研究者詳細 - 中司　敦子

論文 - 中司　敦子

分割表示 101 件中 81 - 100 件目／全件表示 >>

Galectin-9 inhibits the development of type 1 diabetes in female NOD mice

Motoko Kanzaki, Jun Wada, Atsuko Nakatsuka, Kazutoshi Murakami, Sanae Teshigawara, Takahiro Terami, Kentaro Inoue, Hirofumi Makino

DIABETES 57 A78 - A78 2008年6月

Serum vaspin levels correlate with the accumulation of visceral adipose tissues in type 2 diabetes patients

Sanae Teshigawara, Jun Wada, John Mcdonald, Jehangir Mistry, Atsuko Nakatsuka, Kazutoshi Murakami, Motoko Kanzaki, Takahiro Terami, Kentaro Inoue, Hirofumi Makino

DIABETES 57 A394 - A395 2008年6月

Procollagen C-proteinase enhancer-1 (POPE-1) interacts with beta 2-microglobulin (beta 2-m) and may help initiate beta 2-m amyloid fibril formation in connective tissues 査読

Hisanori Morimoto, Jun Wada, Bernard Font, Joni D. Mott, David J. S. Hulmes, Tadakazu Ookoshi, Hironobu Naiki, Akihiro Yasuhara, Atsuko Nakatsuka, Kousuke Fukuoka, Yuji Takatori, Haruo Ichikawa, Shigeru Akagi, Kazushi Nakao, Hirofumi Makino

MATRIX BIOLOGY 27 ( 3 ) 211 - 219 2008年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

Dialysis related amyloidosis (DRA) is a progressive and serious complication in patients under long-term hemodialysis and mainly leads to osteo-articular diseases. Although beta 2-microglobulin (beta 2-m) is the major structural component of beta 2-m amyloid fibrils, the initiation of amyloid formation is not clearly understood. Here, we have identified procollagen C-proteinase enhance-1 (POPE-1) as a new interacting protein with beta 2-m by screening a human synovium cDNA library. The interaction of beta 2-m with full-length POPE-1 was confirmed by immunoprecipitation, solid-phase binding and pull-down assays. By yeast two-hybrid analysis and pull-down assay, beta 2-m appeared to interact with POPE-1 via the NTR (netrin-like) domain and not via the CUB (C1r/C1s, Uegf and BMP-1) domain region. In synovial tissues derived from hemodialysis patients with DRA, beta 2-m co-localized and formed a complex with POPE-1. beta 2-m did not alter the basal activity of bone morphogenetic protein-1/procollagen C-proteinase (BMP-1/PCP) nor BMP-1/PCP activity enhanced by PCPE-1. PCPE-1 did not stimulate beta 2-m amyloid fibril formation from monomeric beta 2-m in vitro under acidic and neutral conditions as revealed by thioflavin T fluorescence spectroscopy and electron microscopy. Since PCPE-1 is abundantly expressed in connective tissues rich in type I collagen, it may be involved in the initial accumulation of beta 2-m in selected tissues such as tendon, synovium and bone. Furthermore, since such preferential deposition of beta 2-m may be linked to subsequent beta 2-m amyloid fibril formation, the disruption of the interaction between beta 2-m and POPE-1 may prevent beta 2-m amyloid fibril formation and therefore POPE-1 could be a new target for the treatment of DRA. (C) 2007 Elsevier B.V./International Society of Matrix Biology. All rights reserved.

DOI： 10.1016/j.matbio.2007.11.005

Web of Science

PubMed

researchmap

ヒト血中Vaspin濃度の検討とメタボリックシンドロームにおける意義

勅使川原早苗, 和田淳, 中司敦子, 村上和敏, 肥田和之, 伊勢田泉, 利根淳仁, 松下裕一, 宮武伸行, 井上謙太郎, 寺見隆宏, 四方賢一, 槇野博史

糖尿病 51 ( Suppl.1 ) S - 308 2008年4月

Galectin-9による1型糖尿病発症抑制の検討

神崎資子, 和田淳, 吉川理津子, 中司敦子, 村上和敏, 安原章浩, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 四方賢一, 槇野博史

糖尿病 51 ( Suppl.1 ) S - 211 2008年4月

ACAMの脂肪分化とメタボリックシンドロームにおける意義

村上和敏, 和田淳, 中司敦子, 神崎資子, 安原章浩, 吉川理津子, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 四方賢一, 槇野博史

糖尿病 51 ( Suppl.1 ) S - 306 2008年4月

Vaspinのメタボリックシンドロームにおける意義

中司敦子, 和田淳, 村上和敏, 神崎資子, 安原章浩, 吉川理津子, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 四方賢一, 槇野博史

