2021/12/21 更新

写真a

コヤマ トシヒロ
小山 敏広
KOYAMA Toshihiro
所属
医歯薬学域 准教授
職名
准教授
連絡先
メールアドレス

学位

  • PhD ( 2010年3月 )

研究キーワード

  • 医療ビッグデータ

  • 高齢者医療

  • 感染症

  • 医療政策

  • 臨床疫学

  • 薬剤疫学

  • 医療教育

研究分野

  • ライフサイエンス / 医療管理学、医療系社会学

所属学協会

委員歴

  • 岡山大学   教育改革構想委員会  

    2021年4月 - 2022年3月   

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    団体区分:その他

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論文

  • Impact of the world hand hygiene and global handwashing days on public awareness between 2016 and 2020: Google trends analysis. 査読 国際誌

    Yoshito Nishimura, Hideharu Hagiya, Koichi Keitoku, Toshihiro Koyama, Fumio Otsuka

    American journal of infection control   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Scientific evidence suggest that hand hygiene as one of the most effective measures to control infection. To promote good hand hygiene practices, the World Health Organization introduced May 5 as World Hand Hygiene Day (WHHD), and international stakeholders established Global Handwashing Day (GHD) on October 15. However, its contributions to raising public awareness of hand hygiene is unclear. METHODS: This study evaluates the impact of the WHHD and GHD on the public awareness of hand hygiene in Japan, the United Kingdom, the United States, and worldwide from 2016 to 2020, using the relative search volume of "Hand hygiene" in Google Trends as a surrogate. To identify a statistically significant timepoint of a trend change, we performed Joinpoint regression analysis. RESULTS: Upticks of the relative search volumes as well as joinpoints were noted worldwide around the WHHD and GHD from 2016 to 2019, but no joinpoints were identified around the WHHD and GHD in 2020. No such changes were observed in Japan, the United Kingdom, and the United States during these periods. CONCLUSIONS: While the WHHD was originally established to raise awareness of hand hygiene in healthcare facilities, our result suggests that the WHHD and GHD may not have effectively disseminated the importance of hand hygiene to the general public at a country level. Additional policy measures to advocate hand hygiene to the public are necessary to communicate its benefits.

    DOI: 10.1016/j.ajic.2021.08.033

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  • Impact of the World Antimicrobial Awareness Week on public interest between 2015 and 2020: A Google Trends analysis. 査読 国際誌

    Koichi Keitoku, Yoshito Nishimura, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   111   12 - 20   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: To evaluate the impact of the World Antimicrobial Awareness Week (WAAW) on public awareness of antimicrobial resistance using Google Trends analysis. METHODS: The impact of WAAW on public awareness of 'antimicrobial resistance' (AMR), 'antibacterial', and 'antibiotics' in Japan, the UK, the United States, and worldwide from 2015 to 2020 was analyzed, using the relative search volume (RSV) of Google Trends as a surrogate. A joinpoint regression analysis was performed to identify a statistically significant time point of a change in trend. RESULTS: No joinpoints around WAAW were identified in Japan, the United Kingdom, or the United States from 2015 to 2020 with RSVs of 'AMR', whereas increasing RSVs were noted worldwide in 2017 and 2020. Further, there were decreasing RSVs of 'antibiotics' in the first half of 2020, which could be due to the COVID-19 pandemic. The study results suggest that WAAW did little to improve public awareness of AMR in the selected countries despite its contribution worldwide. CONCLUSIONS: This study implies that we need to develop a more effective method to improve public awareness to fight against AMR.

    DOI: 10.1016/j.ijid.2021.08.018

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  • Relevance of CYP3A5 expression on the clinical outcome of patients with renal cell carcinoma. 査読

    Jun Matsumoto, Yumi Kotera, Shogo Watari, Koichi Takeuchi, Hideo Ueki, Toshihiro Koyama, Koichiro Wada, Masachika Fujiyoshi, Yasutomo Nasu, Noritaka Ariyoshi

    Anticancer Research   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Trends in hepatitis C virus-associated mortality rates in Japan, 1998–2017 査読 国際誌

    Hideharu Hagiya, Toshihiro Koyama, Matsuo Deguchi, Yusuke Minato, Satomi Miura, Tomoko Funahashi, Yusuke Teratani, Yoshito Zamami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu Kano

    Journal of Gastroenterology and Hepatology   2021年5月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    in press

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  • Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan 査読 国際誌

    Tomoko Funahashi, Toshihiro Koyama, Hideharu Hagiya, Ko Harada, Syunya Iinuma, Soichiro Ushio, Yoshito Zamami, Takahiro Niimura, Kazuaki Shinomiya, Keisuke Ishizawa, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

    Drug Safety   2021年4月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    in press

    DOI: 10.1007/s40264-020-01037-9

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  • Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017. 国際誌

    Shinnosuke Fukushima, Hideharu Hagiya, Yuki Otsuka, Toshihiro Koyama, Fumio Otsuka

    Scientific reports   11 ( 1 )   7246 - 7246   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999-2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men's age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: - 8.1, - 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999-2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.

    DOI: 10.1038/s41598-021-86431-8

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  • Trends in the nontuberculous mycobacterial disease mortality rate in Japan: A nationwide observational study, 1997-2016. 査読 国際誌

    Ko Harada, Hideharu Hagiya, Tomoko Funahashi, Toshihiro Koyama, Mitsunobu R Kano, Fumio Otsuka

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan. METHODS: This study used vital statistics data and data on all NTM-associated deaths (N=18,814) among individuals aged ≥40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpoint regression to analyze trends and estimate the average annual percentage change (AAPC). We compared crude NTM- and tuberculosis (TB)-associated mortality rates by sex. RESULTS: The overall crude annual mortality rate increased from 0.63/100,000/year in 1997 to 1.93/100,000/year in 2016 and was the highest among individuals aged 80-84 years. The AAPC of the crude mortality rates among males of all ages and females aged 40-59 years were stable but increased among females aged 60-79 years (3.5%, 95% confidence interval [CI]: 2.8-4.3%) and ≥80 years (4.3%, 95% CI: 3.7-4.9%). Among males, the age-adjusted mortality rates did not show a significant trend, while among females, the rates increased over the study period (AAPC: 4.6%, 95% CI: 2.7-6.6%). In females, the crude NTM-associated mortality rate exceeded the TB mortality rate in 2014, 2015, and 2016. CONCLUSIONS:  NTM mortality increased in Japan between 1997 and 2016, especially among the elderly female population. Given the increasing NTM-associated mortality and susceptible aging population, public health authorities in Japan should pay greater attention to NTM infections.

    DOI: 10.1093/cid/ciaa810

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  • Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013-2015): A retrospective Observational Study. 査読 国際誌

    Toshihiro Koyama, Hideharu Hagiya, Yusuke Teratani, Yasuhisa Tatebe, Ayako Ohshima, Mayu Adachi, Tomoko Funahashi, Yoshito Zamami, Hiroyoshi Y Tanaka, Ken Tasaka, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R Kano

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2020年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    OBJECTIVES: Appropriate antibiotic prescriptions for outpatients with acute respiratory tract infections (ARTIs) are urgently needed in Japan. However, the empirical proof of this need is under-documented. Therefore, we aimed to determine antibiotic prescription rates, and the proportions of antibiotic classes prescribed for Japanese patients with ARTIs. METHODS: We analysed health insurance claims data over 2013-2015 among Japanese patients aged <75 years and determined the following indicators: 1) visit rates for patients with ARTIs and antibiotic prescription rates per 1000 person-years, and 2) proportion of visits by antibiotic-prescribed patients with ARTIs. We defined broad-spectrum antibiotics using the WHO Anatomical Therapeutic Chemical classification 4 level codes. RESULTS: Among 8.65 million visits due to ARTIs at 6859 hospitals and 62,024 physicians' offices, the visit rate and antibiotic prescription rate per 1000 person-years were 990.6 (99% confidence interval [CI], 989.4-991.7) and 532.4 (99% CI, 531.6-533.3), respectively. The visit rates for patients aged 0-17, 18-59, and 60-74 years were 2410.0 (99% CI, 2407.2-2412.9), 683.6 (99% CI, 682.7-684.6), and 682.1 (99% CI, 678.2-686.0), and antibiotic prescription rates were 1093.3 (99% CI, 1091.4-1095.2), 434.1 (99% CI, 433.4-434.9), and 353.4 (99% CI, 350.7-356.1), respectively. The overall proportion of antibiotic prescriptions for ARTI visits was 52.7% and 91.3% of the antibiotics prescribed were broad-spectrum. CONCLUSIONS: Both the visit rates and antibiotic prescription rates for ARTIs were high in this Japanese cohort. The proportion of antibiotic prescriptions exceeded that recommended in the clinical guidelines. Thus, there might be a scope for reducing the current antibiotic prescription rate in Japan.

    DOI: 10.1016/j.jiac.2020.02.001

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  • 日本における副作用に起因した死亡率の傾向に関する全国規模の観察研究

    船橋 智子, 小山 敏広, 萩谷 英大, 原田 洸, 寺谷 祐亮, 座間味 義人, 建部 泰尚, 三上 奈緒子, 大島 礼子, 四宮 一昭, 北村 佳久, 千堂 年昭, 樋之津 史郎, 狩野 光伸

    日本薬学会年会要旨集   140年会   28X - am11   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • Trends in place of death in a super-aged society: A population-based study, 1998–2017. 査読

    Toshihiro Koyama, Hideharu Hagiya, Tomoko Funahashi, Yoshito Zamami, Miyu Yamagishi, Hiroshi Onoue, Yusuke Teratani, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R Kano

    Journal of Palliative Medicine   2020年1月

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    担当区分:筆頭著者, 責任著者  

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  • A nationwide trend analysis in the incidence and mortality of Creutzfeldt–Jakob disease in Japan between 2005 and 2014 査読

    Nishimura, Y., Harada, K., Koyama, T., Hagiya, H., Otsuka, F.

    Scientific Reports   10 ( 1 )   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-72519-0

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  • Place of death trends among patients with dementia in Japan: a population-based observational study. 査読 国際誌

    Toshihiro Koyama, Misato Sasaki, Hideharu Hagiya, Yoshito Zamami, Tomoko Funahashi, Ayako Ohshima, Yasuhisa Tatebe, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R Kano

    Scientific reports   9 ( 1 )   20235 - 20235   2019年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Dementia is a major public health concern in ageing societies. Although the population of Japan is among the most aged worldwide, long-term trends in the place of death (PoD) among patients with dementia is unknown. In this Japanese nationwide observational study, we analysed trends in PoD using the data of patients with dementia who were aged ≥65 years and died during 1999-2016. Trends in the crude death rates and PoD frequencies were analysed using the Joinpoint regression model. Changes in these trends were assessed using the Joinpoint regression analysis in which significant change points, the annual percentage change (APC) and average APCs (AAPC) in hospitals, homes, or nursing homes were estimated. During 1999-2016, the number of deaths among patients with dementia increased from 3,235 to 23,757 (total: 182,000). A trend analysis revealed increased mortality rates, with an AAPC of 8.2% among men and 9.3% among women. Most patients with dementia died in the hospital, although the prevalence of hospital deaths decreased (AAPC: -1.0%). Moreover, the prevalence of nursing home deaths increased (AAPC: 5.6%), whereas the prevalence of home deaths decreased (AAPC: -5.8%). These findings support a reconsideration of the end-of-life care provided to patients with dementia.

    DOI: 10.1038/s41598-019-56388-w

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  • Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study。 査読 国際誌

    BMJ Open   9 ( 12 )   e033462   2019年12月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/bmjopen-2019-033462

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Oral Anticoagulants usage in Japanese Patients aged 18 – 74 years with Non-Valvular Atrial Fibrillation: a retrospective analysis based on insurance claims data 査読 国際誌

    Family Practice   36 ( 6 )   685 - 692   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/fampra/cmz016

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  • Factors Associated With Immune Checkpoint Inhibitor–Related Myocarditis 査読 国際誌

    JAMA Oncology   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1001/jamaoncol.2019.3113

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: A retrospective observational study 査読

    Yusuke Teratani, Hideharu Hagiya, Toshihiro Koyama, Mayu Adachi, Ayako Ohshima, Yoshito Zamami, Hiroyoshi Y. Tanaka, Yasuhisa Tatebe, Ken Tasaka, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Mitsunobu R. Kano, Shiro Hinotsu, Toshiaki Sendo

    Family Practice   36 ( 4 )   402 - 409   2019年8月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    © 2018 The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Background: In this age of antimicrobial resistance, unnecessary use of antibiotics to treat non-bacterial acute respiratory tract infections (ARTIs) and inappropriate use of antibiotics in treating bacterial ARTIs are public health concerns. Purpose: Our aim is to identify the pattern of oral antibiotic prescriptions for outpatients with ARTIs in Japan. Methods: We analysed health insurance claims data of patients (aged ≤74 years) from 2013 to 2015, to determine the pattern of antibiotic prescriptions for outpatient ARTIs and calculated the proportion of each antibiotic. Results: Data on 4.6 million antibiotic prescriptions among 1559394 outpatients with ARTIs were analysed. The most commonly prescribed classes of antibiotics included cephalosporins (41.9%), macrolides (32.8%) and fluoroquinolones (14.7%). The proportion of first-, second- and third-generation cephalosporins was 1.0%, 1.7% and 97.3%, respectively. Fluoroquinolones accounted for a quarter of the prescriptions for ARTIs in patients aged >20 years. In contrast, penicillins accounted for just 8.0% of the total number of antibiotic prescriptions for ARTIs. Conclusions: According to clinical guidelines, penicillins are first-line antibiotics against ARTIs. However, third-generation cephalosporins, macrolides and fluoroquinolones are more frequently prescribed in Japan. Although we could not assess the extent to which appropriate antibiotics are selected, our results support the necessity of improving antibiotic choices in the treatment of ARTIs.

