283   1993.7

INVOLVEMENT OF STRETCH-ACTIVATED ION CHANNELS IN CA-2+ MOBILIZATION TO MECHANICAL STRETCH IN ENDOTHELIAL-CELLS Reviewed

K NARUSE, M SOKABE

AMERICAN JOURNAL OF PHYSIOLOGY   264 ( 4 )   C1037 - C1044   1993.4

MECHANICS OF PATCH CLAMPED AND INTACT CELL-MEMBRANES IN RELATION TO SA CHANNEL ACTIVATION Reviewed

M SOKABE, K NUNOGAKI, K NARUSE, H SOGA

JAPANESE JOURNAL OF PHYSIOLOGY   43 ( Suppl 1 )   S197 - S204   1993

DIFFERENTIAL RESPONSES OF CA-ACTIVATED K-CHANNELS TO BRADYKININ IN SENSORY NEURONS AND F-11 CELLS Reviewed

K NARUSE, DS MCGEHEE, GS OXFORD

AMERICAN JOURNAL OF PHYSIOLOGY   262 ( 2 )   C453 - C460   1992.2

ELECTROPHYSIOLOGICAL ANALYSIS OF STRUCTURAL ASPECTS OF VOLTAGE-DEPENDENT SR K+ CHANNEL Reviewed

M SOKABE, M KASAI, K NOMURA, K NARUSE

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY   98 ( 1 )   23 - 30   1991

CLASSIFICATION OF THE INTRAFUSAL MUSCLE-FIBERS IN THE FROG-MUSCLE SPINDLE - HISTOCHEMICAL AND IMMUNOFLUORESCENT STUDIES Reviewed

A YOSHIMURA, N FUJITSUKA, M SOKABE, K NARUSE, K NOMURA, FH DIWAN, F ITO

JOURNAL OF ANATOMY   172   89 - 101   1990.10

AMINOGLYCOSIDE BLOCKADE OF CA2+-ACTIVATED K+ CHANNEL FROM RAT-BRAIN SYNAPTOSOMAL MEMBRANES INCORPORATED INTO PLANAR BILAYERS Reviewed

K NOMURA, K NARUSE, K WATANABE, M SOKABE

JOURNAL OF MEMBRANE BIOLOGY   115 ( 3 )   241 - 251   1990.5

Effects of ions and drugs on the responses of sensory axon terminals of decapsulated frog muscle spindles Reviewed

Fumio Ito, Masahiro Sokabe, Kazushi Nomura, Keiji Naruse, Noriaki Fujitsuka, Atsushi Yoshimura

Neuroscience Research Supplements   12 ( C )   S15 - S26   1990

Advanced Elastomers: Technology, properties and applications

（ Role： Joint author ,  Use of silicone elastomer-based microfluidic devices and systems in reproductive technologies.）

InTech  2012.9 

Use of Silicone Elastomer-Based Microfluidic Devices and Systems in Reproductive Technologies

Matsuura K, Naruse K

2012 

第５章アクチュエータが切り拓く医療、福祉--5.1医学、バイオ研究での利用--.

