研究者詳細 - 窪木　拓男

論文 - 窪木　拓男

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井上栄徳, 窪木拓男, 前川賢治, 土井郁世, 矢谷博文, 宮脇卓也, 佐藤俊樹

日本補綴歯科学会雑誌 46 ( 5 ) 649 - 654 2002年12月

記述言語：日本語出版者・発行元：(公社)日本補綴歯科学会

42歳男.強度のいびきと無呼吸を家族に指摘された.終夜睡眠ポリグラフィーでは無呼吸指数が33.4,無呼吸低呼吸指数が48.5で,重度の睡眠時無呼吸症と診断した.経鼻的持続陽圧呼吸療法は不快感から施行できず,口腔アプライアンス療法として,上顎と下顎に装着した全歯被覆型のアプライアンスを自作のハーベストタイプの金属製連結装置で連結し,下顎を相対的に前方位で保持させるツーピース型を使用した.治療開始時の下顎前方誘導量は,最大前方滑走量の50%程度の前突量,即ち切端咬合位からスタートし,1ヵ月に1度の頻度で連結装置に金属製のスペーサを追加して前方誘導量を増加させた.その結果,7ヵ月後には無呼吸指数4.5,無呼吸低呼吸指数9.7と著しく改善し,徐波睡眠も全睡眠時間の1.5%から17.4%に増加した.最終的な下顎前方誘導量は最大滑走量の70%であった

DOI： 10.2186/jjps.46.649

J-GLOBAL

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実際の患者の問題点に基づく少数歯欠損機能回復法に関するチュートリアル教育の試み

窪木拓男, 園山亘, 荒川光, 鈴木康司, 藤沢拓生, 小島俊司, 笠井昭夫, 上原淳二, 杉山英樹, 前川賢治, 矢谷博文

日本補綴歯科学会雑誌 46 ( 5 ) 812 - 812 2002年12月

CTGF/Hcs24, a hypertrophic chondrocyte specific gene product, stimulates the proliferation and expression of the cartilage phenotype but not hypertrophy or calcification or articular cartilage in culture.

Nishida T, Kubota S, Nakanishi T, Kuboki T, Yosimichi G, Kondo S, Takigawa M

J Cell Physiol 192, 55 - 63 2002年

Correlation of the near-infrared spectroscopy signals with signal intensity in T<inf>2</inf>-weighted magnetic resonance imaging of the human masseter muscle 査読

Takuo Kuboki, Koji Suzuki, Kenji Maekawa, Mami Inoue-Minakuchi, Claver O. Acero, Yoshinobu Yanagi, Toru Wakasa, Kanji Kishi, Hirofumi Yatani, Glenn T. Clark

Archives of Oral Biology 46 721 - 727 2001年7月

The purpose of this study was to compare and contrast blood volume changes transcutaneously measured using near-infrared (NIR) spectroscopy against water signal intensity changes taken from a transverse T2-weighted MR image of the masseter muscle in healthy human subjects before, during and after contraction. Eight healthy non-smoking males with no history of chronic muscle pain or vascular headaches participated (mean age: 23.9 ± 0.6 years). The MRI data were gathered using a turbo spin echo sequence (TR: 2300 ms; TE: 90 ms; FOV: 188 × 300 mm; scanning time: 30 s; slice thickness: 10 mm) and the slice level was set at the mid-point between the origin and insertion of the masseter. Intramuscular haemoglobin (Hb) levels and water content of the right masseter muscle were continuously monitored for 2 min before, 30 s during and 15 min after a maximum voluntary clenching (MVC) task. Both the near-infrared and MRI data were baseline-corrected and normalized and mean levels were established and plotted. Plots of the data showed that both near-infrared-based total Hb and T2-weighted MRI-based signal-intensity levels clearly decreased during contraction and a clear post-contraction rebound response was evident after the contraction. The near-infrared data were found to be highly correlated with MRI-based signal-intensity data (Pearson's r = 0.909, P < 0.0001). In conclusion, these data provide powerful evidence that near-infrared data (total Hb), transcutaneously taken from the masseter muscle in humans, will reflect the intramuscular water signal intensity changes seen using a T2-weighted MRI imaging method. © 2001 Elsevier Science Ltd.

DOI： 10.1016/S0003-9969(01)00030-9

一般歯科医院の受診患者における顎関節症の症状と徴候の変動査読

西村真紀, 景山正登, 松香芳三, 畑中乾志, 吉田栄介, 水口一, 窪木拓男, 矢谷博文

日本顎頭蓋機能学会誌 Vol.14 ( No.1 ) 23 - 31 2001年

記述言語：日本語出版者・発行元：日本口腔リハビリテーション学会

歯科医院での一般歯科治療を終了しメインテナンス期にある122名にアンケート調査と臨床診査を行い標題の変動を検討した.平均8ヵ月という短い調査期間であったが顎関節症の症状・徴候は少なからず変動しており,特に咀嚼筋の圧痛,顎関節雑音,開口障害の変動が大きかった

J-GLOBAL

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Biomechanical calculation of human TM joint loading with jaw opening 査読

