Updated on 2025/04/24

写真a

 
Takebe Katsuki
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
External link

Research Interests

  • 構造活性相関

  • 口腔外科

  • 微生物学

  • X線結晶構造解析

  • 量子化学

  • 構造生物学

Research Areas

  • Life Science / Surgical dentistry

  • Life Science / Structural biochemistry

  • Life Science / Bacteriology

Research History

  • Okayama University   学術研究院医歯薬学域 歯科薬理学分野   Assistant Professor

    2024.4

    　 More details

  • Osaka University   Graduate School of Dentistry

    2020.4 - 2024.3

    　 More details

Professional Memberships

 

Papers

  • Identification of PilX, pilus component of Streptococcus sanguinis Reviewed

    Li Yixuan, Masanobu Nakata, Hirono Migita, Airi Matsumoto, Yuichi Oogai, Katsuki Takebe, Masaya Yamaguchi, Nobuo Okahashi, Tomoko Sumitomo, Shigetada Kawabata

    Journal of Oral Biosciences   100664 - 100664   2025.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.job.2025.100664

    researchmap

  • 9型分泌装置の構造と歯周病原細菌の病原性における意義 Reviewed

    武部克希

    ファルマシア   61 ( 3 )   257 - 257   2025.3

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese  

    DOI： 10.14894/faruawpsj.61.3_257

    researchmap

  • Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-kB and MAPK pathway Reviewed

    Kaung Htike, Kunihiro Yoshida, Takanori Eguchi, Katsuki Takebe, Xueming Li, Yaxin Qu, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto

    Journal of Oral Biosciences   2024.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.job.2024.09.007

    researchmap

  • New Catalytic Residues and Catalytic Mechanism of the RNase T1 Family Reviewed

    Katsuki Takebe, Mamoru Suzuki, Yumiko Hara, Takuya Katsutani, Naomi Motoyoshi, Tadashi Itagaki, Shuhei Miyakawa, Kuniaki Okamoto, Kaori Fukuzawa, Hiroko Kobayashi

    ACS Bio & Med Chem Au   2024.9

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsbiomedchemau.4c00046

    researchmap

  • Identification of the Acidification Mechanism of the Optimal pH for RNase He1 Reviewed

    Katsuki Takebe, Mamoru Suzuki, Takeshi Sangawa, Naomi Motoyoshi, Tadashi Itagaki, Kana Kashima, Narikazu Uzawa, Hiroko Kobayashi

    Biological and Pharmaceutical Bulletin   46 ( 12 )   1778 - 1786   2023.12

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan  

    DOI： 10.1248/bpb.b23-00511

    researchmap

  • Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms Reviewed

    Katsuki Takebe, Mamoru Suzuki, Takeshi Sangawa, Bernd Kreikemeyer, Masaya Yamaguchi, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata, Masanobu Nakata

    Archives of Microbiology   206 ( 1 )   2023.11

    　More details

    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00203-023-03727-1

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s00203-023-03727-1/fulltext.html

  • Reconstruction of the lower lip after resection of its venous malformation using a labial mucosal advancement flap – A case report- Reviewed

    Yoshio Ueno, Kazuhide Matsunaga, Akinori Takeshita, Akari Teramoto, Katsuki Takebe, Hitomi Kajikawa, Yoshihiro Morita, Narikazu Uzawa

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   35 ( 6 )   513 - 517   2023.11

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2023.03.004

    researchmap

  • Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O-Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses Reviewed

    Katsuki Takebe, Mamoru Suzuki, Takao Kuwada-Kusunose, Satoko Shirai, Kaori Fukuzawa, Tomoko Takamiya, Narikazu Uzawa, Hiroshi Iijima

    Journal of Chemical Information and Modeling   63 ( 14 )   4468 - 4476   2023.7

    　More details

    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.jcim.3c00331

    researchmap

  • Deep learning model for the automated evaluation of contact between the lower third molar and inferior alveolar nerve on panoramic radiography Reviewed

