Faculty Profiles - NAITOU Hiromichi

Papers - NAITOU Hiromichi

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Heat-not-burn cigarettes induce fulminant acute eosinophilic pneumonia requiring extracorporeal membrane oxygenation. Reviewed International journal

Aokage T, Tsukahara K, Fukuda Y, Tokioka F, Taniguchi A, Naito H, Nakao A

Respiratory medicine case reports 26 87 - 90 2019

Language：English

Background: Although the cause of acute eosinophilic pneumonia (AEP) has not yet been fully clarified, cigarette smoking is reported to be a risk factor for developing AEP. The heat-not-burn cigarette (HNBC) was developed to reduce the adverse effects of smoke on the user's surroundings. However, the health risks associated with HNBCs have not yet been clarified. We report a successfully treated case of fatal AEP presumably induced by HNBC use. Presentation of case: A 16-year-old man commenced HNBC smoking two weeks before admission and subsequently suffered from shortness of breath that gradually worsened. The patient was transferred to emergency department and immediately intubated because of respiratory failure. Computed tomography showed mosaic ground-glass shadows on the distal side of both lungs with a PaO2/FIO2 ratio of 76. The patient required veno-venous extracorporeal membrane oxygenation (ECMO) for severe respiratory failure. He was diagnosed with AEP by clinical course and detection of eosinophils in sputum; thus, methylprednisolone was administrated. The patient was weaned off ECMO four days after initiation and extubated the day after. He fully recovered without sequelae. Conclusion: As far as we know, our patient is the first case of AEP induced by HNBC use successfully treated with ECMO. Emergency physicians must be aware that HNBCs can induce fatal AEP.

DOI： 10.1016/j.rmcr.2018.12.002

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右内頸静脈穿刺による脱血での体外膜型肺を併用した心肺蘇生脱血カニューレに関して

内藤宏道, 平山隆浩, 塚原紘平

日本集中治療医学会雑誌 25 ( 6 ) 467 - 468 2018.11

Emphysematous cystitis successfully treated with hyperbaric oxygen therapy: case report

Hirotaka Yasuhara, Hiromichi Naito, Yoshinori Kosaki, Yasuaki Yamakawa, Atsuyoshi Iida, Tetsuya Yumoto, Hirotsugu Yamamoto, Taihei Yamada, Kohei Tsukahara, Takaaki Osako, Yasuhiro Mandai, Atsunori Nakao

UNDERSEA AND HYPERBARIC MEDICINE 45 ( 6 ) 701 - 703 2018.11

【ぜひ知っておきたい水・電解質異常と輸液管理】各種病態における輸液管理薬物中毒

小崎吉訓, 内藤宏道, 中尾篤典

臨牀と研究 95 ( 8 ) 871 - 875 2018.8

Cushing’s sign and severe traumatic brain injury in children after blunt trauma: a nationwide retrospective cohort study in Japan Reviewed

Tetsuya Yumoto, Hiromichi Naito, Takashi Yorifuji, Hiroki Maeyama, Yoshinori Kosaki, Hirotsugu Yamamoto, Kohei Tsukahara, Takaaki Osako, Atsunori Nakao

BMJ Open 8 ( 3 ) e020781 - e020781 2018.3

Publishing type：Research paper (scientific journal) Publisher：BMJ

<sec><title>Objective</title>We tested whether Cushing’s sign could predict severe traumatic brain injury (TBI) requiring immediate neurosurgical intervention (BI-NSI) in children after blunt trauma.

</sec><sec><title>Design</title>Retrospective cohort study using Japan Trauma Data Bank.

</sec><sec><title>Setting</title>Emergency and critical care centres in secondary and tertiary hospitals in Japan.

</sec><sec><title>Participants</title>Children between the ages of 2 and 15 years with Glasgow Coma Scale motor scores of 5 or less at presentation after blunt trauma from 2004 to 2015 were included. A total of 1480 paediatric patients were analysed.

</sec><sec><title>Primary outcome measures</title>Patients requiring neurosurgical intervention within 24 hours of hospital arrival and patients who died due to isolated severe TBI were defined as BI-NSI. The combination of systolic blood pressure (SBP) and heart rate (HR) on arrival, which were respectively divided into tertiles, and its correlation with BI-NSI were investigated using a multiple logistic regression model.

