MISC - 杉生　憲志

Post coiling syndrome might predict recurrence after coil embolization of unruptured cerebral aneurysms.

Okuma Y, Sugiu K, Hirotsune N, Hishikawa T, Muraoka K, Hiramatsu M, Nishino S, Date I

Journal of Neuroendovascular Therapy   11 ( 5 )   235 - 239   2017年

　詳細を見る

DOI： 10.5797/jnet.oa.2016-0092

researchmap

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats 国際誌

Jun Haruma, Kiyoshi Teshigawara, Tomohito Hishikawa, Dengli Wang, Keyue Liu, Hidenori Wake, Shuji Mori, Hideo Kohka Takahashi, Kenji Sugiu, Isao Date, Masahiro Nishibori

SCIENTIFIC REPORTS   6   doi: 10.1038/srep37755 - 37755   2016年11月

　詳細を見る

記述言語：英語   出版者・発行元：NATURE PUBLISHING GROUP  

Although delayed cerebral vasospasm (DCV) following subarachnoid hemorrhage (SAH) is closely related to the progression of brain damage, little is known about the molecular mechanism underlying its development. High mobility group box-1 (HMGB1) plays an important role as an initial inflammatory mediator in SAH. In this study, an SAH rat model was employed to evaluate the effects of anti-HMGB1 monoclonal antibody (mAb) on DCV after SAH. A vasoconstriction of the basilar artery (BA) associated with a reduction of nuclear HMGB1 and its translocation in vascular smooth muscle cells were observed in SAH rats, and anti-HMGB1 mAb administration significantly suppressed these effects. Upregulations of inflammation-related molecules and vasoconstriction-mediating receptors in the BA of SAH rats were inhibited by anti-HMGB1 mAb treatment. Anti-HMGB1 mAb attenuated the enhanced vasocontractile response to thrombin of the isolated BA from SAH rats and prevented activation of cerebrocortical microglia. Moreover, locomotor activity and weight loss recovery were also enhanced by anti-HMGB1 mAb administration. The vasocontractile response of the BA under SAH may be induced by events that are downstream of responses to HMGB1-induced inflammation and inhibited by anti-HMGB1 mAb. Anti-HMGB1 mAb treatment may provide a novel therapeutic strategy for DCV and early brain injury after SAH.

DOI： 10.1038/srep37755

Web of Science

PubMed

researchmap

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

Jun Haruma, Kiyoshi Teshigawara, Tomohito Hishikawa, Dengli Wang, Keyue Liu, Hidenori Wake, Shuji Mori, Hideo Kohka Takahashi, Kenji Sugiu, Isao Date, Masahiro Nishibori

SCIENTIFIC REPORTS   6   doi: 10.1038/srep37755   2016年11月

　詳細を見る

記述言語：英語   出版者・発行元：NATURE PUBLISHING GROUP  

Although delayed cerebral vasospasm (DCV) following subarachnoid hemorrhage (SAH) is closely related to the progression of brain damage, little is known about the molecular mechanism underlying its development. High mobility group box-1 (HMGB1) plays an important role as an initial inflammatory mediator in SAH. In this study, an SAH rat model was employed to evaluate the effects of anti-HMGB1 monoclonal antibody (mAb) on DCV after SAH. A vasoconstriction of the basilar artery (BA) associated with a reduction of nuclear HMGB1 and its translocation in vascular smooth muscle cells were observed in SAH rats, and anti-HMGB1 mAb administration significantly suppressed these effects. Upregulations of inflammation-related molecules and vasoconstriction-mediating receptors in the BA of SAH rats were inhibited by anti-HMGB1 mAb treatment. Anti-HMGB1 mAb attenuated the enhanced vasocontractile response to thrombin of the isolated BA from SAH rats and prevented activation of cerebrocortical microglia. Moreover, locomotor activity and weight loss recovery were also enhanced by anti-HMGB1 mAb administration. The vasocontractile response of the BA under SAH may be induced by events that are downstream of responses to HMGB1-induced inflammation and inhibited by anti-HMGB1 mAb. Anti-HMGB1 mAb treatment may provide a novel therapeutic strategy for DCV and early brain injury after SAH.