糖尿病 51 ( Suppl.1 ) S - 307 2008年4月

Adipocyte adhesion molecule (ACAM) inhibits adipocyte hypertrophy in obesity

K. Murakami, J. Wada, A. Nakatsuka, S. Teshigawara, R. Yoshikawa, M. Kanzaki, A. Yasuhara, K. Shikata, H. Makino

DIABETOLOGIA 50 S57 - S57 2007年9月

Vaspin improves insulin sensitivity in obesity

A. Nakatsuka, J. Wada, K. Murakami, S. Teshigawara, R. Yoshikawa, M. Kanzaki, A. Yasuhara, K. Shikata, H. Makino

DIABETOLOGIA 50 S56 - S56 2007年9月

脂肪細胞分化 ACAMトランスジェニックマウスとメタボリック症候群

村上和敏, 和田淳, 中司敦子, 神崎資子, 勅使川原早苗, 四方賢一, 槇野博史

肥満研究 13 ( Suppl. ) 157 - 157 2007年9月

Vaspinとメタボリック症候群

中司敦子, 和田淳, 村上和敏, 神崎資子, 勅使川原早苗, 四方賢一, 槇野博史

肥満研究 13 ( Suppl. ) 193 - 193 2007年9月

Vaspin(visceral adipose tissue-derived serpin)とインスリン抵抗性

中司敦子, 和田淳, 村上和敏, 勅使川原早苗, 吉川理津子, 神崎資子, 四方賢一, 槇野博史

糖尿病 50 ( Suppl.1 ) S - 166 2007年4月

Adipocyte adhesion molecule(ACAM)トランスジェニックマウスとメタボリックシンドローム

村上和敏, 和田淳, 中司敦子, 勅使川原早苗, 吉川理津子, 神崎資子, 安原章浩, 四方賢一, 槇野博史

糖尿病 50 ( Suppl.1 ) S - 163 2007年4月

Hemophagocytic syndrome associated with fatal veno-occlusive disease in the liver 査読

Atsuko Nakatsuka, Jun Wada, Ryo Nagase, Masaya Takeda, Tadashi Yoshino, Hirofumi Makino

INTERNAL MEDICINE 46 ( 8 ) 495 - 499 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 47-year-old man presented with hemophagocytic syndrome (HPS) without any obvious underlying diseases. On computed tomography, his liver was occupied by multiple ill-defined low intensity lesions. Liver biopsy revealed diffuse infiltration of numerous histiocytes without cytologic atypism and prominent fibrotic changes. These histiocyes showed S100(+), CD68(+), CD1a(-), and lysozyme(+) and Langerhans cell granules were not observed by electron microscopic examination. He failed to respond to immunosuppressive and chemotherapeutic treatments and progressed to severe liver failure. At autopsy, his liver exhibited veno-occulusive disease (VOD). Since VOD is regarded as a rare complication of HPS, the presence of VOD associated with HPS may be easily overlooked.

DOI： 10.2169/internalmedicine.46.6294

Web of Science

PubMed

researchmap

[Molecular biology of regulation in renal functions; biosynthesis, metabolism, and action of insulin and glucagon]. 査読

Nakatsuka A, Wada J, Makino H

Nihon rinsho. Japanese journal of clinical medicine 64 Suppl 2 222 - 226 2006年2月

Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity 査読

K Hida, J Wada, J Eguchi, H Zhang, M Baba, A Seida, L Hashimoto, T Okada, A Yasuhara, A Nakatsuka, K Shikata, S Hourai, J Futami, E Watanabe, Y Matsuki, R Hiramatsu, S Akagi, H Makino, YS Kanwar

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 ( 30 ) 10610 - 10615 2005年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATL ACAD SCIENCES

There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue-derived serpin (vaspin), which is a member of serine protease inhibitor family. Vaspin cDNA was isolated by from visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETIF) rat, an animal model of abdominal obesity with type 2 diabetes. Rat, mouse, and human vaspins are made up of 392,394, and 395 amino acids, respectively; exhibit approximate to 40% homology with alpha(1)-antitrypsin; and are related to serine protease inhibitor family. Vaspin was barely detectable in rats at 6 wk and was highly expressed in adipocytes of visceral WATs at 30 wk, the age when obesity, body weight, and insulin levels peak in OLETF rats. The tissue expression of vaspin and its serum levels decrease with worsening of diabetes and body weight loss at 50 wk. The expression and serum levels were normalized with the treatment of insulin or insulin-sensitizing agent, pioglitazone, in OLETF rats. Administration of vaspin to obese CRL:CD-1 (ICR) (ICR) mice fed with high-fat high-sucrose chow improved glucose tolerance and insulin sensitivity reflected by normalized serum glucose levels. It also led to the reversal of altered expression of genes relevant to insulin resistance, e.g., leptin, resistin, TNF alpha, glucose transporter-4, and adiponectin. In DNA chip analyses, vaspin treatment resulted in the reversal of expression in approximate to 50% of the high-fat high-sucrose-induced genes in WATs. These findings indicate that vaspin exerts an insulin-sensitizing effect targeted toward WATs in states of obesity.

DOI： 10.1073/pnas.0504703102

Web of Science

PubMed

researchmap

A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. 査読

Nakatsuka A, Maeshima Y, Sarai A, Yanai H, Sugiyama H, Yamasaki Y, Makino H

Clin Nephrol 64 221 - 227 2005年

VASPIN(visceral adipose tissue specific SERPIN)とインスリン抵抗性

肥田和之, 和田淳, 江口潤, 松岡孝至, 橋本泉, 安原章浩, 中司敦子, 清田綾, 岡田達夫, 馬場雅子, 四方賢一, 槇野博史

糖尿病 47 ( Suppl.1 ) S252 - S252 2004年4月

糖尿病性腎症に対するPioglitazoneの作用メカニズムの検討

岡田達夫, 和田淳, 肥田和之, 江口潤, 橋本泉, 馬場雅子, 松岡孝至, 安原章浩, 清田綾, 中司敦子, 四方賢一, 槇野博史

糖尿病 47 ( Suppl.1 ) S195 - S195 2004年4月

白色脂肪特異的新規膜蛋白(OL-16)の機能解析

江口潤, 和田淳, 肥田和之, 松岡孝至, 馬場雅子, 中司敦子, 橋本泉, 清田綾, 安原章浩, 岡田達夫, 四方賢一, 槇野博史

肥満研究 9 ( Suppl. ) 76 - 76 2003年10月

　前のページ - 次のページ　

<中司 敦子>

論文 - 中司 敦子

<中司　敦子>

論文 - 中司　敦子