    Katsuki Takebe, Tomoaki Imai, Seiko Kubota, Ayano Nishimoto, Shigeki Amekawa, Narikazu Uzawa

    Journal of Dental Sciences   18 ( 3 )   991 - 996   2023.7

    　More details

    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jds.2022.12.008

    researchmap

  • GATA6 regulates expression of annexin A10 (ANXA10) associated with epithelial–mesenchymal transition of oral squamous cell carcinoma Reviewed

    Shun Takayama, Yoshihiro Morita, Ayano Nishimoto, Junya Nishimura, Katsuki Takebe, Satoko Kishimoto, Yuka Matsumiya-Matsumoto, Kazuhide Matsunaga, Tomoaki Imai, Narikazu Uzawa

    Archives of Oral Biology   144   105569 - 105569   2022.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.archoralbio.2022.105569

    researchmap

  • Novel Functional Peptide for Next-Generation Vital Pulp Therapy Reviewed

    M. Watanabe, M. Okamoto, S. Komichi, H. Huang, S. Matsumoto, K. Moriyama, J. Ohshima, S. Abe, M. Morita, M. Ali, K. Takebe, I. Kozaki, A. Fujimoto, K. Kanie, R. Kato, K. Uto, M. Ebara, A. Yamawaki-Ogata, Y. Narita, Y. Takahashi, M. Hayashi

    Journal of Dental Research   102 ( 3 )   322 - 330   2022.11

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    Although vital pulp therapy should be performed by promoting the wound-healing capacity of dental pulp, existing pulp-capping materials were not developed with a focus on the pulpal repair process. In previous investigations of wound healing in dental pulp, we found that organic dentin matrix components (DMCs) were degraded by matrix metalloproteinase-20, and DMC degradation products containing protein S100A7 (S100A7) and protein S100A8 (S100A8) promoted the pulpal wound-healing process. However, the direct use of recombinant proteins as pulp-capping materials may cause clinical problems or lead to high medical costs. Thus, we hypothesized that functional peptides derived from recombinant proteins could solve the problems associated with direct use of such proteins. In this study, we identified functional peptides derived from the protein S100 family and investigated their effects on dental pulp tissue. We first performed amino acid sequence alignments of protein S100 family members from several mammalian sources, then identified candidate peptides. Next, we used a peptide array method that involved human dental pulp stem cells (hDPSCs) to evaluate the mineralization-inducing ability of each peptide. Our results supported the selection of 4 candidate functional peptides derived from proteins S100A8 and S100A9. Direct pulp-capping experiments in a rat model demonstrated that 1 S100A8-derived peptide induced greater tertiary dentin formation compared with the other peptides. To investigate the mechanism underlying this induction effect, we performed liquid chromatography–tandem mass spectrometry analysis using hDPSCs and the S100A8-derived peptide; the results suggested that this peptide promotes tertiary dentin formation by inhibiting inflammatory responses. In addition, this peptide was located in a hairpin region on the surface of S100A8 and could function by direct interaction with other molecules. In summary, this study demonstrated that a S100A8-derived functional peptide promoted wound healing in dental pulp; our findings provide insights for the development of next-generation biological vital pulp therapies.

    DOI： 10.1177/00220345221135766

    researchmap

    Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/00220345221135766

  • Biofilm Spreading by the Adhesin-Dependent Gliding Motility of Flavobacterium johnsoniae: 2. Role of Filamentous Extracellular Network and Cell-to-Cell Connections at the Biofilm Surface Reviewed

    Keiko Sato, Masami Naya, Yuri Hatano, Naoki Kasahata, Yoshio Kondo, Mari Sato, Katsuki Takebe, Mariko Naito, Chikara Sato

