Updated on 2025/05/01

写真a

 
SAIGA Kenta
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Lecturer
Position
Special-Appointment Lecturer
External link

Degree

  • 博士(医学) ( 2011.3   岡山大学 )

Research Areas

  • Life Science / Orthopedics

Professional Memberships

  • 日本スポーツ整形外科学会

    2023.6

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Papers

  • A Characteristic Magnetic Resonance Imaging Finding to Identify Morton Neuroma: The Slug Sign Reviewed

    Masahiro Horita, Kenta Saiga, Tomohiro Fujiwara, Eiji Nakata, Toshifumi Ozaki

    Foot & Ankle Orthopaedics   9 ( 3 )   2024.7

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:SAGE Publications  

    Background:

    Morton neuroma is a common cause of forefoot pain and sensory disturbances, but it is difficult to identify on magnetic resonance imaging (MRI). The aim of this study was to verify the usefulness of a characteristic MRI finding (slug sign) for identifying Morton neuroma and to clarify the relationship between excised neuroma characteristics and preoperative MRI findings.

    Methods:

    Twenty-two web spaces were retrospectively assessed from the second and third intermetatarsal spaces of 11 feet of 10 patients (7 women and 3 men, aged average 59.5 years) who underwent surgical excision of Morton neuroma between 2017 and 2022. Asymptomatic web spaces were used as control. Neuromas with 2 branches of the plantar digital nerves on axial T1-weighted MRI (MRI-T1WI) were considered the slug sign. We investigated the preoperative presence of the slug sign in Morton neuroma and asymptomatic control web spaces. We also investigated the relationship between the maximum transverse diameter of the excised specimen and that estimated on coronal MRI-T1WI.

    Results:

    A total of 15 Morton neuromas were excised and assessed. The slug signs were present in 10 intermetatarsal spaces in 15 web spaces with Morton neuroma whereas the sign was found in 1 intermetatarsal space in 7 asymptomatic web spaces. The sensitivity and specificity for the slug sign to diagnose Morton neuroma was 66.7% and 85.7%, respectively. The positive and negative predictive values were 90.9% and 54.5%, respectively. The mean maximum transverse diameter of excised neuromas was 4.7 mm. The mean maximum transverse diameter of neuromas on coronal MRI-T1WI was 3.4 mm. A significant positive correlation was found between the maximum transverse diameters of excised specimens and diameters estimated on coronal MRI-T1WI ( r = 0.799, P < .001).

    Conclusion:

    The slug sign may be a useful indicator of Morton neuroma on MRI to confirm nerve involvement after bifurcation.

    Level of Evidence:

    Level IV, retrospective series.

    DOI: 10.1177/24730114241268285

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    Other Link: https://journals.sagepub.com/doi/full-xml/10.1177/24730114241268285

  • Prosthetic joint infection after total talar replacement: An implant-retained case treated with combined continuous local antibiotic perfusion (CLAP)

    Kohei Iwamoto, Norio Yamamoto, Kenta Saiga, Akihiro Maruo, Tomoyuki Noda, Keisuke Kawasaki, Toshifumi Ozaki

    Journal of Orthopaedic Science   29 ( 1 )   349 - 353   2024.1

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jos.2022.01.002

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  • Comparison of screw versus locking plate fixation via sinus tarsi approach for displaced intra-articular calcaneal fractures. International journal

    Kohei Sato, Masanori Yorimitsu, Takenori Uehara, Shiro Fukuoka, Toshiaki Hata, Kenta Saiga, Tomoyuki Noda, Toshifumi Ozaki

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons   29 ( 1 )   97 - 102   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The optimal treatment of displaced intra-articular calcaneal fractures (DIACF) is controversial. This study compared the fixation stability of screws and locking plates in DIACF treated via the sinus tarsi approach (STA). METHODS: We retrospectively evaluated 118 DIACF cases treated via STA and extracted data that could affect treatment outcomes. Loss of Böhler's angle after surgery was measured to compare fixation stability. RESULTS: The loss of Böhler's angles was significantly smaller in the locking plate group than in the screw group (2.6 ± 2.7º vs. 5.6 ± 5.3º, P < 0.01). There was no difference in the clinical outcomes between the groups. On multivariate logistic regression analysis, screw fixation was significantly associated with loss of Böhler's angle by> 10º (odds ratio, 8.63; 95% confidence interval, 1.16-64.4; P < 0.05). CONCLUSIONS: Locking plate fixation is more reliable than screw fixation for preventing correction loss in DIACF treated via STA. LEVEL OF EVIDENCE: III.

