Updated on 2025/06/29

写真a

 
MAKINO Takuma
 
Organization
Scheduled update Lecturer
Position
Lecturer
External link

Degree

  • 博士 ( 2019.3   岡山大学 )

Research Interests

  • 頭頸部アルミノックス治療

  • MACC1

  • 頭頸部腫瘍

  • 光免疫療法

  • 頭頸部がん

Research Areas

  • Life Science / Otorhinolaryngology

Education

  • 岡山大学大学院   医歯薬学総合研究科  

    2015.4 - 2019.3

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  • Okayama University   医学部   医学科

    1999.4 - 2005.3

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Research History

  • 岡山大学学術研究院医療開発領域   講師

    2025.2

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  • 岡山大学病院   助教

    2018.1 - 2025.1

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  • 姫路赤十字病院   副部長

    2015.6 - 2017.12

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  • 岡山大学病院   医員

    2010.4 - 2015.5

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  • 姫路聖マリア病院   医員

    2007.4 - 2010.3

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  • 新日鐵広畑病院   初期臨床研修医

    2005.4 - 2007.3

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Professional Memberships

  • THE OTO-RHINO-LARYNGOLOGICAL SOCIETY OF JAPAN

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  • JAPAN SOCIETY FOR HEAD AND NECK SURGERY

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  • 日本頭頸部癌学会

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Committee Memberships

  • 日本頭頸部外科学会   頭頸部アルミノックス治療運営委員会副委員長  

    2025.4   

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  • 日本頭頸部外科学会   頭頸部イルミノックス治療運営委員  

    2021.4   

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    Committee type:Academic society

  • 日本頭頸部外科学会   頭頸部アルミノックス治療運営委員  

    2021.4 - 2023.3   

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  • 日本頭頸部癌学会   代議員  

    2020.4   

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    Committee type:Academic society

  • 日本頭頸部癌学会   代議員  

    2020.4 - 2022.3   

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Papers

  • Adverse Reactions of Photoimmunotherapy Invited Reviewed

    Takuma Makino

    The Journal of Japan Society for Laser Surgery and Medicine   45 ( 2 )   89 - 95   2024.7

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

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  • A case of an electric toothbrush tip penetrating from the oral cavity to the submandibular gland. Reviewed International journal

    Naoki Akisada, Takuma Makino, Yuto Naoi, Yoshinori Taguchi, Yuto Moriwaki, Mizuo Ando

    Clinical case reports   12 ( 6 )   e8987   2024.6

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    This report describes a case of an electric toothbrush head being retained between the floor of the mouth and the submandibular gland following a fall. Computed tomography imaging is recommended in cases of oral cavity damage to assess tissue damage and ascertain the position of the foreign body concerning blood vessels.

    DOI: 10.1002/ccr3.8987

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  • Near-infrared photoimmunotherapy for salivary duct carcinoma Reviewed

    Takuma Makino, Yasuharu Sato, Kensuke Uraguchi, Yuto Naoi, Yujiro Fukuda, Mizuo Ando

    Auris Nasus Larynx   51 ( 2 )   323 - 327   2024.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.anl.2023.09.006

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  • Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. Reviewed International journal

    Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

    Head & neck   46 ( 5 )   1074 - 1082   2024.3

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    BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

    DOI: 10.1002/hed.27724

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  • Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment Reviewed

    Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata

    Head & Neck   46 ( 7 )   1573 - 1581   2024.3

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Background

    The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis.

    Methods

    Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed.

    Results

    Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free‐flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients.

    Conclusions

    Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

    DOI: 10.1002/hed.27712

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  • Extent of thyroidectomy and paratracheal lymph node dissection in total pharyngolaryngectomy for pyriform sinus cancer, and recurrence, survival, and postoperative hypoparathyroidism: A multicenter retrospective study Reviewed

    Yosuke Ariizumi, Nobuhiro Hanai, Takahiro Asakage, Akira Seto, Toshifumi Tomioka, Junji Miyabe, Hisashi Kessoku, Takashi Mukaigawa, Go Omura, Masanori Teshima, Daisuke Nishikawa, Yuki Saito, Yukinori Asada, Takuo Fujisawa, Takuma Makino, Hiroshi Nishino, Daisuke Sano, Mitsuhiko Nakahira, Kunihiko Tokashiki, Hirokazu Uemura, Tsutomu Ueda, Akihiro Sakai, Muneyuki Masuda, Takahiro Tsujikawa, Yusuke Hiei, Naoki Nishio, Hidetoshi Matsui, Naomi Kiyota, Akihiro Homma

    Head & Neck   46 ( 2 )   269 - 281   2023.11

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Background

    Total pharyngolaryngectomy (TPL) is standard treatment for hypopharyngeal cancer. However, extensive thyroidectomy and paratracheal nodal dissection (PTND) can cause hypoparathyroidism. We sought to determine the optimum extent of resection.

    Methods

    We analyzed the clinicopathological information of 161 pyriform sinus cancer patients undergoing TPL from 25 Japanese institutions. Rates of recurrence and risk factors for hypoparathyroidism, as well as incidence of pathological contralateral level VI nodal metastasis and stomal recurrence, were investigated.

    Results

    The extent of thyroidectomy and nodal dissection were not independent risk factors for recurrence. Incidences of contralateral level VI nodal involvement and stomal recurrence were 1.8% and 1.2%, respectively. Patients undergoing hemithyroidectomy/ipsilateral PTND did not develop stomal recurrence and had the lowest incidence of hypoparathyroidism. Prognosis in patients without tracheostomy prior to hemithyroidectomy/ipsilateral PTND was comparable to that with more extensive resections.

    Conclusions

    Hemithyroidectomy/ipsilateral PTND may be sufficient for pyriform sinus cancer cases without tracheostomy.

    DOI: 10.1002/hed.27572

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  • Nasopharyngeal low-grade papillary schneiderian carcinoma with cervical metastasis. Reviewed International journal

    Kensuke Uraguchi, Kenji Nishida, Takuma Makino, Seiichiro Makihara, Masahiro Tabata, Shin Kariya, Mizuo Ando

    Auris, nasus, larynx   50 ( 5 )   821 - 826   2023.10

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    Low-grade papillary Schneiderian carcinoma (LGPSC) is a rare and newly described type of cancer arising from the Schneiderian epithelium. Owing to cellular atypia, it is difficult to differentiate this type from other papillomas and malignancies. Although this condition remains unclear, it is associated with mortality and recurrence. Therefore, treating physicians should be aware of the possibility of LGPSC for prompt diagnosis and treatment. In this article, we present an additional case of nasopharyngeal LGPSC with cervical lymph node metastasis and reviewed the 14 cases reported thus far in the literature. A 76-year-old female was referred to our department for detailed examination of nasopharyngeal and cervical lymph node tumors detected by positron emission tomography-computed tomography. Based on the biopsy of the nasopharyngeal tumor, we suspected LGPSC. Considering the clinical course and pathological findings, the patient was diagnosed with cervical lymph node metastasis through neck dissection. We performed radiotherapy for the primary lesion of the nasopharynx, which led to the disappearance of the tumor. After 13 months following the radiotherapy, the patient died from a recurrence of retroperitoneal liposarcoma without the recurrence of LGPSC.

    DOI: 10.1016/j.anl.2022.12.010

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  • Application of the Valsalva maneuver to prevent adhesion and deformity after hypopharyngeal endoscopic submucosal dissection. Reviewed International journal

    Hironao Sato, Kenta Hamada, Makoto Abe, Takuma Makino, Yoshiro Kawahara

    Gastrointestinal endoscopy   98 ( 2 )   254 - 256   2023.8

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    DOI: 10.1016/j.gie.2023.02.029

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  • Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia. Reviewed International journal

    Makoto Abe, Yoshiro Kawahara, Yuka Obayashi, Yuki Baba, Kenta Hamada, Hiroyuki Sakae, Yoshiyasu Kono, Hiromitu Kanzaki, Masaya Iwamuro, Seiji Kawano, Takuma Makino, Yohei Noda, Hidenori Marunaka, Hiroyuki Okada

    Endoscopy international open   11 ( 4 )   E351-E357   2023.4

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    Background and study aims  Endoscopic submucosal dissection (ESD) is one of the most minimally invasive treatments for superficial squamous cell cancer of the pharynx. However, aspiration pneumonia (AsP) associated with postoperative deformity of the pharynx may occur. The purpose of this study was to investigate the frequency of AsP and the degree of pharyngeal deformity after pharyngeal ESD. Patients and methods  This was a retrospective observational study of patients who underwent pharyngeal ESD at Okayama University Hospital between 2006 and 2017. The degree of pharyngeal deformation was assessed using the pharyngeal deformation grade (PDG). The primary endpoint was the frequency of AsP as a long-term adverse event. Results  Among the 52 patients enrolled, nine developed aspiration pneumonia, with a 3-year cumulative incidence of 9.0 % (95 % confidence interval [CI], 3.3 %-22.0 %). There were 16, 18, 16, and two patients that had PDG 0, 1, 2, and 3, respectively. Patients with a history of radiotherapy, as a treatment of head and neck cancer (44.4 % vs. 11.6 %; P  = 0.02) and the high PDG group (PDG 2 and 3) (77.8 % vs. 25.6 %; P  = 0.005) had a significantly higher incidence of AsP. The 3-year cumulative incidence rate of AsP after ESD in the high PDG group was significantly higher than that in the low PDG group (PDG 0 and 1) (23.9 % [95 %CI, 9.2.-49.5%] vs. 0 %; P  = 0.03). Conclusions  The incidence of aspiration pneumonia in the long-term course after pharyngeal ESD was revealed. The incidence of aspiration pneumonia may be associated with pharyngeal deformity, but further studies are needed.

    DOI: 10.1055/a-2033-9707

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  • 5年の経過で増大した上咽頭形質細胞肉芽腫の1例 Reviewed

    駿河 有莉, 牧野 琢丸, 假谷 伸, 安藤 瑞生

    口腔・咽頭科   36 ( 1 )   48 - 53   2023.3

  • A Case of Radiation-Induced Osteosarcoma with RB1 Gene Alteration Treated by Skull Base Surgery and Craniofacial Reconstruction. Reviewed

    Yuki Matsuda, Yoshihiro Otani, Takao Yasuhara, Mizuo Ando, Takaya Higaki, Takuma Makino, Hiroshi Matsumoto, Tadashi Oyama, Hisakazu Nishimori, Isao Date

    Acta medica Okayama   77 ( 1 )   85 - 90   2023.2

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    A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development.

    DOI: 10.18926/AMO/64367

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  • 【咽頭癌-最新の治療戦略】転移・再発咽頭癌に対するがん光免疫療法(頭頸部アルミノックス治療)

    牧野琢丸

    医学と薬学   79 ( 12 )   1599 - 1603   2022.12

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  • Midline involvement and perineural invasion predict contralateral neck metastasis that affects overall and disease-free survival in locally advanced oral tongue squamous cell carcinoma Reviewed International journal

    Maki Akamatsu, Takuma Makino, Shinya Morita, Yohei Noda, Shin Kariya, Tomoo Onoda, Mizuo Ando, Yoshihiro Kimata, Kazunori Nishizaki, Mitsuhiro Okano, Aiko Oka, Kengo Kanai, Yoshihiro Watanabe, Yorihisa Imanishi

    Frontiers in Oncology   12   1010252 - 1010252   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Introduction

    Although patients with oral squamous cell carcinoma who develop contralateral neck metastasis (CLNM) have worse survival outcomes than those without CLNM, accurate prediction of occult CLNM in clinically negative contralateral neck (contralateral cN0) remains difficult. This study aimed to identify clinicopathological factors that could reliably predict CLNM in patients with locally advanced (clinical T3 and T4a) tongue squamous cell carcinoma (TSCC).

