研究者詳細 - 黒子　洋介

論文 - 黒子　洋介

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明らかなmigrationもなく複合エンドリークを合併し切迫破裂状態となった胸部大動脈瘤の一例

大澤晋, 藤井泰宏, 増田善逸, 黒子洋介, 佐野俊二

脈管学 56 ( Suppl. ) S193 - S193 2016年10月

A staged decompression of right ventricle allows growth of right ventricle and subsequent biventricular repair in patients with pulmonary atresia and intact ventricular septum. 国際誌

Yasuhiro Kotani, Shingo Kasahara, Yasuhiro Fujii, Takahiro Eitoku, Kenji Baba, Shin-Ichi Otsuki, Yosuke Kuroko, Sadahiko Arai, Shunji Sano

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 50 ( 2 ) 298 - 303 2016年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To achieve the growth of right-sided heart structures, our choice of the first palliation for patients with pulmonary atresia and intact ventricular septum (PA-IVS) includes a modified Blalock-Taussig shunt (BTS) with pulmonary valvotomy. We sought to analyse the impact of the first palliation on the growth of right-sided heart structures and factors associated with a choice of definitive surgical procedure. METHODS: Fifty patients with PA-IVS who underwent a staged surgical approach from 1991 to 2012 were retrospectively reviewed. RESULTS: Right ventricular (RV)-coronary artery fistulas were seen in 42% of patients at the time of birth. All 50 patients had a modified BTS with pulmonary valvotomy. Six patients died after the first palliation or inter-stage. Thirty patients achieved a biventricular repair (BVR group), 6 patients had a 1 + 1/2 ventricular repair (1 + 1/2V group) and 5 patients had a Fontan completion (Fontan group). After modified BTS with pulmonary valvotomy, tricuspid valve z-score did not increase in any of the group (BVR: pre -2.79 vs post -2.24, 1 + 1/2V: pre -5.25 vs post -6.69, Fontan: pre -6.82 vs post -7.94). Normalized RV end-diastolic volume increased only in BVR group after modified BTS with pulmonary valvotomy (BVR: pre 32% vs post 64%, 1 + 1/2V: pre 43% vs post 42%, Fontan: pre 29% vs post 32%). Major RV-coronary artery fistula was a strong factor with proceeding single-ventricle palliation [BVR: 4/30 (13%) patients, 1 + 1/2V: 1/6 (17%) and Fontan: 4/5 (80%)]. CONCLUSIONS: Tricuspid valve growth was not obtained by modified BTS with pulmonary valvotomy; therefore, tricuspid valve size at birth appeared to be a predictor for achieving BVR. Proportionate RV growth was seen only in patients who achieved BVR. However, RV growth was not seen in patients having 1 + 1/2 ventricular repair. Major RV-coronary artery fistula was a strong predictor for proceeding single-ventricle palliation.

DOI： 10.1093/ejcts/ezw124

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腸骨動脈・大腿動脈間人工血管バイパス術後10年目に吻合部破綻をきたした一例

小松弘明, 大澤晋, 藤井泰宏, 柚木靖弘, 増田善逸, 黒子洋介, 佐野俊二

日本臨床外科学会雑誌 77 ( 7 ) 1864 - 1864 2016年7月

左側房室弁の外科治療 AVSDに対するmodified single patch repair 査読

笠原真悟, 佐野俊和, 堀尾直裕, 小林純子, 石神修大, 藤井泰宏, 黒子洋介, 小谷恭弘, 新井禎彦, 佐野俊二

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 115 2016年7月

Type2 endoleak発生に対する予測因子の検討術前にエンドリークを予測できるか?

大澤晋, 藤井泰宏, 黒子洋介, 増田善逸, 佐野俊二

日本血管外科学会雑誌 25 ( Suppl. ) 247 - 247 2016年6月

血管術後のHMGB-1の変化の検討動脈硬化病変・アテローム性病変の除去・隔離によるHMGB-1抑制効果

藤井泰宏, 逢坂大樹, 大澤晋, 増田善逸, 黒子洋介, 佐野俊二

日本血管外科学会雑誌 25 ( Suppl. ) 378 - 378 2016年6月

膠原病はタバコ窩内シャント閉塞のリスクファクターである

藤井泰宏, 大澤晋, 奥山倫弘, 増田善逸, 黒子洋介, 竹内英実, 内田治仁, 佐野俊二, 後藤拓弥, 堀尾直裕, 枝木大治, 小松弘明, 木村紘爾

静脈学 27 ( 2 ) 235 - 235 2016年5月

腸骨動脈・大腿動脈間人工血管バイパス術後10年目に吻合部破綻をきたした一例

小松弘明, 大澤晋, 藤井泰宏, 柚木靖弘, 増田善逸, 黒子洋介, 佐野俊二

岡山医学会雑誌 128 ( 1 ) 81 - 81 2016年4月

成人先天性心疾患の外科治療成績と現在の問題点

小谷恭弘, 笠原真悟, 黒子洋介, 藤井泰宏, 小林純子, 大澤晋, 増田善逸, 佐野俊和, 衛藤弘樹, 枝木大治, 木村公爾, 堀尾直裕, 新井禎彦, 佐野俊二