    DOI: 10.1016/j.fas.2022.11.002

    PubMed

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  • Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing. International journal

    Kazuki Hirose, Miho Kuwahara, Eiji Nakata, Tomonori Tetsunaga, Kazuki Yamada, Kenta Saiga, Masaharu Takigawa, Toshifumi Ozaki, Satoshi Kubota, Takako Hattori

    International journal of molecular sciences   23 ( 23 )   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Osteoarthritis (OA) occurs not only in the knee but also in peripheral joints throughout the whole body. Previously, we have shown that the expression of cellular communication network factor 3 (CCN3), a matricellular protein, increases with age in knee articular cartilage, and the misexpression of CCN3 in cartilage induces senescence-associated secretory phenotype (SASP) factors, indicating that CCN3 promotes cartilage senescence. Here, we investigated the correlation between CCN3 expression and OA degenerative changes, principally in human femoral head cartilage. Human femoral heads obtained from patients who received total hip arthroplasty were categorized into OA and femoral neck fracture (normal) groups without significant age differences. Gene expression analysis of RNA obtained from femoral head cartilage revealed that CCN3 and MMP-13 expression in the non-weight-bearing part was significantly higher in the OA group than in the normal group, whereas the weight-bearing OA parts and normal cartilage showed no significant differences in the expression of these genes. The expression of COL10A1, however, was significantly higher in weight-bearing OA parts compared with normal weight-bearing parts, and was also higher in weight-bearing parts compared with non-weight-bearing parts in the OA group. In contrast, OA primary chondrocytes from weight-bearing parts showed higher expression of CCN3, p16, ADAMTS4, and IL-1β than chondrocytes from the corresponding normal group, and higher ADAMTS4 and IL-1β in the non-weight-bearing part compared with the corresponding normal group. Acan expression was significantly lower in the non-weight-bearing group in OA primary chondrocytes than in the corresponding normal chondrocytes. The expression level of CCN3 did not show significant differences between the weight-bearing part and non-weight-bearing part in both OA and normal primary chondrocytes. Immunohistochemical analysis showed accumulated CCN3 and aggrecan neoepitope staining in both the weight-bearing part and non-weight-bearing part in the OA group compared with the normal group. The CCN3 expression level in cartilage had a positive correlation with the Mankin score. X-ray analysis of cartilage-specific CCN3 overexpression mice (Tg) revealed deformation of the femoral and humeral head in the early stage, and immunohistochemical analysis showed accumulated aggrecan neoepitope staining as well as CCN3 staining and the roughening of the joint surface in Tg femoral and humeral heads. Primary chondrocytes from the Tg femoral head showed enhanced expression of Ccn3, Adamts5, p16, Il-6, and Tnfα, and decreased expression of Col2a1 and -an. These findings indicate a correlation between OA degenerative changes and the expression of CCN3, irrespective of age and mechanical loading. Furthermore, the Mankin score indicates that the expression level of Ccn3 correlates with the progression of OA.

    DOI: 10.3390/ijms232315311

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  • Larger sagittal inter-screw distance/tibial width ratio reduces delayed union or non-union after arthroscopic ankle arthrodesis. Reviewed International journal

    Suguru Yokoo, Kenta Saiga, Koji Demiya, Hideki Ohashi, Masahiro Horita, Toshifumi Ozaki

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie   2022.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Arthroscopic ankle arthrodesis (AAA) has risks of complications, such as delayed union and non-union. The number and direction of the inserted screws have been reported as important factors affecting the time to union of AAA. However, the ratio of inter-screw distance (ISD) to tibial width (TW) in different planes has not been investigated. Therefore, we aimed to explore the effect of this ratio on bone union following AAA. METHODS: We retrospectively enrolled 63 patients (64 ankles) undergoing AAA from 2013 to 2019. Then, their age, body mass index (BMI), sex, diabetes mellitus (DM) status, Takakura-Tanaka classification, number of screws and radiographic parameters were analysed. RESULTS: The patients had a mean age of 70.3 (range, 45-91) years. Bone fusion was achieved in 57 ankles (89%) in a mean period of 3.3 (range, 2-6) postoperative months. There were four cases of delayed union and three of non-union. No significant differences in age, BMI, sex, DM, Takakura-Tanaka classification, and number of screws could be detected between the groups. However, the sagittal ISD/TW ratio was significantly larger in the union group than in the delayed/non-union group with a cut-off value of 57.0%. CONCLUSION: Larger sagittal ISD/TW ratios result in reduced post-AAA delayed union or non-union. The surgeon should be aware that the anterior and posterior screw widths should be approximately 60% or more of the anteroposterior width of the tibia.