    International Journal of Molecular Sciences   22 ( 13 )   6911 - 6911   2021.6

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Flavobacterium johnsoniae forms a thin spreading colony on nutrient-poor agar using gliding motility. As reported in the first paper, WT cells in the colony were sparsely embedded in self-produced extracellular polymeric matrix (EPM), while sprB cells were densely packed in immature biofilm with less matrix. The colony surface is critical for antibiotic resistance and cell survival. We have now developed the Grid Stamp-Peel method whereby the colony surface is attached to a TEM grid for negative-staining microscopy. The images showed that the top of the spreading convex WT colonies was covered by EPM with few interspersed cells. Cells exposed near the colony edge made head-to-tail and/or side-to-side contact and sometimes connected via thin filaments. Nonspreading sprB and gldG and gldK colonies had a more uniform upper surface covered by different EPMs including vesicles and filaments. The EPM of sprB, gldG, and WT colonies contained filaments ~2 nm and ~5 nm in diameter; gldK colonies did not include the latter. Every cell near the edge of WT colonies had one or two dark spots, while cells inside WT colonies and cells in SprB-, GldG-, or GldK-deficient colonies did not. Together, our results suggest that the colony surface structure depends on the capability to expand biofilm.

    DOI： 10.3390/ijms22136911

    researchmap

  • Crystal structure of the C-terminal domain of envelope protein VP37 from white spot syndrome virus reveals sulphate binding sites responsible for heparin binding Reviewed

    Wasusit Somsoros, Takeshi Sangawa, Katsuki Takebe, Jakrada Attarataya, Kanokpan Wongprasert, Saengchan Senapin, Triwit Rattanarojpong, Mamoru Suzuki, Pongsak Khunrae

    Journal of General Virology   102 ( 6 )   2021.6

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Microbiology Society  

    White spot syndrome virus (WSSV) is the most virulent pathogen causing high mortality and economic loss in shrimp aquaculture and various crustaceans. Therefore, the understanding of molecular mechanisms of WSSV infection is important to develop effective therapeutics to control the spread of this viral disease. In a previous study, we found that VP37 could bind with shrimp haemocytes through the interaction between its C-terminal domain and heparin-like molecules on the shrimp cells, and this interaction can also be inhibited by sulphated galactan. In this study, we present the crystal structure of C-terminal domain of VP37 from WSSV at a resolution of 2.51 Å. The crystal structure contains an eight-stranded β-barrel fold with an antiparallel arrangement and reveals a trimeric assembly. Moreover, there are two sulphate binding sites found in the position corresponding to R213 and K257. In order to determine whether these sulphate binding sites are involved in binding of VP37 to heparin, mutagenesis was performed to replace these residues with alanine (R213A and K257A), and the Surface Plasmon Resonance (SPR) system was used to study the interaction of each mutated VP37 with heparin. The results showed that mutants R213A and K257A exhibited a significant loss in heparin binding activity. These findings indicated that the sites of R213 and K257 on the C-terminal domain of envelope protein VP37 are essential for binding to sulphate molecules of heparin. This study provides further insight into the structure of C-terminal domain of VP37 and it is anticipated that the structure of VP37 might be used as a guideline for development of antivirus agent targeting on the VP37 protein.

    DOI： 10.1099/jgv.0.001611

    researchmap

  • Crystal Structure of Catechol -O-Methyltransferase Complexed with Nitecapone Reviewed

    Hiroshi Iijima, Katsuki Takebe, Mamoru Suzuki, Hiroko Kobayashi, Tomoko Takamiya, Hiroaki Saito, Norio Niwa, Takao Kuwada-Kusunose

    Chemical and Pharmaceutical Bulletin   68 ( 5 )   447 - 451   2020.5

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan  

    DOI： 10.1248/cpb.c20-00011

    researchmap

  • X-Ray Crystallographic Structure of Hericium erinaceus Ribonuclease, RNase He1 in Complex with Zinc Reviewed

    Hiroko Kobayashi, Takeshi Sangawa, Katsuki Takebe, Naomi Motoyoshi, Tadashi Itagaki, Mamoru Suzuki

    Biological and Pharmaceutical Bulletin   42 ( 12 )   2054 - 2061   2019.12

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Pharmaceutical Society of Japan  