    Patients and methods

    The medical data of 32 patients with cT3–4a TSCC who underwent curative surgery between 2010 and 2017 were retrospectively analyzed. The correlation of clinicopathological variables with CLNM was examined using logistic regression analysis. The diagnostic performance of significant variables was evaluated using the area under the receiver operating characteristic curves (AUC). Overall survival (OS) and disease-free survival (DFS) were assessed using a Cox proportional hazards model.

    Results

    CLNM was eventually confirmed in 11 patients (34.4%). Multivariate logistic regression showed that midline involvement [odds ratio (OR) = 23.10, P = 0.017] and perineural invasion (PNI, OR = 14.96, P = 0.014) were independent predictors of CLNM. Notably, the prediction model comprising a combination of midline involvement and PNI exhibited superior diagnostic performance with an even higher OR of 80.00 (P < 0.001), accuracy of 90.3%, and AUC of 0.876. The multivariate Cox hazards model revealed independent significance of CLNM as an unfavorable prognostic factor for both OS [hazard ratio (HR) = 5.154, P = 0.031] and DFS (HR = 3.359, P = 0.038), as well as that of PNI for OS (HR = 5.623, P = 0.033).

    Conclusion

    Our findings suggest that coexisting midline involvement and PNI of the primary tumor is highly predictive of CLNM development, which independently affects both OS and DFS in patients with locally advanced TSCC. Such reliable prediction enables efficient control of CLNM by optimizing management of the contralateral cN0 neck, which will likely contribute to improved prognosis of those patients without unnecessarily compromising their quality of life.

    DOI: 10.3389/fonc.2022.1010252

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  • Candidemia in patients with head and neck cancer: mortality and a novel risk factor Reviewed International journal

    Kensuke Uraguchi, Takuma Makino, Shin Kariya, Youhei Noda, Hidenori Marunaka, Akira Doi, Kenichi Kozakura, Soshi Takao, Mizuo Ando

    Supportive Care in Cancer   30 ( 7 )   5921 - 5930   2022.7

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    PURPOSE: Candidemia is a bloodstream infection (BSI) by Candida spp. and is associated with high mortality. However, there have been few reports about BSI in head and neck cancer (HNC). We aimed to evaluate the impact of candidemia in patients with HNC and compared it with bacteremia. STUDY DESIGN: A multicenter retrospective study. METHODS: We retrospectively analyzed 83 BSI episodes in HNC (2011 to 2020) and divided them into the candidemia and bacteremia groups. We then compared the survival rate and risk factors for candidemia between the groups. RESULTS: The overall cumulative incidence (risk) of candidemia in BSI was 12 out of 83 episodes (14.5%). The 1-year mortality for the bacteremia and candidemia groups was 33.3% and 58.3%, respectively (log-rank p = 0.041). Broad-spectrum antibiotics (odds ratio [OR]: 29.5; 95% confidence interval [CI], 2.49-350), mucositis (OR 11.0; 95% CI, 1.52-80.1), and malignant wounds (OR 79.5; 95% CI 1.33-4737) were significant risk factors for candidemia in HNC. CONCLUSIONS: Candidemia causes high mortality in patients with HNC. To our knowledge, malignant wounds have not been previously reported as a risk factor for candidemia. For early diagnosis and treatment of candidemia, risk factors should be considered, and antifungal therapy started earlier.

    DOI: 10.1007/s00520-022-07010-9

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    Other Link: https://link.springer.com/article/10.1007/s00520-022-07010-9/fulltext.html

  • 【今日からの診療に役立つ ビジュアルでダイレクトに解説する体表・軟部疾患の検査&臨床画像】画像検査各論 頭蓋・顔面・頭頸部 見逃せない疾患を中心とした頸部腫瘤の鑑別診断

    秋定 直樹, 牧野 琢丸, 安藤 瑞生

    形成外科   65 ( 増刊 )   S92 - S100   2022.6

  • ANL Secondary Publication 上顎洞癌に対する動注化学放射線治療の病理学的評価

    牧野 琢丸, 橘 智靖, 假谷 伸, 松井 裕輔, 松崎 秀信, 藤本 将平, 折田 頼尚, 藤井 邦明, 平木 隆夫, 佐藤 康晴, 金澤 右, 西崎 和則

    日本耳鼻咽喉科頭頸部外科学会会報   125 ( 5 )   913 - 915   2022.5

  • 【頸部リンパ節を見直す】頸部リンパ節腫脹 鑑別の手順 頸部リンパ節腫脹の視診と触診について

    牧野琢丸

    JOHNS   38 ( 3 )   268 - 270   2022.3

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  • Resection and immediate reconstruction of two pediatric intraosseous capillary mandibular malformations Reviewed

    Hiroshi Matsumoto, Tomoyuki Ota, Sho Komagoe, Yohei Noda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa, Kohei Taniguchi, Tomoka Ikeda, Hiroyuki Yanai, Yoshihiro Kimata

    European Journal of Plastic Surgery   45 ( 5 )   831 - 839   2022.1

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s00238-021-01905-2

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    Other Link: https://link.springer.com/article/10.1007/s00238-021-01905-2/fulltext.html

  • 【新たに薬事承認・保険収載された薬剤・医療資材・治療法ガイド】頭頸部 セツキシマブサロタロカンナトリウムを用いた頭頸部イルミノックス治療

    牧野琢丸

    耳鼻咽喉科・頭頸部外科   94 ( 1 )   59 - 64   2022.1

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  • 外耳道癌治療中に発症した胆道感染症例 Reviewed

    秋定 直樹, 牧野 琢丸, 森本 光作, 佐藤 明日香, 駿河 有莉, 梶原 壮平, 浦口 健介, 大道 亮太郎, 安藤 瑞生

    頭頸部外科   31 ( 3 )   301 - 305   2022

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    Language:Japanese   Publisher:(NPO)日本頭頸部外科学会  

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  • 小児、思春期・若年がん患者に対する妊孕性温存療法 現状と改善の取り組み Reviewed

    秋定 直樹, 牧野 琢丸, 門田 伸也, 菅谷 明子, 片岡 祐子, 中塚 幹也, 安藤 瑞生

    耳鼻咽喉科臨床   114 ( 12 )   957 - 962   2022

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  • Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining Reviewed

    Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai, Yasuharu Sato

    Diagnostics   11 ( 12 )   2284 - 2284   2021.12

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    Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova et al. in 2010 and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma.

    DOI: 10.3390/diagnostics11122284

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  • Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas. Reviewed

    Hiroshi Matsumoto, Yoshihiro Kimata, Tomoyuki Ota, Narushi Sugiyama, Satoshi Onoda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa

    Acta medica Okayama   75 ( 6 )   725 - 734   2021.12

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    The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.

    DOI: 10.18926/AMO/62813

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  • PD-L1 expression in tongue squamous cell carcinoma. Reviewed

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   52 - 59   2021.3

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    PURPOSE: Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This large-scale case study aimed to analyze tongue squamous cell carcinomas (SCCs) and evaluate the correlation between PD-L1 expression and clinical prognosis. So far, this study is the largest case study on PD-L1 expression in tongue SCCs. METHODS: This is a case-control study that analyzed 121 tongue SCCs. Paraffin-embedded sections and clinical data were obtained retrospectively and immunohistochemistry with PD-L1 was performed. RESULTS: 11.6% contained ≥ 50% of PD-L1-positive cells, 57.1% of these cases had a poor prognosis with nodal metastasis. Among cases of T1/2 primary lesions with nodal metastasis, cases of high PD-L1 expression had a significantly shorter disease-free survival than cases of no PD-L1 expression (p = 0.018). The hazard ratio for high PD-L1 expression was 3.21 (95 per cent CI, 1.26-8.72) compared with no PD-L1 expression after adjusting for other factors. CONCLUSIONS: These data indicate that PD-L1 upregulation in tongue SCCs is associated with a more advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors might hence constitute potential adjuvant therapy for tongue SCCs with PD-L1 upregulation.

    DOI: 10.1007/s00795-020-00261-7

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  • Correction to: PD-L1 expression in tongue squamous cell carcinoma. Reviewed

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   68 - 68   2021.3

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  • A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue Reviewed

    Sawako Ono, Takuma Makino, Hiroyuki Yanai, Hotaka Kawai, Kiyofumi Takabatake, Keisuke Nakano, Kenji Nishida, Kohei Taniguchi, Tomohiro Toji, Hitoshi Nagatsuka, Tadashi Yoshino

    Reports   4 ( 1 )   5 - 5   2021.2

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    Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old man, and then review the report.

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  • Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion. Reviewed International journal

    Tomoyasu Tachibana, Shin Kariya, Yoji Wani, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Kuroda, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Takuma Makino, Yuko Kataoka, Kazunori Nishizaki

    Auris, nasus, larynx   48 ( 1 )   154 - 160   2021.2

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    OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

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  • Fertility Preservation Therapy Provided for Childhood, Adolescent, and Young Adult Cancer Patients —Current Status and Efforts to Improvement—,小児,思春期・若年がん患者に対する妊孕性温存療法―現状と改善の取り組み― Reviewed

    Akisada, N., Makino, T., Sugaya, A., Kataoka, Y., Ando, M., Monden, N., Nakatsuka, M.

    Practica Oto-Rhino-Laryngologica   114 ( 12 )   2021

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  • Application of Lip Biopsy for the Histological Diagnosis of Immunoglobulin G4-Related Disease. Reviewed International journal

    Tomoyasu Tachibana, Yorihisa Orita, Yoji Wani, Yasutoshi Komatsubara, Kazunori Kuroda, Yuto Naoi, Yuka Gion, Takuma Makino, Kazunori Nishizaki, Yasuharu Sato

    Ear, nose, & throat journal   101 ( 8 )   145561320971932 - 145561320971932   2020.11

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    We describe the case of a 51-year-old woman with immunoglobulin G4-related disease (IgG4-RD) diagnosed using lip biopsy. She reported having bilateral submandibular nodules for a month. Magnetic resonance imaging showed diffuse swelling in the bilateral submandibular glands (SMGs), suggesting inflammatory changes. Laboratory data revealed an elevated level of serum IgG4. Fine needle aspiration cytology of the SMG showed a considerable number of lymphocytes with degeneration but did not demonstrate specific findings for a definitive diagnosis of IgG4-RD. Lip biopsy was performed, and a biopsy specimen from the labial salivary gland showed abundant lymphoplasmacytic infiltration with a large number of IgG4-positive cells. The patient was diagnosed with IgG4-RD based on histological and laboratory findings. Findings of further examinations revealed that the patient had autoimmune pancreatitis, confirming our diagnosis. Four months after prednisolone administration, improvement of the submandibular and pancreatic lesions was observed. One year after the initial presentation, the serum IgG4 level was normalized. In cases of IgG4-RD with salivary gland involvement, lip biopsy might be one of the options for the histological diagnosis of IgG4-RD.

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  • Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin for maxillary sinus cancer. Reviewed International journal

    Takuma Makino, Tomoyasu Tachibana, Shin Kariya, Yusuke Matsui, Hidenobu Matsuzaki, Shohei Fujimoto, Yorihisa Orita, Kuniaki Katsui, Takao Hiraki, Yasuharu Sato, Susumu Kanazawa, Kazunori Nishizaki

    Auris, nasus, larynx   47 ( 5 )   881 - 886   2020.10

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    OBJECTIVE: Since 2010, we have mainly performed surgical treatment following radiotherapy and concomitant intraarterial cisplatin (RADPLAT) for locally advanced maxillary sinus cancer (MSC). The present study investigated treatment results and pathological evaluations following RADPLAT for MSC. METHODS: Pathological response to RADPLAT was evaluated using surgical specimens. Pathological response was graded in accordance with the classification method that Shimosato reported in 1964, as grade V (no tumor cells remain in any of section), grade IV, III, II, I, and 0. Five-year overall and disease-specific survival rates were estimated using Kaplan-Meier methods. Univariate analyses of correlations between recurrence of MSC and other clinicopathological parameters were evaluated using the chi-square or Fisher's exact tests. RESULT: 19 patients were enrolled in this study, 5 patients showed T3 disease and 14 had T4 disease. One patient demonstrated local recurrence and 3 patients experienced distant metastasis. The 5-year overall survival rate was 67.1% (T3, 50.0%; T4, 69.6%), and the 5-year disease-specific survival rate was 81.9% (T3, 100%; T4, 76.0%). Histological response was categorized as grade V in 9 cases. No significant risk factors for residual cancer were identified. CONCLUSION: Our study suggested that RADPLAT not only has a low risk of side effects, but also could represent an effective procedure for locally advanced MSC by pathological evaluation. Increasing the therapeutic intensity of RADPLAT might provide an effective modality to avoid highly invasive surgery.

