研究者詳細 - 前田　恵

論文 - 前田　恵

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Asbestos induces reduction of tumor immunity. 査読国際誌

Kumagai-Takei N, Maeda M, Chen Y, Matsuzaki H, Lee S, Nishimura Y, Hiratsuka J, Otsuki T

Clinical & developmental immunology 2011 481439 - 481439 2011年

Structural features and Immunological activity of N-glycans of seaweed glyco- proteins. 査読

Yoshiie T, Maeda M, Kimura M, Kimura Y

Glycoconjugate Journal 28 ( 5 ) 2011年

Establishment of negatively-charged indoor air conditions and their biological effects

Takemi Otsuki, Kazuaki Takahashi, Akinori Mase, Takashi Kawado, Muneo Kotani, Yasumitsu Nishimura, Megumi Maeda, Shuko Murakami, Naoko Kumagai, Hiroaki Hayashi, Ying Chen, Yoshie Miura, Takashi Shirahama, Michiharu Yoshimatsu, Kanehisa Morimoto

Buildings and the Environment 201 - 214 2010年12月

Indoor air condition may be involved to the health status. Among various factors inindoor air conditions, few reports were published concerning negatively chargedparticles.In this review, we detaile the biological effects of negatively-charged indoorair conditions, particularly on the psycho-neuro-endocrino-immune network. The short-term (2.5 hours) and mmedium-term (2 weeks) abidance of negatively-charged airparticle dominant room resulted activation of natural killer cell activity induced byrecurrent transient activation of interleukin 2. These results indicate that negativelychargedindoor air condition is better for immune status and may improve daily lives. © 2009 Nova Science Publishers, Inc. All rights reserved.

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Dysregulation of the immune system caused by silica and asbestos. 査読

Maeda M, Nishimura Y, Kumagai N, Hayashi H, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Hirastuka J, Otsuki T

Journal of immunotoxicology 7 ( 4 ) 268 - 278 2010年10月

珪酸・アスベストの免疫影響（ミニ特集：繊維･粒子状物質研究会（仙台））査読

熊谷直子, 西村泰光, 前田恵, 林宏明, 大槻剛巳

日本衛生学雑誌 64 ( 4 ) 493 - 499 2010年10月

[Immunological effects of silica/asbestos]. 査読

Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T

Nihon eiseigaku zasshi. Japanese journal of hygiene 65 ( 4 ) 493 - 9 2010年9月

Intracellular and extracellular free N-glycans produced by plant cells: Occurrence of unusual plant complex-type free N-glycans in extracellular speces. 査読国際誌

Maeda M, Kimura M, Kimura Y

J. Biocem. 148 ( 6 ) 681 - 692 2010年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

植物細胞の新生たんぱく質の品質管理系における脱グリコシル化機構を明らかにする目的で、イネ培養細胞が産生する遊離型Ｎ－グリカンの構造特性解析を行った。得られた結果は、これまでに知られていない新たな糖鎖遊離機構が存在することを示唆するものであった。

DOI： 10.1093/jb/mvq102

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珪肺症例における自己免疫異常の検出血清可溶性インターロイキン2受容体と可溶性CD40リガンドの濃度の意義

林宏明, 西村泰光, 前田恵, 熊谷直子, 村上周子, 三浦由恵, 草加勝康, 浦上更三, 大槻剛巳

日本職業・災害医学会会誌 58 ( 2 ) 45 - 51 2010年3月

記述言語：日本語出版者・発行元：(一社)日本職業・災害医学会

珪肺症例では肺病変のみならず自己寛容の破綻が生じ、慢性関節リウマチや強皮症の合併が知られている。これらの自己免疫異常の血清学的な指標として可溶性インターロイキン2受容体(sIL-2R)や可溶性CD40リガンド(sCD40L)が有用かどうかを健常人、珪肺症例、強皮症症例で検討した結果を総括して、珪酸の制御性T細胞や活性化T細胞など、自己寛容の破綻に関連する細胞群への影響について概説する。(著者抄録)

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その他リンク： http://search.jamas.or.jp/link/ui/2010218223

Reductive alteration of the regulatory function of the CD4(+)CD25(+) T cell fraction in silicosis patients. 査読