    DOI： 10.1248/bpb.b19-00532

    researchmap

  • Immunoglobulin‐like domains of the cargo proteins are essential for protein stability during secretion by the type IX secretion system Reviewed

    Keiko Sato, Shinji Kakuda, Hideharu Yukitake, Yoshio Kondo, Mikio Shoji, Katsuki Takebe, Yuka Narita, Mariko Naito, Daisuke Nakane, Yoshimitsu Abiko, Koichi Hiratsuka, Mamoru Suzuki, Koji Nakayama

    Molecular Microbiology   110 ( 1 )   64 - 81   2018.10

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Summary

    The periodontal pathogen Porphyromonas gingivalis secretes many potent virulence factors using the type IX secretion system (T9SS). T9SS cargo proteins that have been structurally determined by X‐ray crystallography are composed of a signal peptide, functional domain(s), an immunoglobulin (Ig)‐like domain and a C‐terminal domain. Role of the Ig‐like domains of cargo proteins in the T9SS has not been elucidated. Gingipain proteases, which are cargo proteins of the T9SS, were degraded when their Ig‐like domains were lacking or truncated. The degradation was dependent on the activity of a quality control factor, HtrA protease. Another T9SS cargo protein, HBP35, which has a thioredoxin domain as a functional domain, was analyzed by X‐ray crystallography, revealing that HBP35 has an Ig‐like domain after the thioredoxin domain and that the hydrophobic regions of the thioredoxin domain and the Ig‐like domain face each other. HBP35 with substitution of hydrophobic amino acids in the Ig‐like domain was degraded depending on HtrA. These results suggest that the Ig‐like domain mediates stability of the cargo proteins in the T9SS.

    DOI： 10.1111/mmi.14083

    researchmap

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/mmi.14083

▼display all

MISC

  • Structural analysis of inactive hyaluronidase of Streptococcus pyogenes

    山口 雅也, 東 孝太郎, 武部 克希, 中田 匡宣, 住友 倫子, 川端 重忠

    日本細菌学雑誌   79 ( 2 )   268 - 268   2024.7

    　More details

    Language：English   Publisher：日本細菌学会  

    researchmap

  • Structure and antitumor activity of 12-residue variants of RNase He1 derived from Yamabushitake mushrooms.

    小林弘子, 武部克希, 千田正, 元吉尚美, 板垣正, 鵜澤成一, 鈴木守

    日本薬学会年会要旨集(Web)   144th   2024

    　More details

  • Reaction mechanism of COMT and conformational changes induced by enhancer molecules.

    武部克希, 桑田(楠瀬)隆生, 鈴木守, 飯島洋, 飯島洋

    日本薬学会年会要旨集(Web)   144th   2024

    　More details

  • COMT-Ligand Molecular Interactions Based on Crystal Structures and Quantum Chemical Calculations

    日本薬学会年会要旨集(Web)   144th   2024

    　More details

  • Streptococcus sanguinisが産生する線毛タンパク質のX線結晶構造解析

    武部 克希, 鈴木 守, 東 孝太郎, 山口 雅也, 住友 倫子, 川端 重忠, 中田 匡宣

    Journal of Oral Biosciences Supplement   2023   [P1 - 25]   2023.9

    　More details

    Language：Japanese   Publisher：(一社)歯科基礎医学会  

    researchmap

  • パノラマX線画像における下顎智歯-下歯槽管頬舌的位置関係の自動判定深層学習モデル構築の試み

    桂 尚[渕端], 武部 克希, 窪田 星子, 西元 彩乃, 今井 智章, 鵜澤 成一

    日本口腔科学会雑誌   72 ( 2 )   89 - 89   2023.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • Investigation of amino acid residues involved in the optimum pH of RNase He1 from Yamabushitake

    小林弘子, 武部克希, 元吉尚美, 板垣正, 鵜澤成一, 鈴木守

    日本薬学会年会要旨集(Web)   143rd   2023

    　More details

  • Conformational plasticity of catechol O-methyltransferase.