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  • Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. Reviewed International journal

    Yasutoshi Komatsubara, Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Kazunori Kuroda, Yuto Naoi, Yuko Kataoka, Yasuharu Sato, Shin Kariya, Kazunori Nishizaki

    Acta oto-laryngologica   140 ( 9 )   773 - 778   2020.9

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    Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

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  • AYA世代女子に発症した上顎エナメル上皮線維肉腫の1例 Reviewed

    野田 洋平, 橘 智靖, 丸中 秀格, 黒田 一範, 牧野 琢丸, 假谷 伸

    耳鼻咽喉科・頭頸部外科   92 ( 10 )   851 - 856   2020.9

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  • 耳下腺分泌癌の1経験例 Reviewed

    藤本 将平, 牧野 琢丸, 津村 宗近, 丸中 秀格, 野田 洋平, 假谷 伸, 西崎 和則

    口腔・咽頭科   33 ( 2 )   105 - 109   2020.6

  • MACC1 expression is an indicator of recurrence in early-stage glottic cancer. Reviewed International journal

    Takuma Makino, Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Soshi Takao, Hidenori Marunaka, Kentaro Miki, Naoki Akisada, Yusuke Akagi, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Japanese journal of clinical oncology   50 ( 4 )   392 - 398   2020.4

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    BACKGROUND: Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer. METHODS: Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n = 52) were immunohistochemically analyzed to explore MACC1 expression. The clinical records associated with each case were also examined. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and between-group RFS differences were assessed using the log-rank test. The multivariate analyses were evaluated using the Cox's proportional-hazard model. RESULTS: Patients were treated with only radiotherapy (RT) (n = 37, including 18 with T1 disease and 19 with T2 disease), or with chemoradiotherapy (CRT) (n = 15, including 1 with T1 disease and 14 with T2 disease). Eleven patients demonstrated local recurrence and two patients experienced cervical lymph node recurrence. Tumor specimens were MACC1-positive in 9 of the 13 (69.2%) patients with local or neck recurrence, and 7 of the 11 (63.6%) patients with local recurrence. The RFS rate of patients who were treated with only RT was significantly lower than that of patients who were treated with CRT (P = 0.0243). The RFS rate was significantly lower in cases with MACC1 expression than in those without MACC1 expression (P = 0.0003). Multivariate analysis revealed that MACC1 expression was an independent risk factor of local recurrence (P = 0.0016). CONCLUSION: MACC1 is an independent indicator of recurrence related to RFS in early-stage glottic cancer.

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  • Clinical significance of cytoplasmic IgE-positive mast cells in eosinophilic chronic rhinosinusitis Reviewed International journal

    Gion Y, Okano M, Koyama Y, Oura T, Nishikori A, Orita Y, Tachibana T, Marunaka H, Makino T, Nishizaki K, Sato Y

    Int J Mol Sci   7 ( 21 )   2020

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    Cross-linking of antigen-specific IgE bound to the high-affinity IgE receptor (FcεRI) on the surface of mast cells with multivalent antigens results in the release of mediators and development of type 2 inflammation. FcεRI expression and IgE synthesis are, therefore, critical for type 2 inflammatory disease development. In an attempt to clarify the relationship between eosinophilic chronic rhinosinusitis (ECRS) and mast cell infiltration, we analyzed mast cell infiltration at lesion sites and determined its clinical significance. Mast cells are positive for c-kit, and IgE in uncinated tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. The number of positive cells and clinicopathological factors were analyzed. Patients with ECRS exhibited high levels of total IgE serum levels and elevated peripheral blood eosinophil ratios. As a result, the number of mast cells with membranes positive for c-kit and IgE increased significantly in lesions forming NP. Therefore, we classified IgE-positive mast cells into two groups: membrane IgE-positive cells and cytoplasmic IgE-positive cells. The amount of membrane IgE-positive mast cells was significantly increased in moderate ECRS. A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. The number of cytoplasmic IgE-positive mast cells was significantly increased in moderate and severe ECRS. A positive correlation was observed between the cytoplasmic IgE-positive cells and the radiological severity score, the ratio of eosinophils in the blood, and the total IgE level. These results suggest that the process of mast cell internalization of antigens via the IgE receptor is involved in ECRS pathogenesis.

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  • An adolescent case of maxillary ameloblastic fibrosarcoma Reviewed

    Yohei Noda, Tomoyasu Tachibana, Hidenori Marunaka, Kazunori Kuroda, Takuma Makino, Shift Kariya

    Otolaryngology - Head and Neck Surgery (Japan)   92 ( 10 )   851 - 856   2020

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  • The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure. Reviewed International journal

    Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yoji Wani, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Yasuharu Sato, Kazunori Nishizaki

    Acta oto-laryngologica   139 ( 9 )   788 - 792   2019.9

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    Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

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  • KRAS mutations in tongue squamous cell carcinoma. Reviewed International journal

    Yusuke Akagi, Tomoyasu Tachibana, Yorihisa Orita, Yuka Gion, Hidenori Marunaka, Takuma Makino, Kentaro Miki, Naoki Akisada, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Acta oto-laryngologica   139 ( 7 )   647 - 651   2019.7

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    Background: p16INK4a (p16) expression in tongue cancer (TC) is reportedly not associated with human papilloma virus (HPV). Mutations of KRAS in cancer cells are most frequently observed within codon 12. However, few reports have investigated the association between KRAS mutations and p16 status in TC. Objectives: This study aimed to evaluate the influence of KRAS mutations on TC. Methods: Clinical records and surgically resected specimens of 85 TC patients were analyzed. Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13. p16 staining was performed and considered positive in cases with moderate to strong nuclear and cytoplasmic staining. Results: Positive p16 staining was observed in 10 cases (11.8%). A KRAS mutation was detected in one case (1.2%). The case with KRAS mutation showed negative p16 staining. Despite being at an early stage, the patient died of lung metastasis at 43 months from initial treatment. Conclusions and Significance: KRAS mutations are not associated with p16 expression in TC and may predict poor prognosis in TC patients. Further analysis of mutations in regions other than codons 12 and 13 of KRAS will be necessary to determine the relationship between KRAS mutations and prognosis of this disease.

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  • Spontaneous closure of traumatic tympanic membrane perforation following long-term observation. Reviewed International journal

    Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yohei Noda, Yasuharu Sato, Kazunori Nishizaki

    Acta oto-laryngologica   139 ( 6 )   487 - 491   2019.6

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    BACKGROUND: Traumatic tympanic membrane perforation (TTMP) is usually managed conservatively because most close spontaneously within a few months. Nevertheless, spontaneous closure of TTMP during long-term observation has not been well described in the literature. OBJECTIVES: The present study investigated factors associated with spontaneous closure of TTMP, and the characteristics of cases exhibiting spontaneous closure following long-term observation. MATERIALS AND METHODS: The medical records of 40 patients with TTMP who visited the authors' hospital were retrospectively reviewed. RESULTS: Spontaneous closure was observed in 27 (67.5%) patients. The healing period was <2 weeks in 6 cases, <4 weeks in 9, <3 months in 5, <6 months in 3, and ≥6 months in 4. All four cases in which spontaneous closure took ≥6 months exhibited a sign of spontaneous closure at 6 months following injury. Perforation in contact with the malleus was associated with a lower frequency of spontaneous closure. CONCLUSIONS AND SIGNIFICANCE: In TTMP, surgery should be considered in patients who exhibit perforation in contact with the malleus. However, it has also been suggested that long-term observation may be a viable treatment option when a sign of spontaneous closure is observed within 6 months following injury.

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  • Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx. Reviewed

    Makoto Abe, Masaya Iwamuro, Yoshiro Kawahara, Hiromitsu Kanzaki, Seiji Kawano, Takehiro Tanaka, Munechika Tsumura, Takuma Makino, Yohei Noda, Hidenori Marunaka, Kazunori Nishizaki, Hiroyuki Okada

    Acta medica Okayama   73 ( 2 )   109 - 115   2019.4

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    The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

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  • Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection. Reviewed International journal

    Tachibana T, Orita Y, Gion Y, Miki K, Ikegami K, Marunaka H, Makino T, Akagi Y, Akisada N, Tsumura M, Ito T, Yoshino T, Nishizaki K, Sato Y

    Acta oto-laryngologica   139 ( 1 )   80 - 84   2019.1

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    BACKGROUND: Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors. OBJECTIVES: The present study investigated the relationship between TC and human papillomavirus (HPV) infection. MATERIAL AND METHODS: Clinical records and surgically resected specimens from 86 patients (<40-years-old, n = 12; ≥40-years-old, n = 74) with TC were analyzed. Strong nuclear and cytoplasmic p16 staining was considered positive. HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11) was detected using consensus primer-mediated polymerase chain reaction. RESULTS: Strong p16 expression was observed in 10 (11.6%) patients. HPV DNA was detected in 9 (10.5%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 7). Strong p16 expression was observed more frequently among younger adults than among older adults (33.3% vs. 8.1%; p = .045). p16 staining did not correlate with the detection of HPV DNA (correlation coefficient, 0.113; p = .300). CONCLUSIONS AND SIGNIFICANCE: In TC, p16 expression was not associated with HPV infection, suggesting that it may be caused by a different mechanism.

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  • Factors that prolong the duration of recovery in acute rhinosinusitis with orbital complications. Reviewed

    Tachibana T, Kariya S, Orita Y, Nakada M, Makino T, Haruna T, Matsuyama Y, Komatsubara Y, Naoi Y, Sato Y, Nishizaki K

    Acta Otolaryngol   10   1 - 5   2019

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  • Factors that prolong the duration of recovery in acute rhinosinusitis with orbital complications. Reviewed International journal

    Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Yasuharu Sato, Kazunori Nishizaki

    Acta oto-laryngologica   139 ( 1 )   52 - 56   2019

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    BACKGROUND: Regarding prognostic factors of acute rhinosinusitis (ARS) with orbital complications, there are few studies including adult cases. OBJECTIVES: The present study aims to delineate prognostic factors of ARS with orbital complications. MATERIAL AND METHODS: We conducted a retrospective analysis of medical records of 21 patients (6 pediatric and 15 adult patients) with ARS with orbital complications. The duration of recovery was defined as the time from initial diagnosis to complete resolution of local findings and all symptoms. Orbital complications due to postoperative cysts or mycosis were excluded. RESULTS: Twenty-one patients comprised 11 males and 10 females. Chandler's classification showed group I in 4, group II in 8, and group III in 9. None of six pediatric patients required any surgical intervention, whereas five adult patients (23.8%) underwent surgical intervention. The average period of recovery was 8.1 days. In univariate analysis, the duration of recovery was significantly longer among adult cases (p < .01) and cases with Chandler's groups II-III (p = .019). In multivariate analysis, adult patients had a significantly longer duration of recovery than pediatric patients (p = .027). CONCLUSION AND SIGNIFICANCE: The present study suggested that ARS with orbital complications may have prolonged clinical course in adults.

