Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND/AIM: Malignant melanoma is a tumor with a poor prognosis that can metastasize distally at an early stage. Terrein, a metabolite produced by Aspergillus terreus, suppresses the expression of angiogenin, an angiogenic factor. However, the pharmacological effects of natural terrein have not been elucidated, because only a small amount of terrein can be extracted from large fungal cultures. In this study, we investigated the antineoplastic effects of terrein on human malignant melanoma cells and its underlying mechanisms. MATERIALS AND METHODS: Human malignant melanoma cell lines were cultured in the presence of terrein and analyzed. Angiogenin production was evaluated using ELISA. Ribosome biosynthesis was evaluated using silver staining of the nucleolar organizer region. Intracellular signaling pathways were analyzed using western blotting. Malignant melanoma cells were transplanted subcutaneously into the backs of nude mice. The tumors were removed at 5 weeks and analyzed histopathologically. RESULTS: Terrein inhibited angiogenin expression, proliferation, migration, invasion, and ribosome biosynthesis in malignant melanoma cells. Terrein was shown to inhibit tumor growth and angiogenesis in animal models. CONCLUSION: This study demonstrated that terrein has anti-tumor effects against malignant melanoma. Furthermore, chemically synthesized non-natural terrein can be mass-produced and serve as a novel potential anti-tumor drug candidate.

DOI： 10.21873/cgp.20464

PubMed

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Publishing type：Research paper (scientific journal)   Publisher：Graphyonline Publications PVT, Ltd.  

DOI： 10.15344/2456-4443/2017/128

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Language：English   Publishing type：Research paper (scientific journal)  

Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.

DOI： 10.18926/AMO/55204

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Language：English   Publishing type：Research paper (scientific journal)  

The aims of this study were to investigate how the Peer Assessment Rating (PAR index) predicts the perceived need for orthodontic treatment of mandibular protrusion in Japanese subjects, and to elucidate whether the perceived need for treatment was affected by the raters' orthodontic expertise. The subjects were 110 dental students and 32 orthodontists. We showed them casts of 10 untreated mandibular protrusion cases and gave them a questionnaire in which they had to describe their perceptions of the orthodontic treatment needs using a 10-point visual analog scale (VAS). The PAR index was used for cast evaluation. The PAR index scores showed significant correlations with the VAS scores. In casts with a low PAR score, there were no differences in the VAS scores between orthodontists and students. In casts with a PAR score greater than 23, the orthodontists perceived a significantly greater treatment need than did the students;for scores of 22, 28, and 29, students who had received orthodontic treatment themselves were more likely to perceive the treatment need. The PAR index is a good clinical predictor for assessing the perceived treatment needs for mandibular protrusion. Perception of the need for orthodontic treatment for mandibular protrusion depended on the degree of orthodontic expertise in Japanese subjects.

PubMed

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

今回われわれは,小腸転移により消化管穿孔をきたした上顎歯肉癌の1例を経験したので報告する。患者は86歳の男性で上顎骨部分切除術後の放射線治療中に腹痛を生じ,CTにて消化管穿孔が確認された。緊急手術が施行され,小腸腫瘍による穿孔を認めた。切除した腫瘍は歯肉癌の小腸転移と診断された。まれではあるが,進行頭頸部癌において腹部症状を訴えた場合,腹腔臓器への遠隔転移の可能性を考慮する必要があると考えられた。(著者抄録)

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Publisher：Oxford University Press (OUP)  

DOI： 10.1093/qjmed/hcad253

PubMed

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Language：Japanese   Publisher：(一社)日本口腔内科学会  

免疫抑制状態にある患者において,ガス壊疽は急激に進行し死に至ることもある。今回われわれは,関節リウマチ(RA)に対してプレドニゾロンおよびトシリズマブの投与を受けている78歳の女性に生じ,感染が急速に拡大したガス壊疽の1例を経験したので報告する。患者は,抜歯後3日目に路上で倒れているところを発見され当院へ救急搬送された。左側顎下部から前頸部に著明な発赤と腫脹および悪臭を認めた。患者はRAに対してプレドニゾロンならびにトシリズマブを定期投与中であり,易感染性状態であったために感染が急速に拡大したと考えられた。集中治療室入室後に救急科をはじめ関連各診療科と治療し全身麻酔下にデブリードマンを施行した。60病日目にリハビリテーション目的に転院となった。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J06061&link_issn=&doc_id=20230904270002&doc_link_id=10.6014%2Fjjsom.29.7&url=https%3A%2F%2Fdoi.org%2F10.6014%2Fjjsom.29.7&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：岡山歯学会  

60歳代女性。左乳癌再発、多発骨転移に対するデノスマブ(Dmab)使用により骨吸収抑制薬関連顎骨壊死(ARONJ)を生じた。下顎枝にいたる骨壊死と外歯瘻を認めたため、Stage 3のARONJと診断し腐骨除去術を行ったが治癒しなかった。画像所見で下顎骨下縁に溶解像を認めたため、右側下顎骨半側切除およびプレート再建術を行い顎機能の回復を図った。術後経過は良好で、術後3ヵ月後に下顎顎義歯を作製し使用している。

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Language：Japanese   Publisher：(公社)日本口腔外科学会  

81歳女性。左側頬粘膜からの持続性出血を主訴とした。口腔外所見で皮膚の斑状出血を、口腔内所見で口蓋粘膜の複数の血腫と出血を認めたこと、また、血液検査で著明な血小板数低値あったことより血小板減少症と診断した。血液疾患を疑って精査を行い、特発性血小板減少性紫斑病(ITP)と診断した。準救急治療を要すると判断し、即日入院して副腎皮質ステロイド療法を開始、第2病日よりトロンボポエチン受容体作動薬(TPO-RA)エルトロンボパグ経口投与を併用、血小板減少が進行したため第3病日に血小板輸血を行った。その結果、第5病日に完全止血が得られ、第17病日に退院した。退院後は血液内科と連携して外来にて副腎皮質ステロイドとエルトロンボパグの漸減管理を行い、エルトロンボパグは6ヵ月間の投与で終了、副腎皮質ステロイドとアレンドロン酸内服は継続中である。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J01073&link_issn=&doc_id=20211201450007&doc_link_id=10.5794%2Fjjoms.67.649&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.67.649&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif