2024/05/22 更新

写真a

ヒサマツ タカシ
久松 隆史
HISAMATSU Takashi
所属
医歯薬学域 准教授
職名
准教授
外部リンク

学位

  • 博士(医学) ( 滋賀医科大学 )

研究キーワード

  • 公衆衛生学

  • 循環器病学

  • メタボローム

  • メンデルランダム化

  • 予防医学

  • 腸内細菌

  • 疫学

  • 高血圧

  • 遺伝子

  • 心不全

  • IoT

  • COVID-19

  • AI

  • ビックデータ

  • 衛生学

  • 分子疫学

研究分野

  • ライフサイエンス / 循環器内科学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 医療管理学、医療系社会学

学歴

  • 滋賀医科大学   Graduate School of Medicine  

    2009年4月 - 2013年3月

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    国名: 日本国

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  • 滋賀医科大学   Undergraduate School of Medicine   Faculty of Medicine

    1997年4月 - 2003年3月

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    国名: 日本国

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経歴

  • 岡山大学   学術研究院医歯薬学域   准教授

    2020年1月 - 現在

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  • 日本学術振興会海外特別研究員 Northwestern University Feinberg School of Medicine(留学)

    2017年2月 - 2019年1月

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  • 滋賀医科大学   社会医学講座公衆衛生学部門   客員准教授

    2016年4月 - 現在

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  • 島根大学   環境保健医学講座   准教授

    2016年4月 - 2019年12月

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  • 滋賀医科大学   アジア疫学研究センター (現NCD疫学研究センター)   特任助教

    2013年4月 - 2016年3月

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  • Northwestern University Feinberg School of Medicine   非常勤講師

    2019年2月

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  • 滋賀医科大学   循環器内科   医員

    2011年4月 - 2013年3月

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  • 大阪回生病院   循環器内科   医員

    2008年4月 - 2011年3月

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  • 日本赤十字社長浜赤十字病院   循環器内科   医員

    2005年6月 - 2008年3月

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  • 滋賀医科大学   内科   医員

    2003年5月 - 2005年5月

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所属学協会

  • 日本疫学会(代議員)

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  • 日本内科学会

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  • 日本循環器学会

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  • 日本公衆衛生学会

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  • 日本動脈硬化学会(評議員)

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  • 日本循環器病予防学会(評議員)

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  • 日本心臓病学会

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  • 日本高血圧学会(評議員)

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  • 日本アルコール・アディクション医学会(評議員)

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委員歴

  • 日本疫学会   学術委員会社会実装推進ワーキンググループ委員/選挙規定検討委員会委員  

    2024年2月   

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  • 日本循環器病予防学会   総務委員会委員  

    2023年10月   

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  • 健康市民おかやま21次期計画策定専門家会議委員  

    2023年4月   

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  • Hypertension Research 編集委員  

    2023年4月   

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  • 日本高血圧学会 他学会ガイドライン対応WG/厚労省実証事業TF  

    2022年10月   

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  • 医療系大学間共用試験実施評価機構医学系CBT実施小委員会   ブラッシュアップ専門部会委員  

    2021年6月   

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  • 岡山県新型コロナウィルスクラスター対策班   専門家  

    2020年9月   

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  • 島根県益田市・一般社団法人益田ヘルスケア推進協会   理事  

    2019年7月   

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    団体区分:学協会

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  • Korean Circulation Journal 編集委員  

    2017年11月   

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    団体区分:学協会

    The Korean Society of Cardiology (Korea)

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  • 日本公衆衛生学会   日本公衆衛生雑誌査読委員  

    2024年4月   

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  • 日本疫学会 疫学研究推進WG委員/選挙規定検討委員会委員  

    2022年4月   

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  • 倉敷市保健所   医療コーディネーター(新型コロナウィルス対策班)  

    2021年9月   

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  • 健康市民おかやま21推進会議   評価部会委員  

    2020年7月   

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  • 島根県出雲市脳卒中予防対策検討会議   委員  

    2019年4月   

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  • 島根県感染症発生動向調査委員会   委員  

    2019年4月   

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  • 島根県出雲圏域健康長寿しまね推進会議   委員  

    2019年4月   

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  • 島根県保健環境科学研究所・原子力環境センター調査研究課題検討委員会   委員  

    2019年4月   

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論文

  • IoT技術を用いた家庭血圧管理研究の5年間の成果と時系列ビックデータ・AIを活用した今後の展望:益田研究 査読

    久松隆史, 絹田皆子, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    岡山医学会雑誌   2024年

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    担当区分:筆頭著者, 責任著者  

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  • High blood pressure and colorectal cancer mortality in a 29-year follow-up of the Japanese general population: NIPPON DATA80. 査読 国際誌

    Takashi Hisamatsu, Aya Kadota, Takehito Hayakawa, Yoshikuni Kita, Akiko Harada, Yukiko Okami, Keiko Kondo, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura

    Hypertension research : official journal of the Japanese Society of Hypertension   47 ( 1 )   206 - 214   2023年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Onco-hypertension has been proposed, although associations of high blood pressure (BP) with cancer risk remain inconsistent. We examined associations of high BP with risk of mortality from stomach, lung, colorectal, liver, and pancreatic cancers independent of possible confounders in an analysis that excluded deaths within the first 5 years of follow-up to consider the reverse causality. In a prospective cohort representative of the general Japanese population (1980-2009), we studied 8088 participants (mean age, 48.2 years; 56.0% women) without clinical cardiovascular disease or antihypertensive medication at baseline. Fine-Gray competing risks regression was used to estimate hazard ratios for 10 mmHg higher BP adjusted for confounders including smoking, alcohol-drinking, obesity, and diabetes mellitus. During 29-year follow-up, 159 (2.0%), 159 (2.0%), 89 (1.1%), 86 (1.1%), and 68 (0.8%) participants died from stomach, lung, colorectal, liver, and pancreatic cancers, respectively. We observed a positive association of high BP with risk of colorectal cancer mortality but not with mortality risks from any other cancers. The association with colorectal cancer mortality for systolic and diastolic BP was evident in those aged 30-49 years (hazard ratios 1.43 [95% confidence interval, 1.22-1.67] and 1.86 [1.32-2.62], respectively) but not in those aged 50-59 years and ≥60 years (P for age interaction <0.01 for systolic and diastolic BP). The associations with colorectal cancer mortality were similar in the analyses stratified by smoking, alcohol-drinking, obesity, and diabetic status. In conclusion, high BP among young to middle-aged adults was independently associated with risk of colorectal cancer mortality later in life.

    DOI: 10.1038/s41440-023-01497-3

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  • Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis. 査読

    Takashi Hisamatsu, Yasuharu Tabara, Aya Kadota, Sayuki Torii, Keiko Kondo, Yuichiro Yano, Akihiko Shiino, Kazuhiko Nozaki, Tomonori Okamura, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of atherosclerosis and thrombosis   31 ( 2 )   135 - 147   2023年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: It remains inconclusive regarding alcohol intake and stroke risk because determining risk factors depends on the specific pathogenesis of stroke. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in cerebral small- and large-vessel diseases. METHODS: We studied 682 men (mean age, 70.0 years), without stroke, in a cross-sectional Mendelian randomization analysis. We assessed small-vessel diseases (SVDs), which comprised lacunar infarcts, white matter hyperintensities (WMHs), and cerebral microbleeds, and large intracranial artery stenosis (ICAS) on brain magnetic resonance imaging. RESULTS: The median (25%tiles, 75%tiles) alcohol consumption by ALDH2-rs671 inactive A allele (n=313 [45.9%]) and non-A allele (n=369 [54.1%]) carriers was 3.5 (0.0, 16.0) and 32.0 (12.9, 50.0) g/day, respectively. Non-A allele carriers had higher prevalent hypertension and lower low-density lipoprotein cholesterol concentrations than A allele carriers. In age-adjusted ordinal logistic regression for graded burden, odds ratios (95% confidence intervals) for total SVDs, lacunar infarcts, WMHs, cerebral microbleeds, and ICAS in non-Aallele carriers were 1.46 (1.09-1.94), 1.41 (0.95-2.08), 1.39 (1.05-1.85), 1.69 (1.06-2.69), and 0.70 (0.50-0.98), respectively, compared with A allele carriers. These associations attenuated to statistical non-significance after considering covariates and amount of alcohol intake. CONCLUSIONS: Our findings suggest a positive association of alcohol consumption with risk of cerebral SVDs and its inverse association with risk of large-vessel disease through intermediaries, such as hypertension or low-density lipoprotein cholesterol. These findings provide insight into potential causal mechanisms linking alcohol consumption with stroke risk.

    DOI: 10.5551/jat.64222

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  • Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis. 査読

    Yosuke Higo, Takashi Hisamatsu, Yoshihisa Nakagawa, Yuichi Sawayama, Yuichiro Yano, Aya Kadota, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Yoshiyuki Watanabe, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of atherosclerosis and thrombosis   31 ( 1 )   48 - 60   2023年8月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Few studies have compared the strength in the associations of anthropometric and computed tomography (CT)-based obesity indices with coronary artery calcification (CAC), aortic artery calcification (AoAC), and aortic valve calcification (AVC). METHODS: We assessed cross-sectcional associations of anthropometric and CT-based obesity indices with CAC, AoAC, and AVC. Anthropometric measures included body mass index (BMI), waist circumference, hip ircumference, waist-to-hip circumference ratio, and waist-to-height ratio in 931 men (mean age, 63.7 years) from a population-based cohort. CT images at the L4/5 level were obtained to calculate the areas of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), total adipose tissue (TAT), VAT-to-SAT ratio (VSR), and VAT-to-TAT ratio (VTR). CAC, AoAC, and AVC were quantified using the Agatston score based on CT scanning. RESULTS: CAC, AVC, and AoAC were present in 348 (62.6%), 173 (18.6%), and 769 (82.6%) participants, respectively. In multivariable models adjusting for age, lifestyle factors, and CT types (electron beam CT and multidetector row CT), anthropometric and CT-based obesity indices were positively associated with CAC (p<0.01). Conversely, VAT-to-SAT ratio and VAT-to-TAT ratio were positively associated with AoAC (p<0.01). Any obesity indices were not associated with AVC. CONCLUSIONS: The strength of the associations of obesity indices with subclinical atherosclerosis varied according to the anatomically distinct atherosclerotic lesions, among men.

    DOI: 10.5551/jat.64096

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  • Associations of indoor and outdoor temperatures and their difference with home blood pressure: The Masuda Study 査読 国際誌

    Minako Kinuta, Takashi Hisamatsu, Mari Fukuda, Kaori Taniguchi, Sho Komukai, Noriko Nakahata, Hideyuki Kanda

    Hypertension Research   46 ( 1 )   200 - 207   2022年10月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Ambient temperature and blood pressure (BP) are closely related; however, few studies have examined the association of out-of-office BP with indoor or outdoor temperature. The effect of the difference between indoor and outdoor temperatures on BP also remains unknown. Therefore, this study aimed to investigate the association of indoor and outdoor temperatures and their difference with home BP. We studied healthy 352 participants (mean age, 49.8 years; 46.0% women) from a population-based cohort using 2-year data on temperature and self-measured home BP. We measured home BP and indoor temperature at the same time in the morning and evening every day. Outdoor temperature during the same period was based on national data. We observed 82,900 home BP measurements in the morning and 66,420 in the evening. In the mixed-effects model adjusted for age, sex, and possible confounders, indoor temperature was inversely associated with systolic and diastolic BP in the morning and evening. A 1 °C increase in indoor temperature reduced systolic and diastolic BP by 0.37 and 0.22 mmHg, respectively, in the morning and by 0.45 and 0.30 mmHg, respectively, in the evening (all P-values<0.001). The magnitude of associations was stronger for indoor than outdoor temperature. Similarly, a 1 °C increase in indoor temperature above outdoor temperature decreased systolic and diastolic BP by 0.33 and 0.12 mmHg, respectively, in the morning and by 0.45 and 0.26 mmHg, respectively, in the evening independent of outdoor temperature (all P-values <0.001). In conclusion, controlling indoor temperature is important to stabilize home BP levels.

    DOI: 10.1038/s41440-022-01059-z

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    その他リンク: https://www.nature.com/articles/s41440-022-01059-z

  • Alcohol consumption and subclinical and clinical coronary heart disease: A Mendelian randomization analysis 査読 国際誌

    Hisamatsu T, Miura K, Tabara Y, Sawayama Y, Kadowaki T, Kadota A, Torii S, Kondo K, Yano Y, Fujiyoshi A, Yamamoto T, Nakagawa Y, Horie M, Kimura T, Okamura T, Ueshima H, for the SESSA, ACCESS Research Groups

    European Journal of Preventive Cardiology   29 ( 15 )   2006 - 2014   2022年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/eurjpc/zwac156

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  • Association of ambulatory blood pressure with aortic valve and coronary artery calcification. 査読 国際誌

    Yuichi Sawayama, Takashi Hisamatsu, Aya Kadota, Sayuki Torii, Keiko Kondo, Akira Fujiyoshi, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of hypertension   40 ( 7 )   1344 - 1351   2022年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. METHODS: In this population-based, cross-sectional study, we assessed office BP, mean ambulatory BP (24-h, awake, and asleep), and variability of ambulatory BP, as determined by the coefficient of variation (awake and asleep). AVC and CAC were quantified using an Agatston score (>0) based on computed tomography scanning. We calculated relative risks (RRs) and 95% confidence intervals (CIs) with a 1-standard deviation increment in each BP index for the presence of AVC and CAC using a multivariate-adjusted Poisson regression with robust error variance. RESULTS: Of 483 participants (mean age: 66.8 years), 154 (31.9%) and 310 (64.2%) had AVC and CAC, respectively. The presence of AVC was associated with office systolic BP (SBP; RR, 1.15; 95% CI, 1.03-1.28), awake diastolic BP (DBP) variability (RR, 1.12; 95% CI, 1.01-1.25), and asleep SBP variability (RR, 1.14; 95% CI, 1.03-1.27). The presence of CAC was associated with office SBP (RR, 1.08; 95% CI, 1.01-1.15), mean 24-h SBP (RR, 1.10; 95% CI, 1.04-1.16), mean awake SBP (RR, 1.11; 95% CI, 1.04-1.17), mean asleep SBP (RR, 1.07; 95% CI, 1.01-1.13), and asleep SBP variability (RR, 1.07; 95% CI, 1.01-1.13). CONCLUSION: These findings highlight the association of ambulatory BP indices with both AVC and CAC, but with different effects on their presences.

