2021/10/21 更新

写真a

ヒサマツ タカシ
久松 隆史
HISAMATSU Takashi
所属
医歯薬学域 准教授
職名
准教授
外部リンク

学位

  • 博士(医学) ( 滋賀医科大学 )

研究キーワード

  • 公衆衛生

  • 循環器疾患

  • メタボローム

  • オミクス

  • メンデルランダム化

  • 予防医学

  • 腸内細菌

  • 疫学

  • 高血圧

研究分野

  • ライフサイエンス / 循環器内科学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 医療管理学、医療系社会学

学歴

  • 滋賀医科大学   大学院医学系研究科  

    2009年4月 - 2013年3月

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    国名: 日本国

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  • 滋賀医科大学   医学部   医学科

    - 2003年

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    国名: 日本国

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経歴

  • 岡山大学   学術研究院医歯薬学域   准教授

    2020年1月 - 現在

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  • 日本学術振興会海外特別研究員 Northwestern University Feinberg School of Medicine(留学)

    2017年2月 - 2019年1月

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  • 滋賀医科大学   社会医学講座公衆衛生学部門   客員准教授

    2016年4月 - 現在

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  • 島根大学医学部   環境保健医学講座   准教授

    2016年4月 - 2019年12月

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  • 滋賀医科大学   アジア疫学研究センター   特任助教

    2013年4月 - 2016年3月

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  • Northwestern University Feinberg School of Medicine   非常勤講師

    2019年2月

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  • 滋賀医科大学   循環器内科   医員

    2011年4月 - 2013年3月

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  • 大阪回生病院   循環器内科   医員

    2008年4月 - 2011年3月

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  • 日本赤十字社長浜赤十字病院   循環器内科   医員

    2005年6月 - 2008年3月

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  • 滋賀医科大学医学部附属病院   内科   医員

    2003年5月 - 2005年5月

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所属学協会

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委員歴

  • 倉敷市保健所   医療コーディネーター(新型コロナウィルス対策班)  

    2021年9月   

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  • 医療系大学間共用試験実施評価機構医学系CBT実施小委員会   ブラッシュアップ専門部会委員  

    2021年6月   

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  • 岡山県新型コロナウィルスクラスター対策班   専門家  

    2020年9月   

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  • 健康市民おかやま21推進会議   評価部会委員  

    2020年7月   

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  • 日本動脈硬化学会   評議員  

    2019年   

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    団体区分:学協会

    日本動脈硬化学会

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  • Korean Circulation Journal   編集委員  

    2017年   

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    団体区分:学協会

    The Korean Society of Cardiology (Korea)

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  • 日本循環器病予防学会   評議員  

    2017年   

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    団体区分:学協会

    日本循環器病予防学会

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  • 島根県出雲市脳卒中予防対策検討会議   委員  

    2019年   

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  • 島根県感染症発生動向調査委員会   委員  

    2019年   

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  • 島根県出雲圏域健康長寿しまね推進会議   委員  

    2019年   

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  • 島根県保健環境科学研究所・原子力環境センター調査研究課題検討委員会   委員  

    2019年   

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論文

  • Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. 査読 国際誌

    Takashi Hisamatsu, Donald M Lloyd-Jones, Laura A Colangelo, Kiang Liu

    Journal of hypertension   39 ( 8 )   1586 - 1593   2021年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Data are sparse regarding the impact of sodium and potassium intakes on serial blood pressure (BP) levels during long-term follow-up. METHODS: Among 1007 Coronary Artery Risk Development in Young Adults participants (mean age, 30.2 years; 53% blacks; 57% women) who had at least two 24-h urine samples collected at year 5 (Y5) examination, we assessed associations of urinary sodium and potassium excretions with BP trends and incident hypertension in the subsequent 25 years. Participants were classified by sex-specific medians for averaged 24-h urinary excretions: lower sodium and higher potassium (Na-Lo-K-Hi); higher sodium and lower potassium (Na-Hi-K-Lo); and others. RESULTS: In the adjusted generalized estimating equation model, SBP and DBP greatly increased in the Na-Hi-K-Lo group (n = 185) compared with the Na-Lo-K-Hi group (n = 185), with statistically significant BP differences at Y20, Y25, and Y30 (mean SBP, 3.93, 4.94, and 4.88 mmHg, respectively; and mean DBP, 4.70, 4.95, and 4.59 mmHg, respectively). During 25-year follow-up, among 926 participants without prevalent hypertension by Y5, 381 (41.1%) developed hypertension. In the adjusted Cox proportional hazards model, the Na-Hi-K-Lo group had hazard ratio (95% confidence interval), 1.45 (1.00-2.10) for incident hypertension compared with the Na-Lo-K-Hi group. The association with incident hypertension was predominant in blacks and white women (race--sex interaction, P = 0.03). Sodium-to-potassium ratio and sodium excretion were positively, whereas potassium excretion was inversely, associated with incident hypertension (all P trend <0.05). CONCLUSION: Our findings highlight the importance of dietary sodium reduction and higher potassium intake for hypertension prevention among young adults.

    DOI: 10.1097/HJH.0000000000002802

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  • Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis. 査読 国際誌

    Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of hypertension   Publish Ahead of Print   2021年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.

    DOI: 10.1097/HJH.0000000000002900

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  • Relationship between insomnia with alcohol drinking before sleep (Ne-Zake) or in the morning (Mukae-Zake) among Japanese farmers. 査読 国際誌

    Rie Sato, Takashi Hisamatsu, Hideki Tsumura, Mari Fukuda, Kaori Taniguchi, Haruo Takeshita, Hideyuki Kanda

    Alcohol (Fayetteville, N.Y.)   93   57 - 62   2021年6月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Ne-Zake is the drinking of alcohol before sleeping for helping to fall asleep and sleep well, and Mukae-Zake is the drinking of alcohol in the morning for "calming down" or "curing hangovers". OBJECTIVE: We sought to examine the relationship of insomnia with Ne-Zake and Mukae-Zake among healthy middle-aged Japanese farmers. METHODS: In a cross-sectional study of 746 participants (mean age, 59.5 years; women, 25.9%), Ne-Zake and Mukae-Zake were defined based on a self-administered questionnaire. Insomnia was defined as the Athens Insomnia Scale Japanese version ≥6 or usage of sleeping pills in the previous year. Logistic regression was used to calculate odds ratio (OR) of insomnia related to Ne-Zake and Mukae-Zake adjusting for sex, age, presence of sleep-related disorders, frequency of alcohol consumption, and quantity of alcohol consumed per one occasion. RESULTS: We observed insomnia, Ne-Zake, and Mukae-Zake in 174 (23.3%), 140 (18.8%), and 37 (5.0%) participants, respectively. After adjustment for demographic and confounding factors, participants with Ne-Zake had a significantly higher prevalence of insomnia (OR 2.00 [95% confidence interval, 1.27-3.16]), compared to those without Ne-Zake. Mukae-Zake was also independently associated with a higher prevalence of insomnia among men (OR 3.26 [1.55-6.87]). Participants with both Ne-Zake and Mukae-Zake had a highly significant association with insomnia (OR 4.77 [2.01-11.3]) than those with neither Ne-Zake nor Mukae-Zake. Additionally, for insomnia, the association of Mukae-Zake was more pronounced than that of Ne-Zake (OR 4.09, 95% CI 1.14-14.7, p = 0.031; and OR 1.81, 95% CI 1.08-3.06, p = 0.026, respectively). CONCLUSION: Ne-Zake and Mukae-Zake were associated with insomnia independent of the quantity and frequency of alcohol consumption among Japanese farmers. This finding can be used for stratifying individuals with insomnia not only to improve sleep hygiene but also to prevent alcohol dependence by informing the general population that alcohol has a negative effect on sleep, contrary to popular beliefs.

    DOI: 10.1016/j.alcohol.2020.11.005

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  • Effect of Coronavirus Disease 2019 Pandemic on Physical Activity in a Rural Area of Japan: The Masuda Study. 査読

    Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Minako Kinuta, Noriko Nakahata, Hideyuki Kanda

    Journal of epidemiology   31 ( 3 )   237 - 238   2021年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.JE20200598

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  • Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines 査読

    Takashi Hisamatsu, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura

    Hypertension Research   43 ( 12 )   1344 - 1351   2020年12月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s41440-020-0508-z

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    その他リンク: http://www.nature.com/articles/s41440-020-0508-z

  • Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men. 査読 国際誌

    Mohammad Moniruzzaman, Aya Kadota, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Naoko Miyagawa, Akira Fujiyoshi, Takashi Hisamatsu, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Stroke   51 ( 12 )   3584 - 3591   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.

    DOI: 10.1161/STROKEAHA.120.030141

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  • Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years. 査読 国際誌

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    Journal of hypertension   38 ( 11 )   2230 - 2236   2020年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.

    DOI: 10.1097/HJH.0000000000002533

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  • Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. 査読 国際誌

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Sayuki Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Stroke   50 ( 10 )   2967 - 2969   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors. Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to <50%), or severe-ICAS (≥50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group. Results- The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors. Conclusions- In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.

    DOI: 10.1161/STROKEAHA.119.025964

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  • Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study 査読

    Hisamatsu T, Miura K, Fujiyoshi A, Kunimura A, Ito T, Miyazawa I, Torii S, Shiino A, Nozaki K, Kanda H, Arima H, Ohkubo T, Ueshima H, on behalf of, SESSA Research Group

    Eur J Neurol   26 ( 9 )   1219 - 1225   2019年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ene.13970

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ene.13970

  • Coronary artery calcium progression among the United States and Japanese men 査読

    Hisamatsu T, Liu K, Chan C, Krefman AE, Fujiyoshi A, Budoff MJ, Miura K, Lloyd-Jones DM, Ueshima H

    Circ Cardiovasc Imaging   12 ( 2 )   e008104   2019年

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    担当区分:筆頭著者, 責任著者  

    DOI: 10.1161/CIRCIMAGING.118.008104

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  • Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study 査読

    Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    International Journal of Cardiology   267   177 - 182   2018年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. Methods and results: We performed a prospective, population-based study of Japanese men aged 40–79 years without known coronary heart disease. We measured baseline serum irisin levels using an enzyme-linked immunosorbent assay and quantified coronary artery calcification (CAC) from serial computed tomography scans. Of 1038 participants (mean age, 63.9 years) at baseline, 670 (64.6%) had prevalent CAC. Of 810 participants at follow-up (median, 5.1 years), 407 (50.3%) experienced CAC progression. In Poisson regression with robust error variance adjusted for age and behavioral factors, serum irisin levels were inversely associated with CAC prevalence (relative risk [RR] of 4th versus 1st quartiles [95% confidence interval], 0.88 [0.78–0.99]
    trend P = 0.016) and CAC progression (RR, 0.76 [0.63–0.91]
    trend P = 0.002). After further adjustment for cardiometabolic risk factors, the inverse association with CAC prevalence disappeared (RR, 0.95 [0.84–1.08]
    trend P = 0.319), but that with CAC progression persisted (RR, 0.77 [0.64–0.93]
    trend P = 0.003). These associations were consistent when we applied ordinal logistic regression and across subgroups by cardiometabolic risk factor status. Conclusions: Higher serum irisin levels were associated with less burden of coronary atherosclerosis. This association would be mediated through and beyond traditional cardiometabolic pathways.

    DOI: 10.1016/j.ijcard.2018.05.075

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  • Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study 査読

    Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    Atherosclerosis   273   145 - 152   2018年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background and aims: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). Methods: We conducted a prospective study in a population-based sample of Japanese men aged 40–79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method. Results: Of 938 participants at baseline (mean age, 63.7 ± 9.9 years), AVC prevalence was observed in 173 (18.4%). Of 596 participants without baseline AVC at follow-up (median duration, 5.1 years), AVC incidence was observed in 138 (23.2%). After adjustment for demographics, behaviors and cardiovascular risk factors, relative risks (95% confidence intervals) in the highest versus lowest categories of serum magnesium, phosphorus, and calcium were 0.62 (0.44–0.86), 1.45 (1.02–2.04), and 1.43 (0.95–2.15), respectively, for AVC prevalence and 0.62 (0.42–0.92), 1.93 (1.28–2.91), and 1.09 (0.77–1.55), respectively, for AVC incidence. Their linear trends of serum magnesium and phosphorus were also all statistically significant. Of 131 participants with baseline AVC, there was no association of any serum micronutrients with AVC progression. Conclusions: Serum magnesium was inversely associated, while serum phosphorus was positively associated with AVC prevalence and incidence, suggesting that these serum micronutrients may be potential candidates for risk prediction or prevention of CAVD, and warranting further studies.

    DOI: 10.1016/j.atherosclerosis.2018.03.035

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  • Home Blood Pressure Variability and Subclinical Atherosclerosis in Multiple Vascular Beds: A Population-Based Study 査読

    Hisamatsu T, Miura K, Ohkubo T, Arima H, Fujiyoshi A, Satoh A, Kadota A, Zaid M, Takashima N, Ohno S, Horie M, Ueshima H

    J Hypertens   36 ( 11 )   2193 - 2203   2018年

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    担当区分:筆頭著者, 責任著者  

    DOI: 10.1097/HJH.0000000000001810

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  • Increased Aortic Calcification Is Associated With Arterial Stiffness Progression in Multiethnic Middle-Aged Men 査読

    Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Hypertension   69 ( 1 )   102 - 108   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association of aortic calcification burden with progression of arterial stiffness in population-based samples of healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort). Men (n=635) aged 40 to 49 years (207 white American, 45 black American, 142 Japanese American, and 241 Japanese in Japan) were examined at baseline and 4 to 7 years later. Aortic calcification was evaluated from level of aortic arch to iliac bifurcation. Arterial stiffness progression was measured as annual change in brachial-ankle pulse wave velocity. Multivariable-adjusted general linear models were applied to investigate associations of longitudinal change in aortic calcification with arterial stiffness progression in participants overall, as well as in subgroups without or with prevalent aortic calcification at baseline. Annual change in aortic calcification was positively and significantly associated with arterial stiffness progression. In participants with annual changes in aortic calcium score of 0, 1 to 10, 11 to 100, and &gt;100, the adjusted means (SD) for the annual change in brachial-ankle pulse wave velocity were 3.8 (2.2), 7.2 (2.2), 12.2 (1.8), and 15.6 (2.6) cm/s, respectively (P for trend &lt;0.01) adjusted for baseline aortic calcification, arterial stiffness, and standard cardiovascular risk factors. Arterial stiffness was associated with the incidence of aortic calcification over the follow-up period among participants without aortic calcification (n=297) and with an increase in aortic calcification among participants with prevalent aortic calcification at baseline (n=388). Our findings suggest aortic calcification may be causally linked to arterial stiffness.

