研究者詳細 - 丸山　貴之

論文 - 丸山　貴之

分割表示 >> ／全件表示 67 件中 1 - 67 件目

Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial. 国際誌

Hisataka Miyai, Takaaki Tomofuji, Hirofumi Mizuno, Manabu Morita, Momoko Nakahara, Kota Kataoka, Ichiro Sumita, Yurika Uchida, Naoki Toyama, Aya Yokoi, Reiko Yamanaka-Kohno, Noriko Takeuchi, Takayuki Maruyama, Daisuke Ekuni

Healthcare (Basel, Switzerland) 13 ( 6 ) 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study was to investigate the effect of trehalose on halitosis. Methods: This prospective, double-blinded, placebo-controlled, cross-over study enrolled volunteers from Okayama University Hospital. The participants were randomly divided into two groups, with one group receiving trehalose (a 10% trehalose solution) and the other receiving a placebo (distilled water) in a 1:1 allocation. The primary study outcome was the subjective organoleptic test. The secondary outcomes were the concentrations of the VSCs, which were measured using a portable gas chromatography device, and the oral moisture status, which was measured using an oral moisture meter. The planned sample size was 10 participants based on the previous study. Results: The final intention-to-treat analysis was performed using the data from 9 participants. After applying 10% trehalose as an oral spray, the organoleptic score decreased in a time-dependent manner. However, no significant differences were seen between the trehalose and placebo groups. In terms of secondary outcomes, the oral moisture levels increased immediately after the trehalose spray application, and significant differences in the amount of change from the baseline were seen between the trehalose and placebo groups (p = 0.047). No significant differences were seen in any of the other variables (p > 0.05). Conclusions: We could not identify any positive effects on halitosis from a one-time 10% trehalose application as an oral spray in this prospective, double-blinded, placebo-controlled, cross-over study. However, the trehalose application immediately improved the oral moisture levels and was useful for treating oral dryness.

DOI： 10.3390/healthcare13060619

PubMed

researchmap

Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial. 国際誌

Takayuki Maruyama, Eiji Takayama, Shinichi Tokuno, Manabu Morita, Daisuke Ekuni

Healthcare (Basel, Switzerland) 13 ( 5 ) 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background/Objectives: Initiation and progression of periodontal disease include oxidative stress. Systemic application of antioxidants may provide clinical benefits against periodontal disease including gingivitis. Recently, a jelly containing a high concentration of hydrogen (40 ppm) was developed. We hypothesized that oral intake of this hydrogen-rich jelly may be safe and effective on gingivitis. This clinical trial was designed to investigate the safety and efficacy of oral intake of hydrogen-rich jelly against gingival inflammation. Methods: Participants with gingivitis were instructed to orally ingest 30 g of hydrogen-rich jelly (experimental group) or placebo jelly (control group) three times a day for 14 consecutive days. The primary outcome of this trial was the percentage of bleeding on probing (BOP) sites. Secondary outcomes were oral parameters, serum reactive oxygen metabolites, antioxidant capacity, oxidative index, concentrations of cytokine (interleukin [IL]-1β, IL-6, IL-10, IL-17, and tumor necrosis factor-alpha) in gingival crevicular fluid, and adverse events. For all parameters, Mann-Whitney U test was used for comparison between experimental and control groups. Analysis of covariance, controlling for baseline periodontal inflamed surface area, was performed to evaluate the association between the effect of the hydrogen-rich jelly and gingival inflammation. Results: In the experiment and control groups, the percentage of sites with BOP and PISA significantly decreased at the end of the experiment compared to the baseline. However, no significant differences were found between groups (p > 0.05). Conclusions: Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. However, no significant differences were identified compared to the control group.

DOI： 10.3390/healthcare13050577

PubMed

researchmap

Relationship among cancer treatment, quality of life, and oral function in head and neck cancer survivors: A cross-sectional study. 査読国際誌

Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Noriko Takeuchi, Manabu Morita, Daisuke Ekuni

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 32 ( 12 ) 809 - 809 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: Treatment for head and neck cancer (HNC), such as surgery and chemoradiotherapy, can reduce oral function and affect quality of life (QoL). However, whether HNC treatment affects QoL via the decline of oral function remains unclear. This study aimed to investigate the relationship among cancer treatment, QoL, and actual oral function in HNC survivors. METHODS: A total of 100 HNC survivors who had completed definitive treatment for HNC at least 6 months prior to enrollment were enrolled in this cross-sectional study. QoL was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 summary score. Oral diadochokinesis (ODK), tongue pressure, moisture level on the mucosal surface, and mouth opening were measured. Information on age, sex, tumor site, tumor stage, history of HNC treatment, height, body weight, and lifestyle were collected from medical records. Structural equation modeling (SEM) was conducted to analyze the indirect/direct associations among HNC treatment, QoL, and oral function. RESULTS: In total, 100 HNC survivors (58 males and 42 females; age range, 30-81 years, median, 67 years) were analyzed. Overall, 63 patients (63.0%) were diagnosed as oral cancer, 66 (66.0%) developed advanced cancer (stage 3/4), and 58 (58.0%) underwent reconstruction surgery in 100 HNC survivors. The SEM results supported the hypothesized structural model (root mean square error of approximation = 0.044, comparative fit index = 0.990, Tucker-Lewis index = 0.986). Surgery with neck dissection and reconstruction for advanced cancer had indirect effects on lower QoL via ODK and mouth opening. CONCLUSION: HNC treatment is indirectly associated with QoL via oral function in HNC survivors.