日本外科学会定期学術集会抄録集 116回 OP - 5 2016年4月

HLHSの外科治療合併症回避のための治療戦略左心低形成症候群に対する連続135例のModified Norwood-Sano手術の治療成績

笠原真悟, 枝木大治, 佐野俊和, 木村紘爾, 堀尾直裕, 後藤拓弥, 小林純子, 石神修大, 藤井泰宏, 黒子洋介, 小谷恭弘, 大澤晋, 増田善逸, 新井禎彦, 佐野俊二

日本心臓血管外科学会学術総会抄録集 46回 PD2 - 1 2016年2月

タバコ窩内シャント設置術の開存率とシャント不全のリスクファクターの検討

藤井泰宏, 大澤晋, 小松弘明, 黒子洋介, 増田善逸, 奥山倫弘, 佐野俊二

日本心臓血管外科学会学術総会抄録集 46回 OP16 - 3 2016年2月

成人先天性心疾患心機能低下例の治療成人期Fontan手術およびTCPC conversionにおける低心機能例の検討

小谷恭弘, 笠原真悟, 黒子洋介, 枝木大治, 佐野俊和, 木村紘爾, 堀尾直裕, 小林純子, 藤井泰宏, 大澤晋, 増田善逸, 新井禎彦, 佐野俊二

日本心臓血管外科学会学術総会抄録集 46回 PR26 - 3 2016年2月

Surgical outcome of hypoplastic left heart syndrome with intact atrial septum. 国際誌

Sadahiko Arai, Yasuhiro Fujii, Yasuhiro Kotani, Yosuke Kuroko, Shingo Kasahara, Shunji Sano

Asian cardiovascular & thoracic annals 23 ( 9 ) 1034 - 8 2015年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The surgical outcomes of hypoplastic left heart syndrome with intact atrial septum remains very poor in spite of the introduction of prenatal diagnosis before the Norwood operation. The hybrid operation consisting of bilateral pulmonary artery banding and balloon atrioseptectomy is one of the treatment strategies to potentially improve this patient population, however, the long-term outcomes are unknown. METHODS: Six consecutive patients with hypoplastic left heart syndrome with intact atrial septum, who underwent the hybrid operation between October 2006 and July 2014, were retrospectively reviewed. Hypoplastic left heart syndrome with highly restrictive atrial communication was excluded. RESULTS: Three patients died after the hybrid operation, due to sepsis, cerebral bleeding, and heart failure. Three patients underwent the modified Norwood operation. One of these died due to severe hypoxia while awaiting the bidirectional Glenn operation. The others underwent a bidirectional Glenn operation and subsequent Fontan completion but died due to lung dysfunction and sudden hemoptysis. CONCLUSIONS: The hybrid operation for hypoplastic left heart syndrome with intact atrial septum may have improved the neonatal outcome and Fontan completion rate in this extremely high-risk group of patients, but the long-term outcome remains dismal. Considering the late mortality related to pulmonary complications, aggressive fetal intervention to create a nonrestrictive atrial septal communication to promote normal development of the pulmonary vessels may be the last resort to improve the long-term outcome.

DOI： 10.1177/0218492315606581

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下大静脈フィルター閉塞が誘因となった症候性下肢動静脈瘻の2症例査読

大澤晋, 藤井泰宏, 藤原寛康, 増田善逸, 黒子洋介, 戸田洋伸, 内田治仁, 村上和敏, 江尻健太郎, 高樽由美, 料治三恵, 逢坂大樹, 竹内英実, 武本梨佳, 本田雅子, 三宅麻希, 佐野俊二

脈管学 55 ( Suppl. ) S212 - S212 2015年10月

日本人の体格を考慮した、タバコ窩内シャント設置術適応の検討

藤井泰宏, 大澤晋, 黒子洋介, 増田善逸, 佐野俊二, 内田治仁, 竹内英実, 戸田洋伸, 逢坂大樹, 武本梨佳

脈管学 55 ( Suppl. ) S179 - S179 2015年10月

Left Ventricular Myxoma Occluding the Suprarenal Abdominal Aorta in an Infant. 国際誌

Takuya Kawabata, Shingo Kasahara, Shin-ichi Ohtsuki, Yosuke Kuroko, Yasuhiro Kotani, Yasuhiro Fujii, Ko Yoshizumi, Sadahiko Arai, Shunji Sano

The Annals of thoracic surgery 100 ( 1 ) 309 - 11 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Myxoma is the most common primary cardiac tumor in adults; however, it is extremely rare in infants. Acute occlusion of the abdominal aorta by a cardiac myxoma is also rare. We report the case of an infant with acute occlusion of the suprarenal abdominal aorta by a left ventricular myxoma. The patient underwent successful catheter embolectomy of the abdominal aorta and surgical resection of the cardiac myxoma. This is a very rare case report of the combination of infantile left ventricular myxoma and acute occlusion of the abdominal aorta.