    DOI: 10.1161/HYPERTENSIONAHA.116.08459

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  • Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men 査読

    Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Sayuki Torii, Sentaro Suzuki, Naoko Miyagawa, Atsushi Sato, Masahiro Yamazoe, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Yamamoto, Kiyoshi Murata, Robert D. Abbott, Akira Sekikawa, Minoru Horie, Hirotsugu Ueshima, Yasutaka Nakano, Emiko Ogawa, Hiroshi Maegawa, Itsuko Miyazawa, Kenichi Mitsunami, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Yasuyuki Nakamura, Tomonori Okamura, Emma J.M. Barinas‐Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Yoshitaka Murakami, Naoyuki Takashima, Takashi Kadowaki, Seiko Ohno, Keiko Kondo, Yoshino Saito, Maryam Zaid, Takahiro Ito, Takeshi Shibukawa, Masaki Sumi

    Journal of the American Heart Association   5 ( 9 )   2016年8月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1161/jaha.116.003738

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  • Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components 査読

    Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima

    Arteriosclerosis, Thrombosis, and Vascular Biology   36 ( 8 )   1703 - 1708   2016年8月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1161/atvbaha.116.307612

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  • Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population 査読

    Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

    Atherosclerosis   236 ( 2 )   237 - 243   2014年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.atherosclerosis.2014.07.019

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  • High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population 査読

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF CARDIOLOGY   64 ( 3-4 )   218 - 224   2014年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: Increased resting heart rate (RHR) independently predicts cardiovascular mortality. Meanwhile, long-chain n-3 fatty acids (LCn3FAs) have a cardioprotective effect. Our aim was to evaluate whether higher LCn3FAs intake attenuates the elevated risk of cardiovascular mortality associated with increased RHR.
    Methods: We conducted a population-based 24-year prospective cohort study of Japanese, whose LCn3FAs intake is relatively high. Study participants included 8807 individuals aged 30-95 years from randomly selected areas across Japan without cardiovascular diseases and anti-hypertensive drugs at baseline. The primary endpoint was cardiovascular mortality, and the secondary endpoints were cardiac and stroke mortality during 24 years of follow-up. Individual dietary LCn3FAs intake was estimated from household-based 3-day weighed food records. RHR was obtained from 3 consecutive R-wave intervals on 12-lead electrocardiography. Cox models were used to estimate the multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) adjusting for possible confounders.
    Results: During the follow-up period, 617 cardiovascular deaths were observed. The median daily intake of LCn3FAs was 0.37% kcal (0.86 g/day). The interaction between dietary LCn3FAs intake and RHR in the risk of cardiovascular mortality was statistically significant (p = 0.033). The risk of cardiovascular mortality was significantly higher in the low-intake group (&lt;0.37% kcal) with an RHR &gt;85 beats/min (bpm) [hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.15-2.43], but not in the high-intake group (&gt;= 0.37% kcal) with an RHR &gt;85 bpm (HR, 0.92; 95% CI, 0.61-1.38), compared with those in the high-intake group with an RHR &lt;70 bpm. Similar results were observed with stroke mortality, but not with cardiac mortality.
    Conclusions: The risk of cardiovascular mortality associated with increased RHR is elevated in participants with low dietary LCn3FAs intake, but not in participants with high dietary LCn3FAs intake in a representative Japanese general population. These results suggest that high dietary LCn3FAs intake may prevent cardiovascular mortality associated with increased RHR. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jjcc.2014.01.005

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  • Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men 査読

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    Heart   99 ( 14 )   1024 - 1029   2013年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    Objective Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) &gt;= 0.1 mV on electrocardiography.
    Design A prospective population-based cohort study.
    Setting The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan.
    Participants A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan.
    Main outcome measures Cardiac death (200 men) during the 24-year follow-up.
    Results Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35% kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (&lt;0.35% kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p&lt;0.001), but not in the high intake group (&gt;= 0.35% kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006).
    Conclusions The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.

    DOI: 10.1136/heartjnl-2012-303496

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  • Association between J-Point elevation and death from coronary artery disease 査読

    Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, for the NIPPON DATA, Research Group

    Circ J.   77 ( 5 )   1260 - 1266   2013年

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    担当区分:筆頭著者, 責任著者  

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  • Prologue: Special Spotlight Issue on Japan. 国際誌

    Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario

    Journal of human hypertension   2021年8月

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  • Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men. 査読

    Thien Vu, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Maryam Zaid, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Yoshihisa Nakagawa, Tomoaki Suzuki, Tohru Asai, Katsuyuki Miura, Hirotsugu Ueshima

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 7 )   1076 - 1082   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. CONCLUSIONS: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.

    DOI: 10.1253/circj.CJ-20-1090

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  • Apolipoprotein A2 Isoforms: New Insight into the Risk of Myocardial Infarction 査読

    Takashi Hisamatsu

    Journal of Atherosclerosis and Thrombosis   28 ( 5 )   469 - 470   2021年5月

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    担当区分:筆頭著者, 最終著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    DOI: 10.5551/jat.ed150

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  • Epidemiology and control of hypertension in Japan: a comparison with Western countries. 査読 国際誌

    Takashi Hisamatsu, Katsuyuki Miura

    Journal of human hypertension   2021年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Based on data from national surveys, the prevalence of hypertension rests at 40-60% in Japan, the USA, and in European countries. This suggests there has been little progress in the prevention of hypertension in even high-income countries despite their well-functioning health systems. In particular, compared with the USA and European countries, the improvement in awareness, treatment, and control of hypertension has been relatively low in Japan. For example, the rates of hypertension awareness, treatment, and control were observed, respectively, in 60-70%, 50-60%, and 20-30% of Japanese compared with 80-90%, 70-80%, and 50-60% of US citizens in the years around 2015. The lower proportions in Japan might be explained by the slower progress in lowering the accepted thresholds for diagnosis of hypertension and initiation of treatment compared with Western countries; however, the underlying reasons for the differences warrant further study. The high prevalence (>40%) of uncontrolled hypertension in even high-income countries has major implications for the prevention of cardiovascular disease. Health policy and research on early control of high blood pressure at the individual and public health levels will contribute to decreases in the prevalence of hypertension. Furthermore, proactive treatment and strict adherence to intensified antihypertensive treatment guidelines will more effectively achieve targeted blood pressure levels. In this context, it is important to continue to carefully monitor and compare trends in hypertension across countries.

    DOI: 10.1038/s41371-021-00534-3

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  • A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium. 査読

    Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. METHODS: Japanese men aged 40-79y (n=869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCAmean), internal carotid artery (ICAmean) and bifurcation (Bifmean). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. RESULTS: All cIMT measures had positive associations with CAC (p<0.001): [OR, 95% Confidence Interval]: ICAmean [1.23, 1.07-1.42], CCAmean [1.27, 1.08-1.49], Bifmean [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile (p<0.05), while CCAmean had some of the weakest associations among age quartiles. CONCLUSIONS: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCAmean, was no longer associated with coronary calcium after age-adjustment and stratification.

    DOI: 10.5551/jat.61283

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  • Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men. 査読

    Ebtehal Salman, Aya Kadota, Takashi Hisamatsu, Hiroyoshi Segawa, Sayuki Torii, Akira Fujiyoshi, Keiko Kondo, Yoshiyuki Watanabe, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura, For The Sessa Research Group

    Journal of atherosclerosis and thrombosis   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    AIM: The relationship of blood pressure (BP) indexes (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], mean arterial pressure [MAP]) to subclinical cerebrovascular diseases (SCVDs) remains unclear. This study aimed to elucidate the relationship of four BP indexes measured at two visits on SCVDs assessed by magnetic resonance imaging (MRI) in general Japanese men. METHODS: In general Japanese men aged 40-79 years (N=616), office BP indexes were measured at two visits (Visits 1 [2006-2008] and 2 [2010-2014]). MRI images obtained on the third visit (2012-2015) were examined for prevalent SCVDs: lacunar infarction, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), microbleeds, and intracranial artery stenosis (ICAS). Using a multivariable logistic regression analysis, we computed and estimated the odds ratio of each prevalent SCVD for one standard deviation higher BP indexes. The same analyses were performed using home BP. RESULTS: All four office BP indexes at both visits associated with lacunar infarction. Visit 1 and 2 DBP and Visit 1 MAP associated with PVH and DSWMH, and Visit 1 SBP associated with DSWMH. All Visit 2 BP indexes appear to show stronger association with microbleeds than Visit 1 indexes, and Visit 1 and 2 SBP, PP, and MAP showed similar associations with ICAS. Additional analyses using home BP indexes revealed similar relationships; however, the significance of some relationships decreased. CONCLUSION: In general Japanese men, BP indexes were associated with most of SCVDs, and BP indexes measured at different periods associated with different SCVDs assessed by MRI.

    DOI: 10.5551/jat.58537

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  • Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study. 査読 国際誌

    Mohammad Moniruzzaman, Aya Kadota, Akihiko Shiino, Akira Fujiyoshi, Takahiro Ito, Ali Haidar Syaifullah, Naoko Miyagawa, Keiko Kondo, Takashi Hisamatsu, Hiroyoshi Segawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of physical activity & health   18 ( 2 )   157 - 164   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Kinetics  

    BACKGROUND: To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. METHODS: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). RESULTS: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). CONCLUSIONS: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.

    DOI: 10.1123/jpah.2019-0659

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    その他リンク: https://journals.humankinetics.com/downloadpdf/journals/jpah/aop/article-10.1123-jpah.2019-0659/article-10.1123-jpah.2019-0659.xml

  • Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men. 査読 国際誌

    Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 1 )   80 - 87   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40-79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

    DOI: 10.1038/s41440-020-00533-w

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    その他リンク: http://www.nature.com/articles/s41440-020-00533-w

  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS). 査読 国際誌

    Kei Asayama, Yasuharu Tabara, Emi Oishi, Satoko Sakata, Takashi Hisamatsu, Kayo Godai, Mai Kabayama, Yukako Tatsumi, Jun Hata, Masahiro Kikuya, Kei Kamide, Katsuyuki Miura, Toshiharu Ninomiya, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension   43 ( 12 )   1403 - 1412   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Despite the clinical usefulness of self-measured home blood pressure (BP), reports on the characteristics of home BP have not been sufficient and have varied due to the measurement conditions in each study. We constructed a database on self-measured home BP, which included five Japanese general populations as subdivided aggregate data that were clustered and meta-analyzed according to sex, age category, and antihypertensive drug treatment at baseline (treated and untreated). The self-measured home BPs were collected after a few minutes of rest in a sitting position: (1) the morning home BP was measured within 1 h of waking, after urination, before breakfast, and before taking antihypertensive medication (if any); and (2) the evening home BP was measured just before going to bed. The pulse rate was simultaneously measured. Eligible data from 2000 onward were obtained. The morning BP was significantly higher in treated participants than in untreated people of the same age category, and the BP difference was more marked in women. Among untreated residents, home systolic/diastolic BPs measured in the morning were higher than those measured in the evening; the differences were 5.7/5.0 mmHg in women (ranges across the cohorts, 5.3-6.8/4.7-5.4 mmHg) and 7.3/7.7 mmHg in men (ranges, 6.4-8.5/7.0-8.7 mmHg). In contrast, the home pulse rate in women and men was 2.4 (range, 1.5-3.7) and 5.6 (range, 4.6-6.6) beats per minute, respectively, higher in the evening than in the morning. We demonstrated the current status of home BP and home pulse rate in relation to sex, age, and antihypertensive treatment status in the Japanese general population. The approach by which fine-clustered aggregate statistics were collected and integrated could address practical issues raised in epidemiological research settings.

    DOI: 10.1038/s41440-020-0530-1

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    その他リンク: http://www.nature.com/articles/s41440-020-0530-1

  • The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. 査読 国際誌

    Aya Hirata, Akemi Kakino, Tomonori Okamura, Yoko Usami, Yoshiko Fujita, Aya Kadota, Akira Fujiyoshi, Takashi Hisamatsu, Keiko Kondo, Hiroyoshi Segawa, Tatsuya Sawamura, Katsuyuki Miura, Hirotsugu Ueshima

    Atherosclerosis   313   20 - 25   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    BACKGROUND AND AIMS: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). METHODS: We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). RESULTS: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively. CONCLUSIONS: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.

    DOI: 10.1016/j.atherosclerosis.2020.09.013

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  • Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey. 査読 国際誌

    Toshiki Sanoh, Eri Eguchi, Tetsuya Ohira, Fumikazu Hayashi, Masaharu Maeda, Seiji Yasumura, Yuriko Suzuki, Hirooki Yabe, Atsushi Takahashi, Kanae Takase, Mayumi Harigane, Takashi Hisamatsu, Keiki Ogino, Hideyuki Kanda, Kenji Kamiya

    International journal of environmental research and public health   17 ( 21 )   7832 - 7832   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Evidence regarding the effect of psychological factors and evacuation on cardiovascular disease occurrence after large-scale disasters is limited. This prospective study followed up a total of 37,810 Japanese men and women aged 30-89 years from the Fukushima Prefecture with no history of stroke or heart disease at baseline (2012), until 2017. This period included 3000 cardiovascular events recorded through questionnaires and death certificates. The participants' psychological distress, trauma reaction, and evacuation status were defined, and divided into four groups based on combinations of psychological factors and evacuation status. We calculated the hazard ratios and 95% confidence intervals for only psychological, only evacuation, or both of them compared with neither using Cox proportional hazard models. Psychological factors along with evacuation resulted in approximately 5% to 25% higher magnitude of stroke and heart disease risk than psychological factors only among men. Compared to neither, the multivariable hazard ratios of those with both psychological distress and evacuation were 1.75 for stroke and 1.49 for heart disease, and those of both trauma reaction and evacuation were 2.01 and 1.57, respectively, among men. Evacuation combined with psychological factors increased the risk of stroke and heart disease risks especially in men after the Great East Japan Earthquake.

