Faculty Profiles - KOYAMA Toshihiro

写真a

KOYAMA Toshihiro

Organization

Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor

Contact information

External link

Degree

PhD ( 2010.3 )

Research Interests

Health care big data
Geriatrics and Gerontology
Infectious Diseases
Health Policy
Clinical Epidemiology
薬剤疫学
Healthcare Education

Research Areas

Life Science / Medical management and medical sociology

Professional Memberships

日本薬学会

2005.4

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日本計量生物学会

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Committee Memberships

岡山大学教育改革設計委員会

2022.4 - 2023.3

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Committee type：Other
岡山大学教育改革構想委員会

2021.4 - 2022.3

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Committee type：Other

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Papers

Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries Reviewed International coauthorship International journal

Ko Harada, Quynh Thi Vu, Yoshito Nishimura, Tatsuaki Takeda, Hirofumi Hamano, Yusuke Minato, Yoshito Zamami, Toshihiro Koyama, Hideharu Hagiya

International Journal of Infectious Diseases 158 107932 - 107932 2025.9

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.ijid.2025.107932

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Global trends in idiopathic pulmonary fibrosis mortality rates during 2001–2022 Reviewed International coauthorship International journal

Ko Harada, Yoshito Nishimura, Quynh Thi Vu, Maki Yamamoto, Toshihiro Koyama, Hideharu Hagiya

ERJ Open Research 00362 - 2025 2025.6

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Language：English Publishing type：Research paper (scientific journal) Publisher：European Respiratory Society (ERS)

Background

Idiopathic pulmonary fibrosis is a chronic, progressive, and ultimately fatal lung disease. Updated global mortality data, especially from underexplored countries, are limited. This study aimed to understand the current global trends in idiopathic pulmonary fibrosis-associated mortality rates.

Methods

This observational study used the World Health Organization Mortality Database to analyse data stratified by sex, age, and geographic region, encompassing 64 countries between 2001 and 2022. Idiopathic pulmonary fibrosis was defined according to the International Code for Diseases-10 code J84.1. Crude and age-standardised mortality rates per 100 000 individuals were calculated to estimate long-term mortality trends. Mortality rates were calculated by dividing idiopathic pulmonary fibrosis-associated deaths by the corresponding population, with age-specific rates determined for each 5-year age-group. Trends in the 2001–2022 period were analysed using a locally weighted regression model, and the average annual percentage change in mortality rates between 2010 and 2022 was estimated using joinpoint regression analysis.

Results

Overall, 874 998 deaths associated with idiopathic pulmonary fibrosis were analysed. The LOESS-smoothed crude mortality rate increased from 2.10 (95% confidence interval [CI]: 1.77–2.43) per 100 000 in 2001 to 3.14 (95% CI: 2.71–3.57) per 100 000 by 2022. The LOESS-smoothed age-standardised mortality rates increased overall, peaking at 1.59 (95% CI: 1.51–1.67) per 100 000 in 2018 and declining slightly to 1.57 (95% CI: 1.35–1.79) per 100 000 in 2022. Mortality was higher among males than females; furthermore, 87.5% of deaths occurred in individuals aged ≥65 years. Mortality rates were highest among the American population, with a notable increase in Latin American countries.

Conclusion

Idiopathic pulmonary fibrosis-associated mortality rates have increased globally, particularly in males. Significant geographical, age, and sex disparities were observed, emphasising the need for targeted public-health measures and improved disease management.

DOI： 10.1183/23120541.00362-2025

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International trends in biliary tract cancer-related mortality, 2000-2022: An observational study of the World Health Organization mortality database. Reviewed International coauthorship International journal

Quynh Thi Vu, Yoshito Nishimura, Ko Harada, Hiroki Ito, Tsukasa Higashionna, Akinari Maruo, Keisaku Harada, Tatsuaki Takeda, Hirofumi Hamano, Yoshito Zamami, Hideharu Hagiya, Toshihiro Koyama

Hepatology (Baltimore, Md.) 2024.12

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AIMS: Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), gallbladder cancer (GBC), and ampullary cancer, exhibit poor prognosis. This study examined temporal trends in mortality due to BTCs and their major subtypes at international, regional, and national levels. APPROACH RESULTS: This observational study used the World Health Organization mortality database. Locally weighted regression (LOESS) was used to produce a smoothed curve of long-term international and regional BTC and major subtype-related mortality rates in 2000-2022 based on available data from countries. Trends in age-standardised mortality rates (ASRs) during 2013-2022 for individual countries were examined using joinpoint regression analysis. Internationally, LOESS-smoothed ASRs per 100,000 population due to BTCs were 2.8 (95% confidence interval: 2.5-3.1) in 2000, and 2.7 (2.3-3.1) in 2022. LOESS-smoothed BTC-related ASRs were the highest in the Western Pacific region at 4.2 (1.8-6.6) in 2022, compared with those in the European and American regions at 2.6 (2.3-2.9) and 2.2 (1.8-2.6), respectively. Among major subtypes, LOESS-smoothed ASRs due to iCCA increased by 120.0%, those due to GBC decreased by 45.5%, and those due to eCCA remained stable between 2000 and 2022. Disparities in BTC and major subtype-related ASR trends were observed between countries during 2013-2022, with iCCA-associated ASRs showing increasing trends in many countries. CONCLUSIONS: Although internationally estimated BTC-associated ASRs showed a stable trend over the last two decades, a large increase in estimated iCCA-associated ASRs necessitates developing effective screening for high-risk individuals and disease management strategies.

DOI： 10.1097/HEP.0000000000001200

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Burden of depressive disorders in Vietnam from 1990 to 2019: A secondary analysis of the Global Burden of Disease Study 2019. Reviewed International coauthorship International journal

Quynh Thi Vu, Ko Harada, Yoshito Nishimura, Hideharu Hagiya, Elizabeth Tan, Odifentse Mapula E Lehasa, Yoshito Zamami, Toshihiro Koyama

Journal of psychiatric research 172 420 - 426 2024.4

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Depressive disorders are among the leading causes of disability globally. However, information on the burden of depressive disorders in Vietnam is limited. We aimed to analyse the burden of depressive disorders in Vietnam from 1990 to 2019. Using data from the Global Burden of Disease Study 2019, prevalence and disability-adjusted life-years (DALYs) were used as indicators to analyse the burden of depressive disorders by age and sex. In 2019 in Vietnam, depressive disorders comprised 2629.1 thousand (95% uncertainty interval (UI): 2233.3-3155.9) estimated cases and 380.6 thousand (95% UI: 258.9-533.8) estimated DALYs. The crude prevalence rate of depressive disorders was higher among females than among males. The DALYs of depressive disorder accounted for a higher percentage of the total all-cause DALYs in the 10-64-year age group than in other age groups. Major depressive disorder was the largest contributor to the burden of depressive disorders. From 1990 to 2019, the crude prevalence and DALY rates per 100 000 population due to depressive disorders increased significantly, whereas age-standardised rates of prevalence and DALYs decreased significantly; the respective average annual percent changes were 0.88% (95% confidence interval: 0.87 to 0.89), 0.68% (0.66 to 0.70), -0.20% (-0.21 to -0.19), and -0.27% (-0.28 to -0.25). Although the age-standardised prevalence rate was lower than that seen globally, depressive disorders were considerable mental health issues in Vietnam. This study will help governments and policymakers to establish appropriate strategies to reduce the burden of these disorders by identifying the priority areas and individuals.

DOI： 10.1016/j.jpsychires.2024.02.041

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International Trends in Adverse Drug Event-Related Mortality from 2001 to 2019: An Analysis of the World Health Organization Mortality Database from 54 Countries. Reviewed International coauthorship International journal

Koyama T, Iinuma S, Yamamoto M, Niimura T, Osaki Y, Nishimura S, Harada K, Zamami Y, Hideharu Hagiya

Drug safety 2023.12

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<h4>Background and objective</h4>Adverse drug events (ADEs) are becoming a significant public health issue. However, reports on ADE-related mortality are limited to national-level evaluations. Therefore, we aimed to reveal overall trends in ADE-related mortality across the 21st century on an international level.<h4>Methods</h4>This observational study analysed long-term trends in ADE-related mortality rates from 2001 to 2019 using the World Health Organization Mortality Database. The rates were analysed according to sex, age and region. North America, Latin America and the Caribbean, Western Europe, Eastern Europe and Western Pacific regions were assessed. Fifty-four countries were included with four-character International Statistical Classification of Disease and Related Health Problems, Tenth Revision codes in the database, population data in the World Population Prospects 2019 report, mortality data in more than half of the study period, and high-quality or medium-quality death registration data. A locally weighted regression curve was used to show international trends in age-standardised rates.<h4>Results</h4>The global ADE-related mortality rate per 100,000 population increased from 2.05 (95% confidence interval 0.92-3.18) in 2001 to 6.86 (95% confidence interval 5.76-7.95) in 2019. Mortality rates were higher among men than among women, especially in those aged 20-50 years. The population aged ≥ 75 years had higher ADE-related mortality rates than the younger population. North America had the highest mortality rate among the five regions. The global ADE-related mortality rate increased by approximately 3.3-fold from 2001 to 2019.<h4>Conclusions</h4>The burden of ADEs has increased internationally with rising mortality rates. Establishing pharmacovigilance systems can facilitate efforts to reduce ADE-related mortality rates globally.

DOI： 10.1007/s40264-023-01387-0

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Trends in Head and Neck Cancer Mortality from 1999 to 2019 in Japan: An Observational Analysis. Reviewed International coauthorship International journal

Tsukasa Higashionna, Keisaku Harada, Akinari Maruo, Takahiro Niimura, Elizabeth Tan, Quynh Thi Vu, Takayoshi Kawabata, Soichiro Ushio, Hirofumi Hamano, Makoto Kajizono, Yoshito Zamami, Keisuke Ishizawa, Ko Harada, Shiro Hinotsu, Mitsunobu R Kano, Hideharu Hagiya, Toshihiro Koyama

Cancers 15 ( 15 ) 2023.7

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Globally, the numbers of head and neck cancer (HNC) cases and related deaths have recently increased. In Japan, few studies have examined crude or age-adjusted HNC mortality rates. Therefore, this study aimed to determine the trends in crude and age-adjusted mortality rates for HNC per million individuals in Japan from 1999 to 2019. Data on HNC-associated deaths were extracted from the national death certificate database using the International Classification of Diseases, Tenth Revision (n = 156,742). HNC mortality trends were analysed using joinpoint regression models to estimate annual percentage change (APC) and average APC (AAPC). Among men, no significant change was observed in the age-adjusted death rate trend from 1999 to 2014; however, a marked decrease was observed from 2014 to 2019. No changing point was observed in women. Age-adjusted mortality rates continuously decreased over the 21-year period, with an AAPC of -0.7% in men and -0.6% in women. In conclusion, the overall trend in age-adjusted rates of HNC-associated deaths decreased, particularly among men, in the past 5 years. These results will contribute to the formulation of medical policies to develop targeted screening and prevention programmes for HNC in Japan and determine the direction of treatment strategies.

DOI： 10.3390/cancers15153786

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Global trends of seasonal influenza-associated mortality in 2001-2018: A longitudinal epidemiological study. Reviewed International coauthorship International journal

Hideharu Hagiya, Yuka Osaki, Michio Yamamoto, Takahiro Niimura, Ko Harada, Tsukasa Higashionna, Hirofumi Hamano, Yoshito Zamami, Shiro Hinotsu, Toshihiro Koyama

The Journal of infection 87 ( 3 ) e54-e57 2023.6

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DOI： 10.1016/j.jinf.2023.06.011

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Association between immune checkpoint inhibitor-induced myocarditis and concomitant use of thiazide diuretics. Reviewed International journal

Satoru Mitsuboshi, Hirofumi Hamano, Takahiro Niimura, Aya F Ozaki, Pranav M Patel, Tsung-Jen Lin, Yuta Tanaka, Ikuya Kimura, Naohiro Iwata, Shoya Shiromizu, Masayuki Chuma, Toshihiro Koyama, Yoshihiro Yamanishi, Yasunari Kanda, Keisuke Ishizawa, Yoshito Zamami

International journal of cancer 153 ( 8 ) 1472 - 1476 2023.6

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Although an association has been reported between diuretics and myocarditis, it is unclear whether the risk of immune checkpoint inhibitor (ICI)-induced myocarditis is affected by concomitant diuretics. Thus, the aim of this work was to evaluate the impact of concomitant diuretics on ICI-induced myocarditis. This cross-sectional study used disproportionality analysis and a pharmacovigilance database to assess the risk of myocarditis with various diuretics in patients receiving ICIs via the analysis of data entered into the VigiBase database through December 2022. Multiple logistic regression analysis was performed to identify risk factors for myocarditis in patients who received ICIs. A total of 90 611 patients who received ICIs, including 975 cases of myocarditis, were included as the eligible dataset. A disproportionality in myocarditis was observed for loop diuretic use (reporting odds ratio 1.47, 95% confidence interval [CI] 1.02-2.04, P = .03) and thiazide use (reporting odds ratio 1.76, 95% CI 1.20-2.50, P < .01) in patients who received ICIs. The results of the multiple logistic regression analysis showed that the use of thiazides (odds ratio 1.67, 95% CI 1.15-2.34, P < .01) was associated with an increased risk of myocarditis in patients who received ICIs. Our findings may help to predict the risk of myocarditis in patients receiving ICIs.

