Updated on 2025/12/24

写真a

 
FUJITA Hirofumi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
Homepage
http://square.umin.ac.jp/oka-anat/
External link

Degree

  • 博士（医学） ( 岡山大学 )

Research Interests

  • 分化

  • がん

  • Free radical

  • Cell death

  • Cancer

  • Bone metabolism

  • Cell differentiation

  • 骨代謝

  • 活性酸素

  • 細胞死

Research Areas

  • Life Science / Anatomy

  • Life Science / Medical biochemistry

  • Life Science / Cell biology

  • Life Science / Orthopedics

Education

  • Okayama University    

    - 2005

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  • Okayama University   医学系研究科  

    - 2005

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    Country： Japan

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Research History

  • - Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2006

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  • - 岡山大学医歯薬学総合研究科 助教

    2006

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Professional Memberships

Committee Memberships

  • 日本酸化ストレス学会   評議員  

    2008   

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    Committee type：Academic society

    日本酸化ストレス学会

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Papers

  • Harderian Gland Development and Degeneration in the Fgf10-Deficient Heterozygous Mouse. International journal

    Shiori Ikeda, Keita Sato, Hirofumi Fujita, Hitomi Ono-Minagi, Satoru Miyaishi, Tsutomu Nohno, Hideyo Ohuchi

    Journal of developmental biology   12 ( 2 )   2024.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    The mouse Harderian gland (HG) is a secretory gland that covers the posterior portion of the eyeball, opening at the base of the nictitating membrane. The HG serves to protect the eye surface from infection with its secretions. Mice open their eyelids at about 2 weeks of age, and the development of the HG primordium mechanically opens the eye by pushing the eyeball from its rear. Therefore, when HG formation is disturbed, the eye exhibits enophthalmos (the slit-eye phenotype), and a line of Fgf10+/- heterozygous loss-of-function mice exhibits slit-eye due to the HG atrophy. However, it has not been clarified how and when HGs degenerate and atrophy in Fgf10+/- mice. In this study, we observed the HGs in embryonic (E13.5 to E19), postnatal (P0.5 to P18) and 74-week-old Fgf10+/- mice. We found that more than half of the Fgf10+/- mice had markedly degenerated HGs, often unilaterally. The degenerated HG tissue had a melanized appearance and was replaced by connective tissue, which was observed by P10. The development of HGs was delayed or disrupted in the similar proportion of Fgf10+/- embryos, as revealed via histology and the loss of HG-marker expression. In situ hybridization showed Fgf10 expression was observed in the Harderian mesenchyme in wild-type as well as in the HG-lacking heterozygote at E19. These results show that the Fgf10 haploinsufficiency causes delayed or defective HG development, often unilaterally from the unexpectedly early neonatal period.

    DOI： 10.3390/jdb12020016

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  • システイニルロイコトリエン受容体CysLTR1は破骨細胞分化と骨吸収に必須ではない

    藤田 洋史, 服部 高子, 久保田 聡

    日本骨代謝学会学術集会プログラム抄録集   41回   162 - 162   2023.7

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    Language：Japanese   Publisher：(一社)日本骨代謝学会  

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  • Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress–Induced Cell Death

    Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Yuki Morizane, Hideyo Ohuchi

    Investigative Opthalmology & Visual Science   63 ( 12 )   29 - 29   2022.11

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    Publishing type：Research paper (scientific journal)   Publisher：Association for Research in Vision and Ophthalmology (ARVO)  

    DOI： 10.1167/iovs.63.12.29

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  • Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption

    Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi

    PLOS ONE   17 ( 11 )   e0277307 - e0277307   2022.11

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    Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

    Cysteinyl leukotriene receptor 1 (CysLTR1) is a G protein-coupled receptor for the inflammatory lipid mediators cysteinyl leukotrienes, which are involved in smooth muscle constriction, vascular permeability, and macrophage chemokine release. The Cysltr1 gene encoding CysLTR1 is expressed in the macrophage lineage, including osteoclasts, and the CysLTR1 antagonist Montelukast has been shown to suppress the formation of osteoclasts. However, it currently remains unclear whether CysLTR1 is involved in osteoclast differentiation and bone loss. Therefore, to clarify the role of CysLTR1 in osteoclastogenesis and pathological bone loss, we herein generated CysLTR1 loss-of-function mutant mice by disrupting the cysltr1 gene using the CRISPR-Cas9 system. These mutant mice had a frameshift mutation resulting in a premature stop codon (Cysltr1 KO) or an in-frame mutation causing the deletion of the first extracellular loop (Cysltr1Δ105). Bone marrow macrophages (BMM) from these mutant mice lost the intracellular flux of calcium in response to leukotriene D4, indicating that these mutants completely lost the activity of CysLTR1 without triggering genetic compensation. However, disruption of the Cysltr1 gene did not suppress the formation of osteoclasts from BMM in vitro. We also demonstrated that the CysLTR1 antagonist Montelukast suppressed the formation of osteoclasts without functional CysLTR1. On the other hand, disruption of the Cysltr1 gene partially suppressed the formation of osteoclasts stimulated by leukotriene D4 and did not inhibit that by glutathione, functioning as a substrate in the synthesis of cysteinyl leukotrienes. Disruption of the Cysltr1 gene did not affect ovariectomy-induced osteoporosis or lipopolysaccharide-induced bone resorption. Collectively, these results suggest that the CysLT-CysLTR1 axis is dispensable for osteoclast differentiation in vitro and pathological bone loss, while the leukotriene D4-CysTR1 axis is sufficient to stimulate osteoclast formation. We concluded that the effects of glutathione and Montelukast on osteoclast formation were independent of CysLTR1.

    DOI： 10.1371/journal.pone.0277307

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  • Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice. International journal

    Ruizhi Xue, Wenfeng Lin, Hirofumi Fujita, Jingkai Sun, Rie Kinoshita, Kazuhiko Ochiai, Junichiro Futami, Masami Watanabe, Hideyo Ohuchi, Masakiyo Sakaguchi, Zhengyan Tang, Peng Huang, Yasutomo Nasu, Hiromi Kumon

    Genes   13 ( 2 )   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    The role of Dickkopf-3 (Dkk3)/REIC (The Reduced Expression in Immortalized Cells), a Wnt-signaling inhibitor, in male reproductive physiology remains unknown thus far. To explore the functional details of Dkk3/REIC in the male reproductive process, we studied the Dkk3/REIC knock-out (KO) mouse model. By examining testicular sections and investigating the sperm characteristics (count, vitality and motility) and ultrastructure, we compared the reproductive features between Dkk3/REIC-KO and wild-type (WT) male mice. To further explore the underlying molecular mechanism, we performed RNA sequencing (RNA-seq) analysis of testicular tissues. Our results showed that spermiation failure existed in seminiferous tubules of Dkk3/REIC-KO mice, and sperm from Dkk3/REIC-KO mice exhibited inferior motility (44.09 ± 8.12% vs. 23.26 ± 10.02%, p < 0.01). The Ultrastructure examination revealed defects in the sperm fibrous sheath of KO mice. Although the average count of Dkk3/REIC-KO epididymal sperm was less than that of the wild-types (9.30 ± 0.69 vs. 8.27 ± 0.87, ×106), neither the gap (p > 0.05) nor the difference in the sperm vitality rate (72.83 ± 1.55% vs. 72.50 ± 0.71%, p > 0.05) were statistically significant. The RNA-seq and GO (Gene Oncology) enrichment results indicated that the differential genes were significantly enriched in the GO terms of cytoskeleton function, cAMP signaling and calcium ion binding. Collectively, our research demonstrates that Dkk3/REIC is involved in the process of spermiation, fibrous sheath integrity maintenance and sperm motility of mice.