    DOI: 10.1097/HJH.0000000000003147

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  • Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men. 査読 国際誌

    Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

    The American journal of cardiology   169   51 - 56   2022年4月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79 years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, lipid-lowering therapy were included in multivariable negative binomial regression to assess independent correlates for the number of VPCs per hour. We observed at least 1 VPC in 1 hour in 429 men (83%). In multivariable negative binomial regression adjusted for all covariates simultaneously, age (risk ratio [95% confidence interval] 1.91 [1.56 to 2.33] per 1-SD increment), height (1.17 [1.04 to 1.49] per 1-SD increment), resting heart rate(1.34 [1.02 to 1.77] per 1-SD increment), diabetes mellitus (2.36 [1.17 to 4.76] ), hypertension (1.90 [1.03 to 3.50]), physical activity (0.67 [0.47 to 0.97] ), current smoking (4.23 [1.86 to 9.60] ), past smoking (2.08 [1.03 to 4.19] ), current light alcohol consumption (0.16 [0.04 to 0.64] ), and lipid-lowering therapy (0.47 [0.23 to 0.96] ) were independently associated with VPCs frequency. In conclusion, VPCs frequency was independently associated with age, height, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy.

    DOI: 10.1016/j.amjcard.2021.12.046

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  • Home blood pressure variability and target organ damage. 招待 査読 国際誌

    Takashi Hisamatsu, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension   45 ( 3 )   543 - 545   2022年3月

  • The association between problematic Internet use and neck pain among Japanese schoolteachers 査読 国際誌

    Tanabe R, Hisamatsu T, Fukuda M, Tsumura H, Tsuchie R, Suzuki M, Sugaya N, Nakamura K, Takahashi K, Kanda H

    63 ( 1 )   e12298 - 9 of 9   2021年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/1348-9585.12298

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  • Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. 査読 国際誌

    Takashi Hisamatsu, Donald M Lloyd-Jones, Laura A Colangelo, Kiang Liu

    Journal of hypertension   39 ( 8 )   1586 - 1593   2021年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Data are sparse regarding the impact of sodium and potassium intakes on serial blood pressure (BP) levels during long-term follow-up. METHODS: Among 1007 Coronary Artery Risk Development in Young Adults participants (mean age, 30.2 years; 53% blacks; 57% women) who had at least two 24-h urine samples collected at year 5 (Y5) examination, we assessed associations of urinary sodium and potassium excretions with BP trends and incident hypertension in the subsequent 25 years. Participants were classified by sex-specific medians for averaged 24-h urinary excretions: lower sodium and higher potassium (Na-Lo-K-Hi); higher sodium and lower potassium (Na-Hi-K-Lo); and others. RESULTS: In the adjusted generalized estimating equation model, SBP and DBP greatly increased in the Na-Hi-K-Lo group (n = 185) compared with the Na-Lo-K-Hi group (n = 185), with statistically significant BP differences at Y20, Y25, and Y30 (mean SBP, 3.93, 4.94, and 4.88 mmHg, respectively; and mean DBP, 4.70, 4.95, and 4.59 mmHg, respectively). During 25-year follow-up, among 926 participants without prevalent hypertension by Y5, 381 (41.1%) developed hypertension. In the adjusted Cox proportional hazards model, the Na-Hi-K-Lo group had hazard ratio (95% confidence interval), 1.45 (1.00-2.10) for incident hypertension compared with the Na-Lo-K-Hi group. The association with incident hypertension was predominant in blacks and white women (race--sex interaction, P = 0.03). Sodium-to-potassium ratio and sodium excretion were positively, whereas potassium excretion was inversely, associated with incident hypertension (all P trend <0.05). CONCLUSION: Our findings highlight the importance of dietary sodium reduction and higher potassium intake for hypertension prevention among young adults.

    DOI: 10.1097/HJH.0000000000002802

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  • Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis. 査読 国際誌

    Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of hypertension   Publish Ahead of Print ( 10 )   2030 - 2039   2021年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.

    DOI: 10.1097/HJH.0000000000002900

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  • Relationship between insomnia with alcohol drinking before sleep (Ne-Zake) or in the morning (Mukae-Zake) among Japanese farmers. 査読 国際誌

    Rie Sato, Takashi Hisamatsu, Hideki Tsumura, Mari Fukuda, Kaori Taniguchi, Haruo Takeshita, Hideyuki Kanda

    Alcohol (Fayetteville, N.Y.)   93   57 - 62   2021年6月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Ne-Zake is the drinking of alcohol before sleeping for helping to fall asleep and sleep well, and Mukae-Zake is the drinking of alcohol in the morning for "calming down" or "curing hangovers". OBJECTIVE: We sought to examine the relationship of insomnia with Ne-Zake and Mukae-Zake among healthy middle-aged Japanese farmers. METHODS: In a cross-sectional study of 746 participants (mean age, 59.5 years; women, 25.9%), Ne-Zake and Mukae-Zake were defined based on a self-administered questionnaire. Insomnia was defined as the Athens Insomnia Scale Japanese version ≥6 or usage of sleeping pills in the previous year. Logistic regression was used to calculate odds ratio (OR) of insomnia related to Ne-Zake and Mukae-Zake adjusting for sex, age, presence of sleep-related disorders, frequency of alcohol consumption, and quantity of alcohol consumed per one occasion. RESULTS: We observed insomnia, Ne-Zake, and Mukae-Zake in 174 (23.3%), 140 (18.8%), and 37 (5.0%) participants, respectively. After adjustment for demographic and confounding factors, participants with Ne-Zake had a significantly higher prevalence of insomnia (OR 2.00 [95% confidence interval, 1.27-3.16]), compared to those without Ne-Zake. Mukae-Zake was also independently associated with a higher prevalence of insomnia among men (OR 3.26 [1.55-6.87]). Participants with both Ne-Zake and Mukae-Zake had a highly significant association with insomnia (OR 4.77 [2.01-11.3]) than those with neither Ne-Zake nor Mukae-Zake. Additionally, for insomnia, the association of Mukae-Zake was more pronounced than that of Ne-Zake (OR 4.09, 95% CI 1.14-14.7, p = 0.031; and OR 1.81, 95% CI 1.08-3.06, p = 0.026, respectively). CONCLUSION: Ne-Zake and Mukae-Zake were associated with insomnia independent of the quantity and frequency of alcohol consumption among Japanese farmers. This finding can be used for stratifying individuals with insomnia not only to improve sleep hygiene but also to prevent alcohol dependence by informing the general population that alcohol has a negative effect on sleep, contrary to popular beliefs.

    DOI: 10.1016/j.alcohol.2020.11.005

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  • Epidemiology and control of hypertension in Japan: a comparison with Western countries 招待 査読

    Takashi Hisamatsu, Katsuyuki Miura

    Journal of Human Hypertension   2021年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s41371-021-00534-3

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    その他リンク: http://www.nature.com/articles/s41371-021-00534-3

  • Effect of Coronavirus Disease 2019 Pandemic on Physical Activity in a Rural Area of Japan: The Masuda Study. 査読

    Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Minako Kinuta, Noriko Nakahata, Hideyuki Kanda

    Journal of epidemiology   31 ( 3 )   237 - 238   2021年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.JE20200598

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  • Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines 招待 査読

    Takashi Hisamatsu, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura

    Hypertension Research   43 ( 12 )   1344 - 1351   2020年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s41440-020-0508-z

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    その他リンク: http://www.nature.com/articles/s41440-020-0508-z

  • Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years. 査読 国際誌

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    Journal of hypertension   38 ( 11 )   2230 - 2236   2020年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.

    DOI: 10.1097/HJH.0000000000002533

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  • Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. 査読 国際誌

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Sayuki Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Stroke   50 ( 10 )   2967 - 2969   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors. Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to <50%), or severe-ICAS (≥50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group. Results- The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors. Conclusions- In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.

    DOI: 10.1161/STROKEAHA.119.025964

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  • 過度の上室期外収縮と無症候性脳血管疾患との関連性 集団ベースの研究(Association between Excessive Supraventricular Ectopy and Subclinical Cerebrovascular Disease: A Population-Based Study) 査読

    Hisamatsu Takashi, Miura Katsuyuki, Fujiyoshi Akira, Kunimura Ayako, Shiino Akihiko, Nozaki Kazuhiko, Arima Hisatomi, Ohkubo Takayoshi, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   83回 ( 9 )   PE50 - 4   2019年3月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    DOI: 10.1111/ene.13970

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ene.13970

  • Coronary Artery Calcium Progression Among the US and Japanese Men. 査読

    Takashi Hisamatsu

    Circulation. Cardiovascular imaging   12 ( 2 )   2019年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

    DOI: 10.1161/circimaging.118.008104

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  • Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea 招待 査読

    Takashi Hisamatsu

    Korean Circulation Journal   49 ( 11 )   1049 - 1049   2019年1月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:The Korean Society of Cardiology  

    DOI: 10.4070/kcj.2019.0197

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  • Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds 査読 国際誌

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Hisatomi Arima, Akira Fujiyoshi, Atsushi Satoh, Aya Kadota, Maryam Zaid, Naoyuki Takashima, Seiko Ohno, Minoru Horie, Hirotsugu Ueshima

    Journal of Hypertension   36 ( 11 )   2193 - 2203   2018年11月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: The mechanism by which higher blood pressure (BP) variability causes cardiovascular events remains unclear. Experimental results indicate that alterations in vessel wall tension related to BP variability may initiate atherosclerosis through oscillatory shear stress. We examined associations of home BP variability with subclinical atherosclerosis at four anatomically distinct vascular beds. METHODS: In a cross-sectional population-based study of 1033 Japanese (mean age, 64.0 years; men, 88.7%) without known cardiovascular disease, we defined SBP and DBP variability as variability independent of the mean (VIM) across self-measured home BP values during seven consecutive days and quantified coronary and aortic artery calcification (CAC and AAC) by computed tomography, carotid intima-media thickness (CIMT) by ultrasonography, and ankle-brachial index (ABI). RESULTS: In multivariable adjusted models including mean SBP, higher VIM of SBP was associated with CIMT greater than1.0 mm [relative risk (95% confidence interval) fourth versus first quartile, 1.71 (1.15-2.54)], AAC score greater than 0 [1.08 (1.02-1.15)], and ABI less than 1.1 [1.49 (1.12-1.97)], and linear trends were also statistically significant. However, there was no significant association between VIM of SBP and CAC score greater than 0. Meanwhile, higher VIM of DBP was associated only with AAC score greater than 0. The associations were similar when modeling subclinical atherosclerosis severity as continuous outcomes and were consistent across subgroups based on demographics, behavioural, and cardiovascular risk factors. CONCLUSION: Higher variability in home BP, particularly in home SBP, was associated with greater carotid, aortic, and peripheral but not coronary atherosclerosis burdens independent of the mean home BP.

    DOI: 10.1097/hjh.0000000000001810

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  • Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study 査読

    Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    International Journal of Cardiology   267   177 - 182   2018年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. Methods and results: We performed a prospective, population-based study of Japanese men aged 40–79 years without known coronary heart disease. We measured baseline serum irisin levels using an enzyme-linked immunosorbent assay and quantified coronary artery calcification (CAC) from serial computed tomography scans. Of 1038 participants (mean age, 63.9 years) at baseline, 670 (64.6%) had prevalent CAC. Of 810 participants at follow-up (median, 5.1 years), 407 (50.3%) experienced CAC progression. In Poisson regression with robust error variance adjusted for age and behavioral factors, serum irisin levels were inversely associated with CAC prevalence (relative risk [RR] of 4th versus 1st quartiles [95% confidence interval], 0.88 [0.78–0.99]
    trend P = 0.016) and CAC progression (RR, 0.76 [0.63–0.91]
    trend P = 0.002). After further adjustment for cardiometabolic risk factors, the inverse association with CAC prevalence disappeared (RR, 0.95 [0.84–1.08]
    trend P = 0.319), but that with CAC progression persisted (RR, 0.77 [0.64–0.93]
    trend P = 0.003). These associations were consistent when we applied ordinal logistic regression and across subgroups by cardiometabolic risk factor status. Conclusions: Higher serum irisin levels were associated with less burden of coronary atherosclerosis. This association would be mediated through and beyond traditional cardiometabolic pathways.

    DOI: 10.1016/j.ijcard.2018.05.075

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  • Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study 査読

    Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    Atherosclerosis   273   145 - 152   2018年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background and aims: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). Methods: We conducted a prospective study in a population-based sample of Japanese men aged 40–79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method. Results: Of 938 participants at baseline (mean age, 63.7 ± 9.9 years), AVC prevalence was observed in 173 (18.4%). Of 596 participants without baseline AVC at follow-up (median duration, 5.1 years), AVC incidence was observed in 138 (23.2%). After adjustment for demographics, behaviors and cardiovascular risk factors, relative risks (95% confidence intervals) in the highest versus lowest categories of serum magnesium, phosphorus, and calcium were 0.62 (0.44–0.86), 1.45 (1.02–2.04), and 1.43 (0.95–2.15), respectively, for AVC prevalence and 0.62 (0.42–0.92), 1.93 (1.28–2.91), and 1.09 (0.77–1.55), respectively, for AVC incidence. Their linear trends of serum magnesium and phosphorus were also all statistically significant. Of 131 participants with baseline AVC, there was no association of any serum micronutrients with AVC progression. Conclusions: Serum magnesium was inversely associated, while serum phosphorus was positively associated with AVC prevalence and incidence, suggesting that these serum micronutrients may be potential candidates for risk prediction or prevention of CAVD, and warranting further studies.