DOI： 10.1007/s00520-024-09015-y

PubMed

researchmap

Perioperative gum-chewing training prevents a decrease in tongue pressure after esophagectomy in thoracic esophageal cancer patients: a nonrandomized trial 査読

Reiko Yamanaka-Kohno, Yasuhiro Shirakawa, Aya Yokoi, Naoaki Maeda, Shunsuke Tanabe, Kazuhiro Noma, Kazuyoshi Shimizu, Toshiharu Mituhashi, Yoshihide Nakamura, Souto Nanba, Yurika Uchida, Takayuki Maruyama, Manabu Morita, Daisuke Ekuni

Scientific Reports 14 ( 1 ) 2024年10月

掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Tongue pressure (TP) decreases significantly after esophagectomy in esophageal cancer patients (ECPs). Meanwhile, 2 weeks of gum-chewing training (GCT) significantly increased TP in healthy university students. We examined whether perioperative GCT would decrease the proportion of patients exhibiting a decline in TP at 2 weeks postoperatively, and prevent postoperative complications, in thoracic ECPs (TECPs). This was a single-center interventional study, and nonrandomized study with a historical control group (HCG). TECPs who underwent first-stage radical esophagectomy were recruited. Thirty-two patients of 40 in the gum-chewing group (GCG) were completed perioperative GCT in 3 times daily. Propensity score matching was performed with covariates related to TP including preoperative age, sex, body mass index, and the repetitive saliva swallowing test result, and yielded a matched cohort of 25 case pairs. Eleven GCG patients [44.0%] exhibited significantly lower TP at 2 weeks postoperatively than before esophagectomy was significantly fewer than that of 19 patients [76.0%] in the HCG. The median number of fever days (> 38 °C) in the 2 weeks after esophagectomy in the GCG was significantly fewer than those in the HCG. Perioperative GCT may prevent postoperative TP decline and postoperative dysphagia-related complications after esophagectomy.

DOI： 10.1038/s41598-024-74090-4

researchmap

その他リンク： https://www.nature.com/articles/s41598-024-74090-4

口腔内のPorphyromonas gingivalis菌数と血清中抗ジンジパイン抗体価の関連性

中村彪雅, 下津尭子, 安居良太, 大廣義幸, 安田多賀子, 丸山貴之, 畑中加珠, 江國大輔, 高柴正悟

臨床化学 53 ( Suppl.1 ) 211 - 211 2024年7月

Effect of Antimicrobial Photodynamic Therapy on the Tongue Dorsum on Reducing Halitosis and the Duration of the Effect: A Randomized Clinical Trial. 査読国際誌

Takayuki Maruyama, Daisuke Ekuni, Aya Yokoi, Junichiro Nagasaki, Nanami Sawada, Manabu Morita

Healthcare (Basel, Switzerland) 12 ( 10 ) 2024年5月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on the tongue dorsum on reducing oral halitosis and the duration of the effect. This study was approved by the Ethics Committee of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Okayama University Hospital (CRB20-015), and it was registered in the Japan Registry of Clinical Trials (jRCTs061200060). Twenty-two participants were randomly assigned to two groups: an intervention group and control group. PDT was performed in the intervention group using red laser emission and methylene blue gel on the middle and posterior area of the tongue dorsum. The concentration of volatile sulfur compounds, bacterial count on the tongue dorsum, probing pocket depth, bleeding on probing, and simplified oral debris index score were determined before and 1 week after PDT. The Mann-Whitney U test was used to assess the significance of the differences in each parameter between the two groups. We found that the hydrogen sulfide concentration and bacterial count on the tongue dorsum were decreased in the intervention group, but there was no statistically significant difference between the two groups. These results indicated that performing only PDT on the tongue dorsum may not contribute to reducing halitosis.

