Updated on 2025/07/25

写真a

 
TSURUTA Takeshi
 
Organization
Faculty of Environmental, Life, Natural Science and Technology Associate Professor
Position
Associate Professor
External link

Degree

  • 博士（農学） ( 北海道大学 )

Research Interests

  • 腸管免疫

  • 食品機能化学

Research Areas

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living

  • Life Science / Food sciences

Education

  • Hokkaido University    

    2007.4 - 2010.3

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  • 京都府立大学 大学院 博士前期課程    

    2005.4 - 2007.3

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  • Kyoto Prefectural University    

    2000.4 - 2005.3

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Research History

  • 岡山大学環境生命科学研究科動物栄養学研究室   准教授

    2015.5

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  • 北海道大学農学研究院   特任助教

    2013.11 - 2015.4

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  • Kyoto Prefectural University   Faculty of Life and Environmental Sciences   Researcher

    2011.2 - 2013.10

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  • Hokkaido University   Creative Research Institution   Researcher

    2010.4 - 2011.1

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Professional Memberships

  • JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE

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  • JAPANESE ASSOCIATION FOR DIETARY FIBER RESEARCH

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  • 日本食品免疫学会

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  • 岡山実験動物研究会

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Papers

  • Specific Heat-Killed Lactic Acid Bacteria Enhance Mucosal Aminopeptidase N Activity in the Small Intestine of Aged Mice. Reviewed International journal

    Takeshi Tsuruta, Mami Wakisaka, Takumi Watanabe, Aoi Nishijima, Akihito Ikeda, Mao Teraoka, Tianyang Wang, Kuiyi Chen, Naoki Nishino

    International journal of molecular sciences   26 ( 12 )   2025.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    Aminopeptidase N (APN), an enzyme expressed in the small intestinal mucosa, is involved in dietary protein digestion. Previous studies have shown that oral administration of fermented milk containing lactic acid bacteria (LAB) enhances mucosal APN activity in young mice. This study aimed to investigate whether LAB strains stimulate mucosal APN activity in aged mice and to evaluate its relevance to age-related changes in body composition. The underlying molecular mechanisms were also explored in vitro. Experiment 1: Aged C57BL/6J mice were fed diets supplemented with heat-killed LAB strains-Enterococcus faecalis OU-23 (EF), Leuconostoc mesenteroides OU-03 (LM), or Lactiplantibacillus plantarum SNK12 (LP). Compared to the aged Control group, the ileal APN activity was significantly higher in the LP group. LP administration also elevated serum Gla-osteocalcin levels and decreased serum CTX-1 levels. Experiment 2: IEC-6 cells were co-cultured with LP that had been treated with RNase, DNase, or lysozyme. APN activity was significantly lower in cells co-cultured with DNase- or lysozyme-treated LP compared to those co-cultured with untreated LP. A specific LAB strain may enhance mucosal APN activity in the aged intestine, potentially contributing to improved bone metabolism. This effect may be mediated by bacterial DNA and peptidoglycan.

    DOI： 10.3390/ijms26125742

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  • Extracellular vesicles shed by macrophages co-cultured with <i>Lactiplantibacillus plantarum</i> No. 14 reduce adipocyte size in mice fed a high-fat diet Reviewed

    Takeshi TSURUTA, Yohei ITO, Kei SONOYAMA

    Bioscience of Microbiota, Food and Health   2025

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    Publishing type：Research paper (scientific journal)   Publisher：BMFH Press  

    DOI： 10.12938/bmfh.2025-008

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  • Cyclic Oligosaccharide-Induced Modulation of Immunoglobulin A Reactivity to Gut Bacteria Contributes to Alterations in the Bacterial Community Structure Reviewed

    Taisei Miyamoto, Takeshi Tsuruta, Mao Teraoka, Tianyang Wang, Naoki Nishino

    Nutrients   16 ( 17 )   2824 - 2824   2024.8

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Immunoglobulin A (IgA) is a major gut antibody that coats commensal gut bacteria and contributes to shaping a stable gut bacterial composition. Although previous studies have shown that cyclic oligosaccharides, including cyclic nigerosyl-1,6-nigerose (CNN) and cyclodextrins (CDs, including αCD, βCD, and γCD), alter the gut bacterial composition, it remains unclear whether cyclic oligosaccharides modify the IgA coating of gut bacteria, which relates to cyclic oligosaccharide-induced alteration of the gut bacterial composition. To address this issue, mice were maintained for 12 weeks on diets containing CNN, αCD, βCD, or γCD; the animals’ feces were evaluated for their bacterial composition and the IgA coating index (ICI), a measure of the degree of IgA coating of bacteria. We observed that the intake of each cyclic oligosaccharide altered the gut bacterial composition, with changes in the ICI found at both the phylum and genus levels. The ICI for Bacillota, Lachnospiraceae NK4A136 group, UC Lachnospiraceae, and Tuzzerella were significantly and positively correlated with the relative abundance (RA) in total bacteria for these bacteria; in contrast, significant correlations were not seen for other phyla and genera. Our observations suggest that cyclic oligosaccharide-induced modulation of the IgA coating of gut bacteria may partly relate to changes in the community structure of the gut bacteria.

    DOI： 10.3390/nu16172824

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  • Unabsorbed Fecal Fat Content Correlates with a Reduction of Immunoglobulin a Coating of Gut Bacteria in High-Lard Diet-Fed Mice. Reviewed International journal

    Emiko Katsumata, Takeshi Tsuruta, Kei Sonoyama, Takashi Yoshida, Mio Sasaki, Mao Teraoka, Tianyang Wang, Naoki Nishino

    Molecular nutrition & food research   68 ( 15 )   e2400078   2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    SCOPE: Immunoglobulin A (IgA) selectively coats gut bacteria and contributes to regulatory functions in gastrointestinal inflammation and glucose metabolism. Excess intake of lard leads to decrease in the IgA coating of gut bacteria, although the underlying mechanisms remain unknown. This study validates how unabsorbed fat derived from a high-lard diet in the gut affects the IgA coating of bacteria, as assessed in mouse models using three types of dietary fat (lard, medium-, and long-chain triglycerides [MLCTs], and medium-chain triglycerides [MCTs]) exhibiting different digestibilities. METHODS AND RESULTS: C57BL/6J mice are maintained on diets containing lard, MLCTs, or MCTs at 7% or 30% w/w for 10 weeks (n = 6 per group). The fecal fatty acid concentration is measured to quantify unabsorbed fat content. The ratio of IgA-coated bacteria to total bacteria (IgA coating ratio) in the feces is measured by flow cytometry. Compared to lard-fed mice, MLCT- and MCT-fed mice exhibit lower fecal concentrations of palmitic acid, stearic acid, and oleic acid and higher IgA coating ratios at both 7% and 30% dietary fat, and these parameters exhibit significant negative correlations. CONCLUSION: Unabsorbed fat content in the gut may result in attenuated IgA coating of bacteria in high-lard diet-fed mice.

