研究者詳細 - 丸山　貴之

論文 - 丸山　貴之

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大学病院における口腔ケア岡山大学病院頭頸部がんセンターにおける顎骨再建後のインプラントと口腔ケアの重要性

水川展吉, 武田斉子, 木股敬裕, 松本洋, 安藤瑞生, 丸山貴之, 佐々木禎子, 田中祐貴, 上田明広, 飯田征二

日本口腔ケア学会雑誌 16 ( 3 ) 83 - 83 2022年4月

家庭での毎日の受動喫煙曝露は大学生の歯周病と関係する(横断研究)

江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, 外山直樹, イスラム・モハマド・モニルル, 澤田ななみ, 中原桃子, 中島千穂, 出口純也, 福原瑶子, 森田学

口腔衛生学会雑誌 72 ( 1 ) 54 - 54 2022年1月

岡山大学新入生の口腔健康状態および主観的口腔健康評価の9年間の変化

中原桃子, 外山直樹, 江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, イスラム・モハマド・モニルル, 澤田ななみ, 中島千穂, 出口純也, 森田学

口腔衛生学会雑誌 72 ( 1 ) 54 - 54 2022年1月

Detection of Salivary miRNAs That Predict Chronic Periodontitis Progression: A Cohort Study. 査読国際誌

Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Yoshio Sugiura, Manabu Morita

International journal of environmental research and public health 18 ( 15 ) 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

The aim of this two-year cohort study was to investigate salivary microRNAs (miRNAs) that predict periodontitis progression. A total of 120 patients who underwent supportive periodontal therapy were recruited. Unstimulated whole saliva was collected at baseline. Two years later, 44 patients were followed up (median age, 67.1 years) and divided into two groups: progression group (n = 22), with one or more sites with clinical attachment level (CAL) progression (>3 mm compared with baseline) or tooth extraction due to periodontitis progression; and the control group (n = 22), which did not exhibit CAL progression. In the microarray analysis of salivary miRNAs, hsa-miR-5571-5p, hsa-miR-17-3p, hsa-let-7f-5p, hsa-miR-4724-3p, hsa-miR-99a-5p, hsa-miR-200a-3p, hsa-miR-28-5p, hsa-miR-320d, and hsa-miR-31-5p showed fold change values <0.5 or ≥2.0 in the progression group compared with the control group (p < 0.05). On receiver operating characteristic curve analysis, areas under the curves of hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were >0.7, indicating fair discrimination power. The expressions of salivary hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. These salivary miRNAs may be new biomarkers for progression of periodontitis, and monitoring them may contribute to new diagnostics and precision medicine for periodontitis.

DOI： 10.3390/ijerph18158010

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Parafunctional masseter muscle activity during waking is related to periodontitis progression: A pilot prospective cohort study. 査読国際誌

Daisuke Ekuni, Seiya Kato, Shigehisa Kawakami, Takayuki Maruyama, Kota Kataoka, Yoko Uchida-Fukuhara, Daiki Fukuhara, Naoki Toyama, Aya Yokoi, Md Monirul Islam, Subrina Binta Khair, Naoki Kodama, Manabu Morita

Journal of clinical periodontology 48 ( 6 ) 785 - 794 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

AIM: The purpose of this pilot prospective cohort study was to investigate the effects of parafunctional masseter muscle activity on periodontitis progression among patients receiving supporting periodontal therapy (SPT). MATERIALS AND METHODS: We collected data of patients treated at Okayama University Hospital from August 2014 to September 2018. The progression group was defined as patients with ≥2 teeth demonstrating a longitudinal loss of proximal attachment of ≥3 mm during the 3-year study period and/or at least one tooth extraction due to periodontitis progression. Surface electromyography of masseter muscles at baseline was continuously recorded while patients were awake and asleep. RESULTS: We analysed 48 patients (36 females) aged 66.8 ± 9.1 years (mean ± SD). The rate of parafunctional masseter muscle activity during waking hours and sleeping hours at baseline was 60.4% and 52.1%, respectively. Cox's proportional hazards regression model showed that the incidence of periodontitis progression was significantly associated with number of teeth present (p = 0.001) and parafunctional masseter muscle activity during waking hours (p = 0.041). CONCLUSION: Our results suggest that parafunctional masseter muscle activity during waking hours is a risk factor for periodontitis progression among patients receiving SPT.

DOI： 10.1111/jcpe.13432

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcpe.13432

噛みたばこ習慣のあるミャンマーでの口腔がん検診

水川展吉, Swe Swe Win, 加藤昌, 丸山貴之, 山近英樹, 木股敬裕, 飯田征二

頭頸部癌 47 ( 2 ) 244 - 244 2021年5月

「口臭による日常生活への支障」に関連する要因

佐保輝, 横井彩, 丸山貴之, 竹内倫子, 江國大輔, 森田学

日本口臭学会会誌 12 ( 1 ) 11 - 17 2021年5月

「口臭による日常生活への支障」に関連する要因

佐保輝, 横井彩, 丸山貴之, 竹内倫子, 江國大輔, 森田学

日本口臭学会会誌 12 ( 1 ) 49 - 50 2021年5月

岡山大学病院頭頸部がんセンターにおける頭頸部がん支持療法に関する臨床実習教育の取り組みについて

丸山貴之, 横井彩, 中原桃子, 佐々木禎子, 梶谷明子, 藤代万由, 中本美保, 吉田陽子, 森田学, 三浦留美, 山中玲子, 水川展吉, 浅海淳一, 安藤瑞生, 木股敬裕