    DOI: 10.1016/j.atherosclerosis.2018.03.035

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  • Increased Aortic Calcification Is Associated With Arterial Stiffness Progression in Multiethnic Middle-Aged Men 査読

    Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Hypertension   69 ( 1 )   102 - 108   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association of aortic calcification burden with progression of arterial stiffness in population-based samples of healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort). Men (n=635) aged 40 to 49 years (207 white American, 45 black American, 142 Japanese American, and 241 Japanese in Japan) were examined at baseline and 4 to 7 years later. Aortic calcification was evaluated from level of aortic arch to iliac bifurcation. Arterial stiffness progression was measured as annual change in brachial-ankle pulse wave velocity. Multivariable-adjusted general linear models were applied to investigate associations of longitudinal change in aortic calcification with arterial stiffness progression in participants overall, as well as in subgroups without or with prevalent aortic calcification at baseline. Annual change in aortic calcification was positively and significantly associated with arterial stiffness progression. In participants with annual changes in aortic calcium score of 0, 1 to 10, 11 to 100, and &gt;100, the adjusted means (SD) for the annual change in brachial-ankle pulse wave velocity were 3.8 (2.2), 7.2 (2.2), 12.2 (1.8), and 15.6 (2.6) cm/s, respectively (P for trend &lt;0.01) adjusted for baseline aortic calcification, arterial stiffness, and standard cardiovascular risk factors. Arterial stiffness was associated with the incidence of aortic calcification over the follow-up period among participants without aortic calcification (n=297) and with an increase in aortic calcification among participants with prevalent aortic calcification at baseline (n=388). Our findings suggest aortic calcification may be causally linked to arterial stiffness.

    DOI: 10.1161/HYPERTENSIONAHA.116.08459

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  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA) 査読

    久松隆史, 久松隆史, 三浦克之, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 柳田昌彦, 前川聡, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017年

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    【背景】客観的に評価された身体活動量がメタボリックシンドローム(MetS)発症リスクと関連するかどうか検討した研究はほとんどない。【目的】日本人一般住民男性において、歩数計を用いて評価された歩数値とMetS新規発症との関連を縦断的に検討すること。【方法】滋賀県草津市住民から無作為抽出された40-79歳男性のうちMetSを有さない525名(平均年齢64.1±9.6歳)を対象とし、5年間の前向きコホート研究(基礎調査2006-8年)を実施した。歩数は基礎調査時に土・日曜日を含む7日間連続で歩数計を用いて測定し1日平均値を求めた。MetS発症の診断は日本基準を用いて評価した。ロジスティック回帰を用いてMetS新規発症に対する歩数値に関する多変量調整相対リスク(RR)および95%信頼区間(CI)を算出した。【結果】平均追跡期間4.8±1.3年を経て、MetS新規発症者は77名(14.7%)であった。Body mass indexを含む交絡因子を調整後も歩数値とMetS発症との間に負の関連を認めた。この関連はMetS各構成要素でさらに調整しても変わらなかった(最低三分位群[5,792歩未満]と比較して、最高三分位群[10,033歩以上]のMetS発症に対するRR(95%CI)は0.34[0.17-0.72])。また、MetS発症に対する1日平均1,000歩増加あたりのRR(95%CI)は、0.87(0.78-0.96)であった。65歳未満・以上、MetS各構成要素の有無で層別に解析したが同様の傾向を認めた(全異質性P値>0.3)。【結語】MetSの好発集団とされる一般中高年男性において、客観的に評価された歩数値はMetS発症と有意な負の関連を示した。また、1日平均歩数値1,000歩増加あたりMetS発症リスクが13%低下した。本成果は健康日本21(第二次)の歩数目標値や身体活動基準2013を支持する結果である。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J03571&link_issn=&doc_id=20170329310003&doc_link_id=%2Fcs3cardi%2F2017%2F005201%2F003%2F0020-0028%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcs3cardi%2F2017%2F005201%2F003%2F0020-0028%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men 査読

    Hisamatsu Takashi, Miura Katsuyuki, Arima Hisatomi, Kadota Aya, Kadowaki Sayaka, Torii Sayuki, Suzuki Sentaro, Miyagawa Naoko, Sato Atsushi, Yamazoe Masahiro, Fujiyoshi Akira, Ohkubo Takayoshi, Yamamoto Takashi, Murata Kiyoshi, Robert D. Abbott, Sekikawa Akira, Horie Minoru, Ueshima Hirotsugu, the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

    Journal of the American Heart Association   5 ( 9 )   e003738   2016年8月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Heart Association ; American Stroke Association  

    BACKGROUND: Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia.METHODS AND RESULTS: In a population-based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross-sectional associations of smoking status, cumulative pack-years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima-media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle-brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16-2.79]; CIMT >1.0 mm, 1.88 [1.02-3.47]; AoAC >0, 4.29 [2.30-7.97]; and ankle-brachial index <1.1, 1.78 [1.16-2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13-3.34]; and AoAC >0, 2.55 [1.45-4.49]). Dose-response relationships of pack-years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle-brachial index, were observed among both current and former smokers, and even a small amount of pack-years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices.CONCLUSIONS: Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation.

    DOI: 10.1161/jaha.116.003738

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  • Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components 査読 国際誌

    Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima

    Arteriosclerosis, Thrombosis, and Vascular Biology   36 ( 8 )   1703 - 1708   2016年8月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: The association between insulin resistance (IR) and coronary artery calcification (CAC) has been uncertain after adjustment for metabolic syndrome components. We aimed to evaluate whether IR is associated with CAC prevalence or progression independently of metabolic syndrome components. APPROACH AND RESULTS: We conducted a population-based study in a random sample of Japanese men aged 40 to 79 years and determined IR using the homeostasis model assessment of insulin resistance (HOMA-IR). The associations of HOMA-IR and other diabetic parameters per 1-SD increase with CAC prevalence and progression were evaluated using multivariable logistic regression. Of 1006 total participants at baseline (mean age, 64±10 years), CAC prevalence was observed in 646 (64.2%), and of 789 participants at follow-up (mean duration, 4.9±1.3 years), CAC progression was observed in 365 (46.3%). After adjustment for covariates including metabolic syndrome components, higher HOMA-IR was independently associated with CAC prevalence (adjusted odds ratio 1.34, 95% confidence interval 1.10-1.63; P=0.003) and progression (odds ratio 1.32, 95% confidence interval 1.09-1.60; P=0.004). In participants without diabetes mellitus, positive associations were similarly observed (prevalence: odds ratio 1.29, 95% confidence interval 1.04-1.60; P=0.022; and progression: odds ratio 1.25, 95% confidence interval 1.01-1.55; P=0.042), whereas glucose and hemoglobin A1c were not associated with CAC prevalence and progression. CONCLUSIONS: Higher IR was associated with CAC prevalence and progression independently of metabolic syndrome components in Japanese men and also in those without diabetes mellitus. Among diabetic measures, IR and fasting insulin, but not glucose and hemoglobin A1c, predicted CAC progression in men without diabetes mellitus.

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  • Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population 査読 国際誌

    Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

    Atherosclerosis   236 ( 2 )   237 - 243   2014年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    OBJECTIVE: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. METHODS AND RESULTS: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. CONCLUSIONS: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids.

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  • High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population 査読

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF CARDIOLOGY   64 ( 3-4 )   218 - 224   2014年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: Increased resting heart rate (RHR) independently predicts cardiovascular mortality. Meanwhile, long-chain n-3 fatty acids (LCn3FAs) have a cardioprotective effect. Our aim was to evaluate whether higher LCn3FAs intake attenuates the elevated risk of cardiovascular mortality associated with increased RHR.
    Methods: We conducted a population-based 24-year prospective cohort study of Japanese, whose LCn3FAs intake is relatively high. Study participants included 8807 individuals aged 30-95 years from randomly selected areas across Japan without cardiovascular diseases and anti-hypertensive drugs at baseline. The primary endpoint was cardiovascular mortality, and the secondary endpoints were cardiac and stroke mortality during 24 years of follow-up. Individual dietary LCn3FAs intake was estimated from household-based 3-day weighed food records. RHR was obtained from 3 consecutive R-wave intervals on 12-lead electrocardiography. Cox models were used to estimate the multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) adjusting for possible confounders.
    Results: During the follow-up period, 617 cardiovascular deaths were observed. The median daily intake of LCn3FAs was 0.37% kcal (0.86 g/day). The interaction between dietary LCn3FAs intake and RHR in the risk of cardiovascular mortality was statistically significant (p = 0.033). The risk of cardiovascular mortality was significantly higher in the low-intake group (&lt;0.37% kcal) with an RHR &gt;85 beats/min (bpm) [hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.15-2.43], but not in the high-intake group (&gt;= 0.37% kcal) with an RHR &gt;85 bpm (HR, 0.92; 95% CI, 0.61-1.38), compared with those in the high-intake group with an RHR &lt;70 bpm. Similar results were observed with stroke mortality, but not with cardiac mortality.
    Conclusions: The risk of cardiovascular mortality associated with increased RHR is elevated in participants with low dietary LCn3FAs intake, but not in participants with high dietary LCn3FAs intake in a representative Japanese general population. These results suggest that high dietary LCn3FAs intake may prevent cardiovascular mortality associated with increased RHR. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jjcc.2014.01.005

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  • Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men 査読

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    Heart   99 ( 14 )   1024 - 1029   2013年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    Objective Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) &gt;= 0.1 mV on electrocardiography.
    Design A prospective population-based cohort study.
    Setting The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan.
    Participants A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan.
    Main outcome measures Cardiac death (200 men) during the 24-year follow-up.
    Results Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35% kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (&lt;0.35% kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p&lt;0.001), but not in the high intake group (&gt;= 0.35% kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006).
    Conclusions The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.

    DOI: 10.1136/heartjnl-2012-303496

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  • Association between J-Point elevation and death from coronary artery disease 査読

    Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, for the NIPPON DATA, Research Group

    Circ J.   77 ( 5 )   1260 - 1266   2013年

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  • Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis. 国際誌

    Thien Vu, Yuichiro Yano, Huy Kien Tai Pham, Rajib Mondal, Mizuki Ohashi, Kaori Kitaoka, Mohammad Moniruzzaman, Sayuki Torii, Akihiko Shiino, Atsushi Tsuji, Takashi Hisamatsu, Tomonori Okamura, Keiko Kondo, Aya Kadota, Yoshiyuki Watanabe, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Scientific reports   14 ( 1 )   10765 - 10765   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5 T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to < 50%) and severe-ICAS (≥ 50%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance "low LDL-c-high LDL-p" group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55-5.00) in the reference of the concordance "low LDL-c-low LDL-p" group. This was followed by the concordance "high LDL-c-high LDL-p" group of 2.56 (1.69-3.85) and the discordance "high LDL-c-low LDL-p" group of 2.40 (1.29-4.46). These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.

    DOI: 10.1038/s41598-024-59523-4

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  • Heart Rate Fragmentation, Ambulatory Blood Pressure, and Coronary Artery Calcification: A Population-Based Study. 査読 国際誌

    Yuichi Sawayama, Yuichiro Yano, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Sayuki Torii, Keiko Kondo, Sayaka Kadowaki, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

    JACC. Asia   4 ( 3 )   216 - 225   2024年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Little is known regarding whether ultra-rapid patterns of heart rate variability (eg, heart rate fragmentation [HRF]) are associated with coronary artery calcification (CAC) in a general population. OBJECTIVES: This study aimed to assess the association between HRF and CAC, and whether these associations are independent of systolic blood pressure (SBP) levels. METHODS: From SESSA (the Shiga Epidemiological Study of Subclinical Atherosclerosis), we used data from 24-hour ambulatory blood pressure monitoring to identify awake and asleep SBP levels, and data from concurrent 24-hour Holter monitoring to quantify HRF using the awake and asleep percentage of inflection points (PIP). CAC on computed tomography scanning was quantified using an Agatston score. We used multivariable binomial logistic regression to assess the associations of PIP and ambulatory SBP with the presence of CAC, as defined by Agatston score >0. RESULTS: Of the 508 participants in this study (mean age: 66.5 ± 7.3 years), 325 (64%) had CAC and 183 (36%) did not. In fully adjusted models of prevalent CAC that also included office SBP, the ORs with 95% CIs for awake PIP, awake SBP, asleep PIP, and asleep SBP were 1.23 (95% CI: 0.99-1.54), 1.40 (95% CI: 1.11-1.77), 1.31 (95% CI: 1.05-1.62), and 1.28 (95% CI: 1.02-1.60), respectively. There was no evidence of interaction between PIP and ambulatory SBP in association with CAC. Results were similar when other HRF indices instead of PIP were used. CONCLUSIONS: Higher HRF and SBP levels during sleep are each associated with the presence of CAC in a general male population.

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  • Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population - NIPPON DATA90. 査読

    Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura

    Circulation journal : official journal of the Japanese Circulation Society   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Deviations of hemoglobin from normal levels may be a factor in cardiovascular disease (CVD) risk; however, conclusive evidence is lacking. In addition, preclinical conditions may influence hemoglobin concentrations, but studies focusing on reverse causation are limited. Thus, we examined the relationship between hemoglobin concentrations and CVD mortality risk, considering reverse causation.Methods and Results: In a prospective cohort representative of the general Japanese population (1990-2015), we studied 7,217 individuals (mean age 52.3 years; 4,219 women) without clinical CVD at baseline. Participants were categorized into sex-specific hemoglobin quintiles (Q1-Q5) and data were analyzed using the Cox proportional hazards model adjusted for possible confounders. During a 25-year follow-up, 272 men and 334 women died from CVD. Adjusted hazard ratios for CVD mortality across sex-specific quintiles, using Q3 as the reference, were significantly higher for Q1 (1.40; 95% confidence interval [CI] 1.08-1.82) and Q5 (1.49; 95% CI 1.14-1.96), and remained significant after excluding deaths within the first 5 years of follow-up to consider reverse causation (1.35 [95% CI 1.02-1.79] and 1.45 [95% CI 1.09-1.94], respectively). A similar U-shaped association was seen between transferrin saturation levels and CVD mortality, but after excluding deaths within the first 5 years the association was significant only for Q1. CONCLUSIONS: Low and high hemoglobin concentrations were associated with an increased risk of CVD mortality.