    DOI： 10.1002/mnfr.202400078

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  • Cyclic Nigerosylnigerose Attenuates High-Fat Diet-Induced Fat Deposition, Colonic Inflammation, and Abnormal Glucose Metabolism and Modifies Gut Immunoglobulin a Reactivity to Commensal Bacteria. Reviewed International journal

    Takeshi Tsuruta, Kei Sonoyama, Taisei Miyamoto, Qui D Nguyen, Akiko Mizote, Mao Teraoka, Naoki Nishino

    Molecular nutrition & food research   67 ( 14 )   e2200389   2023.7

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    SCOPE: High-fat diet (HFD) intake induces gut dysbiosis, inflammation in the peripheral tissues, and a reduction in immunoglobulin A (IgA) coating of gut bacteria, which is related to HFD-induced insulin resistance (IR). This study evaluates the effect of cyclic nigerosylnigerose (CNN), a dietary fiber that prevents gut inflammation and promotes IgA coating of gut bacteria, on the above-mentioned HFD-induced disorders. METHODS AND RESULTS: Balb/c mice are fed an HFD and administered CNN for 20 weeks. CNN administration reduces mesenteric adipose tissue weight, colonic tumor necrosis factor α (TNFα) mRNA expression, and serum endotoxin levels and ameliorates HFD-induced abnormal glucose metabolism. Additionally, CNN administration promotes gut bacteria-specific IgA secretion and alters IgA reactivity to gut bacteria. The alterations of IgA reactivity to specific bacteria such as Erysipelatoclostridium, Escherichia, Faecalibaculum, Lachnospiraceae genera, and Stenotrophomonas are correlated with mesenteric adipose tissue weight, colonic TNFα mRNA expression, serum endotoxin levels, and a homeostasis model assessment for IR. CONCLUSION: CNN-induced alterations in IgA reactivity to gut bacteria may be related to the suppression of HFD-induced fat deposition, colonic inflammation, endotoxemia, and IR. These observations indicate that dietary fiber that modulates IgA reactivity to gut bacteria may be useful in preventing HFD-induced disorders.

    DOI： 10.1002/mnfr.202200389

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  • Modulatory Effects of A1 Milk, A2 Milk, Soy, and Egg Proteins on Gut Microbiota and Fermentation. Reviewed International journal

    Nuomin, Riyang Baek, Takeshi Tsuruta, Naoki Nishino

    Microorganisms   11 ( 5 )   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Milk can be divided into A1 and A2 types according to β-casein variants, and there is a debate about whether A1 milk consumption exacerbates gut environments. This study examined the cecum microbiota and fermentation in mice fed A1 casein, A2 casein, mixed casein (commercial casein), soy protein isolate, and egg white. The cecum acetic acid concentration was higher, and the relative abundances of Muribaculaceae and Desulfovibrionaceae were greater in mice fed A1 versus A2 casein. The other parameters of cecum fermentation and microbiota composition were similar among the mice fed A1, A2, and mixed caseins. The differences were more distinctive among the three caseins, soy, and egg feedings. Chao 1 and Shannon indices of the cecum microbiota were lowered in egg white-fed mice, and the microbiota of mice fed milk, soy, and egg proteins were separately grouped by principal coordinate analysis. Mice fed the three caseins were characterized by a high abundance of Lactobacillaceae and Clostridiaceae, those fed soy were characterized by Corynebacteriaceae, Muribaculaceae, and Ruminococcaceae, and those fed egg white were characterized by Eggerthellaceae, Rikenellaceae, and Erysipelatoclostridiaceae. Thus, although several differences can arise between A1 and A2 caseins in terms of their modulatory effects on gut environments, the differences between milk, soy, and egg proteins can be more distinctive and are worth further consideration.

    DOI： 10.3390/microorganisms11051194

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  • Bacterial and fungal microbiota of total mixed ration silage stored at various temperatures. Reviewed International journal

    Ajmal Wali, Jianjian Hou, Takeshi Tsuruta, Naoki Nishino

    Journal of applied microbiology   133 ( 2 )   579 - 590   2022.8

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    AIMS: To obtain insights into how bacterial and fungal microbiota and fermentation products composition are affected by storage temperature for TMR silage, which can be manufactured year-round. METHODS AND RESULTS: TMR silage was stored at 10°C, 25°C, ambient temperature (AT; 20-35°C) and 40°C. Lactic acid production was delayed when stored at 10°C, and acid production stagnated after 2 weeks when stored at 40°C. The patterns of acetic acid and ethanol production were inversely related, with ethanol production promoted at 10°C and 25°C and acetic acid production promoted at AT and 40°C. The bacterial diversity was reduced in TMR silage with high lactic acid and acetic acid content, and the fungal diversity was reduced in TMR silage with high ethanol content. CONCLUSIONS: The intensity of lactic acid production was accounted for by the high abundance of Lactobacillus, and its stagnated production at a substantially high storage temperature was related to an increased abundance of Bacillus. The enhanced production of acetic acid or ethanol can be explained by differences in the fungal microbiota. SIGNIFICANCE AND IMPACT OF THE STUDY: The integrated analysis of bacterial and fungal microbiota can provide in-depth insights into the impact of storage temperature on TMR silage fermentation.