DOI： 10.1002/ijc.34616

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Cardiovascular Toxicities Associated with Anaplastic Lymphoma Kinase Inhibitors: A Disproportionality Analysis of the WHO Pharmacovigilance Database (VigiBase). Reviewed International journal

Takahiro Niimura, Koji Miyata, Hirofumi Hamano, Yuuki Nounin, Hiroto Unten, Masaki Yoshino, Satoru Mitsuboshi, Fuka Aizawa, Kenta Yagi, Toshihiro Koyama, Mitsuhiro Goda, Yasunari Kanda, Yuki Izawa-Ishizawa, Yoshito Zamami, Keisuke Ishizawa

Drug safety 46 ( 6 ) 545 - 552 2023.6

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INTRODUCTION: Recently, cases of cardiovascular toxicities, such as pericarditis, caused by anaplastic lymphoma kinase (ALK) inhibitors have been reported; however, whether these adverse events are common among all ALK inhibitors remains unclear. AIMS: This study aimed to clarify the cardiovascular toxicity profile of ALK inhibitors using an adverse event spontaneous report database. METHODS: We analyzed data from VigiBase, the WHO global database of individual safety reports, from its inception in 1968 to December 2021. We calculated the reporting odds ratio to evaluate the association between ALK inhibitors (crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib) and 21 cardiovascular adverse events. Time to onset of pericarditis from ALK inhibitor administration was analyzed. RESULTS: Of the 27,994,584 reports, 19,911 involved treatment with ALK inhibitors. Among the 21 cardiovascular toxicities, only pericarditis signals were detected with all five ALK inhibitors (crizotinib [reporting odds ratios (ROR), 4.7; 95% CI 3.63-6.15], ceritinib [ROR, 12.9; 95% CI 9.37-17.79], alectinib [ROR, 4.8; 95% CI 3.15-7.42], brigatinib [ROR, 3.5; 95% CI 1.33-9.46], and lorlatinib [ROR, 6.4; 95% CI 3.60-11.22]). For torsade de pointes/QT prolongation, signals were detected with crizotinib (ROR, 5.0; 95% CI 3.72-6.77) and ceritinib (ROR, 4.2; 95% CI 2.17-8.05), whereas for hypertension, they were identified only with brigatinib (ROR, 3.9; 95% CI 2.88-5.20), and for heart failure, they were detected with alectinib (ROR, 2.2; 95% CI 1.60-2.90), crizotinib (ROR, 2.1; 95% CI 1.72-2.48), and lorlatinib (ROR, 2.0; 95% CI 1.27-3.23). Regarding time-to-onset analysis from drug administration to adverse event reporting, for pericarditis, it ranged from 52.5 days for alectinib to 166.5 days for crizotinib. CONCLUSIONS: Systematic evaluation of ALK inhibitor-associated adverse events revealed differences in the cardiotoxicity profiles among ALK inhibitors. Understanding the differences in the cardiovascular toxicity profile of each ALK inhibitor will contribute to safe drug therapy when switching between ALK inhibitors.

DOI： 10.1007/s40264-023-01300-9

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Characterization of Immune Checkpoint Inhibitor–Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System Reviewed International journal

Takahiro Niimura, Yoshito Zamami, Koji Miyata, Takahisa Mikami, Mizuho Asada, Keijo Fukushima, Masaki Yoshino, Satoru Mitsuboshi, Naoto Okada, Hirofumi Hamano, Takumi Sakurada, Rie Matsuoka‐Ando, Fuka Aizawa, Kenta Yagi, Mitsuhiro Goda, Masayuki Chuma, Toshihiro Koyama, Yuki Izawa‐Ishizawa, Hiroaki Yanagawa, Hiromichi Fujino, Yoshihiro Yamanishi, Keisuke Ishizawa

The Journal of Clinical Pharmacology 63 ( 4 ) 473 - 479 2022.12

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Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Myasthenia gravis (MG) is a rare but fatal adverse event of immune checkpoint inhibitors (ICIs). We assessed whether patient characteristics differed between those with ICI‐related myasthenia gravis and those with idiopathic myasthenia gravis. Reports from the US Food and Drug Administration Adverse Event Reporting System were analyzed. Multivariate analyses were conducted to evaluate the associations between age, sex, and ICI treatment and the reporting rate of myasthenia gravis. Among 5 464 099 cases between 2011 and 2019, 53 447 were treated with ICIs. Myasthenia gravis was reported more often in ICI users. Multiple logistic regression analyses showed that the reporting rate of ICI‐related myasthenia gravis did not differ significantly between men and women; however, it was higher in older people than in younger people (adjusted odds ratio, 2.4 [95%CI, 1.84–3.13]). We also investigated useful signs for the early detection of myositis and myocarditis, which are fatal when overlapping with ICI‐related myasthenia gravis. Patients with elevated serum creatine kinase or troponin levels were more likely to have concurrent myositis and myocarditis. Unlike idiopathic myasthenia gravis, there was no sex difference in the development of ICI‐related myasthenia gravis, which may be more common in older people. Considering the physiological muscle weakness that occurs in the elderly, it may be necessary to monitor ICI‐related myasthenia gravis more closely in older people.

DOI： 10.1002/jcph.2187

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcph.2187
Trends in places and causes of death among centenarians in Japan from 2006 to 2016 International coauthorship International journal

Toshihiro Koyama, Tsukasa Higashionna, Akinori Maruo, Soichiro Ushio, Yoshito Zamami, Ko Harada, Hideharu Hagiya

Geriatrics & Gerontology International 22 ( 8 ) 675 - 680 2022.6

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim

Amid the global aging, an establishment of healthcare policies for the aged population is a common issue to be addressed. However, few studies on centenarians have reported place and cause of death (PoD and CoD, respectively) as indicators of end‐of‐life care quality. This study aimed to analyze trends in PoD and CoD among centenarians in Japan.

Methods

Data from death certificates from Japanese vital statistics were analyzed; 205 513 deaths occurred among centenarians (aged ≥100 years) in Japan during the period from 2006 to 2016. PoD prevalence was calculated for each CoD. Trends in PoD prevalence were analyzed using the Joinpoint regression model. Changing points, annual percentage changes, and average annual percentage changes (AAPCs) were calculated to examine trends.

Results

The number of deaths more than doubled from 10 340 in 2006 to 26 427 in 2016. PoDs were composed of hospitals (52.7%), nursing homes (31.4%), own homes (13.6%) and others (2.2%). Dementia and old age increased rapidly as CoD. Proportions of hospital and home deaths decreased, with AAPCs of −2.3% (95% confidence interval [CI], −2.6 to −1.9) and −2.3% (95% CI, −3.2 to −1.4), respectively. Conversely, the proportion of deaths in nursing homes rapidly increased, with an AAPC of 6.8% (95% CI, 6.0–7.7).

Conclusions

The results revealed changes in PoD among centenarians in Japan. Understanding these transitions is indispensable for health policy in aging societies. Geriatr Gerontol Int 2022; 22: 675–680.

DOI： 10.1111/ggi.14416

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ggi.14416
Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data Reviewed International journal

Yoshito Zamami, Takahiro Niimura, Takehiro Kawashiri, Mitsuhiro Goda, Yutaro Naito, Keijo Fukushima, Soichiro Ushio, Fuka Aizawa, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Koji Miyata, Kenshi Takechi, Masayuki Chuma, Toshihiro Koyama, Daisuke Kobayashi, Takao Shimazoe, Hiromichi Fujino, Yuki Izawa-Ishizawa, Keisuke Ishizawa

Biomedicine & Pharmacotherapy 148 112744 - 112744 2022.4

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.biopha.2022.112744

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Trends in hepatitis C virus‐associated mortality rates in Japan, 1998–2017 Reviewed International journal

Hideharu Hagiya, Toshihiro Koyama, Matsuo Deguchi, Yusuke Minato, Satomi Miura, Tomoko Funahashi, Yusuke Teratani, Yoshito Zamami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu Kano

Journal of Gastroenterology and Hepatology 36 ( 9 ) 2486 - 2492 2021.5

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Abstract

Background and Aim

The current prevalence of hepatitis C virus infection and hepatitis C virus‐associated mortality in Japan falls short of the World Health Organization goal of viral hepatitis elimination by 2030. We aimed to evaluate the trends in hepatitis C virus‐associated mortality in Japan.

Methods

This nationwide observational study used the Japanese Vital Statistics from 1998 to 2017 and included all Japanese hepatitis C virus‐associated deaths (84 936) of adults aged ≥ 40 years. We calculated the crude and age‐standardized mortality rates per 100 000 persons by age and sex. Joinpoint regression analysis was used to identify significant changing points in trends and to estimate the annual percentage changes and the average annual percentage changes for the entire study period.

Results

The crude mortality rate per 100 000 persons (annual death number) increased from 5.5 (3548) in 1998 to 7.0 (4843) in 2005 and decreased to 4.0 (3095) in 2017. By 2017, the crude mortality rates per 100 000 persons among men and women had dropped to 3.6 and 4.3, respectively. The age‐standardized mortality rate was higher in women than in men. The average annual percentage change was −3.8% (95% confidence interval: −5.0 to −2.5). The declining trend was more rapid in men (−4.5%, 95% confidence interval: −5.3 to −3.6) than in women (−2.7%, 95% confidence interval: −3.8 to −1.6).

Conclusions

Trends in hepatitis C virus‐associated mortality rates have declined in an accelerating manner in Japan, especially among men.

DOI： 10.1111/jgh.15517

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jgh.15517
Trends in the incidence of severe fever with thrombocytopenia syndrome in Japan: an observational study from 2013 to 2022 Reviewed International journal

Shinnosuke Fukushima, Hidemasa Akazawa, Toshihiro Koyama, Hideharu Hagiya

Scientific Reports 15 ( 1 ) 20715 - 20715 2025.7

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We aimed to determine the 10-year trend in the incidence of Severe fever with thrombocytopenia syndrome (SFTS) in Japan. This retrospective observational study used a publicly available national database. Trends in the incidence of SFTS with annual percent changes (APC) were examined using Joinpoint regression analysis with stratification by patient age, season, and region. The association between disease incidence and environmental factors was investigated using Spearman's rank correlation. Between 2013 and 2022, there were 803 notified cases (397 males and 406 females) of SFTS, with 79.5% aged ≥ 65 years. The annual incidence rate increased continuously with an APC of 9.6%. The incidence peaked between May and June, with 80.8% of cases observed between May and October. The incidence was predominantly higher in western Japan, and the mean annual incidence rate was the highest in Miyazaki prefecture, with 0.89 per 100,000 people. Correlations between the SFTS incidence rates and environmental factors were observed in western Japan, with forest area (correlation coefficient, 0.80), followed by agricultural population rate (0.70). SFTS incidence is continuously increasing in Japan, especially among the elderly population. Environmental factors such as broader forest areas and increased agricultural population were possibly associated with the incidence.

DOI： 10.1038/s41598-025-07955-x

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Other Link： https://www.nature.com/articles/s41598-025-07955-x
Impact of full-time equivalent allocation on the effectiveness of antimicrobial stewardship activities: A multicenter study in Okayama, Japan International journal

Shiho Kajita, Hideharu Hagiya, Atsushi Okita, Yuto Haruki, Haruto Yamada, Yasurou Inoue, Tsukasa Higashionna, Kana Satou, Fumihiro Torigoe, Shinobu Iwamoto, Mika Yoshida, Yumiko Yamane, Hiroki Kenmotsu, Satoru Sugimura, Yutaka Fujiwara, Fusao Ikeda, Toshihiro Koyama, Chikamasa Yoshida, Shinichirou Andou, Toshimitsu Suwaki

Journal of Infection and Chemotherapy 31 ( 7 ) 102730 - 102730 2025.7

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DOI： 10.1016/j.jiac.2025.102730

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Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Reviewed International journal

Tatsuaki Takeda, Jun Matsumoto, Tomonori Sakai, Naohiro Iwata, Hirofumi Hamano, Toshihiro Koyama, Noritaka Ariyoshi, Yoshito Zamami

British journal of clinical pharmacology 2025.5

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AIMS: Pertuzumab is used in combination with trastuzumab-based therapy for HER2-positive breast cancer. However, real-world safety information on pertuzumab remains limited. This study assessed the safety of adding pertuzumab to trastuzumab-based therapy for HER2-positive breast cancer using real-world data. METHODS: VigiBase, the World Health Organization's global database of adverse events (AEs), containing reports from November 1967 to December 2023, was used. Signals for pertuzumab-associated AEs in breast cancer cases were detected using the reporting odds ratio (ROR). RESULTS: Signals of trastuzumab plus pertuzumab relative to trastuzumab alone were detected in gastrointestinal disorders (ROR: 1.45, 95% confidence interval: 1.26-1.67), including diarrhoea (3.49, 2.83-4.30); infections and infestations (1.54, 1.24-1.91); and skin and subcutaneous tissue disorders (ROR: 1.63, 1.40-1.90), including pruritus (1.96, 1.51-2.55) and rash (1.63, 1.20-2.23). Further, signals of trastuzumab plus docetaxel plus pertuzumab relative to those of trastuzumab plus docetaxel were detected in gastrointestinal disorders (1.63, 1.38-1.93), including nausea (1.72, 1.24-2.39) and vomiting (1.48, 1.01-2.17), and in nervous system disorders (1.50, 1.20-1.87), including paraesthesia (2.60, 1.33-5.08) and peripheral sensory neuropathy (5.94, 1.79-19.71). The frequency of AEs causing or prolonging hospitalization was increased with trastuzumab plus pertuzumab compared to that with trastuzumab alone (1.18, 1.00-1.38). CONCLUSIONS: AE profiles after the addition of pertuzumab to trastuzumab-based therapy were comprehensively identified. The findings in this study highlight the importance of considering these AEs when selecting pertuzumab combination therapy to ensure the safety of patients with breast cancer.

