研究者詳細 - 内藤　宏道

論文 - 内藤　宏道

分割表示 193 件中 161 - 180 件目／全件表示 >>

Case of necrotizing fasciitis from streptococcus pyogenes (group A) treated successfully with negative-pressure wound therapy. 査読

Inaba M, Nozaki S, Fujiwara T, Hongou T, Uozumi M, Nakahara T, Akagi Y, Kojima T, Naito H, Nakao A.

Surgical Infections Case Reports. 1 142 - 145 2016年11月

The Clinical Application of Hydrogen as a Medical Treatment. 査読

Iida A, Nosaka N, Yumoto T. Knaup E. Naito H. Nishiyama C. Yamakawa Y. Tsukahara K. Terado M. Sato K. Ugawa T. Nakao A.

Acta Med Okayama 70 ( 5 ) 331 - 337 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Okayama University Medical School

In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogenʼs effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.

DOI： 10.18926/AMO/54590

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A successfully treated case of iliopsoas abscess affecting urinary tract infection caused by streptococcus sanguis. 査読

Takeuchi N, Emori K, Yoshitani M, Soneda J, Naito H, Yumoto T, Tsukahara K, Nakao A.

Surg Infect Case Rep. 1 ( 1 ) 123 - 125 2016年9月

Intraperitoneally administered, hydrogen-rich physiologic solution protects against postoperative ileus and is associated with reduced nitric oxide production 査読

Ayana Okamoto,Keisuke Kohama,Michiko Aoyama-Ishikawa,Hayato Yamashita,Noritomo Fujisaki,Taihei Yamada,Tetsuya Yumoto*,Nobuyuki Nosaka*,Hiromichi Naito*,Kohei Tsukahara*,Atsuyoshi Iida*,Keiji Sato*,Joji Kotani,Atsunori Nakao*

Surgery 160 ( 3 ) 623 - 631 2016年9月

A successfully treated case of iliopsoas abscess affecting urinary tract infection caused by streptococcus sanguis. 査読

Takeuchi N, Emori K, Yoshitani M, Soneda J, Naito H, Yumoto T, Tsukahara K, Nakao A

Surgical Infections Case Reports. 1 41 - 43 2016年2月

Soft tissue hematoma of the neck due to thyroid rupture with unusual mechanism 査読

Kohei Tsukahara*,Keiji Sato*,Tetsuya Yumoto*,Atsuyoshi Iida*,Nobuyuki Nosaka*,Michihisa Terado*,Hiromichi Naito*,Yorihisa Orita*,Tomoyuki Naito,Kentaro Miki,Mayu Sugihara,Satoko Nagao,Toyomu Ugawa*,Atsunori Nakao*

International Journal of Surgery Case Reports 26 217 - 220 2016年

Effects of antibiotics administration on the incidence of wound infection in percutaneous dilatational tracheostomy. 査読

Hagiya H, Naito H, Hagioka S, Okahara S, Morimoto N, Kusano

Acta Med Okayama 68 ( 2 ) 57 - 62 2014年8月

Acute methemoglobinemia caused by suicidal ingestion of liquid fertilizer 査読

Yasutoshi Kuroe, Hiromichi Naito, Junichi Sugiyama, Susumu Kawanishi, Naoki Morimoto, Shingo Hagioka

Clinical Toxicology 52 ( 7 ) 819 - 819 2014年8月

Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus Aureus Infection. 査読

Hagiya H, Hisatsune J, Kojima T, Shiota S, Naito H, Hagioka S, Morimoto N, Otsuka F, Sugai M.

Intern Med. 53 ( 8 ) 907 - 912 2014年3月

Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection

Hagiya Hideharu, Hisatsune Junzo, Kojima Taro, Shiota Sumiko, Naito Hiromichi, Hagioka Shingo, Morimoto Naoki, Otsuka Fumio, Sugai Motoyuki

Internal Medicine 53 ( 8 ) 907 - 912 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.<br>

DOI： 10.2169/internalmedicine.53.1746

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重症呼吸不全に対するAirway Pressure Release Ventilationの肺酸素化能および循環動態に与える影響の検討. 査読

岡原修司, 内藤宏道, 萩岡信吾, 森本直樹, 森松博史, 森田潔.

ICUとCCU 37 219 - 223 2013年12月

Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1. 査読

Danura T, Takeda Y, Shiraishi K, Naito H, Mizoue R, Sato S, Morita K.

J Neurosurg Anesthesiol 25 ( 3 ) 292 - 298 2013年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND:Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials.MATERIALS AND METHODS:In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 µg/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves.RESULTS:There was no significant difference in onset time between the 2 groups (the control group vs. the esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P<0.05), and esmolol prolonged the duration of ischemic depolarization causing 50% neuronal damage from 4.97 to 6.34 minutes (P<0.05). Logistic regression curves also indicated that esmolol has a neuroprotective effect from 3.77 to 7.74 minutes of ischemic duration (P<0.05), and esmolol prolonged the ischemic duration causing 50% neuronal damage from 4.26 to 4.91 minutes (P<0.05).

DOI： 10.1097/ana.0b013e31827fe3b1

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Effect of lidocaine on dynamic changes in cortical reduced nicotinamide adenine dinucleotide fluorescence during transient focal cerebral ischemia in rats 査読

Naito H, Takeda Y, Danura T, Kass IS, Morita K.