    DOI: 10.1253/circj.CJ-23-0725

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  • Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men. 査読 国際誌

    Takeshi Shibukawa, Akira Fujiyoshi, Mohammad Moniruzzaman, Naoko Miyagawa, Aya Kadota, Keiko Kondo, Yoshino Saito, Sayaka Kadowaki, Takashi Hisamatsu, Yuichiro Yano, Hisatomi Arima, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

    Preventive medicine reports   38   102615 - 102615   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective measure of physical activity, and cognitive function in community-based middle-aged and older Japanese men. METHODS: The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited community-dwelling healthy men aged 40-79 years from Shiga, Japan, and measured their step counts over 7 consecutive days using a pedometer at baseline (2006-2008). Among men who returned for follow-up (2009-2014), we assessed their cognitive function using the Cognitive Abilities Screening Instrument (CASI) score. We restricted our analyses to those with valid 7-day average step counts at baseline and those who remained free of stroke at follow-up (n = 676). Using analysis of covariance, we calculated the adjusted means of the CASI score according to the quartiles of the average step counts. RESULTS: The mean (standard deviation) of age and unadjusted CASI score were 63.8 (9.1) years and 90.8 (5.8), respectively. The CASI score was elevated in higher quartiles of step counts (90.2, 90.4, 90.6, and 91.8 from the lowest to the highest quartile, respectively, [p for trend = 0.004]) in a model adjusted for age and education. Further adjustment for smoking, drinking, and other cardiovascular risk factors resulted in a similar pattern of association (p for trend = 0.005). CONCLUSION: In apparently healthy middle-aged and older Japanese men, a greater 7-day average step count at baseline was associated with significantly higher cognitive function score.

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  • High blood pressure in childhood and adolescence. 招待 査読 国際誌

    Takashi Hisamatsu, Minako Kinuta

    Hypertension research : official journal of the Japanese Society of Hypertension   47 ( 1 )   203 - 205   2023年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1038/s41440-023-01488-4

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  • The gut microbiota and coronary artery calcification in Japanese men. 査読 国際誌

    Yukiko Okami, Hisatomi Arima, Keiko Kondo, Zhang Hexun, Yuichiro Yano, Aya Kadota, Sayuki Torii, Takashi Hisamatsu, Akira Fujiyoshi, Sayaka Kadowaki, Yoshiyuki Watanabe, Akira Andoh, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura for the SESSA Research Group

    American heart journal   267   12 - 21   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota associated with subclinical coronary artery calcification (CAC) in a Japanese population. METHODS: A total of 663 Japanese men were enrolled in this cross-sectional study. Computed tomography and gut microbiology tests were performed, and CAC scores were calculated using the Agatston method. Participants were categorized into four groups based on their CAC scores: CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history. The bacterial 16S ribosomal RNA gene was amplified, and DNA sequencing was conducted on a MiSeq System. QIIME2 and LEfSe were used to analyze the gut microbiota, and the results obtained were compared among the four CAC categories. RESULTS: The mean age of participants was 68.4 years (46-83 years). The numbers of participants in CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history were 219, 200, 193, and 51, respectively. The medians of the Firmicutes to Bacteroidota ratio were 1.50, 1.52, 1.67, and 1.80 for each CAC category (P = 0.020). One standard deviation higher phylum Firmicutes, class Bacilli, and order Lactobacillales were associated with a 1.3- to 1.4-fold higher risk of CAD. These taxa were also associated with a higher CAC score category. The family Streptococcaceae and genus Streptococcus showed a higher risk of CAD. The order Enterobacterales and family Enterobacteriaceae correlated with CAC scores. The genus Blautia showed a preventive direction for CAD, but did not correlate with CAC scores. CONCLUSIONS: The gut microbiota significantly differed from the phylum to genus level in a manner that was dependent on CAC scores, even before the onset of CAD.

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  • Long-Term Effect of Smoking Ban Legislation on Hospitalization for Acute Coronary Syndrome. 招待 査読

    Takashi Hisamatsu, Minako Kinuta

    Circulation journal : official journal of the Japanese Circulation Society   87 ( 11 )   1686 - 1688   2023年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • At-risk internet addiction and related factors among senior high school teachers in Japan based on a Nationwide survey. 査読 国際誌

    Mari Fukuda, Mohammad Chowdhury, Tanvir Turin Chowdhury, Hideki Tsumura, Rina Tsuchie, Minako Kinuta, Takashi Hisamatsu, Hideyuki Kanda

    Neuropsychopharmacology reports   43 ( 4 )   553 - 560   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Internet addiction (IA) has been drawing attention to mental health. However, few reports have been found on the related factors of at-risk IA among regular workers by a nationwide survey. The study aimed to evaluate the characteristics of at-risk IA and identify related factors among senior high school teachers in Japan. METHODS: This survey was a cross-sectional survey of high schools across Japan in 2017. There were 3189 teachers (2088 males and 1098 female) who participated in this survey. The questionnaire asked about their devices, both the time and the activities of using their internet, and sociodemographic factors. IA was measured by the internet addiction test (IAT) by which 40-79 points were classified as at-risk IA, and more as IA. We compared the related factors of at-risk IA and non-IA using descriptive analysis and multivariable regression analysis. RESULTS: The rates of IA and at-risk IA were 0.09% (n = 3) and 6.91% (n = 220), respectively. At-risk IA was positively associated with activities on the internet for gaming, entertainment, net-surfing, and younger ages. In addition, the at-risk IA group had a longer time spent on the internet than the non-IA group. CONCLUSIONS: Around 7% of high school teachers are at-risk IA in this survey, though they have regular work. Our results suggest that at-risk IA may be reinforced not only by the active internet use such as gaming, but also by purposeless behaviors, such as net-surfing. Managing time on the internet may support preventing at-risk IA among senior high school teachers.

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  • Relationships of rapid eating with visceral and subcutaneous fat mass and plasma adiponectin concentration. 査読 国際誌

    Hideki Tsumura, Mari Fukuda, Takashi Hisamatsu, Rie Sato, Rina Tsuchie, Hideyuki Kanda

    Scientific reports   13 ( 1 )   11491 - 11491   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Rapid eating has been demonstrated to be associated with obesity and overweight. However, few studies have characterized the separate relationships of eating speed with visceral and subcutaneous fat mass or circulating adiponectin concentration. We hypothesized that rapid eating is associated with the larger visceral fat tissue (VFT) area and lower adiponectin concentration, but not with the subcutaneous fat tissue (SFT) area in men and women. We performed a cross-sectional study of 712 adults aged 20-86 years (528 men and 184 women; mean ± SD age 59.36 ± 13.61 years). The participants completed a self-reported questionnaire, and underwent anthropometric and laboratory measurements and computed tomographic imaging of the abdomen as a part of annual medical check-ups. Multivariate linear regression analyses revealed that rapid eating was associated with larger visceral (B = 24.74; 95% CI 8.87-40.61, p = 0.002) and subcutaneous fat areas (B = 31.31; 95% CI 12.23-50.38, p = 0.001), lower adiponectin concentration (B =  - 2.92; 95% CI - 4.39- - 1.46, p < 0.001), higher body mass index (BMI) (B = 2.13; 95% CI 1.02-3.25, p < 0.001), and larger waist circumference (B = 5.23; 95% CI 2.16-8.30, p < 0.001) in men, which is partially consistent with the hypothesis. In contrast, rapid eating was found to be associated only with BMI, and not with abdominal adipose area or adiponectin concentration in women, which is a result that is not consistent with the hypothesis. These results suggest that there is no difference in the association of rapid eating with VFT and SFT areas.

    DOI: 10.1038/s41598-023-38623-7

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  • Coronary Artery Calcium in Assessment of Atherosclerotic Cardiovascular Disease Risk and its Role in Primary Prevention. 招待 査読

    Takashi Hisamatsu, Minako Kinuta

    Journal of atherosclerosis and thrombosis   30 ( 10 )   1289 - 1302   2023年7月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Coronary artery calcium (CAC), which is detected using computed tomography scanning, is a well-established indicator of subclinical atherosclerosis. The CAC score is independently associated with atherosclerotic cardiovascular disease (ASCVD) outcomes and provides improved predictive values for estimating the risk of ASCVD beyond traditional risk factors. Thus, CAC is considered to have important implications for reclassification as a decision aid among individuals in the preclinical phase and as the primary prevention of ASCVD. This review is focused on epidemiological evidence on CAC in asymptomatic population-based samples from Western countries and Japan. We also discuss the usability of CAC as a tool for assessing ASCVD risk and its role in the primary prevention of ASCVD. A lack of evidence for the CAC score in ASCVD risk assessment beyond traditional risk factors in populations other than those in Western countries (including Japan) warrants further investigation. Clinical trials are also necessary to demonstrate the usefulness and safety of CAC screening in the primary prevention of ASCVD.

    DOI: 10.5551/jat.RV22009

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  • Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men. 査読 国際誌

    Nazar M Azahar, Yuichiro Yano, Aya Kadota, Akihiko Shiino, Ali H Syaifullah, Naoko Miyagawa, Keiko Kondo, Mohammad Moniruzzaman, Sayuki Torii, Hiroyoshi Segawa, Takashi Hisamatsu, Akira Fujiyoshi, Kazuhiko Nozaki, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of the American Heart Association   12 ( 11 )   e028586   2023年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations with brain could provide insights into the mechanisms of brain structural changes. Methods and Results Using data from the SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis), we analyzed data among 686 Japanese men (mean [SD] age, 67.9 [8.4] years; range, 46-83 years) free from history of stroke and myocardial infarction. Brachial-ankle pulse wave velocity and coronary artery calcification on computed tomography scans were measured between March 2010 and August 2014. Brain volumes (total brain volume, gray matter, Alzheimer disease signature and prefrontal) and brain vascular damage (white matter hyperintensities) were quantified using brain magnetic resonance imaging from January 2012 through February 2015. In multivariable adjustment models including mean arterial pressure, when brachial-ankle pulse wave velocity and coronary artery calcification were entered into the same models, the β (95% CI) for Alzheimer disease signature volume for each 1-SD increase in brachial-ankle pulse wave velocity was -0.33 (-0.64 to -0.02), and the unstandardized β (95% CI) for white matter hyperintensities for each 1-unit increase in coronary artery calcification was 0.68 (0.05-1.32). Brachial-ankle pulse wave velocity and coronary artery calcification were not statistically significantly associated with total brain and gray matter volumes. Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.

    DOI: 10.1161/JAHA.122.028586

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  • Mendelian Randomization to Evaluate the Causal Effect of Serum Bilirubin on Atrial Fibrillation. 招待 査読 国際誌

    Takashi Hisamatsu

    Korean circulation journal   53 ( 7 )   480 - 482   2023年5月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:英語  

    DOI: 10.4070/kcj.2023.0075

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  • Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome. 査読 国際誌

    Takanori Aizawa, Yuko Wada, Kanae Hasegawa, Hai Huang, Tomohiko Imamura, Jingshan Gao, Asami Kashiwa, Hirohiko Kohjitani, Megumi Fukuyama, Koichi Kato, Eri Toda Kato, Takashi Hisamatsu, Seiko Ohno, Takeru Makiyama, Takeshi Kimura, Minoru Horie

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   25 ( 4 )   1491 - 1499   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. METHODS AND RESULTS: We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants-whether they cause HI or DN via altered functional domains-and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). CONCLUSION: Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2.

    DOI: 10.1093/europace/euac269

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  • Association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and subclinical cerebrovascular disease in the community. 査読 国際誌

    Ayako Kunimura, Yuichiro Yano, Takashi Hisamatsu, Sayuki Torii, Keiko Kondo, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    European journal of neurology   30 ( 5 )   1327 - 1334   2023年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low-density lipoprotein cholesterol (LDL-C) and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 levels have been poorly elucidated in the general population, particularly in association with subclinical cerebrovascular disease including cerebral small vessel disease (CSVD) and intracranial artery stenosis (ICAS). METHODS: In community-dwelling Japanese men (n = 526) aged 46-82 years without a history of cardiovascular disease, we assessed the associations of serum PCSK9 levels with the prevalence of CSVD and ICAS using magnetic resonance imaging. CSVD included lacunar infarction, deep and subcortical white matter hyperintensity, periventricular hyperintensity, and cerebral microbleeds. RESULTS: The median (interquartile range) age at baseline and serum PCSK9 levels were 69 (63 - 74) years and 240 (205-291) ng/mL, respectively. After adjusting for traditional cardiovascular risk factors including LDL-C, multivariable Poisson regression with robust error variance revealed a significant association between PCSK9 levels (per 1-SD) and ICAS (relative risks 1.18, 95% confidence intervals [CI] 1.02-1.37). Multivariable ordinal logistic regression for ICAS, with stenosis graded as mild (<50%) or moderate-severe (≥50%), revealed a similar association (common odds ratio 1.31, 95% CI 1.04-1.64). However, no significant association was observed between serum PCSK9 levels and CSVD. CONCLUSIONS: Higher circulating PCSK9 levels were independently associated with a ICAS prevalence but not with a CSVD prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population.

