Updated on 2025/07/03

写真a

 
YAMADA Hiroshi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
External link

Degree

  • 博士(理学) ( 1997.3   広島大学 )

Research Interests

  • クライオ電子顕微鏡

  • microvesicleを介した内在性内分泌制御

  • cytoskeleton

  • cell biology

  • biochemistry

  • biophysics

  • membrane traffic

  • 腎臓の血液濾過の分子生理

  • マラリア原虫の細胞生理

  • がん細胞の遊走、浸潤

Research Areas

  • Life Science / Physiology

  • Life Science / Structural biochemistry  / 電子顕微鏡学

  • Life Science / Functional biochemistry

  • Life Science / Cell biology

  • Life Science / Parasitology

Education

  • Hiroshima University   理学研究科   遺伝子科学専攻

    1995 - 1997

      More details

  • 大阪大学大学院   工学研究科博士前期課程   醗酵工学専攻

    1991 - 1993

      More details

  • Osaka University   工学部   醗酵工学科

    1987 - 1991

      More details

Research History

  • Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University   Department of Biochemistry   Research Professor

    2023.6

      More details

  • Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University   Department of Biochemistry   Associate Professor

    2011.4

      More details

  • 岡山大学大学院医歯薬学総合研究科・講師

    2005.9 - 2011.3

      More details

  • 岡山大学大学院医歯薬学総合研究科・助手(配置換)

    2005.4 - 2005.8

      More details

  • 米国イェール大学医学部細胞生物学講座 (Pietro DeCamilli教授) 客員研究員

    2002.10 - 2003.3

      More details

▼display all

Professional Memberships

 

Papers

  • Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. Reviewed International coauthorship International journal

    The Mon La, Hiromi Tachibana, Shun-Ai Li, Tadashi Abe, Sayaka Seiriki, Hikaru Nagaoka, Eizo Takashima, Tetsuya Takeda, Daisuke Ogawa, Shin-Ichi Makino, Katsuhiko Asanuma, Masami Watanabe, Xuefei Tian, Shuta Ishibe, Ayuko Sakane, Takuya Sasaki, Jun Wada, Kohji Takei, Hiroshi Yamada

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology   34 ( 12 )   16449 - 16463   2020.12

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Dynamin 1 is a neuronal endocytic protein that participates in vesicle formation by scission of invaginated membranes. Dynamin 1 is also expressed in the kidney; however, its physiological significance to this organ remains unknown. Here, we show that dynamin 1 is crucial for microtubule organization and stabilization in glomerular podocytes. By immunofluorescence and immunoelectron microscopy, dynamin 1 was concentrated at microtubules at primary processes in rat podocytes. By immunofluorescence of differentiated mouse podocytes (MPCs), dynamin 1 was often colocalized with microtubule bundles, which radially arranged toward periphery of expanded podocyte. In dynamin 1-depleted MPCs by RNAi, α-tubulin showed a dispersed linear filament-like localization, and microtubule bundles were rarely observed. Furthermore, dynamin 1 depletion resulted in the formation of discontinuous, short acetylated α-tubulin fragments, and the decrease of microtubule-rich protrusions. Dynamins 1 and 2 double-knockout podocytes showed dispersed acetylated α-tubulin and rare protrusions. In vitro, dynamin 1 polymerized around microtubules and cross-linked them into bundles, and increased their resistance to the disassembly-inducing reagents Ca2+ and podophyllotoxin. In addition, overexpression and depletion of dynamin 1 in MPCs increased and decreased the nocodazole resistance of microtubules, respectively. These results suggest that dynamin 1 supports the microtubule bundle formation and participates in the stabilization of microtubules.