    DOI： 10.1111/jam.15582

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  • Fecal, Milk, Uterine, Airborne Dust, and Water Microbiota in Dairy Farms in Southern Vietnam: A Pilot Study Reviewed

    Tu Thi Minh Tran, Diep Hoang Tran, Thuong Thi Nguyen, Tomas J. Acosta, Takeshi Tsuruta, Naoki Nishino, Hai Thanh Duong

    Advances in Animal and Veterinary Sciences   10 ( 7 )   1525 - 1531   2022.7

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    DOI： 10.17582/journal.aavs/2022/10.7.1525.1531

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  • Local free fatty acids trigger the expression of lipopolysaccharide-binding protein in murine white adipose tissue Reviewed

    Manami SEKI, Akiho MIWA, Fumina OHSAKA, Yugo KARATSU, Takeshi TSURUTA, Shingo HINO, Tatsuya MORITA, Kei SONOYAMA

    Bioscience of Microbiota, Food and Health   41 ( 2 )   54 - 65   2022

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    Publishing type：Research paper (scientific journal)   Publisher：BMFH Press  

    DOI： 10.12938/bmfh.2021-061

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  • Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice Reviewed

    Takeshi Tsuruta, Teresia Aluoch Muhomah, Kei Sonoyama, Qui D. Nguyen, Yurika Takase, Aoi Nishijima, Shiori Himoto, Emiko Katsumata, Naoki Nishino

    Nutrition Research   93   15 - 26   2021.9

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.nutres.2021.06.009

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  • Consumption of indigestible saccharides and administration of Bifidobacterium pseudolongum reduce mucosal serotonin in murine colonic mucosa Reviewed

    Misa Tatsuoka, Yosuke Osaki, Fumina Ohsaka, Takeshi Tsuruta, Yoshihiro Kadota, Takumi Tochio, Shingo Hino, Tatsuya Morita, Kei Sonoyama

    British Journal of Nutrition   1 - 13   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Cambridge University Press (CUP)  

    <title>Abstract</title>
    SCFA increase serotonin (5-hydroxytryptamine, 5-HT) synthesis and content in the colon <italic>in vitro</italic> and <italic>ex vivo</italic>, but little is known <italic>in vivo</italic>. We tested whether dietary indigestible saccharides, utilised as a substrate to produce SCFA by gut microbiota, would increase colonic 5-HT content in mice. Male C57BL/6J mice were fed a purified diet and water supplemented with 4 % (w/v) 1-kestose (KES) for 2 weeks. Colonic 5-HT content and enterochromaffin (EC) cell numbers were lower in mice supplemented with KES than those without supplementation, while monoamine oxidase A activity and mRNA levels of tryptophan hydroxylase 1 (<italic>Tph1</italic>), chromogranin A (<italic>Chga</italic>), <italic>Slc6a4</italic> and monoamine oxidase A (<italic>Maoa</italic>) genes in the colonic mucosa, serum 5-HT concentration and total 5-HT content in the colonic contents did not differ between groups. Caecal acetate concentration and <italic>Bifidobacterium pseudolongum</italic> population were higher in KES-supplemented mice. Similar trends were observed in mice supplemented with other indigestible saccharides, that is, fructo-oligosaccharides, inulin and raffinose. Intragastric administration of live <italic>B. pseudolongum</italic> (108 colony-forming units/d) for 2 weeks reduced colonic 5-HT content and EC cell numbers. These results suggest that changes in synthesis, reuptake, catabolism and overflow of 5-HT in the colonic mucosa are not involved in the reduction of colonic 5-HT content by dietary indigestible saccharides in mice. We propose that gut microbes including <italic>B. pseudolongum</italic> could contribute to the reduction of 5-HT content in the colonic mucosa via diminishing EC cells.

    DOI： 10.1017/s0007114521001306

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  • Cecum microbiota in rats fed soy, milk, meat, fish, and egg proteins with prebiotic oligosaccharides. Reviewed International journal

    Souliphone Sivixay, Gaowa Bai, Takeshi Tsuruta, Naoki Nishino

    AIMS microbiology   7 ( 1 )   1 - 12   2021

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    Diet is considered the most influential factor in modulating the gut microbiota but how dietary protein sources differ in their modulatory effects is not well understood. In this study, soy, meat (mixture of beef and pork), and fish proteins (experiment 1) and soy, milk (casein), and egg proteins (experiment 2) were fed to rats with cellulose (CEL) and raffinose (RAF); the microbiota composition and short-chain fatty acid concentration in the cecum were determined. Egg protein feeding decreased the concentration of acetic acid and the richness and diversity of the cecum microbiota. RAF feeding increased the concentrations of acetic and propionic acids and decreased the richness and diversity of the cecum microbiota. When fed with CEL, the abundance of Ruminococcaceae and Christensenellaceae, Akkermansiaceae and Tannerellaceae, and Erysipelotrichaceae enhanced with soy protein, meat and fish proteins, and egg protein, respectively. The effects of dietary proteins diminished with RAF feeding and the abundance of Bifidobacteriaceae, Erysipelotrichaceae, and Lachnospiraceae increased and that of Ruminococcaceae and Christensenellaceae decreased regardless of the protein source. These results indicate that, although the effect of prebiotics is more robust and distinctive, dietary protein sources may influence the composition and metabolic activities of the gut microbiota. The stimulatory effects of soy, meat, and egg proteins on Christensenellaceae, Akkermansiaceae, and Erysipelotrichaceae deserve further examination to better elucidate the dietary manipulation of the gut microbiota.

    DOI： 10.3934/microbiol.2021001

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  • Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine Reviewed

    Motoshi Okumura, Akihiro Hamada, Fumina Ohsaka, Takeshi Tsuruta, Tohru Hira, Kei Sonoyama

    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY   472 ( 10 )   1521 - 1532   2020.10

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    DOI： 10.1007/s00424-020-02453-7

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  • Examination of milk microbiota, fecal microbiota, and blood metabolites of Jersey cows in cool and hot seasons. Reviewed International journal

    Qui D Nguyen, Takeshi Tsuruta, Naoki Nishino

    Animal science journal = Nihon chikusan Gakkaiho   91 ( 1 )   e13441   2020.1

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    Microbiota of individual cow milk, bulk tank milk, and feces of Jersey cows were examined. Samples were collected from two farms (F1 and F2) in cool (November, Nov) and hot (July, Jul) seasons. Milk yield and milk composition were similar between the two farms and between the two seasons. Prevalent taxa of the fecal microbiota, i.e. Ruminococcaceae, Bacteroidaceae, Lachnospiraceae, Rikenellaceae, and Clostridiaceae, were unaffected by the farm and season. Relative abundance of milk microbiota for Pseudomonadaceae, Enterobacteriaceae, and Streptococcaceae (F1 > F2) and Lactobacillaceae, Bifidobacteriaceae, and Cellulomonadaceae (F1 < F2) were different between the two farms, and those for Staphylococcaceae, Bacillaceae, Ruminococcaceae, and Veillonellaceae (Nov < Jul) and Methylobacteriaceae and Moraxellaceae (Nov > Jul) were different between the two seasons. The microbiota of bulk tank milk was numerically different from that of individual cow milk. Principal coordinate analysis indicated that the milk microbiota was unrelated to the fecal microbiota. The finding that relative abundance of Pseudomonadaceae and Moraxellaceae appeared greater than those reported for Holstein milk suggested that higher protein and fat content may result in a greater abundance of proteolytic and lipolytic taxa in Jersey cow milk.