成瀬恵治（ Role： Sole author）

2011.11 

第７章生体組織への近似化、分化制御 3.伸展培養法

片野坂友紀, 竹内 崇, 貝原恵子, 成瀬恵治

(株)羊土社  2008.12 

改訂 培養細胞実験ハンドブック

片野坂友紀、竹内 崇、貝原恵子、*成瀬恵治（第７章生体組織への近似化、分化制御 3.伸展培養法.）

(株)羊土社  2008.12 

第3章 細胞機能解析技術. メカニカルストレスに対する細胞応答の解析技術

片野坂友紀, 竹内 崇, 成瀬恵治

(株)シーエムシー  2008.9 

次世代医療のための高分子材料工学

片野坂友紀、竹内 崇、*成瀬恵治（第3章 細胞機能解析技術. メカニカルストレスに対する細胞応答の解析技術.）

(株)シーエムシー  2008.9 

第５章 心血管系細胞への機械刺激負荷技術

片野坂友紀, 入部玄太郎, 山田 章, 成瀬恵治

(株)シーエムシー  2008.4 

バイオテクノロジーシリーズ 細胞分離・操作技術の最前線

片野坂友紀、入部玄太郎、山田 章、*成瀬恵治（第５章 心血管系細胞への機械刺激負荷技術.）

(株)シーエムシー  2008.4 

ナノテク・バイオMEMS時代の分離・計測技術

*成瀬恵治（細胞研究用および医療診断用チップ.）

(株)シーエムシー出版  2006.6 

「蛋白質 核酸 酵素」増刊号：細胞骨格と接着

*成瀬恵治（ソフトリソグラフィーを駆使したメカノトランスダクションの研究.）

共立出版  2006.6 

細胞研究用および医療診断用チップ

成瀬恵治

(株)シーエムシー  2006.2 

細胞骨格と情報伝達?細胞テンセグリティー・モデルを中心にー

成瀬恵治

(株)エヌ・ティー・エス  2005.6 

Biomechanics at micro- and nanoscale levels

Hiroshi Wada（Effects of mechanical stresses on the migrating behavior of endothelial cells.）

World Scientific  2004.4 

Effects of mechanical stresses on the migrating behavior of endothelial cells

Tanaka T, Naruse K, Sokabe M

World Scientific  2004 

細胞膜の変形と細胞応答−細胞の形が機能を決める？

曾我部正博, 成瀬恵治

共立出版  2000.8 

Cell Shape Control and Mechanical Signalling through the Cytoskeleton

Goldmann, W, Alonso, J, K. Bojanowki, C.. Brangwynne, C. S. Chen, M. E. Chicurel, L. Dike, S. Huang, K. Lee, A. Maniotis, R. Mannix, H. McNamee, C. J. Meyer, Naruse K, K. Parker, G. Plopper, T. Polte, N. Wang, L. Yan, D. E. Ingber

Oxford University Press  1999 

Mechanosensitive ion channels: single channel vs. whole cell responses

Sokabe M, Nunogaki K, Naruse K

Elsevier Science  1997 

細胞膜の機能

成瀬恵治

名古屋大学出版会  1997 

血管活性化ー張力（分担）

成瀬恵治, 曾我部正博

1996 

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.

Naruse K

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   54   83 - 90   2018

特集 新しい医療を拓くメカノバイオロジー--11．メカノ生殖補助医療の展開--

成瀬恵治

医薬ジャーナル   53 ( 6 )   1489 - 1494   2017.6

Application of mechanobiological engineering to regenerative and reproductive medicine Invited

Takahashi K, Oh H, Iribe G, Matsuura K, Naruse K

Trans JSMBE   55 ( 4PM-Abstract )   340 - 340   2017

【メカノバイオサイエンス〜力の科学と医療の最前線〜】 力学刺激に応答する循環器系の恒常性

高橋 賢, 成瀬恵治

Clinical Calcium   26 ( 12 )   1671 - 1676   2016.11

メカノメディスン：メカノ生殖補助医療

成瀬恵治

医学のあゆみ   257 ( 10 )   1058 - 1062   2016.6

メカノメディスン

成瀬恵治

呼吸と循環   64 ( 2 )   177 - 185   2016.2

力学刺激に応答する循環器系の恒常性 Invited

高橋賢, 成瀬恵治

Clinical Calcium   26 ( 12 )   21 - 26   2016

Mechanosensitive ion channels

Ken Takahashi, Yusuke Matsuda, Keiji Naruse

AIMS Biophysics   3 ( 1 )   63 - 74   2016

iPS治療とメカニカルストレス

高橋 賢, 成瀬 恵治

ファルマシア   51 ( 11 )   1038 - 1041   2015.11

メカノメディスン：メカノ医工学を用いた医学研究・次世代医療技術への展開

成瀬恵治

日本機械学会誌   118 ( 1161 )   91 - 93   2015.8

Mechanomedicine : Applications of Mechanobiology to Medical Sciences and Next-generation Medical Technologies

NARUSE Keiji

Journal of the Japan Society of Mechanical Engineers   118 ( 1161 )   533 - 535   2015.8

心臓・血管の組織工学と再生医療.