    飯島洋, 武部克希, 鈴木守, 桑田(楠瀬)隆生, 高宮知子, 鵜澤成一

    日本薬学会年会要旨集(Web)   143rd   2023

    　More details

  • ヤマブシタケ由来RNase He1改変体のX線構造解析と抗腫瘍活性

    武部克希, 千田正, 森田祥弘, 西村遵也, 西元彩乃, 鵜澤成一, 小林弘子

    日本口腔科学会学術集会プログラム・抄録集   77th   2023

    　More details

  • A study of the effectiveness of preoperative PCE chemotherapy for resectable oral cancer

    竹下彰範, 松永和秀, 森田祥弘, 松宮由香, 梶川ひとみ, 西元彩乃, 武部克希, 千田正, 柏木孝文, 加島佳奈, 紀之定紘子, 芝原巧, 菊池菫, 鵜澤成一

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   41st   2023

    　More details

  • Labial mucosal advancement flapを用いて口唇再建を行った下唇血管腫の1例

    寺本 朱里, 上野 祥夫, 松永 和秀, 竹下 彰範, 武部 克希, 梶川 ひとみ, 鵜澤 成一

    日本口腔科学会雑誌   71 ( 2 )   100 - 101   2022.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • X-Ray Crystallographic Structure of RNase He1 in Complex with guanosine from Hericium erinaceus (Yamabushitake)

    小林弘子, 寒川剛, 武部克希, 元吉尚美, 板垣正, 鵜澤成一, 鈴木守

    日本薬学会年会要旨集(Web)   142年会   28PO5 - 01   2022.3

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • パノラマX線画像における下顎智歯と下歯槽管接触の自動判定深層学習モデルの構築

    武部克希, 今井智章, 窪田星子, 窪田星子, 西元彩乃, 鵜澤成一

    日本口腔科学会雑誌(Web)   71 ( 1 )   2022

    　More details

  • Correspondence to postoperative recurrence and metastasis high risk cases in our department

    竹下彰範, 松永和秀, 加藤逸郎, 今井智章, 森田祥弘, 松宮由香, 千田正, 梶川ひとみ, 武部克希, 鵜澤成一

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   40th   2022

    　More details

  • Enhancement of COMT reaction by an enhancer compound: A crystallographic study.

    飯島洋, 武部克希, 桑田(楠瀬)隆生, 鈴木守, 高宮知子, 鵜澤成一

    日本薬学会年会要旨集(Web)   142nd   2022

    　More details

  • Crystal structures of COMT-opicapone complex: opicapone can form stable complexes either with SAM(substrate) and SAH(Product)

    武部克希, 桑田(楠瀬)隆夫, 鈴木守, 高宮知子, 鵜澤成一, 飯島洋

    日本薬学会年会要旨集(Web)   142nd   2022

    　More details

  • 化膿レンサ球菌の不活性型ヒアルロン酸分解酵素の結晶構造解析と活性型変異体の構造予測(Structural analysis of Streptococcus pyogenes hyaluronidase and in silico analysis based on structural models)