DOI： 10.1002/bcp.70094

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Effectiveness of Sensing Gloves-Applied Virtual Reality Education System on Hand Hygiene Practice: A Randomised Controlled Trial. Reviewed International journal

Mahiro Izumi, Hideharu Hagiya, Yuki Otsuka, Yoshiaki Soejima, Shinnosuke Fukushima, Mitsunobu Shibata, Satoshi Hirota, Toshihiro Koyama, Fumio Otsuka, Akio Gofuku

American journal of infection control 2024.8

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INTRODUCTION: We developed a virtual reality (VR) education system and evaluated its clinical utility for promoting hand hygiene practices. METHODS: This prospective, two-week, randomised controlled study conducted at Okayama University Hospital, Japan, from November 2023 to January 2024, involved 22 participants (18 medical students and four residents). A fully immersive 360° VR system (VIVE Pro Eye) using a head-mounted display and sensing gloves was used to develop three healthcare tasks in a virtual patient room-Environmental Cleaning, Gauze Exchange, and Urine Collection. After monitoring all participants' baseline usage data of portable hand-rubbing alcohol in the first week, we randomly assigned them into 1:1 groups (VR training and video lecture groups). The primary outcome was differences in hand-rubbed alcohol use before and after intervention. RESULTS: Before the intervention, alcohol use did not significantly differ between both groups. After the intervention, a significant increase in alcohol use was observed in the VR training group (median: 8.2 g vs. 16.2 g; p=0.019) but not in the video lecture group. CONCLUSION: Our immersive 360° VR education system enhanced hand hygiene practices. Infection prevention and control practitioners and digital technology experts must collaborate to advance the development of superior educational devices and content.

DOI： 10.1016/j.ajic.2024.08.003

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Changes in the place of death before and during the COVID-19 pandemic in Japan Reviewed International journal

Masashi Shibata, Yuki Otsuka, Hideharu Hagiya, Toshihiro Koyama, Hideyuki Kashiwagi, Fumio Otsuka

PLOS ONE 19 ( 2 ) e0299700 - e0299700 2024.2

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Background

In the global aging, the coronavirus disease 2019 (COVID-19) pandemic may have affected the place of death (PoD) in Japan, where hospital deaths have dominated for decades. We analyzed the PoD trends before and during the COVID-19 pandemic in Japan.

Methods

This nationwide observational study used vital statistics based on death certificates from Japan between 1951 and 2021. The proportion of PoD; deaths at home, hospitals, and nursing homes; and annual percentage change (APC) were estimated using joinpoint regression analysis. Analyses were stratified by age groups and causes of death.

Results

After 2019, home deaths exhibited upward trends, while hospital death turned into downward trends. By age, no significant trend change was seen in the 0–19 age group, while hospital deaths decreased in the 20–64 age group in 2019. The trend change in home death in the ≥65 age group significantly increased since 2019 with an APC of 12.3% (95% confidence interval [CI]: 9.0 to 15.7), while their hospital death trends decreased by −4.0% (95% CI: −4.9 to −3.1) in 2019−2021. By cause of death, home death due to cancer and the old age increased since 2019 with an APC of 29.3% (95% CI: 25.4 to 33.2) and 8.8% (95% CI: 5.5 to 12.2), respectively.

Conclusion

PoD has shifted from hospital to home during the COVID-19 pandemic in Japan. The majority of whom were older population with cancer or old age.

DOI： 10.1371/journal.pone.0299700

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Trends in the Incidence of Disseminated Cryptococcosis in Japan: A Nationwide Observational Study, 2015-2021. Reviewed International journal

Hidemasa Akazawa, Hagiya H, Koyama T, Otsuka F

Mycopathologia 2024.1

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<h4>Background</h4>Cryptococcus species can cause severe disseminated infections in immunocompromised hosts. This study investigated the epidemiological features and trends in disseminated cryptococcosis in Japan.<h4>Methods</h4>We used publicly available Infectious Diseases Weekly Reports to obtain data on the incidence of disseminated cryptococcosis in Japan from 2015 to 2021. Patient information, including age, sex, and regional and seasonal data, were extracted. The Joinpoint regression program was used to determine the age-adjusted incidence rate (AAR) per 100,000 population, annual percentage change (APC), and average APC (AAPC).<h4>Results</h4>A total of 1047 cases of disseminated cryptococcosis were reported, of which those aged ≥ 70 years accounted for 68.8%. The AAR in men was significantly higher than that in women (median: 0.13 vs. 0.09: p = 0.0024). APC for the overall cases increased by 9.9% (95% confidence interval [95% CI] - 5.4-27.7) from 2015 to 2018 and then decreased by 3.3% (95% CI - 15.5-10.7) from 2018 to 2021. AAPC for the entire study period was 3.1% (95% CI - 1.5-8.0), indicating a possible increase in its number, although not statistically significant. In terms of regional distribution, the average AAR was highest in Shikoku District (0.17) and lowest in Hokkaido District (0.04). Northern Japan exhibited a significantly lower median AAR (median [interquartile range]: 0.06 [0.05, 0.08]) than the Eastern (0.12 [0.12, 0.13]), Western (0.11 [0.10, 0.13]), and Southern (0.14 [0.12, 0.15]) regions. No seasonal variation in incidence was observed.<h4>Conclusion</h4>The prevalence of disseminated cryptococcosis has not increased in Japan. Geographically, the incidence is lower in Northern Japan. Further investigations that incorporate detailed clinical data are required.

DOI： 10.1007/s11046-023-00814-1

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本邦の小児肥満有病率の10年間の推移 Joinpoint regressionを用いた小児肥満トレンド解析 Reviewed International coauthorship

藤原進太郎, 原田洸, 萩谷英大, 小山敏広, 長谷川高誠, 塚原宏一, 大塚文男

日本内分泌学会雑誌 99 ( 4 ) 1052 - 1052 2024.1

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Trends in childhood obesity in Japan: A nationwide observational study from 2012 to 2021. (in press) Reviewed International coauthorship International journal

Shintaro Fujiwara, Ko Harada, Hideharu Hagiya, Toshihiro Koyama, Kosei Hasegawa, Hirokazu Tsukahara, Fumio Otsuka

Clinical Obesity 2023.12

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Epidemiological Characteristics and Trends in the Incidence of Leptospirosis in Japan: A Nationwide, Observational Study from 2006 to 2021. Reviewed International journal

Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

The American journal of tropical medicine and hygiene 109 ( 3 ) 589 - 594 2023.9

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During this age of climate change, the incidence of tropical diseases may change. This study compared the epidemiological characteristics and trends of leptospirosis in Japan between the endemic region, Okinawa, and the rest of the country. Infectious Diseases Weekly Reports were used to determine the numbers and crude incidence rates of leptospirosis. Data were stratified by sex, age, the estimated location of the infection, the notified regions, and the reporting month. A joinpoint regression analysis was performed to estimate the annual percentage change (APC). During the 16-year study period (2006-2021), 543 leptospirosis cases were reported, with male dominance (86.2%). Approximately half of these cases were reported from Okinawa (47.1%). The patients were relatively younger in Okinawa (20-29 years, 23.4%; 30-39 years, 20.7%) than outside Okinawa. The frequency of imported cases was significantly higher outside Okinawa (0.4% versus 14.3%). The incidences of leptospirosis in and outside Okinawa were apparently higher during the summer and typhoon seasons. The annual crude incidence ratios were 20-200 times higher in Okinawa than in the rest of the country. The average APCs for the entire study period in Okinawa and the rest of Japan were 1.6% (95% CI: -5.9 to 9.6) and -1.8% (95% CI: -7.8 to 4.6), respectively, without any particular trends. Collectively, the patient profile of leptospirosis differed between Okinawa (younger men) and outside Okinawa (middle- or older-aged men with a history of traveling abroad). The disease remains a neglected tropical disease; continuous surveillance with close monitoring is required.

DOI： 10.4269/ajtmh.23-0131

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Trends in the Incidence of Japanese Spotted Fever in Japan: A Nationwide, Two-Decade Observational Study from 2001-2020. Reviewed International coauthorship International journal

Yuki Otsuka, Hideharu Hagiya, Shinnosuke Fukushima, Ko Harada, Toshihiro Koyama, Fumio Otsuka

The American journal of tropical medicine and hygiene 2023.2

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The worldwide spread of tick-borne diseases (TBDs) has become a public health concern. Therefore, this study aimed to clarify trends in the incidence of Japanese spotted fever (JSF), one of Japan's most prevalent TBDs. Weekly infectious disease reports were used to calculate the annual incidence rates (AIRs) of JSF. Data were stratified by age and sex, and joinpoint regression analysis was performed to estimate the annual percentage change (APC). AIR and APC were geographically compared among the 47 prefectures. A total of 3,453 JSF cases were observed from 2001 to 2020. The AIR per 100,000 population was 0.03 in 2001, which increased approximately 10-fold to 0.33 in 2020. The average APC (AAPC) during the study period was 12.3% (95% CI: 10.7-13.9). By age group, the incidence of JSF increased more rapidly among the older population: 11.5% (95% CI: 10.1-12.9) in those aged ≥ 65 years and 8.9% (95% CI: 6.4-11.5) in those aged < 50 years. Although the AIR over the past two decades was higher in climatically warm regions located in southwestern Japan and on the Pacific coast, increases in the AAPC were notable in colder regions located in eastern Japan. The incidence of JSF continues to increase in Japan, especially among older populations and in eastern prefectures, where the disease has not been previously diagnosed.

DOI： 10.4269/ajtmh.22-0487

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Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. Reviewed International journal

Jun Matsumoto, Anzu Nishimoto, Shogo Watari, Hideo Ueki, Shoya Shiromizu, Naohiro Iwata, Tatsuaki Takeda, Soichiro Ushio, Makoto Kajizono, Masachika Fujiyoshi, Toshihiro Koyama, Motoo Araki, Koichiro Wada, Yoshito Zamami, Yasutomo Nasu, Noritaka Ariyoshi

Molecular and cellular biochemistry 478 ( 8 ) 1779 - 1790 2022.12

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UDP-glucuronosyltransferase (UGT) metabolizes a number of endogenous and exogenous substrates. Renal cells express high amounts of UGT; however, the significance of UGT in patients with renal cell carcinoma (RCC) remains unknown. In this study, we profile the mRNA expression of UGT subtypes (UGT1A6, UGT1A9, and UGT2B7) and their genetic variants in the kidney tissue of 125 Japanese patients with RCC (Okayama University Hospital, Japan). In addition, we elucidate the association between the UGT variants and UGT mRNA expression levels and clinical outcomes in these patients. The three representative genetic variants, namely, UGT1A6 541A > G, UGT1A9 i399C > T, and UGT2B7-161C > T, were genotyped, and their mRNA expression levels in each tissue were determined. We found that the mRNA expression of the three UGTs (UGT1A6, UGT1A9, and UGT2B7) are significantly downregulated in RCC tissues. Moreover, in patients with RCC, the UGT2B7-161C > T variant and high UGT2B7 mRNA expression are significantly correlated with preferable cancer-specific survival (CSS) and overall survival (OS), respectively. As such, the UGT2B7-161C > T variant and UGT2B7 mRNA expression level were identified as significant independent prognostic factors of CSS and CSS/OS, respectively. Taken together, these findings indicate that UGT2B7 has a role in RCC progression and may, therefore, represent a potential prognostic biomarker for patients with RCC.

DOI： 10.1007/s11010-022-04637-4

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Trends in the incidence of syphilis in the middle‐aged and older adults in Japan: A nationwide observational study, 2009–2019 International journal

Misa Takahashi, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

Geriatrics & Gerontology International 22 ( 12 ) 1019 - 1024 2022.11

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Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim

Sexually transmitted infections remain a neglected area of research in geriatrics. However, in the global aging societies, sexual health among the middle‐aged and older adults is an emerging public concern. High‐income countries are facing a resurgence of syphilis cases among young generations, but little is known about its prevalence in older populations. We aimed to investigate the national trend of syphilis cases in Japan.

Methods

This nationwide observational study used the publicly‐available database (2009–2019) to calculate crude and age‐adjusted incidence rates of syphilis per 100 000 population by age, sex and clinical stage. We collected data from patients aged ≥50 years and performed joinpoint regression analysis to estimate long‐term trends and average annual percentage changes (AAPCs).

Results

The total number of patients with syphilis increased about 8‐fold from 165 in 2009 to 1280 in 2019. AAPCs of crude incidence rates significantly increased in every age category; 33.2% in 50–59 years, 23.8% in 60–69 years and 20.9% in ≥70 years. Age‐adjusted incidence rates have surged at AAPCs of 28.7% in men and 23.1% in women, reaching 4.09 in men and 0.71 in women in 2019. By clinical stage, marked increases were observed in primary (AAPCs, 42.3% in men and 41.6% in women) and secondary syphilis (AAPCs, 24.9% in men and 24.2% in women).

Conclusions

An up‐toward trend of syphilis among people aged ≥50 years was observed. The importance of sexual health among older people should be highlighted in this aging Japanese society. Geriatr Gerontol Int 2022; 22: 1019–1024.

DOI： 10.1111/ggi.14500

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Impact of the cervical cancer awareness months on public interest in Japan: A Google Trends analysis, 2012–2021 International journal

Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

Scientific Reports 12 ( 1 ) 2022.9

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Abstract

The immunization and screening rates for human papillomavirus in Japan are lower than those in other countries. We aimed to evaluate the impact of cervical cancer awareness months on public attention using Google Trends analysis. Between 2012 and 2021, we analyzed the trends in relative search volumes (RSVs) for “Shikyuu-keigan” (cervical cancer in English) in Japan, during the cervical cancer awareness month (CCAM) in January and cervical cancer prevention awareness enhancement month (CCPAEM) in November. We performed a joinpoint regression analysis to identify a statistically significant trend change point. Additionally, we compared the mean RSVs of each awareness month with the rest of the year. Significant trend change points were observed, but none were found in CCAM and CCPAEM periods. Comparison of mean RSVs among CCAM, CCPAEM, and the rest of the months did not suggest any significant increases in RSVs during these awareness periods. In conclusion, CAM and CCPAEM did not raise public interest in cervical cancer in Japan. Although the results are based on internet users, the findings might suggest a need to develop a more effective and attractive approach to achieve the 90-70-90 targets of cervical cancer prevention by 2030.

DOI： 10.1038/s41598-022-19798-x

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Correlation between national surveillance and search engine query data on respiratory syncytial virus infections in Japan Reviewed International journal

Kazuhiro Uda, Hideharu Hagiya, Takashi Yorifuji, Toshihiro Koyama, Mitsuru Tsuge, Masato Yashiro, Hirokazu Tsukahara

BMC Public Health 22 ( 1 ) 2022.8

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Abstract

Background

The respiratory syncytial virus (RSV) disease burden is significant, especially in infants and children with an underlying disease. Prophylaxis with palivizumab is recommended for these high-risk groups. Early recognition of a RSV epidemic is important for timely administration of palivizumab. We herein aimed to assess the correlation between national surveillance and Google Trends data pertaining to RSV infections in Japan.