</sec><sec><title>Results</title>In the study cohort, 297 (20.1%) exhibited BI-NSI. After adjusting for sex, age category and with or without haemorrhage shock, groups with higher SBP and lower HR (SBP ≥135 mm Hg; HR ≤92 bpm) were significantly associated with BI-NSI (OR 2.84, 95% CI 1.68 to 4.80, P<0.001) compared with the patients with normal vital signs. In age-specific analysis, hypertension and bradycardia were significantly associated with BI-NSI in a group of 7–10 and 11–15 years of age; however, no significant association was observed in a group of 2–6 years of age.

</sec><sec><title>Conclusions</title>Cushing’s sign after blunt trauma was significantly associated with BI-NSI in school-age children and young adolescents.

</sec>

DOI： 10.1136/bmjopen-2017-020781

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Staphylococcus aureus Bacteremia Complicated by Psoas Abscess and Infective Endocarditis in a Patient with Atopic Dermatitis. Reviewed

Tsuboi I, Yumoto T, Toyokawa T, Matsueda K, Horii J, Naito H, Nakao A.

Case Rep Infect Dis 2017 2017.12

Indirect Calorimetry Measurement of Energy Expenditure Related to Body Position Changes in Healthy Adults. Reviewed

Kengo Obata, Tetsuya Yumoto, Soichiro Fuke, Kohei Tsukahara, Hiromichi Naito, Atsuyoshi Iida, Tetsuya Takahashi, Yoshihito Ujike, Atsunori Nakao

Acta medica Okayama 71 ( 6 ) 467 - 473 2017.12

Language：English Publishing type：Research paper (scientific journal)

Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. The subjects started in the resting supine position followed by a 30° head-up position, a 60° head-up position, an upright sitting position, a standing position, and the resting supine position. EE was determined in real time by indirect calorimetry monitoring the subject's respiratory rate, tidal volume (VT), and minute volume (MV). The highest values were observed immediately after the subjects transitioned from standing to supine, and this was significantly higher compared to the original supine position (1,450±285 vs. 2,004±519 kcal/day, p<0.01). Moderate correlations were observed between VT and EE (r=0.609, p<0.001) and between MV and EE (r=0.576, p<0.001). Increasing VT or MV indicates an increasing patient workload during mobilization. Monitoring these parameters may contribute to safe rehabilitation. Further studies should assess EE in critically ill patients.

DOI： 10.18926/AMO/55583

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Pneumatosis cystoides intestinalis presenting as pneumoperitoneum in a patient with chronic obstructive pulmonary disease: a case report Reviewed

Atsuyoshi Iida, Hiromichi Naito, Kohei Tsukahara, Tetsuya Yumoto, Nobuyuki Nosaka, Shinnichi Kawana, Keiji Sato, Nobuhiro Takeuchi, Jyunichi Soneda, Atsunori Nakao

Journal of Medical Case Reports 11 ( 1 ) 1 - 10 2017.12

Venous thromboembolism in major trauma patients: a single-center retrospective cohort study of the epidemiology and utility of D-dimer for screening Reviewed International journal

Tetsuya Yumoto, Hiromichi Naito, Yasuaki Yamakawa, Atsuyoshi Iida, Kohei Tsukahara, Atsunori Nakao

Acute Medicine & Surgery 4 ( 4 ) 394 - 400 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim: Venous thromboembolism (VTE) can be a life-threatening complication after major trauma. The aim of this study was to investigate the epidemiology of VTE and to assess the usefulness of D-dimer for screening for VTE in major trauma cases among the Japanese population. Methods: We examined a single-center retrospective cohort of severely injured trauma patients who had been admitted to the emergency intensive care unit at Okayama University Hospital (Okayama, Japan) from April 2013 through to March 2016. Venous thromboembolism was confirmed by computed tomography angiography and computed tomography venography, which was determined based on the attending physician monitoring daily D-dimer levels. Independent risk factors for VTE were determined by multiple logistic regression analysis. D-dimer levels were evaluated using area under the receiver operating characteristic curve (AUROC) to predict VTE. Results: The study cohort consisted of 204 trauma patients (median Injury Severity Score, 20). Of the 204 patients, 65 (32%) developed VTE. The median time from admission to VTE diagnosis was 10 days. In multiple logistic regression analysis, higher Injury Severity Score and the presence of lower extremity fractures were revealed to be a risk factor for VTE. D-dimer levels at day 10 showed moderate accuracy, of which the AUROC was 0.785 (95% confidence interval, 0.704-0.866; P < 0.001). The cut-off that maximized the Youden index was 12.45 μg/mL. Conclusions: At least one of every three major trauma patients had potential development of VTE at a median of 10 days following admission to the intensive care unit. D-dimer levels on day 10 can be a useful predictor of VTE.