    DOI： 10.3390/genes13020285

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  • UCP1 expression in the mouse adrenal gland is not upregulated by thermogenic conditions. International journal

    Hirofumi Fujita, Munenori Habuta, Takako Hattori, Satoshi Kubota, Hiromi Kumon, Hideyo Ohuchi

    Biochemical and biophysical research communications   566   184 - 189   2021.8

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    The uncoupling protein 1 (UCP1) gene is known to be highly expressed in brown adipose tissue (BAT) that functions in thermogenesis. It has been shown that UCP1 mRNA is localized to the mouse adrenal gland, but its significance remains elusive. To explore how UCP1 expression in the adrenal gland is regulated, we generated a reporter knock-in mouse in which the GFP gene was inserted into the UCP1 locus using CRISPR-Cas9 system. Firstly, we confirmed by Western blot analysis UCP1-driven GFP protein expression in interscapular BAT of the knock-in mice kept at 4 °C. Immunohistochemistry showed that GFP protein was detected in the adrenal gland of the knock-in mice. More intense GFP expression was observed in the adrenal medulla than in the cortex of the reporter mice irrespectively of cold exposure. Immunohistochemistry using anti-UCP1 antibody, as well as Western blot analysis verified UCP1 protein expression in the wild-type adrenal medulla. These results suggest that the mouse adrenal gland is a novel organ expressing UCP1 protein and its expression is not upregulated by cold exposure.

    DOI： 10.1016/j.bbrc.2021.06.013

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  • 副腎髄質におけるUCP1タンパク質発現のUCP1レポーターマウスを用いた検証(UCP1-reporter mice reveal UCP1 protein expression in the adrenal medulla)

    Fujita Hirofumi, Habuta Munenori, Hattori Takako, Kubota Satoshi, Kumon Hiromi, Ohuchi Hideyo

    The Journal of Physiological Sciences   71 ( Suppl.1 )   105 - 105   2021.8

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  • Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

    Munenori Habuta, Akihiro Yasue, Ken-ichi T. Suzuki, Hirofumi Fujita, Keita Sato, Hitomi Kono, Ayuko Takayama, Tetsuya Bando, Satoru Miyaishi, Seiichi Oyadomari, Eiji Tanaka, Hideyo Ohuchi

    PLOS ONE   15 ( 10 )   e0240333 - e0240333   2020.10

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    DOI： 10.1371/journal.pone.0240333

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  • Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.

    Hirofumi Fujita, Tetsuya Bando, Seiichi Oyadomari, Kazuhiko Ochiai, Masami Watanabe, Hiromi Kumon, Hideyo Ohuchi

    Acta medica Okayama   74 ( 3 )   199 - 208   2020.6

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    Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland.

    DOI： 10.18926/AMO/59950

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  • KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells. International journal

    Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Fumio Shiraga, Yuki Morizane, Hideyo Ohuchi

    Investigative ophthalmology & visual science   61 ( 5 )   38 - 38   2020.5

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    Purpose: The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. Methods: The two guide RNAs specific to the target sites in the KCNJ13 gene were designed and KCNJ13 knock-out (KO) human-induced pluripotent stem cells (hiPSCs) were generated using the CRISPR/Cas9 system. The KCNJ13-KO hiPSCs were differentiated into retinal pigment epithelial cells (hiPSC-RPEs). The KCNJ13-KO in hiPSC-RPEs was confirmed by immunostaining. Phagocytic activity of hiPSC-RPEs was assessed using the uptake of fluorescently labeled porcine photoreceptor outer segments (POSs). Phagocytosis-related genes in RPE cells were assessed by quantitative polymerase chain reaction. Results: Most of the translated region of the KCNJ13 gene was deleted in the KCNJ13-KO hiPSCs by the CRISPR/Cas9 system, and this confirmed that the Kir7.1 protein was not present in RPE cells induced from the hiPSCs. Expression of RPE marker genes such as BEST1 and CRALBP was retained in the wild-type (WT) and in the KCNJ13-KO hiPSC-RPE cells. However, phagocytic activity and expression of phagocytosis-related genes in the KCNJ13-null hiPSC-RPE cells were significantly reduced compared to those of WT. Conclusions: We succeeded in generating an RPE model of LCA16 using hiPSCs. We suggest that Kir7.1 is required for phagocytosis of POSs by RPE cells and that impaired phagocytosis in the absence of Kir7.1 would be involved in the retinal degeneration found in LCA16.

    DOI： 10.1167/iovs.61.5.38

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  • Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla. Reviewed

    Habuta M, Fujita H, Sato K, Bando T, Inoue J, Kondo Y, Miyaishi S, Kumon H, Ohuchi H

    Cell and tissue research   379 ( 1 )   157 - 167   2019.10

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    DOI： 10.1007/s00441-019-03113-8

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  • Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye. Reviewed

    Kato M, Sato K, Habuta M, Fujita H, Bando T, Morizane Y, Shiraga F, Miyaishi S, Ohuchi H

    Biochemistry and biophysics reports   19   100665   2019.9

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    DOI： 10.1016/j.bbrep.2019.100665

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  • Glutathione accelerates osteoclast differentiation and inflammatory bone destruction. Reviewed International journal

    Fujita H, Ochi M, Ono M, Aoyama E, Ogino T, Kondo Y, Ohuchi H

    Free radical research   53 ( 2 )   1 - 11   2019.3

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    Chronic inflammation associated with bone tissues often destructs bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It is believed that reactive oxygen species (ROS) are involved in receptor activator of NF-κB (RANK) ligand (RANKL)-induced osteoclast differentiation, and, therefore, glutathione (GSH), the most abundant endogenous antioxidant, suppresses osteoclast differentiation and bone resorption by RANKL. Interestingly, GSH also contributes to inflammatory responses, and the effects of GSH on osteoclast differentiation and bone destruction under inflammatory conditions have not yet been determined. Here, we investigated how GSH affects inflammatory cytokine-stimulated osteoclast differentiation in vitro and in a mouse model of inflammatory bone destruction. We found that GSH significantly promoted TNFα-stimulated osteoclast formation, while an inhibitor of GSH synthesis, buthionine sulfoximine, suppressed it. GSH facilitated the nuclear localisation of the nuclear factor of activated T cells c1 (NFATc1) protein, a master regulator of osteoclastogenesis, as well as the expression of osteoclast marker genes in a dose-dependent manner. N-acetylcysteine, a substrate of GSH synthesis, also stimulated osteoclast formation and NFATc1 nuclear localisation. GSH did not suppress cell death after osteoclast differentiation. In mouse calvaria injected with lipopolysaccharide, GSH treatment resulted in a fivefold increase in the osteolytic lesion area. These results indicate that GSH accelerates osteoclast differentiation and inflammatory bone destruction, suggesting GSH appears to be an important molecule in the mechanisms responsible for inflammatory bone destruction by osteoclasts.

    DOI： 10.1080/10715762.2018.1563782

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  • Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy. Reviewed

    Oka T, Mizuno H, Sakata M, Fujita H, Yoshino T, Yamano Y, Utsumi K, Masujima T, Utsunomiya A

    Scientific reports   8 ( 1 )   14979   2018.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41598-018-33175-7

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    Other Link： http://www.nature.com/articles/s41598-018-33175-7

  • Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse

    Junji Inoue, Hirofumi Fujita, Tetsuya Bando, Yoichi Kondo, Hiromi Kumon, Hideyo Ohuchi

    JOURNAL OF MOLECULAR HISTOLOGY   48 ( 1 )   29 - 39   2017.2

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    DOI： 10.1007/s10735-016-9703-2

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  • 抗酸化物質グルタチオンは炎症性骨破壊を促進する

    藤田 洋史, 大野 充昭, 青山 絵理子, 大内 淑代

    日本骨代謝学会学術集会プログラム抄録集   34回   206 - 206   2016.7

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  • Phytoestrogen Suppresses Efflux of the Diagnostic Marker Protoporphyrin IX in Lung Carcinoma

    Hirofumi Fujita, Keisuke Nagakawa, Hirotsugu Kobuchi, Tetsuya Ogino, Yoichi Kondo, Keiji Inoue, Taro Shuin, Toshihiko Utsumi, Kozo Utsumi, Junzo Sasaki, Hideyo Ohuchi

    CANCER RESEARCH   76 ( 7 )   1837 - 1846   2016.4

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    DOI： 10.1158/0008-5472.CAN-15-1484

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  • マウス頭蓋冠におけるリポポリサッカリドによる骨破壊とグルタチオンの効果

    藤田 洋史, 大野 充昭, 青山 絵理子, 荻野 哲也, 近藤 洋一, 大内 淑代

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [1LBA049] - [1LBA049]   2015.12

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    Language：Japanese   Publisher：(公社)日本生化学会  