Methods

The present, retrospective survey was performed between January 1, 2018 and November 14, 2021 and evaluated the correlation between national surveillance data and Google Trends data. Joinpoint regression was used to identify the points at which changes in trends occurred.

Results

A strong correlation was observed every study year (2018 [r = 0.87, p < 0.01], 2019 [r = 0.83, p < 0.01], 2020 [r = 0.83, p < 0.01], and 2021 [r = 0.96, p < 0.01]). The change-points in the Google Trends data indicating the start of the RSV epidemic were observed earlier than by sentinel surveillance in 2018 and 2021 and simultaneously with sentinel surveillance in 2019. No epidemic surge was observed in either the Google Trends or the surveillance data from 2020.

Conclusions

Our data suggested that Google Trends has the potential to enable the early identification of RSV epidemics. In countries without a national surveillance system, Google Trends may serve as an alternative early warning system.

DOI： 10.1186/s12889-022-13899-y

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Trends in sarcoidosis mortality rate in Japan from 2001 to 2020: A population-based study International coauthorship International journal

Ko Harada, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

Respiratory Medicine 196 106828 - 106828 2022.5

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.rmed.2022.106828

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Impact of the world hand hygiene and global handwashing days on public awareness between 2016 and 2020: Google trends analysis Reviewed International coauthorship International journal

Yoshito Nishimura, Hideharu Hagiya, Koichi Keitoku, Toshihiro Koyama, Fumio Otsuka

American Journal of Infection Control 50 ( 2 ) 141 - 147 2022.2

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DOI： 10.1016/j.ajic.2021.08.033

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Trends in the amyloidosis mortality rate in <scp>J</scp>apan: A nationwide observational study from 1998 to 2019 International coauthorship International journal

Ko Harada, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

Geriatrics & Gerontology International 22 ( 3 ) 246 - 250 2022.1

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim

Despite the increasing attention that has been paid to amyloidosis in recent years, there have been few reports on amyloidosis mortality and its trends worldwide. This study aimed to evaluate the trends in crude and age‐adjusted amyloidosis‐associated mortality rates in Japan from 1998 to 2019.

Methods

We used national Vital Statistics data among older adults aged over 50 years. The data were analyzed using the joinpoint regression program to estimate the long‐term trends and average annual percentage changes (AAPCs).

Results

A total of 9158 amyloidosis‐associated deaths were recorded from 1998 to 2019, of which 56.1% were in men. The crude mortality rate per 1 000 000 older adults aged over 80 years increased from 9.65 to 54.3 among men and from 7.02 to 22.1 among women during the study period. Overall, the AAPCs of age‐adjusted amyloidosis‐associated mortality rates increased significantly over the study period (1.8%, 95% confidence interval [CI], 1.0–2.7%). While the annual percentage change (APC) of age‐adjusted mortality rates in women showed no significant change over the study period, the APC in men markedly increased in the 2013–2019 period (8.2%, 95% CI: 6.0–10.4%).

Conclusions

This study revealed an increasing trend in mortality associated with amyloidosis, and in particular a marked increase in mortality among men over the past 6 years. Considering its high mortality rate and susceptibility to the effects of an increasing population of older adults, amyloidosis deserves more attention from healthcare providers to improve the understanding of diagnosis, clinical treatment, and healthcare planning. Geriatr Gerontol Int 2022; 22: 246–250.

DOI： 10.1111/ggi.14348

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Impact of the World Antimicrobial Awareness Week on public interest between 2015 and 2020: A Google Trends analysis Reviewed International coauthorship International journal

Koichi Keitoku, Yoshito Nishimura, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

International Journal of Infectious Diseases 111 12 - 20 2021.10

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DOI： 10.1016/j.ijid.2021.08.018

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Impact of the World Inflammatory Bowel Disease Day and Crohn’s & Colitis Awareness Week on Population Interest between 2016 and 2020: Google Trends Analysis Reviewed International coauthorship International journal

Krixie Silangcruz, Yoshito Nishimura, Torrey Czech, Nobuhiko Kimura, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

2021.8

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Abstract

Background

More than 6 million people are affected by inflammatory bowel disease (IBD) globally. World IBD Day (WID; May 19) and Crohn’s and Colitis Awareness Week (CCAW; December 1–7) occur yearly as national health observances to raise public awareness of IBD, but their effects are unclear.

Methods

This study evaluates the impact of WID and CCAW on the public awareness of IBD in the United States (US) and worldwide from 2016 to 2020 using the relative search volume (RSV) of “IBD,” “Ulcerative colitis,” and “Crohn’s disease” in Google Trends (GT). To identify significant timepoints of trend changes (joinpoints), we performed Joinpoint regression analysis.

Results

No joinpoints were noted around the time of WID or CCAW during the study period in the search results of the US. Worldwide, joinpoints were noted around WID in 2020 with the search for “IBD” and around CAAW in 2017 and 2019 to search for “ulcerative colitis.” However, the extents of trend changes were modest without statistically significant increases.

Conclusions

WID and CCAD may not have worked as expected to raise public awareness of IBD. Additional measures are necessary to help raise awareness of IBD related to the health observances.

Summary

World IBD Day and Crohn’s and Colitis Awareness Week are key health observances related to IBD. These observances, however, might not have been effective in raising public awareness of IBD in the US and worldwide, according to Google Trends analysis.

DOI： 10.1101/2021.08.01.21261456

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Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma Reviewed International journal

JUN MATSUMOTO, YUMI KOTERA, SHOGO WATARI, KOICHI TAKEUCHI, HIDEO UEKI, TOSHIHIRO KOYAMA, KOICHIRO WADA, MASACHIKA FUJIYOSHI, YASUTOMO NASU, NORITAKA ARIYOSHI

Anticancer Research 41 ( 5 ) 2511 - 2521 2021.5

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Language：English Publishing type：Research paper (scientific journal) Publisher：International Institute of Anticancer Research

DOI： 10.21873/anticanres.15029

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Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan Reviewed International coauthorship International journal

Tomoko Funahashi, Toshihiro Koyama, Hideharu Hagiya, Ko Harada, Syunya Iinuma, Soichiro Ushio, Yoshito Zamami, Takahiro Niimura, Kazuaki Shinomiya, Keisuke Ishizawa, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

Drug Safety 44 ( 5 ) 531 - 539 2021.4

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DOI： 10.1007/s40264-020-01037-9

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Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017 Reviewed International journal

Shinnosuke Fukushima, Hideharu Hagiya, Yuki Otsuka, Toshihiro Koyama, Fumio Otsuka

Scientific Reports 11 ( 1 ) 2021.3

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Abstract

This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999–2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men’s age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: − 8.1, − 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999–2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.

DOI： 10.1038/s41598-021-86431-8

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A nationwide trend analysis in the incidence and mortality of Creutzfeldt–Jakob disease in Japan between 2005 and 2014 Reviewed International journal

Yoshito Nishimura, Ko Harada, Toshihiro Koyama, Hideharu Hagiya, Fumio Otsuka

Scientific Reports 10 ( 1 ) 2020.9

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DOI： 10.1038/s41598-020-72519-0

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Trends in Place of Death in a Super-Aged Society: A Population-Based Study, 1998–2017 Reviewed International journal

Toshihiro Koyama, Hideharu Hagiya, Tomoko Funahashi, Yoshito Zamami, Miyu Yamagishi, Hiroshi Onoue, Yusuke Teratani, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

Journal of Palliative Medicine 23 ( 7 ) 950 - 956 2020.7

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DOI： 10.1089/jpm.2019.0445

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日本人高齢者における転倒関連死死亡統計データを用いた20年間のトレンド解析 Reviewed

萩谷英大, 小山敏広, 樂木宏実, 狩野光伸

日本老年医学会雑誌 57 ( Suppl. ) 68 - 68 2020.7

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Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013–2015): A retrospective Observational Study International journal

Toshihiro Koyama, Hideharu Hagiya, Yusuke Teratani, Yasuhisa Tatebe, Ayako Ohshima, Mayu Adachi, Tomoko Funahashi, Yoshito Zamami, Hiroyoshi Y. Tanaka, Ken Tasaka, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

Journal of Infection and Chemotherapy 26 ( 7 ) 660 - 666 2020.7

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DOI： 10.1016/j.jiac.2020.02.001

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Trends in the Nontuberculous Mycobacterial Disease Mortality Rate in Japan: A Nationwide Observational Study, 1997–2016 Reviewed International journal

Ko Harada, Hideharu Hagiya, Tomoko Funahashi, Toshihiro Koyama, Mitsunobu R Kano, Fumio Otsuka

Clinical Infectious Diseases 73 ( 2 ) e321 - e326 2020.6

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan.

Methods

This study used vital statistics data and data on all NTM-associated deaths (N = 18 814) among individuals aged ≥40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpoint regression to analyze trends and estimate the average annual percentage change (AAPC). We compared crude NTM- and tuberculosis-associated mortality rates by sex.

Results

The overall crude annual mortality rate increased from 0.63/100 000/year in 1997 to 1.93/100 000/year in 2016 and was the highest among individuals aged 80–84 years. The AAPC of the crude mortality rates among men of all ages and women aged 40–59 years were stable but increased among women aged 60–79 years (3.5%; 95% confidence interval [CI], 2.8–4.3) and ≥80 years (4.3%; 95% CI, 3.7–4.9). Among men, the age-adjusted mortality rates did not show a significant trend, while among women, the rates increased over the study period (AAPC, 4.6%; 95% CI, 2.7–6.6). In women, the crude NTM-associated mortality rate exceeded the tuberculosis mortality rate in 2014, 2015, and 2016.

Conclusions

NTM mortality increased in Japan between 1997 and 2016, especially among the elderly female population. Given the increasing NTM-associated mortality and the susceptible aging population, public health authorities in Japan should pay greater attention to NTM infections.

DOI： 10.1093/cid/ciaa810

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日本における副作用に起因した死亡率の傾向に関する全国規模の観察研究

船橋智子, 小山敏広, 萩谷英大, 原田洸, 寺谷祐亮, 座間味義人, 建部泰尚, 三上奈緒子, 大島礼子, 四宮一昭, 北村佳久, 千堂年昭, 樋之津史郎, 狩野光伸

日本薬学会年会要旨集 140年会 28X - am11 2020.3

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Hypoglycemia associated with pivalate-conjugated antibiotics in young children: A retrospective study using a medical and pharmacy claims database in Japan Reviewed International journal

Yasuhisa Tatebe, Toshihiro Koyama, Naoko Mikami, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu

Journal of Infection and Chemotherapy 26 ( 1 ) 86 - 91 2020.1

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DOI： 10.1016/j.jiac.2019.07.013

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Place of death trends among patients with dementia in Japan: a population-based observational study Reviewed International journal

Toshihiro Koyama, Misato Sasaki, Hideharu Hagiya, Yoshito Zamami, Tomoko Funahashi, Ayako Ohshima, Yasuhisa Tatebe, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

Scientific Reports 9 ( 1 ) 2019.12

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Abstract

Dementia is a major public health concern in ageing societies. Although the population of Japan is among the most aged worldwide, long-term trends in the place of death (PoD) among patients with dementia is unknown. In this Japanese nationwide observational study, we analysed trends in PoD using the data of patients with dementia who were aged ≥65 years and died during 1999–2016. Trends in the crude death rates and PoD frequencies were analysed using the Joinpoint regression model. Changes in these trends were assessed using the Joinpoint regression analysis in which significant change points, the annual percentage change (APC) and average APCs (AAPC) in hospitals, homes, or nursing homes were estimated. During 1999–2016, the number of deaths among patients with dementia increased from 3,235 to 23,757 (total: 182,000). A trend analysis revealed increased mortality rates, with an AAPC of 8.2% among men and 9.3% among women. Most patients with dementia died in the hospital, although the prevalence of hospital deaths decreased (AAPC: -1.0%). Moreover, the prevalence of nursing home deaths increased (AAPC: 5.6%), whereas the prevalence of home deaths decreased (AAPC: -5.8%). These findings support a reconsideration of the end-of-life care provided to patients with dementia.

DOI： 10.1038/s41598-019-56388-w

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Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study Reviewed International journal

Hideharu Hagiya, Toshihiro Koyama, Yoshito Zamami, Yasuhisa Tatebe, Tomoko Funahashi, Kazuaki Shinomiya, Yoshihisa Kitamura, Shiro Hinotsu, Toshiaki Sendo, Hiromi Rakugi, Mitsunobu R Kano

BMJ Open 9 ( 12 ) e033462 - e033462 2019.12

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Objectives

Fall-related mortality among older adults is a major public health issue, especially for ageing societies. This study aimed to investigate current trends in fall-related mortality in Japan using nationwide population-based data covering 1997–2016.

Design

We analysed fall-related deaths among older persons aged ≥65 years using the data provided by the Japanese Ministry of Health, Labour and Welfare.

Results

The crude and age-standardised mortality rates were calculated per 100 000 persons by stratifying by age (65–74, 75–84 and ≥85 years) and sex. To identify trend changes, a joinpoint regression model was applied by estimating change points and annual percentage change (APC). The total number of fall-related deaths in Japan increased from 5872 in 1997 to 8030 in 2016, of which 78.8% involved persons aged ≥65 years. The younger population (65–74 years) showed continuous and faster-decreasing trends for both men and women. Average APC among men aged ≥75 years did not decrease. Among middle-aged and older women (75–84 and ≥85 years) decreasing trends were observed. Furthermore, the age-adjusted mortality rate of men was approximately twice that of women, and it showed a faster decrease for women.

Conclusions

Although Japanese healthcare has shown improvement in preventing fall-related deaths over the last two decades, the crude mortality for those aged over 85 years remains high, indicating difficulty in reducing fall-related deaths in the super-aged population. Further investigations to uncover causal factors for falls in older populations are required.

