研究者詳細 - 黒子　洋介

論文 - 黒子　洋介

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日本において、controlled DCDからの心臓移植は実現可能か? 海外の現状からみた日本における今後の課題

小谷恭弘, 黒子洋介, 廣田真規, 小野稔, 笠原真悟

移植 59 ( 総会臨時 ) 317 - 317 2024年9月

重症成人先天性心疾患に対する移植適応基準の再考海外の報告からみた成人先天性心疾患患者の心移植におけるわが国の問題点

黒子洋介, 岩崎慶一朗, 小林純子, 角南春樹, 杜徳尚, 小谷恭弘, 中村一文, 赤木禎治, 湯浅慎介, 笠原真悟

移植 59 ( 総会臨時 ) 194 - 194 2024年9月

心停止後ドナーからの移植 DCD心臓移植のための心機能評価装置を搭載した体外式搬送システムの開発と多臓器獲得に向けての灌流方法

廣田真規, 井上善紀, 森岡慧, 黒子洋介, 小谷恭弘, 笠原慎吾

移植 59 ( 総会臨時 ) 159 - 159 2024年9月

Effects of dapagliflozin on myoglobin efflux from cardiomyocyte during myocardial ischemia/reperfusion in anesthetized rats 国際誌

Tomohiro Hayashida, Yosuke Kuroko, Shuji Shimizu, Tsuyoshi Akiyama, Takanori Suezawa, Yukio Kioka, Yasuhiro Kotani, Toshiaki Shishido, Shingo Kasahara

Scientific Reports 14 ( 1 ) 16337 - 16337 2024年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

It has been suggested that sodium-glucose cotransporter 2 (SGLT2) inhibitors have cardioprotective effects during myocardial ischemia/reperfusion (I/R) independent of glucose-lowering action. However, the effects of SGLT2 inhibitors on structural damage to cardiomyocytes in the ischemic region during I/R remain unknown. We applied a microdialysis technique to the heart of anesthetized rats and investigated the effects of an SGLT2 inhibitor, dapagliflozin, on myocardial interstitial myoglobin levels in the ischemic region during coronary occlusion followed by reperfusion. Dapagliflozin was administered systemically (40 μg/body iv) or locally via a dialysis probe (100 μM and 1 mM) 30 min before coronary occlusion. In the vehicle group, coronary occlusion increased the dialysate myoglobin concentration in the ischemic region. Reperfusion further increased the dialysate myoglobin concentration. Intravenous administration of dapagliflozin reduced dialysate myoglobin concentration during ischemia and at 0–15 min after reperfusion, but local administration (100 μM and 1 mM) did not. Therefore, acute systemic administration of dapagliflozin prior to ischemia has cardioprotective effects on structural damage during I/R.

DOI： 10.1038/s41598-024-67195-3

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その他リンク： https://www.nature.com/articles/s41598-024-67195-3

Initial trial of three‑lead wearable electrocardiogram monitoring in a full marathon.

Kenta Hirai, Noriko Sakano, Susumu Oozawa, Daiki Ousaka, Yosuke Kuroko, Shingo Kasahara

Journal of cardiology cases 30 ( 1 ) 24 - 28 2024年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

UNLABELLED: Sudden cardiac arrest during exercise can occur without prior warning signs at rest, highlighting the importance of monitoring for its prevention. To detect the signs of ischemic heart disease, including coronary artery anomalies, ST changes must be detected using three‑lead electrocardiograms (ECGs) corresponding to each region of the three coronary artery branches. We conducted ECG monitoring of five runners during a marathon using a wearable three‑lead ECG device (e-skin ECG; Xenoma Inc., Tokyo, Japan). Data without noise or artifacts were successfully collected for one of five runners during the entire marathon. Within the initial hour of the marathon, poor electrode adhesion to the skin hindered the data collection for the remaining four runners, which resulted in significantly decreased acquisition rate compared with the first hour (86.7 ± 13.4 % to 37.3 ± 36.9 %, p = 0.028). Couplets of premature ventricular contractions with clear ECG waveforms in the three leads were detected in one runner during the marathon. Further device improvements are necessary to enable marathon runners to obtain ECGs efficiently without affecting their performance. This study also demonstrated the potential applications of three‑lead wearable ECG monitoring for other short-duration sports and remote home-based cardiac rehabilitation. LEARNING OBJECTIVE: This is an initial trial of a three‑lead wearable electrocardiogram (ECG) monitoring device during a full marathon. ECG data were obtained with low noise and artifacts during the first hour of the marathon; however, the data acquisition rate decreased in the middle and late stages owing to poor electrode adhesion. This study demonstrated the possibility of applying wearable ECG monitoring during short-term exercise and cardiac rehabilitation to detect warning signs and prevent sudden cardiac arrest.