    東 孝太郎, 山口 雅也, 中田 匡宣, 武部 克希, 住友 倫子, 鈴木 守, 川端 重忠

    Journal of Oral Biosciences Supplement   2021   181 - 181   2021.10

    　More details

    Language：Japanese   Publisher：(一社)歯科基礎医学会  

    researchmap

  • 口腔癌の術前末梢血単核細胞を用いた腫瘍浸潤リンパ球のフェノタイプ予測

    梶川 ひとみ, 武部 克希, 松永 和秀, 鵜澤 成一

    日本口腔科学会雑誌   70 ( 2 )   145 - 145   2021.7

    　More details

    Language：Japanese   Publisher：(NPO)日本口腔科学会  

    researchmap

  • 口腔扁平上皮癌における腫瘍浸潤様式と腫瘍免疫学的因子の関連性の検討

    梶川 ひとみ, 武部 克希, 松永 和秀, 鵜澤 成一, 和田 尚

    日本がん免疫学会総会プログラム・抄録集   25回   111 - 111   2021.5

    　More details

    Language：Japanese   Publisher：日本がん免疫学会  

    researchmap

  • 口腔扁平上皮癌における腫瘍内T細胞と腫瘍浸潤様式の関連性

    梶川 ひとみ, 武部 克希, 松永 和秀, 鵜澤 成一

    頭頸部癌   47 ( 2 )   227 - 227   2021.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • 抗菌薬標的タンパク質の生化学 歯周病細菌叢の病原性を抑える試み

    佐藤 啓子, 納屋 昌実, 近藤 好夫, 武部 克希, 内藤 真理子, 鈴木 守, 今田 勝巳, 石川 岳志, 佐藤 主税

    日本細菌学雑誌   76 ( 1 )   40 - 40   2021.2

    　More details

    Language：Japanese   Publisher：日本細菌学会  

    researchmap

  • 微生物の分子論(遺伝子・タンパク質・情報伝達・代謝・各種オミクス等) 結晶構造解析に基づく化膿レンサ球菌におけるヒアルロン酸分解酵素の分子機構解明

    東 孝太郎, 山口 雅也, 中田 匡宣, 武部 克希, 住友 倫子, 鈴木 守, 川端 重忠

    日本細菌学雑誌   76 ( 1 )   53 - 53   2021.2

    　More details

    Language：Japanese   Publisher：日本細菌学会  

    researchmap

  • Structural analysis of Streptococcus pyogenes hyaluronidase and in silico analysis based on structural models

    Journal of Oral Biosciences Supplement (Web)   2021   2021

    　More details

  • Activated regulatory T cells correlates with mode of invasion in oral squamous cell carcinoma

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   39th   2021

    　More details

  • COMTと阻害剤の相互作用における官能基の寄与のFMO法による評価

    白井智子, 山本亜美, 古石誉之, 米持悦生, 武部克希, 鵜澤成一, 飯島洋, 福澤薫

    構造活性相関シンポジウム講演要旨集(CD-ROM)   49th   2021

    　More details

  • FMO法によるCOMTと阻害剤の相互作用におけるニトロ基の寄与の評価

    白井智子, 山本亜美, 古石誉之, 米持悦生, 武部克希, 飯島洋, 福澤薫

    日本薬学会関東支部大会講演要旨集(CD-ROM)   65th   2021

    　More details

  • Crystal structure of COMT/nitecapone complex and a suggestion for design of non-nitrocatechol type inhibitor.

    天野雅之, 武部克希, 鈴木守, 楠瀬隆生, 松本和樹, 茂庭歩美, 小林弘子, 齋藤弘明, 高宮知子, 丹羽典朗, 飯島洋

    日本薬学会年会要旨集(Web)   140年会   28K - pm05S   2020.3

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • COMT/阻害剤複合体の結晶構造解析及び,量子化学計算による相互作用解析