DOI： 10.1136/bmjopen-2019-033462

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Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database Reviewed International journal

Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, Mitsunobu R. Kano, Keisuke Ishizawa

Frontiers in Pharmacology 10 2019.11

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DOI： 10.3389/fphar.2019.01257

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Factors Associated With Immune Checkpoint Inhibitor–Related Myocarditis Reviewed International journal

Yoshito Zamami, Takahiro Niimura, Naoto Okada, Toshihiro Koyama, Keijo Fukushima, Yuki Izawa-Ishizawa, Keisuke Ishizawa

JAMA Oncology 5 ( 11 ) 1635 - 1635 2019.11

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DOI： 10.1001/jamaoncol.2019.3113

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Pattern of antibiotic prescriptions for outpatients with acute respiratory tract infections in Japan, 2013-15: A retrospective observational study Reviewed International journal

Yusuke Teratani, Hideharu Hagiya, Toshihiro Koyama, Mayu Adachi, Ayako Ohshima, Yoshito Zamami, Hiroyoshi Y. Tanaka, Yasuhisa Tatebe, Ken Tasaka, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Mitsunobu R. Kano, Shiro Hinotsu, Toshiaki Sendo

Family Practice 36 ( 4 ) 402 - 409 2019.8

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DOI： 10.1093/fampra/cmy094

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Antibiotic-associated adverse drug events at a Japanese academic hospital International journal

Ryohei Kokado, Hideharu Hagiya, Toshihiro Koyama, Eiko Matsui, Hideo Okuno, Daiichi Morii, Shigeto Hamaguchi, Hisao Yoshida, Yoshihiro Miwa, Kazunori Tomono

Journal of Infection and Chemotherapy 25 ( 5 ) 392 - 395 2019.5

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DOI： 10.1016/j.jiac.2018.11.002

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Oral anticoagulants usage in Japanese patients aged 18–74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data Reviewed International journal

Ayako Ohshima, Toshihiro Koyama, Aiko Ogawa, Yoshito Zamami, Hiroyoshi Y Tanaka, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Michael W Miller, Mitsunobu R Kano

Family Practice 36 ( 6 ) 685 - 692 2019.4

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Abstract

Background

Oral anticoagulants use has increased rapidly, internationally. Here we look at risks and benefits, based on Japanese data, of therapy with low risk non-valvular atrial fibrillation patients.

Objectives

Using a health insurance claims data set we assessed: (i) oral anticoagulants usage in Japan, and (ii) efficacy and safety of dabigatran compared with warfarin, in Japanese patients with non-valvular atrial fibrillation, aged 18–74 years.

Methods

We identified 4380 non-valvular atrial fibrillation patients treated with anticoagulants between 1 January 2005, and 28 February 2014, and estimated the adjusted hazard ratio for stroke or systemic embolism, and any hemorrhagic event (Cox proportional hazards regression model with stabilized inverse probability treatment weighting).

Results

The data included 101 989 anticoagulant prescriptions for 4380 patients, of which direct oral anticoagulants increased to 40.0% of the total by the end of the study. After applying exclusion criteria, 1536 new non-valvular atrial fibrillation patients were identified, including 1071 treated with warfarin and 465 with dabigatran. Mean ages were 56.11 ± 9.70 years for warfarin, and 55.80 ± 9.65 years for dabigatran. The adjusted hazard ratio (95% confidence interval), comparing dabigatran with warfarin, was 0.48 (0.25–0.91) for stroke or systemic embolism, and 0.91 (0.60–1.39) for any hemorrhage including intracranial and gastrointestinal.

Conclusions

Number of patients prescribed direct oral anticoagulants steadily increased, and incidence of all-cause bleeding related to dabigatran was similar to warfarin, in our study population of younger non-valvular atrial fibrillation patients. Dabigatran, compared with warfarin, generally reduced risk of all-cause stroke and systemic embolism.

DOI： 10.1093/fampra/cmz016

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Association between rapid antigen detection tests and antibiotics for acute pharyngitis in Japan: A retrospective observational study Reviewed International journal

Yusuke Teratani, Hideharu Hagiya, Toshihiro Koyama, Ayako Ohshima, Yoshito Zamami, Yasuhisa Tatebe, Ken Tasaka, Kazuaki Shinomiya, Yoshihisa Kitamura, Toshiaki Sendo, Shiro Hinotsu, Mitsunobu R. Kano

Journal of Infection and Chemotherapy 25 ( 4 ) 267 - 272 2019.4

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DOI： 10.1016/j.jiac.2018.12.005

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Trends in incidence and mortality of tuberculosis in Japan: a population-based study, 1997–2016 Reviewed International journal

H. Hagiya, T. Koyama, Y. Zamami, Y. Minato, Y. Tatebe, N. Mikami, Y. Teratani, A. Ohshima, K. Shinomiya, Y. Kitamura, T. Sendo, S. Hinotsu, K. Tomono, M. R. Kano

Epidemiology and Infection 147 2018.11

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Abstract

Japan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes. Crude and age-adjusted incidence rates reduced from 33.9 to 13.9 and 37.3 to 11.3 per 100 000 population, respectively. Also, crude and age-adjusted mortality rates reduced from 2.2 to 1.5 and 2.8 to 1.0 per 100 000 population, respectively. Average APC in the incidence and mortality rates showed significant decline both in men (−6.2% and −5.4%, respectively) and women (−5.7% and −4.6%, respectively). Age-specific analysis demonstrated decreases in incidence and mortality rates for every age category, except for the incidence trend in the younger population. Although trends in active TB incidence and mortality rates in Japan have favourably decreased, the rate of decline is far from achieving TB elimination by 2035.

DOI： 10.1017/s095026881800290x

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Trends in Polypharmacy in Japan: A Nationwide Retrospective Study Reviewed International journal

Hiroshi Onoue, Toshihiro Koyama, Yoshito Zamami, Hideharu Hagiya, Yasuhisa Tatebe, Naoko Mikami, Kazuaki Shinomiya, Yoshihisa Kitamura, Shiro Hinotsu, Toshiaki Sendo, Yasuyoshi Ouchi, Mitsunobu R. Kano

Journal of the American Geriatrics Society 66 ( 12 ) 2267 - 2273 2018.10

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Objectives

To describe and examine trends in polypharmacy according to age in Japan from 2010 to 2016.

Design

Retrospective observational study.

Setting

Outpatient settings.

Participants

Japanese individuals aged 20 and older.

Measurements

We analyzed pharmacy claims data that the Japanese Ministry of Health, Labor, and Welfare provided in the Survey of Medical Care Activities in Public Health Insurance from 2010 to 2016. The use of 5 or more oral prescription medications per month was defined as polypharmacy and of 10 or more as excessive polypharmacy. Regression analysis was used to estimate trends in polypharmacy with annual percentage changes. Using number of medications (polypharmacy vs excessive polypharmacy), trends in polypharmacy and crude and age‐adjusted rates of polypharmacy per 1,000 persons were calculated according to year and age group (20–34, 35–49, 50–64, 65–79, ≥ 80).

Results

We analyzed 240 million pharmacy claims data. The age‐adjusted monthly prevalence rate of polypharmacy increased from 85.2 to 93.8 per 1,000 persons per month and of excessive polypharmacy from 13.6 to 14.0 per 1,000 persons per month from 2010 to 2016 in the entire study population. The highest rate of polypharmacy (per 1,000 persons) was observed in 2016 in those aged 80 and older (326.8), followed by those aged 65 to 79 (167.3). The polypharmacy rate increased by 6.3% (95% confidence interval (CI)=4.0–8.7) per year from 2010 to 2012, then decreased by 0.7% (95% CI=–1.3–0.0) per year from 2012 to 2016. The rate of excessive polypharmacy increased by 4.5% (95% CI=1.1–8.0) per year from 2010 to 2013 and then decreased by 3.7% (95% CI=–6.7 to –0.6) per year from 2013 to 2016.

Conclusion

The overall trend of polypharmacy in Japan increased during the study period, although the increase ceased in 2013 and then declined from 2013 to 2016. Policy changes in Japan might be responsible for some of the changes. J Am Geriatr Soc 66:2267–2273, 2018.

DOI： 10.1111/jgs.15569

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Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit Reviewed International journal

Takahiro Niimura, Yoshito Zamami, Toru Imai, Kanako Nagao, Masafumi Kayano, Hidenori Sagara, Mitsuhiro Goda, Naoto Okada, Masayuki Chuma, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Tadashi Koga, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa

Journal of Pharmacy & Pharmaceutical Sciences 21 54 - 59 2018.3

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Purpose. Although the 2016 Japanese guidelines for the management of sepsis recommend de-escalation of treatment after identification of the causative pathogen, adherence to this practice remain unknown. The objective of this study was to evaluate the benefits of de-escalating treatment for sepsis patients at an advanced critical care and emergency medical centre. Methods. Based on electronic patient information, 85 patients who were transported to the centre by ambulance, and diagnosed with sepsis between January 2008 and September 2013 were enrolled and evaluated. Patients were divided into two groups with and without de-escalation, and comparisons were conducted for several variables, including length of hospital stay, and length of antibiotic administration. Two types of subgroup analysis were conducted between patients with septic shock or positive blood cultures. Statistical analysis was conducted using chi-square and Mann-Whitney U tests. Results. The length of hospital stay after diagnosis was significantly shorter for the de-escalation group than for the non-de-escalation group. In the subgroup analysis, de-escalation for blood culture-positive patients was beneficial in terms of the length of hospital stay and length of antibiotic administration. Conclusions. The findings of this study suggest that sepsis treatment de-escalation is beneficial for treatment efficacy and appropriate use of antibiotics. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

DOI： 10.18433/jpps29737

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Administration of Kampo medicine through a tube at an advanced critical care center. Reviewed

Takahiro Niimura, Yoshito Zamami, Toru Imai, Tsuyoshi Ito, Hidenori Sagara, Hichiya Hiroyuki, Satoru Esumi, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Manabu Amano, Naomi Kurata, Yoshihisa Kitamura, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa

The journal of medical investigation : JMI 65 ( 1.2 ) 32 - 36 2018

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n emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration. When the crushing method was employed, poorly water-soluble solid products were formed, while a uniformly dispersed suspension was obtained using the simple suspension method. In addition, the passage rate of amlodipine through the tube was 64% and 93% in the crushing and simple suspension methods, respectively, thereby indicating that the simple suspension method provided more favorable than the crushing method. The results of this study suggested that the passage rate of amlodipine for patients who received Kampo products concurrently was higher when the simple suspension method was used, and an appropriate drug amount might well be able to administered to patients using this method. J. Med. Invest. 65:32-36, February, 2018.

DOI： 10.2152/jmi.65.32

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Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation Reviewed International journal

Y. Zamami, Y. Kouno, T. Niimura, M. Chuma, T. Imai, M. Mitsui, T. Koyama, M. Kayano, N. Okada, H. Hamano, M. Goda, M. Imanishi, K. Takechi, Y. Horinouchi, Y. Kondo, H. Yanagawa, Y. Kitamura, T. Sendo, Y. Ujike, K. Ishizawa

Pharmazie 73 ( 12 ) 740 - 743 2018

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DOI： 10.1691/ph.2018.8711

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Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest. Reviewed International journal

Takahiro Niimura, Yoshito Zamami, Toshihiro Koyama, Yuki Izawa-Ishizawa, Masashi Miyake, Tadashi Koga, Keisaku Harada, Ayako Ohshima, Toru Imai, Yutaka Kondo, Masaki Imanishi, Kenshi Takechi, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya, Toshiaki Tamaki, Shiro Hinotsu, Mitsunobu R Kano, Keisuke Ishizawa

Scientific reports 7 ( 1 ) 17919 - 17919 2017.12

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There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60-10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.

DOI： 10.1038/s41598-017-17686-3

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Patterns of CT use in Japan, 2014: A nationwide cross-sectional study Reviewed

Toshihiro Koyama, Yoshito Zamami, Ayako Ohshima, Yusuke Teratani, Kazuaki Shinomiya, Yoshihisa Kitamura

EUROPEAN JOURNAL OF RADIOLOGY 97 96 - 100 2017.12

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DOI： 10.1016/j.ejrad.2017.10.023

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Trends in the medication reviews of community pharmacies in Japan: a nationwide retrospective study International journal

Toshihiro Koyama, Hiroshi Onoue, Ayako Ohshima, Yuri Tanaka, Yasuhisa Tatebe, Yoshito Zamami, Kazuaki Shinomiya, Yoshihisa Kitamura

International Journal of Clinical Pharmacy 40 ( 1 ) 101 - 108 2017.11

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DOI： 10.1007/s11096-017-0559-7

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Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia Reviewed International journal

Shiho Sato, Yoshito Zamami, Toru Imai, Satoshi Tanaka, Toshihiro Koyama, Takahiro Niimura, Masayuki Chuma, Tadashi Koga, Kenshi Takechi, Yasuko Kurata, Yutaka Kondo, Yuki Izawa-Ishizawa, Toshiaki Sendo, Hironori Nakura, Keisuke Ishizawa

Scientific Reports 7 ( 1 ) 2017.10

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DOI： 10.1038/s41598-017-13073-0

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Emotional intelligence and its effect on pharmacist and pharmacy students with autistic-like traits Reviewed International journal

Yuji Higuchi, Masatoshi Inagaki, Toshihiro Koyama, Yoshihisa Kitamura, Toshiaki Sendo, Maiko Fujimori, Hitomi Kataoka, Chinatsu Hayashibara, Yosuke Uchitomi, Norihito Yamada

American Journal of Pharmaceutical Education 81 ( 4 ) 2017.5

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DOI： 10.5688/ajpe81474

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Evaluation of pharmaceutical lifesaving skills training oriented pharmaceutical intervention Reviewed

Yoshito Zamami, Toru Imai, Masaki Imanishi, Kenshi Takechi, Naoko Shiraishi, Toshihiro Koyama, Hidenori Sagara, Yasukazu Shiino, Toshiaki Sendo, Keisuke Ishizawa