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  • Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms. Reviewed

    Makino T, Orita Y, Tachibana T, Marunaka H, Miki K, Akisada N, Akagi Y, Usui Y, Sato Y, Yoshino T, Nishizaki K

    Acta medica Okayama   72 ( 6 )   577 - 581   2018.12

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  • Canal wall-down procedure with soft posterior meatal wall reconstruction in acquired cholesteatoma: focus on postoperative middle ear status* Reviewed International journal

    Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki

    Acta Oto-Laryngologica   138 ( 8 )   695 - 700   2018.8

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  • Prognostic factors and importance of recognition of adult croup Reviewed International journal

    Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

    Acta Oto-Laryngologica   138 ( 6 )   579 - 583   2018.6

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  • Neck metastasis in patients with T1-2 supraglottic cancer Reviewed International journal

    Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Sei-ichiro Makihara, Misato Hirai, Yuka Gion, Kana Ikegami, Kentaro Miki, Takuma Makino, Yasuyuki Noyama, Yasutoshi Komatsubara, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Auris Nasus Larynx   45 ( 3 )   540 - 545   2018.6

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  • Squamous cell carcinoma of the bilateral external auditory canals Reviewed

    Shin Kariya, Yohei Noda, Munechika Tsumura, Takuma Makino, Hidenori Marunaka, Kazunori Nishizaki

    Otolaryngology - Head and Neck Surgery (Japan)   90 ( 7 )   577 - 582   2018.6

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  • 耳後部有茎皮弁にて外耳道再建した両側性外耳道扁平上皮癌の1例 Reviewed

    假谷 伸, 野田 洋平, 津村 宗近, 牧野 琢丸, 丸中 秀格, 西崎 和則

    耳鼻咽喉科・頭頸部外科   90 ( 7 )   577 - 582   2018.6

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  • 椎周囲間隙に発生した頸部筋間脂肪腫例 Reviewed

    牧野 琢丸, 橘 智靖, 小松原 靖聡

    耳鼻咽喉科臨床   111 ( 6 )   395 - 399   2018.6

  • Laryngeal squamous cell papilloma is highly associated with human papillomavirus Reviewed International journal

    Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Kana Ikegami, Hidenori Marunaka, Seiichiro Makihara, Yasuhiko Yamashita, Kentaro Miki, Takuma Makino, Naoki Akisada, Yusuke Akagi, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Japanese Journal of Clinical Oncology   48 ( 4 )   350 - 355   2018.4

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    DOI: 10.1093/jjco/hyy009

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  • A case of intermuscular lipoma in the perivertebral space Reviewed

    Takuma Makino, Tomoyasu Tachibana, Yasutoshi Komatsubara

    Practica Oto-Rhino-Laryngologica   111 ( 6 )   395 - 399   2018

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    DOI: 10.5631/jibirin.111.395

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  • A case of a fish bone in the neck removed using CT- guided hookwire placement Reviewed

    Yasutoshi Komatsubara, Tomoyasu Tachibana, Takuma Makino, Yuto Naoi, Aiko Shimizu, Mayu Uga, Akihito Mitsumori

    Otolaryngology - Head and Neck Surgery (Japan)   89 ( 10 )   849 - 853   2017.9

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  • CTガイド下マーキングが有用であった頸部魚骨異物例 Reviewed

    小松原 靖聡, 橘 智靖, 牧野 琢丸, 直井 勇人, 清水 藍子, 宇賀 麻由, 三森 天人

    耳鼻咽喉科・頭頸部外科   89 ( 10 )   849 - 853   2017.9

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  • Sphenoid sinusitis with trismus in a child Reviewed

    Yyto Naoi, Tomoyasu Tachibana, Takuma Makino, Yasutoshi Komatsubara, Akihito Mitsumori

    Otolaryngology - Head and Neck Surgery (Japan)   89 ( 6 )   465 - 470   2017.5

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  • 開口障害を伴った小児蝶形骨洞炎例 Reviewed

    直井 勇人, 橘 智靖, 牧野 琢丸, 小松原 靖聡, 三森 天人

    耳鼻咽喉科・頭頸部外科   89 ( 6 )   465 - 469   2017.5

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  • 気管憩室を併存した甲状腺乳頭癌例 Reviewed

    橘 智靖, 折田 頼尚, 牧野 琢丸, 小松原 靖聡, 西崎 和則

    日本内分泌・甲状腺外科学会雑誌   34 ( 1 )   65 - 69   2017.3

  • Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model Reviewed International journal

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Akira Minoura, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    ONCOLOGY   93 ( 3 )   204 - 212   2017

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    DOI: 10.1159/000477301

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  • A case of herpetic tonsillitis showing tumor-like lesion Reviewed

    Aiko Shimizu, Tomoyasu Tachibana, Takuma Makino, Yuko Matsuyama, Yasutoshi Komatsubara, Yoji Wani, Tami Nagatani

    Otolaryngology - Head and Neck Surgery (Japan)   88 ( 13 )   1053 - 1056   2016.12

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  • 腫瘍様所見を呈した単純ヘルペスウイルスによる扁桃炎例 Reviewed

    清水 藍子, 橘 智靖, 牧野 琢丸, 松山 祐子, 小松原 靖聡, 和仁 洋治, 永谷 たみ

    耳鼻咽喉科・頭頸部外科   88 ( 13 )   1053 - 1056   2016.12

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  • Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma Reviewed International journal

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Hiroyuki Hanakawa, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akira Minoura, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    CANCER IMMUNOLOGY IMMUNOTHERAPY   65 ( 11 )   1401 - 1410   2016.11

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    DOI: 10.1007/s00262-016-1902-x

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  • Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings Reviewed International journal

    Hidenori Marunaka, Yorihisa Orita, Tomoyasu Tachibana, Kentaro Miki, Takuma Makino, Yuka Gion, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    ACTA OTO-LARYNGOLOGICA   136 ( 9 )   944 - 947   2016.9

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    DOI: 10.3109/00016489.2016.1164895

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  • 術前診断が困難であったCarcinoma showing thymus-like differentiation(CASTLE)の1例 Reviewed

    橘 智靖, 折田 頼尚, 牧野 琢丸, 清水 藍子, 和仁 洋治

    日本内分泌・甲状腺外科学会雑誌   33 ( 3 )   184 - 188   2016.9

  • [A Clinical Study on 64 Cases of Laryngeal Granuloma]. Reviewed

    Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Michihiro Nakada, Hidenori Marunaka, Kazunori Nishizaki

    Nihon Jibiinkoka Gakkai kaiho   119 ( 6 )   860 - 866   2016.6

  • A Case of Epithelial-myoepithelial Carcinoma of the Nasopharynx Treated by Radiation Therapy Reviewed

    Tachibana Tomoyasu, Makino Takuma, Ogawara Yuya, Matsuyama Yuko, Shimizu Aiko, Orita Yorihisa, Nishizaki Kazunori

    Practica oto-rhino-laryngologica. Suppl.   147   78 - 79   2016

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    <p>Epithelial-myoepithelial carcinoma (EMC) is a rare tumor, most commonly arising from the parotid gland. We present the case of an 80-year-old woman who presented with the chief complaint of nasal bleeding and was diagnosed as having EMC of the nasopharynx. Fiberopic endoscopy revealed a mass with erosion on the left side in the posterior wall of the nasopharynx. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a tumorous shadow limited to the nasopharynx, not extending into the surrounding tissue. Histological and immunohistochemical examination of biopsy specimens confirmed the diagnosis. Full-dose radiation therapy was administered. The tumor disappeared completely, and no evidence of recurrence or metastasis has since become apparent. We considered that radiation therapy is one of the valid treatment options for patients with inoperable EMC.</p>

    DOI: 10.5631/jibirinsuppl.147.78

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  • 下肢麻痺を認めた脊椎転移性多形腺腫の1例 Reviewed

    浦口 健介, 野田 洋平, 藤本 将平, 牧野 琢丸, 小野田 友男, 假谷 伸, 西崎 和則

    口腔・咽頭科   28 ( 2 )   177 - 182   2015.6

  • Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease. Reviewed International journal

    Hidenori Marunaka, Yorihisa Orita, Tomoyasu Tachibana, Kentaro Miki, Takuma Makino, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Modern rheumatology   28 ( 3 )   559 - 563   2015

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    DOI: 10.3109/14397595.2015.1131353

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  • Chronic rhinosinusitis patients have decreased lung function Reviewed International journal

    Shin Kariya, Mitsuhiro Okano, Takaya Higaki, Yasuyuki Noyama, Takenori Haruna, Hisashi Ishihara, Takuma Makino, Tomoo Onoda, Kazunori Nishizaki

    INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY   4 ( 10 )   828 - 833   2014.10

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    DOI: 10.1002/alr.21370

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  • 当科における上咽頭癌症例の検討 Reviewed

    牧野 琢丸, 小野田 友男, 小山 貴久, 春名 威範, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科   26 ( 2 )   203 - 206   2013.6

  • 重粒子線治療が有効であった顎下腺唾液腺導管癌(salivary duct carcinoma)の1例

    小野田 友男, 牧野 琢丸, 小山 貴久, 石原 久司, 平井 悠, 春名 威範, 假谷 伸, 西崎 和則

    口腔・咽頭科   26 ( 2 )   207 - 210   2013.6

  • 鼻副鼻腔結核の1例

    小野田 友男, 岡野 光博, 假谷 伸, 江口 元治, 野田 洋平, 牧野 琢丸, 宮武 智美, 橋本 香里, 西崎 和則, 丸中 秀格

    頭頸部外科   22 ( 3 )   273 - 276   2013.2

  • スギ・ヒノキ花粉症における初期療法の検討 エバスチン(エバステルOD錠)投与による観察研究

    小川 晃弘, 松本 亮典, 春名 威範, 西川 奈見, 黒田 一彬, 宮武 智実, 宮原 聡子, 牧野 琢丸, 黒坂 文武

    医学と薬学   66 ( 6 )   993 - 1002   2011.12

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  • Fanconi貧血に合併した舌癌の1例

    阿部 郁, 小野田 友男, 牧野 琢丸, 河野 達也, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科   24 ( 2 )   183 - 186   2011.6

  • 舌癌に対する頸部郭清の適応に関する検討

    河野 達也, 小野田 友男, 江口 元治, 牧野 琢丸, 阿部 郁, 假谷 伸, 西崎 和則

    口腔・咽頭科   24 ( 2 )   179 - 182   2011.6

  • 当院における頸部膿瘍症例の検討

    宮武 智実, 小川 晃弘, 松本 亮典, 西川 奈見, 牧野 琢丸

    日本耳鼻咽喉科感染症研究会会誌   29 ( 1 )   71 - 73   2011.5

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  • 遷延する咳嗽・咽喉頭異常感に対するトシル酸スプラタスト(IPD)の治療効果の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実

    耳鼻咽喉科免疫アレルギー   28 ( 4 )   291 - 295   2010.12

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  • 当院における入院を要した鼻出血症例の検討

    宮武 智実, 小川 晃弘, 松本 亮典, 西川 奈見, 牧野 琢丸

    姫路聖マリア病院誌   21   9 - 12   2010.12

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  • 遷延する咳嗽・咽喉頭異常感に対するトシル酸スプラタスト(IPD)の治療効果の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実

    耳鼻咽喉科免疫アレルギー   28 ( 2 )   139 - 141   2010.9

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  • 当科におけるハント症候群の検討

    牧野 琢丸, 小川 晃弘, 松本 亮典, 宮武 智実

    日本耳鼻咽喉科感染症研究会会誌   28 ( 1 )   63 - 66   2010.5

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  • 【口臭へのアプローチ】鼻・副鼻腔疾患と口臭

    小川 晃弘, 牧野 琢丸, 松本 亮典

    ENTONI   ( 108 )   28 - 34   2009.11

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  • 塩酸オロパタジン塩によるスギ花粉症初期治療群と飛散後治療群の比較検討

    牧野 琢丸, 小川 晃弘, 松本 亮典, 宮武 智実

    耳鼻咽喉科免疫アレルギー   27 ( 2 )   149 - 150   2009.9

  • BiPAPが奏効した重症SASの一例

    宮武 智実, 小川 晃弘, 松本 亮典, 牧野 琢丸, 公文 啓二, 正木 昭次, 福本 初, 岸本 朋之, 柴田 康博, 柳 文修

    姫路聖マリア病院誌   20   10 - 12   2009.8

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  • [A clinical study of admitted the review of cases of food-dependent exercise-induced anaphylaxis].