    武部克希, 福澤薫, 鈴木守, 桑田(楠瀬)隆生, 鵜澤成一, 飯島洋

    構造活性相関シンポジウム講演要旨集(CD-ROM)   48th   2020

    　More details

  • 9型分泌装置分泌タンパク質のImmunoglobulin-like domainsは細胞内構造安定性に関与する

    佐藤啓子, 角田真二, 武部克希, 鈴木守

    KEK Progress Report (Web)   ( 2019-7 )   2019

    　More details

  • 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質構造解析

    東 孝太郎, 武部 克希, 山口 雅也, 住友 倫子, 中田 匡宣, 鈴木 守, 川端 重忠

    Journal of Oral Biosciences Supplement   2018   351 - 351   2018.9

    　More details

    Language：Japanese   Publisher：(一社)歯科基礎医学会  

    J-GLOBAL

    researchmap

  • 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質構造解析

    東孝太郎, 武部克希, 山口雅也, 住友倫子, 中田匡宣, 鈴木守, 川端重忠

    Journal of Oral Biosciences Supplement (Web)   2018   2018

    　More details

  • Streptococcus sanguinisが産生するSrtCのX線結晶構造

    武部克希, 中田匡宣, 川端重忠, 鈴木守

    日本結晶学会年会講演要旨集   2018   2018

    　More details

  • ヤマブシタケ由来RNase He1のZn複合体のX線構造解析

    小林 弘子, 元吉 尚美, 板垣 正, 武部 克希, 寒川 剛, 鈴木 守

    日本薬学会年会要旨集   137年会 ( 3 )   129 - 129   2017.3

    　More details

    Language：Japanese   Publisher：(公社)日本薬学会  

    J-GLOBAL

    researchmap

  • 細胞接着因子Nectin-1/3ヘテロ複合体の立体構造解析

    寒川剛, 武部克希, 勝谷拓也, 鈴木守

    日本蛋白質科学会年会プログラム・要旨集   16th   2016

    　More details

  • M3型化膿レンサ球菌が産生する線毛タンパク質FctA3の結晶構造解析

    寒川剛, 武部克希, 中田匡宣, 川端重忠, 鈴木守

    日本結晶学会年会講演要旨集   2016   2016

    　More details

  • 細胞接着因子ネクチンのヘテロ複合体の結晶構造解析

    寒川剛, 武部克希, 勝谷拓也, 鈴木守

    日本結晶学会年会講演要旨集   2015   2015

    　More details

▼display all

Presentations

  • 細菌性コラゲナーゼの基質ほぐし及び切断機構について

    武部 克希, 美間 健彦, 沖 大也, 河原 一樹, 松下 治

    第77回日本細菌学会中国・四国支部総会  2024.10.6 

    　More details

    Event date： 2024.10.5 - 2024.10.6

    researchmap

  • COMT(カテコール-O-メチル基転移酵素)阻害剤の複合体 X 線結晶構造解析 及び、FMO(Fragment molecular orbital)法を用いた活性中心における 相互作用評価 Invited

    武部克希

    大阪大学歯学会 第 137 回例会 優秀研究奨励賞 受賞講演  2024.7.25 

    　More details

    Event date： 2024.7.25

    researchmap

  • RNase T1ファミリーの新規触媒残基および、RNase活性と抗腫瘍活性の関係性

    武部 克希, 宮川 柊兵, 原 由美子, 鈴木 守, 板垣 正, 元吉 尚美, 福澤 薫, 岡元 邦彰, 小林 弘子

    第41回創薬・薬理フォーラム岡山 

    　More details

    Event date： 2024.7.20

    Language：Japanese  

    researchmap

  • COMTの反応機構と賦活化物質による立体構造変化 Invited

    武部 克希, 桑田-楠瀬 隆生, 鈴木 守, 飯島 洋

    日本薬学会第144回  2024.3.30 

    　More details

    Event date： 2024.3.28 - 2024.3.31

    researchmap

  • パノラマ X 線画像における下顎智歯-下歯槽管接触関係の自動判定深層学習モデル構築の試み

    武部克希, 西元彩乃, 桂(渕端)尚, 窪田星子, 今井智章, 鵜澤成一

    .第68回 日本口腔外科学会 総会  2023.11.10 

    　More details

  • Streptococcus sanguinis が産生する線毛タンパク質のX線結晶構造解析

    武部 克希, 鈴木 守, 東 孝太郎, 山口 雅也, 住友 倫子, 川端 重忠, 中田 匡宣

    第65回歯科基礎医学会  2023.9.16 

    　More details

  • ヤマブシタケ由来 RNase He1 改変体のX 線構造解析と抗腫瘍活性

    武部克希, 千田正, 森田祥弘, 西村遵也, 西元彩乃, 鵜澤成一, 小林弘子

    第77回 日本口腔科学会  2023.5 

    　More details

  • Investigation of hydrogen bond network in the active center of catechol O-methyltransferase by X-ray crystallography and FMO method

