研究者詳細 - 中司　敦子

Telmisartan attenuates diabetic nephropathy by suppressing oxidative stress in db/db mice. 査読国際誌

Sato-Horiguchi C, Ogawa D, Wada J, Tachibana H, Kodera R, Eguchi J, Nakatsuka A, Terami N, Shikata K, Makino H

Nephron. Experimental nephrology 121 ( 3-4 ) e97 - e108 2012年

A Case of Type 2 Diabetes and Metastatic Liver Cancer Exhibiting Hypercholesterolemia with Abnormal Lipoproteins 査読

Motoko Kanzaki, Jun Wada, Atsuko Nakatsuka, Sanae Teshigawara, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Junichiro Nasu, Kazuhide Yamamoto, Hirofumi Makino

INTERNAL MEDICINE 51 ( 6 ) 619 - 623 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.

DOI： 10.2169/internalmedicine.51.6486

Telmisartan Attenuates Diabetic Nephropathy by Suppressing Oxidative Stress in db/db Mice 査読

Chikage Sato-Horiguchi, Daisuke Ogawa, Jun Wada, Hiromi Tachibana, Ryo Kodera, Jun Eguchi, Atsuko Nakatsuka, Naoto Terami, Kenichi Shikata, Hirofumi Makino

NEPHRON EXPERIMENTAL NEPHROLOGY 121 ( 3-4 ) E97 - E108 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KARGER

Background/Aims: Telmisartan, an angiotensin II type 1 receptor blocker, is widely used to treat hypertension and kidney diseases, including diabetic nephropathy, because of its renoprotective effects. However, the mechanism by which telmisartan prevents proteinuria and renal dysfunction in diabetic nephropathy is still unclear. In this study, we examined the effects of telmisartan against diabetic nephropathy in db/db mice. Methods: Telmisartan was administered at a dose of 5 mg/kg/day for 3 weeks to db/db (diabetic) and db/m (control) mice. Urinary albumin excretion, renal histology, and the gene expression of oxidative stress and inflammatory markers in renal tissue were determined. To evaluate the effects of telmisartan on reactive oxygen species (ROS) production, superoxide was detected by dihydroethidium (DHE) staining in vivo and in vitro. Results: Telmisartan reduced albuminuria, mesangial matrix expansion, macrophage infiltration, and the expression of ROS markers (NADPH oxidase 4- and 8-hydroxydeoxyguanosine) and inflammatory cytokines (monocyte chemoattractant protein-1, osteopontin, and transforming growth factor-beta) in the kidney. DHE staining showed that telmisartan decreased ROS generation in the kidney and in cultured mesangial and proximal tubular epithelial cells. Conclusions: Taken together, these findings indicate that telmisartan protects against diabetic nephropathy by reducing diabetes-induced oxidative stress. Copyright (c) 2013 S. Karger AG, Basel

DOI： 10.1159/000343102

Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations 査読

Akihiro Katayama, Jun Wada, Hitomi Usui Kataoka, Hiroko Yamasaki, Sanae Teshigawara, Takahiro Terami, Kentaro Inoue, Motoko Kanzaki, Kazutoshi Murakami, Atsuko Nakatsuka, Hitoshi Sugiyama, Norio Koide, Hideaki Bujo, Hirofumi Makino

NDT Plus 4 ( 5 ) 299 - 302 2011年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Familial lecithin:cholesterol acyltransferase deficiency (FLD) is an autosomal recessive disorder characterized by corneal opacity, hemolytic anemia, low high-density lipoprotein cholesterol (HDL-C) and proteinuria. Two novel lecithin:cholesterol acyltransferase (LCAT) mutations[c.278 C&gt
T (p.Pro69Leu)
c.950 T&gt
C (p.Met293Thr)] were identified in a 27-year-old man and in a 30-year-old woman, respectively. Both patients manifested corneal opacity, hemolytic anemia, low low-density lipoprotein cholesterol and HDL-C and proteinuria. Lipid deposits with vacuolar lucent appearance in glomerular basement membranes were observed in both cases. APOE genotype was also investigated: the first case results ε4/ε3, the second ε2/ε2
however, they shared a similar phenotype characterized by the presence of intermediate-density lipoproteins (IDL) remnant and the absence of lipoprotein-X. In conclusion, our findings suggest that APOE ε2/ε2 may not be the major determinant gene for the appearance of IDL in FLD patients. © 2011 The Author.

DOI： 10.1093/ndtplus/sfr091

Scopus

[Obesity: Progress in diagnosis and treatment; Topics, IV. Recent topics: 3. Obesity and new secretory factors; 1) Vaspin]. 査読

Wada J, Teshigawara S, Nakatsuka A, Makino H

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 100 ( 4 ) 996 - 1001 2011年4月

記述言語：日本語出版者・発行元：The Japanese Society of Internal Medicine

バスピン（vaspin）は肥満ラットの内臓脂肪から発見されたアディポサイトカインである．肥満マウスへのリコンビナント蛋白の投与実験から肥満症におけるインスリン抵抗性を改善する代償因子であると考えている．バスピンはヒトの血中にも存在し，肥満症においては体格指数，インスリン抵抗性指数と正相関を認めるとの報告が多い．また2型糖尿病でも血中濃度が増加し，女性で高値である．アディポネクチンやレプチンとは異なった血中濃度動態を示しており肥満症治療の新たな分子ターゲットである．<br>

DOI： 10.2169/naika.100.996

その他リンク： https://jlc.jst.go.jp/DN/JALC/00368341128?from=CiNii

新規脂肪細胞膜蛋白Gpnmbの同定

片山晶博, 和田淳, 中司敦子, 村上和敏, 神崎資子, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 肥田和之, 四方賢一, 槇野博史