    DOI： 10.1111/asj.13441

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  • Cyclic nigerosylnigerose ameliorates DSS-induced colitis with restoration of goblet cell number and increase in IgA reactivity against gut microbiota in mice. Reviewed

    Takeshi Tsuruta, Emiko Katsumata, Akiko Mizote, Hou Jian Jian, Teresia Aluoch Muhomah, Naoki Nishino

    Bioscience of microbiota, food and health   39 ( 3 )   188 - 196   2020

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    Cyclic nigerosylnigerose (CNN) is a cyclic oligosaccharide. Oral administration of CNN promotes immunoglobulin A (IgA) secretion in the gut. IgA is a major antibody secreted into the gut and plays a crucial role in suppressing gut inflammation due to commensal gut microbiota. To investigate the effect of administration of CNN to promote IgA secretion on gut inflammation, experimental colitis was induced with dextran sulfate sodium (DSS) in Balb/c mice after 6 weeks of CNN pre-feeding. The severity of colitis was evaluated based on a disease activity index (DAI), the gene expression of inflammatory cytokines, and a histological examination. The CNN-treated mice with DSS-induced colitis (CNN-DSS group) showed significantly lower DAI scores and mRNA levels of interleukin-1 compared with the CNN-untreated mice with DSS-induced colitis (DSS group). Histological examination of the colon revealed that the pathological score was significantly lower in the CNN-DSS group compared with the DSS group due to the reduced infiltration of immune cells. The number of goblet cells was significantly higher in the CNN-DSS group compared with the DSS group. The IgA concentration and the ratio of microbiota coated with IgA were evaluated in the cecal content. Although there was no difference in the IgA concentration among groups, a higher proportion of cecal microbiota were coated with IgA in the CNN-DSS group compared with that in the DSS group. These results suggest that CNN might preserve goblet cells in the colon and promote IgA coating of gut microbiota, which synergistically ameliorate gut inflammation in mice with DSS-induced colitis.

    DOI： 10.12938/bmfh.2020-012

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  • High-fat diet reduces the level of secretory immunoglobulin A coating of commensal gut microbiota. Reviewed

    Muhomah, T. A, Nishino, N, Katsumata, E, Haoming, W, Tsuruta, T

    Bioscience of microbiota, food and health   18   27   2019

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  • The Relationship between Uterine, Fecal, Bedding, and Airborne Dust Microbiota from Dairy Cows and Their Environment: A Pilot Study. Reviewed

    Nguyen, T. T, Miyake, A, Tran, T, Tsuruta, T, Nishino, N

    9 ( 12 )   1007   2019

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  • Rumen fluid, feces, milk, water, feed, airborne dust, and bedding microbiota in dairy farms managed by automatic milking systems. Reviewed

    Wu, H, Nguyen, Q. D, Tran, T. T, Tang, M. T, Tsuruta, T, Nishino, N

    Animal Science Journal   90 ( 3 )   445 - 452   2019

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  • Dietary soy, meat, and fish proteins modulate the effects of prebiotic raffinose on composition and fermentation of gut microbiota in rats Reviewed

    Gaowa Bai, Takeshi Tsuruta, Naoki Nishino

    International Journal of Food Sciences and Nutrition   69 ( 4 )   480 - 487   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Taylor and Francis Ltd  

    DOI： 10.1080/09637486.2017.1382454

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  • Extra-adrenal glucocorticoids contribute to the postprandial increase of circulating leptin in mice Reviewed

    Yuka Tomabechi, Takeshi Tsuruta, Shinichi Saito, Martin Wabitsch, Kei Sonoyama

    Journal of Cell Communication and Signaling   12 ( 2 )   433 - 439   2018

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s12079-017-0403-9

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    Other Link： http://link.springer.com/content/pdf/10.1007/s12079-017-0403-9.pdf

  • Variability, stability, and resilience of fecal microbiota in dairy cows fed whole crop corn silage Reviewed

    Minh Thuy Tang, Hongyan Han, Zhu Yu, Takeshi Tsuruta, Naoki Nishino

    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   101 ( 16 )   6355 - 6364   2017.8

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    DOI： 10.1007/s00253-017-8348-8

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  • Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro Reviewed

    Ayako Aoki-Yoshida, Shinichi Saito, Takeshi Tsuruta, Arisa Ohsumi, Hinako Tsunoda, Kei Sonoyama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   489 ( 2 )   248 - 254   2017.7

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    DOI： 10.1016/j.bbrc.2017.05.152

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  • Comparative microbiota assessment of wilted Italian ryegrass, whole crop corn, and wilted alfalfa silage using denaturing gradient gel electrophoresis and next-generation sequencing Reviewed

    Kuikui Ni, Tang Thuy Minh, Tran Thi Minh Tu, Takeshi Tsuruta, Huili Pang, Naoki Nishino

    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY   101 ( 4 )   1385 - 1394   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00253-016-7900-2

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  • Diversity of lactic acid bacteria in vegetable-based and meat-based fermented foods produced in the central region of Vietnam Reviewed

    Phan YTN, Tang MT, Tran TMT, Nguyen VH, Nguyen TH, Tsuruta T, Nishino N

    AIMS Microbiology   3 ( 1 )   61 - 70   2017

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  • Dietary Casein and Soy Protein Isolate Modulate the Effects of Raffinose and Fructooligosaccharides on the Composition and Fermentation of Gut Microbiota in Rats Reviewed

    Gaowa Bai, Kuikui Ni, Takeshi Tsuruta, Naoki Nishino

    JOURNAL OF FOOD SCIENCE   81 ( 8 )   H2093 - H2098   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1750-3841.13391

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  • Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium Reviewed

    Takeshi Tsuruta, Shinichi Saito, Yosuke Osaki, Akihiro Hamada, Ayako Aoki-Yoshida, Kei Sonoyama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   474 ( 1 )   161 - 167   2016.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2016.03.165

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  • Non-neuronal, but atropine-sensitive ileal contractile responses to short-chain fatty acids: Age-dependent desensitization and restoration under inflammatory conditions in mice Reviewed

    Masako Yajima, Shunsuke Kimura, Shinichiro Karaki, Junko Nio-Kobayashi, Takeshi Tsuruta, Atsukazu Kuwahara, Takaji Yajima, Toshihiko Iwanaga

    Physiological Reports   4 ( 7 )   1 - 11   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-Blackwell Publishing Ltd  