    2022.10 

    　More details

  • パノラマ X 線画像における下顎智歯-下歯槽管接触関係の自動判定深層学習モデル構築の試み. Invited

    武部 克希, 今井 智章, 窪田 星子, 西元 彩乃, 鵜澤 成一

    第76回 日本口腔科学会  2022.4 

    　More details

  • COMT（カテコールO-メチル基転移酵素）-新規阻害剤の複合体の構造解析: Opicaponeは基質（SAM）、生成物（SAH）とも安定な複合体を形成する

    武部克希, 桑田(楠瀬) 隆夫, 鈴木 守, 高宮 知子, 鵜澤 成一, 飯島 洋

    日本薬学会第142年会  2022.3.27 

    　More details

  • パノラマX線画像における下顎智歯と下歯槽管接触の自動判定深層学習モデルの構築

    武部克希, 今井智章, 西元彩乃, 窪田星子, 鵜澤成一

    第33回日本口腔科学会近畿地方会  2021.12.6 

    　More details

  • COMT/阻害剤複合体の結晶構造解析及び、量子化学計算による相互作用解析

    武部克希, 福澤薫, 鈴木守, 楠瀬隆生, 鵜澤成一, 飯島洋

    第48 回構造活性相関シンポジウム  2020.12.10 

    　More details

▼display all

Awards

  • 第46回 両備檉園記念財団 奨励賞

    2024.10   両備檉園記念財団   サングイニスレンサ球菌の線毛連結機構を基にした薬剤開発

    　More details

  • 令和5年度 大阪大学歯学会 優秀研究奨励賞

    2024.7   大阪大学 歯学会  

    　More details

  • 令和5年度 研究科長賞（最優秀賞）

    2024.3   大阪大学  

    　More details

  • 第33回日本口腔科学会近畿地方部会 新人賞

    2022.4   口腔科学会  

    　More details

  • 令和3年度 研究科長賞（奨励賞)

    2022.4   大阪大学  

    　More details

Research Projects

  • レンサ球菌線毛先端蛋白質の構造解析に立脚した細胞付着機構の解明及び感染制御創薬

    Grant number：25K20246  2025.04 - 2026.03

    日本学術振興会  科学研究費助成事業  若手研究

    武部 克希

    　 More details

    Authorship：Principal investigator 

    researchmap

  • サングイニスレンサ球菌の線毛連結機構を基にした薬剤開発

    2024.10

    両備檉園記念財団  第46回 両備檉園記念財団 奨励賞

    武部 克希

    　 More details

    Authorship：Principal investigator 

    researchmap

  • サングイニスレンサ球菌の線毛連結機構の解明及び、連結阻害に基づく感染制御の創薬

    Grant number：24K23551  2024.07 - 2026.03

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    武部 克希

    　 More details

    Authorship：Principal investigator 

    Grant amount：\2860000 （ Direct expense: \2200000 、 Indirect expense：\660000 ）

    researchmap

  • 歯周病細菌主要病原因子ジンジパインの宿主直接作用と必須新奇オペロンの解明

    Grant number：24K02614  2024.04 - 2028.03

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    大原 直也

    　 More details

    Grant amount：\18590000 （ Direct expense: \14300000 、 Indirect expense：\4290000 ）

    researchmap

  • 膜ダイナミクスをターゲットとしたがん骨転移ニッチモデルと病態制御機構の開発

    Grant number：24K13239  2024.04 - 2027.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    岡元 邦彰

    　 More details

    Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

    researchmap

  • Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation

    Grant number：23K28000  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    江口 傑徳, 高橋 賢, 河合 穂高, 岡元 邦彰, 冨樫 庸介, 武部 克希

    　 More details

    Grant amount：\18720000 （ Direct expense: \14400000 、 Indirect expense：\4320000 ）

    researchmap

▼display all

 

Class subject in charge

  • From molecules to organisms （2024academic year） Third semester  - 金5～6