DOI： 10.1016/j.athoracsur.2014.08.066

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Current Management of Severe CHF by Mechanical Support and Cardiac Transplant 左心低形成症候群に対する心筋幹細胞を用いた再生医療

佐野俊二, 樽井俊, 石神修大, 小林純子, 後藤拓弥, 奥山倫弘, 逢坂大樹, 黒子洋介, 馬場健児, 大月審一, 新井禎彦, 笠原真悟, 王英正

日本小児循環器学会雑誌 31 ( Suppl.1 ) s1 - 147 2015年7月

Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial. 国際誌

Shuta Ishigami, Shinichi Ohtsuki, Suguru Tarui, Daiki Ousaka, Takahiro Eitoku, Maiko Kondo, Michihiro Okuyama, Junko Kobayashi, Kenji Baba, Sadahiko Arai, Takuya Kawabata, Ko Yoshizumi, Atsushi Tateishi, Yosuke Kuroko, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh

Circulation research 116 ( 4 ) 653 - 64 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

RATIONALE: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function. OBJECTIVE: The aim of this study was to test whether intracoronary delivery of CDCs is feasible and safe in patients with hypoplastic left heart syndrome. METHODS AND RESULTS: Between January 5, 2011, and January 16, 2012, 14 patients (1.8±1.5 years) were prospectively assigned to receive intracoronary infusion of autologous CDCs 33.4±8.1 days after staged procedures (n=7), followed by 7 controls with standard palliation alone. The primary end point was to assess the safety, and the secondary end point included the preliminary efficacy to verify the right ventricular ejection fraction improvements between baseline and 3 months. Manufacturing and intracoronary delivery of CDCs were feasible, and no serious adverse events were reported within the 18-month follow-up. Patients treated with CDCs showed right ventricular ejection fraction improvement from baseline to 3-month follow-up (46.9%±4.6% to 52.1%±2.4%; P=0.008). Compared with controls at 18 months, cardiac MRI analysis of CDC-treated patients showed a higher right ventricular ejection fraction (31.5%±6.8% versus 40.4%±7.6%; P=0.049), improved somatic growth (P=0.0005), reduced heart failure status (P=0.003), and lower incidence of coil occlusion for collaterals (P=0.007). CONCLUSIONS: Intracoronary infusion of autologous CDCs seems to be feasible and safe in children with hypoplastic left heart syndrome after staged surgery. Large phase 2 trials are warranted to examine the potential effects of cardiac function improvements and the long-term benefits of clinical outcomes. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01273857.

DOI： 10.1161/CIRCRESAHA.116.304671

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先天性心疾患に合併した肺動脈瘤に対し外科治療を施行した成人の3例

樽井俊, 堀尾直裕, 石神修大, 後藤拓弥, 藤井泰宏, 大澤晋, 小谷恭弘, 黒子洋介, 川畑拓也, 吉積功, 増田善逸, 新井禎彦, 赤木禎治, 笠原真悟, 佐野俊二

日本心臓血管外科学会雑誌 44 ( Suppl. ) 361 - 361 2015年1月

Effects of intravenous cariporide on release of norepinephrine and myoglobin during myocardial ischemia/reperfusion in rabbits. 国際誌

Shigeru Sakurai, Yosuke Kuroko, Shuji Shimizu, Toru Kawada, Tsuyoshi Akiyama, Toji Yamazaki, Masaru Sugimachi, Shunji Sano

Life sciences 114 ( 2 ) 102 - 6 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: To examine the effects of cariporide, a Na(+)/H(+) exchanger-1 inhibitor, on cardiac norepinephrine (NE) and myoglobin release during myocardial ischemia/reperfusion by applying a microdialysis technique to the rabbit heart. MAIN METHODS: In anesthetized rabbits, two dialysis probes were implanted into the left ventricular myocardium and were perfused with Ringer's solution. Cariporide (0.3mg/kg) was injected intravenously, followed by occlusion of the left circumflex coronary artery. During 30-min coronary occlusion followed by 30-min reperfusion, four consecutive 15-min dialysate samples (two during ischemia and two during reperfusion) were collected in vehicle and cariporide-treated groups. Dialysate myoglobin and NE concentrations were measured by immunochemistry and high-performance liquid chromatography, respectively. KEY FINDINGS: Dialysate myoglobin and NE concentrations increased significantly during myocardial ischemia/reperfusion in both vehicle and cariporide-treated groups (P<0.01 vs. baseline). In cariporide-treated group, dialysate myoglobin concentrations were significantly lower than those in vehicle group throughout ischemia/reperfusion (P<0.01 at 0-15 min of ischemia, P<0.05 at 15-30 min of ischemia, P<0.01 at 0-15 min of reperfusion, and P<0.01 at 15-30 min of reperfusion). However, dialysate NE concentrations in cariporide-treated group were lower than those in vehicle group only during ischemia (P<0.01 at 0-15 min of ischemia, and P<0.05 at 15-30 min of ischemia). SIGNIFICANCE: When administered before ischemia, cariporide reduces myoglobin release during ischemia/reperfusion and decreases NE release during ischemia.

DOI： 10.1016/j.lfs.2014.08.008

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