    DOI: 10.1093/fampra/cmy094

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Hypoglycemia associated with pivalate-conjugated antibiotics in young children: A retrospective study using a medical and pharmacy claims database in Japan (in press) 査読 国際誌

    Journal of Infection and Chemotherapy   26 ( 1 )   86 - 91   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jiac.2019.07.013

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Association between rapid antigen detection tests and antibiotics for acute pharyngitis in Japan: A retrospective observational study. 査読 国際誌

    Yusuke Teratani, Hideharu Hagiya, Toshihiro Koyama, Ayako Ohshima, Yoshito Zamami, Yasuhisa Tatebe, Ken Tasaka, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R Kano

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   25 ( 4 )   267 - 272   2019年4月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The application and clinical impact of rapid antigen detection test (RADT) in the treatment of acute pharyngitis is unknown in Japan. We aimed to examine the proportions of RADT usage to identify Group A β-hemolytic Streptococcus (GAS) in outpatients with acute pharyngitis and evaluate the association between RADT and antibiotic treatment. We analyzed health insurance claims data from 2013 to 2015. Logistic regression models were used to analyze associated factors with RADT, overall antibiotic prescription, or penicillin use. We analyzed 1.27 million outpatient visits with acute pharyngitis, in which antibiotics were prescribed in 59.3% of visits. Of the total visits, 5.6% of patients received RADT, and 10.8% of the antibiotics were penicillin. Penicillin selection rates were higher in cases with RADT (25.4%) than those without RADT (9.7%). Compared to large-scale facilities, antibiotic prescription rates were higher in physicians' offices. For factor analysis, age (3-15 years), diagnosis code (streptococcal pharyngitis), size of the medical facility (large-scale hospitals), and physician's specialty (pediatrics) were associated with RADT use. Penicillin selection rate increased with RADT implementation (25.4% vs. 9.7%: adjusted odds ratio 1.55; 95% CI, 1.50-1.60). At 63% of the facilities, the RADT implementation rate was <5% of acute pharyngitis visits prescribed antibiotics. In conclusion, the proportion of RADT usage for outpatients with acute pharyngitis was low in Japan. With appropriate indication and evaluation, we expect that more utilization of RADT can help promote antimicrobial stewardship for outpatients with acute pharyngitis by prompting penicillin therapy. Further investigation with detailed clinical data are warranted.

    DOI: 10.1016/j.jiac.2018.12.005

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database. 査読 国際誌

    Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, Mitsunobu R Kano, Keisuke Ishizawa

    Frontiers in pharmacology   10   1257 - 1257   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using "TargetMine," a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the "survival discharge." Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.

    DOI: 10.3389/fphar.2019.01257

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  • Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. 査読

    PHARMAZIE   73 ( 12 )   740 - 743   2018年12月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1691/ph.2018.8711

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  • Trends in Polypharmacy in Japan: A Nationwide Retrospective Study. 査読 国際誌

    Onoue H, Koyama T, Zamami Y, Hagiya H, Tatebe Y, Mikami N, Shinomiya K, Kitamura Y, Hinotsu S, Sendo T, Ouchi Y, Kano MR

    Journal of the American Geriatrics Society   66 ( 12 )   2267 - 2273   2018年12月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgs.15569

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  • Antibiotic-associated adverse drug events at a Japanese academic hospital. 査読 国際誌

    Journal of Infection and Chemotherapy   25 ( 5 )   392 - 395   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jiac.2018.11.002

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Trends in incidence and mortality of tuberculosis in Japan: A population-based study, 1997–2016 査読

    Epidemiology and Infection   2018年9月

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    担当区分:責任著者  

    DOI: 10.1017/S095026881800290X

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Trends in the medication reviews of community pharmacies in Japan: a nationwide retrospective study. 査読 国際誌

    Toshihiro Koyama, Hiroshi Onoue, Ayako Ohshima, Yuri Tanaka, Yasuhisa Tatebe, Yoshito Zamami, Kazuaki Shinomiya, Yoshihisa Kitamura

    International journal of clinical pharmacy   40 ( 1 )   101 - 108   2018年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    Background The trends in medication reviews made by community pharmacies in Japan are currently unknown. Objective We aimed to comprehensively describe the national trends in medication reviews in Japan's community pharmacies in the backdrop of the country's ageing population. Setting Community pharmacies in Japan. Methods We analysed national health insurance claims data for 2010-2015. These data were provided by the Ministry of Health, Labour and Welfare as part of the Survey of Medical Care Activities in Public Health Insurance. Main outcome measures The national trends in community pharmacy visits involving medicine dispensing and medication reviews that involve consultations with a physician. Results Among the 365 million pharmacy visits for 2010-2015, we identified 373,429 medication reviews accompanied by consultations with a physician. The pharmacy visit rate per 1000 population increased from 427.2 in 2010 to 483.7 in 2015. Medication reviews also increased from 407 per million pharmacy visits in 2010 to 1445 in 2015. Among the 373,429 medication reviews during the study period, the prescription was changed through collaboration with a physician 338,982 times (90.4%). The proportion of medication review acceptance increased from 80.6% in 2010 to 94.8% in 2015. The prescription change rate was higher among older patients than among younger ones. Conclusions Medication reviews by community pharmacists involving consultations with a physician increased in Japan from 2010 to 2015, as did prescription changes following these reviews.

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  • Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit. 査読 国際誌

    Takahiro Niimura, Yoshito Zamami, Toru Imai, Kanako Nagao, Masafumi Kayano, Hidenori Sagara, Mitsuhiro Goda, Naoto Okada, Masayuki Chuma, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Tadashi Koga, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques   21 ( 1 )   54 - 59   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Although the 2016 Japanese guidelines for the management of sepsis recommend de-escalation of treatment after identification of the causative pathogen, adherence to this practice remain unknown. The objective of this study was to evaluate the benefits of de-escalating treatment for sepsis patients at an advanced critical care and emergency medical centre. METHODS: Based on electronic patient information, 85 patients who were transported to the centre by ambulance, and diagnosed with sepsis between January 2008 and September 2013 were enrolled and evaluated. Patients were divided into two groups with and without de-escalation, and comparisons were conducted for several variables, including length of hospital stay, and length of antibiotic administration. Two types of subgroup analysis were conducted between patients with septic shock or positive blood cultures. Statistical analysis was conducted using chi-square and Mann-Whitney U tests. RESULTS: The length of hospital stay after diagnosis was significantly shorter for the de-escalation group than for the non-de-escalation group. In the subgroup analysis, de-escalation for blood culture-positive patients was beneficial in terms of the length of hospital stay and length of antibiotic administration. CONCLUSIONS: The findings of this study suggest that sepsis treatment de-escalation is beneficial for treatment efficacy and appropriate use of antibiotics. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

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  • Administration of Kampo medicine through a tube at an advanced critical care center. 査読

    Takahiro Niimura, Yoshito Zamami, Toru Imai, Tsuyoshi Ito, Hidenori Sagara, Hichiya Hiroyuki, Satoru Esumi, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Manabu Amano, Naomi Kurata, Yoshihisa Kitamura, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa

    The journal of medical investigation : JMI   65 ( 1.2 )   32 - 36   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    n emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration. When the crushing method was employed, poorly water-soluble solid products were formed, while a uniformly dispersed suspension was obtained using the simple suspension method. In addition, the passage rate of amlodipine through the tube was 64% and 93% in the crushing and simple suspension methods, respectively, thereby indicating that the simple suspension method provided more favorable than the crushing method. The results of this study suggested that the passage rate of amlodipine for patients who received Kampo products concurrently was higher when the simple suspension method was used, and an appropriate drug amount might well be able to administered to patients using this method. J. Med. Invest. 65:32-36, February, 2018.

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  • Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest. 査読 国際誌

    Takahiro Niimura, Yoshito Zamami, Toshihiro Koyama, Yuki Izawa-Ishizawa, Masashi Miyake, Tadashi Koga, Keisaku Harada, Ayako Ohshima, Toru Imai, Yutaka Kondo, Masaki Imanishi, Kenshi Takechi, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya, Toshiaki Tamaki, Shiro Hinotsu, Mitsunobu R Kano, Keisuke Ishizawa

    Scientific reports   7 ( 1 )   17919 - 17919   2017年12月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60-10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.

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    その他リンク: http://orcid.org/0000-0002-7755-1754

  • Patterns of CT use in Japan, 2014: A nationwide cross-sectional study 査読

    Toshihiro Koyama, Yoshito Zamami, Ayako Ohshima, Yusuke Teratani, Kazuaki Shinomiya, Yoshihisa Kitamura

    EUROPEAN JOURNAL OF RADIOLOGY   97   96 - 100   2017年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objectives: To describe CT usage in Japan by age, gender, and region and to clarify the relationship between aging and CT examination rate.
    Materials and methods: We conducted a cross-sectional study using openly accessible data from the National Database, which includes all Japanese health insurance claim data from 2014. These data are anonymized and publicly available as spreadsheets. Therefore, this study did not require institutional review board approval. We calculated the rate of CT examinations per 1000 population by age, sex, and region with 99% confidence intervals. Pearson correlation coefficients were calculated between CT rate and aging in each region.
    Results: We analyzed 28.1 million CT scans, and the rate per 1000 population was 221.5 (99% CI, 221.4-221.6). By age, the corresponding rate for age 0-9 years was 28.9, that for age 10-9 years was 48.6, that for 20-29 years was 52.2, that for 30-39 years was 69.0, that for 40-49 years was 105.9, that for 50-59 years was 177.6, that for 60-69 years was 303.3, that for 70-79 years was 532.5 and that for= 80 years was 801.5. The rate for male individuals was 233.6 and that for females was 210.0. The CT examination rate was 171.7 and 296.0 in the lowest-and highest-frequency regions, respectively. The average correlation coefficient between the aging rate in each region and the CT examination rate was 0.58 (0.35-0.74, p = 0.00002).
    Conclusion: In Japan, the CT examination rate per 1000 population was high (third highest in the world). Age may be a factor that increases CT use. Furthermore, because variation in CT examination rates by age, gender, and region were observed, it is necessary to standardize CT utilization.

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  • Drug Repositioning Research Utilizing a Large-scale Medical Claims Database to Improve Survival Rates after Cardiopulmonary Arrest 査読

    Yoshito Zamami, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Keisuke Ishizawa

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   137 ( 12 )   1439 - 1442   2017年12月

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    記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Approximately 100000 people suffer cardiopulmonary arrest in Japan every year, and the aging of society means that this number is expected to increase. Worldwide, approximately 100 million develop cardiac arrest annually, making it an international issue. Although survival has improved thanks to advances in cardiopulmonary resuscitation, there is a high rate of postresuscitation encephalopathy after the return of spontaneous circulation, and the proportion of patients who can return to normal life is extremely low. Treatment for postresuscitation encephalopathy is long term, and if sequelae persist then nursing care is required, causing immeasurable economic burdens as a result of ballooning medical costs. As at present there is no drug treatment to improve postresuscitation encephalopathy as a complication of cardiopulmonary arrest, the development of novel drug treatments is desirable. In recent years, new efficacy for existing drugs used in the clinical setting has been discovered, and drug repositioning has been proposed as a strategy for developing those drugs as therapeutic agents for different diseases. This review describes a large-scale database study carried out following a discovery strategy for drug repositioning with the objective of improving survival rates after cardiopulmonary arrest and discusses future repositioning prospects.

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  • Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia 査読

    Shiho Sato, Yoshito Zamami, Toru Imai, Satoshi Tanaka, Toshihiro Koyama, Takahiro Niimura, Masayuki Chuma, Tadashi Koga, Kenshi Takechi, Yasuko Kurata, Yutaka Kondo, Yuki Izawa-Ishizawa, Toshiaki Sendo, Hironori Nakura, Keisuke Ishizawa

    SCIENTIFIC REPORTS   7 ( 1 )   12683   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Amiodarone (AMD) and nifekalant (NIF) are used in the treatment of ventricular fibrillation or tachycardia; however, only few studies have been conducted on their efficacies. Therefore, a meta-analysis was conducted. Relevant sources were identified from PubMed, Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi. The outcomes were short-term and long-term survival in patients with shock-resistant ventricular fibrillation/pulseless ventricular tachycardia. Thirty-three studies were analysed. The results showed that, compared to the control treatment, AMD did not improve short-term survival (odds ratio (OR): 1.25, 95% confidence interval (CI): 0.91-1.71) or long-term survival (OR: 1.00, 95% CI: 0.63-1.57). However, compared to the control treatment, NIF significantly improved short-term survival (OR: 3.23, 95% CI: 2.21-4.72) and long-term survival (OR: 1.88, 95% CI: 1.36-2.59). No significant difference was observed in short-term survival (OR: 0.85, 95% CI: 0.63-1.15) or long-term survival (OR: 1.25, 95% CI: 0.67-2.31) between AMD- and NIF-treated patients. The results suggest that NIF is beneficial for short-term and long-term survival in shock-resistant ventricular fibrillation/pulseless ventricular tachycardia; however, the efficacy of AMD in either outcome is not clear.