DOI： 10.1016/j.jccase.2024.03.004

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Initial trial of three‑lead wearable electrocardiogram monitoring in a full marathon

Kenta Hirai, Noriko Sakano, Susumu Oozawa, Daiki Ousaka, Yosuke Kuroko, Shingo Kasahara

Journal of Cardiology Cases 30 ( 1 ) 24 - 28 2024年7月

大学病院と市中病院における透析内シャント設置術の患者背景及び実施術式に関する比較と考察

藤井泰宏, 竹内英実, 加藤源太郎, 井上善紀, 倉田裕次, 黒子洋介, 田邊克幸, 岡本修吾, 小松弘明, 枝木大治, 徳田雄平, 大澤晋, 浅川知彦, 山本修三, 田蒔基行, 西岡聡, 田蒔昌憲, 和田淳, 田蒔正治, 笠原真悟

日本透析医学会雑誌 57 ( Suppl.1 ) 441 - 441 2024年5月

Long-term outcome and cardiac function after anatomic repair of congenitally corrected transposition

Fumi Yokohama, Norihisa Toh, Yasuhiro Kotani, Yoichi Takaya, Yosuke Kuroko, Kenji Baba, Teiji Akagi, Shingo Kasahara, Hiroshi Ito

Interdisciplinary CardioVascular and Thoracic Surgery 38 ( 3 ) 2024年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

<p></p> OBJECTIVES

There is limited information on long-term outcomes and trajectories of ventricular and valvular functions in patients with congenitally corrected transposition of the great arteries after anatomic repair according to the operative strategy with a median follow-up period of more than 10 years.

METHODS

Twenty-nine patients who underwent anatomic repair in Okayama University Hospital between January 1994 and December 2020 were reviewed. Outcomes were compared between patients who underwent a double switch operation (DS group) and patients with an atrial switch with a Rastelli operation (Rastelli–Senning/Mustard group).

RESULTS

Fifteen (52%) were in the DS group and 14 (48%) were in the Rastelli–Senning/Mustard group. The median follow-up period after anatomic repair was 12.7 (interquartile range 4.2–18.8) years. There were 3 (10%) early deaths and 3 (10%) late deaths. Survival rates for the entire cohort at 10 and 20 years were 86% and 71%, respectively, and were not different between the 2 groups. Using competing risk analysis, risks of heart failure, cardiac rhythm device implantation and atrial arrhythmia showed no significant differences between the 2 groups, whereas risk of reoperation was higher in the Rastelli–Senning/Mustard group than that in the DS group. Four patients after a DS operation and 1 patient after a Rastelli technique developed more than moderate aortic regurgitation.

CONCLUSIONS

During a median follow-up period of more than 10 years, mortality rate and ventricular and valvular functions after anatomic repair were acceptable, though the incidences of late complications were relatively high, especially in the Rastelli–Senning/Mustard group.

DOI： 10.1093/icvts/ivae033

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その他リンク： https://academic.oup.com/icvts/article-pdf/38/3/ivae033/57105371/ivae033.pdf

成人先天性心疾患領域における三尖弁形成術

徳田雄平, 小谷恭弘, 倉田裕次, 森岡慧, 成宮悠仁, 岸良匡, 鈴木浩之, 枝木大治, 小松弘明, 井上善紀, 小林純子, 藤井泰宏, 川畑拓也, 黒子洋介, 加藤源太郎, 笠原真悟

日本臨床外科学会雑誌 85 ( 3 ) 459 - 459 2024年3月

Y graft術後の人工血管感染に対して両腋窩-両大腿動脈人工血管バイパス施行後に人工血管除去を施行した1例

倉田裕次, 加藤源太郎, 笠原真悟, 小谷恭弘, 黒子洋介, 川畑拓也, 藤井泰宏, 小林純子, 小松弘明, 井上善紀, 枝木大治, 岸良匡, 成宮悠仁, 鈴木浩之, 森岡慧, 徳田雄平

日本臨床外科学会雑誌 85 ( 3 ) 459 - 459 2024年3月

海外の報告からみた心停止ドナーによる心臓移植の現状

黒子洋介, 小谷恭弘, 廣田真規, 笠原真悟, 小野稔

移植 58 ( 4 ) 412 - 412 2024年3月

移行期医療・ACHD診療の実践的方策移行期医療を断念せざるを得ない患者について考える

馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 川本祐也, 原真佑子, 赤木禎治, 西井伸洋, 杜徳尚, 川畑拓也, 黒子洋介, 小谷恭弘, 笠原真悟