高橋 賢, 成瀬恵治

人工臓器   43 ( 3 )   206 - 208   2014.12

Disease-Specific Induced Pluripotent Stem Cells Identify the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 During Cardiac Development of Hypoplastic Left Heart Syndrome

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

CIRCULATION   130   2014.11

生殖医療・育種デバイス

松浦宏治, 成瀬恵治

生物工学会誌   92 ( 4 )   30 - 33   2014.3

Involvement of TRPC in the Slow Force Response Observed in Mouse Ventricular Myocytes

Yohei Yamaguchi, Toshiyuki Kaneko, Keiji Naruse, Gentaro Iribe

BIOPHYSICAL JOURNAL   106 ( 2 )   772A - 772A   2014.1

生殖医療・育種デバイス(<特集>マイクロバイオ技術の潮流と展望～動物細胞の培養・計測・評価技術への応用～)

松浦 宏治, 成瀬 恵治

生物工学会誌 : seibutsu-kogaku kaishi   92 ( 4 )   180 - 183   2014

Patient-specific Induced Pluripotent Stem Cells For Modeling Hypoplastic Left Heart Syndrome

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Ken Takahashi, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

CIRCULATION   126 ( 21 )   2012.11

Factors-based Human Cardiomyocytes Differentiation Exhibits Defective Maturation and Excitation Through Aberrant Calcium Handling Proteins

Suguru Tarui, Junko Kobayashi, Masataka Hirata, Ken Takahashi, Gentaro Iribe, Keiji Naruse, Shingo Kasahara, Shunji Sano, Hidemasa Oh

CIRCULATION   126 ( 21 )   2012.11

Investigation of an automated pH measurement system for the development of medicine

YAMADA A., MOHRI S., NAKAMURA M., NARUSE K.

14 ( 3 )   426 - 427   2012.10

Actuators in the Medical Field

NARUSE Keiji

The Machine Design and Tribology Division meeting in JSME   2012 ( 12 )   3 - 5   2012.4

生体ライブイメージングを用いた骨組織中における自律性細胞内カルシウムオシレーションの検討

石原 嘉人, 菅原 康代, 上岡 寛, 川邉 紀章, 黒坂 寛, 成瀬 恵治, 山城 隆

日本矯正歯科学会大会プログラム・抄録集   70回   225 - 225   2011.10

細胞伸展培養

高橋 賢, 成瀬恵治

Surgery Frontier   18 ( 2 )   59 - 63   2011.6

703 Experimental study behaviors of motile sperm in fluid flow

TACHIBANA Towa, TAKI Keishi, OHNISHI Takaya, HYAKUTAKE Toru, YANASE Shinichiro, MATSUURA Koji, NARUSE Keiji

2011 ( 49 )   171 - 172   2011.2

Essential Role For Microtubule Dynamics In Cyclic Stretch-Induced Cell Alignment In Human Airway Smooth Muscle Cells

S. Ito, H. Parameswaran, M. Morioka, K. Naruse, M. Kondo, M. Sokabe, B. Suki, Y. Hasegawa

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   183   2011

Embryo development and the mechanisms behind the improvements in In Vitro dynamic culture systems

Koji Matsuura, Keiji Naruse

Journal of Mammalian Ova Research   28 ( 4 )   174 - 179   2011

Microfluidic sperm sorter内流体中における精子運動の共集点蛍光顕微観察

松浦 宏治, 成瀬 恵治

生体医工学 : 日本エム・イー学会誌 = Transactions of the Japanese Society for Medical and Biological Engineering : BME   48 ( 6 )   625 - 626   2010.12