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  • Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro

    Hirofumi Fujita, Masanao Yamamoto, Tetsuya Ogino, Hirotsugu Kobuchi, Naoko Ohmoto, Eriko Aoyama, Takashi Oka, Tohru Nakanishi, Keiji Inoue, Junzo Sasaki

    CELL BIOCHEMISTRY AND FUNCTION   32 ( 1 )   77 - 86   2014.1

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    DOI： 10.1002/cbf.2974

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  • Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4

    Masanao Yamamoto, Hirofumi Fujita, Naoki Katase, Keiji Inoue, Hitoshi Nagatsuka, Kozo Utsumi, Junzo Sasaki, Hideyo Ohuchi

    ACTA MEDICA OKAYAMA   67 ( 3 )   153 - 164   2013.6

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    DOI： 10.18926/AMO/50408

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  • Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation Reviewed

    Hirotsugu Kobuchi, Koko Moriya, Tetsuya Ogino, Hirofumi Fujita, Keiji Inoue, Taro Shuin, Tatsuji Yasuda, Kozo Utsumi, Toshihiko Utsumi

    PLOS ONE   7 ( 11 )   e50082   2012.11

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    DOI： 10.1371/journal.pone.0050082

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  • 炎症性サイトカインによる破骨細胞分化とビタミンＥ及びその誘導体の作用

    ビタミンE 研究の進歩   15   2012

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  • Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells

    Tetsuya Ogino, Hirotsugu Kobuchi, Kazuaki Munetomo, Hirofumi Fujita, Masanao Yamamoto, Toshihiko Utsumi, Keiji Inoue, Taro Shuin, Junzo Sasaki, Masayasu Inoue, Kozo Utsumi

    MOLECULAR AND CELLULAR BIOCHEMISTRY   358 ( 1-2 )   297 - 307   2011.12

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    DOI： 10.1007/s11010-011-0980-5

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  • Effect of Risedronate on Osteoblast Differentiation, Expression of Receptor Activator of NF-kappa B Ligand and Apoptosis in Mesenchymal Stem Cells Reviewed

    Hirofumi Fujita, Kazuko Kurokawa, Tetsuya Ogino, Mio Ono, Masanao Yamamoto, Takashi Oka, Tohru Nakanishi, Naoya Kobayashi, Noriaki Tanaka, Tomohiro Ogawa, Etsuko Suzaki, Kozo Utsumi, Junzo Sasaki

    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY   109 ( 2 )   78 - 84   2011.8

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    DOI： 10.1111/j.1742-7843.2011.00685.x

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  • Effect of Risedronate on Osteoblast Differentiation, Expression of Receptor Activator of NF-kappa B Ligand and Apoptosis in Mesenchymal Stem Cells

    Hirofumi Fujita, Kazuko Kurokawa, Tetsuya Ogino, Mio Ono, Masanao Yamamoto, Takashi Oka, Tohru Nakanishi, Naoya Kobayashi, Noriaki Tanaka, Tomohiro Ogawa, Etsuko Suzaki, Kozo Utsumi, Junzo Sasaki

    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY   109 ( 2 )   78 - 84   2011.8

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    DOI： 10.1111/j.1742-7843.2011.00685.x

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  • alpha-Tocopheryl succinate induces rapid and reversible phosphatidylserine externalization in histiocytic lymphoma through the caspase-independent pathway Reviewed

    Hirofumi Fujita, Daisuke Shiva, Toshihiko Utsumi, Tetsuya Ogino, Tomohiro Ogawa, Koichi Abe, Tatsuji Yasuda, Kozo Utsumi, Junzo Sasaki

    MOLECULAR AND CELLULAR BIOCHEMISTRY   333 ( 1-2 )   137 - 149   2010.1

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    DOI： 10.1007/s11010-009-0214-2

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  • Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937

    Takashi Amo, Noriaki Kawanishi, Masataka Uchida, Hirofumi Fujita, Eri Oyanagi, Toshihiko Utsumi, Tetsuya Ogino, Keiji Inoue, Taro Shuin, Kozo Utsumi, Junzo Sasaki

    CELL BIOCHEMISTRY AND FUNCTION   27 ( 8 )   503 - 515   2009.12

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    DOI： 10.1002/cbf.1603

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  • Regulation of 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation in Human Urothelial Carcinomas Reviewed

    Keiji Inoue, Takashi Karashima, Masayuki Kamada, Taro Shuin, Atsushi Kurabayashi, Mutsuo Furihata, Hirofumi Fujita, Kozo Utsumi, Junzo Sasaki

    PATHOBIOLOGY   76 ( 6 )   303 - 314   2009

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    DOI： 10.1159/000245896

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  • 5-Aminolevulinic acid依存性のprotoporphyrine IX蓄積によるガン細胞の診断と治療に関する研究−Tocopherylsuccinateによる増強作用

    藤田洋史, 沖村祐弥, 荻野哲也, 保田立二, 阿部浩一, 内海耕慥, 佐々木順造

    ビタミンE 研究の進歩   13   2009

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  • alpha-lipoic acid suppresses 6-hydroxydoparnine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1

    Hirofumi Fujita, Masahiko Shiosaka, Tetsuya Ogino, Yuya Okimura, Toshihiko Utsumi, Eisuke F. Sato, Reiko Akagi, Masayasu Inoue, Kozo Utsumi, Junzo Sasaki

    BRAIN RESEARCH   1206   1 - 12   2008.4

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    DOI： 10.1016/j.brainres.2008.01.081

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  • Flow cytometric analysis of Ca2+-induced membrane permeability transition of isolated rat liver mitochondria

    Teruo Umegaki, Yuya Okimura, Hirofumi Fujita, Hiromi Yano, Jitsuo Akiyama, Masayasu Inoue, Kozo Utsumi, Junzo Sasaki

    Journal of Clinical Biochemistry and Nutrition   42 ( 1 )   35 - 44   2008.1

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    DOI： 10.3164/jcbn.2008006

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  • Regulation of 5-aminolevulinic acid-dependent protoporphyrin IX accumulations in human histiocytic lymphoma U937 cells

    Yuya Okimura, Hirofumi Fujita, Tetsuya Ogino, Keiji Inoue, Toro Shuin, Hiromi Yano, Tatsuji Yasuda, Masayasu Inoue, Kozo Utsumi, Junzo Sasaki

    Physiological Chemistry and Physics and Medical NMR   39 ( 1 )   69 - 82   2007

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  • Immunoregulation and apoptosis induction of nitric oxide in the human mixed lymphocytes culture

    T. Fujiwara, H. Fujita, Y. Okimura, K. Utsumi

    TRANSPLANTATION PROCEEDINGS   38 ( 10 )   3211 - 3213   2006.12

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    DOI： 10.1016/j.transproceed.2006.10.170

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  • Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway

    Hirofumi Fujita, Tetsuya Ogino, Hirotsugu Kobuchi, Takuzo Fujiwara, Hiromi Yano, Jitsuo Akiyama, Kozo Utsumi, Junzo Sasaki

    BRAIN RESEARCH   1113   10 - 23   2006.10

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    DOI： 10.1016/j.brainres.2006.06.079

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  • 4-hydroxy-3,5,3',4'-tetrachlorobiphenyl induced membrane permeability transition in isolated rat liver mitochondria

    Hirofumi Fujita, Yuya Okimura, Toshihiko Utsumi, Shigeyuki Kitamura, Hiroaki Kuroki, Takemi Otsuki, Junzo Sasaki, Akihiko Kashiwagi, Kozo Utsumi

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   38 ( 3 )   167 - 175   2006.5

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    DOI： 10.3164/jcbn.38.167

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  • アポトーシスとミトコンドリア -神経細胞を加味して-

    藤田洋史, 小渕浩嗣, 内海耕慥

    Clinical Neuroscience   24(6), 643-646   2006

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  • Mechanism and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cells

    S Muranaka, H Fujita, T Fujiwara, T Ogino, EF Sato, J Akiyama, Imada, I, M Inoue, K Utsumi

    ANTIOXIDANTS & REDOX SIGNALING   7 ( 9-10 )   1367 - 1376   2005.9

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    DOI： 10.1089/ars.2005.7.1367

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  • Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B Reviewed