    DOI: 10.3390/ijerph17217832

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  • The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study. 査読

    Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   27 ( 9 )   995 - 1009   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    AIM: Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs in a healthy Japanese male population. METHODS: In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. CAC was scored using the Agatston method. The following SCVDs were assessed using magnetic resonance imaging: intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds. The participants were categorized according to CAC scores as follows: no CAC (0), mild CAC (1-100), and moderate-to-severe CAC (>100). The adjusted odds ratios of prevalent SCVDs were computed in reference to the no-CAC group using logistic regression. RESULTS: The mean (standard deviation) age of the participants was 68 (8.4) years. Participants in the moderate-to-severe CAC category showed significantly higher odds of prevalent lacunar infarction, DSWMH, and ICAS in age-adjusted and risk-factor-adjusted models. Microbleeds and PVH, in contrast, did not show any significant associations. The trends for CAC with lacunar infarction, DSWMH, and ICAS were also significant (all P-values for trend ≤ 0.02). CONCLUSIONS: Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels.

    DOI: 10.5551/jat.51284

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  • Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1. 査読 国際誌

    Hideki Itoh, Takashi Hisamatsu, Takuhisa Tamura, Kazuhiko Segawa, Toshiaki Takahashi, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Shugo Suwazono, Shingo Sasaki, Ken Okumura, Minoru Horie, Masanori P Takahashi, Tsuyoshi Matumura

    Journal of the American Heart Association   9 ( 17 )   e015709   2020年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow-up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow-up period of 87 months (Q1-Q3, 37-138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22-15.50) were associated with sudden death. In contrast, PQ interval ≥240 ms, QRS duration ≥120 ms, nutrition, or respiratory failure were not associated with the incidence of sudden death. The multivariable analysis revealed that a PQ interval ≥240 ms (HR, 2.79; 95% CI, 1.9-7.19, P<0.05) or QRS duration ≥120 ms (HR, 9.41; 95% CI, 2.62-33.77, P < 0.01) were independent factors associated with a higher occurrence of cardiac events than those observed with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. Conclusions Cardiac conduction disorders are independent markers associated with cardiac events. Further investigation on the prediction of occurrence of sudden death is warranted.

    DOI: 10.1161/JAHA.119.015709

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  • Smoking habits and progression of coronary and aortic artery calcification: A 5-year follow-up of community-dwelling Japanese men 査読

    Tai Pham, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Ayako Kunimura, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    International Journal of Cardiology   314   89 - 94   2020年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ijcard.2020.05.016

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  • Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. 査読

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Sayuki Torii, Naoyuki Takashima, Ikuo Tooyama, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 6 )   244 - 252   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    BACKGROUND: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. METHODS: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score, with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. RESULTS: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend = 0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend = 0.015) in mutual-adjustment model. CONCLUSIONS: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.

    DOI: 10.2188/jea.JE20180258

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  • Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study. 査読

    Ziyi Liu, Maryam Zaid, Takashi Hisamatsu, Sachiko Tanaka, Akira Fujiyoshi, Naoko Miyagawa, Takahiro Ito, Aya Kadota, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 3 )   121 - 127   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.

    DOI: 10.2188/jea.JE20180193

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  • Physical activity levels in American and Japanese men from the ERA-JUMP Study and associations with metabolic syndrome. 査読 国際誌

    Naoko Sagawa, Bonny Rockette-Wagner, Koichiro Azuma, Hirotsugu Ueshima, Takashi Hisamatsu, Tomoko Takamiya, Aiman El-Saed, Katsuyuki Miura, Andrea Kriska, Akira Sekikawa

    Journal of sport and health science   9 ( 2 )   170 - 178   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    Background: Metabolic syndrome (MetS) is a global health problem. Physical activity (PA) is a known modifiable risk factor for MetS and individual MetS components. However, the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors. To examine these differences, multi-country studies with standardized outcome measurement methods across cohorts are needed. Methods: Cross-sectional PA levels (total and domain specific) in healthy middle-aged (44-56 years) men in the Risk Factor Assessment among Japanese and U.S. Men in the Post-World War II Birth Cohort (ERA-JUMP) Study (n = 730; American: n = 417; Japanese: n = 313; from population-representative samples in Pittsburgh, Pennsylvania, USA, and Kusatsu, Shiga, Japan) were compared. The relationships between PA levels and MetS (overall and specific components) in/across the American and Japanese sub-cohorts (adjusting for age, smoking, and alcohol consumption) were also assessed using the same instruments (pedometer and validated questionnaire) to measure PA in both cohorts. Results: A total of 510 individuals provided complete data on PA (American: n = 265; Japanese: n = 245). The American cohort had significantly lower mean ± SD steps/day (7878 ± 3399 steps/day) vs. the Japanese cohort (9055 ± 3797 steps/day) (p < 0.001) but had significantly higher self-reported moderate-vigorous leisure PA (American: 15.9 (7.4-30.3) metabolic task equivalent hours per week (MET-h/week) vs. Japanese: 4.0 (0-11.3) MET-h/week, p < 0.0001). In both sub-cohorts, each 1000 steps/day increase was associated with lower odds of having MetS (American: OR = 0.90, 95%CI: 0.83-0.98; Japanese: OR = 0.87, 95%CI: 0.79-0.95) and the individual MetS component of high waist circumference (American: OR = 0.86, 95%CI: 0.79-0.94; Japanese: OR = 0.87, 95%CI: 0.80-0.95). In the American cohort only, higher self-reported leisure PA (Met-h/week) was associated with lower odds of MetS and high waist circumference (OR = 0.98, 95%CI: 0.97-0.99 for MetS and waist circumference, respectively). Conclusion: Higher total step counts/day had an important protective effect on MetS prevalence in both the Japanese and American cohorts, despite differences in PA levels and other MetS risk factors. The effect of steps/day (across all intensity levels) was much greater than domain-specific moderate-vigorous PA captured by questionnaire, suggesting the need for measurement tools that can best capture total movement when examining the effects of PA on MetS development.

    DOI: 10.1016/j.jshs.2019.09.007

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  • Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis). 査読 国際誌

    Keiko Fuse, Aya Kadota, Keiko Kondo, Katsutaro Morino, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Itsuko Miyazawa, Satoshi Ugi, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

    Diabetes research and clinical practice   160   108002 - 108002   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM. METHODS: In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models. RESULTS: Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2. CONCLUSIONS: Liver fat accumulation assessed by CT was associated with the incidence of DM.

    DOI: 10.1016/j.diabres.2020.108002

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  • Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men. 査読

    Yuyan Liu, Akira Fujiyoshi, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Itsuko Miyazawa, Keiko Kondo, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   26 ( 12 )   1102 - 1114   2019年12月

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    記述言語:英語  

    AIM: Computed tomography (CT) can directly provide information on body compositions and distributions, compared to anthropometric indices. It has been shown that various obesity indices are associated with carotid intima-media thickness (IMT). However, whether CT-based obesity indices are stronger than anthropometric indices in association with atherosclerosis remains to be determined in a general population. METHODS: We cross-sectionally assessed carotid IMT using ultrasound in 944 community-dwelling Japanese men free of stroke and myocardial infarction. CT image at the L4-L5 level was obtained to compute areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Anthropometric measures assessed included body mass index (BMI), waist circumference, and waist-to-hip ratio. Using multivariable linear regression, slopes of IMT per 20th to 80th percentile of each index were compared. We also compared the slope of index with simultaneous adjustment for BMI in the same model. RESULTS: Areas of VAT and SAT were positively associated with IMT, but not stronger than those of anthropometric indices in point estimates. Among all obesity indices, BMI was strongest in association with IMT after adjusting for age and lifestyle factors or further adjusting for metabolic factors. In simultaneous adjustment models, BMI, but not CT-based indices, remained significant and showed the strongest association. CONCLUSIONS: In community-dwelling Japanese men, anthropometric obesity indices, BMI in particular, were more strongly associated with carotid atherosclerosis than CT-based obesity indices. The association of general obesity with carotid atherosclerosis was strong and adding CT-based obesity measure did not considerably influence in the association.

    DOI: 10.5551/jat.47977

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  • Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men 査読 国際誌

    Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Open Heart   6 ( 2 )   e001119 - e001119   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ  

    <sec><title>Objective</title>This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese).

    </sec><sec><title>Methods</title>In a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD).

    </sec><sec><title>Results</title>The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=−2% to 3%).

    </sec><sec><title>Conclusions</title>Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.

    </sec>

    DOI: 10.1136/openhrt-2019-001119

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連 SESSA 査読

    宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣

    肥満研究   25 ( Suppl. )   250 - 250   2019年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本肥満学会  

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  • 現代の我が国の一般地域住民における家庭血圧の現状 Modern Database on Ambulatory and Self-measured home blood pressure(MDAS) 査読

    浅山 敬, 田原 康玄, 大石 絵美, 坂田 智子, 久松 隆史, 呉代 華容, 樺山 舞, 辰巳 友佳子, 秦 淳, 菊谷 昌浩, 神出 計, 三浦 克之, 二宮 利治, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集   42回   293 - 293   2019年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(NPO)日本高血圧学会  

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80 査読

    久松 隆史, 三浦 克之, 大久保 孝義, 門田 文, 近藤 慶子, 喜多 義邦, 早川 岳人, 神田 秀幸, 岡村 智教, 岡山 明, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   42回   302 - 302   2019年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(NPO)日本高血圧学会  

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  • The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. 査読 国際誌

    Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of hypertension   37 ( 8 )   1676 - 1681   2019年8月

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    記述言語:英語  

    OBJECTIVE: We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men. METHODS: We analyzed the data of 919 Japanese male participants who were randomly selected from general population (mean age 64.5 years). OBP was measured twice consecutively by a trained nurse using electrical device after 5 min of complete rest alone in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during 7 consecutive days. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score at least 10. We calculated odds ratios for the presence of CAC per one SD higher OBP and HBP adjusted for age and other cardiovascular risk factors. RESULTS: The mean systolic OBP (SD) and HBP (SD) were 136.8 (19.0) and 137.2 (18.5) mmHg, respectively, without statistical difference between the two (P = 0.595). OBP and HBP were highly correlated (r = 0.74 P < 0.001). CAC was found in 454 (49.4%) participants. Multivariable-adjusted odds ratios [95% confidence interval (CI)] for the presence of CAC were comparable between OBP (1.32, 95% CI: 1.12-1.56) and HBP (1.35, 95% CI: 1.14-1.60) (P heterogeneity = 0.813). CONCLUSION: The strength of association of accurately measured OBP with CAC was comparable with that of HBP among randomly selected male general population aged 40-79 years.

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, for the NIPPON DATA, Research Group

    Journal of atherosclerosis and thrombosis   26 ( 8 )   746 - 746   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.ER17244

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  • Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

    Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   29 ( 6 )   205 - 212   2019年6月

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    記述言語:英語  

    BACKGROUND: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. METHODS: From 2006-2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1-160.9, 161-321.9, 322-482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. RESULTS: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. CONCLUSIONS: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

    DOI: 10.2188/jea.JE20170191

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  • 一般日本人女性における受動喫煙状態と血管内皮機能との関連(Association of Passive Smoking Status to Endothelial Vascular Function among General Japanese Women) 査読

    門田 文, 近藤 慶子, 久松 隆史, 宮澤 伊都子, 藤吉 朗, 上島 弘嗣, 三浦 克之

    日本循環器学会学術集会抄録集   83回   PJ041 - 4   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本循環器学会  

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  • Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men. 査読 国際誌

    Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Open heart   6 ( 2 )   e001119   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective: This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese). Methods: In a population-based study of 570 randomly selected asymptomatic men aged 40-49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD). Results: The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=-2% to 3%). Conclusions: Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.

    DOI: 10.1136/openhrt-2019-001119

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  • Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men 査読

    Sekikawa A, Mahajan H, Kadowaki S, Hisamatsu T, Miyagawa N, Fujiyoshi A, Kadota A, Maegawa H, Murata K, Miura K, Edmundowicz D, Ueshima H

    Eur J Clin Nutr   75 ( 5 )   783 - 792   2019年

  • Differences between Coronary Artery Calcification and Aortic Artery Calcification in relation to Cardiovascular Disease Risk Factors in Japanese Men 査読

    Kimani C, Kadota A, Miura K, Fujiyoshi A, Zaid M, Kadowaki S, Hisamatsu T, Arima H, Horie M, Ueshima H, for the SESSA Research Group

    J Atheroscler Thromb   26 ( 5 )   452 - 464   2019年

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  • Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea 査読

    Hisamatsu T

    Korean Circ J   49   e108   2019年

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    担当区分:筆頭著者, 責任著者  

    DOI: 10.4070/kcj.2019.0197

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  • Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea 査読

    Abhishek Vishnu, Jina Choo, Aya Kadota, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Dorothy Leann Long, Takashi Hisamatsu, Vasudha Ahuja, Yasuyuki Nakamura, Rhobert W. Evans, Katsuyuki Miura, Kamal H. Masaki, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    International Journal of Cardiology   266   245 - 249   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. Methods: We conducted a population-based study among apparently healthy middle-aged men aged 40–49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. Results: Whites (22.8%) had more than four-fold higher prevalence (p &lt
    0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors – incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. Conclusion: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.

    DOI: 10.1016/j.ijcard.2018.03.010

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  • Corrigendum to "Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population." [Atherosclerosis 246 (March 2016) 141-147]. 査読

    Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, ACCESS, SESSA Research Groups

    Atherosclerosis   278   336   2018年8月

  • Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

    Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   25 ( 6 )   477 - 489   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization. We examined an independent relationship between each risk factor used in prediction models and CAC score ≥100 by logistic regression. We then divided the participants into quintiles of estimated CHD risk per prediction model to calculate odds ratio of having CAC score ≥100. Receiver operating characteristic curve and c-index were used to examine discriminative ability of prevalent CAC for each prediction model. RESULTS: Age, smoking status, and systolic blood pressure were significantly associated with CAC score ≥100 in the multivariable analysis. The odds of having CAC score ≥100 were higher for those in higher quintiles in all prediction models (p-values for trend across quintiles <0.0001 for all models). All prediction models showed fair and similar discriminative abilities to detect CAC score ≥100, with similar c-statistics (around 0.70). CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population.