    DOI： 10.14814/phy2.12759

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  • Orally Administered Salacia reticulata Extract Reduces H1N1 Influenza Clinical Symptoms in Murine Lung Tissues Putatively Due to Enhanced Natural Killer Cell Activity Reviewed

    Gustavo A. Romero-Perez, Masayo Egashira, Yuri Harada, Takeshi Tsuruta, Yuriko Oda, Fumitaka Ueda, Takamitsu Tsukahara, Yasuhiro Tsukamoto, Ryo Inoue

    FRONTIERS IN IMMUNOLOGY   7   1 - 9   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2016.00115

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  • Diversity of the intestinal microbiota differently affects non-neuronal and atropine-sensitive ileal contractile responses to short-chain fatty acids in mice Reviewed

    Masako Yajima, Shin-Ichiro Karaki, Takeshi Tsuruta, Shunsuke Kimura, Junko Nio-Kobayashi, Atsukazu Kuwahara, Takaji Yajima

    BIOMEDICAL RESEARCH-TOKYO   37 ( 5 )   319 - 328   2016

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  • Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes Reviewed

    Rino Ishihara, Yuki Mizuno, Akiho Miwa, Akihiro Hamada, Takeshi Tsuruta, Martin Wabitsch, Kei Sonoyama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   458 ( 2 )   362 - 368   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2015.01.118

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  • Dual labeling with 5-bromo-2 '-deoxyuridine and 5-ethynyl-2 '-deoxyuridine for estimation of cell migration rate in the small intestinal epithelium Reviewed

    Mami Asano, Tatsuro Yamamoto, Takeshi Tsuruta, Naomichi Nishimura, Kei Sonoyama

    DEVELOPMENT GROWTH & DIFFERENTIATION   57 ( 1 )   68 - 73   2015.1

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    DOI： 10.1111/dgd.12191

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  • Adiponectin is partially associated with exosomes in mouse serum Reviewed

    Worrawalan Phoonsawat, Ayako Aoki-Yoshida, Takeshi Tsuruta, Kei Sonoyama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   448 ( 3 )   261 - 266   2014.6

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    DOI： 10.1016/j.bbrc.2014.04.114

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  • The evaluation of secretion volume and immunoglobulin A and G concentrations in sow colostrum from anterior to posterior teats Reviewed

    Shohei Ogawa, Takamitsu Tsukahara, Takeshi Tsuruta, Ryoichiro Nishibayashi, Mie Okutani, Masako Nakatani, Kaya Higashide, Shiori Iida, Nobuo Nakanishi, Kazunari Ushida, Ryo Inoue

    ANIMAL SCIENCE JOURNAL   85 ( 6 )   678 - 682   2014.6

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    DOI： 10.1111/asj.12211

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  • Role of the mannose receptor in phagocytosis of Enterococcus faecalis strain EC-12 by antigen-presenting cells Reviewed

    Takeshi Tsuruta, Ryo Inoue, Takayuki Nagino, Ryoichiro Nishibayashi, Yuko Makioka, Kazunari Ushida

    MICROBIOLOGYOPEN   2 ( 4 )   610 - 617   2013.8

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    DOI： 10.1002/mbo3.99

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  • The preventive effect of Bacillus subtilus strain DB9011 against experimental infection with enterotoxcemic Escherichia coli in weaning piglets Reviewed

    Takamitsu Tsukahara, Takeshi Tsuruta, Nobuo Nakanishi, Chie Hikita, Masami Mochizuki, Keizo Nakayama

    ANIMAL SCIENCE JOURNAL   84 ( 4 )   316 - 321   2013

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    DOI： 10.1111/asj.12003

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  • Oral Administration of EC-12 Increases the Baseline Gene Expression of Antiviral Cytokine Genes, IFN-γ and TNF-α, in Splenocytes and Mesenteric Lymph Node Cells of Weaning Piglets. Reviewed

    Takeshi Tsuruta, Ryo Inoue, Toshiki Tsushima, Takumi Watanabe, Takamitsu Tsukahara, Kazunari Ushida

    Bioscience of microbiota, food and health   32 ( 4 )   123 - 8   2013

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    Weaning piglets are continuously exposed to various viruses. The antiviral effects of lactic acid bacteria (LAB) have been confirmed mainly in humans and mice, while few studies have been conducted in livestock. In this study, we evaluated the effect of oral administration of Enterococcus faecalis strain EC-12 (EC-12) on the gene expressions of antiviral cytokines in weaning piglets. Piglets were allocated to the EC-12-administered group (E group) and the no-treatment control group (C group). The small intestinal tissue, the mesenteric lymph node (MLN) cells and the splenocytes were collected from the piglets. The tissue and cells were co-cultured with a live vaccine of porcine reproductive respiratory syndrome virus, porcine epidemic diarrhea virus or EC-12. After the incubation, the gene expressions of IFN-γ and TNF-α in the tissue and cells were evaluated. The gene expressions of IFN-γ in the MLN cells and TNF-α in the splenocytes were significantly higher in the E group than in the C group. However, the increase in the gene expression of antiviral cytokines was observed independently of the antigen treatments. The results of the present study suggest that oral administration of EC-12 did not increase the response of immune cells to specific viral antigens but increased the baseline gene expression of antiviral cytokines.

    DOI： 10.12938/bmfh.32.123

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  • Commensal bacteria coated by secretory immunoglobulin A and immunoglobulin G in the gastrointestinal tract of pigs and calves. Reviewed International journal

    Takeshi Tsuruta, Ryo Inoue, Takamitsu Tsukahara, Mitsunori Nakamoto, Hiroshi Hara, Kazunari Ushida, Takaji Yajima

    Animal science journal = Nihon chikusan Gakkaiho   83 ( 12 )   799 - 804   2012.12

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    DOI： 10.1111/j.1740-0929.2012.01026.x

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  • The G-protein on cholesterol-rich membrane microdomains mediates mucosal sensing of short-chain fatty acid and secretory response in rat colon Reviewed

    T. Yajima, R. Inoue, M. Yajima, T. Tsuruta, S. Karaki, T. Hira, A. Kuwahara

    ACTA PHYSIOLOGICA   203 ( 3 )   381 - 389   2011.11

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    DOI： 10.1111/j.1748-1716.2011.02331.x

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  • Commensal bacteria coated by secretory immunoglobulin A and immunoglobulin G in the gastro-intestinal tract of pigs and calves. Reviewed