Journal of Pharmaceutical Health Care and Sciences 2 ( 1 ) 2016.9

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DOI： 10.1186/s40780-016-0054-7

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A cross-sectional study of psychological distress, burnout, and the associated risk factors in hospital pharmacists in Japan Reviewed International journal

Yuji Higuchi, Masatoshi Inagaki, Toshihiro Koyama, Yoshihisa Kitamura, Toshiaki Sendo, Maiko Fujimori, Yosuke Uchitomi, Norihito Yamada

BMC Public Health 16 ( 1 ) 2016.7

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DOI： 10.1186/s12889-016-3208-5

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Possibility of Pharmacist in Emergency Medical Care: To Bring Up a Familiar Pharmacist for Emergency Care by Fusing Clinical Pharmacist Activity and University Education International journal

Yoshito Zamami, Toshihiro Koyama, Hironori Nakura, Shuichi Enomoto

YAKUGAKU ZASSHI 136 ( 7 ) 965 - 965 2016.7

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DOI： 10.1248/yakushi.15-00286-f

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Pharmaceutical Education Focused on Pharmacotherapy in Emergency Medical Care International journal

Yoshito Zamami, Toshihiro Koyama, Toru Imai, Akane Takemoto, Hidenori Sagara, Toshiaki Sendo, Hironori Nakura

YAKUGAKU ZASSHI 136 ( 7 ) 987 - 991 2016.7

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DOI： 10.1248/yakushi.15-00286-4

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Vascular responses to compound 48/80 in rat mesenteric vascular beds Reviewed International coauthorship International journal

Honghua Jin, Zhen Li, Shingo Takatori, Toshihiro Koyama, Xin Jin, Yoshito Zamami, Hiromu Kawasaki, Pengyuan Sun

Canadian Journal of Physiology and Pharmacology 94 ( 6 ) 620 - 626 2016.6

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DOI： 10.1139/cjpp-2015-0442

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Exploring autistic-like traits relating to empathic attitude and psychological distress in hospital pharmacists Reviewed International journal

Yuji Higuchi, Yosuke Uchitomi, Maiko Fujimori, Toshihiro Koyama, Hitomi Kataoka, Yoshihisa Kitamura, Toshiaki Sendo, Masatoshi Inagaki

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY 37 ( 6 ) 1258 - 1266 2015.12

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DOI： 10.1007/s11096-015-0204-2

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The Effectiveness of Team-based Learning (TBL) as a New Teaching Approach for Pharmaceutical Care Education Reviewed

Manabu Suno, Toshiko Yoshida, Toshihiro Koyama, Yoshito Zamami, Tomoko Miyoshi, Takaaki Mizushima, Mitsune Tanimotoa

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 133 ( 10 ) 1127 - 1134 2013.10

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DOI： 10.1248/yakushi.12-00254

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The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats Reviewed International journal

Keiko Kuwatsuka, Hiromi Hayashi, Yuka Onoue, Ikuko Miyazaki, Toshihiro Koyama, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

Journal of Pharmacological Sciences 122 ( 1 ) 34 - 41 2013

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DOI： 10.1254/jphs.13015FP

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Influence of doxorubicin and cyclophosphamide on psychological behavior in rats Reviewed International journal

Kitamura Yoshihisa, Hattori Sayo, Miyake Ayaka, Koyama Toshihiro, Miyazaki Ikuko, Asanuma Masato, Sendo Toshiaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 143P 2013

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Effect of the 5-HT1A receptor function on antidepressive effect and neurogenesis in ACTH treated rats Reviewed International journal

Miyake Ayaka, Kitamura Yoshihisa, Hattori Sayo, Koyama Toshihiro, Miyazaki Ikuko, Asanuma Masato, Sendo Toshiaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 144P 2013

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Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries Reviewed International journal

Yuto Haruki, Shingo Takatori, Sayo Hattori, Yoshito Zamami, Toshihiro Koyama, Panot Tangsucharit, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 ( 4 ) 537 - 542 2012.4

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DOI： 10.1254/jphs.12012SC

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Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries Reviewed

Honghua Jin, Pengyuan Sun, Shingo Takatori, Toshihiro Koyama, Yoshito Zamami, Panot Tangsucharit, Yoshihisa Kitamura, Hiromu Kawasaki

EUROPEAN JOURNAL OF PHARMACOLOGY 680 ( 1-3 ) 73 - 80 2012.4

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DOI： 10.1016/j.ejphar.2012.01.018

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Investigation on the Mechanisms for the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in ACTH Treated Rats Reviewed International journal

Hiromi Hayashi, Maho Doi, Yuka Onoue, Keiko Kuwatsuka, Ayaka Miyake, Toshihiro Koyama, Kazuaki Shinomiya, Ikuko Miyazaki, Masato Aasanuma, Yoshihisa Kitamura

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 132 ( 2 ) 173 - 178 2012.2

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DOI： 10.1248/yakushi.132.173

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Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients Reviewed International journal

Junko Ohnishi, Akiyo Miyake, Keiko Kuwatsuka, Yuka Onoue, Miyoshi Lee, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Yoshihisa Kitamura

BIOLOGICAL & PHARMACEUTICAL BULLETIN 34 ( 10 ) 1609 - 1612 2011.10

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DOI： 10.1248/bpb.34.1609

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Histamine H-3 receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries Reviewed International journal

Pengyuan Sun, Shingo Takatori, Xin Jin, Toshihiro Koyama, Panot Tangsucharit, Simin Li, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

EUROPEAN JOURNAL OF PHARMACOLOGY 655 ( 1-3 ) 67 - 73 2011.3

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DOI： 10.1016/j.ejphar.2011.01.020

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Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats Reviewed International journal

Yoshihisa Kitamura, Maho Doi, Keiko Kuwatsuka, Yuka Onoue, Ikuko Miyazaki, Kazuaki Shinomiya, Toshihiro Koyama, Toshiaki Sendo, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

BIOLOGICAL & PHARMACEUTICAL BULLETIN 34 ( 1 ) 77 - 81 2011.1

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DOI： 10.1248/bpb.34.77

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Paracrine control of mesenteric perivascular axo-axonal interaction. Reviewed International journal

H Kawasaki, S Takatori, Yoshito Zamami, T Koyama, M Goda, K Hirai, P Tangsucharit, X Jin, N Hobara, Y Kitamura

Acta Physiologica Vol.203 ( No.1 ) 3 - 11 2010.11

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DOI： 10.1111/j.1748-1716.2010.02197.x

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Endothelial Modulation of Agonist-induced Vasoconstriction in Mesenteric Microcirculation Reviewed International journal

Xin Jin, Yukiko Otonashi-Satoh, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 130 ( 5 ) 723 - 728 2010.5

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Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats Reviewed International journal

Toshihiro Koyama, Yukako Hatanaka, Xin Jin, Ayako Yokomizo, Hidetoshi Fujiwara, Mitsuhiro Goda, Narumi Hobara, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

HYPERTENSION RESEARCH 33 ( 5 ) 485 - 491 2010.5

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DOI： 10.1038/hr.2010.48

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R-(-)-alpha-Methylhistamine, a Histamine H-3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries Reviewed International journal

Pengyuan Sun, Xin Jin, Toshihiro Koyama, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

BIOLOGICAL & PHARMACEUTICAL BULLETIN 33 ( 1 ) 58 - 63 2010.1

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DOI： 10.1248/bpb.33.58

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Chronic hyperinsulinemia induces hypertension resulted from abnormal innervation of perivascular nerves in rat mesenteric resistance arteries Reviewed International journal

Yoshito Zamami, Shingo Takatori, Nana Yabumae, Miho Hosoda, Toshihiro Koyama, Xin Jin, Narumi Hobara, Kenji Sasaki, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 76P - 76P 2010

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Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds Reviewed International journal

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 111 ( 4 ) 372 - 380 2009.12

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DOI： 10.1254/jphs.09183FP

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Proton Acts as a Neurotransmitter for Nicotine-Induced Adrenergic and Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in the Rat Mesenteric Artery Reviewed International journal

Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshihiro Koyama, Xin Jin, Yoshihisa Kitamura

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 330 ( 3 ) 745 - 755 2009.9

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DOI： 10.1124/jpet.108.149435

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腎血管性高血圧における血管周囲神経の機能変化 Reviewed

小山敏広, 畑中由香子, 合田光寛, 座間味義人, 芳原成美, 川崎博己

薬学雑誌 129 ( 2 ) 185 - 189 2009.2

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Functional Alteration of Nervous System in Renovascular Hypertension Reviewed

Toshihiro Koyama, Yukako Hatanaka, Mitsuhiro Goda, Yoshito Zamami, Narumi Hobara, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129 ( 2 ) 185 - 189 2009.2

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DOI： 10.1248/yakushi.129.185

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Young Pharmacological Researchers Develop the Way to Drug Discovery Based on Interpretation of Diseases and Medicinal Assessment: The Way to Create New Drugs by Fields Interchange Foreword Reviewed

Toshihiro Koyama, Sokichi Honda

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 129 ( 2 ) 183 - 183 2009.2

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DOI： 10.1248/yakushi.129.183

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Changes in neuronal regulation of vascular tone and its pathophysiological role in diabetic state Reviewed

Yoshito Zamami, Shingo Takatori, Yukiko Iwatani, Xin Jin, Toshihiro Koyama, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 25P - 25P 2009

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Royal jelly ameliorates insulin resistance in fructose-drinking rats. Reviewed

Yoshito Zamami, Shingo Takatori, Mitsuhiro Goda, Toshihiro Koyama, Yukiko Iwatani, Xin Jin, Shima Takai-Doi, Hiromu Kawasaki

Biological & pharmaceutical bulletin 31 ( 11 ) 2103 - 7 2008.11

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Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.

DOI： 10.1248/bpb.31.2103

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A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed Reviewed

Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

British Journal of Pharmacology 155 ( 6 ) 826 - 836 2008.11

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DOI： 10.1038/bjp.2008.313

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A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed Reviewed

Y. Hatanaka, Y. Zamami, T. Koyama, N. Hobara, X. Jin, Y. Kitamura, H. Kawasaki

BRITISH JOURNAL OF PHARMACOLOGY 155 ( 6 ) 826 - 836 2008.11

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DOI： 10.1038/bjp.2008.313

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Characterization of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric resistance arteries Reviewed

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 108 ( 1 ) 95 - 103 2008.9

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DOI： 10.1254/jphs.08115FP

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若手薬理研究者が展開する病態解明と薬効評価による創薬へのアプローチ領域を超えた交流から広がる創薬への道腎血管性高血圧ラット腸間膜動脈における血管周囲一酸化窒素含有神経の機能変化

小山敏広, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬学会年会要旨集 128年会 ( 1 ) 249 - 249 2008.3

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腎性高血圧ラット腸間膜動脈における血管周囲一酸化窒素含有神経機能変化

小山敏広, 庄司知世, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬理学雑誌 131 ( 3 ) 25p - 25p 2008.3

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[Effect of propolis on insulin resistance in fructose-drinking rats]. Reviewed

Yoshito Zamami, Shingo Takatori, Toshihiro Koyama, Mitsuhiro Goda, Yukiko Iwatani, Shima Doi, Hiromu Kawasaki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 127 ( 12 ) 2065 - 73 2007.12

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Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8 Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.

DOI： 10.1248/yakushi.127.2065

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高血圧モデルラットの腸間膜動脈における一酸化窒素含有神経の血管緊張度調節における機能変化

小山敏広, 庄司知世, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

日本薬理学雑誌 129 ( 2 ) 32P - 32P 2007.2

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2-Kidney,1-Clip(2K-1C)高血圧ラット腸間膜動脈における一酸化窒素(NO)含有神経による血管緊張度調節機能の減弱 Reviewed International journal

小山敏広, 庄司知世, 畑中由香子, 合田光寛, 芳原成美, 高山房子, 川崎博己

血管 30 ( 1 ) 28 - 28 2007.1

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ワルファリンを用いた抗凝固療法中の血液凝固能における季節変化の影響

小山敏広, 森英樹, 高山房子, 川崎博己, 柴田和彦, 五味田裕, 出石文男

日本薬学会年会要旨集 126年会 ( 2 ) 192 - 192 2006.3

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Histamine-induced vasodilation and vasoconstriction in the mesenteric resistance artery of the rat Reviewed International journal

H Jin, T Koyama, Y Hatanaka, S Akiyama, F Takayama, H Kawasaki

EUROPEAN JOURNAL OF PHARMACOLOGY 529 ( 1-3 ) 136 - 144 2006.1

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DOI： 10.1016/j.ejphar.2005.10.060

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Books

Emergency Pharmaceutical Science

Toshihiro KOYAMA（ Role： Joint author）

Kyoto Hirokawa 2015.3

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多様なビッグデータを活用した基礎と臨床の橋渡し研究

座間味義人, 座間味義人, 濱野裕章, 濱野裕章, 武田達明, 田中雄太, 山本和宏, 小山敏広

医療薬学フォーラム講演要旨集 32nd 2024

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RSウイルス感染症の全国サーベイランスとGoogle Trendsの相関性に関する検討

宇田和宏, 萩谷英大, 頼藤貴志, 小山敏広, 茂原研司, 津下充, 八代将登, 本田知之, 塚原宏一

日本小児感染症学会総会・学術集会プログラム・抄録集 54回 194 - 194 2022.11

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医学科1年生における手指衛生指導の実践と課題

越智可奈子, 三好智子, 小崎吉訓, 赤穂宗一郎, 小山敏広, 山下範之, 伊野英男, 松川昭博, 伊達勲

医学教育 53 ( Suppl. ) 185 - 185 2022.7

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術後せん妄発症予防に対する薬剤師参画「せん妄対策チーム」の効果的な介入に向けた検討