DOI： 10.1002/ams2.290

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Occult Sources of Bleeding in Blunt Trauma : A Narrative Review.

Tetsuya Yumoto, Yoshinori Kosaki, Yasuaki Yamakawa, Atsuyoshi Iida, Hirotsugu Yamamoto, Taihei Yamada, Kohei Tsukahara, Hiromichi Naito, Takaaki Osako, Atsunori Nakao

Acta medica Okayama 71 ( 5 ) 363 - 368 2017.10

Language：English Publishing type：Research paper (scientific journal)

Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock. Chest/pelvic X-ray in conjunction with ultrasonography have been established classically as initial diagnostic imaging modalities to identify the major sources of internal bleeding including intra-thoracic, intra-abdominal, or retroperitoneal hemorrhage related to pelvic fracture. Massive soft tissue injury, regardless of whether isolated or associated with multiple injuries, occasionally causes extensive hemorrhage and acute traumatic coagulopathy. Specific types of injuries, including soft tissue injury or retroperitoneal hemorrhage unrelated to pelvic fracture, can potentially be overlooked or be considered "occult" causes of bleeding because classical diagnostic imaging often cannot exclude such injuries. The purpose of this narrative review article is to describe "occult" or unusual sources of bleeding associated with blunt trauma.

DOI： 10.18926/AMO/55433

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Multiple liver abscesses caused by streptococcus constellatus. Reviewed

Takeuchi N, Naito H, Yumoto T, Tsukahara K, Yamada T, Osako T, Soneda J, Nakao A.

Surgical Infections Case Reports 2 ( 1 ) 61 - 64 2017.7

A Successfully Treated Case of Criminal Thallium Poisoning. Reviewed International journal

Tetsuya Yumoto, Kohei Tsukahara, Hiromichi Naito, Atsuyoshi Iida, Atsunori Nakao

Journal of clinical and diagnostic research : JCDR 11 ( 4 ) OD01-OD02 2017.4

Language：English Publishing type：Research paper (scientific journal)

Thallium was once commonly used as a household rodent or ant killer, but many countries have banned such use due to unintentional or criminal poisonings of humans. A common initial clinical manifestation of thallium poisoning is gastrointestinal symptoms followed by delayed onset of neurological symptoms and alopecia. These clinical characteristics can provide important diagnostic clues regarding thallium poisoning. Here, we report a 23-year-old woman who was poisoned by a business colleague when she unknowingly drank tea containing the toxic substance several times. The patient was treated with multi-dose activated charcoal with airway protection and Prussian blue.

DOI： 10.7860/JCDR/2017/24286.9494

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右内頚静脈穿刺による脱血で体外膜型肺を併用し心肺蘇生を施行した4症例の検討． Reviewed

野島宏悦, 内藤宏道, 小崎吉訓, 杉山淳一, 大谷晋吉, 川西進, 萩岡信吾, 森本直樹.

日本集中治療医学会雑誌． 24 ( 2 ) 131 - 135 2017.3

Intraocular silicone oil masquerading as eye hemorrhage. Reviewed

Yamakawa Y, Naito H, Tsukahara K, Iida A, Yumoto T, Yamada T, Osako T, Nakao A.

J Trauma Treat 6 ( 1 ) 360 - 361 2017.2

A successfully treated case of penetrating facial trauma. Reviewed

Yumoto T, Iida A, Tsukahara K, Naito H, Terado M, Sato K, Date I, Nakao A.

Int J Case Rep Images 8 ( 2 ) 120 - 123 2017.2

Staphylococcus aureus Bacteremia Complicated by Psoas Abscess and Infective Endocarditis in a Patient with Atopic Dermatitis

Ichiro Tsuboi, Tetsuya Yumoto, Tatsuya Toyokawa, Katsunori Matsueda, Joichiro Horii, Hiromichi Naito, Atsunori Nakao