    Ryosuke Matsumoto, Teruhiro Ogawa, Takuma Makino, Mitsuhiro Okano

    Arerugi = [Allergy]   58 ( 5 )   548 - 53   2009.5

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    BACKGROUND: Food-dependent exercise-induced anaphylaxis (FDEIA) is characterized by anaphylactic symptoms after eating certain foods, followed by exercise. As we examine more patients who have pollinosis, we have more opportunities to see allergic disease such as FDEIA, OAS, and so on. METHODS: We performed a retrospective analysis of six cases, diagnosed FDEIA for this three years. RESULTS: Of six cases, the ages are 8 to 47 years old, and the trigger allergens were wheat, shrimp, and grapefruit. The trigger exercises were running, volleyball, as well as taking a bath. In four cases, the patients had history of allergic disease such as atopic dermatitis, allergic rhinitis, and so on. In two cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for omega5-gliadin (a major wheat allergen) in a RAST were positive. CONCLUSION: Of six cases diagnosed FDEIA, the trigger allergens were wheat, shrimp, and grapefruit. In cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for omega5-gliadin in a RAST were positive. After the food allergen has been identified, we advised strict restrictions on ingestion of trigger allergens in the case of shrimp and grapefruit, and on any exercise after eating foods containing wheat flour in the case of wheat.

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  • 当科における歯性上顎洞炎症例の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実

    日本耳鼻咽喉科感染症研究会会誌   27 ( 1 )   49 - 52   2009.5

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  • 当院での成人睡眠時無呼吸症候群における手術治療の評価 Reviewed

    小川 晃弘, 牧野 琢丸, 松本 亮典, 宮武 智実, 公文 啓二, 正木 昭次, 福本 初, 岸本 朋之, 柴田 泰弘, 柳 文修

    兵庫県医師会医学雑誌   51 ( 2 )   113 - 118   2009.4

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MISC

  • 光免疫療法:頭頸部アルミノックス治療の現況 光免疫療法後における病理組織学的検討

    牧野 琢丸, 佐藤 康晴, 安藤 瑞生

    日本癌治療学会学術集会抄録集   62回   OWS1 - 5   2024.10

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  • 診断に苦慮した舌内神経鞘腫の1例

    深澤 茉祐, 牧野 琢丸, 手島 大雅, 直井 勇人, 藤本 将平, 安藤 瑞生

    口腔・咽頭科   37 ( 3 )   239 - 239   2024.8

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  • 頭頸部アルミノックス治療により喉頭温存が可能となった再発下咽頭癌症例

    手島 大雅, 牧野 琢丸, 深澤 茉祐, 直井 勇人, 藤本 将平, 安藤 瑞生

    口腔・咽頭科   37 ( 3 )   254 - 254   2024.8

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  • 上咽頭癌再発遺残に対するアルミノックス療法 多施設観察研究

    篠崎 剛, 樽谷 貴之, 岡本 伊作, 小村 豪, 牧野 琢丸, 遠藤 一平, 櫛橋 幸民, 大峡 慎一, 和佐野 浩一郎, 齊藤 祐毅, 望月 大極, 皆木 正人, 加藤 久幸, 竹本 剛, 佐野 大佑, 西谷 友樹雄, 坂下 信悟, 森 泰昌

    頭頸部癌   50 ( 2 )   189 - 189   2024.5

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  • 舌根部癌に対する頭頸部アルミノックス治療の検討

    牧野 琢丸, 松井 裕輔, 藤本 将平, 秋定 直樹, 直井 勇人, 平木 隆夫, 安藤 瑞生

    頭頸部癌   50 ( 2 )   188 - 188   2024.5

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  • 3Dバイオプリンターを用いたCAFとがん細胞の位置関係についての検討

    直井 勇人, 長崎 譲慈, 秋定 直樹, 藤本 将平, 牧野 琢丸, 冨樫 庸介, 安藤 瑞生

    頭頸部癌   50 ( 2 )   159 - 159   2024.5

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  • 上顎再建 遊離腓骨移植による上顎再建

    松本 洋, 太田 智之, 加藤 基, 武田 斉子, 牧野 琢丸, 安藤 瑞生

    頭頸部癌   50 ( 2 )   105 - 105   2024.5

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  • 上顎再建 遊離腓骨移植による上顎再建

    松本 洋, 太田 智之, 加藤 基, 武田 斉子, 牧野 琢丸, 安藤 瑞生

    頭頸部癌   50 ( 2 )   105 - 105   2024.5

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Presentations

  • Histopathological study after Near-infrared photoimmunotherapy Invited

    Takuma Makino

    The 62nd Annual Meeting of the Japan Society of Clinical Oncology  2024.10.24 

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    Presentation type:Symposium, workshop panel (public)  

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  • 舌根部癌に対する頭頸部アルミノックス治療の検討

    牧野 琢丸, 松井 裕輔, 藤本 将平, 秋定 直樹, 直井 勇人, 平木 隆夫, 安藤 瑞生

    頭頸部癌  2024.5  (一社)日本頭頸部癌学会

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    Event date: 2024.5

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  • 頭頸部アルミノックス治療(光免疫療法) Invited

    加藤 久幸, 伊藤 通子, 牧野 琢丸

    第36回日本喉頭科学会学術講演会  2024.3.8 

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    Event date: 2024.3.7 - 2024.3.8

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 口腔・咽頭癌における頭頸部アルミノックス治療(光免疫療法)の実際

    牧野 琢丸

    口腔・咽頭科  2023.8  日本口腔・咽頭科学会

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    Event date: 2023.8

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  • 頭頸部がんに対する光免疫療法(頭頸部アルミノックス治療) Invited

    牧野琢丸

    第34回西日本レーザー医学会西日本大会  2023.7.29 

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    Event date: 2023.7.29

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  • Computed tomography for the diagnosis of follicular thyroid neoplasm

    Takuma Makino

    The 2nd Congress of Asia-Pacific Society of Thyroid Surgery  2017.11.2 

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    Event date: 2017.11.1 - 2017.11.3

    Language:English   Presentation type:Poster presentation  

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  • 診断に苦慮した舌内神経鞘腫の1例

    深澤 茉祐, 牧野 琢丸, 手島 大雅, 直井 勇人, 藤本 将平, 安藤 瑞生

    口腔・咽頭科  2024.8  日本口腔・咽頭科学会

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    Event date: 2024.8

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  • 頭頸部アルミノックス治療により喉頭温存が可能となった再発下咽頭癌症例

    手島 大雅, 牧野 琢丸, 深澤 茉祐, 直井 勇人, 藤本 将平, 安藤 瑞生

    口腔・咽頭科  2024.8  日本口腔・咽頭科学会

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    Event date: 2024.8

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  • 上顎再建 遊離腓骨移植による上顎再建

    松本 洋, 太田 智之, 加藤 基, 武田 斉子, 牧野 琢丸, 安藤 瑞生

    頭頸部癌  2024.5  (一社)日本頭頸部癌学会

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    Event date: 2024.5

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  • 上咽頭癌再発遺残に対するアルミノックス療法 多施設観察研究

    篠崎 剛, 樽谷 貴之, 岡本 伊作, 小村 豪, 牧野 琢丸, 遠藤 一平, 櫛橋 幸民, 大峡 慎一, 和佐野 浩一郎, 齊藤 祐毅, 望月 大極, 皆木 正人, 加藤 久幸, 竹本 剛, 佐野 大佑, 西谷 友樹雄, 坂下 信悟, 森 泰昌

    頭頸部癌  2024.5  (一社)日本頭頸部癌学会

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    Event date: 2024.5

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  • 3Dバイオプリンターを用いたCAFとがん細胞の位置関係についての検討

    直井 勇人, 長崎 譲慈, 秋定 直樹, 藤本 将平, 牧野 琢丸, 冨樫 庸介, 安藤 瑞生

    頭頸部癌  2024.5  (一社)日本頭頸部癌学会

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    Event date: 2024.5

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  • 局所進行舌癌における対側リンパ節転移の出現規定因子に関する検討

    赤松 摩紀, 牧野 琢丸, 森田 慎也, 藤本 将平, 渡部 佳弘, 木股 敬裕, 安藤 瑞生, 今西 順久

    日本癌治療学会学術集会抄録集  2023.10  (一社)日本癌治療学会

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    Event date: 2023.10

    Language:English  

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  • 術前にオンコサイトーマと診断し摘出術を実施した耳下腺癌の2例

    森脇 悠利, 秋定 直樹, 藤本 将平, 牧野 琢丸, 安藤 瑞生

    口腔・咽頭科  2023.8  日本口腔・咽頭科学会

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    Event date: 2023.8

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  • 頭頸部がんにおける免疫チェックポイント阻害薬の効果と末梢血液分画の関係

    直井 勇人, 秋定 直樹, 藤本 将平, 牧野 琢丸, 安藤 瑞生

    頭頸部癌  2023.5  (一社)日本頭頸部癌学会

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    Event date: 2023.5

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  • 頭頸部癌の肺転移例に対するRFAの適応と有用性

    藤本 将平, 牧野 琢丸, 松井 裕輔, 平木 隆夫, 秋定 直樹, 安藤 瑞生

    頭頸部癌  2023.5  (一社)日本頭頸部癌学会

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    Event date: 2023.5

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  • 岡山大学病院頭頸部がんセンターにおける妊娠・出産への配慮の実状

    秋定 直樹, 牧野 琢丸, 安藤 瑞生

    日本がん・生殖医療学会誌  2023.2  (一社)日本がん・生殖医療学会

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    Event date: 2023.2

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  • 3Dビデオ搭載外視鏡システムORBEYEを用いて中咽頭腫瘍切除を行った1例

    田口 佳典, 大道 亮太郎, 佐藤 明日香, 藤澤 郁, 牧野 琢丸, 安藤 瑞生

    口腔・咽頭科  2022.8  日本口腔・咽頭科学会

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    Event date: 2022.8

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  • ニボルマブ投与後に高度な貧血・浮腫を来した症例

    浦口 健介, 秋定 直樹, 牧野 琢丸, 安藤 瑞生

    口腔・咽頭科  2022.8  日本口腔・咽頭科学会

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    Event date: 2022.8

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  • 思春期・若年の舌癌を迅速に診断し余裕を持って妊孕性温存療法を行うために

    秋定 直樹, 牧野 琢丸, 浦口 健介, 安藤 瑞生

    口腔・咽頭科  2022.8  日本口腔・咽頭科学会

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    Event date: 2022.8

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  • 嚥下困難を契機に診断された大動脈解離の一例

    佐藤 明日香, 藤澤 郁, 牧野 琢丸, 安藤 瑞生

    口腔・咽頭科  2022.8  日本口腔・咽頭科学会

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    Event date: 2022.8

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  • 下咽頭ESD後の変形予防にValsalva法が有効であった1例

    佐藤 大直, 濱田 健太, 安部 真, 牧野 琢丸, 藤澤 郁, 岡上 昇太郎, 河野 吉泰, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器内視鏡学会中国支部例会  2022.5  日本消化器内視鏡学会-中国支部

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    Event date: 2022.5

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  • 下顎骨区域切除または半側切除後の顎関節脱臼についての臨床的検討