日本口腔ケア学会雑誌 15 ( 3 ) 186 - 186 2021年4月

ヘルスリテラシーとリスク選好が定期的な歯科健診への受診意志に与える影響

角田伊知郎, 森田学, 江國大輔, 丸山貴之, 片岡広太, 横井彩, 福原大樹, 福原瑶子, 外山直樹, 中原桃子

口腔衛生学会雑誌 71 ( 増刊 ) 88 - 88 2021年4月

頭頸部がん治療による口腔機能・QOLへの影響縦断研究

横井彩, 丸山貴之, 中原桃子, 山中玲子, 江國大輔, 森田学

口腔衛生学会雑誌 71 ( 増刊 ) 116 - 116 2021年4月

岡山大学病院頭頸部がんセンターにおけるエピシル使用経験について

武田斉子, 水川展吉, 田村庄平, 岡田亜由美, 中田靖章, 横井彩, 丸山貴之, 松崎秀信, 松崎久美子, 藤代万由, 佐々木禎子, 山中玲子, 安藤瑞生, 木股敬裕, 浅海淳一, 飯田征二

日本口腔ケア学会雑誌 15 ( 3 ) 172 - 172 2021年4月

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue 査読

TERUMASA KOBAYASHI, TAKAYUKI MARUYAMA, TOSHIKI YONEDA, HISATAKA MIYAI, TETSUJI AZUMA, TAKAAKI TOMOFUJI, DAISUKE EKUNI, MANABU MORITA

In Vivo 34 ( 2 ) 615 - 622 2020年3月

慢性歯周炎患者の歯周状態の悪化に関連する唾液中miRNAの探索コホート研究

藤森浩平, 米田俊樹, 杉浦嘉雄, 丸山貴之, 江國大輔, 東哲司, 友藤孝明, 森田学

口腔衛生学会雑誌 70 ( 増刊 ) 158 - 158 2020年3月

Detection of Serum miRNAs Affecting Liver Apoptosis in a Periodontitis Rat Model 査読

YOSHIO SUGIURA, TOSHIKI YONEDA, KOHEI FUJIMORI, TAKAYUKI MARUYAMA, HISATAKA MIYAI, TERUMASA KOBAYASHI, DAISUKE EKUNI, TAKAAKI TOMOFUJI, MANABU MORITA

In Vivo 34 ( 1 ) 117 - 123 2020年1月

Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study. 査読国際誌

Aya Yokoi, Daisuke Ekuni, Hironobu Hata, Mayu Yamane-Takeuchi, Takayuki Maruyama, Reiko Yamanaka, Manabu Morita

Journal of applied oral science : revista FOB 27 e20180635 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. METHODOLOGY: Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). RESULTS: Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). CONCLUSION: Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.

DOI： 10.1590/1678-7757-2018-0635

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Serum microRNAs and chronic periodontitis: A case-control study. 査読国際誌

Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Kohei Fujimori, Yoshio Sugiura, Manabu Morita

Archives of oral biology 101 57 - 63 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: An association is present between periodontitis and rates of expression of certain microRNAs (miRNAs) in periodontal tissue. However, the association between periodontitis and miRNA levels in human serum is unknown. We performed a case-control study in patients with chronic periodontitis to investigate serum miRNA levels. DESIGN: We enrolled 30 healthy patients without periodontitis and 30 patients with chronic periodontitis. Participants underwent clinical examination, case selection, and a blood draw from the antecubital vein. Serum miRNA profiles were compared in samples from participants with and without chronic periodontitis using microarray and real-time PCR. RESULTS: Microarray demonstrated seven miRNAs that were expressed <1/1.5 or >1.5 in the control group compared to the periodontitis group (p < 0.05). Real-time PCR showed that hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p were higher in the periodontitis group than the control group (p < 0.05). CONCLUSION: Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are candidate serum biomarkers for chronic periodontitis.

DOI： 10.1016/j.archoralbio.2019.03.009

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Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. 査読国際誌

Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Hirofumi Mizuno, Yoshio Sugiura, Manabu Morita

Molecules (Basel, Switzerland) 24 ( 6 ) 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

DOI： 10.3390/molecules24061034

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Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study. 査読

Mizuno H, Miyai H, Yokoi A, Kobayashi T, Inabu C, Maruyama T, Ekuni D, Mizukawa N, Kariya S, Nishizaki K, Kimata Y, Morita M

In vivo (Athens, Greece) 33 ( 1 ) 183 - 189 2019年1月

New oral hygiene care regimen reduces postoperative oral bacteria count and number of days with elevated fever in ICU patients with esophageal cancer. 査読

Hirofumi Mizuno, Shinsuke Mizutani, Daisuke Ekuni, Ayano Tabata-Taniguchi, Takayuki Maruyama, Aya Yokoi, Chie Omori, Kazuyoshi Shimizu, Hiroshi Morimatsu, Yasuhiro Shirakawa, Manabu Morita

Journal of oral science 60 ( 4 ) 536 - 543 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

DOI： 10.2334/josnusd.17-0381

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