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  • Emotional Intelligence and its Effect on Pharmacists and Pharmacy Students with Autistic-like Traits 査読

    Yuji Higuchi, Masatoshi Inagaki, Toshihiro Koyama, Yoshihisa Kitamura, Toshiaki Sendo, Maiko Fujimori, Hitomi Kataoka, Chinatsu Hayashibara, Yosuke Uchitomi, Norihito Yamada

    AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION   81 ( 4 )   74   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC COLL PHARMACY  

    Objective. To measure whether Emotional intelligence (EI) would minimize the negative association between autistic-like traits (ALT) and empathic behavior and enhance the positive association between ALT and psychological distress.Methods. Our sample population included 823 hospital pharmacists belonging to a district society, and 378 pharmacy students. Analyses were performed to examine relationships between scores on the Emotional Intelligence Scale (EQS), Autism-Spectrum Quotient (AQ), Jefferson Scale of Empathy (JSE), and General Health Questionnaire-12 (GHQ).Results. Complete answers were obtained from 373 pharmacists, and 341 students. EQS partially intervened the associations between AQ and JSE and between AQ and GHQ.Conclusion. EI partially intervened the relationships between ALT and empathy, and between ALT and mental health, both of which are necessary for optimal pharmaceutical practice.

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  • Possibility of Pharmacist in Emergency Medical Care: To Bring Up a Familiar Pharmacist for Emergency Care by Fusing Clinical Pharmacist Activity and University Education Foreword 査読

    Yoshito Zamami, Toshihiro Koyama, Hironori Nakura, Shuichi Enomoto

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   136 ( 7 )   965 - 965   2016年7月

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    記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    DOI: 10.1248/yakushi.15-00286-F

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  • A cross-sectional study of psychological distress, burnout, and the associated risk factors in hospital pharmacists in Japan 査読

    Yuji Higuchi, Masatoshi Inagaki, Toshihiro Koyama, Yoshihisa Kitamura, Toshiaki Sendo, Maiko Fujimori, Yosuke Uchitomi, Norihito Yamada

    BMC PUBLIC HEALTH   16   534   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background: Opportunities for face-to-face communication with patients is increasing in modern hospital pharmacist practice. This may impose new burdens on hospital pharmacists. We performed a cross-sectional study to examine the prevalence of psychological distress, burnout, and compassion fatigue among hospital pharmacists. We also investigated possible relevant factors, such as sex, years of experience, hospital size, interpersonal work hours, and personality traits related to communication.Methods: We mailed self-administered questionnaires to all pharmacists (n = 823) belonging to the prefectural society of hospital pharmacists in Japan. The questionnaires were the General Health Questionnaire (GHQ-12), Burnout (BO) and Compassion Fatigue and Secondary Traumatic Stress (CF/STS) subscales of the Professional Quality of Life Scale, the Autism Spectrum Quotient (AQ), and the Adult ADHD (attention deficit hyperactivity disorder) Self-Report Scale (ASRS). We examined associations between personality traits (AQ, ASRS) and psychological burden (GHQ-12, BO, CF/STS) using rank ANCOVA or multivariate logistic regression analyses.Results: Complete responses were obtained from 380 pharmacists (46.2 % response rate). A substantial number of participants obtained scores that were higher than the cutoff points of the GHQ-12 (54.7 %), BO (49.2 %), and CF/STS (29.2 %). The GHQ-12 scores were negatively affected by years of experience (p < 0.001), and positively affected by AQ (p < 0.001) and ASRS (p < 0.001) scores. The BO scores was positively affected by AQ (p < 0.001) and ASRS (p = 0.001) scores, while the CF/STS (p = 0.023) score was negatively affected by years of experience, and positively affected by AQ (p < 0.001) and ASRS (p < 0.001) scores.Conclusions: There is a high prevalence of psychological distress and work-related burnout/CF among hospital pharmacists. Additionally, two common personality traits, such as autistic-like traits and ADHD-like symptoms, which might be related to communication style, could increase the risk of psychological distress and burnout/CF. Early risk assessment and preventive interventions that are specialized for these characteristics could protect individuals with these specific traits from burnout.

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  • Pharmaceutical Education Focused on Pharmacotherapy in Emergency Medical Care 査読

    Yoshito Zamami, Toshihiro Koyama, Toru Imai, Akane Takemoto, Hidenori Sagara, Toshiaki Sendo, Hironori Nakura

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   136 ( 7 )   987 - 991   2016年7月

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    記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Pharmacists are expected to be active members of the healthcare team in emergency medicine, because many pharmaceuticals are administered to patients with life-threatening conditions. However, adequate education for pharmacists and pharmacy students is not provided. The "Emergency Pharmaceutical Sciences" course was introduced for the first time in Japan by the Department of Pharmacy, Okayama University, to offer advanced education in emergency medicine and research related to critical care. We offer an emergency pharmaceutical training program with high-performance simulators and have succeeded in improving the clinical skills and confidence of pharmacy students. In this review, we introduce our activities intended to mold pharmacy students into emergency pharmacists who can contribute to emergency medicine.

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  • Vascular responses to compound 48/80 in rat mesenteric vascular beds 査読

    Honghua Jin, Zhen Li, Shingo Takatori, Toshihiro Koyama, Xin Jin, Yoshito Zamami, Hiromu Kawasaki, Pengyuan Sun

    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY   94 ( 6 )   620 - 626   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS  

    A further investigation was performed on the vascular effect of endogenous histamine using the histamine releaser, compound 48/80, in rat mesenteric vascular beds with active tone. In preparations with intact endothelium, low concentrations of compound 48/80 (1.53 x 10(-5)-3 x 1.53 x 10(-5) mg/mL) perfusion for 1 min only induced a small vasodilation. High concentrations of compound 48/80 (1.53 x 10(-4)-3 x 1.53 x 10(-2) mg/mL) induced a biphasic vascular responses, an initial vasoconstriction followed a subsequent long-lasting vasodilation. The vasodilation induced by low concentrations of compound 48/80 and the vasoconstriction induced by high concentration of compound 48/80 was inhibited by olopatadine. However, cimetidine did not affect the responses induced by compound 48/80. Endothelium removal enlarged the compound 48/80-induced phase-2 vasoconstriction, while it attenuated the phase-3 vasodilation. Additionally, indomethacin and seratrodast significantly inhibited vasoconstriction but it did not affect the long-lasting vasodilation induced by high concentrations of compound 48/80. Ruthenium red inhibited the vasodilation induced by low concentrations and high concentrations of compound 48/80. These results suggest that the vasoconstriction induce by high concentrations of compound 48/80 is mediated by endogenous histamine released from mast cells. It is also suggested that thromboxane A(2) released from mast cells is related to the vasoconstriction.

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  • Risk factor of acute renal failure induced by edaravone in patients with cerebrovascular disorder 査読

    座間味 義人, 相良 英憲, 萱野 由佳, 小山 敏広, 白石 奈緒子, 江角 悟, 川 豊世武, 千堂 年昭, 氏家 良人, 名倉 弘哲

    日本臨床救急医学会雑誌   Vol.19 ( No.3 )   461 - 465   2016年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    エダラボンを用いた治療は患者の神経学的予後を改善する一方,急性腎障害発現のリスクがあると報告されている.本研究はエダラボン投与による急性腎障害発現を予防するために,エダラボン投与時の患者背景から危険因子を解析することを目的とした.岡山大学病院においてエダラボンが投与された患者を対象に,患者基本情報およびエダラボン投与情報,血液検査結果を電子カルテより遡及的に調査した.調査データから単変量解析を実施し,抽出した因子を用いて二項ロジスティック回帰分析を行った結果,感染症の併発が,エダラボンによる急性腎障害発現の有意な危険因子(予測因子)であることが示唆された.したがって,感染症の所見がある患者にエダラボンを投与する際は,急性腎障害発現に留意する必要がある.

    DOI: 10.11240/jsem.19.461

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  • Evaluation of pharmaceutical lifesaving skills training oriented pharmaceutical intervention. 査読 国際誌

    Zamami Y, Imai T, Imanishi M, Takechi K, Shiraishi N, Koyama T, Sagara H, Shiino Y, Sendo T, Ishizawa K

    Journal of pharmaceutical health care and sciences   2 ( 1 )   21 - 21   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s40780-016-0054-7

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  • Exploring autistic-like traits relating to empathic attitude and psychological distress in hospital pharmacists 査読

    Yuji Higuchi, Yosuke Uchitomi, Maiko Fujimori, Toshihiro Koyama, Hitomi Kataoka, Yoshihisa Kitamura, Toshiaki Sendo, Masatoshi Inagaki

    INTERNATIONAL JOURNAL OF CLINICAL PHARMACY   37 ( 6 )   1258 - 1266   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Background Pharmacists are expected to play a key role in modern cancer care. Research suggests that an empathic approach and attitude in medical staff improves the quality of patient care. An empathic attitude and psychological distress are thought to be associated with autistic-like traits, but little is known about such traits. Objective In this study, we aimed to clarify the associations among autistic-like traits, empathic attitude in a medical context, and psychological health in hospital pharmacists. Setting Eligibility criteria for inclusion were certified pharmacists working at hospitals for patient care who returned their questionnaires. Method Eight hundred and twenty-three hospital pharmacists completed a number of self-administered questionnaires anonymously by mail. Main outcome measures Scores were obtained on the Autism-Spectrum Quotient, the Jefferson Scale of Empathy, the General Health Questionnaire-12, and subscales of the Interpersonal Reactivity Index (Perspective Taking, IRI-Empathic Concern, IRIPersonal Distress). We performed correlation and mediation analyses to confirm that the empathy and general health questionnaires were associated with autism-spectrum quotient scores, and with each IRI subscale. Results Complete responses were obtained from 379 pharmacists comprising 151 males (39.8 %) with a mean age of 37.7 +/- A 10.8 years (missing data, n = 13) and a median of 11 years after qualification as a pharmacist. Autism-Spectrum Quotient scores were inversely correlated with empathy (r = -0.22, p < 0.001) and positively correlated with general health scores (r = 0.40, p < 0.001). In the models with mediation, the inverse correlation between autism-spectrum quotient and empathy scores was mediated indirectly by IRI-Perspective Taking and IRI-Empathic Concern, and the positive correlation between autism-spectrum quotient and general health was mediated indirectly by IRI-Personal Distress. There were also direct effects, with significant effects of autism-spectrum quotient on empathy and general health scores. Conclusion Our findings suggest that autistic-like traits affect both empathic attitude in a medical context and the psychological health of pharmacists. We recommend that to improve empathy in those with high levels of autistic-like traits, we may need to develop specialized interventions, such as improving communication skills training.

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  • The Effectiveness of Team-based Learning (TBL) as a New Teaching Approach for Pharmaceutical Care Education 査読

    Manabu Suno, Toshiko Yoshida, Toshihiro Koyama, Yoshito Zamami, Tomoko Miyoshi, Takaaki Mizushima, Mitsune Tanimotoa

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   133 ( 10 )   1127 - 1134   2013年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The concept of Team-Based Learning (TBL) was developed in the late 1970s by Larry Michaelsen, who wanted students to enjoy the benefits of small group learning within large classes in the business school environment. In contrast to problem-based learning (PBL), which is student centered, TBL is typically instructor centered. Recently, TBL is being used as a teaching method in over 60 health science professional schools in the US and other countries. In the present study, the impact of adopting TBL in teaching pharmaceutical care practices to students was evaluated. Students were required to answer a set of multiple-choice questions individually in individual readiness assessment test (IRAT) before the TBL sessions to assess their level of preparation. The same set of questions was then reattempted by the group readiness assessment test (GRAT) during TBL. Comparing the scores obtained in the GRAT and IRAT before the first TBL session, the scores from the GRAT were always higher than those of the IRAT, indicating that TBL has encouraged active learning. In addition, students were surveyed about their level of satisfaction with TBL and written comments about TBL were solicited. The results of the questionnaire showed that 87.3 +/- 9.3% of the students were satisfied. Moreover, no student commented that TBL was in any way inferior to the PBL. Implementation of a TBL approach was successfully integrated into the pharmaceutical care education course. In order to further improve the usefulness of TBL in teaching pharmaceutical care, a hybrid teaching approach that also comprises PBL and a lecture-based course is desirable.