    DOI: 10.1111/ene.15723

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  • Association and dose-response relationship between exposure to alcohol advertising media and current drinking: a nationwide cross-sectional study of Japanese adolescents. 査読

    Keita Yoshida, Hideyuki Kanda, Takashi Hisamatsu, Yuki Kuwabara, Aya Kinjo, Hisashi Yoshimoto, Teruna Ito, Hideaki Kasuga, Ruriko Minobe, Hitoshi Maesato, Maki Jike, Yuuki Matsumoto, Yuichiro Otsuka, Osamu Itani, Yoshitaka Kaneita, Susumu Higuchi, Yoneatsu Osaki

    Environmental health and preventive medicine   28   58 - 58   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Underage drinking is a public health concern. However, few studies have examined the association between alcoholic beverage advertising and underage drinking, particularly in countries with low underage drinking rates, such as Japan. Therefore, we aimed to investigate the relationship between exposure to advertising in various media and alcohol drinking among Japanese adolescents. METHODS: We conducted a cross-sectional study involving 15,683 adolescents (51% girls) using data from a nationwide lifestyle survey in 2021 among junior and senior high schools across Japan. Media types were websites, stores, and public transportation. We defined current drinking as alcohol consumption of ≥1 day in the 30 days preceding the survey. Multivariable logistic regression was used to examine the association between exposure to alcohol advertisements and current drinking, adjusting for sex, grades, school area, lifestyle (bedtime and having fun at school), and addictive behaviors (smoking status and parents' alcohol consumption). RESULTS: The prevalence of current drinking was 2.2% (2.3% of boys and 2.0% of girls). Students who were exposed to any alcohol advertising media had higher odds of current drinking compared with those who were not (odds ratio, 1.48; 95% confidence interval [CI], 1.18-1.87). Students who were exposed to web, in-store, and public transportation advertisements had odds ratios of 1.44 (95% CI, 1.14-1.81), 1.62 (1.28-2.05), and 1.45 (1.06-1.98) of current drinking, respectively, compared with those who were not. The association of exposure to alcohol advertising media with the prevalence of current drinking was similar among boys and girls (all p for sex interaction >0.1), except for that of exposure to web advertisements; its association with current drinking was more pronounced in girls (p for sex interaction = 0.046). Exposure to a larger cumulative number of different alcohol advertising media was independently associated with a higher prevalence of current drinking among all students, boys, and girls (p-values for trend <0.001, 0.031, and <0.001, respectively; p for sex interaction = 0.085). CONCLUSIONS: We found an association with a dose-response relationship between exposure to alcohol advertisements and current drinking among adolescents in junior and senior high schools across Japan. Our findings highlight the need for further advertising regulations to prevent underage drinking.

    DOI: 10.1265/ehpm.23-00127

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  • Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40-79 years. 査読 国際誌

    Xiao Zhang, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Sayuki Torii, Yukiko Okami, Takashi Hisamatsu, Yuichiro Yano, Emma Barinas-Mitchell, Jared Magnani, Katsuyuki Miura, Hirotsugu Ueshima, Akira Sekikawa

    Scientific reports   12 ( 1 )   20114 - 20114   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Equol is an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed equol-producers (EP). Equol might be the critical anti-atherogenic component of ISFs. In a population-based study of 979 Japanese men aged 40-79 without cardiovascular (CVD) or chronic kidney disease, we measured the urinary levels of equol and ISFs. Aortic calcification (AC) in the entire aorta was assessed by electron-beam or multi-detector-row computed tomography. Subjects with log10 (urinary equol to daidzein concentration) > - 1.5 were classified as EP. EP was further classified as person with low- and high-equol. We analyzed the association between equol-producing status and AC presence, defined as AC score > 0, by the logistic regressions. We found that EP (50% of the sample) had significantly lower odds of AC presence (odds ratio (OR): 0.62, 95% confidence interval (CI): 0.39, 0.98) compared to non-EP. This association was independent of CVD risk factors. For the dose-response association, compared to non-EP, subjects with low and high levels of equol had ORs of 0.51 (95% CI 0.30, 0.84) and 0.67 (95% CI 0.39, 1.14) after adjusting for major CVD risk factors (p for trend = 0.06). ISFs concentrations were not significantly associated with AC presence (OR: 1.18, 95% CI: 0.82, 1.69). In conclusion, EP had a significantly lower burden of AC than non-EP, while ISFs were not associated with AC presence in Japanese men aged 40-79 years.

    DOI: 10.1038/s41598-022-24659-8

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  • Association between serum irisin levels and MRI-measureed cerebral small vessel disease in Japanese men 査読

    Moniruzzaman M, Kadota A, Hisamatsu T, Segawa H, Kondo K, Torii S, Miyagawa N, Fujiyoshi A, Yano Y, Watanabe Y, Shiino A, Nozaki A, Ueshima H, Miura K

    30 ( 8 )   1045 - 1056   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.63824

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  • Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men. 査読

    Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   30 ( 7 )   767 - 777   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on atherosclerotic plaque formation in the general population remains unknown. We assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population. METHODS: Community-dwelling Japanese men (n=622) aged 46-82 years without a history of cardiovascular disease and lipid-lowering medications were included. Serum PCSK9 concentration and CAC score were measured using the Agatston method, and the multivariable analysis was used to assess their association. CAC was defined as an Agatston score of >10. We conducted further analysis stratified by age (<60, 60-69, and ≥ 70 years). RESULTS: The average age, LDL-C, and median serum PCSK9 concentration were 68 years, 122 mg/dL, and 240 ng/mL, respectively. After multivariable adjustment for traditional cardiovascular risk factors, no significant association was observed between serum PCSK9 concentration and CAC prevalence (adjusted relative risk [aRR] 1.05, 95% confidence interval [CI] 0.97-1.13). With age stratification, serum PCSK9 concentration was significantly associated with CAC prevalence in men aged <60 years (aRR 1.38, 95% CI 1.01-1.88) but not in men aged 60-69 years (aRR 0.96, 95% CI 0.85-1.10) or ≥ 70 years (aRR 1.08, 95% CI 0.99-1.19). CONCLUSIONS: A higher serum PCSK9 concentration was associated with a higher CAC prevalence in men aged <60 years, which was independent of traditional cardiovascular risk factors.

    DOI: 10.5551/jat.63549

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  • Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90). 査読 国際誌

    Kota Kubo, Tomonori Okamura, Daisuke Sugiyama, Takashi Hisamatsu, Aya Hirata, Aya Kadota, Keiko Kondo, Takumi Hirata, Aya Higashiyama, Takehito Hayakawa, Yoshihiro Miyamoto, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

    The American journal of cardiology   184   1 - 6   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The relation between chronic kidney disease (CKD) and cardiovascular disease (CVD) in the general population is well elucidated. In patients with CKD, anemia is associated with adverse outcomes. However, the effects of CKD and anemia on CVD in the general population remains poorly explored, especially in Asian populations. This study aimed to investigate the effect of CKD and/or anemia on CVD mortality in a long-term cohort study involving Japanese community dwellers. We assessed 7,339 participants (aged ≥30 years) with no CVD history. These participants were divided into 4 categories according to their CKD (estimated glomerular filtration rate <60 or urine protein >1+ by dipstick qualitative test) and/or anemia (hemoglobin: <13 g/100 ml [men], <12 g/100 ml [women]) statuses. For each category, we calculated the hazard ratios (HRs) of CVD mortality by using the Cox proportional hazards model after adjusting for age, body mass index, hypertension, diabetes, dyslipidemia, smoking, and alcohol drinking. Within 25 years of follow-up, 637 participants died because of CVD. The HRs of CVD in patients with CKD only, anemia only, and both were 1.27, 1.59, and 2.60 (95% confidence intervals [CI] 1.06 to 1.53, 1.34 to 1.90, and 1.80 to 3.76) in men and 1.42, 1.08, and 2.00 (95% CI 1.19 to 1.69, 0.99 to 1.18, and 1.54 to 2.60) in women, respectively. In conclusion, CKD with anemia is associated with an increased risk for CVD mortality in a general population in Japan.

    DOI: 10.1016/j.amjcard.2022.08.027

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  • Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men. 査読 国際誌

    Keiko Kondo, Hisatomi Arima, Akira Fujiyoshi, Akira Sekikawa, Aya Kadota, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Katsutaro Morino, Naoko Miyagawa, Hiroyoshi Segawa, Yoshiyuki Watanabe, Hiroshi Maegawa, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Cerebrovascular diseases (Basel, Switzerland)   51 ( 6 )   1 - 7   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. METHODS: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. RESULTS: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. CONCLUSIONS: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.

    DOI: 10.1159/000524243

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  • Premature Atrial Contractions and Their Determinants in a General Population of Japanese Men. 査読

    Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 8 )   1298 - 1306   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本循環器学会  

    BACKGROUND: Premature atrial contractions (PACs) are predictors of atrial fibrillation, stroke, and cardiovascular mortality. The present study aimed to assess relevant factors for PACs among a general population of Japanese men.Methods and Results:This study conducted a population-based, cross-sectional study among 517 men, aged 40-79 years, with neither apparent myocardial infarction nor atrial fibrillation. 24-h Holter electrocardiography to assess PAC frequency was used. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, mean heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy were included in multivariable negative binomial regression analyses to assess correlation for the number of PACs per hour. Almost all participants (99%) had at least 1 PAC in 1 h (median number 2.84 PACs per h). In multivariable negative binomial regression after adjusting for all covariates simultaneously, age (relative risk [95% confidence interval], 1.30 [1.08-1.57] per 1-standard deviation [SD] increment), height (1.19 [1.02-1.39] per 1-SD increment), triglycerides (0.79 [0.65-0.97] per 1-SD increment), mean heart rate (0.69 [0.59-0.80] per 1-SD increment), physical activity (0.63 [0.43-0.93]), current smoking (1.69 [1.06-2.69]), current moderate (1.97 [1.23-3.16]) and heavy (1.84 [1.12-3.01]) alcohol consumption were independently associated with PAC frequency. CONCLUSIONS: PAC frequency was independently associated with age, height, smoking, alcohol consumption, heart rate, physical activity, and triglycerides.

    DOI: 10.1253/circj.CJ-21-0872

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    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J04756&link_issn=&doc_id=20220817400013&doc_link_id=10.1253%2Fcircj.CJ-21-0872&url=https%3A%2F%2Fdoi.org%2F10.1253%2Fcircj.CJ-21-0872&type=Crossref&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00002_2.gif

  • Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification 査読

    Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shinichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa, Ebtehal Salman, Itsuko Miyazawa, Takashi Yamamoto, Yoshihisa Nakagawa, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   29 ( 9 )   1359 - 1371   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    AIMS: The roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression. METHODS: A total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of >10 Agatston units (AU) among men with 0<CAC<100 AU at baseline, that of >10% among those with CAC ≥ 100 AU, and any progression for those with CAC=0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model. RESULTS: The mean follow-up period was 4.9 years. CAC progression was detected in 45.8% of participants. Positive associations between CAC progression and albuminuria (>30mg/g) (RR: 1.29; 1.09 to 1.53; p=0.004) and low eGFRcys (<60ml/min/1.73m2) (RR: 1.27; 1.05 to 1.53; p=0.012) remained significant after adjustments for age, the follow-up time, and computerized tomography type. Following further adjustments for hypertension, diabetes mellitus, dyslipidemia, C-reactive protein, and lifestyle factors, CAC progression was associated with albuminuria (RR: 1.20; 1.01 to 1.43; p=0.04) and low eGFRcys (RR: 1.19; 0.99 to 1.43; p=0.066), but not with eGFRcre. CONCLUSION: CAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.

    DOI: 10.5551/jat.63030

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  • Prologue: Special Spotlight Issue on Japan 招待 査読 国際誌

    Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario

    Journal of Human Hypertension   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s41371-021-00589-2

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  • Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men(和訳中) 査読

    Vu Thien, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Zaid Maryam, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Nakagawa Yoshihisa, Suzuki Tomoaki, Asai Tohru, Miura Katsuyuki, Ueshima Hirotsugu

    Circulation Journal   85 ( 7 )   1076 - 1082   2021年6月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    BACKGROUND: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. CONCLUSIONS: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.

    DOI: 10.1253/circj.CJ-20-1090

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04756&link_issn=&doc_id=20210702370016&doc_link_id=10.1253%2Fcircj.CJ-20-1090&url=https%3A%2F%2Fdoi.org%2F10.1253%2Fcircj.CJ-20-1090&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Apolipoprotein A2 Isoforms: New Insight into the Risk of Myocardial Infarction 招待 査読

    Takashi Hisamatsu

    Journal of Atherosclerosis and Thrombosis   28 ( 5 )   469 - 470   2021年5月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:英語   出版者・発行元:Japan Atherosclerosis Society  

    DOI: 10.5551/jat.ed150

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  • Corrigendum to "A challenge for mutation specific risk stratification in long QT syndrome type 1" [J. Cardiol. 72(1) (2018) 56-65]. 国際誌

    Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno

    Journal of cardiology   77 ( 3 )   322 - 326   2021年3月

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  • A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium. 査読

    Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   29 ( 2 )   282 - 295   2021年2月

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    記述言語:英語   出版者・発行元:Japan Atherosclerosis Society  

    AIMS: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. METHODS: Japanese men aged 40-79y (n=869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCAmean), internal carotid artery (ICAmean) and bifurcation (Bifmean). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. RESULTS: All cIMT measures had positive associations with CAC (p<0.001): [OR, 95% Confidence Interval]: ICAmean [1.23, 1.07-1.42], CCAmean [1.27, 1.08-1.49], Bifmean [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile (p<0.05), while CCAmean had some of the weakest associations among age quartiles. CONCLUSIONS: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCAmean, was no longer associated with coronary calcium after age-adjustment and stratification.

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  • Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

    Ali Haidar Syaifullah, Akihiko Shiino, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Takahiro Ito, Hiroyoshi Segawa, Mohammad Moniruzzaman, Takashi Waki, Naoko Miyagawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura, Minoru Horie, Yoshihisa Nakagawa, Takashi Yamamoto, Yasutaka Nakano, Emiko Ogawa, Hiroshi Maegawa, Katsutaro Morino, Itsuko Miyazawa, Yoshiyuki Watanabe, Kazuhiko Nozaki, Akira Andoh, Teruhiko Tsuru, Hisakazu Ogita, Naomi Miyamatsu, Yasuyuki Nakamura, Sayuki Torii, Takashi Kadowaki, Sayaka Kadowaki, Sentaro Suzuki, Ayako Kunimura, Aya Higashiyama, Tomonori Okamura, Koichiro Azuma, Tatsuya Sawamura, Michiya Igase, Yasuharu Tabara, Akira Sekikawa, Emma J.M. Barinas-Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Yoshitaka Murakami, Nagako Okuda, Hisatomi Arima, Atsushi Satoh, Yoshikuni Kita, Takashi Hisamatsu, Masahiko Yanagita, Robert D. Abbott, Seiko Ohno, Naoyuki Takashima, Maryam Zaid, Yoshino Saito

    Alcohol   90   57 - 65   2021年2月

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    掲載種別:研究論文(学術雑誌)  

    The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40–79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010–2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.