H. Hayashi, Y. Miura, M. Maeda, S. Murakami, N. Kumagai, Y. Nishimura, M. Kusaka, K. Urakami, W. Fujimoto, T. Otsuki

International journal of immunopathology and pharmacology 23 1099 - 1109 2010年1月

Causal links have been documented between silica and rheumatoid arthritis, lupus erythematosus, systemic sclerosis and glomerulonephritis. Two different effects of silica have been suggested, an enhanced inflammatory response in the pulmonary region (e.g. activation of alveolar macrophages) and dysregulation of autoimmunity. Based on our previous reports showing in vitro activation of peripheral T cells by silica and reduced regulatory function of the peripheral CD4(+)CD25(+) fraction in which FoxP(3)+ regulatory T cells (Treg) are located, reconstitution of the CD4(+)CD25(+) fraction in silicosis patients (SILs) was investigated. Since T cells in peripheral CD4(+)CD25(+) and CD4(+)CD25(-) (effector T cells; Teff) fractions from SILs showed higher expression of pd-1 (a marker gene for T cell activation) in comparison to that of healthy donors (HDs), chronic T cell activation was considered to have occurred in SILs. In this study, a higher expression of the CD95/Fas molecule in Treg was recorded from silicosis patients (SILs) compared to healthy donors (HDs), and excess loss of FoxP3(+) Treg in freshly isolated peripheral blood mononuclear cells (PBMCs) from SILs relative to HDs was demonstrated when these cells were cultured with silica ex vivo, whereas CD25(+) cells were not reduced due to contamination of activated Teff in the CD4(+)CD25(+) fraction. The activation of both Teff and Treg results in reconstitution of the peripheral CD4(+)CD25(+) fraction, loss of Treg and contamination of activated Teff, resulting in reduction of the number and function of Treg. These results contribute to our understanding of the development of autoimmune diseases found in SILs.

DOI： 10.1177/039463201002300414

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Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients? 査読

HAYASHI Hiroaki, NISHIMURA Yasumitsu, MAEDA Megumi, MURAKAMI Shuko, KUMAGAI Naoko, CHEN Ying, KUSAKA Masayasu, URAKAMI Kozo, FUJIMOTO Wataru, OTSUKI Takemi

川崎医学会誌 35 ( 2 ) 129 - 138 2009年12月

The biological effects of negatively-charged indoor air conditions 査読

OTSUKI Takemi, TAKAHASHI Kazuaki, MASE Akinori, KAWADO Takashi, KOTANI Muneo, MAEDA Megumi, MURAKAMI Shuko, KUMAGAI Naoko, HAYASHI Hiroaki, CHEN Ying, NISHIMURA Yasumitsu, MIURA Yoshie, SHIRAHAMA Takashi, YOSHIMATSU Michiharu, MORIMOTO Kanehisa

川崎医学会誌 35 ( 3 ) 205 - 214 2009年10月

Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. 査読国際誌

Shuko Murakami, Yasumitsu Nishimura, Megumi Maeda, Naoko Kumagai, Hiroaki Hayashi, Ying Chen, Masayasu Kusaka, Takumi Kishimoto, Takemi Otsuki

Environmental health and preventive medicine 14 ( 4 ) 216 - 22 2009年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

This review is partly composed of the presentation "Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases" delivered during the symposium "Biological effects of fibrous and particulate substances and related areas" organized by the Study Group of Fibrous and Particulate Studies of the Japanese Society of Hygiene and held at the 78th Annual Meeting in Kumamoto, Japan. In this review, we briefly introduce the results of recent immunological analysis using the plasma of silica and asbestos-exposed patients diagnosed with silicosis, pleural plaque, or malignant mesothelioma. Thereafter, experimental background and speculation concerning the immunological pathophysiology of silica and asbestos-exposed patients are discussed.