江角悟, 四宮一昭, 村川公央, 住江春香, 田村麻衣, 小山敏広, 牛尾聡一郎, 井上真一郎, 座間味義人, 北村佳久, 千堂年昭

日本病院薬剤師会雑誌 55 ( 9 ) 1071 - 1076 2019.9

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04451&link_issn=&doc_id=20190902290007&doc_link_id=%2Fdg4hppha%2F2019%2F005509%2F006%2F1071-1076%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg4hppha%2F2019%2F005509%2F006%2F1071-1076%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
大規模医療情報データベースを活用した周術期領域における薬剤疫学研究

座間味義人, 座間味義人, 石澤有紀, 新村貴博, 小山敏広, 濱野裕章, 岡田直人, 合田光寛, 武智研志, 中馬真幸, 堀ノ内裕也, 桐野靖, 中村敏己, 寺岡和彦, 石澤啓介, 石澤啓介

日本医療薬学会年会講演要旨集(Web) 29 2019

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Drug Repositioning Research Utilizing a Large-scale Medical Claims Database to Improve Survival Rates after Cardiopulmonary Arrest

Yoshito Zamami, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Keisuke Ishizawa

YAKUGAKU ZASSHI 137 ( 12 ) 1439 - 1442 2017.12

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DOI： 10.1248/yakushi.17-00139-3

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大規模医療情報に基づく炭酸リチウムの適正使用に関する検討

大島礼子, 小山敏広, 藤井里可, 坂本敦勇, 樋之津史郎, 狩野光伸

日本薬学会年会要旨集(CD-ROM) 137年会 ( 4 ) 60 - 60 2017.3

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新規心肺蘇生薬の開発を目指したドラッグリポジショニング研究

座間味義人, 今西正樹, 武智研志, 小山敏広, 大島礼子, 樋之津史郎, 狩野光伸, 石澤啓介

日本高血圧学会総会プログラム・抄録集 39th 437 2016.9

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救急医療における薬剤師の可能性を考える臨床現場の薬剤師活動と大学教育を融合し救急医療に精通した薬剤師を育成するには救急医療における薬物治療に主眼を置いた薬学教育

座間味義人, 小山敏広, 今井徹, 武本あかね, 相良英憲, 千堂年昭, 名倉弘哲

薬学雑誌 136 ( 7 ) 987 - 991 2016.7

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01459&link_issn=&doc_id=20160719230009&doc_link_id=130005159456&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130005159456&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif
Risk factor of acute renal failure induced by edaravone in patients with cerebrovascular disorder

ZAMAMI Yoshito, SAGARA Hidenori, KAYANO Yuka, KOYAMA Toshihiro, SHIRAISHI Naoko, ESUMI Satoru, UGAWA Toyomu, SENDO Toshiaki, UJIKE Yoshihito, NAKURA Hironori

Journal of Japanese Society for Emergency Medicine 19 ( 3 ) 461 - 465 2016.6

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DOI： 10.11240/jsem.19.461

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ドラッグリポジショニングを切り口とした新規心肺蘇生薬の探索研究―大規模医療情報を活用した検討―

座間味義人, 今西正樹, 武智研志, 小山敏広, 大島礼子, 今井徹, 樋之津史郎, 狩野光伸, 石澤啓介, 石澤啓介

医療薬学フォーラム講演要旨集 24th 193 2016.6

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レセプトデータを利用したピボキシル基含有抗菌剤による小児低血糖の発生頻度に関する研究

建部泰尚, 建部泰尚, 白石奈緒子, 小山敏広, 村川公央, 北村佳久, 樋之津史郎, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 136th ( 4 ) ROMBUNNO.27AB‐AM088 - 99 2016.3

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術後せん妄発症予防に対する「せん妄対策チーム」の効果的な介入に向けた取り組み~術後患者の睡眠状況からのアプローチ~

住江春香, 村川公央, 村川公央, 井上真一郎, 土山璃沙, 田村麻衣, 河本紫帆, 本郷志帆, 小山敏広, 馬場華奈己, 小田幸治, 伊藤真理, 足場孝子, 四宮一昭, 北村佳久, 北村佳久, 千堂年昭, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 136th ( 4 ) ROMBUNNO.27AB‐AM412S - 153 2016.3

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がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究抗がん治療の中止の際に医療者に望まれる行動に関する研究

内富庸介, 藤森麻衣子, 梅澤志乃, 白井由紀, 稲垣正俊, 樋口裕二, 藤原雅樹, 林原千夏, 北村佳久, 小山敏広, 長坂剛夫

がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究平成27年度総括・分担研究報告書 11‐13 2016

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がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究がん医療者に望まれる行動に関する研究

稲垣正俊, 樋口裕二, 千堂年昭, 北村佳久, 小山敏広, 片岡仁美, 林原千夏, 藤森麻衣子

がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究平成27年度総括・分担研究報告書 21‐23 2016

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心肺停止患者における社会復帰率の向上を志向したドラッグリポジショニング研究

座間味義人, 座間味義人, 今西正樹, 今西正樹, 小山敏広, 大島礼子, 樋之津史郎, 狩野光伸, 石澤啓介, 石澤啓介

日本薬学会年会要旨集(CD-ROM) 136th ROMBUNNO.S20‐4 2016

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非ビタミンK阻害経口抗凝固薬の有効性と安全性に関する臨床疫学研究

大島礼子, 小山敏広, 座間味義人, 小川愛子, 森田瑞樹, 冨田秀太, 樋之津史郎, 狩野光伸

日本計量生物学会年会講演予稿集 2016 41‐46 2016

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23-7-O62-17 経口医薬品の規格適正化がもたらす医療費削減効果の検証(薬剤疫学・医療経済,口頭発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

白石奈緒子, 小山敏広, 座間味義人, 建部泰尚, 大島礼子, 千堂年昭

日本医療薬学会年会講演要旨集 25 260 - 260 2015.10

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診療情報明細書情報に基づく安全性対策効果検証の取り組み:炭酸リチウムの適正使用に関する事例を中心に

小山敏広, 樋之津史郎, 大島礼子, 座間味義人, 白石奈緒子, 建部泰尚, 四宮一昭, 狩野光伸

Journal of Toxicological Sciences 40 ( Supplement ) S27 - 5 2015.6

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DOI： 10.14869/toxpt.42.1.0_S2-5

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「せん妄」発現予防並びに発現率低下に貢献する薬剤師業務プログラムの開発

北村佳久, 内富庸介, 小山敏広, 渡邊沙織, 千堂年昭, 村川公央

医療の広場 55 ( 3 ) 14 - 17 2015.3

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救急医療における薬剤師の可能性を考える臨床現場の薬剤師活動と大学教育を融合し救急医療に精通した薬剤師を育成するには救急医療における薬物治療に主眼を置いた薬学教育

座間味義人, 小山敏広, 今井徹, 武本あかね, 相良英憲, 千堂年昭, 名倉弘哲

日本薬学会年会要旨集 135年会 ( 1 ) 261 - 261 2015.3

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術後せん妄発症予防に対する薬剤師参画「せん妄対策チーム」の効果的な介入に向けたリスク因子の探索~飲酒に関する患者背景・因子からのアプローチ~

田村麻衣, 村川公央, 河本紫帆, 本郷志帆, 小山敏広, 土山璃沙, 馬場華奈己, 小田幸治, 伊藤真理, 足羽孝子, 井上真一郎, 四宮一昭, 北村佳久, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 135th ( 4 ) ROMBUNNO.26PB-AM156 - 156 2015.3

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救急医療における薬剤師業務に関する日本と諸外国との比較―よりよい救急薬剤師の確立を目指して―

座間味義人, 今井徹, 小山敏広, 武本あかね, 北村佳久, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 135th ( 4 ) ROMBUNNO.26PB-AM159 - 156 2015.3

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医療系学部生を対象としたJefferson Scale of Empathy Health Profession Students version(JSE‐HPS)日本語版の妥当性・信頼性の検討

藤井里可, 小山敏広, 四宮一昭, 千堂年昭, 北村佳久, 樋口裕二, 稲垣正俊, 片岡仁美, 林原千夏, 藤森麻衣子, 内富庸介

日本薬学会年会要旨集(CD-ROM) 135年会 ( 4 ) 243 - 243 2015.3

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薬物療法の実践に重点を置いた薬学生向け救命実務実習の評価

座間味義人, 相良英憲, 今井徹, 原直己, 武本あかね, 小山敏広, 名和秀起, 北村佳久, 氏家良人, 千堂年昭

日本注射薬臨床情報学会雑誌 4 11 - 21 2015

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がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究薬剤師に必要なコミュニケーションに関する研究

稲垣正俊, 樋口裕二, 千堂年昭, 北村佳久, 小山敏広, 片岡仁美, 林原千夏, 藤森麻衣子

がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究平成26年度総括・分担研究報告書 27‐28 2015

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がん患者が抱える精神心理的・社会的問題に関して,その原因や関連要因になり得る社会的要因に着目し,その是正を目指した研究がん医療者に望まれる行動に関する研究

内富庸介, 藤森麻衣子, 梅澤志乃, 冨川由紀, 稲垣正俊, 樋口裕二, 藤原雅樹, 林原千夏, 北村佳久, 小山敏広, 長坂剛夫

がん患者が抱える精神心理的・社会的問題に関して、その原因や関連要因になり得る社会的要因に着目し、その是正を目指した研究平成26年度総括・分担研究報告書 11‐13 2015

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27-O3PM-04 救急外来における初療への薬学的介入を志向した薬学生向け救命実技演習の開発(薬剤師外来,優秀演題候補セッション5,新時代を拓く医療薬学フロンティア)

座間味義人, 相良英憲, 今井徹, 原直己, 小山敏広, 武本あかね, 北村佳久, 千堂年昭, 名倉弘哲

日本医療薬学会年会講演要旨集 24 187 - 187 2014.8

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Utility of simple suspension method compared to loss of drug using crushing method on tube administration

ZAMAMI YOSHITO, KOYAMA TOSHIHIRO, AIBA TETSUYA, AMANO MANABU, ANDO TETSUAKI, KURATA NAOMI, NAWA HIDEKI, NAKURA HIRONORI, KITAMURA YOSHIHISA, SENDO TOSHIAKI

静脈経腸栄養 29 ( 4 ) 1027 - 1033 2014.7

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DOI： 10.11244/jjspen.29.1027

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薬物療法の実践に重点を置いたシミュレーション教育の有用性について

座間味義人, 小山敏広, 白石奈緒子, 武本あかね, 四宮一昭, 万代康弘, 狩野光伸, 千堂年昭, 須野学

日本薬学会年会要旨集(CD-ROM) 134th ROMBUNNO.30AMS-001 2014

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患者のジェネリック医薬品変更希望に影響を及ぼす患者背景・重要因子の探索―ジェネリック医薬品の適切な使用促進のために―

四宮一昭, 池方康一郎, 小山敏広, 山本和宏, 平野剛, 北村佳久, 平井みどり, 千堂年昭

日本薬剤師会雑誌 65 ( 11 ) 1323 - 1325 2013.11

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薬剤師職能の拡大への取り組みに関する基礎的研究~「薬剤師外来」設置が糖尿病の改善に与える影響~

北村佳久, 千堂年昭, 大西順子, 小山敏広, 尾上由華, 鍬塚圭子, 三宅昭代, 三宅彩香, 中村紘子, 米田沙緒里

医療の広場 53 ( 4 ) 12 - 16 2013.4

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抗がん剤投与患者に対する中枢神経系作用薬の処方に関する調査

山下佳晃, 北村佳久, 小山敏広, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 133rd ROMBUNNO.30AMF-559 2013

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術後せん妄早期発見ツールの探索を目指した危険因子・予測因子の調査

渡邊沙織, 北村佳久, 村川公央, 小山敏広, 千堂年昭

日本薬学会年会要旨集(CD-ROM) 133rd ROMBUNNO.30AMF-533 2013

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ラットの行動変化から推察する抗がん剤投与による精神機能変化―ドキソルビシンおよびシクロホスファミド投与による影響―

北村佳久, 服部紗代, 米田沙緒里, 三宅彩香, 小山敏広, 宮崎育子, 浅沼幹人, 千堂年昭

日本サイコオンコロジー学会総会プログラム・抄録集 26th 132 2013

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血液透析患者の貧血管理―病院薬剤師による積極的介入の2.5年後評価―

大西順子, 林雄一郎, 李美淑, 尾上由華, 鍬塚圭子, 三宅昭代, 小山敏広, 川崎博己, 北村佳久

日本病院薬剤師会雑誌 48 ( 5 ) 599 - 603 2012.5

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病院薬剤師の新たな業務展開としての「糖尿病薬剤師外来」の有用性についての検討―臨床検査値からの検討―

米田紗緒里, 大西順子, 中村紘子, 李美淑, 黒田真生, 小山敏広, 川崎博己, 名倉弘哲, 北村佳久

日本医療薬学会年会講演要旨集 21st 304 - 304 2011.9

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P-0589 経腸栄養剤を用いた疎水性薬剤の簡易懸濁法適用の検討(一般演題ポスター発表,医薬品情報・データベース,Enjoy Pharmacists' Lifestyles)

座間味義人, 松永康臣, 合葉哲也, 天野学, 小山敏広, 四宮一昭, 北村佳久, 黒崎勇二, 佐々木健二, 野田真吾, 千堂年昭, 川崎博己, 五味田裕

日本医療薬学会年会講演要旨集 21 280 - 280 2011.9

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病院薬剤師の新たな業務展開としての「糖尿病薬剤師外来」の有用性についての検討―アンケート調査からの検討―

中村紘子, 大西順子, 米田紗緒里, 李美淑, 黒田真生, 小山敏広, 川崎博己, 名倉弘哲, 北村佳久

日本医療薬学会年会講演要旨集 21st 304 - 304 2011.9

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ACTH反復投与ラットにおける海馬細胞新生の減少およびそのメカニズムに関する検討

林宏美, 土居真穂, 尾上由華, 鍬塚圭子, 三宅彩香, 小山敏広, 四宮一昭, 宮崎育子, 浅沼幹人, 北村佳久

日本薬学会年会要旨集 131st ( 1 ) 257 2011.3

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疎水性薬剤に対する経腸栄養剤を用いた簡易懸濁法適用の検討