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  • Effect of the 5-HT1A receptor function on antidepressive effect and neurogenesis in ACTH treated rats 査読

    Miyake Ayaka, Kitamura Yoshihisa, Hattori Sayo, Koyama Toshihiro, Miyazaki Ikuko, Asanuma Masato, Sendo Toshiaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   121   144P   2013年

  • The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats 査読

    Keiko Kuwatsuka, Hiromi Hayashi, Yuka Onoue, Ikuko Miyazaki, Toshihiro Koyama, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

    Journal of Pharmacological Sciences   122 ( 1 )   34 - 41   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In clinical studies, electroconvulsive stimuli have been associated with improvements in both depression and treatment-resistant depression. In a previous study, treatment with adrenocorticotropic hormone (ACTH) for 14 days decreased adult hippocampal cell proliferation. Furthermore, electroconvulsive stimuli significantly decreased the duration of immobility following repeated administration of ACTH for 14 days in rats. The present study was undertaken to further characterize the mechanism of treatment-resistant antidepressant effects of electroconvulsive stimuli by measuring cell proliferation, brain-derived neurotrophic factor (BDNF) levels, and phosphorylated and total cyclic adenosine monophosphate (cAMP) response element-binding protein (pCREB/CREB) levels in the hippocampus of ACTH-treated rats. Electroconvulsive stimuli increased cell proliferation in both saline-treated and ACTH-treated rats. Mature-BDNF protein levels showed a tendency to decrease in ACTH-treated rats. Electroconvulsive stimuli treatment increased mature-BDNF protein levels in the hippocampus of both saline-treated and ACTH-treated rats. Furthermore, electroconvulsive stimuli increased phospho-Ser133-CREB (pCREB) levels and the ratio of pCREB/CREB in both saline-treated and ACTH-treated rats. These findings suggest that the treatment-resistant antidepressant effects of electroconvulsive stimuli may be attributed, at least in part, to an enhancement of hippocampal cell proliferation. © The Japanese Pharmacological Society.

    DOI: 10.1254/jphs.13015FP

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  • Influence of doxorubicin and cyclophosphamide on psychological behavior in rats 査読

    Kitamura Yoshihisa, Hattori Sayo, Miyake Ayaka, Koyama Toshihiro, Miyazaki Ikuko, Asanuma Masato, Sendo Toshiaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   121   143P   2013年

  • Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries 査読

    Honghua Jin, Pengyuan Sun, Shingo Takatori, Toshihiro Koyama, Yoshito Zamami, Panot Tangsucharit, Yoshihisa Kitamura, Hiromu Kawasaki

    EUROPEAN JOURNAL OF PHARMACOLOGY   680 ( 1-3 )   73 - 80   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    A previous report showed that histamine in denuded mesenteric vascular beds produced a triphasic response; an initial small histamine H-2 receptor-mediated vasodilation, a transient histamine H-1 receptor-mediated vasoconstriction, and finally a long-lasting vasodilation. We further investigated the vascular effect of histamine in mesenteric preparations without an endothelium to clarify the possible involvement of perivascular nerves. Male Wistar rat mesenteric vascular beds without an endothelium were perfused with Krebs solution containing methoxamine to produce active tone and lafutidine to block histamine H-2 receptor-mediated vasodilation. Histamine (1-100 mu M) was perfused for 1 min and perfusion pressure was measured with a pressure transducer. Histamine caused a biphasic vascular response; initial vasoconstriction followed vasodilation. Tetrodotoxin (a neurotoxin, 1 mu M) and procaine (a local anesthetic, 100 mu M) significantly inhibited the vasoconstriction and vasodilation. Ruthenium red (a transient receptor potential vanilloid 1 (TRPV1) antagonist, 1 mu M) also significantly inhibited both phases of the response. Pretreatment with capsaicin (a depletor of calcitonin gene-related peptide (CGRP)-containing nerves, 5 mu M) significantly inhibited the vasodilation without affecting the initial vasoconstriction. Both indomethacin (a cyclooxygenase inhibitor, 0.5 mu M) and seratrodast (a thromboxane A(2) receptor antagonist, 0.1 mu M) abolished the histamine-induced vasoconstriction and subsequent vasodilation. These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves. They also suggest that perivascular nerves and prostanoids, probably thromboxane A(2), are responsible for the vascular response to histamine. (C) 2012 Elsevier B. V. All rights reserved.

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  • Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries 査読

    Yuto Haruki, Shingo Takatori, Sayo Hattori, Yoshito Zamami, Toshihiro Koyama, Panot Tangsucharit, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   118 ( 4 )   537 - 542   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 - 4 Hz) induced only adrenergic nerve-mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.

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  • Investigation on the Mechanisms for the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in ACTH Treated Rats 査読

    Hiromi Hayashi, Maho Doi, Yuka Onoue, Keiko Kuwatsuka, Ayaka Miyake, Toshihiro Koyama, Kazuaki Shinomiya, Ikuko Miyazaki, Masato Aasanuma, Yoshihisa Kitamura

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   132 ( 2 )   173 - 178   2012年2月

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    記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    We previously reported that adrenocorticotropic hormone (ACTH) -treated rats serve as a valuable animal model for tricyclic antidepressant-resistant depressive conditions. The present study was undertaken to investigate the changes in neurogenesis in the hippocampus of ACTH-treated rats. Chronic treatment of ACTH decreased the number of bromodeoxyuridine-labeled cells in the dentate gyrus, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. Furthermore, chronic ACTH treatment also decreased the expression of brain-derived neurotrophic factor, and the coadministration of imipramine and lithium, and electroconvulsive stimuli recovered these reductions. These results suggest that antidepressant-resistant depression is caused by the suppression of neurogenesis, and the coadministration of imipramine and lithium, and electroconvulsive stimuli exert an antidepressant-like effect by recovering proliferative signals and neurogenesis.

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  • Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients 査読

    Junko Ohnishi, Akiyo Miyake, Keiko Kuwatsuka, Yuka Onoue, Miyoshi Lee, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Yoshihisa Kitamura

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   34 ( 10 )   1609 - 1612   2011年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The initiation of a pharmacist-implemented management program to ensure appropriate use of erythropoietin-stimulating agents at Mizushima Kyodo Hospital is described. In the present study, we examined the influence of having pharmacists actively manage hemoglobin levels on therapeutic outcome in a retrospective study of 84 outpatients receiving hemodialysis. We compiled in-hospital guidelines for the use of erythropoietin and iron for outpatients with renal anemia. Pharmacists made recommendations, particularly about changes in the dose of erythropoietin and administration of iron preparations, to physicians. Clinical test results were monitored for 12 months (between November 2007 and October 2008) with and without the participation of pharmacists (continuous 6 months). The counseling by pharmacists significantly decreased hemoglobin levels in the high group (&gt;12 g/dl) and significantly increased them in low group (&lt;10 g/dl). Furthermore, it increased hemoglobin levels in the optimal group, suggesting the management of our hospital guidelines. On the other hand, low levels of hemoglobin indicated low levels of albumin. It is suggested that no improvement in hemoglobin levels may indicate low levels of albumin. These findings suggest that the active participation of pharmacists in the management of renal anemia in hemodialysis patients had a great therapeutic impact.

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  • Histamine H-3 receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries 査読

    Pengyuan Sun, Shingo Takatori, Xin Jin, Toshihiro Koyama, Panot Tangsucharit, Simin Li, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

    EUROPEAN JOURNAL OF PHARMACOLOGY   655 ( 1-3 )   67 - 73   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The rat mesenteric artery has been shown to be innervated by adrenergic vasoconstrictor nerves and calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves. The present study was designed to investigate the involvement of histamine H-3 receptors in the neurotransmission of perivascular adrenergic and CGRPergic nerves. The mesenteric vascular beds without an endothelium isolated from male Wistar rats were perfused with Krebs solution and perfusion pressure was measured. In preparations with resting tension, the selective H-3 receptor agonist (R)-alpha-methylhistamine (alpha-methylhistamine; 10-100 nM) significantly reduced periarterial nerve stimulation (2-8 Hz)-induced vasoconstriction and noradrenaline release in the perfusate without an effect on the vasoconstriction induced by exogenously injected noradrenaline (0.5, 1.0 nmol). In preparations with active tone produced by methoxamine (2 mu M) and in the presence of guanethidine (5 mu M), the periarterial nerve stimulation (1, 2 Hz)-induced vasodilator response was inhibited by a-methylhistamine (0.1-1 mu M) perfusion without affecting vasodilation induced by exogenously injected CGRP (5 pmol). Clobenpropit (histamine H-3 receptor antagonist, 1 mu M) canceled the alpha-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation. These results suggest that the stimulation of H-3 receptors located in rat perivascular nerves inhibits presynaptically the neurotransmission of not only adrenergic nerves, but also CGRP nerves, by decreasing neurotransmitters. (C) 2011 Elsevier B.V. All rights reserved.

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  • Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats 査読

    Yoshihisa Kitamura, Maho Doi, Keiko Kuwatsuka, Yuka Onoue, Ikuko Miyazaki, Kazuaki Shinomiya, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   34 ( 1 )   77 - 81   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Adult hippocampal neurogenesis is reported to change in animal models of depression and antidepressants. We have used the mitotic marker 5-bromo-2'-deoxyyridine to address the effects of imipramine and lithium on cell proliferation and survival following chronic treatment with adrenocorticotropic hormone (ACTH) in the subgranular zone of the hippocampal dentate gyrus. ACTH treatment for 14d decreased adult hippocampal cell proliferation and survival. Coadministration of imipramine and lithium for 14d blocked the loss of cell proliferation but not cell survival resulting from the chronic treatment with ACTH. The coadministration of imipramine and lithium may have treatment-resistant antidepressive properties, which may be attributed, in part, to a normalization of hippocampal cell proliferation.

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  • Paracrine control of mesenteric perivascular axo-axonal interaction. 査読

    H Kawasaki, S Takatori, 座間味 義人, T Koyama, M Goda, K Hirai, P Tangsucharit, X Jin, N Hobara, Y Kitamura

    Acta Physiologica   Vol.203 ( No.1 )   3 - 11   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Immunohistochemical study of rat mesenteric arteries showed dense innervation of adrenergic nerves, calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves), nitric oxide-containing nerves (nitrergic nerves). Double-immunostaining revealed that most CGRPergic or nitrergic nerves were in close contact with adrenergic nerves. CGRPergic and transient receptor potential vanilloid-1 (TRPV1)-immunopositive nerves appeared in the same neurone. In rat perfused mesenteric vascular beds without endothelium and with active tone, perfusion of nicotine, or bolus injection of capsaicin and acetylcholine and periarterial nerve stimulation (PNS) lowered pH levels of out flowed perfusate concomitant with vasodilation. Cold-storage denervation of preparations abolished pH lowering induced by nicotine and PNS. Guanethidine inhibited PNS- and nicotine-, but not acetylcholine- and capsaicin-, induced pH lowering. Pharmacological analysis showed that protons were released not only from adrenergic nerves but also from CGRPergic nerves. A study using a fluorescent pH indicator demonstrated that nicotine, acetylcholine and capsaicin applied outside small mesenteric artery lowered perivascular pH levels, which were not observed in Ca(2+) free medium. Exogenously injected hydrochloric acid in denuded preparations induced pH lowering and vasodilation, which was inhibited by denervation, TRPV1 antagonists and capsaicin without affecting pH lowering. These results suggest that excitement of adrenergic nerves releases protons to activate TRPV1 in CGRPergic nerves and thereby induce vasodilation. It is also suggested that CGRPergic nerves release protons with exocytosis to facilitate neurotransmission via a positive feedback mechanism.

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  • Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats 査読

    Toshihiro Koyama, Yukako Hatanaka, Xin Jin, Ayako Yokomizo, Hidetoshi Fujiwara, Mitsuhiro Goda, Narumi Hobara, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

    HYPERTENSION RESEARCH   33 ( 5 )   485 - 491   2010年5月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Neuronal nitric oxide (NO) has been shown to modulate perivascular adrenergic neurotransmission by inhibiting noradrenaline release from terminals in rat mesenteric arteries. This study was conducted to investigate changes in the inhibitory function of NO-containing nerves (nitrergic nerves) in mesenteric vascular beds of 2-kidney, 1-clip renovascular hypertensive rats (2K1C-RHR). Rat mesenteric vascular beds without endothelium were perfused with Krebs solution and the perfusion pressure was measured. In preparations from sham-operated rats (control) and 2K1C-RHRs, vasoconstriction induced by periarterial nerve stimulation (PNS; 2-8 Hz), but not vasoconstriction induced by exogenously injected noradrenaline (0.5, 1.0 nmol), was markedly facilitated in the presence of a nonselective NO synthase (NOS) inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME) (100 mu M). The facilitatory effect of L-NAME in preparations from 2K1C-RHR was smaller than that in control preparations. L-NAME augmented PNS-evoked noradrenaline release, which was smaller in 2K1C-RHRs than in controls. The expression of neuronal NO synthase (nNOS) measured by western blotting in mesenteric arteries from 2K1C-RHRs was significantly decreased compared with control arteries. Immunohistochemical staining of mesenteric arteries showed dense innervation of nNOS-immunopositive nerves that was significantly smaller in arteries from 2K1C-RHR than that in control arteries. Mesenteric arteries were densely innervated by tyrosine hydroxylase-immunopositive nerves, which coalesced with nNOS-immunopositive nerves. These results suggest that the inhibitory function of nitrergic nerves in adrenergic neurotransmission is significantly decreased in 2K1C-RHRs. This functional alteration based on the decrease in nNOS expression and nitrergic innervation leads to enhanced adrenergic neurotransmission and contributes to the initiation and development of renovascular hypertension. Hypertension Research (2010) 33, 485-491; doi: 10.1038/hr.2010.48; published online 9 April 2010

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  • Endothelial Modulation of Agonist-induced Vasoconstriction in Mesenteric Microcirculation 査読

    Xin Jin, Yukiko Otonashi-Satoh, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   130 ( 5 )   723 - 728   2010年5月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    It is widely accepted that vascular endothelium regulates vasoconstriction via release of endothelium-derived relaxing factors (EDRF). The mesenteric circulation, which is the largest vascular bed, influences regulation of systemic blood pressure. However, the role of EDRF in the modulation of vascular tone in peripheral mesenteric circulation has not been extensively studied. Therefore, our recent studies investigated the role of the vascular endothelium in the regulation of methoxamine (alpha(1)-adrenoceptor agonist)-induced vasoconstriction and their age-related changes in rat mesenteric vascular beds. In mesenteric vascular beds with intact endothelium isolated from 8 week-old rats, the initial maximum vasoconstriction induced by continuous perfusion of methoxamine was time-dependently decreased during 3 hour-perfusion. Neither nitric oxide synthase inhibitor nor cyclooxygenase inhibitor altered this time-dependent reduction of methoxamine-induced vasoconstriction. Endothelium removal, K+-channel inhibitors and gap junction inhibitor significantly inhibited the time-dependent reduction of methoxamine-induced vasoconstriction. In the preparations with intact endothelium from 16 week-old rats, the time-dependent reduction of methoxamine-induced vasoconstriction disappeared. Furthermore, endothelium removal and treatment with cyclooxygenase inhibitor, thromboxane A(2) receptor antagonist or superoxide dismutase mimetic significantly reduced the methoxamine-induced vasoconstriction in the preparations from 16 week-old rats. These findings suggest that vascular endothelium acts to depress methoxamine-induced vasoconstriction by releasing endothelium-derived hyperpolarizing factor (EDHF), and dysfunction in this endothelial modulation develops with ageing.