    DOI: 10.5551/jat.42416

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  • Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study. 査読

    Mahajan H, Choo J, Masaki K, Fujiyoshi A, Guo J, Hisamatsu T, Evans R, Shangguan S, Willcox B, Okamura T, Vishnu A, Barinas-Mitchell E, Ahuja V, Miura K, Kuller L, Shin C, Ueshima H, Sekikawa A

    Data in brief   17   1091 - 1098   2018年4月

  • QT延長症候群1型の変異特異的リスク層別化における課題(A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1) 査読 国際誌

    八木 典章, 伊藤 英樹, 久松 隆史, 大野 聖子, 堀江 稔

    日本循環器学会学術集会抄録集   82回 ( 1 )   PJ046 - 3   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    BACKGROUND: The relationship between mutation locations in KCNQ1 which is a major gene in long QT syndrome (LQTS) and phenotype has been analyzed and used for risk stratification. Mutations in the transmembrane region (TM) or cytoplasmic-loop (C-loop) are associated with more frequent cardiac events than those in other regions. However, accumulation of LQTS type 1 (LQT1) patients poses the question of whether the location specific risk stratification is really effective. METHODS: The study cohort consisted of 67 KCNQ1 mutation carriers and 13 family members who were suspected as having LQTS due to sudden cardiac death or syncope from 36 unrelated families. The KCNQ1 mutations were L250H, V254M, H258P, and R259C located in segment 4-5 linker (C-loop), G269S, and S277L in segment 5 (TM). RESULTS: More than half of the patients with V254M or S277L suffered sudden cardiac death or syncope. In contrast, those with other mutations showed mild phenotype. In these two mutations related to severe phenotype, gender frequency and the age of onset were contrasting, 14 out of 23 patients with V254M were male, 19 out of 22 patients with S277L were female. In the patients we could confirm the age of onset, all of the patients with V254M showed symptoms at less than 15 years old, while 5 out of 12 patients with S277L suffered symptoms after 16 years old. CONCLUSION: Clinical characteristics were not specific for mutation locations but specific for respective mutations in our LQT1 patients. Patients should be evaluated by their own mutations to prevent severe cardiac events.

    DOI: 10.1016/j.jjcc.2017.12.011

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  • Association of alcohol consumption and aortic calcification in healthy men aged 40–49 years for the ERA JUMP Study 査読

    Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Takashi Hisamatsu, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Tomonori Okamura, Abhishek Vishnu, Emma Barinas-Mitchell, Vasudha Ahuja, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    Atherosclerosis   268   84 - 91   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background and aims Several studies have reported a significant inverse association of light to moderate alcohol consumption with coronary heart disease (CHD). However, studies assessing the relationship between alcohol consumption and atherosclerosis have reported inconsistent results. The current study was conducted to determine the relationship between alcohol consumption and aortic calcification. Methods We addressed the research question using data from the population-based ERA-JUMP Study, comprising of 1006 healthy men aged 40–49 years, without clinical cardiovascular diseases, from four race/ethnicities: 301 Whites, 103 African American, 292 Japanese American, and 310 Japanese in Japan. Aortic calcification was assessed by electron-beam computed tomography and quantified using the Agatston method. Alcohol consumption was categorized into four groups: 0 (non-drinkers), ≤1 (light drinkers), &gt
    1 to ≤3 (moderate drinkers) and &gt
    3 drinks per day (heavy drinkers) (1 drink = 12.5 g of ethanol). Tobit conditional regression and ordinal logistic regression were used to investigate the association of alcohol consumption with aortic calcification after adjusting for cardiovascular risk factors and potential confounders. Results The study participants consisted of 25.6% nondrinkers, 35.3% light drinkers, 23.5% moderate drinkers, and 15.6% heavy drinkers. Heavy drinkers [Tobit ratio (95% CI) = 2.34 (1.10, 4.97)
    odds ratio (95% CI) = 1.67 (1.11, 2.52)] had significantly higher expected aortic calcification score compared to nondrinkers, after adjusting for socio-demographic and confounding variables. There was no significant interaction between alcohol consumption and race/ethnicity on aortic calcification. Conclusions Our findings suggest that heavy alcohol consumption may be an independent risk factor for atherosclerosis.

    DOI: 10.1016/j.atherosclerosis.2017.11.017

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  • Self-reported sleep duration and subclinical atherosclerosis in a general population of japanese men 査読

    Sentaro Suzuki, Hisatomi Arima, Soichiro Miyazaki, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Takashi Hisamatsu, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Minoru Horie, Kiyoshi Murata, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   25 ( 2 )   186 - 198   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    Aim: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men. Methods: This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire
    CAC by computed tomography
    and carotid IMT by ultrasonography. Results: The prevalence of CAC was 50.0% for participants with sleep duration<5.5 h, 43.9% with 5.5 – 6.4 h, 50.0% with 6.5 –7.4 h, 49.3% with 7.5–8.4 h, and 62.5% with ≥8.5 h. In univariate analysis, participants with sleep duration ≥8.5 h had significantly higher prevalence of CAC than those with 6.5–7.4 h (p=0.043). After adjustment for age and other risk factors, however, the association was not significant (p=0.776). The average IMT was 0.85 mm for participants with sleep duration<5.5 h, 0.83 mm with 5.5–6.4 h, 0.85 mm with 6.5–7.4 h, 0.88 mm with 7.5–8.4 h, and 0.90 mm with ≥ 8.5 h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p>0.1). Conclusion: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men.

    DOI: 10.5551/jat.40527

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  • Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) 査読

    Seto-Yukimura R, Ogawa E, Hisamatsu T, Torii S, Shiino A, Nozaki K, Fujiyoshi A, Miura K, Nakano Y, Ueshima H, SESSA Research Group

    J Atheroscler Thromb   25 ( 10 )   1009 - 1021   2018年

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  • Associations between changes in pericardial fat volume and cardiovascular risk factors in a general population of Japanese men 査読

    Miyazawa I, Ohkubo T, Kadowaki S, Fujiyoshi A, Hisamatsu T, Kadota A, Arima H, Budoff M, Murata K, Miura K, Maegawa H, Ueshima H

    Circ J   82 ( 10 )   2542 - 2548   2018年

  • Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men 査読

    Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa

    BRITISH JOURNAL OF NUTRITION   117 ( 2 )   260 - 266   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CAMBRIDGE UNIV PRESS  

    Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol &gt;83 nm. The presence of CAC was defined as a coronary Ca score 10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 5127 (interquartile range (IQR) 1941, 11700), 91 (IQR 010, 331) and 00 (IQR 00, 10) nm, respectively. Prevalence of CAC and equol-producers was 96 and 160 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 010 (95 % CI 001, 090, P&lt;004). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.

    DOI: 10.1017/S000711451600458X

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  • The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men 査読

    Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Abhisek Vishnu, Aya Kadota, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Rhobert W. Evans, Bradley J. Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

    JOURNAL OF HYPERTENSION   35 ( 1 )   111 - 117   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: A few studies have examined the longitudinal association of blood pressure (BP) with arterial stiffness progression, and the results were inconsistent. The objective of this study was to investigate the roles of initial BP and its longitudinal change on the progression of arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV).
    Method: Study participants (n = 656) were from population-based samples of healthy men aged 40-49 years at baseline (213 White Americans, 47 AfricanAmericans, 152 Japanese Americans and 244 Japanese in Japan). BP measures, baPWV and other factors were examined at baseline and 4-7 years later. General linear regression was applied for statistical analyses.
    Result: Annual change in SBP (standardized coefficient: 0.33, P&lt;0.001), but not its baseline level (standardized coefficient: 0.03, P = 0.495), had a positive significant association with the progression of baPWV after adjusting for a wide range of standard cardiovascular risk factors. Similarly, annual changes in DBP (standardized coefficient: 0.35, P&lt;0.001), pulse pressure (standardized coefficient: 0.15, P = 0.001) and mean arterial pressure (standardized coefficient: 0.37, P&lt;0.001) were positively associated with the progression of baPWV. None of the baseline measures were related to the progression of baPWV.
    Conclusion: Our findings imply that, regardless of initial BP, effective monitoring and controlling of BP is important to slow down arterial wall stiffening and hence reduce cardiovascular risk.

    DOI: 10.1097/HJH.0000000000001144

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  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA) 査読

    久松隆史, 久松隆史, 三浦克之, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 柳田昌彦, 前川聡, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017年

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    担当区分:筆頭著者, 責任著者  

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  • Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読 国際誌

    Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Koichiro Azuma, Sachiko Tanaka, Takashi Hisamatsu, Hisatomi Arima, Aya Kadota, Naoko Miyagawa, Naoyuki Takashima, Takayoshi Ohkubo, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima

    Preventive medicine reports   4   225 - 32   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40-64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m(2) (median, 23.5 kg/m(2)). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001-0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009-0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated.

    DOI: 10.1016/j.pmedr.2016.06.013

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  • Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers 査読

    Yasuharu Tabara, Hirotsugu Ueshima, Naoyuki Takashima, Takashi Hisamatsu, Akira Fujiyoshi, Maryam Zaid, Masaki Sumi, Katsuhiko Kohara, Tetsuro Miki, Katsuyuki Miura

    ATHEROSCLEROSIS   254   242 - 248   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background and aims: While alcohol consumption is known to increase plasma high-density lipoprotein (HDL) cholesterol levels, its relationship with low-density lipoprotein (LDL) cholesterol levels is unclear. Aldehyde dehydrogenase 2 (ALDH2) is a rate-controlling enzyme in alcohol metabolism, but a large number of Japanese people have the inactive allele. Here, we conducted a Mendelian randomization analysis using the ALDH2 genotype to clarify a causal role of alcohol on circulating cholesterol levels and lipoprotein particle numbers.
    Methods: This study was conducted in three independent general Japanese populations (men, n = 2289; women, n = 1940; mean age 63.3 +/- 11.2 years). Alcohol consumption was assessed using a questionnaire. Lipoprotein particle numbers were determined by nuclear magnetic resonance spectroscopy.
    Results: Alcohol consumption increased linearly in proportion to the number of subjects carrying the enzymatically active *1 allele in men (p &lt; 0.001). The *1 allele was also positively associated with HDL cholesterol level (adjusted mean +/- standard error, *1*1: 60 +/- 0.5, *1*2: 56 +/- 0.6, *2*2: 55 +/- 1.3 mg/dl, p &lt; 0.001) and inversely associated with LDL cholesterol level (116 +/- 0.9, 124 +/- 1.1, 130 +/- 2.6 mg/dl, p &lt; 0.001). The *1 allele was also positively associated with HDL particle numbers (per-allele: 2.60 +/- 0.32 mmol/l, p &lt; 0.001) and inversely associated with LDL particle numbers (-67.8 +/- 19.6 nmol/l, p = 0.001). Additional Mendelian randomization analysis failed to clarify the involvement of cholesteryl ester transfer protein in alcohol-related changes in lipoprotein cholesterol levels. No significant association was observed in women, presumably due to their small amount of alcohol intake.
    Conclusions: Alcohol consumption has a causal role in not only increasing HDL cholesterol levels but also decreasing LDL cholesterol levels and particle numbers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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  • Early repolarization and risk of arrhythmia events in long QT syndrome 査読

    Kanae Hasegawa, Hiroshi Watanabe, Takashi Hisamatsu, Seiko Ohno, Hideki Itoh, Takashi Ashihara, Hideki Hayashi, Takeru Makiyama, Tohru Minamino, Minoru Horie

    INTERNATIONAL JOURNAL OF CARDIOLOGY   223   540 - 542   2016年11月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.ijcard.2016.08.215

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  • Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification 査読

    Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D. Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 5 )   1195 - 1202   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).
    OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDLC, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.
    METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; &gt;0 Agatston score) were examined.
    RESULTS: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.
    CONCLUSIONS: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P. (C) 2016 National Lipid Association. All rights reserved.

    DOI: 10.1016/j.jacl.2015.12.027

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  • Lipoprotein-associated phospholipase A(2) is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population 査読

    Hirotsugu Ueshima, Takashi Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Akira Sekikawa, Aya Kadota, Sayaka Kadowaki, Yasuyuki Nakamura, Naoko Miyagawa, Tomonori Okamura, Yoshikuni Kita, Naoyuki Takashima, Atsunori Kashiwagi, Hiroshi Maegawa, Minoru Horie, Takashi Yamamoto, Takeshi Kimura, Toru Kita

    ATHEROSCLEROSIS   246   141 - 147   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL). Lp-PLA2 is recognized as playing a key role in inflammatory processes and the development of atherosclerosis. This study aimed to investigate whether Lp-PLA2 is related to subclinical atherosclerosis, independently from traditional risk factors, in a general Japanese population by analyses of both the observational study and Mendelian randomization using V279F polymorphism.
    Methods and results: We cross-sectionally examined community-based sample of 929 Japanese men aged 40-79 years, without statin treatment, who were randomly selected from the resident registration. Multiple regression analyses of Lp-PLA2 activity and concentration were undertaken separately for men aged 40-49 years and 50-79 years, to clarify interactions of age and Lp-PLA2. Lp-PLA2 activity for men aged 50-79 years was significantly and positively related to intima-media thickness (IMT) (P = 0.013) and plaque index (P = 0.008) independent of traditional risk factors including small LDL particles, but not to coronary artery calcification (CAC) score. Associations with Lp-PLA2 concentration were qualitatively similar to those of activity. Corresponding relationships were not observed in men aged 40e49 years. Mendelian randomization analyses based on V279F genotype did not show any significant associations with subclinical atherosclerosis, although the homozygote and heterozygote of V279F showed low LpPLA2 activity and concentration.
    Conclusions: Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that LpPLA2 is a causative factor for subclinical atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  • Pediatric Cohort With Long QT Syndrome-KCNH2 Mutation Carriers Present Late Onset But Severe Symptoms - 査読

    Junichi Ozawa, Seiko Ohno, Takashi Hisamatsu, Hideki Itoh, Takeru Makiyama, Hiroshi Suzuki, Akihiko Saitoh, Minoru Horie

    CIRCULATION JOURNAL   80 ( 3 )   696 - 702   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background: In children with long QT syndrome (LQTS), risk factors for cardiac events have been reported, but age-, gender-and genotype-related differences in prognosis remain unknown in Asian countries.
    Methods and Results: The study examined clinical prognosis at age between 1 and 20 years in 496 LQTS patients who were genotyped as either of LQT1-3 (male, n=206). Heterozygous mutations were observed in 3 major responsible genes: KCNQ1 in 271, KCNH2 in 192, and SCN5A in 33 patients. LQTS-associated events were classified into 3 categories: (1) syncope (n=133); (2) repetitive torsade de pointes (TdP, n=3); and (3) cardiopulmonary arrest (CPA, n=4). The risk of cardiac events was significantly lower in LQT1 girls than boys &lt;= 12 years (HR, 0.55), whereas LQT2 female patients &gt;= 13 years had the higher risk of cardiac events than male patients (HR, 4.60). Patients in the repetitive TdP or CPA group included 1 LQT1 female patient, 1 LQT2 male patient, and 5 LQT2 female patients. All LQT2 patients in these groups had TdP repeatedly immediately after the antecedent event. In addition, all 5 female LQT2 patients in these groups had the event after or near puberty.
    Conclusions: Female LQT2 children might have repeated TdP shortly after prior events, especially after puberty.

