研究者詳細 - 井澤　俊

論文 - 井澤　俊

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Comprehensive clinical evaluation of indirect and direct bonding techniques in orthodontic treatment: a single-centre, open-label, quasi-randomized controlled clinical trial 査読

Kana Kono, Takashi Murakami, Saori Tanizaki, Noriaki Kawanabe, Atsuro Fujisawa, Masahiro Nakamura, Mitsuhiro Hoshijima, Takashi Izawa, Hiroshi Kamioka

European Journal of Orthodontics 46 ( 6 ) cjae036 2024年12月

Clinical Prediction Models for Upper Airway Volume Based on Soft Palate and Airway Lumen Dimensions in Adults With Varying Vertical Skeletal Patterns

Janvier Habumugisha, Sumire Ida, Masahiro Nakamura, Kana Kono, Kenta Uchida, Takumi Moriya, Megumi Konko, Satoru Hayano, Takashi Izawa, Hiroshi Kamioka

International Dental Journal 2024年10月

Novel prediction models for pharyngeal-airway volume based on the cranial-base and midsagittal cross-sectional area of the airway in the pharyngeal region: a cephalometric and magnetic resonance imaging study. 査読

Habumugisha J, Nakamura M, Kono K, Uchida K, Konko M, Izawa T, Kamioka H

Orthodontics and Craniofacial Research 27 ( 3 ) 394 - 402 2024年6月

NSAIDs系鎮痛薬の常用による歯の移動の遅延を認めた上下顎前突症例の一治験例

中西泰之, 植田紘貴, 星島光博, 井澤俊, 上岡寛

日本矯正歯科学会大会プログラム・抄録集 81回 229 - 229 2022年10月

HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P ₁ signaling axis 査読

Islamy Rahma Hutami, Takashi Izawa, Tsendsuren Khurel‐Ochir, Takuma Sakamaki, Akihiko Iwasa, Shuhei Tomita, Eiji Tanaka

Oral Diseases 28 ( 4 ) 1157 - 1169 2022年5月

ThPOK inhibits osteoclast formation via NFATc1 transcription and function 査読国際共著国際誌

Wei Zou, Takashi Izawa, Nidhi Rohatgi, Steven Y Zou, Yongjia Li, Steven L Teitelbaum

JBMR Plus 6 ( 4 ) e10613 2022年3月

低出力超音波パルス照射は機械的負荷に起因して生じた下顎頭軟骨変性を修復する

坂巻拓馬, 岩浅亮彦, Xia Linze, 井澤俊, 加納史也, 山本朗仁, 田中栄二

日本顎関節学会雑誌 33 ( Suppl. ) 80 - 80 2021年10月

O‐GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics‐oriented study 査読国際誌

Yao Weng, Ziyi Wang, Yoko Fukuhara, Airi Tanai, Mika Ikegame, Daisuke Yamada, Takeshi Takarada, Takashi Izawa, Satoru Hayano, Kaya Yoshida, Hiroshi Kamioka, Hirohiko Okamura

BioFactors 47 ( 6 ) 992 - 1015 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

This study aimed to reveal the possible mechanisms by which O-linked-N-acetylglucosaminylation (O-GlcNAcylation) regulates osteoblast differentiation using a series of bioinformatics-oriented experiments. To examine the influence of O-GlcNAcylation levels on osteoblast differentiation, osteoblastic MC3T3-E1 cells were treated with O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) inhibitors. Correlations between the levels of O-GlcNAcylation and the expression of osteogenic markers as well as OGT were evaluated by qPCR and western blotting. The O-GlcNAcylated proteins assumed to correlate with Runx2 expression were retrieved from several public databases and used for further bioinformatics analysis. Following the findings of the bioinformatics analysis, intracellular calcium ([Ca2+ ]i ) was monitored in the cells treated with OGT and OGA inhibitors using a confocal laser-scanning microscope (CLS). The interaction effect between O-GlcNAcylation and [Ca2+ ]i on osteogenic marker expression was determined using stable OGT knockdown MC3T3-E1 cells. O-GlcNAcylation was positively associated with osteoblast differentiation. The time-course profile of global O-GlcNAcylated proteins showed a distinctive pattern with different molecular weights during osteoblast differentiation. The expression pattern of several O-GlcNAcylated proteins was significantly similar to that of Runx2 expression. Bioinformatic analysis of the retrieved Runx2-related-O-GlcNAcylated-proteins revealed the importance of [Ca2+ ]i . CLS showed that alteration of O-GlcNAcylation rapidly changed [Ca2+ ]i in MC3T3-E1 cells. O-GlcNAcylation and [Ca2+ ]i showed an interaction effect on the expression of osteogenic markers. OGT knockdown disrupted the [Ca2+ ]i -induced expression changes of osteogenic markers. O-GlcNAcylation interacts with [Ca2+ ]i and elicits osteoblast differentiation by regulating the expression of osteogenic markers.