    DOI: 10.1096/fj.202001240RR

    PubMed

    researchmap

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.202001240RR

  • Vesicular Glutamate Transporter 3 Is Involved in Glutamatergic Signalling in Podocytes Reviewed

    Naoko Nishii, Tomoko Kawai, Hiroki Yasuoka, Tadashi Abe, Nanami Tatsumi, Yuika Harada, Takaaki Miyaji, Shunai Li, Moemi Tsukano, Masami Watanabe, Daisuke Ogawa, Jun Wada, Kohji Takei, Hiroshi Yamada

    International Journal of Molecular Sciences   26 ( 6 )   2025.3

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    researchmap

  • Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes Reviewed

    Takashi Ohtsuki, Ikumi Sato, Ren Takashita, Shintaro Kodama, Kentaro Ikemura, Gabriel Opoku, Shogo Watanabe, Takayuki Furumatsu, Hiroshi Yamada, Mitsuru Ando, Kazunari Akiyoshi, Keiichiro Nishida, Satoshi Hirohata

    International Journal of Molecular Sciences   25   11942   2024.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms252211942

    researchmap

  • Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. Reviewed

    Yamada, H, Osaka, H, Tatsumi, N, Araki, M, Abe, T, Kaihara, K, Takahashi, K, Takashima, E, Uchihashi, T, Naruse, K, Takei, K

    Cells   13   1373   2024.8

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cells13161373

    researchmap

  • The microtubule-dynamin binding inhibitor peptide PHDP5 rescues spatial learning and memory deficits in Alzheimer’s disease model mice Reviewed

    Chia-Jung Chang, Zacharie Taoufiq, Hiroshi Yamada, Kohji Takei, Takami Tomiyama, Tomohiro Umeda, Tetsuya Hori, Tomoyuki Takahashi

    Brain Research   148987 - 148987   2024.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.brainres.2024.148987

    researchmap

▼display all

MISC

  • オートファジー Invited

    竹居孝二, 山田浩司

    岡山医学会雑誌   135   92 - 94   2023.8

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    researchmap

  • Dynamic interaction of amphiphysin with N-WASP regulates actin assembly Invited

    山田浩司, PADILLA-PARRA Sergi, 朴宣奏, 伊藤俊樹, CHAINEAU Mathilde, MONALDI Ilaria, CREMONA Ottavio, BENFENATI Fabio, De CAMILLI, COPPEY-MOISAN Maïté, TRAMIER Marc, GALLI Thierry, 竹居孝二

    岡山医学会雑誌   123 ( 1 )   1 - 11   2011

     More details

    Authorship:Lead author   Language:Japanese  

    J-GLOBAL

    researchmap

  • シナプスの可塑性とグルタミン酸受容体のクラスリン被覆小胞による細胞内への取り込み Invited Reviewed

    山田浩司

    化学と工業   54 ( 6 )   2001

     More details

    Authorship:Lead author, Last author, Corresponding author   Language:Japanese  

    J-GLOBAL

    researchmap

Presentations

  • 糸球体足細胞(ポドサイト)におけるダイナミンによる微小管制御と形態形成 Invited

    山田 浩司

    第94回日本生化学会大会  2021.11.3 

     More details

    Event date: 2021.11.3 - 2021.11.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    researchmap

  • ダイナミンによる細胞骨格制御 Invited

    山田 浩司

    愛媛大学応用化学セミナー・ミニシンポジウム  2021.7.21 

     More details

    Event date: 2021.7.21

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    researchmap

  • 血液ろ過に重要な新規の腎臓病治療標的タンパク質「ダイナミン1」の発見 Invited

    山田浩司

    未来のバイオ技術勉強会  2021.4.23  バイオインダストリー協会

     More details

    Event date: 2021.4.23

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  • シナプトポディン2様タンパク質とアルファーアクチニンとの直接結合は心筋細胞のアクチン線維束形成に寄与する

    山田 浩司, 大坂 紘奈, 辰巳 七海, 荒木 美羽, 阿部 匡史, 貝原 恵子, 高橋 賢, 高島 英造, 内橋 貴之, 成瀬 恵治, 竹居 孝二

    第97回日本生化学会大会  2024.11.7 

     More details

    Event date: 2024.11.6 - 2024.11.8

    Language:Japanese   Presentation type:Poster presentation  

    researchmap

  • 骨芽細胞移動を制御するアクチンフィラメント形成におけるダイナミンの役割

    守谷拓巳, A SURONG, 山田浩司, 竹居孝二, 上岡寛, 岡村裕彦, 池亀美華

    日本解剖学会第78回中国・四国支部学術集会  2024.10.20 

     More details

    Event date: 2024.10.19 - 2024.10.20

    Language:Japanese   Presentation type:Oral presentation (general)  