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  • Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese 査読

    Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 1 )   172 - 180   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations.
    METHODS: A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody.
    RESULTS: Serum LAB levels (median [interquartile range], mu g cs/L) were 5341 mu g cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 mu m) compared with the first quartile (797 mu m) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC &gt;= 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 mu m (12.7), 856 mu m (16.7) in the low LAB/hypercholesterolemia group, and 833 mu m (8.4) in the low LAB/normal cholesterol group (P = .004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication.
    CONCLUSION: Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia. (C) 2016 National Lipid Association. All rights reserved.

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  • High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia 査読

    Keiko Sonoda, Hiroshi Watanabe, Takashi Hisamatsu, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Minoru Horie, Tohru Minamino

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   21 ( 1 )   30 - 40   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    BackgroundJ wave, or early repolarization has recently been associated with an increased risk of lethal arrhythmia and sudden death, both in idiopathic ventricular fibrillation and in the general population. Hypercalcemia is one of the causes of J point and ST segment elevation, but the relationship has not been well studied. The aim of this study was to examine the effects of hypercalcemia on J point elevation.
    MethodsElectrocardiographic findings were compared in 89 patients with hypercalcemia and 267 age- and sex-matched healthy controls with normocalcemia. The association of J point elevation with arrhythmia events in patients with hypercalcemia was also studied.
    ResultsThe PR interval and the QRS duration were longer in patients with hypercalcemia than in normocalcemic controls. Both the QT and the corrected QT intervals were shorter in patients with hypercalcemia compared with normocalcemic controls. Conduction disorders, ST-T abnormalities, and J point elevation were more common in patients with hypercalcemia than normocalcemic controls. Following the resolution of hypercalcemia, the frequency of J point elevation decreased to a level similar to that noted in controls. During hospitalization, no arrhythmia event occurred in patients with hypercalcemia.
    ConclusionHypercalcemia was associated with J point elevation.

    DOI: 10.1111/anec.12303

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  • Association between pulse wave velocity and coronary artery calcification in Japanese men the shiga epidemiological study of subclinical atherosclerosis (SESSA 査読

    Sayuki Torii, Hisatomi Arima, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saito, Naoko Miyagawa, Maryam Zaid, Yoshitaka Murakami, Robert D. Abbott, Minoru Horie, Katsuyuki Miura, SESSA Research Group, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   22 ( 12 )   1266 - 1277   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    Aim: Pulse wave velocity (PWV is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC is an intermediate stage in the process leading to overt cardiovascular disease (CVD and an established determinant of coro nary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. Methods: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC. Results: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles <1378, 1378-1563, 1564-1849, and >1849 cm/s (P< 0.001 for trend. Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P= 0.042 for trend. The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. Conclusions: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.

    DOI: 10.5551/jat.30247

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  • Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men 査読

    Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J. M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY   189   67 - 72   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men.
    Methods: A population-based sample of 1131men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as &gt;= 10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV.
    Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p &lt; 0.01), or by 36% per standard-deviation increase (p &lt; 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans.
    Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacks in the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  • High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men 査読

    Maryam Zaid, SESSA Research group, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Emiko Ogawa, Itsuko Miyazawa, Kiyoshi Murata, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Emma Barinas-Mitchell, Daniel Edmundowicz, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Takashi Kadowaki, Sayaka Kadowaki, Yoshitaka Murakami, Seiko Ohno

    Atherosclerosis   239 ( 2 )   444 - 450   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P&lt
    0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

    DOI: 10.1016/j.atherosclerosis.2015.01.031

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  • Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study 査読

    S. R. El Khoudary, C. Shin, K. Masaki, K. Miura, M. Budoff, D. Edmundowicz, S. Kadowaki, E. Barinas-Mitchell, A. El-Saed, A. Fujiyoshi, R. W. Evans, T. Hisamatsu, T. Ohkubo, B. J. Willcox, L. H. Kuller, H. Ueshima, A. Sekikawa

    INTERNATIONAL JOURNAL OF OBESITY   39 ( 3 )   488 - 494   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    BACKGROUND/OBJECTIVES: Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.
    SUBJECTS/METHODS: Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).
    RESULTS: Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values &lt; 0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value &lt; 0.05).
    CONCLUSIONS: Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.

    DOI: 10.1038/ijo.2014.154

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  • Comparison of HOMA-IR, HOMA-β%, and disposition index between U.S. Caucasian men and Japanese men in Japan: the ERA JUMP study 査読

    Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell E, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashiwagi A, Kuller LH, Ueshima H, Sekikawa A, for the ERA JUMP, Study Group

    Diabetologia   58 ( 2 )   265 - 271   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00125-014-3414-6

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  • Long-term outcomes associated with prolonged PR interval in the general Japanese population 査読

    Takashi Hisamatsu, NIPPON DATA80 Research Group, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-Ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Fumiyoshi Kasagi, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshitaka Murakami, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara

    International Journal of Cardiology   184 ( 1 )   291 - 293   2015年

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:Elsevier Ireland Ltd  

    DOI: 10.1016/j.ijcard.2015.02.028

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  • Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study 査読

    Shin-ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   22 ( 6 )   590 - 598   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ATHEROSCLEROSIS SOC  

    Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians.
    Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models.
    Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all &lt; 0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC.
    Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.

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  • Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis 査読

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Kadowaki, Sayaka Kadowaki, Maryam Zaid, Takashi Hisamatsu, Akira Sekikawa, Matthew J. Budoff, Kiang Liu, Hirotsugu Ueshima

    AMERICAN JOURNAL OF EPIDEMIOLOGY   180 ( 6 )   590 - 598   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    The incidence of coronary heart disease in the United States has declined, and prevalences of several coronary disease risk factors have become comparable to those in Japan. Therefore, the burden of coronary atherosclerosis may be closer among younger persons in the 2 countries. We aimed to compare prevalences of coronary atherosclerosis, measured with coronary artery calcium scores, between men in the 2 countries by age group (45-54, 55-64, or 65-74 years). We used community-based samples of Caucasian men in the United States (2000-2002; n = 1,067) and Japanese men in Japan (2006-2008; n = 832) aged 45-74 years, stratifying them into groups with 0, 1, 2, or &gt;= 3 of the following risk factors: current smoking, overweight, diabetes, dyslipidemia, and hypertension. We calculated adjusted odds ratios of US Caucasian men's having Agatston scores of &gt;= 10, &gt;= 100, and &gt;= 400 with reference to Japanese men. Overall, the odds of Caucasian men having each Agatston cutoff point were greater. The ethnic difference, however, became smaller in younger age groups. For example, adjusted odds ratios for Caucasian men's having an Agatston score of &gt;= 100 were 2.05, 2.43, and 3.86 among those aged 45-54, 55-64, and 65-74 years, respectively. Caucasian men in the United States had a higher burden of coronary atherosclerosis than Japanese men, but the ethnic difference was smaller in younger age groups.

    DOI: 10.1093/aje/kwu169

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  • Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80 査読

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    ATHEROSCLEROSIS   232 ( 2 )   384 - 389   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake.
    Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population.
    Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake.
    Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37% kcal (0.86 g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P = 0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline).
    Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.atherosclerosis.2013.11.073

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  • Long-chain n-3 Polyunsaturated Fatty Acids Intake and Cardiovascular Disease Mortality Risk in a General Japanese Population: NIPPON DATA80 査読

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    STROKE   44 ( 2 )   2013年2月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • Is More Aggressive Prevention of Coronary Artery Disease Required for Patients With Early Repolarization Syndrome? (Letter) 査読

    Hisamatsu T, Ohkubo T, Miura K, Horie M, Ueshima H

    Circ J   77 ( 6 )   1643   2013年

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    担当区分:筆頭著者, 責任著者  

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H

    J Atheroscler Thromb.?   20 ( 10 )   755 - 766   2013年

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  • Long-term risk of BP values above normal for cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years 査読

    Takashima N, Ohkubo T, Miura K, Okamura T, Murakami Y, Fujiyoshi A, Nagasawa SY, Kadota A, Kita Y, Miyagawa N, Hisamatsu T, Hayakawa T, Okayama A, Ueshima H

    J Hypertens   30 ( 12 )   2209 - 2306   2012年

  • ループス腎炎に対する免疫抑制剤加療中に出現した尿蛋白量の減少にACE阻害薬(イミダプリル)が奏効した一例 査読

    下垣保恵, 筒井崇, 大平直人, 久松隆史, 田中雅博, 望月裕司, 豊田嘉清, 中井直治, 竹内孝男, 郡山健治, 河野厚

    臨床リウマチ   22 ( 4 )   389 - 393   2010年

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書籍等出版物

  • 心疾患の動向.循環器病予防エビデンスブック

    久松隆史( 担当: 単著 ,  範囲: 心疾患の動向)

    医歯薬出版  2021年 

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  • 健康教育マニュアル第2版, 血圧測定法の種類と血圧分類(分担),高血圧薬物治療の原則(分担)

    ( 担当: 共著)

    日本家族計画協会  2019年 

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  • Tobacco and Cardiovascular Disease. Vasan R and Sawyer D (Edit.). Encyclopedia of Cardiovascular Research and Medicine

    Kanda H, Hisamatsu T( 範囲: 537-544)

    Elsevier  2017年 

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  • 健康教育マニュアル, 血圧測定法の種類と血圧分類(分担),高血圧薬物治療の原則(分担),

    久松隆史( 担当: 共著 ,  範囲: 128-132, 150-153)

    日本家族計画協会  2014年 

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MISC

  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連:滋賀動脈硬化疫学研究

    久松隆史, 大久保孝義, 藤吉朗, 鳥居さゆ希, 瀬川裕佳, 近藤慶子, 門田文, 高嶋直敬, 設楽智史, 有馬久富, 中川義久, 渡邉嘉之, 椎野顯彦, 野崎和彦, 野崎和彦, 上島弘嗣, 上島弘嗣, 三浦克之, 三浦克之

    日本疫学会学術総会講演集(Web)   31st ( Suppl. )   89 - 89   2021年

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 【最新の高血圧診療:「高血圧治療ガイドライン2019」後の展開】高血圧の成因、分類、疫学 高血圧の疫学

    久松 隆史, 三浦 克之

    診断と治療   108 ( 4 )   445 - 451   2020年4月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <Headline>1 国民の収縮期血圧平均値は、男女ともいずれの年齢階級においても過去約60年で大きく低下した一方、拡張期血圧平均値は、特に60歳未満の男性では低下傾向が明らかではない。2 高血圧有病率は依然高く、50歳以上の男性、60歳以上の女性ではおおよそ60%以上である状態が続いている。3 高血圧管理率は改善傾向にあるものの、男性では約40%、女性では約45%にとどまっており、現在のところ降圧薬内服者の半数以上は管理不十分である。4 2017年の高血圧者の推計数は計4,300万人、うち3,100万人(72%)が管理不良であった。5 日本国民の血圧水準、高血圧有病率、および高血圧管理率をさらに改善させるには、高血圧者に対するハイリスクアプローチと、国民全体でのポピュレーションアプローチを組み合わせた総合的な対策の積極的な推進が重要である。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00697&link_issn=&doc_id=20200422190004&doc_link_id=%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 【高血圧診療update-診断・治療の最新動向-】わが国の高血圧の疫学

    久松 隆史, 三浦 克之

    日本臨床   78 ( 2 )   204 - 209   2020年2月

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    記述言語:日本語   出版者・発行元:(株)日本臨床社  

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  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率:益田研究

    久松隆史, 福田茉莉, 谷口かおり, 宮川健, 中畑典子, 神田秀幸

    日本公衆衛生学会総会抄録集   79th   339 - 339   2020年

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田茉莉, 中畑典子, 神田秀幸, 神田秀幸

    日本疫学会学術総会講演集(Web)   30th   2020年

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松 隆史, 三浦 克之, 大久保 孝義, 門田 文, 近藤 慶子, 喜多 義邦, 早川 岳人, 神田 秀幸, 岡村 智教, 岡山 明, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   42回   302 - 302   2019年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 循環器疾患を予防する リスク因子の集積・メタボリックシンドロームと循環器疾患

    久松隆史

    公衆衛生   83 ( 5 )   350 - 355   2019年

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    <文献概要>はじめに 循環器疾患の古典的なリスク因子である肥満,高血圧,糖尿病,脂質異常症が合併しやすいことは以前から知られていた.現在では,腹部肥満,特に内臓脂肪型肥満(インスリン抵抗性)を基盤として,血圧上昇,血糖高値,脂質異常が集積した病態が「メタボリックシンドローム」(metabolic syndrome)と定義されている.肥満が原因となって,先述のリスク因子が軽度でも集積して存在すると循環器疾患リスクが高くなることが知られており,メタボリックシンドロームは循環器疾患の一次予防において重要な概念となっている.わが国では,欧米諸国と比較して肥満者割合が依然として低い一方で,肥満を伴わないリスク因子保有・集積者における循環器疾患リスクがメタボリックシンドローム有所見者のそれと同等か,それよりも高いことが報告されるなど,非肥満者におけるリスク因子保有・集積の重要性が認識されている.本稿は,リスク因子の集積に焦点を当て,わが国の疫学研究成果を踏まえて循環器疾患への影響を検討する.さらに,循環器疾患一次予防に関する包括的なリスク評価と,公衆衛生上の対策について概説する.