DOI： 10.1038/srep37755

Web of Science

researchmap

「過灌流症候群高リスク例に対する頸動脈ステント留置術に関する後ろ向き研究」最終結果報告

早川 幹人, 菱川 朋人, 杉生 憲志, 山上 宏, 坂井 信幸, 飯原 弘二, 小笠原 邦昭, 大石 英則, 伊藤 靖, 松丸 祐司, 吉村 紳一

脳血管内治療   1 ( Suppl. )   S25 - S25   2016年11月

　詳細を見る

記述言語：日本語   出版者・発行元：(NPO)日本脳神経血管内治療学会  

researchmap

Moyamoya Disease: A Review of Clinical Research

Tomohito Hishikawa, Kenji Sugiu, Isao Date

ACTA MEDICA OKAYAMA   70 ( 4 )   229 - 236   2016年8月

　詳細を見る

記述言語：英語   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.

DOI： 10.18926/AMO/54497

Web of Science

PubMed

researchmap

Training guidelines for endovascular stroke intervention: an international multi-society consensus document

S. D. Lavine, K. Cockroft, B. Hoh, N. Bambakidis, A. A. Khalessi, H. Woo, H. Riina, A. Siddiqui, J. A. Hirsch, W. Chong, H. Rice, J. Wenderoth, P. Mitchell, A. Coulthard, T. J. Signh, C. Phatorous, M. Khangure, P. Klurfan, K. ter Brugge, D. Iancu, T. Gunnarsson, O. Jansen, M. Muto, I. Szikora, L. Pierot, P. Brouwer, J. Gralla, S. Renowden, T. Andersson, J. Fiehler, F. Turjman, P. White, A. C. Januel, L. Spelle, Z. Kulcsar, R. Chapot, A. Biondi, S. Dima, C. Taschner, M. Szajner, A. Krajina, N. Sakai, Y. Matsumaru, S. Yoshimura, M. Ezura, T. Fujinaka, K. Iihara, A. Ishii, T. Higashi, M. Hirohata, A. Hyodo, Y. Ito, M. Kawanishi, H. Kiyosue, E. Kobayashi, S. Kobayashi, N. Kuwayama, Y. Matsumoto, S. Miyachi, Y. Murayama, I. Nagata, I. Nakahara, S. Nemoto, Y. Niimi, H. Oishi, J. Satomi, T. Satow, K. Sugiu, M. Tanaka, T. Terada, H. Yamagami, O. Diaz, P. Lylyk, M. V. Jayaraman, A. Patsalides, C. D. Gandhi, S. K. Lee, T. Abruzzo, B. Albani, S. A. Ansari, A. S. Arthur, B. W. Baxter, K. R. Bulsara, M. Chen, J. E. Delgado Almandoz, J. F. Fraser, D. V. Heck, S. W. Hetts, M. S. Hussain, R. P. Klucznik, T. M. Leslie-Mawzi, W. J. Mack, R. A. McTaggart, P. M. Meyers, J. Mocco, C. J. Prestigiacomo, G. L. Pride, P. A. Rasmussen, R. M. Starke, P. J. Sunenshine, R. W. Tarr, D. F. Frei, M. Ribo, R. G. Nogueira, O. O. Zaidat, T. Jovin, I. Linfante, D. Yavagal, D. Liebeskind, R. Novakovic, S. Pongpech, G. Rodesch, M. Soderman, A. Taylor, T. Krings, D. Orbach, L. Picard, D. C. Suh, H. Q. Zhang