T Kuboki, Y Takenami, K Maekawa, M Shinoda, A Yamashita, GT Clark

JOURNAL OF ORAL REHABILITATION 27 ( 11 ) 940 - 951 2000年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

A three-dimensional, static mathematical calculation of the stomatognathic system was done to predict total temporomandibular joint (TMJ) loading at different levels of jaw opening. The model assumed that muscle forces acting on the mandible could be simulated by a combination of contractile components (CCs) and elastic components (ECs) and that static equilibrium existed within the body of the mandible. The model also imposed the constraint that any generated joint reaction force would act on the centre of the condyle. The results of the model demonstrated that under all conditions of opening and for all values of the elastic modulus selected, the forces between the TMJ condyle and the articular eminence were compressive in nature. The compressive force magnitude increased from 2 .7 to 27 .6 N incrementally as the jaw opened from 10 to 40 mm. Overall data in this study indicated that the TMJ tissues undergo low levels of compression at open positions up to 40mm. Finally, the condition of trismus (increased jaw closing activation with opening) was simulated, the Joint reaction force at 20 mm opening increased from 7 .7 to 64 .9 N with only a 20% activation of the dosers.

超音波形成と音波形成の違いによるピンブリッジのピンホール形成精度について

吉本彰夫, 山下敦, 大西栄史, 窪木拓男, 矢谷博文

日本補綴歯科学会雑誌 44 ( 3 ) 457 - 457 2000年6月

Four-year longitudinal course of TMU symptoms in adult population and the estimation of risk factors in relation to the symptoms.(共著)

Journal of Orofacial Pain 14 ( 3 ) 224 - 232 2000年

Haemodynamic responses in chronically painful, human trapezius muscle to cold pressor stimulation.(共著)

Archires of Oral Bilogy 44 ( 10 ) 805 - 812 1999年10月

Direct adenovirus mediated gene delivery to the temporomandibular joint in guinea pigs. (共著)

Archs Oral Biol 44 ( 9 ) 701 - 709 1999年9月

Effect of intravenous infusion of a beta-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor Stimulation. (共著)

Archs Oral Biol 44 ( 6 ) 475 - 483 1999年6月

ピンブリッジ法の予後調査と新しい超音波形成器によるピンホール形成の試み

吉本彰夫, 山下敦, 窪木拓男, 白井知恵子, 今井誠

日本補綴歯科学会雑誌 43 ( 101回特別 ) 193 - 193 1999年5月

周期的な機械的ストレスを培養軟骨細胞に加え続けると,MMP及びIL-1の発現が誘導され,細胞外マトリックスの分解が引き起こされる

Fujisawa Takuo, Hattori Takako, Takahashi Kojiro, Kuboki Takuo, Yamashita Atsushi, Takigawa Masaharu

The Journal of Biochemistry 125 ( 5 ) 966 - 975 1999年5月

記述言語：英語出版者・発行元：(公社)日本生化学会

機械的刺激による軟骨の分解について調べた.Flexercell strain unitを用いて周期的張力(CTF)を培養軟骨細胞に加えたところ,5kPa及び15kPaの高頻度CTFにより,DNA合成,プロテオグリカン合成,コラーゲン合成の低下が見られた.15kPaの高頻度CTFではIL-1,matrix metalloproteinase-2(MMP-2),MMP-9のmRNAの発現と活性型MMP-9の産生が増加した.この時,プロテオグリカンの分解が促進したが,MMPの阻害剤の存在下では分解の促進が抑えられた.張力を小さくすると,軟骨の分解に関わる遺伝子の発現誘導は見られなかった.強度の高頻度CTFはIL-1,MMP-2,MMP-9のmRNAの発現,及び活性型MMP-9の産生を増大させることから,周期的な機械的ストレスが軟骨の分解を引き起こすと考えられる

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Specific antibodies against human cultured chondrosarcoma (HCS-2/8)and osteosarcoma(Saos-2)cells detected in the serum of the TMJ osteoarthritis patients.(共著)

Archs Oral Biol 44 ( 5 ) 403 - 414 1999年5月

Effect of intravenous infusion of an alpha-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor stimulation. (共著)

Archs Oral Biol 44 ( 4 ) 319 - 327 1999年4月

Haemodynamic response to cold pressor stimulation on chronically painful trapezius muscle 査読

C.O.Acero, Jr, T.Kuboki, K.Maekawa, A.Yamashita, G.T.Clark

Arch Oral Biol 1999年

Connective tissue growth factor induces the proliferation, migration and tube formation of vascular endothelial cells in vitro and angiogenesis in vivo. (共著)

J Biochemistry 126 ( 1 ) 137 - 145 1999年

Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1. (共著)

J Biochemistry 125 ( 5 ) 966 - 975 1999年

The effects of sustained incisal clenching on the temporomandibular joint space. (共著)

Dent Maxillofac Radiol 28 ( 4 ) 214 - 218 1999年

Effect of occlusal appliances and clenching on the internally-deranged temporomandibular joint space.(共著)

J Orofac Pain 13 ( 1 ) 38 - 48 1999年

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