    DOI: 10.1016/j.alcohol.2020.11.006

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  • Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study. 査読 国際誌

    Mohammad Moniruzzaman, Aya Kadota, Akihiko Shiino, Akira Fujiyoshi, Takahiro Ito, Ali Haidar Syaifullah, Naoko Miyagawa, Keiko Kondo, Takashi Hisamatsu, Hiroyoshi Segawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of physical activity & health   18 ( 2 )   157 - 164   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Kinetics  

    BACKGROUND: To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. METHODS: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). RESULTS: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). CONCLUSIONS: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.

    DOI: 10.1123/jpah.2019-0659

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    その他リンク: https://journals.humankinetics.com/downloadpdf/journals/jpah/aop/article-10.1123-jpah.2019-0659/article-10.1123-jpah.2019-0659.xml

  • Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men. 査読 国際誌

    Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 1 )   80 - 87   2021年1月

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    記述言語:英語   出版者・発行元:Springer Science and Business Media LLC  

    Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40-79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

    DOI: 10.1038/s41440-020-00533-w

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  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS). 査読 国際誌

    Kei Asayama, Yasuharu Tabara, Emi Oishi, Satoko Sakata, Takashi Hisamatsu, Kayo Godai, Mai Kabayama, Yukako Tatsumi, Jun Hata, Masahiro Kikuya, Kei Kamide, Katsuyuki Miura, Toshiharu Ninomiya, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension   43 ( 12 )   1403 - 1412   2020年12月

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    記述言語:英語   出版者・発行元:Springer Science and Business Media LLC  

    Despite the clinical usefulness of self-measured home blood pressure (BP), reports on the characteristics of home BP have not been sufficient and have varied due to the measurement conditions in each study. We constructed a database on self-measured home BP, which included five Japanese general populations as subdivided aggregate data that were clustered and meta-analyzed according to sex, age category, and antihypertensive drug treatment at baseline (treated and untreated). The self-measured home BPs were collected after a few minutes of rest in a sitting position: (1) the morning home BP was measured within 1 h of waking, after urination, before breakfast, and before taking antihypertensive medication (if any); and (2) the evening home BP was measured just before going to bed. The pulse rate was simultaneously measured. Eligible data from 2000 onward were obtained. The morning BP was significantly higher in treated participants than in untreated people of the same age category, and the BP difference was more marked in women. Among untreated residents, home systolic/diastolic BPs measured in the morning were higher than those measured in the evening; the differences were 5.7/5.0 mmHg in women (ranges across the cohorts, 5.3-6.8/4.7-5.4 mmHg) and 7.3/7.7 mmHg in men (ranges, 6.4-8.5/7.0-8.7 mmHg). In contrast, the home pulse rate in women and men was 2.4 (range, 1.5-3.7) and 5.6 (range, 4.6-6.6) beats per minute, respectively, higher in the evening than in the morning. We demonstrated the current status of home BP and home pulse rate in relation to sex, age, and antihypertensive treatment status in the Japanese general population. The approach by which fine-clustered aggregate statistics were collected and integrated could address practical issues raised in epidemiological research settings.

    DOI: 10.1038/s41440-020-0530-1

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  • Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men. 査読 国際誌

    Mohammad Moniruzzaman, Aya Kadota, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Naoko Miyagawa, Akira Fujiyoshi, Takashi Hisamatsu, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Stroke   51 ( 12 )   3584 - 3591   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.

    DOI: 10.1161/STROKEAHA.120.030141

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  • The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. 査読 国際誌

    Aya Hirata, Akemi Kakino, Tomonori Okamura, Yoko Usami, Yoshiko Fujita, Aya Kadota, Akira Fujiyoshi, Takashi Hisamatsu, Keiko Kondo, Hiroyoshi Segawa, Tatsuya Sawamura, Katsuyuki Miura, Hirotsugu Ueshima

    Atherosclerosis   313   20 - 25   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    BACKGROUND AND AIMS: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). METHODS: We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). RESULTS: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively. CONCLUSIONS: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.

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  • Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey 査読

    Toshiki Sanoh, Eri Eguchi, Tetsuya Ohira, Fumikazu Hayashi, Masaharu Maeda, Seiji Yasumura, Yuriko Suzuki, Hirooki Yabe, Atsushi Takahashi, Kanae Takase, Mayumi Harigane, Takashi Hisamatsu, Keiki Ogino, Hideyuki Kanda, Kenji Kamiya

    International Journal of Environmental Research and Public Health   17 ( 21 )   7832 - 7832   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Evidence regarding the effect of psychological factors and evacuation on cardiovascular disease occurrence after large-scale disasters is limited. This prospective study followed up a total of 37,810 Japanese men and women aged 30–89 years from the Fukushima Prefecture with no history of stroke or heart disease at baseline (2012), until 2017. This period included 3000 cardiovascular events recorded through questionnaires and death certificates. The participants’ psychological distress, trauma reaction, and evacuation status were defined, and divided into four groups based on combinations of psychological factors and evacuation status. We calculated the hazard ratios and 95% confidence intervals for only psychological, only evacuation, or both of them compared with neither using Cox proportional hazard models. Psychological factors along with evacuation resulted in approximately 5% to 25% higher magnitude of stroke and heart disease risk than psychological factors only among men. Compared to neither, the multivariable hazard ratios of those with both psychological distress and evacuation were 1.75 for stroke and 1.49 for heart disease, and those of both trauma reaction and evacuation were 2.01 and 1.57, respectively, among men. Evacuation combined with psychological factors increased the risk of stroke and heart disease risks especially in men after the Great East Japan Earthquake.

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  • The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study. 査読

    Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   27 ( 9 )   995 - 1009   2020年9月

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    記述言語:英語   出版者・発行元:Japan Atherosclerosis Society  

    AIM: Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs in a healthy Japanese male population. METHODS: In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. CAC was scored using the Agatston method. The following SCVDs were assessed using magnetic resonance imaging: intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds. The participants were categorized according to CAC scores as follows: no CAC (0), mild CAC (1-100), and moderate-to-severe CAC (>100). The adjusted odds ratios of prevalent SCVDs were computed in reference to the no-CAC group using logistic regression. RESULTS: The mean (standard deviation) age of the participants was 68 (8.4) years. Participants in the moderate-to-severe CAC category showed significantly higher odds of prevalent lacunar infarction, DSWMH, and ICAS in age-adjusted and risk-factor-adjusted models. Microbleeds and PVH, in contrast, did not show any significant associations. The trends for CAC with lacunar infarction, DSWMH, and ICAS were also significant (all P-values for trend ≤ 0.02). CONCLUSIONS: Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels.

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  • Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1. 査読 国際誌

    Hideki Itoh, Takashi Hisamatsu, Takuhisa Tamura, Kazuhiko Segawa, Toshiaki Takahashi, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Shugo Suwazono, Shingo Sasaki, Ken Okumura, Minoru Horie, Masanori P Takahashi, Tsuyoshi Matumura

    Journal of the American Heart Association   9 ( 17 )   e015709   2020年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ovid Technologies (Wolters Kluwer Health)  

    Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow-up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow-up period of 87 months (Q1-Q3, 37-138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22-15.50) were associated with sudden death. In contrast, PQ interval ≥240 ms, QRS duration ≥120 ms, nutrition, or respiratory failure were not associated with the incidence of sudden death. The multivariable analysis revealed that a PQ interval ≥240 ms (HR, 2.79; 95% CI, 1.9-7.19, P<0.05) or QRS duration ≥120 ms (HR, 9.41; 95% CI, 2.62-33.77, P < 0.01) were independent factors associated with a higher occurrence of cardiac events than those observed with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. Conclusions Cardiac conduction disorders are independent markers associated with cardiac events. Further investigation on the prediction of occurrence of sudden death is warranted.

    DOI: 10.1161/JAHA.119.015709

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  • Smoking habits and progression of coronary and aortic artery calcification: A 5-year follow-up of community-dwelling Japanese men 査読

    Tai Pham, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Ayako Kunimura, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    International Journal of Cardiology   314   89 - 94   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    Background and aims: To examinewhether smoking habits, including smoking amount and cessation duration at baseline, are associated with atherosclerosis progression.Methods: At baseline (2006-08, Japan), we obtained smoking status, amount of smoking and timesince cessation for quitters in a community-based randomsample of Japanesemen initially aged 40-79 years and free of cardiovascular disease. Coronary artery calcification (CAC) and aortic artery calcification (AAC) as biomarker of atherosclerosis was quantified using Agatston's method at baseline and after 5 years of follow-up. We defined progression of CAC and AAC (yes/no) using modified criteria by Berry.Results: A total of 781 participants was analyzed. Multivariable adjusted odds ratios (ORs) of CAC and AAC progression for current smokers were 1.73 (95% CI, 1.09-2.73) and 2.47 (1.38-4.44), respectively, as compared to never smokers. In dose-response analyses, we observed a graded positive relationship of smoking amount and CAC progression in current smokers (multivariable adjusted ORs: 1.23, 1.72, and 2.42 from the lowest to the highest tertile of pack-years). Among the former smokers, earlier quitters (>= 10.7 years) had similar ORs of the progression of CAC and AAC to that of participants who had never smoked.Conclusions: Comparedwith never smokers, current smokers especially thosewith greater pack-years at baseline had higher risk of atherosclerosis progression in community-dwelling Japanese men. Importantly, the residual adverse effect appears to be present for at least ten years after smoking cessation. The findings highlight the importance of early avoidance or minimizing smoking exposure for the prevention of atherosclerotic disease. (c) 2020 Elsevier B.V. All rights reserved.

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  • 日本人一般男性を対象とした脳MRIを用いた無症候性脳血管疾患と四つの血圧指標との関連性評価(Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men) 査読

    Salman Ebtehal, Kadota Aya, Hisamatsu Takashi, Segawa Hiroyoshi, Torii Sayuki, Fujiyoshi Akira, Kondo Keiko, Arima Hisatomi, Shiino Akihiko, Miura Katsuyuki, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   84回 ( 2 )   OE118 - 3   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本循環器学会  

    AIM: The relationship of blood pressure (BP) indexes (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], mean arterial pressure [MAP]) to subclinical cerebrovascular diseases (SCVDs) remains unclear. This study aimed to elucidate the relationship of four BP indexes measured at two visits on SCVDs assessed by magnetic resonance imaging (MRI) in general Japanese men. METHODS: In general Japanese men aged 40-79 years (N=616), office BP indexes were measured at two visits (Visits 1 [2006-2008] and 2 [2010-2014]). MRI images obtained on the third visit (2012-2015) were examined for prevalent SCVDs: lacunar infarction, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), microbleeds, and intracranial artery stenosis (ICAS). Using a multivariable logistic regression analysis, we computed and estimated the odds ratio of each prevalent SCVD for one standard deviation higher BP indexes. The same analyses were performed using home BP. RESULTS: All four office BP indexes at both visits associated with lacunar infarction. Visit 1 and 2 DBP and Visit 1 MAP associated with PVH and DSWMH, and Visit 1 SBP associated with DSWMH. All Visit 2 BP indexes appear to show stronger association with microbleeds than Visit 1 indexes, and Visit 1 and 2 SBP, PP, and MAP showed similar associations with ICAS. Additional analyses using home BP indexes revealed similar relationships; however, the significance of some relationships decreased. CONCLUSION: In general Japanese men, BP indexes were associated with most of SCVDs, and BP indexes measured at different periods associated with different SCVDs assessed by MRI.

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  • Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. 査読

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Sayuki Torii, Naoyuki Takashima, Ikuo Tooyama, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 6 )   244 - 252   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    BACKGROUND: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. METHODS: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score, with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. RESULTS: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend = 0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend = 0.015) in mutual-adjustment model. CONCLUSIONS: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.

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  • Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study. 査読

    Ziyi Liu, Maryam Zaid, Takashi Hisamatsu, Sachiko Tanaka, Akira Fujiyoshi, Naoko Miyagawa, Takahiro Ito, Aya Kadota, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 3 )   121 - 127   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.

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  • Physical activity levels in American and Japanese men from the ERA-JUMP Study and associations with metabolic syndrome. 査読 国際誌

    Naoko Sagawa, Bonny Rockette-Wagner, Koichiro Azuma, Hirotsugu Ueshima, Takashi Hisamatsu, Tomoko Takamiya, Aiman El-Saed, Katsuyuki Miura, Andrea Kriska, Akira Sekikawa

    Journal of sport and health science   9 ( 2 )   170 - 178   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    Background: Metabolic syndrome (MetS) is a global health problem. Physical activity (PA) is a known modifiable risk factor for MetS and individual MetS components. However, the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors. To examine these differences, multi-country studies with standardized outcome measurement methods across cohorts are needed. Methods: Cross-sectional PA levels (total and domain specific) in healthy middle-aged (44-56 years) men in the Risk Factor Assessment among Japanese and U.S. Men in the Post-World War II Birth Cohort (ERA-JUMP) Study (n = 730; American: n = 417; Japanese: n = 313; from population-representative samples in Pittsburgh, Pennsylvania, USA, and Kusatsu, Shiga, Japan) were compared. The relationships between PA levels and MetS (overall and specific components) in/across the American and Japanese sub-cohorts (adjusting for age, smoking, and alcohol consumption) were also assessed using the same instruments (pedometer and validated questionnaire) to measure PA in both cohorts. Results: A total of 510 individuals provided complete data on PA (American: n = 265; Japanese: n = 245). The American cohort had significantly lower mean ± SD steps/day (7878 ± 3399 steps/day) vs. the Japanese cohort (9055 ± 3797 steps/day) (p < 0.001) but had significantly higher self-reported moderate-vigorous leisure PA (American: 15.9 (7.4-30.3) metabolic task equivalent hours per week (MET-h/week) vs. Japanese: 4.0 (0-11.3) MET-h/week, p < 0.0001). In both sub-cohorts, each 1000 steps/day increase was associated with lower odds of having MetS (American: OR = 0.90, 95%CI: 0.83-0.98; Japanese: OR = 0.87, 95%CI: 0.79-0.95) and the individual MetS component of high waist circumference (American: OR = 0.86, 95%CI: 0.79-0.94; Japanese: OR = 0.87, 95%CI: 0.80-0.95). In the American cohort only, higher self-reported leisure PA (Met-h/week) was associated with lower odds of MetS and high waist circumference (OR = 0.98, 95%CI: 0.97-0.99 for MetS and waist circumference, respectively). Conclusion: Higher total step counts/day had an important protective effect on MetS prevalence in both the Japanese and American cohorts, despite differences in PA levels and other MetS risk factors. The effect of steps/day (across all intensity levels) was much greater than domain-specific moderate-vigorous PA captured by questionnaire, suggesting the need for measurement tools that can best capture total movement when examining the effects of PA on MetS development.