DOI： 10.3390/healthcare12100980

PubMed

researchmap

歯周状態と唾液エクソソーム中miRNAとの関係横断研究

澤田ななみ, 福原大樹, 角田伊知郎, 中原桃子, 外山直樹, 横井彩, 竹内倫子, 丸山貴之, 江國大輔

口腔衛生学会雑誌 74 ( 増刊 ) 141 - 141 2024年4月

マウスモデルにおける歯周病と糖尿病がアルツハイマー病に与える影響

中原桃子, 福原大樹, Mohammad Nurhamim, Zhang Yixuan, 丸山貴之, 江國大輔

口腔衛生学会雑誌 74 ( 増刊 ) 153 - 153 2024年4月

サルコペニアと口腔機能との関連(横断研究)

稲田さくら, 竹内倫子, 澤田ななみ, 外山直樹, 横井彩, 丸山貴之, 角田伊知郎, 福原大樹, 森田学, 江國大輔

口腔衛生学会雑誌 74 ( 1 ) 60 - 60 2024年1月

Effects of Bacillus subtilis on periodontitis in a mouse model(タイトル和訳中)

Zhang Yixuan, Mohammad Nurhamim, 中原桃子, 福原大樹, 丸山貴之, 江國大輔

岡山歯学会雑誌 42 ( 2 ) 76 - 76 2023年12月

口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

武田斉子, 有村友紀, 田村庄平, 中辻和樹, 三上彩可, 松崎秀信, 丸山貴之, 横井彩, 天野克比古, 水川展吉, 飯田征二

日本口腔ケア学会雑誌 17 ( 3 ) 242 - 242 2023年4月

大学生における歯周病発症と受動喫煙を含む危険因子との関係コホート研究

内田悠理香, 江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, 福原瑶子, 外山直樹, 澤田ななみ, 中島千穂, 中原桃子, 角田伊知郎, 森田学

口腔衛生学会雑誌 73 ( 増刊 ) 149 - 149 2023年4月

大学生における主観的口腔健康評価の傾向と,口腔健康状態および口腔保健行動との関連性

中原桃子, 外山直樹, 江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, 澤田ななみ, 中島千穂, 森田学

岡山歯学会雑誌 41 ( 2 ) 61 - 61 2022年12月

The Impact of Oral Health Behaviors, Health Belief Model, and Absolute Risk Aversion on the Willingness of Japanese University Students to Undergo Regular Dental Check-Ups: A Cross-Sectional Study 査読国際誌

Ichiro Sumita, Naoki Toyama, Daisuke Ekuni, Takayuki Maruyama, Aya Yokoi, Daiki Fukuhara, Yoko Uchida-Fukuhara, Momoko Nakahara, Manabu Morita

International Journal of Environmental Research and Public Health 19 ( 21 ) 13920 - 13920 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Oral health behaviors, risk aversion, and the health belief model are associated with health behaviors. However, there have been few studies that investigated the association between these factors and the willingness to undergo regular dental check-ups. The purpose of this cross-sectional study was to investigate the associations between the willingness of Japanese university students to undergo regular dental check-ups and oral health behaviors, the health belief model, and absolute risk aversion. An analysis was conducted with the cooperation of questionnaire respondents (n = 748) who underwent dental check-ups at Okayama University. The students answered questionnaires on oral health behaviors, the health belief model, absolute risk aversion, and willingness to undergo regular dental check-ups. The logistic regression analysis showed significant positive associations (p < 0.05) between oral health behaviors (use of the inter-dental brush and the dental floss) and the health belief model with the willingness to undergo regular dental check-ups. However, there was no significant association with absolute risk aversion (p > 0.05). These results suggest that willingness to undergo regular dental check-ups was associated with oral health behaviors and the health belief model, but not with absolute risk aversion.

DOI： 10.3390/ijerph192113920

PubMed

researchmap

Trends in Self-Rated Oral Health and Its Associations with Oral Health Status and Oral Health Behaviors in Japanese University Students: A Cross-Sectional Study from 2011 to 2019. 査読国際誌

Momoko Nakahara, Naoki Toyama, Daisuke Ekuni, Noriko Takeuchi, Takayuki Maruyama, Aya Yokoi, Daiki Fukuhara, Nanami Sawada, Yukiho Nakashima, Manabu Morita

International journal of environmental research and public health 19 ( 20 ) 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Self-rated oral health (SROH) is a valid, comprehensive indicator of oral health status. The purpose of this cross-sectional study was to analyze how oral health behaviors and clinical oral status were associated with SROH and how they had changed over the course of nine years in Japanese university students. Data were obtained from 17,996 students who underwent oral examinations and completed self-questionnaires from 2011 to 2019. Oral status was assessed using the decayed and filled teeth scores, bleeding on probing (BOP), probing pocket depth, the Oral Hygiene Index-Simplified (OHI-S), oral health behaviors, and related factors. SROH improved from 2011 to 2019. The logistic regression model showed that university students who were female and had a high daily frequency of tooth brushing, no BOP, no decayed teeth, no filled teeth, and a low OHI-S score and were significantly more likely to report very good, good, or fair SROH. An interaction effect was observed between survey year and regular dental check-ups (year × regular dental check-ups). The improvement trend in SROH might be associated with changes in oral health behaviors and oral health status.