Case Reports in Infectious Diseases 2017 1 - 4 2017

Publishing type：Research paper (scientific journal) Publisher：Hindawi Limited

The close relationship between atopic dermatitis (AD) and infective endocarditis (IE) has been implicated. <italic>Staphylococcus aureus</italic> colonization is frequently seen observed in AD patients’ skin lesions. Although a case of IE due to <italic>S. aureus</italic> bacteremia in an AD patient has been sporadically reported, a case of <italic>S. aureus</italic> bacteremia complicated by psoas abscess and IE has not been previously reported. A 42-year-old man with a history of AD presented to our hospital complaining of fever, fatigue, chills, lower right back pain, and poor appetite for a week. His blood cultures showed growth of <italic>S. aureus</italic>. On day 3, the patient presented acute cardiac failure and was diagnosed with IE based on echocardiogram examination. Since the patient’s cardiac failure did not respond to medication, an emergency surgery was performed on the fourth day of hospitalization. The patient underwent successful surgical treatment of the heart lesions and subsequent percutaneous drainage of psoas abscess and received intensive antibiotics, which successfully improved his condition. Our report emphasizes awareness of the association between AD and invasive <italic>S. aureus</italic> infections.

DOI： 10.1155/2017/4920182

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Other Link： http://downloads.hindawi.com/journals/criid/2017/4920182.xml

Successfully-treated asymptomatic celiac artery aneurysm: A case report Reviewed International journal

Nobuhiro Takeuchi, Junichi Soneda, Hiromichi Naito, Atsuyoshi Iida, Tetsuya Yumoto, Kohei Tsukahara, Atsunori Nakao

International Journal of Surgery Case Reports 33 115 - 118 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

BACKGROUND: Celiac artery aneurysm is a rare vascular lesion. It is frequently discovered after rupture, which leads to death in most cases. We present a case of an asymptomatic celiac artery aneurysm discovered in a 72-year-old female during an evaluation for high grade fever and general fatigue. CASE PRESENTATION: The patient visited our department with complaints of fever and general fatigue. The patient's medical history included type 2 diabetes mellitus with poor control and hypertension. Blood culture and urine culture that were submitted at arrival presented E. Coli. Then, she was diagnosed with bacteremia by urinary tract infection. Transesophageal echocardiography revealed no vegetation at her valves. Computed tomography was performed for investigating her urological abnormalities, revealing a 28×30 mm aneurysm at the trunk of the celiac artery. Blood and urine cultures submitted at arrival were positive for E. coli. Surgical repair performed after the improvement of her urinary tract infection revealed a non-infective aneurysm; thus, aneurysm closure and prosthetic grafting were conducted. CONCLUSION: Clinician awareness regarding this rare entity and discovery efforts to discover the splanchnic aneurysm before rupturing are imperative.

DOI： 10.1016/j.ijscr.2017.02.018

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A case of traumatic cardiopulmonary arrest with good neurological outcome predicted by amplitude-integrated electroencephalogram Reviewed International journal

Ko Harada, Kohei Tsukahara, Tetsuya Yumoto, Yasuaki Yamakawa, Atsuyoshi Iida, Hiromichi Naito, Atsunori Nakao

International Journal of Surgery Case Reports 36 42 - 45 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

INTRODUCTION: Traumatic cardiopulmonary arrest has a very high mortality, and survival of patients with this condition without neurological disability is rare. PRESENTATION OF CASE: We herein report a case of traumatic cardiopulmonary arrest secondary to accidental amputation of the left lower leg that was successfully treated without any higher brain dysfunction. Although the long duration of cardiopulmonary arrest in this patient suggested hypoxic ischemic encephalopathy, amplitude-integrated electroencephalogram showed normal findings. DISCUSSION: This system may help intensivists evaluate the neurological conditions of patients with suspected hypoxic ischemic encephalopathy in the early stage of the clinical course and may assist in guiding therapeutic interventions. CONCLUSION: Our case supports the usefulness of neurological monitoring using amplitude-integrated electroencephalogram.

DOI： 10.1016/j.ijscr.2017.04.025

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A Successfully Treated Case of Criminal Thallium Poisoning International journal

Tetsuya Yumoto

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 11 ( 4 ) OD01-OD02 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：JCDR Research and Publications

DOI： 10.7860/jcdr/2017/24286.9494

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Impact of Cushing’s sign in the prehospital setting on predicting the need for immediate neurosurgical intervention in trauma patients: a nationwide retrospective observational study Reviewed

Tetsuya Yumoto, Toshiharu Mitsuhashi, Yasuaki Yamakawa, Atsuyoshi Iida, Nobuyuki Nosaka, Kohei Tsukahara, Hiromichi Naito, Atsunori Nakao

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 24 ( 1 ) 2016.12

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Papers - NAITOU Hiromichi