DOI： 10.1007/s12199-008-0063-8

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マイナス荷電粒子優位な室内空気環境の生体影響の観察精神・神経・内分泌・免疫ネットワークへの影響について

西村泰光, 高橋一聡, 間瀬昭則, 河戸隆, 小谷宗男, 阿見和久, 松島弘樹, 白濱毅, 吉松道晴, 前田恵, 村上周子, 林宏明, 熊谷直子, 陳瑩, 三浦由恵, 森本謙曩, 大槻剛巳

日本職業・環境アレルギー学会雑誌 16 ( 2 ) 15 - 24 2009年5月

記述言語：日本語出版者・発行元：日本職業・環境アレルギー学会

室内環境によって相互に関連する精神、神経、内分泌ならびに免疫の相互作用(PNEI(psycho-neuro-endocrino-immune)-ネットワーク)に影響するシックハウス症候群や化学物質過敏症が知られているが、室内環境の改善は健康増進という観点からも重要である。マイナス荷電粒子優位な室内環境を構築し、そのPNEIネットワークに及ぼす影響を検討したところ、時間単位の短期滞在試験では血清IL-2の上昇、週単位の中期滞在試験ではNK細胞の活性化が認められた。ストレス指標などには顕著な影響は認められなかったが、悪影響もなく今後月〜年単位の長期居住の影響あるいは細胞や遺伝子レベルへの影響の検討も興味深いと考えられた。また、森林浴などの健康効果の一部にもマイナス荷電粒子の影響が及んでいることも想定された。(著者抄録)

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Two weeks of permanence in negatively-charged air conditions causes alteration of natural killer cell function 査読

K. Takahashi, Takemi Otsuki, Takemi Otsuki, A. Mase, T. Kawado, M. Kotani, Y. Nishimura, M. Maeda, S. Murakami, N. Kumagai, H. Hayashi, Y. Chen, T. Shirahama, Y. Miura, K. Morimoto

International Journal of Immunopathology and Pharmacology 22 333 - 342 2009年1月

掲載種別：研究論文（学術雑誌）

The effects of negatively-charged air conditions were analyzed as one of the approaches to improve health and quality of life. We previously reported that the use of a charcoal coating and application of an electric voltage yielded predominantly negatively-charged particles in an experimental room, and that 2.5 hours of living in these conditions caused a slight activation of the immune system (slight elevation of serum interleukin (IL)-2), regulated blood flow, and stabilized the autonomic nervous system when compared with control conditions (no dominance of negatively-charged particles). In this study, we expanded the previous study and placed 15 subjects in negatively-charged air conditions for two weeks during the night and analyzed various biological parameters. Although individual biological reactions differed from subject to subject, natural killer (NK) cell activity increased significantly following living in negatively-charged air conditions. Taken together, the results of the previous investigation and those of this study show that repeated elevation of IL-2 (although it immediately returned to the baseline level) causes chronic and recurrent stimulation to NK cells and results in the steady activation of NK cells. Negatively-charged air particles may be a good tool to improve health and quality of life. Copyright © by Biolife, s.a.s.

DOI： 10.1177/039463200902200210

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Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: the 'Power Rehabilitation' program. 査読国際誌

Shin-Ichiro Murakami, Takemi Otsuki, Megumi Maeda, Yoshie Miura, Seiko Morii, Kenji Kiyokane, Shin-Ichi Hayakawa, Atsushi Maeda, Takayo Imakawa, Shunpei Harada, Torataro Handa, Yasumitsu Nishimura, Shuko Murakami, Naoko Kumagai, Hiroaki Hayashi, Ying Chen, Shin-Ichiro Suemori, Yumiko Fukushima, Seikoh Nishida, Keisuke Fukushima

International journal of molecular medicine 23 ( 1 ) 81 - 8 2009年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.

DOI： 10.3892/ijmm_00000104

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Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos 査読

Yasumitsu Nishimura, M. Maeda, N. Kumagai, H. Hayashi, Y. Miura, T. Otsuki

International Journal of Immunopathology and Pharmacology 22 ( 4 ) 879 - 888 2009年