    DOI: 10.1007/s00590-022-03307-x

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Books

  • 今日の整形外科治療指針 第8版

    雑賀 建多(Sever病, Kohler病, Freiberg病)

    医学書院  2021.10  ( ISBN:9784260042604

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    Total pages:xxvii, 964p   Responsible for pages:839-840   Language:Japanese

    CiNii Books

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  • 整形外科最小侵襲手術ジャーナル No. 100 特集「後足部疾患に対する最小侵襲治療の実際」

    雑賀 建多(踵骨骨折に対する外側小切開内固定術)

    全日本病院出版会  2021.9 

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    Responsible for pages:63-70  

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  • 足関節鏡視下手術の最前線 (整形外科最小侵襲手術ジャーナル No.83)

    雑賀 建多, 大橋 秀基, 堀田 昌宏, 尾﨑 敏文( Role: Contributor ,  鏡視下足関節固定術 - 基本手技と成績 -)

    全日本病院出版会  2017.5  ( ISBN:4881177761

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    Total pages:94   Responsible for pages:51-59   Language:Japanese Book type:Scholarly book

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  • 脳神経外科学(第12版)

    雑賀 建多, 今谷 潤也( Role: Contributor ,  腓骨神経障害)

    金芳堂  2016.3  ( ISBN:9784765316675

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    Responsible for pages:2604-2608   Language:Japanese Book type:Scholarly book

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MISC

  • Treatment for high-energy soil contamination open tibial pilon fracture with Masquelet technique and Ilizarov external fixation: A case report

    近藤宏也, 上原健敬, 根津智史, 松橋美波, 出宮光二, 横尾賢, 斎藤太一, 雑賀建多, 島村安則, 野田知之, 尾崎敏文

    日本創外固定・骨延長学会雑誌   32   226 - 226   2021.4

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    Language:Japanese  

    J-GLOBAL

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  • 満足度を高める外反母趾治療 外反母趾に対する水平骨切り術の患者満足度 術前重症度の影響

    雑賀 建多, 尾崎 敏文

    日本足の外科学会雑誌   41 ( Suppl. )   S109 - S109   2020.10

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    Language:Japanese   Publisher:(一社)日本足の外科学会  

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  • 距踵骨癒合症に対する手術治療成績

    横尾 賢, 雑賀 建多, 野田 知之, 大橋 秀基, 尾崎 敏文

    日本足の外科学会雑誌   41 ( Suppl. )   S204 - S204   2020.10

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    Language:Japanese   Publisher:(一社)日本足の外科学会  

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  • 寛骨臼骨折に対する骨接合術の治療成績

    出宮 光二, 野田 知之, 近藤 宏也, 松橋 美波, 横尾 賢, 上原 健敬, 齊藤 太一, 雑賀 建多, 島村 安則, 尾崎 敏文

    骨折   42 ( Suppl. )   S371 - S371   2020.9

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    Language:Japanese   Publisher:(一社)日本骨折治療学会  

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  • 【整形外科の外傷治療-現状と課題-】外傷教育の現状と課題 岡山大学の取り組み

    野田 知之, 尾崎 敏文, 雑賀 建多, 齋藤 太一, 上原 健敬, 島村 安則

    関節外科   39 ( 4月増刊 )   24 - 29   2020.4

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    Language:Japanese   Publisher:(株)メジカルビュー社  

    <文献概要>・整形外科全体にとって整形外傷教育は非常に重要なテーマであり,骨折・外傷に対する知識や手術手技のアップデートは,専攻医だけではなく指導医を含めた多くの整形外科医に求められるところである。しかし,外傷センターにおいて一貫した治療が展開される欧米と比べて,内因性疾患も含めた救命救急センターの整備・充実に重きを置いたわが国では,このようなシステム構築はなされておらず,未だ模索中といえる。・外傷治療のシステム構築や教育には各地の大学医局にその役割が期待されるところであるが,変性疾患の治療に重きが置かれたり,整形外傷が軽視される傾向は否定できない。外傷教育における施設間差,地域差はいまだ存在する。・若手整形外科医への教育のみならず,中堅医師の技術習得や継続学習,指導医の再学習,さらにはセンター化へ向けてのシステム構築とその普及など,解決すべき問題は多い。

