Faculty Profiles - TAKIGAWA Masaharu

MISC - TAKIGAWA Masaharu

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結合組織成長因子(CCN2/CTGF)とアグリカンとの結合の生理的意義の解析

青山絵理子, 服部高子, 荒木大介, 星島光博, 滝川正春

日本骨代謝学会学術集会プログラム抄録集 25th 2007

軟骨細胞においてマトリックス金属プロテアーゼ-3(MMP3)は核移行し結合組織成長因子(CCN2/CTGF)の転写活性化因子として働く

江口傑徳, 久保田聡, 河田かずみ, 椋代義樹, 大河原敏博, 上原淳二, 伊原木聰一郎, 佐々木朗, 窪木拓男, 滝川正春, 滝川正春

生化学 2007

軟骨細胞にみられる低密度リポタンパク受容体関連タンパク1(LRP1)の局在と機能の解析

河田かずみ, 河田かずみ, 久保田聡, 江口傑徳, 青山絵里子, 川木晴美, 岡森彦, 皆木省吾, 滝川正春

日本軟骨代謝学会プログラム・抄録集 20th 2007

Plasma connective tissue growth factor is a potential marker of diastolic function and myocardial fibrosis in patients with chronic heart failure

Norimichi Koitabashi, Masashi Arai, Kazuo Niwano, Atai Watanabe, Hiroshi Tada, Takuji Toyama, Hitoshi Adachi, Shigeto Naito, Shigeru Oshima, Takashi Nishicla, Satoshi Kubota, Masaharu Takigawa, Masahiko Kurabayashi

CIRCULATION 114 ( 18 ) 372 - 372 2006.10

Purification and functional characterization of a protein that regulate ccn2 gene expression during chicken chondrocyte differentiation.

Y. Mukudai, S. Kubota, S. Kondo, T. Eguchi, H. Kawaki, M. Takigawa

JOURNAL OF BONE AND MINERAL RESEARCH 21 S149 - S149 2006.9

CCN ファミリータンパク質の内軟骨性骨化制御機構と骨・軟骨再生作用 Reviewed

久保田聡, 椋代義樹, 菊池剛, 大野充昭, 川木晴美, 柳田剛志, 西田崇, 田畑泰彦, 窪木拓男, 滝川正春

第24 回日本骨代謝学会シンポジウム硬組織再生研究の最前線（2006.7.7. 東京） 24th 2006

CCN2ノックアウトマウスを用いた内軟骨性骨化過程におけるCCNファミリーメンバーの役割の解析

川木晴美, 久保田聡, 鈴木晶子, PERBAL Bernard, 前田健康, LYONS Karen M, 滝川正春

日本骨代謝学会学術集会プログラム抄録集 24th 168 2006

ラット大腿骨骨欠損におけるCTGF/CCN2 の効果 Reviewed

菊池剛, 浅海浩二, 三谷茂, 尾崎敏文, 久保田聡, 河田かずみ, 滝川正春, 田畑泰彦

第24 回日本骨代謝学会学術集会（2006.7.7. 東京） 2006

The gene expressions of connective tissue growth factor and brain natriuretic peptide are coordinately regulated in cardiac myocytes

N Koitabashi, MAM Morita, S Hara, K Niwano, A Watanabe, M Kurabayashi, N Takashi, S Kubota, M Takigawa

JOURNAL OF CARDIAC FAILURE 11 ( 9 ) S316 - S316 2005.12

The balance of connective tissue growth factor and brain natriuretic peptide regulates myocardial fibrosis and stiffness

N Koitabashi, M Arai, M Morita, S Hara, K Niwano, A Watanabe, M Kurabayashi, T Nishida, S Kubota, M Takigawa

JOURNAL OF CARDIAC FAILURE 11 ( 9 ) S278 - S278 2005.12

Interplay of connective tissue growth factor and brain natriuretic peptide secreted by cardiac myocytes regulates collagen production in cardiac fibroblasts

N Koitabashi, M Arai, M Morita, S Hara, K Niwano, A Watanabe, M Kurabayashi, S Kubota, T Nishida, M Takigawa

CIRCULATION 112 ( 17 ) U153 - U153 2005.10

Disproportionate increase of plasma connective tissue growth factor against brain natriuretic peptide is a potential marker of myocardial fibrosis

N Koitabashi, M Arai, M Morita, S Hara, K Niwano, A Watanabe, M Kurabayashi, S Kubata, T Nishida, M Takigawa

CIRCULATION 112 ( 17 ) U787 - U787 2005.10

Connective tissue growth factor (CTGF/CCN2) enhanced human bone marrow stromall cell attachment in vitro and migration and survival of the cells in a hydroxyapatite scaffold in vivo.

M Ono, W Sonoyama, K Akiyama, T Fujisawa, T Nishida, M Takigawa, T Kuboki

JOURNAL OF BONE AND MINERAL RESEARCH 20 ( 9 ) S203 - S204 2005.9

Connective tissue growth factor (CTGF/CCN2) reinforces the molecular phenotype of aauricular chondrocytes in vitro.

T Fujisawa, K Nakao, T Hattori, S Kubota, T Kuboki, M Takigawa

JOURNAL OF BONE AND MINERAL RESEARCH 20 ( 9 ) S197 - S197 2005.9

Post-transcriptional regulation of CCN2/CTGF gene expression during differentiation of chicken chondrocytes: involvement of a putative trans-factor which interacts with a cis-element in the 3 '-UTR of mRNA

Y Mukudai, S Kubota, T Eguchi, S Kondo, K Nakao, M Takigawa

FEBS JOURNAL 272 284 - 285 2005.7

Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-β produced by tubular epithelial cells in response to high glucose

KOBAYASHI Tatsuya, INOUE Tsutomu, OKADA Hirokazu, KIKUTA Tomohiro, KANNO Yoshihiko, NISHIDA Takashi, TAKIGAWA Masaharu, SUGAYA Takeshi, SUZUKI Hiromichi

Clin Exp Nephrol 9 ( 2 ) 114 - 121 2005.6

Expression of CTGF/Hcs 24 during fracture healing and distraction osteogenesis

KIKUCHI Takeshi

16 134 - 134 2005.5

Cardiac Myocytes Regulates Collagen Production Through Connective Tissue Growth Factor Secretion Induced by Various Neurohumoral Factors(Molecular Biology, Myocardium 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Koitabashi Norimichi, Arai Masashi, Hara Shiro, Niwano Kazuo, Watanabe Atai, Kurabayashi Masahiko, Nishida Takashi, Takigawa Masaharu

Circulation journal : official journal of the Japanese Circulation Society 69 142 - 142 2005.3

CCN proteins: A new family of cell growth and differentiation regulators

Bernard Perbal, Masaharu Takigawa

CCN Proteins: A New Family of Cell Growth and Differentiation Regulators 1 - 311 2005.1

Language：English Publisher：Imperial College Press

The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely. CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.

DOI： 10.1142/P384

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デキサメタゾン刺激はCCN2/CTGFの誘導を介して軟骨細胞のリウマチ関連抗原HSP47/RA-A47の発現量を減少させるリウマチ病態および軟骨組織の修復との関連性について

矢尾真弓, 矢尾真弓, 服部高子, 川木晴美, 久保田聡, 油谷安孝, 佐々木朗, 滝川正春

Journal of Oral Biosciences 47 ( Supplement ) 2005

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