    Tsuruta T, Inoue R, Tsukahara T, Hara H, Yajima T

    Animal Science Journal   83   799 - 804   2011

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  • Development of a Method for the Identification of S-IgA-Coated Bacterial Composition in Mouse and Human Feces Reviewed

    Takeshi Tsuruta, Ryo Inoue, Toshihiko Iwanaga, Hiroshi Hara, Takaji Yajima

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   74 ( 5 )   968 - 973   2010.5

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    DOI： 10.1271/bbb.90801

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  • Long-term oral administration of cows&apos; milk improves insulin sensitivity in rats fed a high-sucrose diet Reviewed

    Megumi Matsumoto, Ryo Inoue, Takeshi Tsuruta, Hiroshi Hara, Takaji Yajima

    BRITISH JOURNAL OF NUTRITION   102 ( 9 )   1324 - 1333   2009.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1017/S0007114509990365

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  • The amount of secreted IgA may not determine the secretory IgA coating ratio of gastrointestinal bacteria Reviewed

    Takeshi Tsuruta, Ryo Inoue, Iyori Nojima, Takamitsu Tsukahara, Hiroshi Hara, Takaji Yajima

    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY   56 ( 2 )   185 - 189   2009.7

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    DOI： 10.1111/j.1574-695X.2009.00568.x

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  • A cell preparation of Enterococcus faecalis strain EC-12 stimulates the luminal immunoglobulin A secretion in juvenile calves Reviewed

    Takeshi Tsuruta, Ryo Inoue, Takamitsu Tsukahara, Noritaka Matsubara, Masayuki Hamasaki, Kazunari Ushida

    ANIMAL SCIENCE JOURNAL   80 ( 2 )   206 - 211   2009.4

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    DOI： 10.1111/j.1740-0929.2008.00621.x

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  • LONG-TERM ORAL FEEDINGS OF COW MILK AND WITH LUTEIN INCREASE THE VOLUNTARY RUNNING DISTANCE IN RAT Reviewed

    Megumi Matsumoto, Masahito Hagio, Takeshi Tsuruta, Ryo Inoue, Hiroshi Hara, Takaji Yajima

    ANNALS OF NUTRITION AND METABOLISM   55   430 - 430   2009

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  • Postnatal changes in the expression of genes for cryptdins 1-6 and the role of luminal bacteria in cryptdin gene expression in mouse small intestine Reviewed

    Ryo Inoue, Takeshi Tsuruta, Iyori Nojima, Keizo Nakayama, Takamitsu Tsukahara, Takaji Yajima

    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY   52 ( 3 )   407 - 416   2008.4

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    DOI： 10.1111/j.1574-695X.2008.00390.x

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MISC

  • トリグリセリド分子種構成の異なる油脂の多量摂取が免疫グロブリンAの腸内細菌への結合に及ぼす影響

    鶴田 剛司, 山口 有紀, 王 天陽, 寺岡 真緒, 宮本 泰成, 吉田 孝, 佐々木 美緒, 西野 直樹

    日本栄養・食糧学会大会講演要旨集   77回   241 - 241   2023.3

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  • A1型およびA2型の牛乳とヨーグルトから調製したカゼインの特性

    白里陽, NUOMIN, 鶴田剛司, 西野直樹

    関西畜産学会報   ( 180 )   2023

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  • 環状糖の鎖長の違いが腸管IgA分泌及び盲腸内容物中の短鎖脂肪酸濃度に及ぼす影響

    宮本 泰成, 西野 直樹, 鶴田 剛司

    日本栄養・食糧学会大会講演要旨集   76回   294 - 294   2022.5

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  • 高ラード食、高オリーブ食、高大豆油食の摂取が腸管免疫グロブリンAの腸内細菌への反応性に及ぼす影響

    寺岡 真緒, 西野 直樹, 鶴田 剛司

    日本栄養・食糧学会大会講演要旨集   76回   200 - 200   2022.5

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  • 環状四糖の摂取が高脂肪食誘導性肥満マウスの腸管IgA分泌および肥満関連の生体異常に及ぼす影響

    鶴田剛司, 佐相晴香, 塩津萌々子, 西野直樹

    日本栄養・食糧学会大会講演要旨集   76th   2022

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  • Effect of lard-, olive oil- and soybean oil-enriched diet on immunoglobulin A coating of gut bacteria

    TERAOKA Mao, NISHINO Naoki, TSURUTA Takeshi

    岡山大学農学部学術報告(Web)   111 ( Supplement )   2022

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  • Effect of cyclic nigerosylnigerose (CNN) on insulin resistance in high-fat diet-induced obese mice

    鶴田剛司, 溝手晶子, 塩津萌々子, 佐相晴香, 西野直樹

    日本農芸化学会大会講演要旨集(Web)   2021   2021

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  • 高脂肪食の摂取にともなう腸管IgAの腸内細菌に対する反応性の低下と肥満病態の関係性

    鶴田剛司, 園山慶, 西野直樹

    日本栄養・食糧学会大会講演要旨集   74th   2020

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  • 腸管免疫(分泌型IgA)と腸内細菌の相互作用に油脂の摂取が及ぼす影響

    鶴田剛司

    日本栄養・食糧学会中国・四国支部大会講演要旨集   53rd (CD-ROM)   2020

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  • 岡山県美作市で捕獲された野生シカの血液性状と腸内細菌叢

    小田沙也可, 鶴田剛司, 西野直樹

    日本草地学会誌   65   2019

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  • 牛乳に含まれる細胞外小胞がヒト大腸がん細胞株の増殖活性に及ぼす影響

    高瀬友里加, 鶴田剛司, 西野直樹

    日本栄養・食糧学会大会講演要旨集   73rd   2019

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  • 牛乳中の細胞外小胞がAOM/DSS大腸がん誘導マウスの腫瘍形成に及ぼす影響

    椛島奈津美, 西野直樹, 鶴田剛司

    日本栄養・食糧学会大会講演要旨集   73rd   2019

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  • 牛乳中の細胞外小胞が食餌誘導性肥満マウスの耐糖能異常に及ぼす影響

    樋本栞, 西野直樹, 鶴田剛司

    日本栄養・食糧学会大会講演要旨集   73rd   2019

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  • シクロニゲロシルニゲロース摂取がDSS腸炎に及ぼす影響

    勝又恵実子, 西野直樹, 中村修治, 角田省二, 鶴田剛司

    日本栄養・食糧学会大会講演要旨集   73rd   2019

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  • Reactivity of secretory immunoglobulin A against gut bacteria is attenuated by high-fat diet consumption