DOI： 10.3390/ijerph192013580

PubMed

researchmap

Relationship between Psychological Stress Determined by Voice Analysis and Periodontal Status: A Cohort Study. 査読国際誌

Takayuki Maruyama, Daisuke Ekuni, Masakazu Higuchi, Eiji Takayama, Shinichi Tokuno, Manabu Morita

International journal of environmental research and public health 19 ( 15 ) 2022年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

In modern society, evaluation and management of psychological stress may be important for the prevention of periodontal disease. The purpose of this study was to examine the relationship between psychological stress (vitality and mental activity) evaluated by Mind Monitoring System (MIMOSYS) and periodontal status. Forty students of Okayama University underwent the oral examination and self-reported questionnaire on the first day (baseline) and the 14th day (follow-up). Voice recording was performed every day with the MIMOSYS app during the whole study period. The participants completed the Patient Health Questionnaire (PHQ)-9 and Beck Depression Inventory (BDI) at baseline and at follow-up. Spearman's rank correlation coefficient was used to determine the significance of correlations among variables. The PHQ-9 and BDI scores were negatively correlated with vitality in the morning. Change in vitality in the morning was significantly correlated with changes in periodontal inflammation. Mental activity was significantly correlated with change in mean probing pocket depth. This result shows that measurement of psychological stress using a voice-based tool to assess mental health may contribute to the early detection of periodontal disease.

DOI： 10.3390/ijerph19159489

PubMed

researchmap

Association between serum miRNAs and gingival gene expression in an obese rat model 査読

Takayuki Maruyama, Terumasa Kobayashi, Yoshio Sugiura, Toshiki Yoneda, Daisuke Ekuni, Manabu Morita

Journal of Periodontal Research 57 ( 3 ) 502 - 509 2022年6月

舌背への光線力学療法による口臭の改善効果の検討ランダム化比較試験

長崎潤一郎, 丸山貴之, 横井彩, 江國大輔, 澤田ななみ, 森田学

口腔衛生学会雑誌 72 ( 増刊 ) 81 - 81 2022年4月

コロナ禍前とコロナ禍における大学生の睡眠時ブラキシズムの検討(横断研究)

江國大輔, 丸山貴之, 横井彩, 福原大樹, 外山直樹, 澤田ななみ, 中原桃子, 角田伊知郎, 森田学

口腔衛生学会雑誌 72 ( 増刊 ) 79 - 79 2022年4月

周術期のガム咀嚼トレーニングは胸部食道がん患者の咀嚼能力を維持・向上させる

山中玲子, 白川靖博, 横井彩, 中村吉秀, 難波奏人, 田辺俊介, 野間和広, 清水一好, 内田悠理香, 吉冨愛子, 丸山貴之, 江國大輔, 森田学

口腔衛生学会雑誌 72 ( 増刊 ) 101 - 101 2022年4月

大学病院における口腔ケア岡山大学病院頭頸部がんセンターにおける顎骨再建後のインプラントと口腔ケアの重要性

水川展吉, 武田斉子, 木股敬裕, 松本洋, 安藤瑞生, 丸山貴之, 佐々木禎子, 田中祐貴, 上田明広, 飯田征二

日本口腔ケア学会雑誌 16 ( 3 ) 83 - 83 2022年4月

家庭での毎日の受動喫煙曝露は大学生の歯周病と関係する(横断研究)

江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, 外山直樹, イスラム・モハマド・モニルル, 澤田ななみ, 中原桃子, 中島千穂, 出口純也, 福原瑶子, 森田学

口腔衛生学会雑誌 72 ( 1 ) 54 - 54 2022年1月

岡山大学新入生の口腔健康状態および主観的口腔健康評価の9年間の変化

中原桃子, 外山直樹, 江國大輔, 竹内倫子, 丸山貴之, 横井彩, 福原大樹, イスラム・モハマド・モニルル, 澤田ななみ, 中島千穂, 出口純也, 森田学

口腔衛生学会雑誌 72 ( 1 ) 54 - 54 2022年1月

Detection of Salivary miRNAs That Predict Chronic Periodontitis Progression: A Cohort Study. 査読国際誌

Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Yoshio Sugiura, Manabu Morita

International journal of environmental research and public health 18 ( 15 ) 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

The aim of this two-year cohort study was to investigate salivary microRNAs (miRNAs) that predict periodontitis progression. A total of 120 patients who underwent supportive periodontal therapy were recruited. Unstimulated whole saliva was collected at baseline. Two years later, 44 patients were followed up (median age, 67.1 years) and divided into two groups: progression group (n = 22), with one or more sites with clinical attachment level (CAL) progression (>3 mm compared with baseline) or tooth extraction due to periodontitis progression; and the control group (n = 22), which did not exhibit CAL progression. In the microarray analysis of salivary miRNAs, hsa-miR-5571-5p, hsa-miR-17-3p, hsa-let-7f-5p, hsa-miR-4724-3p, hsa-miR-99a-5p, hsa-miR-200a-3p, hsa-miR-28-5p, hsa-miR-320d, and hsa-miR-31-5p showed fold change values <0.5 or ≥2.0 in the progression group compared with the control group (p < 0.05). On receiver operating characteristic curve analysis, areas under the curves of hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were >0.7, indicating fair discrimination power. The expressions of salivary hsa-miR-5571-5p, hsa-let-7f-5p, hsa-miR-99a-5p, hsa-miR-28-5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. These salivary miRNAs may be new biomarkers for progression of periodontitis, and monitoring them may contribute to new diagnostics and precision medicine for periodontitis.