日本成人先天性心疾患学会雑誌 13 ( 1 ) 91 - 91 2024年1月

Cone手術時代の成人Ebstein病の管理成人Ebstein病でのCone手術前後における3D心エコーでの三尖弁輪サイズと開口部の評価

杜徳尚, 小谷恭弘, 中島充貴, 高谷陽一, 川畑拓也, 黒子洋介, 馬場健児, 赤木禎治, 笠原真悟, 中村一文

日本成人先天性心疾患学会雑誌 13 ( 1 ) 79 - 79 2024年1月

ヘパリン起因性血小板減少症患者に対する内シャント造設術の経験

藤井泰宏, 廣田真規, 加藤源太郎, 竹内英実, 黒子洋介, 川畑拓也, 小谷恭弘, 小林純子, 内田治仁, 小松弘明, 井上善紀, 枝木大治, 鈴木浩之, 岸良匡, 成宮悠仁, 森岡慧, 三浦望, 杭ノ瀬慶彦, 武田直人, 笠原真悟

脈管学 63 ( Suppl. ) S178 - S178 2023年10月

ヘパリン起因性血小板減少症患者に対する内シャント造設術の経験

脈管学 63 ( Suppl. ) S178 - S178 2023年10月

左心低形成症候群におけるFontan手術未到達例及びFailed Fontanからの考察左心低形成症候群におけるFontan未到達例およびFailed Fontan症例からみた予後因子

小谷恭弘, 小林純子, 杭ノ瀬慶彦, 武田直人, 三浦望, 森岡慧, 成宮悠仁, 鈴木浩之, 岸良匡, 井上善紀, 小松弘明, 枝木大治, 藤井泰宏, 黒子洋介, 川畑拓也, 廣田真規, 加藤源太郎, 笠原真悟

日本胸部外科学会定期学術集会 76回 CPD1 - 3 2023年10月

単心室における共通房室弁に対するAdjustable Annular Bridging Techniqueの短期成績

鈴木浩之, 小谷恭弘, 森岡慧, 成宮悠仁, 岸良匡, 井上善紀, 枝木大治, 小松弘明, 小林純子, 藤井泰宏, 川畑拓也, 廣田真規, 加藤源太郎, 黒子洋介, 笠原真悟

日本胸部外科学会定期学術集会 76回 CP23 - 4 2023年10月

When to intervene the pulmonary artery: Importance of anatomical assessment in the diagnosis of pulmonary artery coarctation. 国際誌

Eiri Kisamori, Yasuhiro Kotani, Hiroyuki Suzuki, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara

The Journal of thoracic and cardiovascular surgery 166 ( 3 ) 926 - 932 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Pulmonary artery coarctation (PACoA) is a major problem that increases the frequency of intervention. However, there is little evidence regarding the prediction of PACoA development. METHODS: A retrospective chart review was performed on 42 patients who underwent modified Blalock-Taussig shunt and preoperative contrast-enhanced computed tomography. An uneven PA branching was defined as an abnormal ductus arteriosus connection to the left PA distal to the PA branching on contrast-enhanced computed tomography. RESULTS: Nineteen (45.2%) of 42 patients were diagnosed with PACoA. The median diameters of the ductus on the aorta and PA sides were 4.1 mm and 3.6 mm in the PACoA group and 3.6 mm and 2.9 mm in the non-PACoA group, respectively (P = .07 and .28, respectively). Tortuous ductus was recognized in 7 (36.8%) patients in the PACoA group and 14 (60.8%) patients in the non-PACoA group (P = .12). PACoA was associated with pulmonary atresia (16 patients [84.2%] in the PACoA group and 12 patients [52.1%] in the non-PACoA group) (P = .02). All 19 patients had uneven PA branching in the PACoA group, whereas 5 of 23 (21.7%) patients had uneven PA branching in the non-PACoA group (P < .001). CONCLUSIONS: Uneven PA branching rather than the ductus arteriosus size was strongly associated with PACoA development; therefore, morphologic assessment by contrast-enhanced computed tomography should be considered in patients with pulmonary atresia.

DOI： 10.1016/j.jtcvs.2023.02.021

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成人先天性心疾患の心不全に対する多剤併用療法の試み

杜徳尚, 中島充貴, 小谷恭弘, 馬場健児, 黒子洋介, 中村一文, 赤木禎治, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [II - 06] 2023年7月

当院における1.5心室修復術後遠隔期成績

井上善紀, 岸良匡, 堀川優衣, 枝木大治, 小松弘明, 辻龍典, 小林純子, 川畑拓也, 黒子洋介, 小谷恭弘, 笠原真悟

日本小児循環器学会総会・学術集会抄録集 59回 [III - 08] 2023年7月

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