    鶴田剛司, MUHOMAH Teresia Aluoch, 園山慶, 西野直樹

    岡山実験動物研究会報   ( 35 )   2019

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  • 組換え型REG3βの投与は食餌誘導性肥満マウスの末梢組織炎症およびインスリン抵抗性を緩和する

    鶴田剛司, 西野直樹, 園山慶

    日本栄養・食糧学会大会講演要旨集   73rd   2019

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  • 腸内細菌と宿主のクロストークを媒介するエクソソーム

    園山慶, 青木(吉田)綾子, 鶴田剛司

    日本農芸化学会大会講演要旨集(Web)   2019   2019

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  • 牛乳中の細胞外小胞によるヒト大腸がん細胞株Caco-2細胞の増殖抑制作用

    鶴田剛司, 福田久仁香, 樋本栞, 勝又恵実子, 園山慶, 西野直樹

    日本栄養・食糧学会大会講演要旨集   72nd   2018

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  • マクロファージが分泌する細胞外小胞は乳酸菌の抗肥満効果を媒介する

    伊藤洋平, 鶴田剛司, 西野直樹, MUHOMAH Terry, 園山慶

    岡山実験動物研究会報   ( 34 )   2018

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  • 腸内細菌の健康機能を媒介する細胞外小胞

    園山慶, 鶴田剛司, 青木(吉田)綾子

    日本栄養・食糧学会大会講演要旨集   72nd   2018

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  • 乳酸菌を貪食したマクロファージが放出する細胞外小胞の脂肪細胞および骨格筋細胞への取り込み

    鶴田剛司, 伊藤洋平, 西野直樹, MUHOMAH Teresia Aluoch, 勝又恵実子, 園山慶

    岡山実験動物研究会報   ( 34 )   2018

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  • シクロニゲロシルニゲロースの摂取が分泌型免疫グロブリンAの分泌および腸内細菌への反応性に及ぼす影響

    勝又恵実子, 西野直樹, TERESIA Muhomah, 鶴田剛司

    日本栄養・食糧学会大会講演要旨集   72nd   2018

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  • 分泌型免疫グロブリンAの腸内細菌への結合活性は高脂肪食の摂取により弱まる

    MUHOMAH Teresia Aluoch, 西野直樹, 園山慶, 桑高佳穂, 鶴田剛司

    日本栄養・食糧学会中国・四国支部大会講演要旨集   51st   2018

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  • 組換え型REG3βの投与は高脂肪食摂取マウスにおける代謝異常を抑制する

    磯田康太朗, 鶴田剛司, 西野直樹, 園山慶

    日本栄養・食糧学会中国・四国支部大会講演要旨集   51st   2018

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  • REG3βが食餌誘導性肥満およびインスリン抵抗性に及ぼす影響

    磯田康太朗, 鶴田剛司, 西野直樹, 園山慶

    日本栄養・食糧学会大会講演要旨集   72nd   2018

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  • Lactobacillus plantarum No.14株を貪食したマクロファージが放出する細胞外小胞はマウスの内臓脂肪蓄積を抑制する

    伊藤洋平, 鶴田剛司, 西野直樹, 園山慶

    日本栄養・食糧学会中国・四国支部大会講演要旨集   51st   2018

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  • Lactobacillus plantarum No.14株を貪食したマクロファージが放出する細胞外小胞は内臓脂肪組織の脂肪蓄積抑制を媒介する

    伊藤洋平, 鶴田剛司, 西野直樹, 園山慶

    日本栄養・食糧学会大会講演要旨集   72nd   2018

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  • プロバイオティック乳酸菌の健康機能が生体内で伝達されるメカニズムの解明

    鶴田剛司

    東洋食品研究所研究報告書   ( 31 )   2017

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  • プロバイオティクスの健康機能を媒介する循環血中のエクソソーム 腸内細菌叢と宿主の新たなクロストークシステムか?

    園山慶, 青木(吉田)綾子, 鶴田剛司

    化学と生物   56 ( 1 )   2017

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  • Lactobacillus plantarum No.14株を貪食したマクロファージが放出する細胞外小胞は細胞種選択的に細胞の栄養代謝に影響を及ぼす

    鶴田剛司, 伊藤洋平, MUHOMAH Terry, 西野直樹, 園山慶

    日本栄養・食糧学会大会講演要旨集   71st   2017

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  • 牛乳中の細胞外小胞によるヒト大腸癌細胞株Caco-2細胞の増殖抑制作用

    福田久仁香, 西野直樹, 園山慶, 鶴田剛司

    日本栄養・食糧学会中国・四国支部大会講演要旨集   49th   2016

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  • マウスの小腸粘膜上皮におけるペプチドYY産生細胞はセロトニン受容体を発現する

    濱田晃弘, 尾崎洋輔, 斉藤伸一, 鶴田剛司, 青木(吉田)綾子, 園山慶

    日本栄養・食糧学会大会講演要旨集   70th   2016

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  • DGGEおよびNGSによるイタリアンライグラス,アルファルファおよびトウモロコシサイレージの細菌叢解析

    西野直樹, NI Kuikui, YEN Ngoc Phan Thi, BAIYILA Wu, 鶴田剛司

    日本畜産学会大会講演要旨   121st   2016

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  • Lactobacillus plantarum No.14株を貪食したマクロファージが放出する細胞外小胞は白色脂肪細胞の脂肪蓄積を抑制する

    鶴田剛司, 伊藤洋平, 西野直樹, MUHOMAH Terry, 園山慶

    日本栄養・食糧学会中国・四国支部大会講演要旨集   49th   2016

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  • 腸内細菌叢の情報を宿主に伝える血中エキソソームのmiRNA

    園山慶, 鶴田剛司, 青木(吉田)綾子

    日本栄養・食糧学会大会講演要旨集   70th   2016

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  • 短期間の高脂肪食摂取によってマウスの腹腔内脂肪におけるリポ多糖結合タンパクの発現が増加する

    関真実, 三輪秋穂, 鶴田剛司, 園山慶

    日本農芸化学会大会講演要旨集(Web)   2016   2016

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  • Identification of commensal bacteria coated with secretory immunoglobulin A

    鶴田剛司

    岡山大学農学部学術報告(Web)   105   2016

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  • 短鎖脂肪酸がマウス結腸オルガノイドのセロトニンシステムにおよぼす影響

    尾崎洋輔, 斉藤伸一, 濱田晃弘, 鶴田剛司, 園山慶

    日本栄養・食糧学会大会講演要旨集   70th   2016

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  • 短鎖脂肪酸がマウス結腸オルガノイドの腸内分泌細胞分化に及ぼす影響