DOI： 10.3390/ijerph18158010

PubMed

researchmap

Parafunctional masseter muscle activity during waking is related to periodontitis progression: A pilot prospective cohort study. 査読国際誌

Daisuke Ekuni, Seiya Kato, Shigehisa Kawakami, Takayuki Maruyama, Kota Kataoka, Yoko Uchida-Fukuhara, Daiki Fukuhara, Naoki Toyama, Aya Yokoi, Md Monirul Islam, Subrina Binta Khair, Naoki Kodama, Manabu Morita

Journal of clinical periodontology 48 ( 6 ) 785 - 794 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

AIM: The purpose of this pilot prospective cohort study was to investigate the effects of parafunctional masseter muscle activity on periodontitis progression among patients receiving supporting periodontal therapy (SPT). MATERIALS AND METHODS: We collected data of patients treated at Okayama University Hospital from August 2014 to September 2018. The progression group was defined as patients with ≥2 teeth demonstrating a longitudinal loss of proximal attachment of ≥3 mm during the 3-year study period and/or at least one tooth extraction due to periodontitis progression. Surface electromyography of masseter muscles at baseline was continuously recorded while patients were awake and asleep. RESULTS: We analysed 48 patients (36 females) aged 66.8 ± 9.1 years (mean ± SD). The rate of parafunctional masseter muscle activity during waking hours and sleeping hours at baseline was 60.4% and 52.1%, respectively. Cox's proportional hazards regression model showed that the incidence of periodontitis progression was significantly associated with number of teeth present (p = 0.001) and parafunctional masseter muscle activity during waking hours (p = 0.041). CONCLUSION: Our results suggest that parafunctional masseter muscle activity during waking hours is a risk factor for periodontitis progression among patients receiving SPT.

DOI： 10.1111/jcpe.13432

PubMed

researchmap

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcpe.13432

噛みたばこ習慣のあるミャンマーでの口腔がん検診

水川展吉, Swe Swe Win, 加藤昌, 丸山貴之, 山近英樹, 木股敬裕, 飯田征二

頭頸部癌 47 ( 2 ) 244 - 244 2021年5月

「口臭による日常生活への支障」に関連する要因

佐保輝, 横井彩, 丸山貴之, 竹内倫子, 江國大輔, 森田学

日本口臭学会会誌 12 ( 1 ) 11 - 17 2021年5月

「口臭による日常生活への支障」に関連する要因

佐保輝, 横井彩, 丸山貴之, 竹内倫子, 江國大輔, 森田学

日本口臭学会会誌 12 ( 1 ) 49 - 50 2021年5月

岡山大学病院頭頸部がんセンターにおける頭頸部がん支持療法に関する臨床実習教育の取り組みについて

丸山貴之, 横井彩, 中原桃子, 佐々木禎子, 梶谷明子, 藤代万由, 中本美保, 吉田陽子, 森田学, 三浦留美, 山中玲子, 水川展吉, 浅海淳一, 安藤瑞生, 木股敬裕

日本口腔ケア学会雑誌 15 ( 3 ) 186 - 186 2021年4月

ヘルスリテラシーとリスク選好が定期的な歯科健診への受診意志に与える影響

角田伊知郎, 森田学, 江國大輔, 丸山貴之, 片岡広太, 横井彩, 福原大樹, 福原瑶子, 外山直樹, 中原桃子

口腔衛生学会雑誌 71 ( 増刊 ) 88 - 88 2021年4月

頭頸部がん治療による口腔機能・QOLへの影響縦断研究

横井彩, 丸山貴之, 中原桃子, 山中玲子, 江國大輔, 森田学

口腔衛生学会雑誌 71 ( 増刊 ) 116 - 116 2021年4月

岡山大学病院頭頸部がんセンターにおけるエピシル使用経験について

武田斉子, 水川展吉, 田村庄平, 岡田亜由美, 中田靖章, 横井彩, 丸山貴之, 松崎秀信, 松崎久美子, 藤代万由, 佐々木禎子, 山中玲子, 安藤瑞生, 木股敬裕, 浅海淳一, 飯田征二