新しい伸展刺激負荷方法を用いたメカノトランスダクション研究

片野坂友紀, 成瀬恵治

血管医学   11 ( 4 )   301 - 306   2010.12

Musculoskeletal rehabilitation and bone. A novel approach to mechanotransduction using cell-adhesion-patterned cells

Katanosaka Y, Naruse K

Clin Calcium   20 ( 4 )   514 - 519   2010.4

0236 Mechanobiology of Reproductive Cells and Device Applications

Matsuura Koji, Naruse Keiji

2009 ( 22 )   220 - 220   2010.1

0234 Mechanosensor in Cardiovascular System

2009 ( 22 )   218 - 218   2010.1

0820 Cell stimulation and response analysis using microfluidics

YAMADA Akira, KATANOSAKA Yuki, MOHRI Satoshi, NARUSE Keiji

2009 ( 22 )   315 - 315   2010.1

The Generation of a Novel Animal Model of Inducible Hypertrophy: Overexpression of NCX1 in the Murine Heart Using the Doxycycline-Dependent Promoter

Yuki Katanosaka, Keiichiro Iwasaki, Satoshi Mohri, Keiji Naruse

BIOPHYSICAL JOURNAL   98 ( 3 )   551A - 551A   2010.1

Stretch-Sensitivity of Stretch-Activated BKCa Channels in Post-Hatch Chick Ventricular Myocytes

Gentaro Iribe, Keiji Naruse

BIOPHYSICAL JOURNAL   98 ( 3 )   335A - 335A   2010.1

Mechanobiology and Medicine

Naruse K

Nano bio-Interfaces in Relation to Molecular Mobility   79 - 88   2010

動的環境における胚培養成績上昇機構に関する考察

松浦宏治, 黒田ユカ, 舟橋弘晃, 成瀬恵治

日本生殖医学会雑誌   55 ( 3 )   97 - 97   2010

マイクロ空圧駆動型人工卵管で負荷される力学的刺激

李井春, 松浦宏治, 兒玉美恵子, 黒田ユカ, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集   21st   2010

Ischemia-induced Angiogenesis is Impaired in Aminopeptidase-A deficient Mice with Decreased Stability of HIF-1 alpha

Ryuji Kubota, Yasushi Numaguchi, Masakazu Ishii, Keiji Naruse, Kenji Okumura, Toyoaki Murohara

CIRCULATION   120 ( 18 )   S1151 - S1152   2009.11

ROLE OF STRETCH-ACTIVATED BKCA CHANNELS ON STRETCH-INDUCED ARRHYTHMIAS IN ISOLATED CHICK VENTRICLE

G. Iribe, H. Jin, K. Naruse

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   20   S64 - S64   2009.10

Effects of bepridil on stretch-induced arrhythmia in isolated chick ventricles

G. Iribe, H. Jin, K. Naruse

EUROPEAN HEART JOURNAL   30   32 - 32   2009.9

304 A study to improve the separation efficiency of a sperm sorter using a microfluidic system

SHIMAMURA Yutaka, SUZUKI Yusuke, HASHIMOTO Yuki, HYAKUTAKE Toru, YANASE Shinitirou, MATSUURA Kouji, NARUSE Keiji

2008 ( 21 )   99 - 100   2009.1

602 Modeling of motile sperm in microchannel flow

HASHIMOTO Yuki, TACHIBANA Towa, SHIMAMURA Yutaka, SUZUKI Yusuke, HYAKUTAKE Toru, YANASE Shinichiro, MATSUURA Koji, NARUSE Keiji

2008 ( 21 )   235 - 236   2009.1

MOTILITY AND [Ca2+](i) DISTRIBUTION OF SPERMS IN FLOW CONDITION

Koji Matsuura, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES   59   365 - 365   2009