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00447&link_issn=&doc_id=20190507110008&doc_link_id=10.11477%2Fmf.1401209138&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1401209138&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Coronary artery calcium: Its clinical utility in primary prevention

    Hisamatsu T, Fujiyoshi A, Miura K

    Clin Calcium   29 ( 2 )   215 - 223   2019年

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  • (循環器病予防総説シリーズ 6:記述疫学編 2)わが国における心疾患の死亡率・罹患率の動向 査読

    久松隆史, 久松隆史, 久松隆史, 三浦克之, 三浦克之

    日本循環器病予防学会誌   53 ( 1 )   1 - 8   2018年

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    日本における衛生統計・地域の疫学調査成績や国際比較を通じて、心疾患の中でも死亡率が高く疫学的知見の豊富な冠動脈疾患を中心に、その危険因子も含めて時代的な推移を概説した。心疾患全体での粗死亡率が上昇している一方、急性心筋梗塞を含む冠動脈疾患の粗死亡率は必ずしも上昇していない。また、冠動脈疾患を年齢調整死亡率で比較すると、日本は依然男女とも世界の中で最低水準と考えられた。一方で、急性心筋梗塞罹患率の都市部、男性における増加傾向が一部の疫学研究から示されており、その死亡率も近い将来上昇傾向に転じる可能性が懸念された。

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  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連 地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    久松 隆史, 三浦 克之, 渋川 武志, 藤吉 朗, 有馬 久富, 門田 文, 宮川 尚子, 鳥居 さゆ希, 近藤 慶子, 宮澤 伊都子, 鈴木 仙太朗, 佐藤 敦, 山添 正博, 柳田 昌彦, 前川 聡, 上島 弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017年3月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    【背景】客観的に評価された身体活動量がメタボリックシンドローム(MetS)発症リスクと関連するかどうか検討した研究はほとんどない。【目的】日本人一般住民男性において、歩数計を用いて評価された歩数値とMetS新規発症との関連を縦断的に検討すること。【方法】滋賀県草津市住民から無作為抽出された40-79歳男性のうちMetSを有さない525名(平均年齢64.1±9.6歳)を対象とし、5年間の前向きコホート研究(基礎調査2006-8年)を実施した。歩数は基礎調査時に土・日曜日を含む7日間連続で歩数計を用いて測定し1日平均値を求めた。MetS発症の診断は日本基準を用いて評価した。ロジスティック回帰を用いてMetS新規発症に対する歩数値に関する多変量調整相対リスク(RR)および95%信頼区間(CI)を算出した。【結果】平均追跡期間4.8±1.3年を経て、MetS新規発症者は77名(14.7%)であった。Body mass indexを含む交絡因子を調整後も歩数値とMetS発症との間に負の関連を認めた。この関連はMetS各構成要素でさらに調整しても変わらなかった(最低三分位群[5,792歩未満]と比較して、最高三分位群[10,033歩以上]のMetS発症に対するRR(95%CI)は0.34[0.17-0.72])。また、MetS発症に対する1日平均1,000歩増加あたりのRR(95%CI)は、0.87(0.78-0.96)であった。65歳未満・以上、MetS各構成要素の有無で層別に解析したが同様の傾向を認めた(全異質性P値>0.3)。【結語】MetSの好発集団とされる一般中高年男性において、客観的に評価された歩数値はMetS発症と有意な負の関連を示した。また、1日平均歩数値1,000歩増加あたりMetS発症リスクが13%低下した。本成果は健康日本21(第二次)の歩数目標値や身体活動基準2013を支持する結果である。(著者抄録)

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  • 動脈・静脈疾患の疫学 血管疾患の疫学-国際比較-

    久松隆史, 三浦克之

    日本臨床   75 ( 増刊4 動脈・静脈の疾患(上) )   43 - 50   2017年

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    記述言語:日本語   出版者・発行元:(株)日本臨床社  

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  • Coronary artery calcification for prevention of atherosclerotic cardiovascular disease

    Hisamatsu T

    Shimane J Med Sci   34 ( 1 )   1 - 5   2017年

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    久松隆史

    上原記念生命科学財団研究報告集(CD-ROM)   31   1 - 6   2017年

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    記述言語:日本語   出版者・発行元:(公財)上原記念生命科学財団  

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  • 潜在性動脈硬化症の疫学 5)喫煙の潜在性動脈硬化への影響

    久松隆史

    動脈硬化予防   16 ( 3 )   32 - 36   2017年

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    喫煙は動脈硬化性心血管病(atherosclerotic cardiovascular disease;ASCVD)に対する最大の予防可能な危険因子である。ASCVD発症前の一般健常集団において、喫煙習慣(現在喫煙・禁煙)、特に現在喫煙は、冠動脈・頸動脈・大動脈・末梢動脈を含む全身の潜在性動脈硬化の進展と強固に関連し、これらの進展は生涯喫煙量(pack-year)の多い喫煙者・禁煙者ほど大きく、一方、早期に禁煙した禁煙者ほど生涯非喫煙者に近づくものと考えられる。欧米諸国と比較して依然喫煙率が高いわが国におけるASCVDのさらなる予防のためには、防煙ならびに喫煙者における早期の禁煙の積極的な推進が重要である。(著者抄録)

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   117   2016年1月

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  • 冠動脈疾患と降圧療法 冠動脈疾患と高血圧(疫学)

    久松隆史, 三浦克之

    血圧   23 ( 7 )   460 - 465   2016年

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    記述言語:日本語   出版者・発行元:(株)先端医学社  

    高血圧は、冠動脈疾患を含む心血管病の代表的な危険因子であり、日常診療で最もよく遭遇する疾患である。人口の急速な高齢化や生活習慣の欧米化の進展に伴い、都市部を中心とした冠動脈疾患発症率の増加および、とくに男性における高血圧有病率の上昇が今後懸念され、またアジア人では冠動脈疾患に対する高血圧の寄与度は大きいことから、わが国における冠動脈疾患予防に関して、高血圧対策が重要であると再認識する必要がある。至適血圧を超えて血圧が高くなるほど冠動脈疾患の死亡・発症リスクは高くなり、わが国における冠動脈疾患死亡の50%以上が至適血圧を超える血圧高値に起因するものと推定される。ポピュレーションアプローチを用いて国民全体の収縮期血圧平均値を4mmHg低下させることにより、冠動脈疾患死亡数が年間約5千人減少すると推計される。(著者抄録)

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  • 身近に考えよう 循環器内科の素朴な疑問 検査 1):心電図 Question02 健康診断で心電図異常を認めた際,どのような所見がある場合に専門医に依頼すべきでしょうか?たとえば,期外収縮でも紹介すべきですか?脚ブロックやR波増高不良,Brugada型心電図などで悩むことが多くあります.

    久松隆史

    治療   98 ( 3 )   333 - 336   2016年

  • 心電図におけるJ-point上昇と生命予後の関係

    久松 隆史, 三浦 克之

    日本医事新報   ( 4750 )   58 - 59   2015年5月

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  • 潜在性動脈硬化の規定要因:ERA JUMP,SESSAより

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   47th   119 - 119   2015年

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  • 高血圧の疫学から学ぶ公衆衛生の役割と展望

    久松隆史, 三浦克之

    Heart View   19 ( 4 )   25 - 33   2015年

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  • 危険因子 Lp-PLA2

    久松隆史, 久松隆史, 上島弘嗣, 三浦克之, 三浦克之

    動脈硬化予防   14 ( 1 )   113 - 118   2015年

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  • 高血圧治療ガイドラインJSH2014改訂と高血圧治療の展望 4 高血圧の疫学から学ぶ公衆衛生の役割と展望

    久松隆史, 三浦克之, 久松隆史, 三浦克之

    Heart View   19 ( 4 )   361 - 369   2015年

  • 我が国におけるHDLコレステロール値の推移とその関連要因の疫学的検討:NIPPON DATA・循環器疾患基礎調査を用いた統合データ解析,1990-2010年

    久松隆史, 尾島俊之, 中村保幸, 清原裕, 中川秀昭, 桑原和代, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本循環器病予防学会誌   50 ( 2 )   142 - 142   2015年

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  • 高血圧診療のup to date 高血圧の疫学

    久松隆史, 三浦克之

    月刊臨床と研究   91 ( 1 )   1 - 8   2014年

  • 高血圧治療ガイドラインJSH2014 2)疫学

    久松隆史, 三浦克之

    動脈硬化予防   13 ( 3 )   11 - 17   2014年

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  • 疫学 脳卒中疫学の国際比較

    久松隆史, 大久保孝義, 三浦克之

    日本臨床   72 ( 増刊5 最新臨床脳卒中学(上) )   44 - 51   2014年

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  • 【多リスク時代の新しいストラテジー トータル血管マネージメント】日本人の脳卒中、心筋梗塞、腎臓病に対するリスク因子の寄与度の違い わが国の疫学研究から

    久松 隆史, 大久保 孝義, 堀江 稔, 三浦 克之

    Mebio   27 ( 10 )   30 - 44   2010年10月

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ

    日本腎臓学会誌   63 ( 4 )   478 - 478   2021年6月

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  • Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men(和訳中)

    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   84回   OJ25 - 5   2020年7月

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  • 最新の高血圧診療:「高血圧治療ガイドライン2019」後の展開 高血圧の成因,分類,疫学 高血圧の疫学

    久松隆史, 三浦克之

    診断と治療   108 ( 4 )   445 - 451   2020年

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <Headline>1 国民の収縮期血圧平均値は、男女ともいずれの年齢階級においても過去約60年で大きく低下した一方、拡張期血圧平均値は、特に60歳未満の男性では低下傾向が明らかではない。2 高血圧有病率は依然高く、50歳以上の男性、60歳以上の女性ではおおよそ60%以上である状態が続いている。3 高血圧管理率は改善傾向にあるものの、男性では約40%、女性では約45%にとどまっており、現在のところ降圧薬内服者の半数以上は管理不十分である。4 2017年の高血圧者の推計数は計4,300万人、うち3,100万人(72%)が管理不良であった。5 日本国民の血圧水準、高血圧有病率、および高血圧管理率をさらに改善させるには、高血圧者に対するハイリスクアプローチと、国民全体でのポピュレーションアプローチを組み合わせた総合的な対策の積極的な推進が重要である。(著者抄録)

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  • 山陰地方の中学・高校教職員におけるインターネット利用状況の実態

    神田秀幸, 福田茉莉, 土江梨奈, 津村秀樹, 久松隆史

    産業衛生学雑誌   62 ( 2 )   108 - 108   2020年

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  • 全国高校eスポーツ選手権大会出場校の実態

    神田秀幸, 田邉莉奈, 福田茉莉, 久松隆史

    日本アルコール・薬物医学会雑誌   55 ( 5 )   90 - 90   2020年

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  • 「健康診査・保健指導における健診項目等の必要性,妥当性の検証,及び地域における健診実施体制の検討のための研究」8.コホート研究での実証:滋賀動脈硬化疫学研究(SESSA)における上下肢血圧比(ABI,Ankle Brachial Index)/脈波伝播速度(PWV,Pulse Wave Velocity)と冠動脈石灰化との関連

    三浦克之, 久松隆史, 藤吉朗, 門田文, 上島弘嗣

    健康診査・保健指導における健診項目等の必要性、妥当性の検証、及び地域における健診実施体制の検討のための研究 令和元年度 総括・分担研究報告書(Web)   2020年

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  • 日本の中学・高校教員におけるインターネット依存と頸部痛のリスクの関連

    田邉莉奈, 久松隆史, 福田茉莉, 土江梨奈, 鈴木雅子, 菅谷渚, 中村幸志, 高橋謙造, 神田秀幸

    日本アルコール・薬物医学会雑誌   55 ( 5 )   95 - 95   2020年

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連 SESSA

    宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣

    肥満研究   25 ( Suppl. )   250 - 250   2019年10月

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  • 現代の我が国の一般地域住民における家庭血圧の現状 Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山 敬, 田原 康玄, 大石 絵美, 坂田 智子, 久松 隆史, 呉代 華容, 樺山 舞, 辰巳 友佳子, 秦 淳, 菊谷 昌浩, 神出 計, 三浦 克之, 二宮 利治, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集   42回   293 - 293   2019年10月

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  • 一般日本人女性における受動喫煙状態と血管内皮機能との関連(Association of Passive Smoking Status to Endothelial Vascular Function among General Japanese Women)

    門田 文, 近藤 慶子, 久松 隆史, 宮澤 伊都子, 藤吉 朗, 上島 弘嗣, 三浦 克之

    日本循環器学会学術集会抄録集   83回   PJ041 - 4   2019年3月

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連:SESSA

    宮澤伊都子, 大久保孝義, 村上陽子, 永谷幸裕, 佐藤滋高, 藤吉朗, 藤吉朗, 久松隆史, 門田文, 門脇紗也佳, 瀬川裕佳, 近藤慶子, 新田哲久, 前川聡, 三浦克之, 三浦克之, 上島弘嗣

    日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集   40th-37th ( Suppl. )   250 - 250   2019年

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松隆史, 久松隆史, 三浦克之, 大久保孝義, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 喜多義邦, 早川岳人, 早川岳人, 神田秀幸, 神田秀幸, 岡村智教, 岡村智教, 岡山明, 岡山明, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   302 - 302   2019年

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  • 現代の我が国の一般地域住民における家庭血圧の現状:Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山敬, 田原康玄, 大石絵美, 坂田智子, 久松隆史, 呉代華容, 樺山舞, 辰巳友佳子, 秦淳, 菊谷昌浩, 神出計, 三浦克之, 二宮利治, 大久保孝義

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   293 - 293   2019年

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  • IoTを活用した長期家庭血圧管理研究の実践報告と課題【益田研究:第1報】

    福田茉莉, 中畑典子, 宮川健, 谷口かおり, 久松隆史, 神田秀幸

    日本公衆衛生学会総会抄録集   78th   330 - 330   2019年

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  • 家庭血圧測定実施者における食習慣と食物摂取状況の変化【益田研究:第2報】

    中畑典子, 福田茉莉, 宮川健, 谷口かおり, 久松隆史, 神田秀幸

    日本公衆衛生学会総会抄録集   78th   330 - 330   2019年

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  • 動脈硬化とカルシウム~カルシウムパラドックスの謎に迫る~一次予防における冠動脈石灰化の意義

    久松隆史, 藤吉朗, 藤吉朗, 三浦克之, 三浦克之

    Clinical Calcium   29 ( 2 )   215 - 223   2019年

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    記述言語:日本語   出版者・発行元:(株)医薬ジャーナル社  

    <文献概要>潜在性動脈硬化指標の一つとして,単純CTにより定量的に評価された冠動脈石灰化がある。一次予防において,危険因子への長期曝露の結果である冠動脈石灰化所見を用いることで,有効に動脈硬化性心血管病の発症を予測し,中等度リスク保有者の管理において治療方針の決定などリスクの層別化を行い得る可能性が検討されている。また,冠動脈石灰化は動脈硬化進展マーカーとしても用いられる。一方,冠動脈石灰化測定の費用対効果や放射線被曝の問題などでは確定的な結論が得られていない。一次予防における冠動脈石灰化の有用性の確立のために,わが国を含む冠動脈石灰化に関する研究の更なる発展およびエビデンスの集積が望まれる。