NEURORADIOLOGY   58 ( 6 )   537 - 541   2016年6月

　詳細を見る

記述言語：英語   出版者・発行元：SPRINGER  

DOI： 10.1007/s00234-016-1667-0

Web of Science

researchmap

Training Guidelines for Endovascular Ischemic Stroke Intervention: An International Multi-Society Consensus Document

S. D. Lavine, K. Cockroft, B. Hoh, N. Bambakidis, A. A. Khalessi, H. Woo, H. Riina, A. Siddiqui, J. A. Hirsch, W. Chong, H. Rice, J. Wenderoth, P. Mitchell, A. Coulthard, T. J. Signh, C. Phatorous, M. Khangure, P. Klurfan, K. terBrugge, D. Iancu, T. Gunnarsson, O. Jansen, M. Muto, I. Szikora, L. Pierot, P. Brouwer, J. Gralla, S. Renowden, T. Andersson, J. Fiehler, F. Turjman, P. White, A. C. Januel, L. Spelle, Z. Kulcsar, R. Chapot, L. Spelle, A. Biondi, S. Dima, C. Taschner, M. Szajner, A. Krajina, N. Sakai, Y. Matsumaru, S. Yoshimura, M. Ezura, T. Fujinaka, K. Iihara, A. Ishii, T. Higashi, M. Hirohata, A. Hyodo, Y. Ito, M. Kawanishi, H. Kiyosue, E. Kobayashi, S. Kobayashi, N. Kuwayama, Y. Matsumoto, S. Miyachi, Y. Murayama, I. Nagata, I. Nakahara, S. Nemoto, Y. Niimi, H. Oishi, J. Satomi, T. Satow, K. Sugiu, M. Tanaka, T. Terada, H. Yamagami, O. Diaz, P. Lylyk, M. V. Jayaraman, A. Patsalides, C. D. Gandhi, S. K. Lee, T. Abruzzo, B. Albani, S. A. Ansari, A. S. Arthur, B. W. Baxter, K. R. Bulsara, M. Chen, J. E. Delgado Almandoz, J. F. Fraser, D. V. Heck, S. W. Hetts, M. S. Hussain, R. P. Klucznik, T. M. Leslie-Mawzi, W. J. Mack, R. A. McTaggart, P. M. Meyers, J. Mocco, C. J. Prestigiacomo, G. L. Pride, P. A. Rasmussen, R. M. Starke, P. J. Sunenshine, R. W. Tarr, D. F. Frei, M. Ribo, R. G. Nogueira, O. O. Zaidat, T. Jovin, I. Linfante, D. Yavagal, D. Liebeskind, R. Novakovic, S. Pongpech, G. Rodesch, M. Soderman, K. terBrugge, A. Taylor, T. Krings, D. Orbach, A. Biondi, L. Picard, D. C. Suh, M. Tanaka, H. Q. Zhang