糖尿病 54 ( Suppl.1 ) S - 356 2011年4月

ACAMの脂肪分化とメタボリックシンドロームにおける意義

村上和敏, 和田淳, 中司敦子, 神崎資子, 勅使川原早苗, 寺見隆宏, 井上謙太郎, 片山晶博, 四方賢一, 槇野博史

糖尿病 54 ( Suppl.1 ) S - 132 2011年4月

糖尿病性腎症の糖鎖プロファイングの検討

井上謙太郎, 和田淳, 中司敦子, 村上和敏, 神崎資子, 寺見隆宏, 勅使川原早苗, 黒瀬祐子, 片山晶博, 小川智央, 山田雅雄, 四方賢一, 槇野博史

糖尿病 54 ( Suppl.1 ) S - 225 2011年4月

[Chemerin, RBP4 and vaspin]. 査読

Wada J, Teshigawara S, Nakatsuka A

Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 1 231 - 236 2011年1月

メタボリック症候群・慢性腎臓病の核内受容体をターゲットとした治療

中司敦子, 和田淳, 影近弘之, 肥田和之, 村上和敏, 神崎資子, 勅使川原早苗, 寺見隆宏, 井上謙太郎, 小川大輔, 四方賢一, 槇野博史

日本腎臓学会誌 52 ( 3 ) 321 - 321 2010年5月

メタボリック症候群・慢性腎臓病の核内受容体をターゲットとした治療

和田淳, 中司敦子, 影近弘之, 肥田和之, 村上和敏, 神崎資子, 勅使川原早苗, 寺見隆宏, 井上謙太郎, 小川大輔, 四方賢一, 槇野博史

糖尿病 53 ( Suppl.1 ) S - 251 2010年4月

RXRアンタゴニストによる細胞周期異常制御とメタボリック症候群

中司敦子, 和田淳, 村上和敏, 神崎資子, 勅使川原早苗, 井上謙太郎, 寺見隆宏, 黒瀬祐子, 四方賢一, 影近弘之, 槇野博史

糖尿病 52 ( Suppl.1 ) S - 246 2009年4月

ACAMの脂肪分化とメタボリックシンドロームにおける意義

村上和敏, 和田淳, 中司敦子, 勅使川原早苗, 神崎資子, 吉川理津子, 寺見隆宏, 井上謙太郎, 黒瀬祐子, 四方賢一, 槇野博史

糖尿病 52 ( Suppl.1 ) S - 162 2009年4月

ヒト血中Vaspin濃度の検討とメタボリックシンドロームにおける意義

勅使川原早苗, 和田淳, 中司敦子, 村上和敏, 神崎資子, 肥田和之, 伊勢田泉, 利根淳仁, 松下裕一, 宮武伸行, 井上謙太郎, 寺見隆宏, 黒瀬裕子, 四方賢一, 槇野博史

糖尿病 52 ( Suppl.1 ) S - 245 2009年4月

Collectrin Is Involved in the Development of Salt-Sensitive Hypertension by Facilitating the Membrane Trafficking of Apical Membrane Proteins via Interaction With Soluble N-Ethylmaleiamide-Sensitive Factor Attachment Protein Receptor Complex 査読

Akihiro Yasuhara, Jun Wada, Sandra M. Malakauskas, Yanling Zhang, Jun Eguchi, Atsuko Nakatsuka, Kazutoshi Murakami, Motoko Kanzaki, Sanae Teshigawara, Kazuya Yamagata, Thu H. Le, Hirofumi Makino

CIRCULATION 118 ( 21 ) 2146 - 2155 2008年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Background-Collectrin, a homologue of angiotensin converting enzyme 2, is expressed in pancreatic beta cells and renal proximal tubular and collecting duct cells under the control of hepatocyte nuclear factors-1 alpha and-1 beta. Because collectrin interacts with the soluble N-ethylmaleiamide-sensitive factor attachment protein receptor (SNARE) complexes, we investigated whether collectrin is involved in sodium handling in hypertension by vesicle trafficking of apical membrane proteins.
Methods and Results-Collectrin physically interacts with the SNARE complex: snapin, synaptosomal-associated protein 23 kDa, syntaxin-4, and vesicle-associated membrane protein-2 in mIMCD-3 cells. siRNA knockdown of collectrin resulted in a reduction in membrane-associated aquaporin-2, alpha-epithelial Na(+) channel, and H(+)-ATPase. Collectrin and SNARE proteins were abundantly expressed in collecting ducts of Wistar-Kyoto rats. Wistar-Kyoto rats and spontaneously hypertensive rats 7 weeks of age were subjected to normal-salt (1% NaCl) and high-salt (8% NaCl) chow for 10 weeks. High-salt chow prominently elevated blood pressure, oral intake, and urinary excretion of NaCl and water in both groups. Although urinary excretion of aldosterone was significantly suppressed in both groups, collectrin expression was upregulated and associated with the maintenance of aquaporin-2, alpha-epithelial Na(+) channel, and H(+)-ATPase in membrane fractions. Collectrin promoter activities and mRNA and protein expressions were upregulated and ubiquitinated collectrin was reduced by high NaCl (175 to 225 mmol/L) and not altered by 1 mu mol/L aldosterone in mIMCD-3 cells.
Conclusions-Upregulation of collectrin by high NaCl independent of aldosterone functionally links to the trafficking of apical membrane proteins via the SNARE complex, and collectrin may be responsible for the sodium retention in salt-sensitive hypertension. (Circulation. 2008; 118: 2146-2155.)

DOI： 10.1161/CIRCULATIONAHA.108.787259