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02593&link_issn=&doc_id=20190204290010&doc_link_id=10.20837%2F4201902215&url=https%3A%2F%2Fdoi.org%2F10.20837%2F4201902215&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 NIPPON DATA2010実行ワーキンググループ報告

    大久保孝義, 宮本恵宏, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 大澤正樹, 東山綾, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 平成30年度 総括・分担研究報告書(Web)   2019年

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  • 勤労者における測定環境室温と家庭血圧値の変動に関する横断研究-益田研究より-

    神田秀幸, 福田茉莉, 中畑典子, 宮川健, 谷口かおり, 久松隆史

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   375 - 375   2019年

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  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下 SESSA研究

    宮川 尚子, 大久保 孝義, 藤吉 朗, 斎藤 祥乃, 久松 隆史, 門田 文, 関川 暁, 三浦 克之, 上島 弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018年5月

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  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤 慶子, 有馬 久富, 岡見 雪子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 森野 勝太郎, 前川 聡, 三浦 克之, 上島 弘嗣, 滋賀動脈硬化疫学研究(SESSA)グループ

    糖尿病   61 ( Suppl.1 )   S - 157   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究

    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ

    糖尿病   61 ( Suppl.1 )   S - 293   2018年4月

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population 査読

    Miyagawa Naoko, Arima Hisatomi, Yoshita Katsushi, Okuda Nagako, Ohkubo Takayoshi, Hisamatsu Takashi, Kondo Keiko, Miura Katsuyuki

    CIRCULATION   137   2018年3月

  • Objectively Measured Step Counts Was Independently Associated With Higher Cognition in Apparently Healthy Japanese Men 査読

    Shibukawa Takeshi, Fujiyoshi Akira, Miura Katsuyuki, Miyagawa Naoko, Saito Yoshino, Zaid Maryam, Hisamatsu Takashi, Ohkubo Takayoshi, Arima Hisatomi, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   137   2018年3月

  • 日本人男性の一般集団における腸内微生物叢と冠動脈石灰化 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Gut Microbiota and Coronary Artery Calcification in a General Population of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))

    有馬 久富, 近藤 慶子, 岡見 雪子, 藤 吉朗, 門田 文, 高嶋 直敬, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ12 - 6   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 日本人一般集団における血清N-3 polyunsaturated fatty acidと高感度C反応性蛋白の関連性(Association of Serum N-3 Polyunsaturated Fatty Acids and High-sensitivity C-reactive Protein in Japanese General Population)

    中村 翼, 門田 文, 近藤 慶子, 宮川 尚子, 関川 暁, 藤 吉朗, 久松 隆史, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ24 - 7   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • The Association Between Coronary Artery Calcium And Cerebral Small Vessel Disease: A Population Based Cross Sectional Study 査読

    Khan Md, Maruf Haque, Fujiyoshi Akira, Miura Katsuyuki, Hisamatsu Takashi, Torii Sayuki, Suzuki Sentaro, Shiino Akihiko, Nozaki Kazuhiko, Ohkubo Takayoshi, Ueshima Hirotsugu

    STROKE   49   2018年1月

  • 日本人一般住民男性における腸内細菌と血清LDLコレステロールとの関連:SESSA研究

    岡見雪子, 有馬久富, 近藤慶子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   178 - 178   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下:SESSA研究

    宮川尚子, 大久保孝義, 藤吉朗, 斎藤祥乃, 久松隆史, 門田文, 関川暁, 三浦克之, 上島弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • 一般住民男性における無症候性頭蓋内血管性病変と認知機能との関連:滋賀動脈硬化疫学研究SESSA

    伊藤隆洋, 藤吉朗, 大久保孝義, 椎野顕彦, 野崎和彦, 宮川尚子, 鳥居さゆ希, 久松隆史, 三浦克之, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   189 - 189   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 地域住民一般男性における筋肉面積,脂肪筋面積と年齢や体格との関連の検討:SESSA/ERA-JUMP横断研究

    藤吉朗, 門脇紗也佳, 東宏一郎, 門田文, 門田文, 近藤慶子, 久松隆史, 国村彩子, 関川暁, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   199 - 199   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 イベント判定委員会報告(ND2010イベント判定委員会)

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 門田文, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)   2018年

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連:滋賀動脈硬化疫学研究

    布施恵子, 布施恵子, 門田文, 門田文, 近藤慶子, 藤吉朗, 久松隆史, 久松隆史, 門脇紗也佳, 宮澤伊都子, 森野勝太郎, 関根理, 卯木智, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤慶子, 有馬久富, 岡見雪子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 森野勝太郎, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連 滋賀動脈硬化疫学研究SESSA

    久松 隆史, 三浦 克之, 有馬 久富, 門田 文, 門脇 紗也佳, 鳥居 さゆ希, 鈴木 仙太朗, 宮川 尚子, 佐藤 敦, 藤吉 朗, 大久保 孝義, アボット・ロバート, 関川 暁, 堀江 稔, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   49回   112 - 112   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study 査読

    Fujiyoshi Akira, Ohkubo Takayoshi, Miura Katsuyuki, Shiino Akihiko, Miyagawa Naoko, Takashima Naoyuki, Saitoh Yoshino, Torii Sayuki, Kadota Aya, Kadowaki Sayaka, Hisamatsu Takashi, Miyazawa Itsuko, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   135   2017年3月

  • Risk Factors for the Progression and Incidence of Aortic Calcification in an International Multi-ethnic Cohort of Men Aged 40-49 Years: ERA JUMP Study

    Siyi Shangguan, Jingchuan Guo, Hemant Mahajan, Kamal Masaki, Bradly J. Willcox, Katsuyuki Miura, Hirotsugu Ueshima, Akira Fujiyoshi, Takashi Hisamatsu, Lewis H. Kuller, Emma J. Barinas-Mitchell, Daniel Edmundowicz, Akira Sekikawa

    CIRCULATION   135   2017年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Prevalence Of Intracranial Artery Stenosis and the Association With Conventional Risk Factors of Cardiovascular Diseases in a General Population of Japanese: SESSA Study

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Torii Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION   135   2017年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 日常的歩行運動レベルが左心房拡大,心房細動発症に与える影響-地域住民7年追跡研究-

    山添正博, 久松隆史, 大野聖子, 有馬久富, 三浦克之, 上島弘嗣

    若手研究者のための健康科学研究助成成果報告書   ( 32 )   108 - 113   2017年

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    記述言語:日本語   出版者・発行元:(公財)明治安田厚生事業団  

    草津市に在住する40〜79歳の一般男性から無作為抽出した983名を対象とし、歩数計で測定した日常的歩行運動レベルと左心房拡大との関連について7年間の追跡調査を行った。歩数を含む諸因子を独立変数として重回帰分析を行った。その結果、左心房拡大に関連する独立した因子の一つとして「歩数の増加」が抽出された。

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連:滋賀潜在性動脈硬化研究(SESSA)

    宮澤伊都子, 大久保孝義, 藤吉朗, 久松隆史, 門田文, 村上陽子, 永谷幸裕, 門脇紗也佳, 村田喜代史, 前川聡, 三浦克之, 三浦克之, 上島弘嗣

    日本循環器病予防学会誌   52 ( 2 )   201 - 201   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討:パイロット研究

    宮川尚子, 有馬久富, 由田克士, 奥田奈賀子, 大久保孝義, 久松隆史, 近藤慶子, 三浦克之

    日本循環器病予防学会誌   52 ( 2 )   171 - 171   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連:滋賀動脈硬化疫学研究SESSA

    炭昌樹, 久松隆史, 久松隆史, 藤吉朗, 門田文, 門田文, 宮川尚子, 近藤慶子, 門脇紗也佳, 鈴木仙太朗, 鳥居さゆ希, 鳥居さゆ希, MARYAM Zaid, 佐藤敦, 有馬久富, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 2 )   183 - 183   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 NIPPON DATA2010イベント判定委員会

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)   21‐24 (WEB ONLY)   2017年

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    記述言語:日本語  

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  • 一般地域男性住民における高い睡眠呼吸障害有所見率とその要因-SESSA研究-

    高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 鳥居さゆ希, 佐藤敦, 宮川尚子, 門田文, 門田文, 有馬久富, 有馬久富, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本疫学会学術総会講演集(Web)   27th   150 (WEB ONLY)   2017年

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 久松隆史, 久松隆史, 三浦克之, 有馬久富, 門田文, 門脇紗也佳, 鳥居さゆ希, 鈴木仙太朗, 宮川尚子, 佐藤敦, 藤吉朗, 大久保孝義, アボット ロバート, 関川暁, 堀江稔, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   112 (WEB ONLY) - 112   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較,及びその差に影響を及ぼす要因の検討:滋賀動脈硬化疫学研究(SESSA)

    門脇紗也佳, 寳澤篤, 藤吉朗, 久松隆史, 佐藤敦, 田中佐智子, 岡村智教, 大久保孝義, 三浦克之, 三浦克之, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   40th   408 - 408   2017年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 非肥満者に対する保健指導方法の開発に関する研究 非肥満者を含む集団への生活習慣に関する介入研究の文献レビュー

    宮本恵宏, 岡村智教, 岡山明, 磯博康, 三浦克之, 小川佳宏, 荒木田美香子, 東山綾, 竹上未紗, 渡邉至, 小久保喜弘, 西村邦宏, 中村文明, 渡邉琢也, 辰巳友佳子, 杉山大典, 桑原和代, 原田成, 竹内文乃, 栗原綾子, 深井航太, 飯田美穂, 平田あや, 深井航太, 飯田美穂, 平田あや, 平田匠, 崔仁哲, 宮澤伊都子, 久松隆史, 鳥居さゆ希, 山添正博, 坊内良太郎, 松田有子

    非肥満者に対する保健指導方法の開発に関する研究 平成28年度 総括・分担研究報告書(宮本恵宏)(Web)   2017年

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  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    近藤慶子, 有馬久富, 久松隆史, 藤吉朗, 門田文, 関川暁, 鳥居さゆ希, 鈴木仙太朗, 椎野顯彦, 野崎和彦, 宮川尚子, 前川聡, 村田喜代史, 三浦克之, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   195 - 195   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Comparison of anthropometric measures of obesity in the association with coronary artery calcification in the general Japanese population

    Y. Sugimoto, T. Hisamatsu, K. Miura, S. Kadowaki, A. Kadota, M. Zaid, S. Torii, N. Miyagawa, A. Satoh, Y. Saitoh, M. Yamazoe, H. Arima, A. Fujiyoshi, A. Sekikawa, H. Ueshima

    EUROPEAN HEART JOURNAL   37   546 - 546   2016年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS  

    Web of Science

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  • Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition? 査読

    Satoh Atsushi, Arima Hisatomi, Hozawa Atsushi, Hisamatsu Takashi, Kadowaki Sayaka, Kadota Aya, Fujiyoshi Akira, Miyagawa Naoko, Zaid Maryam, Torii Sayuki, Ohkubo Takayoshi, Okamura Tomonori, Sekikawa Akira, Miura Katsuyuki, Ueshima Hirotsugu

    CIRCULATION   133   2016年3月

  • Significant Inverse Association of Blood Levels of Marine Omega-3 Fatty Acids with Coronary Artery Calcification in Men in Japan

    Akira Sekikawa, Marnie Bertolet, Abhishek Vishnu, Vasudha Ahuja, Rhobert W. Evans, Lewis H. Kuller, Akira Fujiyoshi, Takashi Hisamatsu, Takashi Kadowaki, Aya Kadota, Sayaka Kadowaki, Hisatomi Arima, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION   133   2016年3月

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  • Re-evaluation of Prognostic Values of Clockwise and Counterclockwise Rotation for Total and Cardiovascular Mortality in a Different Cohort (20 Year Follow-up of NIPPON DATA90)

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    日本循環器学会近畿地方会(Web)   121st   KINKI121,D07 (WEB ONLY)   2016年

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    日本循環器病予防学会誌   51 ( 2 )   114 - 114   2016年

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  • 客観的に評価された歩数値とメタボリック症候群発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

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    日本循環器病予防学会誌   51 ( 2 )   120 - 120   2016年

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

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  • 睡眠時間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究(SESSA)

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  • THE ASSOCIATION BETWEEN VASCULAR RISK FACTORS AND OVER ACTIVE BLADDER

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  • 滋賀医科大学アジア疫学研究センターの取り組み NCD克服のための疫学研究・教育拠点を目指して

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    記述言語:日本語   出版者・発行元:滋賀医科大学  

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  • Modified LDL (serum level of LOX-1 ligand containing ApoB) was associated with increased carotid intima-media thickness in Japanese community dwelling men especially with hypercholesterolemia

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  • Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan.

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 10.日本人一般男性において長鎖n3脂肪酸の高摂取は心疾患死亡リスクにおける安静的心拍数上昇の影響を減弱させる

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 24.日本人一般住宅における早期再分極:日本循環器疾患基礎調査からの新たな知見

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 7.日本人一般男性における心疾患死亡リスクに対する早期再分極とn-3不飽和脂肪酸摂取量との交互作用の検討

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 国民健康・栄養調査(2008-2010年)における血圧測定精度の検討:INTERMAP日本研究との比較

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  • 日本人一般男性集団における脈波伝播速度と冠動脈石灰化との関連:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

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    日本高血圧学会総会プログラム・抄録集   35th   401 - 401   2012年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • Effect modification of dietary n-3 fatty acids on cardiovascular mortality risk by resting heart rate general population:NIPPON DATA80

    T Hisamatsu, K Miura, T Ohkubo, N Okuda, Y Murakami, N Miyagawa, M Horie, T Okamura, A Okayama, H Ueshima

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  • Interaction of Dietary n-3 Fatty Acids on Cardiac Risk by J-point elevation in japanese Men: NIPPON DATA.