掲載種別：研究論文（学術雑誌）

YT-CB5, which had been continuously cultured with chrysotile B (CB) asbestos, showed impaired cytotoxicity with decreased expression of NKG2D and 2B4 NK cell-activating receptors. In the present study, the phosphorylation of extracellular signal-regulated kinase (ERK), which is known to induce degranulation downstream of many NK cell-activating receptors, was examined in YT-CB5 by flow cytometry and compared with the control line YT-Org. YT-CB5 exhibited impaired phosphorylation of ERK1/2 induced by the recognition of K562 cells, downstream of a process mediated by Src family kinase and phosphoinositide 3-kinase. YT-CBS also exhibited impaired phosphorylation of ERK1/2 following incubation with K562 cells in the presence of anti-2B4 antibodies, where co-stimulation by 2B4 augmented the phosphorylation of ERK1/2 in YT-CB5 to a similar degree as in YT-Org. The phosphorylation of ERK1/2 induced by an inhibitor against phosphatase (PP) 1 and PP2A was also lower in YT-CB5 compared with YT-Org. Moreover, bead-bound antibodies to NKG2D, which contribute to cytotoxicity against K562 cells, induced negligible phosphorylation of ERK1/2 in YT-CB5, although antibodies to 2B4. induced a comparatively greater level of phosphorylation. Additionally, peripheral blood (PB-) NK cells with low expression of NKG2D showed lower phosphorylation of ERK1/2 mediated by anti-NKG2D antibodies compared with PB-NK cells with high expression of NKG2D. These results indicate that signal transduction events leading to the phosphorylation of ERK is impaired in YT-CB5 due to decreased expression of NKG2D. Further studies are required to clarify whether this suppressive effect of asbestos exposure on NK cells might promote lung cancer and mesothelioma in people who have inhaled asbestos. Copyright © by Biolife, s.a.s.

DOI： 10.1177/039463200902200403

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珪肺症例末梢血CD4+25+分画における慢性活性化T細胞の混入とFas分子発現

林宏明, 前田恵, 村上周子, 西村泰光, 大槻剛巳, 藤本亘

山口医学 57 ( 4 ) 111 - 112 2008年8月

繊維・粒子状物質の生体影響とその周辺アスベストの免疫系への影響と腫瘍免疫減衰

大槻剛巳, 熊谷直子, 村上周子, 前田恵, 林宏明, 西村泰光

日本衛生学雑誌 63 ( 2 ) 236 - 237 2008年3月

Y2-4 アスベストの免疫影響の検討を踏まえたアスベスト曝露症例における免疫担当細胞の変化(胸膜疾患に対する診断の開発,要望演題2,第31回日本呼吸器内視鏡学会学術集会)

大槻剛巳, 前田恵, 三浦由恵, 村上周子, 林弘明, 熊谷直子, 西村泰光, 岸本卓巳, 中野孝司

気管支学 30 S114 2008年

珪肺症例におけるCD4+25+分画における慢性活性化Ｔ細胞、Fas分子発現の検討

林宏明, 前田恵, 村上周子, 西村泰光, 草加勝康, 大槻剛巳

日本臨床免疫学会総会抄録集 35 103 - 103 2007年

記述言語：日本語出版者・発行元：日本臨床免疫学会

珪肺症の合併症として自己免疫疾患の頻度が高いことは成書にも記されている。CD4+25+FoxP3+制御性Ｔ細胞（Treg）が，自己寛容維持に重要な役割を有することが知られてきた。CD4+25+ Treg の特異的発現機能遺伝子であるFoxP3 の発現が，健常人では，CD4+25+分画で高発現，CD4+25-分画で極めて低発現なのに比し，珪肺症例ではCD4+25+分画でも，CD4+25-分画と同程度に低発現なことを以前に報告した。活性化T細胞では発現しているが，CD4+25+Treg細胞では発現していないPD-1遺伝子の発現を，珪肺症例と健常人の末梢血単核球をCD4+25+分画とCD4+25-分画において検討した。結果，健常人ではどちらの分画でも非常に低発現であったが，珪肺症例では，CD4+25-分画でも健常人より高度に，CD4+25+分画では更に高度な発現が認められた。また、CD4+FoxP3+分画のFasの発現は健常人においてもCD4+FoxP3-分画に比し高発現の度合いが高かった。これらの結果より，珪肺症例のCD4+25+分画には珪酸曝露に伴う慢性活性化T細胞が侵入し，および珪肺症例の制御性T細胞では，Fas発現が高く容易にアポトーシスに至る可能性が示唆された。その結果FoxP3+ Tregを置換，CD4+25+分画の機能の減衰をもたらして自己寛容の破綻を招いている可能性が高いと考えられた。

DOI： 10.14906/jscisho.35.0.103.0

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