松永康臣, 座間味義人, 大西順子, 小山敏広, 四宮一昭, 高取真吾, 北村佳久, 佐々木健二, 川崎博己, 野田真吾

日本薬学会年会要旨集 131年会 ( 4 ) 258 - 258 2011.3

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The different effects of histamine H1 receptor antagonists on histamine-induced vasodilation in rat mesenteric arteries

Yukimi Narahara, Sayo Hatutori, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Shingo Takatori, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 210P - 210P 2011

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Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in ACTH treated rats

Hiromi Hayashi, Maho Doi, Yuka Onoue, Keiko Kuwatsuka, Ayaka Miyake, Toshihiro Koyama, Kazuaki Shinomiya, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 251P - 251P 2011

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血液透析患者における腎性貧血治療に対する薬剤師の関与の影響

三宅昭代, 大西順子, 尾上由華, 鍬塚圭子, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

日本医療薬学会年会講演要旨集 20th 397 - 397 2010.10

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P1-376 薬剤師および他職種を対象とした院内抗がん剤調製マニュアルの作成と評価(一般演題ポスター発表,癌薬物療法(その他),臨床から学び臨床へと還元する医療薬学)

林宏美, 名和秀起, 岡田健男, 川上英治, 晴田佑介, 杉本志保, 小山敏広, 四宮一昭, 松永尚, 北村佳久, 千堂年昭

日本医療薬学会年会講演要旨集 20 349 - 349 2010.10

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血液透析患者における血清intact‐PTH値管理に対する薬剤師関与の影響~活性型ビタミンD静注製剤パルス療法施行中の症例に着目して~

尾上由華, 大西順子, 鍬塚圭子, 三宅昭代, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

日本医療薬学会年会講演要旨集 20th 397 - 397 2010.10

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血液透析患者における血清リン・カルシウム値管理の適正化を目指した薬剤師の取り組み

鍬塚圭子, 大西順子, 尾上由華, 三宅昭代, 李美淑, 小山敏広, 四宮一昭, 川崎博己, 北村佳久

日本医療薬学会年会講演要旨集 20th 397 - 397 2010.10

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ラット腸間膜動脈におけるヒスタミン誘発血管弛緩反応に及ぼす塩酸レボカバスチンおよび塩酸オロパタジンの影響

KOYAMA TOSHIHIRO, NARAHARA YUKIMI, SON HOEN, RI SHIBIN, KIN SHIN, ZAMAMI YOSHITO, TAKATORI SHINGO, KITAMURA YOSHIHISA, KAWASAKI HIROMU

アレルギー・免疫 17 ( 4 ) 662 - 670 2010.3

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Characterization and age-related changes in endothelial modulation of vasoconstriction in resistance artery

Xin Jin, Yukiko Otonashi, Yoshito Zamami, Narumi Hobara, Toshihiro Koyama, Pengyuan Sun, Simin Li, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 112 18P - 18P 2010

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Proton as a Possible Neurotransmitter for Perivascular Axo-axonal Transmission in the Rat Mesenteric Resistance Artery

Hiromu Kawasaki, Satoko Miyashita, Yoshito Zamami, Toshihiro Koyama, Mitsunobu Goda, Xin Jin, Yukiko Iwatani

Tzu Chi Medical Journal 21 ( 2 ) 95 - 98 2009.6

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DOI： 10.1016/S1016-3190(09)60018-5

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腸間膜動脈抵抗血管の内皮細胞による血管緊張調節の特性

金シン, 音無由紀子, 座間味義人, 小山敏広, 孫鵬遠, 川村直美, 坪井崇, 山口康代, 上田太郎, 北村佳久, 川崎博己

日本薬学会年会要旨集 129th ( 1 ) 260 2009.3

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2‐Kidney,1‐Clip(2K‐1C)高血圧ラット腸間膜動脈の血管周囲交感神経亢進におけるAngiotensin受容体の関与

小山敏広, 畑中由香子, 芳原成美, 合田光寛, 座間味義人, 北村佳久, 川崎博已

血管 32 ( 1 ) 22 2009.1

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INHIBITORY EFFECT OF VASCULAR ENDOTHELIUM ON AGONIST-INDUCED VASOCONSTRICTION IN RAT MESENTERIC RESISTANCE ARTERIES DISAPPERS WITH AGEING

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Toshihiro Koyama, Peng Yuan Sun, Narumi Hobara, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF VASCULAR RESEARCH 46 108 - 108 2009

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Role of redox action in abnormal neuronal regulation of vascular tone induced by acute hyperinsulinemia correspond to postprandial hyperglycemia

Yoshito Zamami, Shingo Takatori, Yukiko Iwatani, Xin Jin, Toshihiro Koyama, Yoshihisa Kitamura, Hiromu Kawasaki

Journal of the Pharmaceutical Society of Japan 128 ( 0 ) 70 - 72 2008.9

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食後高血糖下における神経性血管調節の変化とレドックスの関与

座間味義人, 高取真吾, 岩谷有希子, JIN Xin, 小山敏広, 北村佳久, 川崎博己

生体機能と創薬シンポジウム要旨集 2008 70 - 72 2008.9

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Vascular nitric oxide (NO)containing nerves are decreased in regulation of adrenergic neurotransmission in mesenteric resistance arteries of early phase of 2-kidey 1-clip hypertensive rats

Toshihiro Koyama, Chiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 218P - 218P 2008

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フルクトース負荷インスリン抵抗性モデル(ラット)におけるPropolisによるインスリン抵抗性改善作用

座間味義人, 高取真吾, 小山敏広, 合田光寛, 岩谷有希子, 土井志真, 川崎博己

薬学雑誌 127 ( 12 ) 2065 - 2073 2007.12

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30-P2-26 超速効型インスリンアナログ自己注射製剤の低血糖に関する検討(副作用・有害事象,社会の期待に応える医療薬学を)

小山敏広, 畑中由香子, 秋山伸二, 足立恵子, 池田和人, 川崎博己

日本医療薬学会年会講演要旨集 17 329 - 329 2007.9

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フルクトース負荷早期における血管反応性の変化

薮前奈々, 細田美穂, 座間味義人, 金きょう, 合田光寛, 小山敏広, 高取真吾, 高山房子, 川崎博己

日本薬理学雑誌 130 ( 3 ) 12P - 12P 2007.9

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ケトライド系抗菌薬テリスロマイシンの副作用である意識消失発現機序解明に関する研究 (特集平成17年度高度医療研究)

畑中由香子, 小山敏広, 小谷宏行

逓信医学 59 ( 3 ) 174 - 178 2007.6

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Other Link： http://search.jamas.or.jp/link/ui/2008079971
フルクトース負荷ラットのインスリン抵抗性に及ぼすプロポリス長期投与の影響

小山敏広, 土井志真, 高取真吾, 座間味義人, 合田光寛, 高山房子, 見尾光庸, 川崎博己

日本薬学会年会要旨集 127年会 ( 2 ) 133 - 133 2007.3

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Vascular nitric oxide (NO)-containing nerves regulate adrenergic neurotransmission in mesenteric resistance arteries of hypertensive rat.

Toshihiro Koyama, Chiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 70P - 70P 2007

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Telithromycin inhibits vascular adrenergic neurotransmission in rat mesenteric artery

Yukako Hatanaka, Toshihiro Koyama, Narumi Hobara, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 144P - 144P 2007

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Vascular tone regulation of calcitonin gene-related peptide (CGRP)and nitric oxide (NO)-containing nerves in mesenteric resistance arteries of hypertensive rats.

Toshihiro Koyama, Tiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 145P - 145P 2007

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Neuronal nitric oxide inhibits the neurogenic norepinephrine release in rat mesenteric resistance arteries

Y Hatanaka, N Hobara, HH Jin, T Koyama, S Akiyama, F Takayama, H Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 100 282P - 282P 2006

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Histamine induces constriction and relaxation mediated by perivascular nerves in rat mesenteric resistance arteries without endothelium

H Jin, T Koyama, Y Hatanaka, F Takayama, H Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 97 72P - 72P 2005

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リアルワールドデータとゲノミクスの統合解析を通じた免疫療法誘発心筋炎の発症予測

Grant number：24KK0173 2024.09 - 2028.03

日本学術振興会科学研究費助成事業国際共同研究加速基金(海外連携研究)

座間味義人, 濱野裕章, 新村貴博, 松本准, 小山敏広, 山本和宏, 武田達明

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医療データサイエンスによる高齢者医療の疾病構造に関する臨床疫学研究

Grant number：22K10415 2022.04 - 2025.03

日本学術振興会科学研究費助成事業基盤研究(C)

小山敏広, 萩谷英大, 座間味義人, 樋之津史郎

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【研究分担】シナジー効果探索手法の構築と医療情報データベースへの適用

Grant number：20H05798 2020.10 - 2023.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (B) Grant-in-Aid for Transformative Research Areas (B)

座間味義人, 中馬真幸, 小山敏広, 石澤有紀, 石澤啓介

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Grant amount：\41600000 （ Direct expense: \32000000 、 Indirect expense：\9600000 ）

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An epidemiological study of the impact of healthcare policies on antibiotic prescribing for acute upper respiratory tract infections and acute diarrhea in pediatric outpatients

2019.11 - 2020.06

Research Institute of Healthcare Data Science

Toshihiro KOYAMA, Hideharu HAGIYA, Yoshito ZAMAMI, Mitsunobu KANO

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A clinical epidemiology research on disease structure and quality assessment of geriatric health care by utilizing health care big data

2019.04 - 2022.03

Ministry of Education, Culture, Sports, Science and Technology (MEXT) Japan Society for the Promotion of Science

Toshihiro KOYAMA, Hideharu HAGIYA, Yoshito ZAMAMI, Mitsunobu Kano, Shiro HINOTSU

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【研究代表】保健関連SDGsの達成に向けたビッグデータ・オープンデータの活用法の開発

2018.10 - 2019.01

Ministry of Education, Culture, Sports, Science and Technology (MEXT) the program for promoting the enhancement of research universities

Toshihiro KOYAMA, Mitsunobu KANO, Toshiaki SENDOYutaka KONDO, Yoshito ZAMAMI, Yoshihisa KITAMURA, Hideharu HAGIYA, Naoko SHIRAISHI, Yasuhisa TATEBE, Yusuke MINATO

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【研究代表】生活習慣病合併型心房細動における新規抗凝固療法の評価系の構築

2016.04 - 2019.03

Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grant-in-Aid for Young Scientists (B)

Toshihiro KOYAMA

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【研究分担】我が国初のメガホスピタルネットワーク実施調査：隠された各地域圏医療ニーズ・産業シーズの“見える化”: 我が国の未来を拓く地域の実現に関する調査研究

2014.11 - 2015.03

科学技術振興機構（JST）

森田潔, 狩野光伸, 佐藤法仁, 小山敏広

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Mechanisms of treatment-resistant depression on the basic study of hippocampal neurogenesis in ACTH-treated rats

Grant number：21590593 2009.04 - 2012.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

KITAMURA Yoshihisa, KAWASAKI Hiromu, ASANUMA Masato, KOYAMA Toshihiro

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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone(ACTH)-treated rats. The dopamine reuptake inhibitor bupropion and D2/D3 receptor agonist pramipexole significantly decreased the duration of immobility in normal and ACTH-treated rats. The infusions of bupropion and pramipexole into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. These findings suggest the antidepressant-like effect of bupropion and pramipexole to be related to levels of dopamine in the rat nucleus accumbens.
We previously reported that the chronic administration of ACTH significantly decreased the number of BrdU-positive cells in the subgranular zone of the hippocampal dentate gyrus. This effect was reversed by the coadministration of imipramine and lithium, and electroconvulsive stimuli for 14 days in ACTH-treated rats. These results support the notion that imipramine and lithium, and electroconvulsive stimuli would improve the efficacy of treatment for resistant depression by triggering cell proliferation.

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岡山大・小山氏ら、インフルエンザ死亡率増‐世界動向、09年の約5倍 Newspaper, magazine

株式会社薬事日報社薬事日報 https://www.yakuji.co.jp/entry105251.html 2023.9.12

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岡山大学大学院医歯薬学総合研究科の小山敏広准教授らの研究グループは、2009年以降、世界的にインフルエンザウイルスによる死亡率が高まっていることを明らかにした。09年に比べ18年はインフルエンザによる死亡率が4.8倍になっていた。地域差があり、西ヨーロッパや北米では死亡率は大きく増加する一方、日本の増加幅は世界平均を下回っていた。世界全体や各国でインフルエンザへの対策を講じるための基礎的なデータとして役立ててほしい考えだ。

小山氏らは、世界保健機関（WHO）が加盟国から収集し、公開している死因データを対象に解析。質の高い65カ国のデータを抽出し、01年から18年までのインフルエンザによる死亡率の推移を調べた。

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Greenville Business Magazine https://pr.greenvillebusinessmag.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality

PRtimes https://prtimes.jp/main/html/rd/p/000001628.000072793.html 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Luverne Journal https://smb.luvernejournal.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Alabama Now https://smb.alabamanow.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Albert Lea Tribune [Albert Lea, MN] https://smb.albertleatribune.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Intern Daily https://www.interndaily.com/reports/prnewswire-interndaily-news.html?rkey=20230901PH97910&filter=1622 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Kenbridge Victoria Dispatch https://smb.kenbridgevictoriadispatch.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Newspaper, magazine

City Journals https://pr.valleyjournals.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Columbia Business Monthly https://pr.columbiabusinessmonthly.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Newspaper, magazine

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Cordele Dispatch https://smb.cordeledispatch.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Davie County Enterprise Record https://smb.ourdavie.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Daily Leader https://smb.dailyleader.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

Americus Times-Recorder https://smb.americustimesrecorder.com/article/Scientists-from-Okayama-University-Analyze-Global-Trends-in-Influenza-Associated-Mortality?storyId=64f1da22d44aab45bf5140e4 2023.9

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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Scientists from Okayama University Analyze Global Trends in Influenza-Associated Mortality Internet

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