    武田 斉子, 水川 展吉, 松本 洋, 牧野 琢丸, 安藤 瑞生, 木股 敬裕

    頭頸部癌  2022.5  (一社)日本頭頸部癌学会

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    Event date: 2022.5

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  • 頭頸部癌治療後いつから妊娠を試みるべきか

    秋定 直樹, 牧野 琢丸, 安藤 瑞生

    頭頸部癌  2022.5  (一社)日本頭頸部癌学会

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    Event date: 2022.5

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  • 耳下腺唾液腺導管癌術後再発に対して頭頸部イルミノックス治療を行った1例

    駿河 有莉, 牧野 琢丸, 直井 勇人, 秋定 直樹, 浦口 健介, 大道 亮太郎, 假谷 伸, 安藤 瑞生

    頭頸部癌  2022.5  (一社)日本頭頸部癌学会

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    Event date: 2022.5

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  • 5年の経過で増大した上咽頭plasma cell granulomaの一例

    駿河 有莉, 牧野 琢丸, 假谷 伸, 安藤 瑞生

    口腔・咽頭科  2021.8  日本口腔・咽頭科学会

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    Event date: 2021.8

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  • 15回目のセツキシマブ投与でinfusion reactionをきたした1例

    宮本 翔太郎, 牧野 琢丸, 牧原 靖一郎, 假谷 伸, 安藤 瑞生

    耳鼻咽喉科臨床 補冊  2021.6  耳鼻咽喉科臨床学会

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    Event date: 2021.6

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  • 下顎骨半側切除および区域切除における咬合管理と術後機能についての臨床的検討

    武田 斉子, 水川 展吉, 田村 庄平, 宮崎 文伸, 野田 洋平, 牧野 琢丸, 丸中 秀格, 安藤 瑞生, 松本 洋, 木股 敬裕

    頭頸部癌  2021.5  (一社)日本頭頸部癌学会

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    Event date: 2021.5

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  • 当科で加療を行った頭頸部原発肉腫についての検討

    梶原 壮平, 牧野 琢丸, 浦口 健介, 假谷 伸, 安藤 瑞生

    頭頸部癌  2021.5  (一社)日本頭頸部癌学会

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    Event date: 2021.5

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  • 鼻副鼻腔異所性髄膜腫の1例

    藤本 将平, 檜垣 貴哉, 牧野 琢丸, 西崎 和則

    日本耳鼻咽喉科学会会報  2020.9  (一社)日本耳鼻咽喉科頭頸部外科学会

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    Event date: 2020.9

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  • 外科的切除を必要とした下顎骨血管奇形の2例

    森田 慎也, 野田 洋平, 牧野 琢丸, 假谷 伸

    口腔・咽頭科  2020.8  日本口腔・咽頭科学会

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    Event date: 2020.8

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  • 舌亜全摘出術施行症例における頸部郭清範囲の検討

    赤松 摩紀, 牧野 琢丸, 森田 慎也, 藤本 将平, 野田 洋平, 假谷 伸, 西崎 和則

    頭頸部癌  2020.7  (一社)日本頭頸部癌学会

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    Event date: 2020.7

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  • 咽頭ESD後の下咽頭変形と誤嚥性肺炎についての検討

    馬場 雄己, 安部 真, 河原 祥朗, 岡本 雄貴, 大林 由佳, 榮 浩行, 濱田 健太, 神崎 洋光, 岩室 雅也, 川野 誠司, 津村 宗近, 牧野 琢丸, 野田 洋平, 丸中 秀格, 岡田 裕之

    耳鼻咽喉科展望  2019.10  耳鼻咽喉科展望会

  • 上咽頭明細胞癌の1例

    浜崎 龍平, 牧野 琢丸, 藤本 将平, 津村 宗近, 野田 洋平, 假谷 伸, 西崎 和則

    口腔・咽頭科  2019.8  日本口腔・咽頭科学会

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    Event date: 2019.8

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  • セツキシマブ投与中に腸管気腫を生じた2例

    野田 洋平, 假谷 伸, 黒田 一範, 津村 宗近, 牧野 琢丸, 丸中 秀格, 西崎 和則

    耳鼻咽喉科臨床 補冊  2019.6  耳鼻咽喉科臨床学会

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    Event date: 2019.6

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  • 岡山大学病院頭頸部がんセンターにおける多職種連携について 言語聴覚士の立場から

    古西 隆之, 牧野 琢丸, 藤本 将平, 武田 斉子, 長本 幸子, 久保 和子, 假谷 伸, 木股 敬裕, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 両側上顎切除後の無歯顎症例に対し、顎骨再建後のインプラントで咬合機能回復が行われた2症例

    水川 展吉, 松本 洋, 西川 悟郎, 津村 宗近, 上田 明広, 武田 斉子, 小盛 麻衣, 宮崎 文伸, 野田 洋平, 丸中 秀格, 牧野 琢丸, 小野田 友男, 田村 庄平, 木股 敬裕

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 上顎に発生したエナメル上皮線維肉腫の1例

    野田 洋平, 假谷 伸, 津村 宗近, 牧野 琢丸, 橘 智靖, 丸中 秀格, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 岡山大学病院頭頸部がんセンターにおける多職種連携について 医科の立場から

    藤本 将平, 牧野 琢丸, 野田 洋平, 津村 宗近, 丸中 秀格, 松本 洋, 武田 斉子, 長本 幸子, 久保 和子, 古西 隆之, 假谷 伸, 木股 敬裕, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 岡山大学病院頭頸部がんセンターにおける多職種連携について 歯科の立場から

    武田 斉子, 牧野 琢丸, 水川 展吉, 宮崎 文伸, 藤本 将平, 長本 幸子, 久保 和子, 古西 隆之, 假谷 伸, 木股 敬裕, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 岡山大学病院頭頸部がんセンターにおける多職種連携について 看護師の立場から

    長本 幸子, 牧野 琢丸, 梶清 友美, 藤本 将平, 武田 斉子, 久保 和子, 古西 隆之, 假谷 伸, 木股 敬裕, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 岡山大学病院頭頸部がんセンターにおける多職種連携について 薬剤師の立場から

    久保 和子, 牧野 琢丸, 千堂 年昭, 藤本 将平, 武田 斉子, 長本 幸子, 古西 隆之, 假谷 伸, 木股 敬裕, 西崎 和則

    頭頸部癌  2019.5  (一社)日本頭頸部癌学会

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    Event date: 2019.5

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  • 咽頭ESD後の下咽頭の変形と誤嚥性肺炎の発症に関する検討

    安部 真, 河原 祥朗, 岡本 雄貴, 大林 由佳, 馬場 雄己, 榮 浩行, 後藤田 達洋, 神崎 洋光, 岩室 雅也, 川野 誠司, 津村 宗近, 牧野 琢丸, 野田 洋平, 丸中 秀格, 岡田 裕之

    耳鼻咽喉科展望  2019.2  耳鼻咽喉科展望会

  • 耳下腺分泌癌の1経験例

    藤本 将平, 牧野 琢丸, 津村 宗近, 野田 洋平, 丸中 秀格, 假谷 伸, 西崎 和則

    口腔・咽頭科  2018.8  日本口腔・咽頭科学会

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    Event date: 2018.8

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  • 下咽頭癌再建手術後の遊離空腸腸間膜リンパ節に再発をきたした2例

    津村 宗近, 野田 洋平, 牧野 琢丸, 藤本 将平, 假谷 伸, 西崎 和則

    口腔・咽頭科  2018.8  日本口腔・咽頭科学会

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    Event date: 2018.8

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  • 気管憩室に対し手術加療を行った1例

    津村 宗近, 牧野 琢丸, 野田 洋平, 丸中 秀格, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2018.6  耳鼻咽喉科臨床学会

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    Event date: 2018.6

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  • CTにて石灰化陰影を呈した線維素性唾液管炎の3例

    直井 勇人, 橘 智靖, 春名 威範, 牧野 琢丸, 松山 祐子, 小松原 靖聡

    耳鼻咽喉科臨床 補冊  2018.6  耳鼻咽喉科臨床学会

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    Event date: 2018.6

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  • 耳下腺癌肉腫に対して術後BRTを施行した1例

    牧野 琢丸, 橘 智靖, 小松原 靖聡, 松山 祐子, 西崎 和則

    頭頸部癌  2018.5  (一社)日本頭頸部癌学会

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  • 当科におけるNivolumabの使用経験

    野田 洋平, 丸中 秀格, 津村 宗近, 牧野 琢丸, 久保 和子, 假谷 伸, 西崎 和則

    頭頸部癌  2018.5  (一社)日本頭頸部癌学会

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  • 喉頭癌治療後に発症した水痘帯状疱疹ウイルスによる反回神経麻痺の2例

    小松原 靖聡, 橘 智靖, 牧野 琢丸, 松山 祐子, 直井 勇人

    日本耳鼻咽喉科学会会報  2018.4  (一社)日本耳鼻咽喉科学会

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    Event date: 2018.4

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  • 甲状腺悪性リンパ腫の検討

    橘 智靖, 牧野 琢丸, 小松原 靖聡, 折田 頼尚, 西崎 和則

    日本内分泌・甲状腺外科学会雑誌  2017.10  日本内分泌外科学会・日本甲状腺外科学会

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    Event date: 2017.10

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  • 耳下腺リンパ腺腫の2例

    牧野 琢丸, 橘 智靖

    口腔・咽頭科  2017.8  日本口腔・咽頭科学会

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    Event date: 2017.8

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  • 喉頭乳頭腫におけるhuman papilloma virus(HPV)

    折田 頼尚, 橘 智靖, 丸中 秀格, 牧原 靖一郎, 山下 安彦, 三木 健太郎, 牧野 琢丸, 赤木 祐介, 秋定 直樹, 西崎 和則

    頭頸部癌  2017.5  (一社)日本頭頸部癌学会

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  • 舌癌におけるp16発現

    三木 健太郎, 橘 智靖, 丸中 秀格, 牧野 琢丸, 赤木 祐介, 秋定 直樹, 小野田 友男, 西崎 和則

    頭頸部癌  2017.5  (一社)日本頭頸部癌学会

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  • 舌癌におけるPD-L1の発現解析

    秋定 直樹, 折田 頼尚, 橘 智靖, 丸中 秀格, 三木 健太郎, 牧野 琢丸, 赤木 祐介, 石原 久司, 小野田 友男, 西崎 和則

    頭頸部癌  2017.5  (一社)日本頭頸部癌学会

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  • 声門癌におけるMACC1と再発・転移の関連について

    牧野 琢丸, 折田 頼尚, 橘 智靖, 丸中 秀格, 牧原 靖一郎, 三木 健太郎, 赤木 祐介, 秋定 直樹, 西崎 和則

    頭頸部癌  2017.5  (一社)日本頭頸部癌学会

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  • 頸部嚢胞性疾患に対する硬化療法の臨床的検討

    橘 智靖, 牧野 琢丸, 小松原 靖聡, 折田 頼尚, 西崎 和則

    日本耳鼻咽喉科学会会報  2017.4  (一社)日本耳鼻咽喉科学会

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  • 気管憩室を併存した甲状腺乳頭癌例

    橘 智靖, 牧野 琢丸, 小松原 靖聡, 折田 頼尚

    日本内分泌・甲状腺外科学会雑誌  2016.9  日本内分泌外科学会・日本甲状腺外科学会

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  • 造影CT画像による濾胞性腫瘍の評価

    折田 頼尚, 牧野 琢丸, 橘 智靖, 丸中 秀格, 三木 健太郎, 赤木 祐介, 小松原 靖聡, 秋定 直樹, 西崎 和則

    日本内分泌・甲状腺外科学会雑誌  2016.9  日本内分泌外科学会・日本甲状腺外科学会

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  • 耳鼻咽喉科を受診した異物症例の検討

    橘 智靖, 牧野 琢丸, 松山 祐子, 清水 藍子, 小松原 靖聡

    姫路赤十字病院誌  2016.7  姫路赤十字病院図書学術委員会

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  • CTにて石灰化陰影を呈した線維素性唾液管炎の1例