AMERICAN JOURNAL OF NEURORADIOLOGY   37 ( 4 )   E31 - E34   2016年4月

　詳細を見る

記述言語：英語   出版者・発行元：AMER SOC NEURORADIOLOGY  

DOI： 10.3174/ajnr.A4766

Web of Science

researchmap

岡山大学におけるHybrid ORでの手術

菱川朋人, 杉生憲志, 安原隆雄, 伊達 勲

脳卒中の外科   44 ( 2 )   125 - 131   2016年

　詳細を見る

DOI： 10.2335/scs.44.125

researchmap

LVIS を用いてステント併用コイル塞栓術を行った破裂脳底動脈本幹部紡錘状動脈瘤の1例

村井 智, 伊丹尚多, 馬越通有, 大塚真司, 日下 昇, 西浦 司, 荻原浩太郎, 杉生憲志

脳神経外科速報   26 ( 12 )   1318 - 1324   2016年

　詳細を見る

記述言語：日本語   出版者・発行元：(株)メディカ出版  

83歳女。頭痛・意識障害を主訴に救急搬送された。頭部CTにてクモ膜下出血を認め、脳血管撮影にて脳底動脈本幹部に10mm×5mm×3mm大の紡錘状動脈瘤を認め、LVISステントのflow diversion効果を期待し、ステント併用瘤内コイル塞栓を行う方針とした。瘤内へTarget Helical Ultraを部分的に挿入したうえでLVISを上小脳動脈起始部直下から前下小脳動脈起始部のやや下方まで瘤を十分カバーして展開し、瘤内の血流が残存していたため、jailing techniqueで瘤内に可能な限りコイルを挿入した。術翌日のMRIにてステントを留置した部分の穿通枝領域以外にカテーテル操作に伴う多発梗塞巣を認め、アスピリン、シロスタゾール、アルガトロバン、ファスジル塩酸塩投与を開始した。意識障害が遷延したが、術後1ヵ月目の脳室腹腔シャント術後より自動運動や発語を認め、術後3ヵ月に行った血管撮影ではLVISステントの良好な開存と動脈瘤の完全閉塞を認めた。

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J03120&link_issn=&doc_id=20161205100010&doc_link_id=issn%3D0917-1495%26volume%3D26%26issue%3D12%26spage%3D1318&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0917-1495%26volume%3D26%26issue%3D12%26spage%3D1318&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

バルーン閉塞試験（BOT）の重要性とピットフォール（Editorial Comment）

杉生憲志

脳神経外科ジャーナル   25 ( 9 )   783 - 783   2016年

　詳細を見る

researchmap

急速に発展する急性期脳梗塞への血管内治療

春間 純, 杉生憲志

medicina   53 ( 2 )   284 - 288   2016年

　詳細を見る

researchmap

Moyamoya disease: A review of clinical research

Tomohito Hishikawa, Kenji Sugiu, Isao Date

Acta Medica Okayama   70 ( 4 )   229 - 236   2016年

　詳細を見る

記述言語：英語   掲載種別：書評論文，書評，文献紹介等   出版者・発行元：Okayama University  

About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.

DOI： 10.18926/AMO/54497

Scopus

PubMed

researchmap

急速に発展する急性期脳梗塞への血管内治療.

春間 純, 杉生憲志

medicina   53 ( 2 )   284 - 288   2016年

　詳細を見る

researchmap

外傷性椎骨動静脈瘻に対してinternal trappingで治療した1例

西廣真吾, 杉生憲志, 菱川朋人, 平松匡文, 春間 純, 新治有径, 高杉祐二, 伊達 勲

脳神経外科   44 ( 2 )   135 - 141   2016年

　詳細を見る

記述言語：日本語   出版者・発行元：(株)医学書院  

66歳男。岩場で伐採作業中に誤って5m下の溝に滑落して前額部を打撲受傷し、直ちにドクターヘリで当院へ搬送された。頭部CTでは頭蓋内出血は認めず、頸椎CTにてC2椎体骨折、C6頸椎の右外側塊に骨折線を認めたため、頸椎カラーを装着して保存的加療となった。入院後に頸部雑音が出現したため頭頸部MRA・CTAを行ったところ、C2椎体骨折に伴う外傷性椎骨動静脈瘻が確認されたため、血管内治療によるinternal trappingを行った。治療後に頸部雑音は消失し、神経症状なく受傷後17日目にリハビリテーション目的に転院となった。

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01228&link_issn=&doc_id=20160219080011&doc_link_id=10.11477%2Fmf.1436203245&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1436203245&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

A case of traumatic vertebral arteriovenous fistula treated by internal trapping of the vertebral artery

Shingo Nishihiro, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Jun Haruma, Yukei Shinji, Yuji Takasugi, Isao Date