STRETCH-INDUCED UP-REGULATION OF SOC ACTIVITIES IN HUVEC

Yuki Katanosaka, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES   59   500 - 500   2009

MECHANICAL STRETCH STIMULATES GLUCOSE UPTAKE THROUGH A MECHANISM DISTINCT FROM THAT OF INSULIN-LIKE GROWTH FACTOR 1 IN SKELETAL MUSCLE CELLS

Masahiro Iwata, Shigeyuki Suzuki, Kimihide Hayakawa, Takayuki Inoue, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES   59   206 - 206   2009

PDMSの物性を利用した生殖細胞操作デバイスの作製

松浦宏治, 松浦宏治, 黒田ユカ, 黒田ユカ, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集   20th   2009

傾斜培養によるマウス胚の培養成績とそのマイクロ空間制御

黒田ユカ, 黒田ユカ, 松浦宏治, 松浦宏治, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集   20th   2009

E11 Modeling of motile sperm in microchannel flow

2008   183 - 184   2008.10

E02 A study to improve the separation efficiency of a sperm sorter using a microfluidic system

2008   165 - 166   2008.10

Development of in vitro fertilized thawed human embryo by Tilting Embryo Culture System

TAKIUE Chisato, MATSUURA Koji, HIRATA Rei, AOI Yoko, YOSHIOKA Nanako, HABARA Toshihiro, HAYASHI Nobuyoshi, NARUSE Keiji

25 ( 2 )   S60   2008.4

メカニカルストレスに対する細胞応答の解析技術 Invited

片野坂 友紀, 竹内崇, 成瀬恵治

次世代医療のための高分子材料工学   158 - 167   2008

揺動培養によるマウス胚盤胞到達率の上昇

黒田ユカ, 松浦宏治, 片野坂友紀, 毛利聡, 舟橋弘晃, 成瀬恵治

日本生体医工学会大会プログラム・論文集(CD-ROM)   47th   2008

Hydrogen peroxide plays a crucial role in coronary microvascular vasodilation with increased oxidative stress in right ventricles of pulmonary hypertensive rats

Masahito Kajiya, Yousulke Inai, Taro Morimoto, Tatsuo Iwasaki, Kousuke Endo, Satoshi Mohri, Toyotaka Yada, Keiji Naruse, Tohru Ohe, Fumihiko Kajiya

CIRCULATION   116 ( 16 )   228 - 229   2007.10

岡山大学大学院医歯薬学総合研究科生体機能制御科学専攻・機能制御学システム循環生理学教室(研究室・研究施設紹介)

毛利 聡, 片野坂 友紀, 入部 玄太郎, 成瀬 恵治

生体医工学 : 日本エム・イー学会誌   45 ( 3 )   227 - 228   2007.9

FRS-041 Coronary Microvascular Endothelial Dysfunction with Decreased Glycocalyx Thickness and Increased Reactive Oxygen Species in Spontaneously Hypertensive Rats(Vascular Biology in Endothelial Cells (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Hirota Masanori, Inai Yousuke, Kajiya Masahito, Morimoto Taro, Mohri Satoshi, Naruse Keiji, Ohtsuka Aiji, Tsujioka Katsuhiko, Kajiya Fumihiko

Circulation journal : official journal of the Japanese Circulation Society   71   126 - 126   2007.3

The role of TRP channels in mechanotransduction of HUVEC

Yuki Katanosaka, Tomohiko Suemori, Keiji Naruse

BIOPHYSICAL JOURNAL   291A - 291A   2007.1

細胞力覚とロボティクス

成瀬恵治

日本ロボット学会誌   25 ( 2 )   25 - 31   2007

ソフトリソグラフィーを用いた細胞研究・医療用チップの開発

成瀬恵治

表面科学   28 ( 4 )   204 - 210   2007

細胞研究・医療チップ

成瀬恵治

バイオインダストリー   24 ( 2 )   25 - 36   2007

ヒト臍帯血血管内皮細胞（HUVEC）のストレッチ刺激に対する細胞応答

片野坂友紀, 成瀬恵治

医学のあゆみ   223 ( 6 )   469 - 473   2007

Coronary microvascular endothelial dysfunction with decreased glycocalyx thickness and increased reactive oxygen species in spontaneously hypertensive rats possible compensatory role of EDHF