    清水 藍子, 橘 智靖, 牧野 琢丸, 松山 祐子, 小松原 靖聡

    耳鼻咽喉科臨床 補冊  2016.6  耳鼻咽喉科臨床学会

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  • 舌癌発生過程におけるマクロファージの浸潤

    折田 頼尚, 三木 健太郎, 橘 智靖, 丸中 秀格, 牧野 琢丸, 秋定 直樹, 西崎 和則

    頭頸部癌  2016.5  (一社)日本頭頸部癌学会

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  • 舌癌におけるp16発現

    三木 健太郎, 折田 頼尚, 橘 智靖, 丸中 秀格, 牧野 琢丸, 牧原 靖一郎, 平井 美紗都, 秋定 直樹, 小野田 友男, 西崎 和則

    頭頸部癌  2016.5  (一社)日本頭頸部癌学会

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  • 頭頸部領域のVerrucous CarcinomaにおけるHuman papillomavirusの関与について

    牧野 琢丸, 折田 頼尚, 橘 智靖, 丸中 秀格, 牧原 靖一郎, 平井 美紗都, 三木 健太郎, 西崎 和則

    日本耳鼻咽喉科学会会報  2016.4  (一社)日本耳鼻咽喉科学会

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  • Verrucous carcinomaとHPV感染の関連性について

    松元 佳帆, 祇園 由佳, 牧野 琢丸, 折田 頼尚, 吉野 正, 佐藤 康晴

    日本病理学会会誌  2016.4  (一社)日本病理学会

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  • 術前診断が困難であったCarcinoma showing thymus-like differentiation(CASTLE)の1例

    橘 智靖, 折田 頼尚, 牧野 琢丸

    日本内分泌・甲状腺外科学会雑誌  2015.9  日本内分泌外科学会・日本甲状腺外科学会

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  • 成人に発生した副鼻腔ユーイング肉腫の1例

    津村 宗近, 小野田 友男, 内藤 智之, 藤野 泰志, 牧野 琢丸, 野田 洋平, 西崎 和則

    耳鼻咽喉科臨床 補冊  2015.6  耳鼻咽喉科臨床学会

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  • 頸椎転移を伴う上咽頭癌に対して、反復した化学療法を行い、その後放射線化学療法が奏功した1例

    内藤 智之, 小野田 友男, 西崎 和則, 野田 洋平, 津村 宗近, 牧野 琢丸, 藤野 泰志

    耳鼻咽喉科臨床 補冊  2015.6  耳鼻咽喉科臨床学会

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  • 人工呼吸器症例の誤嚥防止手術の術式選択

    藤野 泰志, 小野田 友男, 野田 洋平, 西崎 和則, 牧野 琢丸, 津村 宗近, 内藤 智之

    耳鼻咽喉科臨床 補冊  2015.6  耳鼻咽喉科臨床学会

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  • 岡山大学病院頭頸部がんセンターにおける医科歯科連携手術の実態

    水川 展吉, 木股 敬裕, 小野田 友男, 武田 斉子, 福島 麻衣, 吉岡 洋佑, 牧野 琢丸, 野田 洋平, 竹内 哲男, 田村 庄平, 松本 洋

    頭頸部癌  2015.5  (一社)日本頭頸部癌学会

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  • エホバの証人に希釈式自己血輸血で対応し手術した1例

    藤野 泰志, 小野田 友男, 野田 洋平, 津村 宗近, 牧野 琢丸, 西崎 和則

    頭頸部癌  2015.5  (一社)日本頭頸部癌学会

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  • 岡山県内胃瘻造設術施行施設へのアンケートからみる嚥下機能評価における耳鼻咽喉科医の役割

    西崎 和則, 春名 威範, 牧野 琢丸, 三木 健太郎, 野田 洋平, 檜垣 貴哉, 菅谷 明子, 小野田 友男

    日本耳鼻咽喉科学会会報  2015.4  (一社)日本耳鼻咽喉科学会

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  • 骨転移と診断された骨髄過形成例

    小野田 友男, 牧野 琢丸, 浦口 健介, 藤本 将平, 西崎 和則

    口腔・咽頭科  2014.8  日本口腔・咽頭科学会

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  • 当科における耳下腺悪性腫瘍症例の検討

    藤本 将平, 小野田 友男, 浦口 健介, 牧野 琢丸, 假谷 伸, 西崎 和則

    口腔・咽頭科  2014.8  日本口腔・咽頭科学会

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  • 下肢麻痺により転移性多形腺腫が発見された1例

    浦口 健介, 藤本 将平, 牧野 琢丸, 小野田 友男, 假谷 伸, 西崎 和則

    口腔・咽頭科  2014.8  日本口腔・咽頭科学会

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  • 頬部小唾液腺多形腺腫の1例

    牧野 琢丸, 小野田 友男, 浦口 健介, 藤本 将平, 假谷 伸, 西崎 和則

    口腔・咽頭科  2014.8  日本口腔・咽頭科学会

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  • 下顎歯肉癌にて金属プレート再建施行後に舌下神経麻痺を生じた2症例

    津村 宗近, 牧野 琢丸, 野田 洋平, 小野田 友男, 西崎 和則

    耳鼻咽喉科臨床 補冊  2014.6  耳鼻咽喉科臨床学会

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  • Maxillary Swing Approachにて手術を行った上顎軟骨肉腫の1例

    藤本 将平, 小野田 友男, 野田 洋平, 牧野 琢丸, 津村 宗近, 西崎 和則

    耳鼻咽喉科臨床 補冊  2014.6  耳鼻咽喉科臨床学会

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  • PET陽性で再発を疑われた上顎異物肉芽腫の1例

    小野田 友男, 牧野 琢丸, 津村 宗近, 野田 洋平, 藤本 将平, 西崎 和則

    耳鼻咽喉科臨床 補冊  2014.6  耳鼻咽喉科臨床学会

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  • ステノン管原発と考えられた扁平上皮癌の1例

    野田 洋平, 小野田 友男, 津村 宗近, 牧野 琢丸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2014.6  耳鼻咽喉科臨床学会

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  • 放射線治療後の頭頸部再建手術

    牧野 琢丸, 小野田 友男, 津村 宗近, 野田 洋平, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2014.6  耳鼻咽喉科臨床学会

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  • 当科における下顎歯肉癌の臨床的検討

    野田 洋平, 小野田 友男, 折田 頼尚, 牧野 琢丸, 津村 宗近, 西崎 和則

    頭頸部癌  2014.5  (一社)日本頭頸部癌学会

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  • 当科における上顎癌の治療の検討

    小野田 友男, 野田 洋平, 牧野 琢丸, 折田 頼尚, 西崎 和則

    頭頸部癌  2014.5  (一社)日本頭頸部癌学会

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  • 当科における上歯肉癌の検討

    牧野 琢丸, 小野田 友男, 津村 宗近, 野田 洋平, 折田 頼尚, 西崎 和則

    頭頸部癌  2014.5  (一社)日本頭頸部癌学会

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  • 岡山大学病院における鼻副鼻腔内視鏡手術の新しい手術分類の活用

    津村 宗近, 岡野 光博, 春名 威範, 仮谷 伸, 野田 洋平, 牧野 琢丸, 檜垣 貴哉, 野山 和廉, 牧原 靖一郎, 西崎 和則

    日本鼻科学会会誌  2013.9  (一社)日本鼻科学会

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  • 耳下腺乳腺類似分泌癌の1例

    牧野 琢丸, 小野田 友男, 浦口 健介, 清水 藍子, 藤本 将平, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科  2013.8  日本口腔・咽頭科学会

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  • メトトレキセート内服患者の舌癌治療経験

    藤本 将平, 小野田 友男, 浦口 健介, 牧野 琢丸, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科  2013.8  日本口腔・咽頭科学会

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  • 耳鳴を伴う上咽頭血管腫の一症例

    清水 藍子, 小野田 友男, 浦口 健介, 藤本 将平, 牧野 琢丸, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科  2013.8  日本口腔・咽頭科学会

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  • 上咽頭癌の初発症状別検討

    石原 久司, 宮武 智実, 牧野 琢丸, 牧原 靖一郎, 小野田 友男, 西崎 和則

    口腔・咽頭科  2013.8  日本口腔・咽頭科学会

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  • 健側顔面に皮膚転移をきたした唾液腺導管癌の1例

    浦口 健介, 小野田 友男, 藤本 将平, 牧野 琢丸, 江口 元治, 假谷 伸, 西崎 和則

    口腔・咽頭科  2013.8  日本口腔・咽頭科学会

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  • プロボックスボイスプロテーゼ留置症例の唾液漏出への対応の検討

    津村 宗近, 小野田 友男, 小山 貴久, 福本 晶, 山川 千鶴, 牧野 琢丸, 春名 威範, 江口 元治, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • スギ特異的免疫療法著効例の臨床的特徴 同一患者複数年による検討

    小山 貴久, 岡野 光博, 春名 威範, 山川 千鶴, 福本 晶, 津村 宗近, 牧野 琢丸, 野田 洋平, 小野田 友男, 西崎 和則

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • 肝硬変を合併した頭頸部癌症例の検討

    牧野 琢丸, 小野田 友男, 小山 貴久, 福本 晶, 山川 千鶴, 津村 宗近, 野田 洋平, 江口 元治, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • 当院における心因性難聴に対しての臨床的検討

    黒田 一彬, 小川 晃弘, 宮原 聡子, 西川 奈見, 小野田 友男, 牧野 琢丸, 春名 威範

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • 開口障害に対し外科的治療を行った頸部リンパ管腫の1例

    山川 千鶴, 小野田 友男, 福本 晶, 牧野 琢丸, 江口 元治, 西崎 和則

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • 縦隔気管孔形成術5症例の検討

    野田 洋平, 小野田 友男, 江口 元治, 牧野 琢丸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2013.7  耳鼻咽喉科臨床学会

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  • 咽頭の放射線性壊死に対して手術療法を行った2症例

    江口 元治, 小野田 友男, 牧野 琢丸, 木股 敬裕, 松本 洋

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • 舌癌症例の検討

    牧野 琢丸, 小野田 友男, 河野 達也, 小山 貴久, 津村 宗近, 野田 洋平, 江口 元治, 西崎 和則

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • トラスツズマブを投与した唾液腺導管癌2症例経験

    小山 貴久, 小野田 友男, 津村 宗近, 牧野 琢丸, 野田 洋平, 江口 元治, 西崎 和則

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • 当科におけるルビエール転移症例の検討

    小野田 友男, 牧野 琢丸, 小山 貴久, 野田 洋平, 江口 元治, 西崎 和則

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • 頭頸部癌に対する放射線化学療法後の甲状腺機能低下症の検討

    野田 洋平, 小野田 友男, 江口 元治, 牧野 琢丸, 津村 宗近, 小山 貴久, 西崎 和則

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • 下咽頭癌術後にたこつぼ型心筋症を発症した1例

    津村 宗近, 小野田 友男, 小山 貴久, 牧野 琢丸, 野田 洋平, 江口 元治, 西崎 和則

    頭頸部癌  2013.5  (一社)日本頭頸部癌学会

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  • 妊娠中に判明した上咽頭癌の1例

    牧野 琢丸, 小野田 友男, 春名 威範, 江口 元治, 西崎 和則

    日本耳鼻咽喉科学会会報  2013.4  (一社)日本耳鼻咽喉科学会

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  • 前頭洞結石の1例

    小川 晃弘, 黒田 一彬, 宮原 聡子, 西川 奈見, 春名 威範, 牧野 琢丸, 大崎 勝一郎, 牧 孝

    日本耳鼻咽喉科学会会報  2013.4  (一社)日本耳鼻咽喉科学会

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  • 頬部脂肪体弁を用いた口腔癌切除後再建症例の検討

    小野田 友男, 牧野 琢丸, 小山 貴久, 假谷 伸, 西崎 和則

    口腔・咽頭科  2012.8  日本口腔・咽頭科学会

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  • 当科における上咽頭癌症例の検討

    牧野 琢丸, 小野田 友男, 小山 貴久, 假谷 伸, 西崎 和則

    口腔・咽頭科  2012.8  日本口腔・咽頭科学会

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  • 岡山大学における中咽頭癌症例の治療成績

    小山 貴久, 小野田 友男, 牧野 琢丸, 西崎 和則

    口腔・咽頭科  2012.8  日本口腔・咽頭科学会

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  • 表在癌に対する化学療法の効果の検討

    小野田 友男, 江口 元治, 牧野 琢丸

    耳鼻咽喉科臨床 補冊  2012.7  耳鼻咽喉科臨床学会

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  • Charcot-Marie-Tooth病に感音難聴を合併し、ステロイド依存性難聴様の経過を示した小児の1例