DOI： 10.1002/biof.1774

PubMed

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/biof.1774

Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling 査読

Islamy Hutami, Takashi Izawa, Tsendsuren Khurel-Ochir, Takuma Sakamaki, Akihiko Iwasa, Eiji Tanaka

International Journal of Molecular Sciences 22 ( 16 ) 8992 - 8992 2021年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Accumulating evidence indicates that the molecular pathways mediating wound healing induce cell migration and localization of cytokines to sites of injury. Macrophages are immune cells that sense and actively respond to disturbances in tissue homeostasis by initiating, and subsequently resolving, inflammation. Hypoxic conditions generated at a wound site also strongly recruit macrophages and affect their function. Hypoxia inducible factor (HIF)-1α is a transcription factor that contributes to both glycolysis and the induction of inflammatory genes, while also being critical for macrophage activation. For the latter, HIF-1a regulates sphingosine 1-phosphate (S1P) to affect the migration, activation, differentiation, and polarization of macrophages. Recently, S1P and HIF-1α have received much attention, and various studies have been performed to investigate their roles in initiating and resolving inflammation via macrophages. It is hypothesized that the HIF-1α/S1P/S1P receptor axis is an important determinant of macrophage function under inflammatory conditions and during disease pathogenesis. Therefore, in this review, biological regulation of monocytes/macrophages in response to circulating HIF-1α is summarized, including signaling by S1P/S1P receptors, which have essential roles in wound healing.

DOI： 10.3390/ijms22168992

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Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis 査読

Yuri Yoshikawa, Takashi Izawa, Yusaku Hamada, Hiroko Takenaga, Ziyi Wang, Naozumi Ishimaru, Hiroshi Kamioka

Scientific Reports 11 ( 1 ) 14927 2021年7月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

<title>Abstract</title>Bone loss due to smoking represents a major risk factor for fractures and bone osteoporosis. Signaling through the aryl hydrocarbon receptor (AhR) and its ligands contributes to both bone homeostasis and inflammatory diseases. It remains unclear whether the same AhR signaling axis affects the temporomandibular joint (TMJ). The aim of this study was to investigate possible mechanisms which mediate bone loss in the TMJ due to smoking. In particular, whether benzo[<italic>a</italic>]pyrene (B[<italic>a</italic>]P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles. Possible functions of an endogenous ligand of FICZ, were also investigated in a TMJ-osteoarthritis (OA) mouse model. B[<italic>a</italic>]P was administered orally to wild-type and <italic>AhR</italic>^−/− mice and bone metabolism was subsequently examined. TMJ-OA was induced in wild-type mice with forceful opening of the mouth. Therapeutic functions of FICZ were detected with μCT and histology. Exposure to B[<italic>a</italic>]P accelerated bone loss in the mandibular subchondral bone. This bone loss manifested with osteoclastic bone resorption and upregulated expression of Cyp1a1 in an <italic>AhR</italic>-dependent manner. In a mouse model of TMJ-OA, FICZ exhibited a dose-dependent rescue of mandibular subchondral bone loss by repressing osteoclast activity. Meanwhile, in vitro, pre-treatment with FICZ reduced RANKL-mediated osteoclastogenesis. B[<italic>a</italic>]P regulates mandibular subchondral bone metabolism via the Cyp1a1. The AhR ligand, FICZ, can prevent TMJ-OA by regulating osteoclast differentiation.

DOI： 10.1038/s41598-021-94470-4

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その他リンク： http://www.nature.com/articles/s41598-021-94470-4

The immunoregulatory role of p21 in the development of the temporomandibular joint‐osteoarthritis 査読

Tsendsuren Khurel‐Ochir, Takashi Izawa, Akihiko Iwasa, Fumiya Kano, Akihito Yamamoto, Eiji Tanaka

Clinical and Experimental Dental Research 7 ( 3 ) 313 - 322 2021年6月

下垂体機能低下を伴う中隔視神経異形成症患者の矯正歯科治療症例査読

河野加奈, 柳田剛志, 井澤俊, 上岡寛

岡山歯学会雑誌 40 ( 1 ) 1 - 10 2021年6月

Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes 査読国際誌

Ziyi Wang, Yao Weng, Yoshihito Ishihara, Naoya Odagaki, Ei Ei Hsu Hlaing, Takashi Izawa, Hirohiko Okamura, Hiroshi Kamioka

PeerJ 8 e10244 - e10244 2020年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PeerJ

<sec>
<title>Background</title>
In this study, we investigated the effect of the mechanical loading history on the expression of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in MLO-Y4 osteocyte-like cells.