    researchmap

▼display all

Industrial property rights

  • アルツハイマー病治療薬

    高橋智幸, Zacharie Taoufiq, 堀哲也, 竹居孝二, 山田浩司

     More details

    Application no:特願2022-145546  Date applied:2022.9.23

    researchmap

  • 抗がん剤

    道上 宏之, 松井 秀樹, 林 桂一郎, 竹居 孝二, 山田 浩司, 宮地 弘幸, 浅井 章良

     More details

    Applicant:国立大学法人 岡山大学

    Application no:特願2012-263317  Date applied:2012.11.30

    Announcement no:特開2014-108930  Date announced:2014.6.12

    Patent/Registration no:特許第5922563号  Date issued:2016.4.22

    J-GLOBAL

    researchmap

  • 抗浸潤薬の新規スクリーニング法

    山田 浩司, 道上 宏之, 竹居 孝二, 松井 秀樹, 浅井 章良

     More details

    Applicant:国立大学法人 岡山大学

    Application no:特願2012-137489  Date applied:2012.6.19

    Announcement no:特開2014-002043  Date announced:2014.1.9

    Patent/Registration no:特許第5806168号  Date issued:2015.9.11

    J-GLOBAL

    researchmap

  • 医薬組成物

    竹居 孝二, 李 順愛, 山田 浩司, 公文 裕巳, 那須 保友, 渡部 昌実

     More details

    Applicant:国立大学法人 岡山大学

    Application no:特願2008-114729  Date applied:2008.4.25

    Announcement no:特開2009-057364  Date announced:2009.3.19

    Patent/Registration no:特許第5283962号  Date issued:2013.6.7

    J-GLOBAL

    researchmap

Awards

  • 教育奨励賞

    2011   岡山医学会  

    山田 浩司

     More details

  • 脳神経研究奨励賞

    2009   岡山医学会  

    山田 浩司

     More details

Research Projects

  • 新規細胞分裂必須分子を標的とする革新的抗マラリア薬の開発

    2025.04 - 2026.03

    国立研究開発法人 日本医療研究開発機構 「橋渡し研究戦略的推進プログラム」シーズA 

    山田浩司、高島英造、内橋貴之、澤田隆介

      More details

    Authorship:Principal investigator 

    researchmap

  • 熱帯熱マラリア原虫の細胞分裂を司る膜狭窄・分裂機構の解明と新規創薬ターゲットの創生

    2025.01 - 2027.12

    シオノギ感染症研究振興財団  基礎基盤研究助成金 

    山田浩司、高島英造、内橋貴之、澤田隆介

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\30000000 ( Direct expense: \30000000 )

    researchmap

  • 慢性腎臓病克服をめざす糸球体ポドサイトのマルチスケール解析

    2024.06

    岡山県  電源所在県科学技術振興事業 

    山田浩司, 竹居孝二, 田邊克幸, 米澤朋子

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\7498150 ( Direct expense: \6816500 、 Indirect expense:\681650 )

    researchmap

  • 腎臓糸球体ポドサイトの血液濾過機能におけるダイナミン関連タンパクによるアクチン制御の役割

    2024

    愛媛大学プロテオサイエンスセンター 共同利用・共同研究拠点「プロテオインタラクトーム解析共同研究拠点(PRiME)」 

    山田浩司、高島英造

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\250000 ( Direct expense: \250000 )

    researchmap

  • ダイナミン超複合体による新規の細胞骨格リアレンジメント機構

    Grant number:23H02477  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    竹居孝二、山田浩司

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3000000 ( Direct expense: \3000000 )

    researchmap

▼display all

 

Class subject in charge

  • 医学研究インターンシップ (2024academic year) 特別

  • Project-based Learning in Molecular Pathogenesis (2024academic year) special  - その他

  • Biochemistry (2024academic year) special  - その他

  • Biochemistry (2024academic year) Concentration  - その他

  • Practice in Biochemistry (2024academic year) special  - その他

▼display all