Neurological Surgery   44 ( 2 )   135 - 141   2016年

　詳細を見る

記述言語：日本語  

DOI： 10.11477/mf.1436203245

PubMed

researchmap

脳卒中Q & A─自身のスキルも上げつつ、若手に血管内治療を教育する方法は？─

杉生憲志

脳神経外科速報   26 ( 8 )   860 - 860   2016年

　詳細を見る

researchmap

第31回日本脳神経血管内治療学会学術総会（JSNET2015岡山）を終えて

杉生憲志

岡山医学会雑誌   128   151 - 153   2016年

　詳細を見る

researchmap

Transient middle cerebral artery occlusion model in the macaca fuscata using a novel intravascular technique

Okuma Y, Liu K, Hishikawa T, Hirotsune N, Sugiu K, Nishino S, Nishibori M, Date I

Journal of Neuroendovascular Therapy   10 ( 3 )   121 - 126   2016年

　詳細を見る

記述言語：英語   出版者・発行元：特定非営利活動法人 日本脳神経血管内治療学会  

Objective: The preparation of transient ischemic stroke models in monkeys has been highly invasive, and consistent preparation of an infarct area has been difficult. We attempted the preparation of a model by applying a neuroendovascular technique for humans.Methods: Using the Macaca fuscate, a 5 Fr sheath was placed in the right femoral artery under general anesthesia, a 5 Fr catheter was placed in the right internal carotid artery (ICA) via a bovine arch, a 4 Fr catheter was concentrically placed distally to the bifurcation of the posterior communicating artery (Pcom A), and a balloon catheter conventionally used for the prevention of distal embolism was guided to the origin of the M1 segment of the middle cerebral artery in a triple co-axial manner. Under antithrombotic treatment by heparinization, balloon occlusion was performed for 2 h, and neurological and histological evaluations were carried out 48 h after reperfusion.Results: Left hemiplegia was observed after the procedure, and ischemic changes were histopathologically confirmed around the head of the caudate nucleus located in the border zone of the territory of the occluded vessel.Conclusion: Less invasive and highly consistent transient ischemic stroke models may be prepared by an endovascular approach.

DOI： 10.5797/jnet.oa.2016-0044

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2017039204

Transient Middle Cerebral Artery Occlusion Model in the Macaca fuscata Using a Novel Intravascular Technique

Okuma Yu, Liu Keyue, Hishikawa Tomohito, Hirotsune Nobuyuki, Sugiu Kenji, Nishino Shigeki, Nishibori Masahiro, Date Isao

脳神経血管内治療   10 ( 3 )   121 - 126   2016年

　詳細を見る

記述言語：英語   出版者・発行元：特定非営利活動法人 日本脳神経血管内治療学会  

Objective: The preparation of transient ischemic stroke models in monkeys has been highly invasive, and consistent preparation of an infarct area has been difficult. We attempted the preparation of a model by applying a neuroendovascular technique for humans.Methods: Using the Macaca fuscate, a 5 Fr sheath was placed in the right femoral artery under general anesthesia, a 5 Fr catheter was placed in the right internal carotid artery (ICA) via a bovine arch, a 4 Fr catheter was concentrically placed distally to the bifurcation of the posterior communicating artery (Pcom A), and a balloon catheter conventionally used for the prevention of distal embolism was guided to the origin of the M1 segment of the middle cerebral artery in a triple co-axial manner. Under antithrombotic treatment by heparinization, balloon occlusion was performed for 2 h, and neurological and histological evaluations were carried out 48 h after reperfusion.Results: Left hemiplegia was observed after the procedure, and ischemic changes were histopathologically confirmed around the head of the caudate nucleus located in the border zone of the territory of the occluded vessel.Conclusion: Less invasive and highly consistent transient ischemic stroke models may be prepared by an endovascular approach.

DOI： 10.5797/jnet.oa.2016-0044

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2017039204

Dabigatran内服中の脳梗塞に対し血栓回収術を施行した1例（Editorial Comment）

杉生憲志

脳神経外科ジャーナル   25 ( 7 )   598 - 598   2016年

　詳細を見る

researchmap