Neuroscience 235 59 - 69 2013年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Rats were subjected to 90 min of focal ischemia by occluding the left middle cerebral and both common carotid arteries. The dynamic changes in the formation of brain ischemic areas were analyzed by measuring the direct current (DC) potential and reduced nicotinamide adenine dinucleotide (NADH) fluorescence with ultraviolet irradiation. In the lidocaine group (n = 10), 30 min before ischemia, an intravenous bolus (1.5 mg/kg) of lidocaine was administered, followed by a continuous infusion (2 mg/kg/h) for 150 min. In the control group (n = 10), an equivalent amount of saline was administered. Following the initiation of ischemia, an area of high-intensity NADH fluorescence rapidly developed in the middle cerebral artery territory in both groups and the DC potential in this area showed ischemic depolarization. An increase in NADH fluorescence closely correlated with the DC depolarization. The blood flow in the marginal zone of both groups showed a similar decrease. Five minutes after the onset of ischemia, the area of high-intensity NADH fluorescence was significantly smaller in the lidocaine group (67% of the control; P = 0.01). This was likely due to the suppression of ischemic depolarization by blockage of voltage-dependent sodium channels with lidocaine. Although lidocaine administration did not attenuate the number of pen-infarct depolarizations during ischemia, the high-intensity area and infarct volume were significantly smaller in the lidocaine group both at the end of ischemia (78% of the control; P = 0.046) and 24 h later (P = 0.02). A logistic regression analysis demonstrated a relationship between the duration of ischemic depolarization and histologic damage and revealed that lidocaine administration did not attenuate neuronal damage when the duration of depolarization was identical. These findings indicate that the mechanism by which lidocaine decreases infarct volume is primarily through a reduction of the brain area undergoing NADH fluorescence increases which closely correlates with depolarization.

DOI： 10.1016/j.neuroscience.2013.01.010

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In Reply: 国際誌

Yoshimasa Takeda, Hiroshi Hashimoto, Koji Fumoto, Tetsuya Danura, Hiromichi Naito, Naoki Morimoto, Hiroshi Katayama, Soichiro Fushimi, Akihiro Matsukawa, Aiji Ohtsuka, Kiyoshi Morita

Anesthesiology 118 ( 2 ) 469 - 470 2013年2月

Emphysematous liver abscesses complicated by septic pulmonary emboli in patients with diabetes: two cases. 査読

Hagiya H, Kuroe Y, Nojima H, Otani S, Sugiyama J, Naito H, Kawanishi S, Hagioka S, Morimoto N.

Intern Med. 52 ( 1 ) 141 - 145 2013年2月

A Fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. 査読

Hagiya H, Okita S, Kuroe Y, Nojima H, Otani S, Sugiyama J, Naito H, Kawanishi S, Hagioka S, Morimoto N.

Intern Med. 52 ( 3 ) 397 - 402 2013年2月

Emphysematous Liver Abscesses Complicated by Septic Pulmonary Emboli in Patients with Diabetes: Two Cases

Hagiya Hideharu, Kuroe Yasutoshi, Nojima Hiroyoshi, Otani Shinkichi, Sugiyama Junichi, Naito Hiromichi, Kawanishi Susumu, Hagioka Shingo, Morimoto Naoki

Internal Medicine 52 ( 1 ) 141 - 145 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

An emphysematous liver abscess is a fatal condition that often occurs in patients with uncontrolled diabetes mellitus. I herein describe two cases of Klebsiella pneumoniae-induced emphysematous liver abscesses complicated by septic pulmonary emboli in patients with poorly controlled diabetes mellitus. Both patients showed hemoglobin A1c levels of more than 10% and did not present with any abdominal symptoms on admission. However, they were diagnosed and successfully treated with percutaneous transhepatic abscess drainage and antibiotics. This fatal disease should be taken into consideration in patients with uncontrolled diabetes mellitus who suffer from prolonged fevers and uncharacteristic general malaise.<br>

DOI： 10.2169/internalmedicine.52.8737

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A Fatal Case of Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp. equisimilis Possibly Caused by an Intramuscular Injection

Hagiya Hideharu, Okita Shunji, Kuroe Yasutoshi, Nojima Hiroyoshi, Otani Shinkichi, Sugiyama Junichi, Naito Hiromichi, Kawanishi Susumu, Hagioka Shingo, Morimoto Naoki

Internal Medicine 52 ( 3 ) 397 - 402 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

An 88-year-old man died of streptococcal toxic shock syndrome due to a group G streptococcus infection that was possibly caused by an intramuscular injection given 30 hours earlier in his right deltoid muscle. The causative pathogen was later identified to be Streptococcus dysgalactiae subsp. equisimilis (stG485). Although providing intramuscular injections is an essential skill of health care workers that is performed daily worldwide, it may constitute a port of entry for pathogens via skin breaches that can cause life-threatening infections. All invasive procedures should be carefully performed, especially when immunologically compromised patients are involved.<br>

DOI： 10.2169/internalmedicine.52.8846

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Co-infection with invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia after corticosteroid therapy. 査読国際誌

Hagiya H, Miyake T, Kokumai Y, Murase T, Kuroe Y, Nojima H, Sugiyama J, Naito H, Hagioka S, Morimoto N.

J Infect Chemother. 19 ( 2 ) 342 - 347 2013年

Delftia acidovorans bacteremia caused by bacterial translocation after organophosphorus poisoning in an immunocompetent adult patient. 査読国際誌

Hagiya H, Murase T, Sugiyama J, Kuroe Y, Nojima H, Naito H, Hagioka S, Morimoto N.

J Infect Chemother. 19 ( 2 ) 338 - 341 2013年

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