</sec>
<sec>
<title>Methods</title>
Three hours after MLO-Y4 osteocytes were seeded, a continuous compressive force (CCF) of 31 dynes/cm² with or without additional CCF (32 dynes/cm²) was loaded onto the osteocytes. After 36 h, the additional CCF (loading history) was removed for a recovery period of 10 h. The expression of RANKL, OPG, RANKL/OPG ratio, cell numbers, viability and morphology were time-dependently examined at 0, 3, 6 and 10 h. Then, the same additional CCF was applied again for 1 h to all osteocytes with or without the gap junction inhibitor to examine the expression of RANKL, OPG, the RANKL/OPG ratio and other genes that essential to characterize the phenotype of MLO-Y4 cells. Fluorescence recovery after photobleaching technique was also applied to test the differences of gap-junctional intercellular communications (GJIC) among MLO-Y4 cells.

</sec>
<sec>
<title>Results</title>
The expression of RANKL and OPG by MLO-Y4 osteocytes without a loading history was dramatically decreased and increased, respectively, in response to the 1-h loading of additional weight. However, the expression of RANKL, OPG and the RANKL/OPG ratio were maintained at the same level as in the control group in the MLO-Y4 osteocytes with a loading history but without gap junction inhibitor treatment. Treatment of loading history significantly changed the capacity of GJIC and protein expression of connexin 43 (Cx43) but not the mRNA expression of Cx43. No significant difference was observed in the cell number or viability between the MLO-Y4 osteocyte-like cells with and without a loading history or among different time checkpoints during the recovery period. The cell morphology showed significant changes and was correlated with the expression of OPG, Gja1 and Dmp1 during the recovery period.

</sec>
<sec>
<title>Conclusion</title>
Our findings indicated that the compressive force-induced changes in the RANKL/OPG expression could be habituated within at least 11 h by 36-h CCF exposure. GJIC and cell morphology may play roles in response to loading history in MLO-Y4 osteocyte-like cells.

</sec>

DOI： 10.7717/peerj.10244

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その他リンク： https://peerj.com/articles/10244.xml

核内受容体AhRはRANK/c-Fosシグナル伝達経路を介して破骨細胞の分化を制御する

井澤俊, 吉川友理, 石丸直澄, 上岡寛

日本骨形態計測学会雑誌 30 ( 1 ) S97 - S97 2020年5月

Skeletal open bite with amelogenesis imperfecta treated with compression osteogenesis: a case report. 査読

Mori H, Izawa T, Mori H, Watanabe K, Kanno T, Tanaka E

Head Face Med 15 ( 1 ) 3 2019年1月

Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis 査読

Hutami IR, Tanaka E, Izawa T

Japanese Dental Science Review 55 ( 1 ) 12 - 19 2019年1月

矯正患者における永久歯の先天欠如に関する臨床統計調査査読

小笠原直子, 岩浅亮彦, 堀内信也, 井澤俊, 田中栄二

中・四国矯正歯科学会雑誌 30 ( 1 ) 59 - 64 2018年8月

Effectiveness of presurgical nasoalveolar molding therapy on unilateral cleft lip nasal deformity 査読

Nao Kinouchi, Shinya Horiuchi, Akihiro Yasue, Yuko Kuroda, Nobuhiko Kawai, Keiichiro Watanabe, Takashi Izawa, Ichiro Hashimoto, Ali H. Hassan, Eiji Tanaka

Saudi Medical Journal 39 ( 2 ) 169 - 178 2018年2月

Potential role of rebamipide in osteoclast differentiation and mandibular condylar cartilage homeostasis 査読

Takashi Izawa, Islamy Rahma Hutami, Eiji Tanaka

Current Rheumatology Reviews 14 ( 1 ) 62 - 69 2018年

Skeletal anchorage for intrusion of bimaxillary molars in a patient with skeletal open bite and temporomandibular disoeders. 査読

Iwasa A, Horiuchi S, Kinouchi N, Izawa T, Hiasa M, Kawai N, Yasue A, Hassan AH, Tanaka E

Journal of Orthodontic Science 6 ( 4 ) 152 - 158 2017年10月

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