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  • R-(-)-alpha-Methylhistamine, a Histamine H-3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries 査読

    Pengyuan Sun, Xin Jin, Toshihiro Koyama, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   33 ( 1 )   58 - 63   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    A novel histamine receptor subtype, histamine H-3 receptor, mediates inhibition of peripheral autonomic neurotransmission. The present study was designed to examine vascular effects of histamine H-3 receptor by using a selective histamine H-3 receptor agonist, R-(-)-alpha methylhistamine (alpha-methylhistamine), in rat mesenteric resistance arteries. The isolated mesenteric vascular beds were perfused with Krebs solution and perfusion pressure was measured. Active tone was produced by perfusion of Krebs solution containing 7 mu M methoxamine. In preparations with intact endothelium, perfusion of alpha-methylhistamine (1-100 mu M) for 1 min produced a concentration-dependent vasodilation. The maximum vasodilation at the highest concentration was approximately 45%. This vasodilation was abolished by endothelium removal and attenuated by histamine H-3 receptor antagonists, thioperamide and clobenpropit, but not by chlorpheniramine (histamine H-1 receptor antagonist) and cimetidine (histamine H-2 receptor antagonist). N-omega-nitro-L-arginine methyl ester (L-NAME, nitric oxide (NO) synthase inhibitor), indomethacin (cyclooxygenase inhibitor) and tetraethylammonium (nonselective K+-channel blocker) and high KCl (30 mM) significantly inhibited alpha-methylhistamine-induced endothelium-dependent vasodilation. These findings suggest that alpha-methylhistamine induces endothelium-dependent vasodilation mainly via endothelium histamine H-3 receptors. It is also suggested that activation of histamine H-3 receptors in the endothelium releases mainly NO and partially prostaglandin I-2 and endothelium-derived hyperpolarizing factors to induce endothelium-dependent vasodilation.

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  • Chronic hyperinsulinemia induces hypertension resulted from abnormal innervation of perivascular nerves in rat mesenteric resistance arteries 査読

    Yoshito Zamami, Shingo Takatori, Nana Yabumae, Miho Hosoda, Toshihiro Koyama, Xin Jin, Narumi Hobara, Kenji Sasaki, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   76P - 76P   2010年

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    記述言語:英語   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds 査読

    Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   111 ( 4 )   372 - 380   2009年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    We previously reported that endothelium-derived hyperpolarizing factor (EDHF)mediated response time-dependently suppressed methoxamine-induced vasoconstriction in mesenteric vascular beds isolated from 8-week-old rats. We investigated age-related changes in endothelial regulation of methoxamine-induced vasoconstriction. Mesenteric vascular beds isolated from young (8-week-old) to adult (16-week-old) rats were perfused, and changes in perfusion pressure induced by continuous perfusion of methoxamine or high KCl (60 mM) were measured over 180 min. In young preparations with intact endothelium, methoxamine-induced vasoconstriction time-dependently decreased to 20% of the initial levels, while time-dependent reduction was not observed in adult preparations. High KCl-induced vasoconstriction in young and adult preparations did not show time-dependent reduction. Endothelium removal abolished time-dependent reduction of methoxamine-induced vasoconstriction in young preparations and significantly attenuated vasoconstriction in adult preparations. Indomethacin, seratrodast, or tempol but not catalase significantly reduced methoxamine-induced vasoconstriction in adult preparations with endothelium. A23187 (Ca(2+)-ionophore)-, but not acetylcholine-, induced endothelium-dependent vasodilation in the presence of N(G)-L-nitro arginine methyl ether in adult preparations was significantly smaller than that in young preparations. These findings suggest that the inhibitory effect of mesenteric vascular endothelium on methoxamine-induced vasoconstriction disappears with aging by reducing EDHF and increasing endothelium-derived contracting factors and reactive oxygen species.

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  • Proton Acts as a Neurotransmitter for Nicotine-Induced Adrenergic and Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in the Rat Mesenteric Artery 査読

    Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshihiro Koyama, Xin Jin, Yoshihisa Kitamura

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   330 ( 3 )   745 - 755   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS  

    Nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter(s) that activate transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerves, resulting in vasodilation. The present study investigated a potential transmitter transmitting between perivascular adrenergic nerves and CGRPergic nerves. Rat mesenteric vascular beds without endothelium were contracted by perfusion with Krebs&apos; solution containing methoxamine, and the perfusion pressure and pH levels of the perfusate were measured. Nicotine perfusion for 1 min induced concentration-dependent vasodilation and lowered pH levels, which were abolished by cold-storage denervation of preparations, guanethidine (adrenergic neuron blocker), and mecamylamine (nicotinic alpha(3)beta(4)-acetylcholine receptor antagonist). Capsazepine (TRPV1 antagonist) blunted nicotine-induced vasodilation, but had no effect on the reduction of pH. Injection of hydrochloric acid (HCl) and perfusion of Krebs&apos; solution at low pH (6.0-7.2) induced vasodilation. HCl-induced vasodilation was inhibited by cold-storage denervation, capsazepine, capsaicin (CGRP depletor), and CGRP(8 37) (CGRP receptor antagonist). Perfusion of adrenergic transmitter metabolites (normetanephrine and 3-methoxydopamine), but not of other metabolites, induced vasodilation, which was not inhibited by capsaicin treatment. Immunohistochemical staining of mesenteric arteries showed dense innervation of CGRP-and TRPV1-immunopositive nerves, with both immunostainings appearing in the same neuron. Mesenteric arteries were densely innervated by neuropeptide Y-immunopositive nerves, which coalesced with CGRP-immunopositive nerves. Scanning and immunoscanning electron microscopic images showed coalescence sites of different perivascular fibers before they intruded into smooth muscles. These results indicate that nicotine initially stimulates adrenergic nerves via nicotinic alpha(3)beta(4)-receptors to release protons and thereby induces CGRPergic nerve-mediated vasodilation via TRPV1.

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  • 腎血管性高血圧における血管周囲神経の機能変化 査読

    小山 敏広, 畑中 由香子, 合田 光寛, 座間味 義人, 芳原 成美, 川崎 博己

    薬学雑誌   129 ( 2 )   185 - 189   2009年2月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • Functional Alteration of Nervous System in Renovascular Hypertension 査読

    Toshihiro Koyama, Yukako Hatanaka, Mitsuhiro Goda, Yoshito Zamami, Narumi Hobara, Hiromu Kawasaki

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   129 ( 2 )   185 - 189   2009年2月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and sham-operated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect Of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results Suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.

    DOI: 10.1248/yakushi.129.185

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  • Young Pharmacological Researchers Develop the Way to Drug Discovery Based on Interpretation of Diseases and Medicinal Assessment: The Way to Create New Drugs by Fields Interchange Foreword 査読

    Toshihiro Koyama, Sokichi Honda

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   129 ( 2 )   183 - 183   2009年2月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    DOI: 10.1248/yakushi.129.183

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  • Changes in neuronal regulation of vascular tone and its pathophysiological role in diabetic state 査読

    Yoshito Zamami, Shingo Takatori, Yukiko Iwatani, Xin Jin, Toshihiro Koyama, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   25P - 25P   2009年

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    記述言語:英語   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed 査読

    Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

    BRITISH JOURNAL OF PHARMACOLOGY   155 ( 6 )   826 - 836   2008年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Background and purpose: A ketolide antibiotic, telithromycin, has side effects including temporary loss of consciousness in clinical use, but the underlying mechanisms remain unclear. This study investigated the effects of telithromycin on perivascular nerve function in rat mesenteric arteries, in comparison with those of macrolide (erythromycin and clarithromycin) and new quinolone antibiotics (levofloxacin and gatifloxacin).
    Experimental approach: In vitro, vascular responses and release of noradrenaline induced by periarterial nerve stimulation (PNS) of rat perfused mesenteric vascular beds were measured in the presence of each antibiotic. In vivo blood pressure measurement was performed in Wistar rats.
    Key results: In mesenteric preparations with resting tone, telithromycin (10 nM-10 mu M) markedly inhibited PNS (4 -12 Hz)-induced adrenergic nerve- and exogenous noradrenaline-mediated vasoconstriction, whereas the other antibiotics slightly inhibited PNS-induced responses without affecting noradrenaline-induced responses. Telithromycin significantly reduced PNS (12Hz)-evoked noradrenaline release in the perfusate. In pre-constricted preparations with or without endothelium, telithromycin (0.1 nM-10 mu M) caused a concentration-dependent vasodilation. Telithromycin (10 nM) inhibited calcium-induced vasoconstriction in high KCl and calcium-free medium. None of the antibiotics used affected PNS (0.5-2 Hz)-induced calcitonin gene-related peptide (CGRP) nerve- and exogenous CGRP-mediated vasodilation. Intravenous injection of telithromycin significantly lowered blood pressure in anaesthetized rats.
    Conclusions and implications: These results suggest that telithromycin causes not only strong inhibition of perivascular adrenergic neurotransmission but also a vasodilator action in mesenteric vascular beds and hypotension. It is thus possible that telithromycin increases visceral blood flow, consequently reducing cerebral blood flow and resulting in a temporary loss of consciousness.

    DOI: 10.1038/bjp.2008.313

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  • Royal jelly ameliorates insulin resistance in fructose-drinking rats. 査読

    Yoshito Zamami, Shingo Takatori, Mitsuhiro Goda, Toshihiro Koyama, Yukiko Iwatani, Xin Jin, Shima Takai-Doi, Hiromu Kawasaki

    Biological & pharmaceutical bulletin   31 ( 11 )   2103 - 7   2008年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.

    DOI: 10.1248/bpb.31.2103

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  • A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed 査読

    Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

    British Journal of Pharmacology   155 ( 6 )   826 - 836   2008年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and purpose: A ketolide antibiotic, telithromycin, has side effects including temporary loss of consciousness in clinical use, but the underlying mechanisms remain unclear. This study investigated the effects of telithromycin on perivascular nerve function in rat mesenteric arteries, in comparison with those of macrolide (erythromycin and clarithromycin) and new quinolone antibiotics (levofloxacin and gatifloxacin). Experimental approach: In vitro, vascular responses and release of noradrenaline induced by periarterial nerve stimulation (PNS) of rat perfused mesenteric vascular beds were measured in the presence of each antibiotic. In vivo blood pressure measurement was performed in Wistar rats. Key results: In mesenteric preparations with resting tone, telithromycin (10 nM-10 μM) markedly inhibited PNS (4-12 Hz)-induced adrenergic nerve- and exogenous noradrenaline-mediated vasoconstriction, whereas the other antibiotics slightly inhibited PNS-induced responses without affecting noradrenaline-induced responses. Telithromycin significantly reduced PNS (12 Hz)-evoked noradrenaline release in the perfusate. In pre-constricted preparations with or without endothelium, telithromycin (0.1 nM-10 μM) caused a concentration-dependent vasodilation. Telithromycin (10 nM) inhibited calcium-induced vasoconstriction in high KCl and calcium-free medium. None of the antibiotics used affected PNS (0.5-2 Hz)-induced calcitonin gene-related peptide (CGRP) nerve- and exogenous CGRP-mediated vasodilation. Intravenous injection of telithromycin significantly lowered blood pressure in anaesthetized rats. Conclusions and implications: These results suggest that telithromycin causes not only strong inhibition of perivascular adrenergic neurotransmission but also a vasodilator action in mesenteric vascular beds and hypotension. It is thus possible that telithromycin increases visceral blood flow, consequently reducing cerebral blood flow and resulting in a temporary loss of consciousness. © 2008 Macmillan Publishers Limited All rights reserved.