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  • Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis). 査読

    FUSE, Keiko, KADOTA, Aya, KONDO, Keiko, MORINO, Katsutaro, FUJIYOSHI, Akira, HISAMATSU, Takashi, KADOWAKI, Sayaka, MIYAZAWA, Itsuko, UGI, Satoshi, MAEGAWA, Hiroshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group, 布施, 恵子, 門田, 文, 近藤, 慶子, 森野, 勝太郎, 藤吉, 朗, 久松, 隆史, 門脇, 紗也佳, 宮澤, 伊都子, 卯木, 智, 前川, 聡, 三浦, 克之, 上島, 弘嗣

    Diabetes research and clinical practice   160   108002 - 108002   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Scientific Publishers  

    type:Journal Article
    AIMS:Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM.
    METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models.
    RESULTS:Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2.
    CONCLUSIONS:Liver fat accumulation assessed by CT was associated with the incidence of DM.

    DOI: 10.1016/j.diabres.2020.108002

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    その他リンク: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04074/

  • Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men. 査読

    Yuyan Liu, Akira Fujiyoshi, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Itsuko Miyazawa, Keiko Kondo, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   26 ( 12 )   1102 - 1114   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Computed tomography (CT) can directly provide information on body compositions and distributions, compared to anthropometric indices. It has been shown that various obesity indices are associated with carotid intima-media thickness (IMT). However, whether CT-based obesity indices are stronger than anthropometric indices in association with atherosclerosis remains to be determined in a general population. METHODS: We cross-sectionally assessed carotid IMT using ultrasound in 944 community-dwelling Japanese men free of stroke and myocardial infarction. CT image at the L4-L5 level was obtained to compute areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Anthropometric measures assessed included body mass index (BMI), waist circumference, and waist-to-hip ratio. Using multivariable linear regression, slopes of IMT per 20th to 80th percentile of each index were compared. We also compared the slope of index with simultaneous adjustment for BMI in the same model. RESULTS: Areas of VAT and SAT were positively associated with IMT, but not stronger than those of anthropometric indices in point estimates. Among all obesity indices, BMI was strongest in association with IMT after adjusting for age and lifestyle factors or further adjusting for metabolic factors. In simultaneous adjustment models, BMI, but not CT-based indices, remained significant and showed the strongest association. CONCLUSIONS: In community-dwelling Japanese men, anthropometric obesity indices, BMI in particular, were more strongly associated with carotid atherosclerosis than CT-based obesity indices. The association of general obesity with carotid atherosclerosis was strong and adding CT-based obesity measure did not considerably influence in the association.

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  • Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men 査読 国際誌

    Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Open Heart   6 ( 2 )   e001119 - e001119   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ  

    <sec><title>Objective</title>This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese).

    </sec><sec><title>Methods</title>In a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD).

    </sec><sec><title>Results</title>The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=−2% to 3%).

    </sec><sec><title>Conclusions</title>Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.

    </sec>

    DOI: 10.1136/openhrt-2019-001119

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  • The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. 査読 国際誌

    Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of hypertension   37 ( 8 )   1676 - 1681   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men. METHODS: We analyzed the data of 919 Japanese male participants who were randomly selected from general population (mean age 64.5 years). OBP was measured twice consecutively by a trained nurse using electrical device after 5 min of complete rest alone in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during 7 consecutive days. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score at least 10. We calculated odds ratios for the presence of CAC per one SD higher OBP and HBP adjusted for age and other cardiovascular risk factors. RESULTS: The mean systolic OBP (SD) and HBP (SD) were 136.8 (19.0) and 137.2 (18.5) mmHg, respectively, without statistical difference between the two (P = 0.595). OBP and HBP were highly correlated (r = 0.74 P < 0.001). CAC was found in 454 (49.4%) participants. Multivariable-adjusted odds ratios [95% confidence interval (CI)] for the presence of CAC were comparable between OBP (1.32, 95% CI: 1.12-1.56) and HBP (1.35, 95% CI: 1.14-1.60) (P heterogeneity = 0.813). CONCLUSION: The strength of association of accurately measured OBP with CAC was comparable with that of HBP among randomly selected male general population aged 40-79 years.

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, for the NIPPON DATA, Research Group

    Journal of atherosclerosis and thrombosis   26 ( 8 )   746 - 746   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.ER17244

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  • Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

    Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   29 ( 6 )   205 - 212   2019年6月

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    記述言語:英語  

    BACKGROUND: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. METHODS: From 2006-2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1-160.9, 161-321.9, 322-482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. RESULTS: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. CONCLUSIONS: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

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  • Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men 査読

    Cecilia Kimani, Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Maryam Zaid, Sayaka Kadowaki, Takashi Hisamatsu, Hisatomi Arima, Minoru Horie, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   26 ( 5 )   452 - 464   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    AIMS: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. METHODS: We examined a random sample of 1035 Japanese men aged 40-79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1-Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. RESULTS: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77-2.98] for CAC and 3.48 [2.57-4.73] for AAC), p for difference <0.001), systolic blood pressure (1.29 [1.08-1.53] and 1.28 [1.07-1.54], p for difference=0.270), and smoking (1.22, [1.04-1.43] and 1.34 [1.13-1.58]) p for difference=0.071). Alcohol correlated with AAC only (1.17 [0.97-1.41] for CAC and 1.42 [1.16-1.73] for AAC, p for difference= 0.020). CONCLUSIONS: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

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  • Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men 査読

    Itsuko Miyazawa, Takayoshi Ohkubo, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Matthew Budoff, Kiyoshi Murata, Katsuyuki Miura, Hiroshi Maegawa, Hirotsugu Ueshima

    Circulation Journal   82 ( 10 )   2542 - 2548   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Circulation Society  

    BACKGROUND: Pericardial fat volume (PFV), defined as the volume of ectopic fat in and around the heart, is associated with the atherosclerotic process in coronary arteries. The magnitude of change in PFV over time and the factors affecting this change in a general population, however, have not been investigated. Methods and Results: Cardiac computed tomography (CT) was carried out at baseline and at follow-up in 623 Japanese men aged 40-79 years without a history of cardiovascular disease who were selected randomly in Kusatsu (Shiga, Japan). PFV was measured on cardiac CT in a qualified laboratory. Age, heart rate, triglycerides, and obesity measurements (weight, body mass index, and waist circumference) were significantly and positively associated with PFV at baseline. Over an average interval of 4.7 years, median PFV increased significantly from 64.1 cm3 (IQR, 47.2-90.0 cm3) to 73.6 cm3 (IQR, 53.3-98.1 cm3; P<0.001). Current smoking and heart rate were significantly and independently associated with changes in PFV (B=3.336, P<0.001 and B=6.409, P=0.003, respectively). CONCLUSIONS: PFV increased significantly over time in a population-based observational study of Japanese men. PFV change was significantly and independently associated with smoking status and heart rate, suggesting that quitting smoking might help reduce PFV, which could be expected to decrease the risk of coronary artery disease.

    DOI: 10.1253/circj.cj-18-0153

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  • Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea 査読

    Abhishek Vishnu, Jina Choo, Aya Kadota, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Dorothy Leann Long, Takashi Hisamatsu, Vasudha Ahuja, Yasuyuki Nakamura, Rhobert W. Evans, Katsuyuki Miura, Kamal H. Masaki, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    International Journal of Cardiology   266   245 - 249   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. Methods: We conducted a population-based study among apparently healthy middle-aged men aged 40–49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. Results: Whites (22.8%) had more than four-fold higher prevalence (p &lt
    0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors – incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. Conclusion: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.

    DOI: 10.1016/j.ijcard.2018.03.010

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  • Corrigendum to "Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population." [Atherosclerosis 246 (March 2016) 141-147]. 査読 国際誌

    Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, ACCESS, SESSA Research Groups

    Atherosclerosis   278   336 - 336   2018年8月

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  • Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men. 査読

    Takashi Hisamatsu

    European journal of clinical nutrition   73 ( 5 )   783 - 792   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    BACKGROUND/OBJECTIVES:Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. SUBJECTS/METHODS:The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. RESULTS:Prevalence of CCS > 0, ≥ 100, and ≥ 300 was 65.8%, 25.9%, and 12.9%, respectively; the mean (SD) OM3, EPA, and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100, and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81-1.03, p = 0.12), 0.99 (0.88-1.11, p = 0.87) and 0.84 (0.74-0.94, p = < 0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77-0.99, p = 0.03). Blood levels of OM3, EPA, or DHA did not have any significant associations with CDS. CONCLUSIONS:DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes.

    DOI: 10.1038/s41430-018-0242-7

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  • Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

    Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   25 ( 6 )   477 - 489   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization. We examined an independent relationship between each risk factor used in prediction models and CAC score ≥100 by logistic regression. We then divided the participants into quintiles of estimated CHD risk per prediction model to calculate odds ratio of having CAC score ≥100. Receiver operating characteristic curve and c-index were used to examine discriminative ability of prevalent CAC for each prediction model. RESULTS: Age, smoking status, and systolic blood pressure were significantly associated with CAC score ≥100 in the multivariable analysis. The odds of having CAC score ≥100 were higher for those in higher quintiles in all prediction models (p-values for trend across quintiles <0.0001 for all models). All prediction models showed fair and similar discriminative abilities to detect CAC score ≥100, with similar c-statistics (around 0.70). CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population.

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  • International Comparison of Abdominal Fat Distribution Among Four Populations: The ERA-JUMP Study.

    Takashi Hisamatsu

    Metabolic syndrome and related disorders   2018年5月

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    掲載種別:研究論文(学術雑誌)  

    BACKGROUND:Abdominal fat distribution varies across groups with different races or environments. Whether environmental factors, apart from racial differences, affect abdominal fat distribution is unknown. METHODS:We compared the abdominal fat distribution of four groups; different races with similar environments (Caucasians vs. Japanese Americans), different environments with an identical race (Japanese Americans vs. Japanese), and similar races with similar environments (Japanese vs. Koreans). A population-based sample of 1212 men aged 40-49 were analyzed: 307 Caucasians and 300 Japanese Americans in the United States, 310 Japanese in Japan, and 295 Koreans in Korea. We compared the proportion of visceral adipose tissue area to total abdominal adipose tissue area (VAT%) and other factors that can affect abdominal fat distribution (smoking, alcohol use, physical activity levels, and metabolic factors). RESULTS:VAT% was significantly higher in Japanese and Koreans than in Japanese Americans and Caucasians (50.0, 48.5, 43.2, 41.0%, respectively, P < 0.001). Even after adjustment for possible confounders, the significant VAT% difference remained in comparing groups with identical race but different environments (i.e., Japanese vs. Japanese Americans). In contrast, comparing groups with different races but similar environments (i.e., Caucasians vs. Japanese Americans), VAT% was not significantly different. Comparing groups with similar races and similar environments (i.e., Japanese vs. Koreans), VAT% did not significantly differ. CONCLUSIONS:Environmental differences, apart from racial differences, affect the difference in abdominal fat distribution across different groups in middle-aged men.

    DOI: 10.1089/met.2017.0132

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  • Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study. 査読

    Takashi Hisamatsu

    Data in brief   17   1091 - 1098   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Data presented in this article are supplementary data to our primary article 'Association of Alcohol Consumption and Aortic Calcification in Healthy Men Aged 40-49 Years for the ERA JUMP Study' [1]. In this article, we have presented supplementary tables showing the independent association of alcohol consumption with coronary artery calcification using Tobit conditional regression and ordinal logistic regression.

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  • Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

    Takashi Hisamatsu

    Journal of atherosclerosis and thrombosis   25 ( 10 )   1009 - 1021   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    AIM:We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population. METHODS:We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation. The pulmonary function test was performed to assess the forced expiratory volume in 1 second (FEV1) % predicted and forced vital capacity (FVC) % predicted values. Cranial MRI was performed to evaluate the white matter lesions (WMLs) and lacunar infarcts. We examined the association of the WMLs and lacunar infarcts with a 1-standard deviation (SD) lower in the FEV1 % predicted and FVC % predicted, on the basis of the smoking status. RESULTS:A total of 473 men were examined. The association of WMLs and lacunar infarcts with the spirometry-based indices were significant only in never smokers. The association between lung function impairment and cerebral small vessel disease did not change after further adjusting for second-hand smoke exposure. CONCLUSION:In a community-based sample of Japanese men, we found an association between reduced lung function and WMLs and lacunar infarcts in never smokers.