    H Fujita, T Utsumi, S Muranaka, T Ogino, H Yano, J Akiyama, T Yasuda, K Utsumi

    BIOCHEMICAL PHARMACOLOGY   69 ( 12 )   1773 - 1784   2005.6

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    DOI： 10.1016/j.bcp.2005.03.006

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  • A possible site of superoxide generation in the complex I segment of rat heart mitochondria

    ST Ohnishi, T Ohnishi, S Muranaka, H Fujita, H Kimura, K Uemura, K Yoshida, K Utsumi

    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES   37 ( 1 )   1 - 15   2005.2

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    DOI： 10.1007/s10863-005-4117-y

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  • The response of human T lymphocytes against alloantigens following fas-mediated activation-induced cell death

    T Fujiwara, H Fujita, S Muranaka, K Utsumi, S Kusaka, K Hamazaki

    TRANSPLANTATION PROCEEDINGS   37 ( 1 )   46 - 48   2005.1

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    DOI： 10.1016/j.transproceed.2004.12.244

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  • 羅布麻抽出物（ベネトロン）の抗酸化作用とその解析 Reviewed

    藤田洋史, 沖村祐弥, 内海俊彦

    医学と薬学   54   491 - 503   2005

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  • Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: Dependency on reactive oxygen species, Akt, Bid, cytochrome c, and caspase pathway

    A Inoue, S Muranaka, H Fujita, T Kanno, H Tamai, K Utsumi

    FREE RADICAL BIOLOGY AND MEDICINE   37 ( 8 )   1290 - 1299   2004.10

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    DOI： 10.1016/j.freeradbiomed.2004.07.003

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  • Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells

    S Muranaka, T Kanno, H Fujita, H Kobuchi, J Akiyama, T Yasuda, K Utsumi

    FREE RADICAL RESEARCH   38 ( 6 )   613 - 621   2004.6

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    DOI： 10.1080/10715760410001694035

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  • アクトネル（リセドロネート）によるU937細胞のアポトーシスとその機構 Reviewed

    藤田洋史, 菅野智子, 内海俊彦, 村中式部, 藤原拓造, 内海耕慥

    医学と薬学   51   697 - 710   2004

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  • Mitochondrial swelling and cytochrome c release: Sensitivity to cyclosporin A and calcium Reviewed

    Tomoko Kanno, Hirofumi Fujita, Shikibu Muranaka, Hiromi Yano, Toshihiko Utsumi, Tamotsu Yoshioka, Masayasu Inoue, Kozo Utsumi

    Physiological Chemistry and Physics and Medical NMR   34 ( 2 )   91 - 102   2002

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Books

  • CATALASE GENE MUTANT MICE: ACATALASEMIC AND HYPOCATALASEMIC MICE.

    Advances in Medicine and Biology.  2013 

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MISC

  • 網膜色素上皮細胞におけるレーバー先天黒内障16型原因遺伝子KCNJ13のノックアウトは酸化ストレス感受性を高め細胞死を誘導する

    藤田洋史, 神崎勇希, 神崎勇希, 佐藤恵太, 細川海音, 松前洋, 森實祐基, 森實祐基, 大内淑代

    日本酸化ストレス学会学術集会プログラム・抄録集   76th   2023

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  • Clec4a2/Clec4dダブルノックアウトは破骨細胞の分化を促進する

    藤田洋史, 高橋憲司, 田井雄馬, 上田悠都, 大内淑代

    日本生化学会大会(Web)   96th   2023

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  • カリウムチャネル遺伝子KCNJ13ノックアウト網膜色素上皮では酸化ストレスにより細胞死を生じる

    大内淑代, 神崎勇希, 神崎勇希, 藤田洋史, 佐藤恵太, 細川海音, 松前洋, 森實祐基, 森實祐基

    日本先天異常学会学術集会プログラム・抄録集   63rd   2023

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  • CRISPR-Cas9を用いたC-type lectin receptor多重変異マウスの作製の試み-破骨細胞分化における分子機能解明を目指して-

    藤田洋史, 田井雄馬, 上田悠都, 大内淑代

    日本解剖学会総会・全国学術集会抄録集(CD-ROM)   128th   2023

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  • Attempt to generate C-type lectin receptor Clec4a2/Clec4d/Clec5a mutant mice

    藤田洋史, 田井雄馬, 上田悠都, 大内淑代

    日本分子生物学会年会プログラム・要旨集(Web)   45th   2022

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  • グルタチオンによる破骨細胞形成促進にシステイニルロイコトリエン受容体CysLTR1は関与しない

    藤田洋史, 土生田宗憲, 服部高子, 久保田聡, 大内淑代

    日本酸化ストレス学会学術集会プログラム・抄録集   75th (CD-ROM)   2022

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  • Cysltr1変異はリポポリサッカリドによるマウス頭蓋冠の骨破壊に影響しない

    藤田洋史, 土生田宗憲, 服部高子, 久保田聡, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   127th (CD-ROM)   2022

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  • Dkk3(REIC)ノックアウトマウス副腎の形態学的解析

    土生田宗憲, 藤田洋史, 佐藤恵太, 板東哲哉, 公文裕巳, 大内淑代

    日本解剖学会総会・全国学術集会抄録集(CD-ROM)   127th   2022

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  • レーバー先天性黒内障16病態モデルiPS-RPEの作製と解析

    大内淑代, 神崎勇希, 神崎勇希, 藤田洋史, 佐藤恵太, 細川海音, 松前洋, 松前洋, 白神史雄, 森實祐基

    日本先天異常学会学術集会プログラム・抄録集   61st (CD-ROM)   2021

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  • Cysltr1遺伝子変異は破骨細胞分化と炎症性骨破壊に影響しない

    藤田洋史, 土生田宗憲, 大野充昭, 大橋俊孝, 服部高子, 久保田聡, 大内淑代

    日本生化学会大会(Web)   94th   2021

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  • ゲノム編集Fgf10モザイク変異体の遺伝子型と表現型解析

    土生田宗憲, 泰江章博, 鈴木賢一, 藤田洋史, 高山鮎子, 佐藤恵太, 板東哲哉, 親泊政一, 田中栄二, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   125th   2020

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  • Fgf10モザイク変異体における肺表現型および下肢帯表現型の形態学的解析

    土生田宗憲, 泰江章博, 鈴木賢一, 高山鮎子, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代

    日本先天異常学会学術集会プログラム・抄録集   60th   2020

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  • KCNJ13遺伝子欠損がヒト多能性幹細胞由来網膜色素上皮細胞の貪食能に及ぼす影響

    神崎勇希, 神崎勇希, 藤田洋史, 佐藤恵太, 細川海音, 松前洋, 白神史雄, 森實祐基, 大内淑代

    日本眼科学会雑誌   124   2020

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  • Cysltr1ノックアウトマウスを用いたシステイニルロイコトリエン受容体1の骨粗鬆症モデルにおける機能解明

    藤田洋史, 安藤碧, 大野充昭, 土生田宗憲, 服部高子, 久保田聡, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   125th   2020

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  • Fgf10ゲノム編集モザイク変異マウスの肺と四肢の表現型解析

    土生田宗憲, 泰江章博, 鈴木賢一, 鈴木賢一, 藤田洋史, 佐藤恵太, 河野仁美, 高山鮎子, 板東哲哉, 宮石智, 親泊政一, 田中栄二, 大内淑代

    日本分子生物学会年会プログラム・要旨集(Web)   43rd   2020

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  • 神経網膜形成における転写因子Lhx1の下流遺伝子の機能解析

    衣畑俊希, 佐藤恵太, 藤田洋史, 板東哲哉, 濃野勉, 大内淑代

    日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

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  • REIC/Dickkopf3(Dkk3)の副腎における機能解析

    土生田宗憲, 藤田洋史, 佐藤恵太, 板東哲哉, 公文裕巳, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   2019

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  • 破骨細胞におけるロイコトリエン系の機能解析:CRISPR-Cas9を用いたcysltr1ノックアウトマウスの作製

    藤田洋史, 土生田宗憲, 服部高子, 久保田聡, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   124th   2019

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  • グルタチオンは破骨細胞形成と炎症性骨破壊を促進する