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Akira Fujiyoshi, Naoyuki Takashima, Aya Kadota, Nagako Okuda, Akira Okayama, Hirotsugu Ueshima

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    記述言語:日本語   出版者・発行元:(一社)日本臨床リウマチ学会  

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    奈良県医師会透析部会誌   15 ( 1 )   128 - 129   2010年

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  • 血液透析患者に発症した深部静脈血栓症に対して下大静脈フィルター留置後血栓溶解療法を施行した1例

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    日本透析医学会雑誌   42 ( Supplement 1 )   699 - 699   2009年

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  • 上腕アプローチよりF-Pバイパスに対してPTAを施行した1例

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  • 経皮的血管縫合デバイス(パークローズAT)使用後に急性大腿動脈閉塞症を合併した1症例

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  • 敗血症性肺塞栓にて発症した心室中隔欠損症に伴う感染性心内膜炎の一例

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    記述言語:英語  

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  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連:滋賀動脈硬化疫学研究

    久松隆史, 大久保孝義, 藤吉朗, 鳥居さゆ希, 瀬川裕佳, 近藤慶子, 門田文, 高島直敬, 設楽智史, 有馬久富, 中川義久, 渡邉嘉之, 椎野顯彦, 野崎和彦, 上島弘嗣, 三浦克之

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    開催年月日: 2021年1月27日 - 2021年1月29日

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  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率:益田研究

    久松隆史, 福田茉莉, 谷口かおり, 宮川健, 中畑典子, 神田秀幸

    第79回日本公衆衛生学会総会 

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    開催年月日: 2020年10月20日 - 2020年10月22日

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  • 海外留学ネットワーキングセミナー 招待

    久松隆史

    第84回日本循環器学会学術集会 

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    開催年月日: 2020年7月27日 - 2020年8月2日

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  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田 茉莉, 神田秀幸

    第30回日本疫学会学術総会 

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    開催年月日: 2020年2月20日 - 2020年2月22日

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討, NIPPON DATA80.

    久松隆史, 三浦克之, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 早川岳人, 神田秀幸, 岡村智教, 岡山明, 上島弘嗣

    第42回日本高血圧学会総会  2019年 

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    開催年月日: 2019年10月25日 - 2019年10月27日

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  • 島根県益田市におけるIoTを活用した血圧管理プロジェクト 招待

    久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    第1回Digital Hypertension Conference  2019年10月25日 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA 招待

    Takashi Hisamatsu

    Cardiovascular Epidemiology Seminar Series, Northwestern University  2019年1月25日 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study

    Hisamatsu T, Miura K, Fujiyoshi A, Kunimura A, Shiino A, Nozaki K, Arima H, Ohkubo T, Ueshima H

    第83回日本循環器学会学術集会  2019年 

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  • The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) 招待

    IDACO/IDHOCO/IDCARS Consortium Meeting 2019  2019年 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • The Association between Coronary Artery Calcium and the Cerebral Small Vessel Disease

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • Association of serum N-3 polyunsaturated fatty acids and high-sensitivity C-reactive protein in Japanese general population from Shiga Epidemiological Study of Subclinical Arteriosclerosis

    第82回日本循環器学会学術集会  2018年 

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • Gut microbiota and coronary artery calcification in a general population of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis

    第82回日本循環器学会学術集会  2018年 

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  • A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1

    第82回日本循環器学会学術集会  2018年 

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  • Objectively measured step counts was independently associated with higher cognition in apparently healthy Japanese men

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men

    第52回日本アルコール・アディクション医学会学術集会  2017年 

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    49回日本動脈硬化学会総会・学術集会  2017年 

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  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    49回日本動脈硬化学会総会・学術集会  2017年 

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連

    第53回日本循環器病予防学会学術集会  2017年 

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討 パイロット研究

    第53回日本循環器病予防学会学術集会  2017年 

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連

    第53回日本循環器病予防学会学術集会  2017年 

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  • NMR lipoprotein particle distributions and coronary artery calcium in US White and Japanese men aged 40-49 years

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • Prevalence of Intracranial Artery Stenosis and the Association with Conventional Risk Factors of Cardiovascular Dieseases in a General Population of Japanese.

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • Lower eGFR and proteinuria were independently associated with lower cognitive abilities in community-dwelling men in Japan

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較、及びその差に影響を及ぼす要因の検討

    第40回日本高血圧学会総会  2017年 

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  • 客観的に評価された歩数値とメタボリック症候群との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    第52回日本循環器病予防学会学術集会  2016年 

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  • Blood pressure measurement in the National Survey in Japan and the future plan for non-mercury era

    The 26th Scientific Meeting of the International Society of Hypertension  2016年 

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  • Smoking, smoking cessation and measures of subclinical atherosclerosis in multiple vascular meds in Japanese men.

    ESC CONGRESS 2016.  2016年 

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  • 潜在性動脈硬化の規定要因:ERA JUMP、SESSAより 招待

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    第47回日本動脈硬化学会総会・学術集会  2015年 

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    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

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  • The High Prevalence of Early Repolarization in Genotyped Long QT Syndrome

    Hasegawa K, Watanabe H, Hisamatsu T, Sonoda K, Ohno S, Itoh H, Ashihara T, Makiyama T, Hayashi H, Horie M

    第78回日本循環器学会総会・学術集会 

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    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • Early repolarization in Japanese general population: new findings from the National Surveys of Circulatory Disorders of Japan (NIPPON DATA)

    Hisamatsu T, Miura K, Ohkubo T, Okamura A, Okayama A, Ueshima H

    第78回日本循環器学会総会・学術集会 

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    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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受賞

  • 岡山大学SDGs推進表彰 President Award 岡山県クラスター対策班

    2021年  

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  • 岡山公衆衛生学研究会緒方賞

    2020年  

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  • 日本循環器病予防学会奨励賞

    2018年  

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    受賞国:日本国

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  • 島根大学医学部若手研究者優秀論文賞

    2017年  

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    受賞国:日本国

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  • 日本動脈硬化学会若手研究者奨励賞

    2017年  

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    受賞国:日本国

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  • 日本心臓病学会上田賞

    2015年  

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    受賞国:日本国

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共同研究・競争的資金等の研究

  • 「予防・健康づくりに関する大規模実証事業 (運動、栄養、女性の健康、がん検診)」食行動の変容に向けた尿検査及び食環境整備に係る実証事業

    2020年12月 - 2022年03月

    厚生労働省 

    久松隆史

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    担当区分:研究分担者 

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  • 家庭血圧の長期縦断研究からみた血圧変動の共振現象及び無症候性脳血管障害との関連

    研究課題/領域番号:20K10529  2020年04月 - 2023年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    久松 隆史, 神田 秀幸, 三浦 克之

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    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

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  • 血圧変動共振現象の病態解明を目指したWithコロナ時代における遠隔化・省人化・非接触型コホート研究の基盤開発

    2020年 - 2025年

    公益財団法人岡山医学振興会 

    久松隆史

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    担当区分:研究代表者 

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  • IoT技術を活用した長期にわたり評価された家庭血圧管理状況と血圧変動要因に関する探索的観察研究

    2018年

    共同研究(オムロンヘルスケア株式会社) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 一般日本人女性における不整脈の実態解明と時間医学モデルの構築

    研究課題/領域番号:17K15827  2017年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    久松 隆史

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    研究代表者らは、過去10年以上にわたり、草津市の一般男性約1500名を対象に動脈硬化・認知症に関する疫学研究を実施してきた(日米比較研究ERAJUMP・滋賀動脈硬化疫学研究SESSA、代表者 上島弘嗣(滋賀医科大学))。平成27年からは、新たに同地域の一般女性約800名を対象に同様の疫学研究(SESSA Women、代表者 三浦克之(同大学))を実施中である。本申請研究では、SESSA Women研究における平成29‐31年の参加者を研究対象とし、24時間心電図検査(FM-800,フクダ電子)を追加実施した。
    1)調査の実施:約200名の対象者に対して、24時間心電図を実施した。対象者には、事前に研究者から研究内容の説明を行い、研究参加の同意を得た。検査結果については、医師が最終判定を行い、コメントと共に対象者に返却した。
    2)データの整理・統合データベースの作成:昨年度実施分の24時間心電図データについて、漸次データクリーニングを行った。昨年度実施分の24 時間心電図関連データベースとSESSA Women 研究データベースを統合したデータベースを完成させた。
    3)データの解析、報告:統合データベースを用いて、24 時間心電図解析に基づく、不整脈(心房細動・期外収縮、等)の定性的・定量的指標、日内変動と、以下の項目との関連について横断的な解析を行った。
    1.生活習慣、食習慣、病歴・服薬状況、心理社会的指標、歩数値・活動量、2.肥満指標、血圧値、血液尿生化学指標、炎症・心臓バイオマーカー、運動機能・フレイル、3.認知機能、4.無症候性脳動脈硬化(ラクナ梗塞、白質病変、微小出血、脳動脈狭窄、等)、脳萎縮

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  • Japanese Paradoxに着目した心血管病の病態理解と新リスク要因の解明

    2016年 - 2019年

    科学研究費補助金(海外特別研究員) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    2016年 - 2018年

    民間学術研究振興費補助金(上原記念生命科学財団) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 筋由来の新規生理活性物質イリシンが肥満・糖尿病・動脈硬化に及ぼす影響の検討

    研究課題/領域番号:15K19224  2015年04月 - 2017年03月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    久松 隆史

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    筋由来生理活性物質(マイオカイン)の一種であるイリシンについて、肥満・糖尿病・脂質などの代謝指標および動脈硬化指標との関連を明らかにすることを目的とした。心血管病の既往のない健常一般集団(40-79歳)において、血清イリシンは、肥満・脂質指標と負の関連を認め、肥満・糖尿病・脂質指標を含む交絡因子を調整後も冠動脈石灰化進展と負の関連を認めた。イリシンが心血管病や代謝性疾患を予防するかどうかを含め今後更なる研究の実施が望まれる。

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  • 筋強直性ジストロフィー患者の心電図の経時的分析による致死性不整脈の因子分析とデバイス適応の検討

    2015年 - 2019年

    厚生労働科学研究費補助金 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 日本人一般集団におけるCOPDの有病率及び潜在性動脈硬化指標との関連に関する検討

    2015年 - 2017年

    科学研究費補助金(基盤研究C) 

    中野恭幸

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    資金種別:競争的資金

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  • 一般住民において腸内細菌叢が潜在性動脈硬化の進展におよぼす影響

    2015年 - 2017年

    科学研究費補助金(基盤研究B) 

    有馬久富

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    資金種別:競争的資金

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  • 一般日本人女性における潜在性動脈硬化と脳萎縮の実態解明

    2015年 - 2017年

    科学研究費補助金(基盤研究A) 

    三浦克之

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    資金種別:競争的資金

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  • 筋・肝・腹部脂肪が糖・インスリン代謝に及ぼす影響:地域住民7年追跡コホート研究(分担)

    2014年 - 2017年

    科学研究費補助金(基盤研究B) 

    藤吉朗

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    資金種別:競争的資金

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  • 認知機能低下・海馬萎縮に関連する心臓調律異常の疫学的検証

    2014年 - 2015年

    民間学術研究振興費補助金(花王健康科学研究会) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 日本人一般集団における心拍変動スペクトル指標と無症候性脳血管障害との関連の探求

    研究課題/領域番号:25893097  2013年08月 - 2015年03月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    久松 隆史

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    配分額:2730000円 ( 直接経費:2100000円 、 間接経費:630000円 )

    自律神経機能を反映する心拍変動(HRV)指標と脳卒中との関連は一般人口集団においてほとんど解明されていない。本研究では、循環器疾患既往のない日本人一般地域住民からの無作為抽出集団において、24時間心電図から定量化したHRV指標と頭部MRI検査を用いて評価した無症候性脳血管障害との関連を横断的に検討することを目的とした。夜間帯(2時-2時15分)および24時間の時間領域解析指標SDNN、周波数領域解析指標LF、HF、LF/HF比は、ラクナ梗塞、微小出血、白質病変、脳動脈狭窄など無症候性脳血管障害と有意な関連を認めなかった。日本人一般住民において、HRV指標は無症候性脳血管障害と関連がなかった。

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  • 動脈硬化の進展にかかわる新しいバイオマーカーの探索(分担)

    2013年 - 2016年

    科学研究費補助金(基盤研究A) 

    上島弘嗣

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    資金種別:競争的資金

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  • 地域住民における無症候性脳血管障害・海馬萎縮の関連要因:コホート東西比較(分担)

    2011年 - 2014年

    科学研究費補助金(基盤研究A) 

    三浦克之

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    資金種別:競争的資金

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担当授業科目

  • 公衆衛生学 (2021年度) 特別  - その他

  • 公衆衛生学実習 (2021年度) 特別  - その他

  • 公衆衛生学I(演習・実習) (2021年度) 特別  - その他

  • 公衆衛生学I(講義・演習) (2021年度) 特別  - その他

  • 公衆衛生学II(演習・実習) (2021年度) 特別  - その他

  • 公衆衛生学II(講義・演習) (2021年度) 特別  - その他

  • 研究方法論応用 (2021年度) 特別  - その他

  • 公衆衛生学 (2020年度) 特別  - その他

  • 公衆衛生学実習 (2020年度) 特別  - その他

▼全件表示

 

社会貢献活動

  • 血圧・脂質異常症・糖尿病の基本的検査の意義と結果の見方

    役割:講師

    日本循環器病予防学会  保健指導レベルアップセミナー  2021年1月23日

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    種別:講演会

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  • IoT技術を活用した家庭血圧管理と脳卒中予防に向けた取り組み

    役割:講師

    島根県益田市  2020年1月24日

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  • 生活習慣と高血圧症

    役割:講師

    益田地域医療センター医師会病院  2019年12月6日

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    種別:会誌・広報誌

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  • 高血圧治療ガイドライン2019の概要と高血圧予防、高血圧管理の重要性

    役割:講師

    島根県  島根県脳卒中対策及び糖尿病対策研修会  2019年11月5日

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    種別:講演会

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  • タバコは全身の血管を老化させる

    役割:寄稿

    ヘルスアップ21  2017年11月

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    種別:新聞・雑誌

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  • 尿クレアチニン・アルブミン比, 家庭血圧, 尿ナトカリ比

    役割:取材協力, 助言・指導

    益田ヘルスケア推進協会  益田ヘルスケア通信  2021年5月

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    種別:会誌・広報誌

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  • 高血圧と新型コロナウィルス感染症

    役割:編集, 助言・指導

    益田ヘルスケア推進協会  益田ヘルスケア通信  2020年10月

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    種別:会誌・広報誌

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  • IoT技術を活用した家庭血圧管理と脳卒中予防に向けた取り組み

    役割:講師

    島根県益田市  2019年9月20日

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    種別:講演会

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  • 40代から増える脳卒中

    役割:取材協力

    タウン情報Lazuda  2017年2月

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    種別:新聞・雑誌

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  • 脳卒中や心筋梗塞にならないための生活のコツ

    役割:講師

    2016年12月3日

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    種別:講演会

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メディア報道

  • 世界一受けたい授業 岡山県共生高校eスポーツ部 テレビ・ラジオ番組

    日本テレビ  世界一受けたい授業  2020年11月7日

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