日本口腔ケア学会雑誌 15 ( 3 ) 172 - 172 2021年4月

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue 査読

TERUMASA KOBAYASHI, TAKAYUKI MARUYAMA, TOSHIKI YONEDA, HISATAKA MIYAI, TETSUJI AZUMA, TAKAAKI TOMOFUJI, DAISUKE EKUNI, MANABU MORITA

In Vivo 34 ( 2 ) 615 - 622 2020年3月

慢性歯周炎患者の歯周状態の悪化に関連する唾液中miRNAの探索コホート研究

藤森浩平, 米田俊樹, 杉浦嘉雄, 丸山貴之, 江國大輔, 東哲司, 友藤孝明, 森田学

口腔衛生学会雑誌 70 ( 増刊 ) 158 - 158 2020年3月

Detection of Serum miRNAs Affecting Liver Apoptosis in a Periodontitis Rat Model 査読

YOSHIO SUGIURA, TOSHIKI YONEDA, KOHEI FUJIMORI, TAKAYUKI MARUYAMA, HISATAKA MIYAI, TERUMASA KOBAYASHI, DAISUKE EKUNI, TAKAAKI TOMOFUJI, MANABU MORITA

In Vivo 34 ( 1 ) 117 - 123 2020年1月

Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study. 査読国際誌

Aya Yokoi, Daisuke Ekuni, Hironobu Hata, Mayu Yamane-Takeuchi, Takayuki Maruyama, Reiko Yamanaka, Manabu Morita

Journal of applied oral science : revista FOB 27 e20180635 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. METHODOLOGY: Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). RESULTS: Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). CONCLUSION: Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.

DOI： 10.1590/1678-7757-2018-0635

PubMed

researchmap

Serum microRNAs and chronic periodontitis: A case-control study. 査読国際誌

Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Kohei Fujimori, Yoshio Sugiura, Manabu Morita

Archives of oral biology 101 57 - 63 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: An association is present between periodontitis and rates of expression of certain microRNAs (miRNAs) in periodontal tissue. However, the association between periodontitis and miRNA levels in human serum is unknown. We performed a case-control study in patients with chronic periodontitis to investigate serum miRNA levels. DESIGN: We enrolled 30 healthy patients without periodontitis and 30 patients with chronic periodontitis. Participants underwent clinical examination, case selection, and a blood draw from the antecubital vein. Serum miRNA profiles were compared in samples from participants with and without chronic periodontitis using microarray and real-time PCR. RESULTS: Microarray demonstrated seven miRNAs that were expressed <1/1.5 or >1.5 in the control group compared to the periodontitis group (p < 0.05). Real-time PCR showed that hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p were higher in the periodontitis group than the control group (p < 0.05). CONCLUSION: Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are candidate serum biomarkers for chronic periodontitis.

DOI： 10.1016/j.archoralbio.2019.03.009

PubMed

researchmap

Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. 査読国際誌

Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Hirofumi Mizuno, Yoshio Sugiura, Manabu Morita

Molecules (Basel, Switzerland) 24 ( 6 ) 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

DOI： 10.3390/molecules24061034

PubMed

researchmap

Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study. 査読

Mizuno H, Miyai H, Yokoi A, Kobayashi T, Inabu C, Maruyama T, Ekuni D, Mizukawa N, Kariya S, Nishizaki K, Kimata Y, Morita M

In vivo (Athens, Greece) 33 ( 1 ) 183 - 189 2019年1月

New oral hygiene care regimen reduces postoperative oral bacteria count and number of days with elevated fever in ICU patients with esophageal cancer. 査読

Hirofumi Mizuno, Shinsuke Mizutani, Daisuke Ekuni, Ayano Tabata-Taniguchi, Takayuki Maruyama, Aya Yokoi, Chie Omori, Kazuyoshi Shimizu, Hiroshi Morimatsu, Yasuhiro Shirakawa, Manabu Morita

Journal of oral science 60 ( 4 ) 536 - 543 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

DOI： 10.2334/josnusd.17-0381

PubMed

researchmap

The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial. 査読国際誌

Hirofumi Mizuno, Daisuke Ekuni, Takayuki Maruyama, Kota Kataoka, Toshiki Yoneda, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Jun Wada, Manabu Morita

PloS one 12 ( 11 ) e0188171 2017年11月

Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats. 査読国際誌

Hisataka Miyai, Takayuki Maruyama, Takaaki Tomofuji, Toshiki Yoneda, Tetsuji Azuma, Hirofumi Mizuno, Yoshio Sugiura, Terumasa Kobayashi, Daisuke Ekuni, Manabu Morita

Archives of oral biology 82 247 - 255 2017年10月

Expression of Salivary miR-203a-3p Was Related with Oral Health-Related Quality of Life in Healthy Volunteers. 査読国際誌

Terumasa Kobayashi, Takaaki Tomofuji, Tatsuya Machida, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Akiko Hirose, Manabu Morita