    DOI: 10.1038/bjp.2008.313

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  • Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries 査読

    Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   108 ( 1 )   95 - 103   2008年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    Vascular endothelium regulates vascular tone by releasing endothelium-derived vasoactive substances. We performed this study to characterize the Inhibitory effect of the endothelium on vasoconstrictor stimuli in rat mesenteric vascular beds. Changes in perfusion pressure induced by continuous perfusion of Krebs solution containing methoxamine (alpha(1)-adrenoceptor agonist) or high KCl were measured over 180 min. In preparations with intact endothelium, methoxamine-Induced vasoconstriction was time-dependently decreased to cause 60%-80% reduction of the initial vasoconstriction level, while no reduction was observed in high-KCl-induced vasoconstriction. Endothelium removal significantly blunted the time-dependent reduction of methoxamine-induced vasoconstriction without affecting high-KCl-induced vasoconstriction. Neither a nitric oxide synthase inhibitor (L-NAME) nor indomethacin (cyclooxygenase inhibitor) altered the time-dependent reduction of vasoconstriction. High KCl, K+-channel inhibitors tetraethylammonium and apamin plus charybdotoxin, and 18 alpha-glycyrrhetinic acid (18 alpha-GA, a gap-junction inhibitor) significantly inhibited the time-dependent reduction of methoxamine-induced vasoconstriction. In preconstricted preparations, bolus injection of acetylcholine and Ca2+-ionophore A23187 (A23187) evoked a sharp vasodilation, which was inhibited by endothelium removal, high KCl and tetraethylammonium, but not indomethacin, L-NAME, or 18 alpha-GA. However, 18 alpha-GA plus L-NAME inhibited vasodilation induced by A23187, but not acetylcholine. These findings suggest that endothelium-derived hyperpolarizing factor (EDHF) via gap junctions mainly counteracts vasoconstriction induced by methoxamine in mesenteric resistance arteries.

    DOI: 10.1254/jphs.08115FP

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  • [Effect of propolis on insulin resistance in fructose-drinking rats]. 査読

    Yoshito Zamami, Shingo Takatori, Toshihiro Koyama, Mitsuhiro Goda, Yukiko Iwatani, Shima Doi, Hiromu Kawasaki

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   127 ( 12 )   2065 - 73   2007年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8 Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.

    DOI: 10.1248/yakushi.127.2065

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  • Histamine-induced vasodilation and vasoconstriction in the mesenteric resistance artery of the rat 査読

    H Jin, T Koyama, Y Hatanaka, S Akiyama, F Takayama, H Kawasaki

    EUROPEAN JOURNAL OF PHARMACOLOGY   529 ( 1-3 )   136 - 144   2006年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The present study was designed to examine the vascular response to histamine in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, perfusion of histamine (1 nM-100 mu M) produced a concentration-dependent vasodilation. Histamine-induced vasodilation was attenuated by L-NAME (nitric oxide (NO) synthase inhibitor, 100 mu M) and olopatadine (histamine H, receptor antagonist, 1 mu M) but not by laftitidine (histamine H-2 receptor antagonist, 1 mu M). Cold-storage denervation (4 degrees C for 72 h) of the preparation with intact endothelium attenuated the histamine-induced vasodilation. In preparations without endothelium, histamine at low concentrations (1-100 nM) produced only a small and rapid vasodilation, whereas histamine at concentrations higher than 1 mu M produced triphasic vascular responses: initial sharp vasodilation followed by transient vasoconstriction and subsequent gradual vasodilation. Lafutidine abolished only the histamine-induced initial vasodilation. Olopatadine abolished the histamine-induced second vasoconstriction and third vasodilation. Cold-storage denervation of the denuded preparation abolished the histamine-induced second vasoconstriction and third vasodilation. These findings suggest that histamine induced endothelium-dependent vasodilation via endothelium histamine H-1 receptors and endothelium-independent vasodilation via smooth muscle histamine H-2 receptors. It is also suggested that the histamine-induced endothelium-independent vasoconstriction and vasodilation are mediated by histamine H-1 receptors and perivascular nerves. (c) 2005 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.ejphar.2005.10.060

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▼全件表示

書籍等出版物

  • 救急薬学

    小山 敏広( 担当: 共著)

    京都廣川書店  2015年3月 

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  • 術後せん妄発症予防に対する薬剤師参画「せん妄対策チーム」の効果的な介入に向けた検討

    江角 悟, 四宮 一昭, 村川 公央, 住江 春香, 田村 麻衣, 小山 敏広, 牛尾 聡一郎, 井上 真一郎, 座間味 義人, 北村 佳久, 千堂 年昭

    日本病院薬剤師会雑誌   55 ( 9 )   1071 - 1076   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本病院薬剤師会  

    岡山大学病院では、せん妄対策チーム(Delirium Management and Assessment Center:以下、D-mac)を立ち上げ、薬剤師を含む多職種が連携して術後せん妄発症予防に取り組んでいる。D-macでは発足当初から睡眠薬使用に関するアルゴリズムを作成し、せん妄発症リスクの高いベンゾジアゼピン系睡眠薬の使用を中止し、トラゾドンへの切り替えを推奨してきた。本研究ではせん妄発症ハイリスク患者を対象とした本アルゴリズム導入による術後のせん妄および不眠発症状況の調査を行った。その結果、D-mac発足前と比べD-mac発足により術後せん妄発症率が減少したが、一方で術後不眠発症率は増加していた。そこでアルゴリズムを改訂し常用している睡眠薬は手術後も継続したところ、術後せん妄の発症予防効果に加えて術後不眠発症率の減少が認められた。以上の結果から、D-macによる改訂版の不眠時推奨アルゴリズムはせん妄発生の低減並びに周術期の不眠予防にも有効であることが示された。(著者抄録)

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  • 心肺停止患者における生存率の向上を志向したドラッグリポジショニング研究 大規模医療情報を活用した検討

    座間味 義人, 新村 貴博, 武智 研志, 今西 正樹, 小山 敏広, 石澤 啓介

    薬学雑誌   137 ( 12 )   1439 - 1442   2017年12月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

    近年、既存薬の新しい薬効を発見し、それを別の疾患の治療薬として開発するドラッグリポジショニングという創薬戦略が提案されている。ドラッグリポジショニングでは、安全性を確保しながら開発期間を短縮することが可能であり、新規化合物に比べ開発成功率も高くなる。心肺停止患者の生存率を向上させることを目的として、ドラッグリポジショニングの創薬戦略により実施した大規模データベースを紹介し、今後の展望についても考察した。

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  • 大規模医療情報に基づく炭酸リチウムの適正使用に関する検討

    大島 礼子, 小山 敏広, 藤井 里可, 坂本 敦勇, 樋之津 史郎, 狩野 光伸

    日本薬学会年会要旨集   137年会 ( 4 )   60 - 60   2017年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • 新規心肺蘇生薬の開発を目指したドラッグリポジショニング研究

    座間味義人, 今西正樹, 武智研志, 小山敏広, 大島礼子, 樋之津史郎, 狩野光伸, 石澤啓介

    日本高血圧学会総会プログラム・抄録集   39th   437   2016年9月

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    記述言語:日本語  

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  • 救急医療における薬剤師の可能性を考える 臨床現場の薬剤師活動と大学教育を融合し救急医療に精通した薬剤師を育成するには 救急医療における薬物治療に主眼を置いた薬学教育

    座間味 義人, 小山 敏広, 今井 徹, 武本 あかね, 相良 英憲, 千堂 年昭, 名倉 弘哲

    薬学雑誌   136 ( 7 )   987 - 991   2016年7月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • エダラボンによる急性腎障害発現の危険因子解析

    座間味 義人, 相良 英憲, 萱野 由佳, 小山 敏広, 白石 奈緒子, 江角 悟, 鵜川 豊世武, 千堂 年昭, 氏家 良人, 名倉 弘哲

    日本臨床救急医学会雑誌   19 ( 3 )   461 - 465   2016年6月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床救急医学会  

    エダラボンを用いた治療は患者の神経学的予後を改善する一方、急性腎障害発現のリスクがあると報告されている。本研究はエダラボン投与による急性腎障害発現を予防するために、エダラボン投与時の患者背景から危険因子を解析することを目的とした。岡山大学病院においてエダラボンが投与された患者を対象に、患者基本情報およびエダラボン投与情報、血液検査結果を電子カルテより遡及的に調査した。調査データから単変量解析を実施し、抽出した因子を用いて二項ロジスティック回帰分析を行った結果、感染症の併発が、エダラボンによる急性腎障害発現の有意な危険因子(予測因子)であることが示唆された。したがって、感染症の所見がある患者にエダラボンを投与する際は、急性腎障害発現に留意する必要がある。(著者抄録)

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  • ドラッグリポジショニングを切り口とした新規心肺蘇生薬の探索研究―大規模医療情報を活用した検討―

    座間味義人, 今西正樹, 武智研志, 小山敏広, 大島礼子, 今井徹, 樋之津史郎, 狩野光伸, 石澤啓介, 石澤啓介

    医療薬学フォーラム講演要旨集   24th   193   2016年6月

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    記述言語:日本語  

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  • 術後せん妄発症予防に対する「せん妄対策チーム」の効果的な介入に向けた取り組み~術後患者の睡眠状況からのアプローチ~

    住江春香, 村川公央, 村川公央, 井上真一郎, 土山璃沙, 田村麻衣, 河本紫帆, 本郷志帆, 小山敏広, 馬場華奈己, 小田幸治, 伊藤真理, 足場孝子, 四宮一昭, 北村佳久, 北村佳久, 千堂年昭, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   136th ( 4 )   ROMBUNNO.27AB‐AM412S - 153   2016年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • レセプトデータを利用したピボキシル基含有抗菌剤による小児低血糖の発生頻度に関する研究

    建部泰尚, 建部泰尚, 白石奈緒子, 小山敏広, 村川公央, 北村佳久, 樋之津史郎, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   136th ( 4 )   ROMBUNNO.27AB‐AM088 - 99   2016年3月

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  • 非ビタミンK阻害経口抗凝固薬の有効性と安全性に関する臨床疫学研究

    大島礼子, 小山敏広, 座間味義人, 小川愛子, 森田瑞樹, 冨田秀太, 樋之津史郎, 狩野光伸

    日本計量生物学会年会講演予稿集   2016   41‐46   2016年

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    記述言語:日本語  

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  • がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究 抗がん治療の中止の際に医療者に望まれる行動に関する研究

    内富庸介, 藤森麻衣子, 梅澤志乃, 白井由紀, 稲垣正俊, 樋口裕二, 藤原雅樹, 林原千夏, 北村佳久, 小山敏広, 長坂剛夫

    がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究 平成27年度 総括・分担研究報告書   11‐13   2016年

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  • がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究 がん医療者に望まれる行動に関する研究

    稲垣正俊, 樋口裕二, 千堂年昭, 北村佳久, 小山敏広, 片岡仁美, 林原千夏, 藤森麻衣子

    がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究 平成27年度 総括・分担研究報告書   21‐23   2016年

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  • 心肺停止患者における社会復帰率の向上を志向したドラッグリポジショニング研究

    座間味義人, 座間味義人, 今西正樹, 今西正樹, 小山敏広, 大島礼子, 樋之津史郎, 狩野光伸, 石澤啓介, 石澤啓介

    日本薬学会年会要旨集(CD-ROM)   136th   ROMBUNNO.S20‐4   2016年

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  • 23-7-O62-17 経口医薬品の規格適正化がもたらす医療費削減効果の検証(薬剤疫学・医療経済,口頭発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

    白石 奈緒子, 小山 敏広, 座間味 義人, 建部 泰尚, 大島 礼子, 千堂 年昭

    日本医療薬学会年会講演要旨集   25   2015年10月

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    記述言語:日本語   出版者・発行元:日本医療薬学会  

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  • 診療情報明細書情報に基づく安全性対策効果検証の取り組み:炭酸リチウムの適正使用に関する事例を中心に

    小山敏広, 樋之津史郎, 大島礼子, 座間味義人, 白石奈緒子, 建部泰尚, 四宮一昭, 狩野光伸

    Journal of Toxicological Sciences   40 ( Supplement )   S27   2015年6月

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  • 「せん妄」発現予防並びに発現率低下に貢献する薬剤師業務プログラムの開発

    北村佳久, 内富庸介, 小山敏広, 渡邊沙織, 千堂年昭, 村川公央

    医療の広場   55 ( 3 )   14 - 17   2015年3月

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    記述言語:日本語   出版者・発行元:(公財)政策医療振興財団  

    せん妄予防・早期発見に役立つツールの開発を目的に、発症と手術後のせん妄の関連性について調査を行った。また、炎症モデル動物を作成し、その動物の行動変化よりせん妄の病態を推察した。対象は、せん妄と診断された119名(男性86名、女性33名、平均年齢70.9歳)とした。手術によるせん妄発症数は89例で、術後3日以内に発症した患者数は89例中45名(51%)、4日以降に発症した患者数は33名(37%)であった。手術部位としては消化管、肝臓、胆道などが多かった。発症時期と、平均手術時間・平均麻酔時間に関連はなく、術後の炎症状態とせん妄発症との間にも関連は認めなかった。炎症モデルとして、ICR系雄性マウスを用い、lipopolysaccharides(LPS)を投与した。さらにdiazepamを投与し、自発運動量測定および位置認知記憶試験を行い、自発運動量の変化を検討した。その結果、正常マウスでは、diazepamの亢進作用が認められたが、LPS投与後ではその亢進作用は抑制された。短期記憶試験として位置認知試験を行ったところ、位置新規物体への探索割合と比較し、diazepamの処置群では、位置新規物体に対し、有意な探索行動の低下が見られた。

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  • 救急医療における薬剤師の可能性を考える 臨床現場の薬剤師活動と大学教育を融合し救急医療に精通した薬剤師を育成するには 救急医療における薬物治療に主眼を置いた薬学教育