    福島 邦博, 前田 幸英, 大道 亮太郎, 牧野 琢丸, 片岡 祐子, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2012.7  耳鼻咽喉科臨床学会

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  • 放射線治療後に発生した喉頭腺癌の1例

    牧野 琢丸, 小野田 友男, 宮武 智実, 江口 元治, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2012.7  耳鼻咽喉科臨床学会

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  • 化学放射線療法におけるCDGP投与量の検討

    宮武 智実, 小野田 友男, 石原 久司, 牧野 琢丸, 江口 元治, 假谷 伸, 折田 頼尚, 福島 邦博, 岡野 光博, 西崎 和則

    耳鼻咽喉科臨床 補冊  2012.7  耳鼻咽喉科臨床学会

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  • ハーモニックスカルペル、リガシュアを使用した上顎全摘

    小野田 友男, 江口 元治, 牧野 琢丸, 石原 久司, 折田 頼尚, 花川 浩之, 西崎 和則

    頭頸部癌  2012.5  (一社)日本頭頸部癌学会

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  • 頭頸部癌に対する化学放射線療法後の救済手術

    江口 元治, 小野田 友男, 牧野 琢丸, 石原 久司, 折田 頼尚, 花川 浩之, 西崎 和則

    頭頸部癌  2012.5  (一社)日本頭頸部癌学会

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  • 頭頸部癌に対するサイバーナイフ治療の検討

    牧野 琢丸, 小野田 友男, 江口 元治, 姫井 健吾, 春名 威範, 折田 頼尚, 西崎 和則

    頭頸部癌  2012.5  (一社)日本頭頸部癌学会

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  • 内眼角部ボーエン病から副鼻腔癌へ進展した1例

    宮武 智実, 假谷 伸, 岡野 光博, 平井 悠, 小野田 友男, 牧野 琢丸, 西崎 和則

    日本鼻科学会会誌  2011.11  (一社)日本鼻科学会

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  • 半導体レーザー治療が有効であった口腔咽頭静脈奇形の1例

    大道 亮太郎, 小野田 友男, 和田 昂, 平井 悠, 石原 久司, 牧野 琢丸, 假谷 伸, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

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  • 下顎骨二次性エナメル上皮癌の1例

    石原 久司, 小野田 友男, 假谷 伸, 牧野 琢丸, 平井 悠, 和田 昂, 大道 亮太郎, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

  • 下顎骨肉腫の1例

    和田 昂, 小野田 友男, 假谷 伸, 牧野 琢丸, 石原 久司, 平井 悠, 大道 亮太郎, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

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  • 当科における上歯肉・硬口蓋扁平上皮癌の臨床的検討

    小野田 友男, 牧野 琢丸, 石原 久司, 平井 悠, 大道 亮太郎, 和田 昂, 假谷 伸, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

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  • 耳下腺筋上皮癌の1例

    牧野 琢丸, 小野田 友男, 大道 亮太郎, 和田 昂, 石原 久司, 平井 悠, 假谷 伸, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

  • トラスツズマブにより腫瘍縮小効果を得た唾液腺導管癌の1例

    平井 悠, 小野田 友男, 大道 亮太郎, 和田 昂, 石原 久司, 牧野 琢丸, 假谷 伸, 西崎 和則

    口腔・咽頭科  2011.8  日本口腔・咽頭科学会

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  • 当院におけるTEシャント発声の臨床的検討

    平井 悠, 小野田 友男, 石原 久司, 河野 達也, 春名 威範, 牧野 琢丸, 西崎 和則

    耳鼻咽喉科臨床 補冊  2011.6  耳鼻咽喉科臨床学会

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  • First Bite Syndromeに対するプレバガリンの有効性についての研究

    小野田 友男, 牧野 琢丸, 石原 久司, 平井 悠, 江口 元治, 西崎 和則

    耳鼻咽喉科臨床 補冊  2011.6  耳鼻咽喉科臨床学会

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  • 岡山大学病院におけるT1、T2下咽頭癌の検討と治療戦略

    石原 久司, 小野田 友男, 牧野 琢丸, 平井 悠, 河野 達也, 春名 威範, 江口 元治, 西崎 和則

    耳鼻咽喉科臨床 補冊  2011.6  耳鼻咽喉科臨床学会

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  • 岡山大学病院におけるT3、T4下咽頭癌症例の検討と治療戦略

    牧野 琢丸, 小野田 友男, 石原 久司, 平井 悠, 河野 達也, 春名 威範, 江口 元治, 西崎 和則

    耳鼻咽喉科臨床 補冊  2011.6  耳鼻咽喉科臨床学会

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  • 頸部郭清後疼痛に対するプレガバリンの有効性についての研究

    小野田 友男, 江口 元治, 折田 頼尚, 牧野 琢丸, 河野 達也

    頭頸部癌  2011.5  (一社)日本頭頸部癌学会

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  • 下咽頭・内視鏡下手術における神経損傷危険部位の研究

    小野田 友男, 江口 元治, 河野 達也, 牧野 琢丸, 石原 久司, 平井 悠, 西崎 和則

    日本耳鼻咽喉科学会会報  2011.4  (一社)日本耳鼻咽喉科学会

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  • 当科における舌癌症例の臨床検討

    河野 達也, 小野田 友男, 牧野 琢丸, 阿部 郁, 假谷 伸, 西崎 和則

    口腔・咽頭科  2010.8  日本口腔・咽頭科学会

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  • 当科における耳下腺腫瘍症例の検討

    牧野 琢丸, 小野田 友男, 河野 達也, 阿部 郁, 假谷 伸, 西崎 和則

    口腔・咽頭科  2010.8  日本口腔・咽頭科学会

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  • 当院におけるアスピリン喘息症例の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実

    日本鼻科学会会誌  2009.8  (一社)日本鼻科学会

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  • 耳鼻咽喉科で経験した食物依存性運動誘発アナフィラキシー(FDEIA:Food-Dependent Exercise-Induced Anaphylaxis)症例の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 岡野 光博

    アレルギー  2009.5  (一社)日本アレルギー学会

  • 当院での成人睡眠時無呼吸症候群における手術治療の評価

    小川 晃弘, 牧野 琢丸, 松本 亮典, 宮武 智実, 公文 啓二, 正木 昭次, 福本 初, 岸本 朋之, 柴田 泰弘, 柳 文修

    兵庫県医師会医学雑誌  2009.4  (一社)兵庫県医師会

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  • 睡眠時無呼吸症候群治療中にFDEIA発作を反復した1症例

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実, 山本 哲也, 野口 敏生, 岡野 光博

    アレルギーの臨床  2009.2  (株)北隆館

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  • 当科で経験した食物依存性運動誘発アナフィラキシー(FDEIA:Food-dependent exercise-induced anaphylaxis)症例の検討

    松本 亮典, 小川 晃弘, 牧野 琢丸, 宮武 智実, 山本 哲也, 岡野 光博, 谷本 一憲

    耳鼻咽喉科免疫アレルギー  2008.9  日本耳鼻咽喉科免疫アレルギー学会

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  • 見落としがちな上気道急性感染症 急性喉頭蓋炎例での喉頭所見の検討を中心に

    牧野 琢丸, 宮武 智実, 松本 亮典, 小川 晃弘, 谷本 一憲, 松岡 寿子

    姫路聖マリア病院誌  2008.8  (医財)姫路聖マリア会

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  • 【副鼻腔疾患の治療 保存的か観血的か・その決断の時】歯性上顎洞炎

    小川 晃弘, 牧野 琢丸, 岡野 光博

    ENTONI  2008.7  (株)全日本病院出版会

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  • 緊急気道確保を必要とした頸部膿瘍症例の検討

    松本 亮典, 小川 晃弘, 谷本 一憲, 牧野 琢丸, 中 希久子

    日本耳鼻咽喉科感染症研究会会誌  2008.5  日本耳鼻咽喉科感染症研究会

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  • スギ花粉症患者に対するオロパタジン塩酸塩使用実態下における患者満足度調査

    小川 晃弘, 松本 亮典, 牧野 琢丸, 宮武 智実, 岡野 光博, 黒坂 文武

    アレルギー  2008.4  (一社)日本アレルギー学会

  • 骨形成性多発骨転移はじめ全身転移を来した頬粘膜下原発腺癌の1例

    牧野 琢丸, 小川 晃弘, 谷本 一憲, 松本 亮典, 冨永 進, 市村 浩一

    日本耳鼻咽喉科学会会報  2008.4  (一社)日本耳鼻咽喉科学会

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  • 睡眠時無呼吸症候群(SAS)を呈し、術中急性呼吸不全から縦隔炎をきたしたT細胞リンパ腫の1例

    小川 晃弘, 中 希久子, 松本 亮典, 谷本 一憲, 牧野 琢丸, 高原 寛, 公文 啓二, 長谷川 英夫

    日本気管食道科学会会報  2007.10  (NPO)日本気管食道科学会

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Research Projects

  • 頭頸部がんに対するがん光免疫療法における治療抵抗性因子の探索

    Grant number:23K15888  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  若手研究

    牧野 琢丸

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • がん遺伝子シグナル経路の網羅的解析による頭頸部がんの病態解析と新規治療法の開発

    Grant number:19K18731  2019.04 - 2023.03

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    牧野 琢丸

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    Grant amount:\3900000 ( Direct expense: \3000000 、 Indirect expense:\900000 )

    Metastasis-associated with colon cancer 1(以下MACC1)は、PI3K/AKTシグナル経路を介してさまざまな悪性腫瘍の病態に関与している。しかし、頭頸部癌とMACC1の関連については報告がない。
    本研究では、頭頸部癌におけるMACC1の発現を調べ、さらにPI3K/AKTシグナル経路がどのように病態に関与しているかを調べ、MACC1以外にも検出された因子があれば、臨床因子との関連を検討する。
    具体的には、ヒト頭頸部癌症例の手術・組織生検の際に切除した組織を用いてPI3K/AKTシグナル経路関連因子の網羅的検討を行う。採取した組織を用いて遺伝子アレイ解析を行う。アレイ解析では多くの因子に発現の変化がみられることが予想され、予後や治療効果などの臨床データとの関連性を調べることにより、それらの因子の臨床的意義を解析し、重要と思われる因子の絞り込みをおこなう。絞り込まれた因子に関して組織中の局在を免疫組織学的に検討する。臨床的に意義深い可能性のある因子に関して、ヒト培養癌細胞株を用いた検討を行う。これらの検討により、MACC1をはじめそれぞれの因子が臨床経過に悪影響をもたらす原因を分子レベルで明らかにする。さらに、頭頸部癌モデルマウスを用いて、ヒト腫瘍組織での検討を通じて絞り込まれたPI3K/AKTの関連因子について、免疫組織学的検討により確認し、PCR法により定量評価する。
    以上により、MACC1、PI3K/AKTシグナル経路に注目し、頭頸部癌に対する新規治療法やバイオマーカーの確立を目指す。

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Class subject in charge

  • Otolaryngology (2024academic year) Second semester  - 木3

  • Otolaryngology (2023academic year) Second semester  - 木3