    藤田洋史, 越智正彦, 大野充昭, 青山絵理子, 荻野哲也, 大内淑代

    日本酸化ストレス学会学術集会プログラム・抄録集   72nd   2019

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  • 破骨細胞におけるロイコトリエン系の機能解明 CRISPR-Cas9を用いたalox5apノックアウトマウスの作製

    藤田 洋史, 長尾 僚祐, 土生田 宗憲, 服部 高子, 久保田 聡, 大内 淑代

    日本生化学会大会プログラム・講演要旨集   91回   [3P - 234]   2018.9

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    J-GLOBAL

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  • Congenital eye anomalies: More mosaic than thought? Reviewed International journal

    Ohuchi H, Sato K, Habuta M, Fujita H, Bando T

    Congenital anomalies   59 ( 3 )   56 - 73   2018.7

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    The eye is a sensory organ that primarily captures light and provides the sense of sight, as well as delivering non-visual light information involving biological rhythms and neurophysiological activities to the brain. Since the early 1990s, rapid advances in molecular biology have enabled the identification of developmental genes, genes responsible for human congenital diseases, and relevant genes of mutant animals with various anomalies. In this review, we first look at the development of the eye, and we highlight seminal reports regarding archetypal gene defects underlying three developmental ocular disorders in humans: (1) holoprosencephaly (HPE), with cyclopia being exhibited in the most severe cases; (2) microphthalmia, anophthalmia, and coloboma (MAC) phenotypes; and (3) anterior segment dysgenesis (ASDG), known as Peters anomaly and its related disorders. The recently developed methods, such as next-generation sequencing and genome editing techniques, have aided the discovery of gene mutations in congenital eye diseases and gene functions in normal eye development. Finally, we discuss Pax6-genome edited mosaic eyes and propose that somatic mosaicism in developmental gene mutations should be considered a causal factor for variable phenotypes, sporadic cases, and de novo mutations in human developmental disorders.

    DOI： 10.1111/cga.12304

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  • Lhx1過剰発現による二重網膜誘導モデルを用いた網膜初期発生の研究

    衣畑俊希, 佐藤恵太, 藤田洋史, 板東哲哉, 大内淑代

    日本分子生物学会年会プログラム・要旨集(Web)   41st   2018

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  • ゲノム編集Fgf10モザイク変異体の組織学的解析

    土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   123rd   2018

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  • 紫外線受容視物質オプシン5のニワトリ胚線維芽細胞における作用

    加藤睦子, 加藤睦子, 佐藤恵太, 藤田洋史, 板東哲哉, 森實祐基, 中山正, 白神史雄, 大内淑代

    日本眼科学会雑誌   122   2018

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  • Fgf10モザイク変異体における肺表現型の形態学的解析

    土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代

    日本先天異常学会学術集会プログラム・抄録集   58th   2018

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  • ゲノム編集マウスを用いた破骨細胞分化におけるロイコトリエン合成関連遺伝子の機能解析

    藤田洋史, 長尾僚祐, 土生田宗憲, 服部高子, 久保田聡, 大内淑代

    日本解剖学会総会・全国学術集会講演プログラム・抄録集   123rd   2018

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  • CRISPR/Cas9システムにより作製したモザイク変異マウスの組織学的解析

    土生田宗憲, 泰江章博, 藤田洋史, 板東哲哉, 佐藤恵太, 親泊政一, 田中栄二, 大内淑代

    日本生化学会大会(Web)   90th   2017

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  • Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum

    Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida, Hideyo Ohuchi

    PLOS ONE   11 ( 11 )   2016.11

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  • Autopsy Case of Bilateral Optic Nerve Aplasia with Microphthalmia: Neural Retina Formation Is Required for the Coordinated Development of Ocular Tissues

    Hideyo Ohuchi, Kaori Taniguchi, Satoru Miyaishi, Hitomi Kono, Hirofumi Fujita, Tetsuya Bando, Chiharu Fuchizawa, Yuko Ohtani, Osamu Ohtani

    ACTA MEDICA OKAYAMA   70 ( 2 )   131 - 137   2016.4

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  • Erythroid and megakaryocytic differentiation of K562 erythroleukemic cells by monochloramine

    T. Ogino, H. Kobuchi, H. Fujita, A. Matsukawa, K. Utsumi

    FREE RADICAL RESEARCH   48 ( 3 )   292 - 302   2014.3

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  • Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation

    Takahiro Yamashita, Katsuhiko Ono, Hideyo Ohuchi, Akane Yumoto, Hitoshi Gotoh, Sayuri Tomonari, Kazumi Sakai, Hirofumi Fujita, Yasushi Imamoto, Sumihare Noji, Katsuki Nakamura, Yoshinori Shichida

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 7 )   3991 - 4000   2014.2

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  • The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer

    Hideo Fukuhara, Keiji Inoue, Atsushi Kurabayashi, Mutsuo Furihata, Hirofumi Fujita, Kozo Utsumi, Junzo Sasaki, Taro Shuin

    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY   10 ( 4 )   399 - 409   2013.12

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  • Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma

    Keiji Inoue, Hideo Fukuhara, Atsushi Kurabayashi, Mutsuo Furihata, Masayuki Tsuda, Keisuke Nagakawa, Hirofumi Fujita, Kozo Utsumi, Taro Shuin

    CANCER SCIENCE   104 ( 6 )   765 - 772   2013.6

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  • 分葉膵に付着した消化管重複症の1例

    尾山 貴徳, 野田 卓男, 楳田 祐三, 藤 智和, 八木 孝仁, 小阪 淳, 藤田 洋史

    日本小児外科学会雑誌   49 ( 3 )   745 - 745   2013.5

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    Language：Japanese   Publisher：(NPO)日本小児外科学会  

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  • Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

    Hirotsugu Kobuchi, Koko Moriya, Tetsuya Ogino, Hirofumi Fujita, Keiji Inoue, Taro Shuin, Tatsuji Yasuda, Kozo Utsumi, Toshihiko Utsumi

    PLOS ONE   7 ( 11 )   e50082   2012.11

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  • Resveratrol Inhibited Hydroquinone-Induced Cytotoxicity in Mouse Primary Hepatocytes

    Da-Hong Wang, Yoshie Ootsuki, Hirofumi Fujita, Masahiro Miyazaki, Qinxia Yie, Ken Tsutsui, Kuniaki Sano, Noriyoshi Masuoka, Keiki Ogino

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   9 ( 9 )   3354 - 3364   2012.9

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  • A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes.

    Wang DH, Ishikawa Y, Miyazaki M, Fujita H, Tsutsui K, Sano K, Masuoka N, Ogino K

    Health   3 ( 5 )   288 - 291   2011

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  • A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes.

    Wang DH, Ishikawa Y, Miyazaki M, Fujita H, Tsutsui K, Sano K, Masuoka N, Ogino K

    Health   3 ( 5 )   288 - 291   2011

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  • セファランチンはpan-ATP binding cassette transporter inhibitorとして作用するか

    アルカロイド研究会会誌   36   79 - 84   2010

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  • 5-aminolevulinic acidによる光動力学的治療におけるferrochelataseとATP binding cassette G2のヒト尿路上皮ガンT24細胞での役割

    山本昌直, 藤田洋史, 宗友一晃, 内海俊彦, 井上啓史, 佐々木順造, 内海耕慥

    生化学   2010

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  • 5-アミノレブリン酸を利用した光力学作用によるガン細胞死の解析 : Flow cytometry を中心として

    内田 昌孝, 小柳 えり, 藤田 洋史, 井上 啓史, 内海 俊彦, 内海 耕慥, 佐々木 順造

    バイオイメージング   18 ( 2 )   200 - 201   2009.7

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  • 5-アミノレブリン酸依存性プロトポルフィリンIXを利用した癌細胞イメージングとその蓄積機構の解析

    藤田 洋史, 内田 昌孝, 小柳 えり, 井上 啓史, 内海 俊彦, 内海 耕慥, 佐々木 順造

    バイオイメージング   18 ( 2 )   198 - 199   2009.7

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  • 【欧文原著】Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by Mn2+, deferoxamine, and NOC-18 in human histiocytic lymphoma cell line U937

    Amo T, Kawanishi N, Uchida M, Fujita H, Oyanagi E, Utsumi T, Ogino T, Inoue K, Shuin T, Utsumi K, Sasaki J

    Cell Biochem Funct   27   503 - 15   2009

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  • フローサイトメーターによる微量ミトコンドリアの機能解析.