    座間味 義人, 小山 敏広, 今井 徹, 武本 あかね, 相良 英憲, 千堂 年昭, 名倉 弘哲

    日本薬学会年会要旨集   135年会 ( 1 )   261 - 261   2015年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • 術後せん妄発症予防に対する薬剤師参画「せん妄対策チーム」の効果的な介入に向けたリスク因子の探索~飲酒に関する患者背景・因子からのアプローチ~

    田村麻衣, 村川公央, 河本紫帆, 本郷志帆, 小山敏広, 土山璃沙, 馬場華奈己, 小田幸治, 伊藤真理, 足羽孝子, 井上真一郎, 四宮一昭, 北村佳久, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   135th ( 4 )   ROMBUNNO.26PB-AM156 - 156   2015年3月

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  • 救急医療における薬剤師業務に関する日本と諸外国との比較―よりよい救急薬剤師の確立を目指して―

    座間味義人, 今井徹, 小山敏広, 武本あかね, 北村佳久, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   135th ( 4 )   ROMBUNNO.26PB-AM159 - 156   2015年3月

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  • 医療系学部生を対象としたJefferson Scale of Empathy Health Profession Students version(JSE-HPS)日本語版の妥当性・信頼性の検討

    藤井 里可, 小山 敏広, 四宮 一昭, 千堂 年昭, 北村 佳久, 樋口 裕二, 稲垣 正俊, 片岡 仁美, 林原 千夏, 藤森 麻衣子, 内富 庸介

    日本薬学会年会要旨集   135年会 ( 4 )   243 - 243   2015年3月

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  • がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究 薬剤師に必要なコミュニケーションに関する研究

    稲垣正俊, 樋口裕二, 千堂年昭, 北村佳久, 小山敏広, 片岡仁美, 林原千夏, 藤森麻衣子

    がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究 平成26年度 総括・分担研究報告書   27‐28   2015年

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  • がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究 がん医療者に望まれる行動に関する研究

    内富庸介, 藤森麻衣子, 梅澤志乃, 冨川由紀, 稲垣正俊, 樋口裕二, 藤原雅樹, 林原千夏, 北村佳久, 小山敏広, 長坂剛夫

    がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究 平成26年度 総括・分担研究報告書   11‐13   2015年

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  • 薬物療法の実践に重点を置いた薬学生向け救命実務実習の評価

    座間味義人, 相良英憲, 今井徹, 原直己, 武本あかね, 小山敏広, 名和秀起, 北村佳久, 氏家 良人, 千堂 年昭

    日本注射薬臨床情報学会雑誌   4   11 - 21   2015年

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  • 27-O3PM-04 救急外来における初療への薬学的介入を志向した薬学生向け救命実技演習の開発(薬剤師外来,優秀演題候補セッション5,新時代を拓く医療薬学フロンティア)

    座間味 義人, 相良 英憲, 今井 徹, 原 直己, 小山 敏広, 武本 あかね, 北村 佳久, 千堂 年昭, 名倉 弘哲

    日本医療薬学会年会講演要旨集   24   2014年8月

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    記述言語:日本語   出版者・発行元:日本医療薬学会  

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  • 粉砕法による経管投与における薬剤量損失に対する簡易懸濁法の有用性についての検討

    座間味 義人, 小山 敏広, 合葉 哲也, 天野 学, 安藤 哲信, 倉田 なおみ, 名和 秀起, 名倉 弘哲, 北村 佳久, 千堂 年昭

    静脈経腸栄養   29 ( 4 )   1027 - 1033   2014年7月

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    記述言語:日本語   出版者・発行元:(株)ジェフコーポレーション  

    【目的】従来の薬剤経管投与法である粉砕法は薬効の減少につながる薬剤量の損失が指摘されている。そこで粉砕法による薬剤量損失に対する簡易懸濁法の有用性について検討した。【方法】頻繁に粉砕指示がなされる5種類の薬剤を用いて粉砕・分包による薬物含量減少、薬剤調製時の懸濁性および実際の経管投与を想定した薬物含量について2つの方法を比較した。【結果】薬剤を粉砕・分包するとそれぞれの薬物含量は減少した。またワーファリン錠を粉砕して水に溶解すると完全には懸濁せず、小さな塊が生じたが、簡易懸濁法では均一に懸濁した。ワーファリン錠の経管投与を想定した実験において粉砕法では薬物含量が大幅に減少したが、簡易懸濁法では、ほとんど損失が認められなかった。【結論】簡易懸濁法は粉砕法に比べて薬剤損失の面で有用性が高いことが示唆され、ワーファリン錠のように安定性が悪い薬剤では特に適正な薬物投与に貢献出来ると考えられる。(著者抄録)

    DOI: 10.11244/jjspen.29.1027

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  • 薬物療法の実践に重点を置いたシミュレーション教育の有用性について

    座間味義人, 小山敏広, 白石奈緒子, 武本あかね, 四宮一昭, 万代康弘, 狩野光伸, 千堂年昭, 須野学

    日本薬学会年会要旨集(CD-ROM)   134th   ROMBUNNO.30AMS-001   2014年

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  • 患者のジェネリック医薬品変更希望に影響を及ぼす患者背景・重要因子の探索―ジェネリック医薬品の適切な使用促進のために―

    四宮一昭, 池方康一郎, 小山敏広, 山本和宏, 平野剛, 北村佳久, 平井みどり, 千堂年昭

    日本薬剤師会雑誌   65 ( 11 )   1323 - 1325   2013年11月

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  • 薬剤師職能の拡大への取り組みに関する基礎的研究~「薬剤師外来」設置が糖尿病の改善に与える影響~

    北村佳久, 千堂年昭, 大西順子, 小山敏広, 尾上由華, 鍬塚圭子, 三宅昭代, 三宅彩香, 中村紘子, 米田沙緒里

    医療の広場   53 ( 4 )   12 - 16   2013年4月

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  • ラットの行動変化から推察する抗がん剤投与による精神機能変化―ドキソルビシンおよびシクロホスファミド投与による影響―

    北村佳久, 服部紗代, 米田沙緒里, 三宅彩香, 小山敏広, 宮崎育子, 浅沼幹人, 千堂年昭

    日本サイコオンコロジー学会総会プログラム・抄録集   26th   132   2013年

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  • 抗がん剤投与患者に対する中枢神経系作用薬の処方に関する調査

    山下佳晃, 北村佳久, 小山敏広, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   133rd   ROMBUNNO.30AMF-559   2013年

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  • 術後せん妄早期発見ツールの探索を目指した危険因子・予測因子の調査

    渡邊沙織, 北村佳久, 村川公央, 小山敏広, 千堂年昭

    日本薬学会年会要旨集(CD-ROM)   133rd   ROMBUNNO.30AMF-533   2013年

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  • 血液透析患者の貧血管理―病院薬剤師による積極的介入の2.5年後評価―

    大西順子, 林雄一郎, 李美淑, 尾上由華, 鍬塚圭子, 三宅昭代, 小山敏広, 川崎博己, 北村佳久

    日本病院薬剤師会雑誌   48 ( 5 )   599 - 603   2012年5月

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  • 病院薬剤師の新たな業務展開としての「糖尿病薬剤師外来」の有用性についての検討―臨床検査値からの検討―

    米田紗緒里, 大西順子, 中村紘子, 李美淑, 黒田真生, 小山敏広, 川崎博己, 名倉弘哲, 北村佳久

    日本医療薬学会年会講演要旨集   21st   304   2011年9月

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  • P-0589 経腸栄養剤を用いた疎水性薬剤の簡易懸濁法適用の検討(一般演題 ポスター発表,医薬品情報・データベース,Enjoy Pharmacists' Lifestyles)

    座間味 義人, 松永 康臣, 合葉 哲也, 天野 学, 小山 敏広, 四宮 一昭, 北村 佳久, 黒崎 勇二, 佐々木 健二, 野田 真吾, 千堂 年昭, 川崎 博己, 五味田 裕

    日本医療薬学会年会講演要旨集   21   2011年9月

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    記述言語:日本語   出版者・発行元:日本医療薬学会  

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  • 病院薬剤師の新たな業務展開としての「糖尿病薬剤師外来」の有用性についての検討―アンケート調査からの検討―

    中村紘子, 大西順子, 米田紗緒里, 李美淑, 黒田真生, 小山敏広, 川崎博己, 名倉弘哲, 北村佳久

    日本医療薬学会年会講演要旨集   21st   304   2011年9月

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  • Paracrine control of mesenteric perivascular axo-axonal interaction

    H. Kawasaki, S. Takatori, Y. Zamami, T. Koyama, M. Goda, K. Hirai, P. Tangsucharit, X. Jin, N. Hobara, Y. Kitamura

    Acta Physiologica   203 ( 1 )   3 - 11   2011年9月

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    掲載種別:書評論文,書評,文献紹介等  

    Immunohistochemical study of rat mesenteric arteries showed dense innervation of adrenergic nerves, calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves), nitric oxide-containing nerves (nitrergic nerves). Double-immunostaining revealed that most CGRPergic or nitrergic nerves were in close contact with adrenergic nerves. CGRPergic and transient receptor potential vanilloid-1 (TRPV1)-immunopositive nerves appeared in the same neurone. In rat perfused mesenteric vascular beds without endothelium and with active tone, perfusion of nicotine, or bolus injection of capsaicin and acetylcholine and periarterial nerve stimulation (PNS) lowered pH levels of out flowed perfusate concomitant with vasodilation. Cold-storage denervation of preparations abolished pH lowering induced by nicotine and PNS. Guanethidine inhibited PNS- and nicotine-, but not acetylcholine- and capsaicin-, induced pH lowering. Pharmacological analysis showed that protons were released not only from adrenergic nerves but also from CGRPergic nerves. A study using a fluorescent pH indicator demonstrated that nicotine, acetylcholine and capsaicin applied outside small mesenteric artery lowered perivascular pH levels, which were not observed in Ca 2+ free medium. Exogenously injected hydrochloric acid in denuded preparations induced pH lowering and vasodilation, which was inhibited by denervation, TRPV1 antagonists and capsaicin without affecting pH lowering. These results suggest that excitement of adrenergic nerves releases protons to activate TRPV1 in CGRPergic nerves and thereby induce vasodilation. It is also suggested that CGRPergic nerves release protons with exocytosis to facilitate neurotransmission via a positive feedback mechanism. © 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society.

    DOI: 10.1111/j.1748-1716.2010.02197.x

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  • ACTH反復投与ラットにおける海馬細胞新生の減少およびそのメカニズムに関する検討

    林宏美, 土居真穂, 尾上由華, 鍬塚圭子, 三宅彩香, 小山敏広, 四宮一昭, 宮崎育子, 浅沼幹人, 北村佳久

    日本薬学会年会要旨集   131st ( 1 )   257   2011年3月

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  • 疎水性薬剤に対する経腸栄養剤を用いた簡易懸濁法適用の検討

    松永 康臣, 座間味 義人, 大西 順子, 小山 敏広, 四宮 一昭, 高取 真吾, 北村 佳久, 佐々木 健二, 川崎 博己, 野田 真吾

    日本薬学会年会要旨集   131年会 ( 4 )   258 - 258   2011年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • The different effects of histamine H1 receptor antagonists on histamine-induced vasodilation in rat mesenteric arteries

    Yukimi Narahara, Sayo Hatutori, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Shingo Takatori, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   115   210P - 210P   2011年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in ACTH treated rats

    Hiromi Hayashi, Maho Doi, Yuka Onoue, Keiko Kuwatsuka, Ayaka Miyake, Toshihiro Koyama, Kazuaki Shinomiya, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura

    JOURNAL OF PHARMACOLOGICAL SCIENCES   115   251P - 251P   2011年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • 血液透析患者における腎性貧血治療に対する薬剤師の関与の影響

    三宅昭代, 大西順子, 尾上由華, 鍬塚圭子, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

    日本医療薬学会年会講演要旨集   20th   397   2010年10月

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    記述言語:日本語  

    J-GLOBAL

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  • P1-376 薬剤師および他職種を対象とした院内抗がん剤調製マニュアルの作成と評価(一般演題 ポスター発表,癌薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

    林 宏美, 名和 秀起, 岡田 健男, 川上 英治, 晴田 佑介, 杉本 志保, 小山 敏広, 四宮 一昭, 松永 尚, 北村 佳久, 千堂 年昭

    日本医療薬学会年会講演要旨集   20   2010年10月

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    出版者・発行元:日本医療薬学会  

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  • 血液透析患者における血清intact‐PTH値管理に対する薬剤師関与の影響~活性型ビタミンD静注製剤パルス療法施行中の症例に着目して~

    尾上由華, 大西順子, 鍬塚圭子, 三宅昭代, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

    日本医療薬学会年会講演要旨集   20th   397   2010年10月

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    記述言語:日本語  

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  • 血液透析患者における血清リン・カルシウム値管理の適正化を目指した薬剤師の取り組み

    鍬塚圭子, 大西順子, 尾上由華, 三宅昭代, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

    日本医療薬学会年会講演要旨集   20th   397   2010年10月

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    記述言語:日本語  

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  • ラット腸間膜動脈におけるヒスタミン誘発血管弛緩反応に及ぼす塩酸レボカバスチンおよび塩酸オロパタジンの影響