International journal of molecular sciences 18 ( 6 ) 2017年6月

Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study. 査読国際誌

Takayuki Maruyama, Takaaki Tomofuji, Tatsuya Machida, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Toshiki Yoneda, Hisataka Miyai, Hirofumi Mizuno, Daisuke Ekuni, Hiroyuki Okada, Manabu Morita

Molecular and clinical oncology 6 ( 5 ) 683 - 687 2017年5月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan-Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19-9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000-1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15-5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

DOI： 10.3892/mco.2017.1220

PubMed

researchmap

The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma. 査読

Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Takayuki Maruyama, Naofumi Tamaki, Daisuke Uchida, Hideki Onishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto, Hiroyuki Okada

Internal medicine (Tokyo, Japan) 56 ( 3 ) 243 - 251 2017年

miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. 査読国際誌

Machida T, Tomofuji T, Maruyama T, Yoneda T, Ekuni D, Azuma T, Miyai H, Mizuno H, Kato H, Tsutsumi K, Uchida D, Takaki A, Okada H, Morita M

Oncology reports 36 ( 4 ) 2375 - 81 2016年10月

Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma. 査読国際誌

Daisuke Uchida, Akinobu Takaki, Hisashi Ishikawa, Yasuko Tomono, Hironari Kato, Koichiro Tsutsumi, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Ryuichiro Tsuzaki, Tetsuya Yasunaka, Kazuko Koike, Hiroshi Matsushita, Fusao Ikeda, Yasuhiro Miyake, Hidenori Shiraha, Kazuhiro Nouso, Ryuichi Yoshida, Yuzo Umeda, Susumu Shinoura, Takahito Yagi, Toshiyoshi Fujiwara, Manabu Morita, Masaki Fukushima, Kazuhide Yamamoto, Hiroyuki Okada

Free radical research 50 ( 7 ) 732 - 43 2016年7月

MicroRNAs as serum biomarkers for periodontitis. 査読国際誌

Takaaki Tomofuji, Toshiki Yoneda, Tatsuya Machida, Daisuke Ekuni, Tetsuji Azuma, Kota Kataoka, Takayuki Maruyama, Manabu Morita

Journal of clinical periodontology 43 ( 5 ) 418 - 25 2016年5月

MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging. 査読国際誌

Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Takayuki Maruyama, Toshiki Yoneda, Yuya Kawabata, Hirofumi Mizuno, Hisataka Miyai, Muneyoshi Kunitomo, Manabu Morita

International journal of molecular sciences 16 ( 9 ) 21294 - 309 2015年9月

Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. 査読国際誌

Tetsuji Azuma, Mayu Yamane, Daisuke Ekuni, Yuya Kawabata, Kota Kataoka, Kenta Kasuyama, Takayuki Maruyama, Takaaki Tomofuji, Manabu Morita

Antioxidants (Basel, Switzerland) 4 ( 3 ) 513 - 22 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The control group (n = 6) or the HW group (n = 7). In the HW group, participants consumed HW 4-5 times/day for eight weeks. At two to four weeks, all participants received non-surgical periodontal treatment. Oral examinations were performed at baseline, two, four and eight weeks, and serum was obtained at these time points to evaluate oxidative stress. At baseline, there were no significant differences in periodontal status between the control and HW groups. The HW group showed greater improvements in probing pocket depth and clinical attachment level than the control group at two, four and eight weeks (p < 0.05). The HW group also exhibited an increased serum level of total antioxidant capacity at four weeks, compared to baseline (p < 0.05). Drinking HW enhanced the effects of non-surgical periodontal treatment, thus improving periodontitis.

DOI： 10.3390/antiox4030513

PubMed

researchmap

Relationship between acetaldehyde concentration in mouth air and tongue coating volume 査読

Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Daisuke Ekuni, Takaaki Tomofuji, Haruhiko Kashiwazaki, Yutaka Yamazaki, Manabu Morita

JOURNAL OF APPLIED ORAL SCIENCE 23 ( 1 ) 64 - 70 2015年1月

Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control Study. 査読

Masako Terao, Akinobu Takaki, Takayuki Maruyama, Hiroki Oe, Tetsuya Yasunaka, Naofumi Tamaki, Kazufumi Nakamura, Takaaki Tomofuji, Takahito Yagi, Hiroshi Sadamori, Yuzo Umeda, Susumu Shinoura, Ryuichi Yoshida, Kazuhiro Nouso, Daisuke Ekuni, Kazuko Koike, Fusao Ikeda, Hidenori Shiraha, Manabu Morita, Hiroshi Ito, Toshiyoshi Fujiwara, Kazuhide Yamamoto

Internal medicine (Tokyo, Japan) 54 ( 22 ) 2815 - 26 2015年

Severe periodontitis is inversely associated with coffee consumption in the maintenance phase of periodontal treatment. 査読国際誌

Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Noriko Takeuchi, Takayuki Maruyama, Shinsuke Mizutani, Kota Kataoka, Yuya Kawabata, Manabu Morita