    尾崎洋輔, 斉藤伸一, 濱田晃弘, 鶴田剛司, 園山慶

    日本農芸化学会大会講演要旨集(Web)   2016   2016

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  • 高アミロース含有トウモロコシ澱粉のメタボリックシンドローム改善機序としての小腸急性期タンパク

    鶴田剛司, 鶴田剛司

    飯島藤十郎記念食品科学振興財団年報   31   2016

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  • 食餌タンパク質およびオリゴ糖による盲腸内短鎖脂肪酸濃度と細菌フローラの変動

    白高娃, 鶴田剛司, 西野直樹

    日本栄養・食糧学会中国・四国支部大会講演要旨集   48th   2015

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  • マウス小腸陰窩オルガノイドにおけるセロトニン自己分泌刺激

    濱田晃弘, 鶴田剛司, 青木(吉田)綾子, 園山慶

    日本農芸化学会大会講演要旨集(Web)   2015   2015

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  • R-spondinおよびNogginの発現細胞株の作成とマウス腸管オルガノイドへの応用

    尾崎洋輔, 鶴田剛司, 斉藤伸一, 園山慶

    日本農芸化学会北海道支部講演会講演要旨   2015   2015

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  • プロバイオティクスの炎症抑制作用を媒介するエキソソーム

    青木(吉田)綾子, 大角有里沙, 鶴田剛司, 園山慶

    日本農芸化学会大会講演要旨集(Web)   2014   2014

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  • 血清エキソソームはフラクトオリゴ糖の炎症抑制作用を媒介するか?

    角田妃菜子, 大角有里沙, 三輪明穂, 青木(吉田)綾子, 鶴田剛司, 園山慶

    日本栄養・食糧学会大会講演要旨集   68th   2014

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  • 消化管内の健康と子牛の下痢症対策 子牛の消化管細菌叢とIgAの関係

    鶴田剛司, 牛田一成

    臨床獣医   31 ( 12 )   2013

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  • 消化管における酪酸の粘液透過性とその影響

    塚原隆充, 塚原隆充, 鶴田剛司, 鶴田剛司, 松川典子, 牛田一成, 落合邦康

    日本栄養・食糧学会大会講演要旨集   66th   2012

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  • 腸内細菌叢調節を介したサラシア属植物エキスのインフルエンザ症状軽減作用

    植田文教, 小田由里子, 鶴田剛司, 柿沼千早, 井上亮, 牛田一成, 塚本康浩

    日本食品科学工学会大会講演集   59th   2012

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  • ブタ及びウシの各消化管部位に存在するS-IgA及びIgGに被覆された細菌

    鶴田剛司, 井上亮, 塚原隆允, 中本光則, 原博, 矢島高二, 牛田一成

    日本畜産学会大会講演要旨   114th   2011

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  • 短鎖脂肪酸が腸上皮杯細胞の表面糖鎖に及ぼす影響

    野島伊世里, 井上亮, 鶴田剛司, 原博, 矢島高二

    日本農芸化学会大会講演要旨集   2009   2009

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  • 様々な動物種の各腸管部位に存在するS-IgAコートされた腸内細菌

    鶴田剛司, 井上亮, 野島伊世里, 塚原隆充, 中本光則, 原博, 矢島高二

    日本農芸化学会大会講演要旨集   2008   2008

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Industrial property rights

  • 乳酸菌を利用した体内消化酵素活性化剤

    鶴田 剛司, 渡邉 卓巳, 生天目 由里子

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    Applicant：有限会社バイオ研

    Application no：特願2022-155441  Date applied：2022.9.28

    Announcement no：特開2023-051847  Date announced：2023.4.11

    J-GLOBAL

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Research Projects

  • Influence of dietary long-chain fatty acid on immunoglobulin A coating of commensal gut bacteria

    Grant number：23K10959  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    鶴田 剛司

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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  • 腸管IgAと腸内細菌の結合弱化の予防を基軸としたインスリン抵抗性の制御戦略

    Grant number：20K11580  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    鶴田 剛司

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

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  • New strategies for controlling silage microbiota using integrated analysis of bacteriome and mycobiome

    Grant number：19H03106  2019.04 - 2023.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    西野 直樹, 鶴田 剛司

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    Grant amount：\17290000 （ Direct expense: \13300000 、 Indirect expense：\3990000 ）

    暖地型牧草、食品副産物および混合飼料（TMR）を対象とし、実験室規模でサイレージを調製した。貯蔵温度を3水準（10℃、25℃、40℃）設定し、1週間、2週間、2ヶ月および6ヶ月後に開封して、発酵生成物、好気的安定性および微生物叢を調査した。冷涼（10℃）および暑熱（40℃）環境での貯蔵が、貯蔵性と好気的安定性をどれほど変動させるかを課題とした。細菌叢のアンプリコン解析は16S rRNA遺伝子のV4領域を、真菌叢のそれは26S rRNA遺伝子のITS領域を対象として行っている。
    微生物叢解析まで終了したのは、食品副産物のサイレージである。Acinetobacter spp.がLactobacillus spp.より優勢でありながら、乳酸優勢の発酵特性を示すという興味深い知見が得られるとともに、貯蔵期間が長くなるとBacillus spp.が増加して乳酸生成を維持するという新規性に富む知見も得られた。一方、真菌叢は貯蔵性および好気的安定性と関連する変化を示しておらず、細菌叢と真菌叢のネットワーク解析も今後の課題である。暖地型牧草サイレージは酢酸優勢の発酵特性を示すことが多いが、それが十分再現されたサンプルが得られており、現在細菌叢および真菌叢のアンプリコン解析を進めている。これらのサイレージから培養法による有用乳酸菌の分離および選抜も進めており、意図的に変敗させたサンプルから酵母およびカビの分離も行っている。実規模サイレージのサンプリングも行っており、それらの微生物叢解析も予定通り進めている。

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  • 大腸上皮がん細胞の増殖を抑制する牛乳中の細胞外小胞の解析

    2017 - 2019

    文部科学省  科学研究費補助金（若手研究B） 

    鶴田 剛司

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    Authorship：Principal investigator  Grant type：Competitive

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  • プロバイオティクスの刺激情報を伝達する貪食細胞エキソソームの解析

    2015 - 2016

    文部科学省  科学研究費補助金（若手研究B） 

    鶴田 剛司

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    Authorship：Principal investigator  Grant type：Competitive

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