    小山敏広, 楢原由生未, 孫鵬遠, 李思敏, 金しん, 座間味義人, 高取慎吾, 北村佳久, 川崎博已

    アレルギー・免疫   17 ( 4 )   662 - 670   2010年3月

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    記述言語:日本語   出版者・発行元:(株)医薬ジャーナル社  

    ヒスタミン誘発血管弛緩反応に対するヒスタミンH1受容体拮抗薬レボカバスチンとオロパタジンの効果についてラット腸間膜動脈灌流標本を用いて比較検討した。灌流圧を上昇させた標本において、ヒスタミン(10^-8-10^-4M)による濃度依存性の血管弛緩反応は、レボカバスチン(10μM)およびオロパタジン(10μM)によって抑制されたが、レボカバスチンの抑制率がオロパタジンの抑制率に比較して有意に大であった。H2およびH3受容体拮抗薬が共存するとオロパタジンの抑制作用はレボカバスチンの作用と同程度となった。これらの結果から、レボカバスチンはオロパタジンに比べて、強いH2、H3受容体への拮抗作用を有することが拮抗作用の要因と考えられる。(著者抄録)

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  • Characterization and age-related changes in endothelial modulation of vasoconstriction in resistance artery

    Xin Jin, Yukiko Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   18P - 18P   2010年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Proton as a Possible Neurotransmitter for Perivascular Axo-axonal Transmission in the Rat Mesenteric Resistance Artery

    Hiromu Kawasaki, Satoko Miyashita, Yoshito Zamami, Toshihiro Koyama, Mitsunobu Goda, Xin Jin, Yukiko Iwatani

    Tzu Chi Medical Journal   21 ( 2 )   95 - 98   2009年6月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    The rat mesenteric resistance arteries are densely innervated by adrenergic vasoconstrictor nerves, CGRPergic vasodilator nerves and nitric oxide-containing nerves. Those nerves have axo-axonal interactions to modulate vascular nerve function and to regulate vascular tone. The present study focused on a possible transmitter, which is involved in axo-axonal transmission of adrenergic nerves and CGRP nerves. When nicotine is applied in the rat perfused mesenteric artery, nicotine stimulates nicotinic α3β4 nicotinic acetylcholine receptors on adrenergic nerves. This stimulation leads to the release of proton from adrenergic nerves. Released proton activates transient receptor potential vanilloid-1 receptors on neighboring CGRP nerves and CGRP is released to cause vasodilation. The present findings would explain why CGRPergic nerves, which are capsaicin-sensitive sensory nerves, have efferent function in spite of being primary afferent nerves. Namely, efferent adrenergic nerves, which momentarily and constantly regulate the vascular tone, may send their information to the neighboring CGRPergic nerves. Proton may be used as the transmitter for axo-axonal transmission to counteract excess vasoconstriction as the efferent function of afferent sensory nerves. Recent study demonstrated that periarterial nerve stimulation of perfused mesenteric arteries resulted in a decrease in the pH level of the perfusate concomitant with CGRPergic nerve-mediated vasodilation, which was abolished by the adrenergic neuron blocker, guanethidine. These findings suggest that proton acts as a transmitter for axo-axonal transmission between adrenergic and CGRPergic nerves in mesenteric resistance arteries. In conclusion, the present study presents evidence that perivascular nerves have strong axo-axonal interaction to modulate nerve function and to regulate vascular tone. © 2009 Buddhist Compassion Relief Tzu Chi Foundation.

    DOI: 10.1016/S1016-3190(09)60018-5

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  • 腸間膜動脈抵抗血管の内皮細胞による血管緊張調節の特性

    金シン, 音無由紀子, 座間味義人, 小山敏広, 孫鵬遠, 川村直美, 坪井崇, 山口康代, 上田太郎, 北村佳久, 川崎博己

    日本薬学会年会要旨集   129th ( 1 )   260   2009年3月

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    記述言語:日本語  

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  • 2‐Kidney,1‐Clip(2K‐1C)高血圧ラット腸間膜動脈の血管周囲交感神経亢進におけるAngiotensin受容体の関与

    小山敏広, 畑中由香子, 芳原成美, 合田光寛, 座間味義人, 北村佳久, 川崎博已

    血管   32 ( 1 )   22   2009年1月

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    記述言語:日本語  

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  • INHIBITORY EFFECT OF VASCULAR ENDOTHELIUM ON AGONIST-INDUCED VASOCONSTRICTION IN RAT MESENTERIC RESISTANCE ARTERIES DISAPPERS WITH AGEING

    Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Toshihiro Koyama, Peng Yuan Sun, Narumi Hobara, Yoshihisa Kitamura, Hiromu Kawasaki

    JOURNAL OF VASCULAR RESEARCH   46   108 - 108   2009年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:KARGER  

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  • 食後高血糖下における神経性血管調節の変化とレドックスの関与 (生体機能と創薬シンポジウム2008--生命システムにおける情報ネットワークの重要性を解く 講演要旨集) -- (シンポジウム 呼吸器および循環器系疾患とレドックス制御)

    座間味 義人, 高取 真吾, 岩谷 有希子

    薬学雑誌   128 ( 0 )   70 - 72   2008年9月

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    記述言語:日本語   出版者・発行元:日本薬学会  

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  • 食後高血糖下における神経性血管調節の変化とレドックスの関与

    座間味義人, 高取真吾, 岩谷有希子, JIN Xin, 小山敏広, 北村佳久, 川崎博己

    生体機能と創薬シンポジウム要旨集   2008   70 - 72   2008年9月

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  • Vascular nitric oxide (NO)containing nerves are decreased in regulation of adrenergic neurotransmission in mesenteric resistance arteries of early phase of 2-kidey 1-clip hypertensive rats

    Toshihiro Koyama, Chiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   106   218P - 218P   2008年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • フルクトース負荷インスリン抵抗性モデル(ラット)におけるPropolisによるインスリン抵抗性改善作用

    座間味 義人, 高取 真吾, 小山 敏広, 合田 光寛, 岩谷 有希子, 土井 志真, 川崎 博己

    薬学雑誌   127 ( 12 )   2065 - 2073   2007年12月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

    インスリン抵抗性モデルラットであるフルクトース飲料水負荷ラット(FDR)を用いて、propolisを長期間経口投与し、propolisのインスリン抵抗性に及ぼす影響について検討した。また、腸間膜動脈床を用いて、FDRにおける血管反応性及び血管周囲神経機能変化に及ぼすpropolisの影響についても検討した。体重、血清中インスリン値及びインスリン抵抗性指数HOMA-R値は有意に低下し、血圧はpropolisの高用量で低下傾向を示した。腸間膜動脈灌流標本を用いての腸間膜動脈に分布する血管周囲神経機能に対しての検討から、propolisはFDRにおけるインスリン抵抗性の進行に伴う交感神経機能の亢進及びCGRP神経機能の減弱を改善した。propolisはインスリン抵抗性を改善する作用を持つ可能性が示唆された。

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  • フルクトース負荷早期における血管反応性の変化

    薮前 奈々, 細田 美穂, 座間味 義人, 金 きょう, 合田 光寛, 小山 敏広, 高取 真吾, 高山 房子, 川崎 博己

    日本薬理学雑誌   130 ( 3 )   12P - 12P   2007年9月

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    記述言語:日本語   出版者・発行元:(公社)日本薬理学会  

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  • フルクトース負荷ラットのインスリン抵抗性に及ぼすプロポリス長期投与の影響

    小山 敏広, 土井 志真, 高取 真吾, 座間味 義人, 合田 光寛, 高山 房子, 見尾 光庸, 川崎 博己

    日本薬学会年会要旨集   127年会 ( 2 )   133 - 133   2007年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • Vascular tone regulation of calcitonin gene-related peptide (CGRP)and nitric oxide (NO)-containing nerves in mesenteric resistance arteries of hypertensive rats.

    Toshihiro Koyama, Tiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   103   145P - 145P   2007年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Vascular nitric oxide (NO)-containing nerves regulate adrenergic neurotransmission in mesenteric resistance arteries of hypertensive rat.

    Toshihiro Koyama, Chiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   103   70P - 70P   2007年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Telithromycin inhibits vascular adrenergic neurotransmission in rat mesenteric artery

    Yukako Hatanaka, Toshihiro Koyama, Narumi Hobara, Fusako Takayama, Hiromu Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   103   144P - 144P   2007年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Neuronal nitric oxide inhibits the neurogenic norepinephrine release in rat mesenteric resistance arteries

    Y Hatanaka, N Hobara, HH Jin, T Koyama, S Akiyama, F Takayama, H Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   100   282P - 282P   2006年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • Histamine induces constriction and relaxation mediated by perivascular nerves in rat mesenteric resistance arteries without endothelium

    H Jin, T Koyama, Y Hatanaka, F Takayama, H Kawasaki

    JOURNAL OF PHARMACOLOGICAL SCIENCES   97   72P - 72P   2005年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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共同研究・競争的資金等の研究

  • 【研究分担】シナジー効果探索手法の構築と医療情報データベースへの適用

    研究課題/領域番号:20H05798  2020年10月 - 2023年03月

    日本学術振興会  科学研究費助成事業 学術変革領域研究(B)  学術変革領域研究(B)

    座間味 義人, 中馬 真幸, 小山敏広, 石澤 有紀, 石澤 啓介

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    担当区分:研究分担者 

    配分額:41600000円 ( 直接経費:32000000円 、 間接経費:9600000円 )

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  • 【研究代表】外来診療における小児の急性上気道感染症および急性下痢症への抗生剤処方に及ぼす医療政策の影響についての疫学研究

    2019年11月 - 2020年06月

    ヘルスケア・データサイエンス研究所 

    小山 敏広, 萩谷英大, 座間味義人, 狩野光伸

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    担当区分:研究代表者  資金種別:競争的資金

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  • 【研究代表】医療ビッグデータの活用による高齢者医療の疾病構造と質評価に関する臨床疫学研究

    2019年04月 - 2022年03月

    文部科学省  科研費(基盤C) 

    小山 敏広, 萩谷英大, 座間味義人, 狩野光伸, 樋之津史郎

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    担当区分:研究代表者  資金種別:競争的資金

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  • 【研究代表】保健関連SDGsの達成に向けたビッグデータ・オープンデータの活用法の開発

    2018年10月 - 2019年01月

    文部科学省  研究大学強化促進事業 

    小山 敏広, 狩野光伸, 千堂年昭, 近藤豊, 座間味義人, 北村義久, 萩谷英大, 白石奈保子, 建部泰久, 港 雄介

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    担当区分:研究代表者  資金種別:競争的資金

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  • 【研究代表】生活習慣病合併型心房細動における新規抗凝固療法の評価系の構築

    2016年04月 - 2019年03月

    文部科学省  科研費(若手B) 

    小山 敏広

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    担当区分:研究代表者  資金種別:競争的資金

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  • 【研究分担】我が国初のメガホスピタルネットワーク実施調査:隠された各地域圏医療ニーズ・産業シーズの“見える化”: 我が国の未来を拓く地域の実現に関する調査研究

    2014年11月 - 2015年03月

    科学技術振興機構(JST) 

    森田 潔, 狩野光伸, 佐藤法仁, 小山敏広

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    担当区分:研究分担者 

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  • 【研究分担】神経細胞新生を基盤とした治療抵抗性うつ病の病態解明および治療薬開発

    研究課題/領域番号:21590593  2009年04月 - 2012年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    北村 佳久, 川崎 博己, 浅沼 幹人, 小山 敏広

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    担当区分:連携研究者 

    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    治療抵抗性うつ病の病態メカニズムの解明のために、下垂体ホルモンであるACTHを反復投与した治療抵抗性うつ病の動物モデルラットを用いて検討を行った。その結果、ドパミン神経作用薬が有効であることを明らかにした。本作用には側坐核におけるドパミン神経機能の亢進が考えられた。また、本モデルでは海馬における細胞新生は抑制されることを見出した。さらに、この抑制作用はimipramineとlithiumの併用投与、電気けいれん療法により拮抗した。以上の結果より、治療抵抗性うつ病の病態には細胞新生の抑制が考えられ、その改善には細胞新生の改善が必要であることを明らかにした。

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担当授業科目

  • ヒトをみる (2021年度) 第3学期  - 月1~2

  • 早期体験学習A (2021年度) 第1学期  - 金5~8

  • 臨床治療学概論 (2021年度) 1・2学期  - [第1学期]木1~2, [第2学期]木1,木2

  • 臨床準備教育II (2021年度) 1・2学期  - 月3~4

  • 臨床準備教育III (2021年度) 特別  - その他

  • 薬物治療学1 (2021年度) 第1学期  - 水1~2

  • 薬物治療学2 (2021年度) 第2学期  - 水1~2

  • 薬物治療学3 (2021年度) 第1学期  - 水3~4

  • 薬物治療学4 (2021年度) 第2学期  - 水3~4

  • ヒトをみる (2020年度) 第3学期  - 月1,月2

  • 早期体験学習I (2020年度) 第1学期  - 金5,金6,金7,金8

  • 臨床治療学概論 (2020年度) 1・2学期  - 木1,木2

  • 臨床準備教育III (2020年度) 特別  - その他

  • 薬物治療学1 (2020年度) 第1学期  - 水1,水2

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  • 薬物治療学3 (2020年度) 第1学期  - 水3,水4

  • 薬物治療学4 (2020年度) 第2学期  - 水3,水4

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▼全件表示