Nutrients 6 ( 10 ) 4476 - 90 2014年10月

アルコール摂取後のブラッシング行動と歯周病の活動性との関連

水谷慎介, 江國大輔, 友藤孝明, 山根真由, 東哲司, 丸山貴之, 町田達哉, 米田俊樹, 片岡広太, 佐久本雅美, 川端勇也, 大森智栄, 森田学

口腔衛生学会雑誌 64 ( 2 ) 173 - 173 2014年4月

Occlusion and Weight Change in a Patient After Esophagectomy: Success Derived from Restoration of Occlusal Support 査読

Reiko Yamanaka, Yoshihiko Soga, Mami Minakuchi, Kumiko Nawachi, Takayuki Maruyama, Takuo Kuboki, Manabu Morita

INTERNATIONAL JOURNAL OF PROSTHODONTICS 26 ( 6 ) 574 - 576 2013年11月

Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma. 査読国際誌

Mamoru Nishimura, Akinobu Takaki, Naofumi Tamaki, Takayuki Maruyama, Hideki Onishi, Sayo Kobayashi, Kazuhiro Nouso, Tetsuya Yasunaka, Kazuko Koike, Hiroaki Hagihara, Kenji Kuwaki, Shinichiro Nakamura, Fusao Ikeda, Yoshiaki Iwasaki, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto

Hepatology research : the official journal of the Japan Society of Hepatology 43 ( 10 ) 1078 - 92 2013年10月

Relationship between serum albumin concentration and periodontal condition in patients with head and neck cancer. 査読国際誌

Takayuki Maruyama, Reiko Yamanaka, Aya Yokoi, Daisuke Ekuni, Takaaki Tomofuji, Nobuyoshi Mizukawa, Tomoo Onoda, Motoharu Eguchi, Manabu Morita

Journal of periodontology 83 ( 9 ) 1110 - 5 2012年9月

Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats. 査読

Takaaki Tomofuji, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, Naofumi Tamaki, Takayuki Maruyama, Tatsuo Yamamoto, Tatsuo Watanabe, Manabu Morita

Biomedical research (Tokyo, Japan) 32 ( 5 ) 343 - 9 2011年10月

Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. 査読国際誌

Takayuki Maruyama, Takaaki Tomofuji, Yasumasa Endo, Koichiro Irie, Tetsuji Azuma, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Manabu Morita

Archives of oral biology 56 ( 1 ) 48 - 53 2011年1月

Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. 査読国際誌

Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Tetsuji Azuma, Naofumi Tamaki, Koichiro Irie, Takayuki Maruyama, Tatsuo Yamamoto, Tatsuo Watanabe, Mutsumi Miyauchi, Takashi Takata

Acta odontologica Scandinavica 67 ( 4 ) 200 - 5 2009年7月

Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress. 査読国際誌

Daisuke Ekuni, Takaaki Tomofuji, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

Archives of oral biology 54 ( 5 ) 495 - 502 2009年5月

Validity of a questionnaire for periodontitis screening of Japanese employees. 査読国際誌

Tatsuo Yamamoto, Reiko Koyama, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Daisuke Ekuni, Reiko Yamanaka, Tetsuji Azuma, Manabu Morita

Journal of occupational health 51 ( 2 ) 137 - 43 2009年3月

Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. 査読国際誌

Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

Free radical biology & medicine 46 ( 2 ) 163 - 8 2009年1月

Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. 査読国際誌

Takaaki Tomofuji, Toshihiro Sanbe, Daisuke Ekuni, Tetsuji Azuma, Koichiro Irie, Takayuki Maruyama, Naofumi Tamaki, Tatsuo Yamamoto

Archives of oral biology 53 ( 12 ) 1113 - 8 2008年12月

Relationship between periodontal condition and plasma reactive oxygen metabolites in patients in the maintenance phase of periodontal treatment. 査読国際誌

Naofumi Tamaki, Takaaki Tomofuji, Takayuki Maruyama, Daisuke Ekuni, Reiko Yamanaka, Noriko Takeuchi, Tatsuo Yamamoto

Journal of periodontology 79 ( 11 ) 2136 - 42 2008年11月

Effects of Ethanol Consumption on Periodontal Inflammation in Rats 査読

K. Irie, T. Tomofuji, N. Tamaki, T. Sanbe, D. Ekuni, T. Azuma, T. Maruyama, T. Yamamoto

Journal of Dental Research 87 ( 5 ) 456 - 460 2008年5月

歯周組織の状態と血漿の酸化ストレス度・抗酸化力との関係

丸山貴之, 玉木直文, 友藤孝明, 江國大輔, 山中玲子, 竹内倫子, 山本龍生

特定非営利活動法人日本歯周病学会学術大会プログラムおよび講演抄録集 2008 52 - 52 2008年

　前のページ - 次のページ　

<丸山 貴之>

論文 - 丸山 貴之

<丸山　貴之>

論文 - 丸山　貴之