    沖村祐弥, 藤田洋史, 天羽隆, 阿部浩一, 矢野博己, 秋山實男, 内海耕慥, 佐々木順造

    ビタミンE研究の進歩XIII   11 - 18   2009

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  • Mechanism of 3-nitropropionic acid-induced membrane permeability transition of isolated mitochondria and its suppression by L-carnitine

    Makoto Nishimura, Yuya Okimura, Hirofumi Fujita, Hiromi Yano, Jintae Lee, Etsuko Suzaki, Masayasu Inoue, Kozo Utsumi, Junzo Sasaki

    CELL BIOCHEMISTRY AND FUNCTION   26 ( 8 )   881 - 891   2008.12

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  • L-Carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria Reviewed

    Eri Oyanagi, Hiromi Yano, Yasuko Kato, Hirofumi Fujita, Kozo Utsumi, Junzo Sasaki

    CELL BIOCHEMISTRY AND FUNCTION   26 ( 7 )   778 - 786   2008.10

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  • L-カルニチンは脂肪酸のβ酸化を促進してミトコンドリアの膜透過性遷移を抑制する

    小栁えり, 矢野博己, 藤田洋史, 井上正康, 内海耕慥, 佐々木順造

    医学と薬学   60 ( 2 )   227 - 237   2008

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  • Mechanism of A23187-induced apoptosis in HL-60 cells: Dependency on mitochondrial permeability transition but not on NADPH oxidase

    Noriko Kajitani, Hirotsugu Kobuchi, Hirofumi Fujita, Hiromi Yano, Takuzo Fujiwara, Tatsuji Yasuda, Kozo Utsumi

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   71 ( 11 )   2701 - 2711   2007.11

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  • フローサイトメトリーによるミトコンドリア膜透過性遷移の解析

    中川慎也, 沖村祐弥, 藤田洋史, 矢野博己, 西村眞, 梅垣輝生, 内海耕慥, 佐々木順造

    解剖学雑誌   82 ( Supplement )   255   2007.3

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  • U937細胞の5‐アミノレブリン酸依存性のプロトポルフィリンIX蓄積とその光力学的作用の機構と調節

    藤田洋史, 沖村祐弥, 荻野哲也, 西村眞, 矢野博己, 内海耕慥, 佐々木順造

    生化学   4P-0881   2007

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  • 酸化ドーパミン誘導性アポトーシスに対するAntioxidant biofactor （AOB）の阻害作用におけるGSH合成の関与.

    藤田洋史, 荻野哲也, 内海耕慥, 佐々木順造

    医学と薬学   58   417 - 424   2007

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  • α-リポ酸と細胞死

    藤田洋史, 沖村祐弥, 佐藤英介, 内海耕慥, 佐々木順造

    New Food Industry   49   29 - 35   2007

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  • Stimulation of membrane permeability transition by α-lipoic acid and its biochemical characteristics

    Sanae Aoyama, Yuya Okimura, Hirofumi Fujita, Eisuke F. Sato, Teruo Umegaki, Koichi Abe, Masayasu Inoue, Kozo Utsumi, Junzo Sasaki

    Physiological Chemistry and Physics and Medical NMR   38 ( 1 )   1 - 20   2006

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  • 6-hydroxydopamineによるPC12細胞の細胞死とα-リポ酸（ALIPURER）の抑制機構

    藤田洋史, 沖村祐弥, 青山早苗, 秋山實男, 井上俊忠, 佐藤英介, 内海耕慥, 佐々木順造

    医学と薬学   55 ( 6 )   857 - 866   2006

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  • Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: Dependency on reactive oxygen species, Akt, Bid, cytochrome c, and caspase pathway (vol 37, pg 1290, 2004)

    A Inoue, S Muranaka, H Fujita, T Kanno, H Tamai, K Utsumi

    FREE RADICAL BIOLOGY AND MEDICINE   38 ( 1 )   149 - 149   2005.1

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  • Oxidative stress underlies the mechanism for Ca2+-induced permeability transition of mitochondria

    T Kanno, EF Sato, S Muranaka, H Fujita, T Fujiwara, T Utsumi, M Inoue, K Utsumi

    FREE RADICAL RESEARCH   38 ( 1 )   27 - 35   2004.1

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  • Role of alpha-tocopherol in the regulation of mitochondrial membrane permeability transition

    T Kanno, M Yorimitsu, S Muranaka, EF Sato, M Nagano, A Inoue, M Inoue, K Utsumi

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   35 ( 1 )   7 - 15   2004

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  • 17β-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transition Reviewed

    Chosei Miyaguchi, Shikibu Muranaka, Tomoko Kanno, Hirofumi Fujita, Jitsuo Akiyama, Tamotsu Yoshioka, Tatsuji Yasuda

    Physiological Chemistry and Physics and Medical NMR   36 ( 1 )   21 - 35   2004

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  • 17β-estradiol suppresses ROS-induced apoptosis of CHO cells through inhibition of lipid peroxidation-coupled membrane permeability transition

    Chosei Miyaguchi, Shikibu Muranaka, Tomoko Kanno, Hirofumi Fujita, Jitsuo Akiyama, Tamotsu Yoshioka, Tatsuji Yasuda

    Physiological Chemistry and Physics and Medical NMR   36 ( 1 )   21 - 35   2004

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  • Role of α-tocopherol in the regulation of mitochondrial permeability transition Reviewed

    Masae Yorimitsu, Shikibu Muranaka, Eisuke F. Sato, Hirofumi Fujita, Kouichi Abe, Tatsuji Yasuda, Masayasu Inoue, Kozo Utsumi

    Physiological Chemistry and Physics and Medical NMR   36 ( 2 )   95 - 107   2004

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  • Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition Reviewed

    Makoto Nagano, Tomoko Kanno, Hirofumi Fujita, Shikibu Muranaka, Takuzo Fujiwara, Kozo Utsumi

    Physiological Chemistry and Physics and Medical NMR   35 ( 2 )   131 - 143   2003

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Presentations

  • ABCG2 siRNA導入によるがん細胞のアポトーシス誘導

    2017年度生命科学系学会合同年次大会  2017 

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  • CRISPR/Cas9システムにより作製したモザイク変異マウスの組織学的解析

    2017年度生命科学系学会合同年次大会  2017 

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  • ノックアウトマウス及びプロテオーム解析を用いたDKK3タンパク質の生理的機能の解明

    第122回日本解剖学会総会・全国学術集会  2017 

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  • 抗酸化物質グルタチオンは炎症性骨破壊を促進する

    第34回日本骨代謝学会学術集会 第3回アジア太平洋骨代謝学会議  2016 

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  • ヘム代謝制御に基づく光感受性物質protoporphyrin IX蓄積機構の研究

    第69回日本酸化ストレス学会学術集会  2016 

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  • マウス頭蓋冠における内毒素lipopolysaccharideによる骨溶解と抗酸化物質グルタチオンの作用

    第121回日本解剖学会総会・全国学術集会  2016 

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  • ヘム代謝関連遺伝子のRNAi効果による光線力学療法の改善

    第89回日本生化学会大会  2016 

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  • がん関連遺伝子Dickkopf-3(Dkk-3)の生体内における発現パターンの解析

    第57回日本組織細胞化学会総会・学術集会  2016 

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  • In vitroにおいてα-tocopherolはTNFαによる破骨細胞形成を抑制する

    第26回ビタミンE研究会  2015 

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  • In vitroにおいて内在性抗酸化物質グルタチオンは破骨細胞分化に関与する

    第33回日本骨代謝学会学術集会  2015 

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  • 成人T細胞白血病/リンパ腫(ATL)発症・進展特異的な代謝異常に関するメタボローム解析

    第55回リンパ網内系学会学術集会  2015 

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  • 癌抑制遺伝子Dkk3/REICのマウス組織における発現解析

    第56回日本組織細胞化学会総会・学術集会  2015 

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  • Comprehensive expression pattern analysis of a tumor suppressor gene, REIC/DKK3 in the mouse

    第120回日本解剖学会総会・全国学術集会  2015 

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  • Immunohistochemical analysis of opsin5, an ultraviolet-absorbing photopigment, in chicken and mouse neural tissues

    第120回日本解剖学会総会・全国学術集会  2015 

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  • Effect of glutathione on TNFα-induced osteoclast differentiation in murine bone marrow-derived macrophages

    第120回日本解剖学会総会・全国学術集会  2015 

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  • Cyclin B3 is involved in leg regeneration of the cricket Gryllus bimaculatus

    第120回日本解剖学会総会・全国学術集会  2015 

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  • マウス頭蓋冠におけるリポポリサッカリドによる骨破壊とグルタチオンの効果

    BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）  2015 

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  • TNFαによる破骨細胞分化に対する抗酸化物質グルタチオンの影響

    第87回日本生化学会大会  2014 

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  • TNFαによる破骨細胞形成とそれに対するα-トコフェロールの作用

    TNFαによる破骨細胞形成とそれに対するα-トコフェロールの作用  2014 

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  • In vitroにおいてグルタチオンはTNFαによる破骨細胞分化を促進する.