Masanori Hirota, Yousuke Inai, Masahito Kajiya, Taro Morimoto, Kae Hashiba, Satoshi Mohri, Juichiro Shimizu, Aiji Ohtsuka, Katsuhiko Tsujioka, Keiji Naruse, Takeo Tedoriya, Shunji Sano, Fumihiko Kajiya

CIRCULATION   114 ( 18 )   77 - 78   2006.10

Development of a flow-through type pH/CO_2 sensor system based on ISFET for evaluation of cellular function

MOHRI Satoshi, NAKAMURA Michihiro, NARUSE Keiji

IEICE technical report   106 ( 162 )   1 - 4   2006.7

ソフトリソグラフィーを駆使したメカノトランスダクションの研究

成瀬恵治

蛋白質 核酸 酵素   51 ( 6 )   705 - 714   2006

ISFETセンシングシステムによる迅速細胞機能評価法の開発

毛利 聡, 中村通宏, 成瀬恵治

医学のあゆみ   218 ( 2 )   145 - 148   2006

微小流体技術による体外受精

二井信行, 成瀬恵治, Gary D. Smith, 高山秀一

医学のあゆみ   218 ( 2 )   159 - 163   2006

メカノバイオロジー-基礎から臨床まで-

成瀬恵治

岡山医学会雑誌   118   23 - 31   2006

気道平滑筋細胞に対するメカニカルストレッチの影響：ストレッチ活性型Ca2+チャネルの役割

伊藤 理, 久米裕昭, 伊藤 康, 近藤征史, 武田直也, 岩田 晋, 長谷川好規, 下方 薫, 成瀬恵治

呼吸   25 ( 2 )   S18 - S19   2006

Stretch-sensitive mechanism of SAKCA channel

K Naruse, QY Tang, M Sokabe

BIOPHYSICAL JOURNAL   88 ( 1 )   292A - 292A   2005.1

STREX Exon makes Ca2+-activated big K channels mechanosensitive

K Naruse, QY Tang, M Sokabe

BIOPHYSICAL JOURNAL   86 ( 1 )   545A - 545A   2004.1

A new mechanosensitive channel SAKCA and a new MS channel blocker GsTMx-4

Masahiro Sokabe, Keiji Naruse, Qiong-Yao Tang

Folia Pharmacologica Japonica   124 ( 5 )   301 - 310   2004

ソフトリソグラフィーとメカノバイオロジー

成瀬恵治

血管医学   5 ( 4 )   405 - 413   2004

Structure-Function of a cloned Stretch-Activated 13K Channel (SAKCaC) from hearts and hunting its blockers

M Sokabe, K Naruse, QY Tang

JOURNAL OF PHARMACOLOGICAL SCIENCES   94   68P - 68P   2004

Ionic amphipaths affect the gating of a stretch activated BK channel (SAK(Ca)) cloned from chick heart

Z Qi, K Naruse, M Sokabe

BIOPHYSICAL JOURNAL   84 ( 2 )   234A - 234A   2003.2

Stretch-induced morphological response in endothelial cells.

M Sokabe, K Kawakami, K Naruse

JOURNAL OF PHARMACOLOGICAL SCIENCES   91   66P - 66P   2003

内皮細胞の伸展依存性リモデリング ー分子から形へのインターフェースを見るー

曽我部正博, 河上敬介, 早川公英, 成瀬恵治, 辰巳仁史

血管医学   4   237 - 244   2003

Mechanism of hypertrophy in the nonembolized lobe after portal vein embolization.