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00282&link_issn=&doc_id=20200414180007&doc_link_id=10.18885%2FJJS.0000000264&url=https%3A%2F%2Fdoi.org%2F10.18885%2FJJS.0000000264&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

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Presentations

  • 距踵骨癒合症に対する手術治療成績

    横尾 賢, 雑賀 建多, 野田 知之, 尾﨑 敏文, 大橋 秀基

    第45回日本足の外科学会学術集会 

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    Event date: 2020.11.26 - 2020.11.27

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 外反母趾に対する水平骨切り術の患者満足度 - 術前重症度の影響 -

    雑賀 建多, 尾﨑 敏文

    第45回日本足の外科学会学術集会 

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    Event date: 2020.11.26 - 2020.11.27

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 診療に役立つ足の整形外科基礎知識 Invited

    雑賀 建多

    第8回整形外科医のためのナレッジセミナー 

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    Event date: 2020.11.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 寛骨臼骨折に対する骨接合術の治療成績

    出宮 光二, 野田 知之, 近藤 宏也, 松橋 美波, 横尾 賢, 上原 健敬, 齋藤 太一, 雑賀 建多, 島村 安則, 尾﨑 敏文

    第46回日本骨折治療学会学術集会 

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    Event date: 2020.9.19 - 2020.9.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 3DCT 計測による大腿骨骨幹部骨折術後の回旋変形の解析

    佐藤 浩平, 野田 知之, 上原 健敬, 島村 安則, 雑賀 建多, 齋藤 太一, 近藤 宏也, 尾﨑 敏文

    第46回日本骨折治療学会学術集会 

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    Event date: 2020.9.19 - 2020.9.21

    Language:Japanese   Presentation type:Oral presentation (general)  

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Research Projects

  • 軟骨再生による変形性足関節症に対する新規治療の開発

    Grant number:24K12374  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    雑賀 建多, 中田 英二, 宝田 剛志, 尾崎 敏文, 高尾 知佳

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • 変形性足関節症におけるCCN3を介した新たな軟骨細胞老化制御機構の解明

    Grant number:21K09280  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    雑賀 建多, 服部 高子, 中田 英二, 二川 摩周, 尾崎 敏文, 久保田 聡

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    変形性足関節症 (osteoarthritis of the ankle; OA of the ankle)の患者では痛みや歩行障害により日常生活動作が著しく低下する。我々はOA関連遺伝子の探索を行い、軟骨組織の発生・分化・再生過程において多様な生理機能を持つCellular Communication Network Factor (CCN)フ ァミリー遺伝子のうち、CCN3がヒトから得られた関節軟骨細胞で加齢とともに有意に増加していることを認めた。また、酸化ストレス刺激により老化を誘導した軟骨細胞でCCN3 発現の上昇を認めた。そこで、これらの結果をもとに足関節においてCCN3が軟骨細胞の老化によるOAを促進するか検討し、足関節の軟骨細胞において、CCN3を介した加齢性変性に対する分子メカニズムを解明することを目的としている。
    <BR>
    研究実施計画に基づき、足関節固定術や人工足関節置換術時に軟骨組織を採取し解析を行なっている。令和3年度は、まず並行して行なっている股関節軟骨研究を進めた。すなわち、Normal群とOA群を荷重部と非荷重部で分け、それぞれの組織をサフラニンOで染色した。肉眼的にOA群荷重部で明らかな軟骨層の菲薄化が確認できた。また、培養した軟骨細胞のmRNAをReal-time PCRを使用しCCN2, 3とADAMTS5で評価した。CCN3, ADAMTS5で荷重、非荷重関係なしにOA群で有意に上昇を認めた。また、両群において年齢との相関はなかった。さらに、組織より直接抽出した軟骨細胞のmRANを評価した。荷重、非荷重に関与することなくそれぞれの因子でOA群において有意に上昇を認めた。また、両群において年齢との相関はなかった。

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Class subject in charge

  • Locomotor System (2024academic year) special  - その他

  • Orthopaedic Surgery (Core Clinical Practice) (2020academic year) special  - その他

  • Locomotor System (2020academic year) special  - その他