    第67回日本酸化ストレス学会学術集会  2014 

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  • TNFαによる破骨細胞形成と活性酸素生成に対する骨髄間葉系幹細胞の作用.

    第119回日本解剖学会総会・全国学術集会  2014 

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  • In vitroにおけるTNFαによる破骨細胞形成促進とグルタチオンの効果

    第32回日本骨代謝学会学術集会  2014 

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  • アミノレブリン酸を用いた光線力学的作用におけるABCトランスポーターG2阻害の効果

    第4回ポルフィリン‐ALA学会年会  2014 

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  • マウス骨髄細胞培養系におけるTNFαによる破骨細胞形成と骨髄間葉系幹細胞によるその抑制効果

    第86回日本生化学会大会  2013 

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  • Sensitive detection and cell death induced by ALA-mediated photodynamic actions in adult T-cell leukemia/lymphoma cells

    第72回日本癌学会  2013 

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  • TNFαによる破骨細胞形成に対する脂溶性抗酸化物質の効果

    第118回日本解剖学会総会・全国学術集会  2013 

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  • Sensitive detection and apoptotic cell death induction of adult T-cell leukemia/lymphoma (ATL) cells with photodynamic actions

    The16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV 2013.  2013 

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  • 骨芽細胞分化培養に伴う石灰化と活性酸素の関与

    第65回日本酸化ストレス学会学術集会  2012 

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  • 骨芽細胞分化培養に伴う石灰化におけるネクローシス細胞と活性酸素の関与

    第30回日本骨代謝学会  2012 

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  • Apoptotic cell death induced by 5-aminolevulinic acid-mediated photodynamic actions in adult T-cell leukemia/lymphoma (ATL) cells

    The 71st Annual Meeting of the Japanese Cancer Association  2012 

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  • 骨髄間葉系幹細胞の骨芽細胞分化誘導に伴う石灰化機構の解析 -細胞死と活性酸素を中心として-

    日本解剖学会第67回中国・四国支部学術集会  2012 

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  • 骨髄間葉系幹細胞のosteogenic cultureによる細胞死仲介性石灰化と活性酸素の関与

    第85回日本生化学会大会  2012 

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  • 骨髄間葉系幹細胞のOsteogenic cultureにおける活性酸素仲介性細胞死と石灰化の関係

    第117回日本解剖学会総会・学術集会  2011 

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  • Dead cells promote calcification of mesenchymal stem cell-derived osteoblasts in vitro

    第116回日本解剖学会総会・全国学術集会  2011 

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  • 初代培養肝細胞におけるヒドロキノンの影響とレスベラトロールの抑制効果

    第82回日本衛生学会学術総会  2011 

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  • 低カタラーゼ活性マウスの初代培養肝細胞を用いた環境有害物質評価法の開発

    第81回日本衛生学会学術総会  2011 

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  • 炎症性サイトカインによる破骨細胞分化とビタミンＥ及びその誘導体の作用

    第22回ビタミンE研究会  2011 

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  • In vitroにおいて死細胞は骨髄間葉系幹細胞由来骨芽細胞による石灰化を促進する

    第５２回日本生化学会中国・四国支部例会  2011 

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  • がん細胞のプロトポルフィリンⅨ蓄積におけるABCG2の役割

    第５２回日本生化学会中国・四国支部例会  2011 

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  • 骨髄間葉系幹細胞による破骨細胞形成の抑制とビスホスフォネートによるその阻害機構の解析

    第５２回日本生化学会中国・四国支部例会  2011 

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  • 骨髄間葉系幹細胞の骨芽細胞分化誘導に伴う細胞死と石灰化の機構解析

    第84回日本生化学会大会  2011 

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  • 骨髄間葉系幹細胞による破骨細胞形成の抑制とビスホスフォネートによるその阻害機構の解析

    第84回日本生化学会大会  2011 

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  • 炎症性サイトカインによる破骨細胞形成に対するビタミンＥ及びその誘導体の作用の解析

    第14回Vitamin E Update Forum  2011 

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  • Effect of α-tocopherol and its derivative in TNFα-induced osteoclastogenesis in vitro

    The 5th Biennial Meeting of Society for Free Radical Research-Asia  2011 

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  • Genisteinは薬物排出タンパク質ABCG2の機能を阻害してがん細胞のALA依存性PpIX蓄積を増大させる

    第53回日本生化学会中国・四国支部例会  2011 

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  • In vitroにおける骨髄間葉系幹細胞の骨芽細胞分化に伴う石灰化には細胞死が関与する

    第29回日本骨代謝学会  2011 

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  • カタラーゼ活性の異なるマウスの初代培養肝細胞に及ぼすヒドロキノンの影響

    第８回日本予防医学学会  2010 

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  • TNF-αによる破骨細胞分化に対するヒト間葉系幹細胞とリセドロネートの影響

    第83回日本生化学会大会  2010 

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  • Role of ferrochelatase and ATP binding cassette G2 in the mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in human urothelial cancer T24 cell line

    第83回日本生化学会大会  2010 

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  • 間葉系幹細胞における骨粗鬆症治療薬リセドロネートの骨芽細胞分化とRANKL発現への影響

    第115回日本解剖学会総会全国学術集会  2010 

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  • 炎症性サイトカイン誘導性破骨細胞分化へのヒト間葉系幹細胞の作用とそれに対するビスフォスフォネートの影響

    日本解剖学会第65回中国・四国支部学術集会  2010 

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  • 間葉系幹細胞の骨芽細胞分化に伴う石灰化における細胞死の関与

    第83回日本生化学会大会  2010 

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  • The suppression of inflammatory stimuli-induced osteoclast differentiation by human mesenchymal stem cell and the action of bisphosphonate

    第28回日本骨代謝学会学術集会  2010 

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  • INHIBITION OF ATP-BINDING CASSETTE TRANSPORTER G2 INCREASED MITOCHONDRIAL LOCALIZATION OF PPIX IN ALA TREATED CELLS AND ENHANCED THEIR APOPTOTIC CELLBY PHOTODYNAMIC TREATMENT

    OzBio2010 Combined Conference  2010 

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  • セファランチンはpan-ATP binding cassette transporter inhibitor として作用するか？

    第36回アルカロイド研究会  2010 

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  • 5-Aminolevulinic acid依存性protoporphyrin IX蓄積に於けるABC transporterの機能と光動力学作用

    第63回日本酸化ストレス学会学術集会  2010 

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  • 低カタラーゼ活性マウスの初代培養肝細胞を用いた環境化学物質評価法の開発

    第80回日本衛生学会学術総会  2010 

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  • 5-Aminolevulinic acidを利用した光力学的治療ではABCG2が細胞内protoporphyrin IXの蓄積や局在性に関与し細胞障害効果を支配する

    第51回日本生化学会中国四国支部例会  2010 

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  • ビタミンEサクシネートによるホスファチジルセリンの細胞表面転移の解析

    第20回ビタミンE研究会  2009 

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  • 5-アミノレブリン酸を利用した光力学作用によるガン細胞死の解析-Flow cytometryを中心として-

    第18回バイオイメージング学術集会  2009 

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  • Active form of caspase-3 binds to actin cytoskeletal structure in apoptosis