M Kawai, K Naruse, S Komatsu, M Nagtno, Y Nimura, M Sokabe

HEPATOLOGY   32 ( 4 )   475A - 475A   2000.10

Report clarification

M Kanzaki, M Nagasawa, Kojima, I, C Sato, K Naruse, M Sokabe, H Iida

SCIENCE   288 ( 5470 )   1347 - 1347   2000.5

Stretch-induced intracellular calcium releases in endothelial cells.

K Murase, K Okumura, K Naruse, M Sokabe

BIOPHYSICAL JOURNAL   78 ( 1 )   472A - 472A   2000.1

機械刺激による細胞のリモデリング：SAチャネルと接着斑蛋白質チロシンリン酸化

曽我部正博, 成瀬恵治, 河上敬介, 辰巳仁史

生体の科学   51   549 - 555   2000

内皮細胞における形態知覚と形態形成の分子機構

曾我部正博, 成瀬恵治, 宮津, 井上真澄美

医学のあゆみ   192   1201 - 1205   2000

Stretching Cells : Stretch-Induced Morphological Changes and Its Intracellular Signaling in Human Umbilical Vein Endothelial Cells

NARUSE Keiji

10 ( 1 )   79 - 83   1999.2

真核生物のCa²⁺透過性機械受容チャネル その発見,性質,機能

飯田秀利, 神崎展, 長沢雅裕, 小島至, 佐藤主税, 成瀬恵治, 曽我部正博

日本細胞生物学会大会講演要旨集   52nd   17   1999

細胞を引っ張る

成瀬恵治

日本血栓止血学会誌   10   79 - 83   1999

Prostacyclin synthase gene transfer inhibits neointimal formation after balloon injury with acceleration of re-endothelialization

Y Numaguchi, K Naruse, M Harada, H Osanai, Y Toki, K Okumura, T Ito

CIRCULATION   98 ( 17 )   670 - 670   1998.10

Prolonged reduction of systemic blood pressure by prostacyclin synthase gene transfer in spontaneously hypertensive rats

Y Numaguchi, K Naruse, M Harada, H Osanai, K Murase, Y Toki, K Okumura, T Ito

CIRCULATION   98 ( 17 )   670 - 670   1998.10

Calcium response induced by mechanical stretch in vascular endothelial cells.

Murase K., Naruse K., Sokabe M.

Biophysics   38 ( 2 )   S48   1998.9

Effect of glucose and aldose reductase inhibition on PDGF-induced proliferation of cultured aortic smooth muscle cells

Y Kasuya, J Nakamura, N Koh, Y Hamada, K Naruse, K Kato, N Hotta

DIABETES   47   A366 - A366   1998.5

The mechanism of cell alignment change elicited by cyclic stretch.

K Kada, K Yasui, K Naruse, J Toyama

BIOPHYSICAL JOURNAL   74 ( 2 )   A361 - A361   1998.2

伸展刺激と血管内皮細胞−伸展刺激の方法と細胞応答の解析法−

成瀬恵治, 蔡暁蕊, 山田恭子, 村瀬吉郎

医用電子と生体工学   36   287 - 292   1998

伸展刺激に対する血管内皮細胞の反応とカルシウムイオン

曽我部正博, 成瀬恵治, 河上敬介, 小畑秀一

Clinical Calcium   8   1316 - 1322   1998

心・血管系のメカノトランスダクション

成瀬恵治

現代医学   45   529 - 535   1998

ストレッチ刺激に対する内皮応答

成瀬恵治, 宮津真寿美, 村瀬吉郎, 曽我部正博

血管と内皮   8   271 - 278   1998

Involvement of protein tyrosine kinase src in orienting reaction of fibroblasts in response to uni-axial cyclic stretch

Sai, X, K Naruse, M Sokabe

MOLECULAR BIOLOGY OF THE CELL   8   770 - 770   1997.11

Suppression of PP120FAK inhibits morphological changes of human endothelial cells in response to cyclic stretch.