    第82回日本生化学会  2009 

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  • αトコフェロールサクシネートによる細胞膜ホスファチジルセリンの細胞表面転移作用と細胞死の機構

    第12回Vitamin E Update Forum  2009 

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  • 5-アミノレブリン酸依存性プロトポルフィリンIXを利用した癌細胞イメージングとその蓄積機構の解析

    第18回バイオイメージング学術集会  2009 

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  • PC12細胞における6-Hydroxydopamine誘導性アポトーシスには細胞内鉄イオンが関与する

    第62回日本酸化ストレス学会学術集会  2009 

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  • Involvement of caspase-dependent and -independent cell death pathways in 5-ALA-mediated photodynamic treatment in human histiocytic lymphoma cell line U937

    21st IUBMB International Congress  2009 

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  • Etoposideによるアポトーシスにおける活性型カスパーゼ３の細胞内局在-特に細胞骨格構造との結合について

    第50回日本生化学会中国・四国支部例会  2009 

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  • 間葉系幹細胞の骨芽細胞分化とそれに対するリセドロネートの作用

    第50回日本生化学会中国・四国支部例会  2009 

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  • Regulatory mechanism of protopolphyrine IX accumulation in 5-aminolevulinic acid treated U937 cells

    第82回日本生化学会  2009 

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  • 骨粗鬆症治療薬リセドロネートの間葉系幹細胞に対する作用-骨芽細胞分化を中心として-

    第82回日本生化学会  2009 

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  • Apoptosis like- and reversible-externalization of phosphatidylserine by alpha-tocopherylsuccinate in U937 cells

    第81回日本生化学会大会  2008 

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  • Effect of nitrogen containing bisphosphonate on osteoblast differentiation of rat mesenchymal stem cell.

    第81回日本生化学会大会  2008 

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  • U937細胞の5-aminolevulinic acidによるプロトポルフィリン合成とその光力学的細胞毒性の機構解析

    第61回日本酸化ストレス学会  2008 

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  • 間葉系幹細胞の骨芽細胞分化に対するリセドロネートの影響

    第5回ビスフォスフォネートUpdate  2008 

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  • アポトーシス様フォスファチジルセリンの細胞膜表面への可逆的転移とその機構

    第49回日本生化学会中国・四国支部例会  2008 

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  • 5-アミノレブリン酸依存性光力学的細胞障害に対するAntioxidant biofactor（AOB）の影響

    第8回AOB研究会  2008 

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  • U937細胞の5-アミノレブリン酸によるプロトポルフィリンIX合成とその光力学的作用の機構解析

    第113回日本解剖学会総会全国学術集会  2008 

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  • L-carnitine suppresses fatty acid-induced mitochondrial membrane permeability transition

    第81回日本生化学会大会  2008 

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  • Mechanism of U937 cell death by 5-aminolevulinic acid mediated photodynamic treatment and its enhancement by Fe2+-chelator and ferrochelatase inhibitors

    第81回日本生化学会大会  2008 

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  • フローサイトメーターによる微量ミトコンドリアの解析

    第18回ビタミンE研究会  2007 

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  • フローサイトメトリーによるミトコンドリア膜透過性遷移の解析

    第112回日本解剖学会総会･全国学術集会  2007 

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  • ミトコンドリアの代謝機能と細胞の生死

    平成19年度日本生化学会近畿支部シンポジウム  2007 

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  • 尿路上皮癌における5-アミノレブリン酸に基づくプロトポルフィリンIX生合成とその制御

    第45回日本癌治療学会  2007 

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  • PC12 細胞の6-OHDA誘導アポトーシスはαリポ酸のグルタチオン合成促進により抑制される

    日本過酸化脂質・フリーラジカル学会  2007 

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  • 5-アミノレブリン酸依存性プロトポルフィリンの蓄積機構-ポルフィリンによるガン診断･治療の基礎的研究として-

    第18回中国･四国生体ラジカル研究会  2007 

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  • PC12細胞の6-OHDAによる活性酸素生成とアポトーシスはαリポ酸のグルタチオン合成促進作用により抑制される

    第48回日本生化学会中国・四国支部例会  2007 

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  • Suppression of 6-hydroxydopamine-induced apoptosis by antioxidant biofactor (AOB) through the stimulation of glutathione synthesis in PC12 cells

    The 7th society of study for AOB  2007 

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  • リポ酸による抗アポトーシス作用におけるGSH合成経路の関与

    第112回日本解剖学会総会･全国学術集会  2007 

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  • Role of a-lipoic acid on mitochondrial functions, redox metabolism and apoptosis of cells

    International Conference on Food Factors for health promotion (ICoFF 2007)  2007 

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  • 5-アミノレブリン酸を用いたプロトポルフィリンIX合成とその光力学的細胞毒性の分子機構解析

    第62回日本解剖学会中国四国支部学術集会  2007 

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  • Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX-accumulation and its photodynamic action in U937 cells

    International Conference on Food Factors for health promotion (ICoFF 2007)  2007 

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  • U937細胞の5-アミノレブリン酸依存性のプロトポルフィリンIX蓄積とその光力学的作用の機構と調節

    第80回日本生化学会  2007 

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  • 6-hydroxydopamineによるPC12細胞のアポトーシスとαリポ酸によるその抑制と機構

    第17回中国四国生体ラジカル研究会  2006 

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  • A23187誘導のアポトーシスにおける活性酸素生成とミトコンドリア 膜透過性遷移（MPT）の関与

    第17回中国四国生体ラジカル研究会  2006 

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  • 3-Nitropropionic acid induces membrane permeability transition of mitochondria by a L-carnitine-inhibitable mechanism

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress  2006 

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  • 細胞死とαリポ酸

    第１回αリポ酸研究会  2006 

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  • 骨粗鬆症治療薬リセドロネートで誘導されるU937細胞のアポトーシスでの生存シグナルキナーゼを中心とした解析

    第111回日本解剖学会総会・全国学術集会  2006 

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  • 6-hydroxydopamineによるPC12細胞のアポトーシスとそれに対する抗酸化剤AOBの効果

    第6回AOB研究会  2006 

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  • 6-OHDAによるPC12細胞アポトーシスのα-リポ酸による抑制とその機構

    第３０回日本過酸化脂質フリーラジカル学会  2006 

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  • α-リポ酸による6-hydroxydopamine誘導性アポトーシスの抑制にはグルタチオンが関与する

    第61回日本解剖学会中四国支部会  2006 

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  • Cyclosporin A dose not interfere with steroid-induced apoptosis of alloantigen-activated T lymphocytes.

    12th ESOT Congress 2005 & 14th ETCO Congress 2005  2005 

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  • 骨粗鬆治療薬リセドロネートによるU937細胞のアポトーシス機構

    第2回ビスフォスフォネートUpdate  2005 

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  • Enhancement of T3-induced regression of tadpole tail by 4-OH-3,5,3',4'-tetrachlorobiphenyl through MPT mechanism

    第8回環境ホルモン学会研究発表会  2005 

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  • 骨粗鬆治療薬RisedronateによるU937のアポトーシスにはRas-ERK-Bad-mitochondria経路が関係する

    第46回日本生化学会中国・四国支部例会  2005 

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  • 6-hydroxydopamineによるPC12細胞のアポトーシス誘導は活性酸素生成に依存しcAMP 感受性,脱分極非感受性過程による

    第27回日本フリーラジカル学会  2005 

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  • Mechanism and characteristics of stimuli-dependent ROS generation in undifferentiated HL-60 cells

    第77回日本生化学会大会  2004 

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  • Involvement of ERK but not Akt-pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B.

    第77回日本生化学会大会  2004 

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  • The response of human T lymphocytes against allogantigens following Fas-mediated activationﾐinduced cell death.

    XX international congress of the transplantation society.  2004 

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Awards

  • 岡山医学会賞がん研究奨励賞(林原賞・山田賞)

    2017  

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    Country：Japan

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  • 日本過酸化脂質・フリーラジカル学会(現 酸化ストレス学会)論文賞

    2007  

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  • アンチオキシダントバイオファクター研究会 奨励賞

    2007  

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  • 第46回日本生化学会中国四国支部例会 学術奨励賞

    2006  

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