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  • Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men 査読

    Suzuki Sentaro, Arima Hisatomi, Miyazaki Soichiro, Fujiyoshi Akira, Kadota Aya, Takashima Naoyuki, Hisamatsu Takashi, Kadowaki Sayaka, Zaid Maryam, Torii Sayuki, Horie Minoru, Murata Kiyoshi, Miura Katsuyuki, Ueshima Hirotsugu, the SESSA Research Group

    Journal of Atherosclerosis and Thrombosis   25 ( 2 )   186 - 198   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般社団法人 日本動脈硬化学会  

    <p>Aim: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men.</p><p>Methods: This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire; CAC by computed tomography; and carotid IMT by ultrasonography.</p><p>Results: The prevalence of CAC was 50.0% for participants with sleep duration <5.5 h, 43.9% with 5.5–6.4 h, 50.0% with 6.5–7.4 h, 49.3% with 7.5–8.4 h, and 62.5% with ≥8.5 h. In univariate analysis, participants with sleep duration ≥8.5 h had significantly higher prevalence of CAC than those with 6.5–7.4 h (p=0.043). After adjustment for age and other risk factors, however, the association was not significant (p=0.776). The average IMT was 0.85 mm for participants with sleep duration <5.5 h, 0.83 mm with 5.5–6.4 h, 0.85 mm with 6.5–7.4 h, 0.88 mm with 7.5–8.4 h, and 0.90 mm with ≥8.5 h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p>0.1).</p><p>Conclusion: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men.</p>

    DOI: 10.5551/jat.40527

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  • Association of alcohol consumption and aortic calcification in healthy men aged 40–49 years for the ERA JUMP Study 査読

    Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Takashi Hisamatsu, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Tomonori Okamura, Abhishek Vishnu, Emma Barinas-Mitchell, Vasudha Ahuja, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    Atherosclerosis   268   84 - 91   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    Background and aims Several studies have reported a significant inverse association of light to moderate alcohol consumption with coronary heart disease (CHD). However, studies assessing the relationship between alcohol consumption and atherosclerosis have reported inconsistent results. The current study was conducted to determine the relationship between alcohol consumption and aortic calcification. Methods We addressed the research question using data from the population-based ERA-JUMP Study, comprising of 1006 healthy men aged 40–49 years, without clinical cardiovascular diseases, from four race/ethnicities: 301 Whites, 103 African American, 292 Japanese American, and 310 Japanese in Japan. Aortic calcification was assessed by electron-beam computed tomography and quantified using the Agatston method. Alcohol consumption was categorized into four groups: 0 (non-drinkers), ≤1 (light drinkers), &gt
    1 to ≤3 (moderate drinkers) and &gt
    3 drinks per day (heavy drinkers) (1 drink = 12.5 g of ethanol). Tobit conditional regression and ordinal logistic regression were used to investigate the association of alcohol consumption with aortic calcification after adjusting for cardiovascular risk factors and potential confounders. Results The study participants consisted of 25.6% nondrinkers, 35.3% light drinkers, 23.5% moderate drinkers, and 15.6% heavy drinkers. Heavy drinkers [Tobit ratio (95% CI) = 2.34 (1.10, 4.97)
    odds ratio (95% CI) = 1.67 (1.11, 2.52)] had significantly higher expected aortic calcification score compared to nondrinkers, after adjusting for socio-demographic and confounding variables. There was no significant interaction between alcohol consumption and race/ethnicity on aortic calcification. Conclusions Our findings suggest that heavy alcohol consumption may be an independent risk factor for atherosclerosis.

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  • Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men 査読

    Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa

    BRITISH JOURNAL OF NUTRITION   117 ( 2 )   260 - 266   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CAMBRIDGE UNIV PRESS  

    Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol &gt;83 nm. The presence of CAC was defined as a coronary Ca score 10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 5127 (interquartile range (IQR) 1941, 11700), 91 (IQR 010, 331) and 00 (IQR 00, 10) nm, respectively. Prevalence of CAC and equol-producers was 96 and 160 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 010 (95 % CI 001, 090, P&lt;004). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.

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  • The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men 査読

    Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Abhisek Vishnu, Aya Kadota, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Rhobert W. Evans, Bradley J. Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

    JOURNAL OF HYPERTENSION   35 ( 1 )   111 - 117   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: A few studies have examined the longitudinal association of blood pressure (BP) with arterial stiffness progression, and the results were inconsistent. The objective of this study was to investigate the roles of initial BP and its longitudinal change on the progression of arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV).
    Method: Study participants (n = 656) were from population-based samples of healthy men aged 40-49 years at baseline (213 White Americans, 47 AfricanAmericans, 152 Japanese Americans and 244 Japanese in Japan). BP measures, baPWV and other factors were examined at baseline and 4-7 years later. General linear regression was applied for statistical analyses.
    Result: Annual change in SBP (standardized coefficient: 0.33, P&lt;0.001), but not its baseline level (standardized coefficient: 0.03, P = 0.495), had a positive significant association with the progression of baPWV after adjusting for a wide range of standard cardiovascular risk factors. Similarly, annual changes in DBP (standardized coefficient: 0.35, P&lt;0.001), pulse pressure (standardized coefficient: 0.15, P = 0.001) and mean arterial pressure (standardized coefficient: 0.37, P&lt;0.001) were positively associated with the progression of baPWV. None of the baseline measures were related to the progression of baPWV.
    Conclusion: Our findings imply that, regardless of initial BP, effective monitoring and controlling of BP is important to slow down arterial wall stiffening and hence reduce cardiovascular risk.

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  • Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読 国際誌

    Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Koichiro Azuma, Sachiko Tanaka, Takashi Hisamatsu, Hisatomi Arima, Aya Kadota, Naoko Miyagawa, Naoyuki Takashima, Takayoshi Ohkubo, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima

    Preventive medicine reports   4   225 - 32   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40-64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m(2) (median, 23.5 kg/m(2)). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001-0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009-0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated.

    DOI: 10.1016/j.pmedr.2016.06.013

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  • Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers 査読

    Yasuharu Tabara, Hirotsugu Ueshima, Naoyuki Takashima, Takashi Hisamatsu, Akira Fujiyoshi, Maryam Zaid, Masaki Sumi, Katsuhiko Kohara, Tetsuro Miki, Katsuyuki Miura

    ATHEROSCLEROSIS   254   242 - 248   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background and aims: While alcohol consumption is known to increase plasma high-density lipoprotein (HDL) cholesterol levels, its relationship with low-density lipoprotein (LDL) cholesterol levels is unclear. Aldehyde dehydrogenase 2 (ALDH2) is a rate-controlling enzyme in alcohol metabolism, but a large number of Japanese people have the inactive allele. Here, we conducted a Mendelian randomization analysis using the ALDH2 genotype to clarify a causal role of alcohol on circulating cholesterol levels and lipoprotein particle numbers.
    Methods: This study was conducted in three independent general Japanese populations (men, n = 2289; women, n = 1940; mean age 63.3 +/- 11.2 years). Alcohol consumption was assessed using a questionnaire. Lipoprotein particle numbers were determined by nuclear magnetic resonance spectroscopy.
    Results: Alcohol consumption increased linearly in proportion to the number of subjects carrying the enzymatically active *1 allele in men (p &lt; 0.001). The *1 allele was also positively associated with HDL cholesterol level (adjusted mean +/- standard error, *1*1: 60 +/- 0.5, *1*2: 56 +/- 0.6, *2*2: 55 +/- 1.3 mg/dl, p &lt; 0.001) and inversely associated with LDL cholesterol level (116 +/- 0.9, 124 +/- 1.1, 130 +/- 2.6 mg/dl, p &lt; 0.001). The *1 allele was also positively associated with HDL particle numbers (per-allele: 2.60 +/- 0.32 mmol/l, p &lt; 0.001) and inversely associated with LDL particle numbers (-67.8 +/- 19.6 nmol/l, p = 0.001). Additional Mendelian randomization analysis failed to clarify the involvement of cholesteryl ester transfer protein in alcohol-related changes in lipoprotein cholesterol levels. No significant association was observed in women, presumably due to their small amount of alcohol intake.
    Conclusions: Alcohol consumption has a causal role in not only increasing HDL cholesterol levels but also decreasing LDL cholesterol levels and particle numbers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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  • Early repolarization and risk of arrhythmia events in long QT syndrome 査読

    Kanae Hasegawa, Hiroshi Watanabe, Takashi Hisamatsu, Seiko Ohno, Hideki Itoh, Takashi Ashihara, Hideki Hayashi, Takeru Makiyama, Tohru Minamino, Minoru Horie

    INTERNATIONAL JOURNAL OF CARDIOLOGY   223   540 - 542   2016年11月

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    記述言語:英語   出版者・発行元:ELSEVIER IRELAND LTD  

    DOI: 10.1016/j.ijcard.2016.08.215

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  • Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification 査読

    Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D. Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 5 )   1195 - 1202   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).
    OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDLC, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.
    METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; &gt;0 Agatston score) were examined.
    RESULTS: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.
    CONCLUSIONS: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P. (C) 2016 National Lipid Association. All rights reserved.

    DOI: 10.1016/j.jacl.2015.12.027

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  • Lipoprotein-associated phospholipase A(2) is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population 査読

    Hirotsugu Ueshima, Takashi Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Akira Sekikawa, Aya Kadota, Sayaka Kadowaki, Yasuyuki Nakamura, Naoko Miyagawa, Tomonori Okamura, Yoshikuni Kita, Naoyuki Takashima, Atsunori Kashiwagi, Hiroshi Maegawa, Minoru Horie, Takashi Yamamoto, Takeshi Kimura, Toru Kita

    ATHEROSCLEROSIS   246   141 - 147   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL). Lp-PLA2 is recognized as playing a key role in inflammatory processes and the development of atherosclerosis. This study aimed to investigate whether Lp-PLA2 is related to subclinical atherosclerosis, independently from traditional risk factors, in a general Japanese population by analyses of both the observational study and Mendelian randomization using V279F polymorphism.
    Methods and results: We cross-sectionally examined community-based sample of 929 Japanese men aged 40-79 years, without statin treatment, who were randomly selected from the resident registration. Multiple regression analyses of Lp-PLA2 activity and concentration were undertaken separately for men aged 40-49 years and 50-79 years, to clarify interactions of age and Lp-PLA2. Lp-PLA2 activity for men aged 50-79 years was significantly and positively related to intima-media thickness (IMT) (P = 0.013) and plaque index (P = 0.008) independent of traditional risk factors including small LDL particles, but not to coronary artery calcification (CAC) score. Associations with Lp-PLA2 concentration were qualitatively similar to those of activity. Corresponding relationships were not observed in men aged 40e49 years. Mendelian randomization analyses based on V279F genotype did not show any significant associations with subclinical atherosclerosis, although the homozygote and heterozygote of V279F showed low LpPLA2 activity and concentration.
    Conclusions: Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that LpPLA2 is a causative factor for subclinical atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  • Pediatric Cohort With Long QT Syndrome-KCNH2 Mutation Carriers Present Late Onset But Severe Symptoms - 査読

    Junichi Ozawa, Seiko Ohno, Takashi Hisamatsu, Hideki Itoh, Takeru Makiyama, Hiroshi Suzuki, Akihiko Saitoh, Minoru Horie

    CIRCULATION JOURNAL   80 ( 3 )   696 - 702   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE CIRCULATION SOC  

    Background: In children with long QT syndrome (LQTS), risk factors for cardiac events have been reported, but age-, gender-and genotype-related differences in prognosis remain unknown in Asian countries.
    Methods and Results: The study examined clinical prognosis at age between 1 and 20 years in 496 LQTS patients who were genotyped as either of LQT1-3 (male, n=206). Heterozygous mutations were observed in 3 major responsible genes: KCNQ1 in 271, KCNH2 in 192, and SCN5A in 33 patients. LQTS-associated events were classified into 3 categories: (1) syncope (n=133); (2) repetitive torsade de pointes (TdP, n=3); and (3) cardiopulmonary arrest (CPA, n=4). The risk of cardiac events was significantly lower in LQT1 girls than boys &lt;= 12 years (HR, 0.55), whereas LQT2 female patients &gt;= 13 years had the higher risk of cardiac events than male patients (HR, 4.60). Patients in the repetitive TdP or CPA group included 1 LQT1 female patient, 1 LQT2 male patient, and 5 LQT2 female patients. All LQT2 patients in these groups had TdP repeatedly immediately after the antecedent event. In addition, all 5 female LQT2 patients in these groups had the event after or near puberty.
    Conclusions: Female LQT2 children might have repeated TdP shortly after prior events, especially after puberty.

    DOI: 10.1253/circj.CJ-15-0933

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  • Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese 査読

    Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 1 )   172 - 180   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    BACKGROUND: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations.
    METHODS: A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody.
    RESULTS: Serum LAB levels (median [interquartile range], mu g cs/L) were 5341 mu g cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 mu m) compared with the first quartile (797 mu m) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC &gt;= 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 mu m (12.7), 856 mu m (16.7) in the low LAB/hypercholesterolemia group, and 833 mu m (8.4) in the low LAB/normal cholesterol group (P = .004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication.
    CONCLUSION: Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia. (C) 2016 National Lipid Association. All rights reserved.

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  • High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia 査読

    Keiko Sonoda, Hiroshi Watanabe, Takashi Hisamatsu, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Minoru Horie, Tohru Minamino

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   21 ( 1 )   30 - 40   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    BackgroundJ wave, or early repolarization has recently been associated with an increased risk of lethal arrhythmia and sudden death, both in idiopathic ventricular fibrillation and in the general population. Hypercalcemia is one of the causes of J point and ST segment elevation, but the relationship has not been well studied. The aim of this study was to examine the effects of hypercalcemia on J point elevation.
    MethodsElectrocardiographic findings were compared in 89 patients with hypercalcemia and 267 age- and sex-matched healthy controls with normocalcemia. The association of J point elevation with arrhythmia events in patients with hypercalcemia was also studied.
    ResultsThe PR interval and the QRS duration were longer in patients with hypercalcemia than in normocalcemic controls. Both the QT and the corrected QT intervals were shorter in patients with hypercalcemia compared with normocalcemic controls. Conduction disorders, ST-T abnormalities, and J point elevation were more common in patients with hypercalcemia than normocalcemic controls. Following the resolution of hypercalcemia, the frequency of J point elevation decreased to a level similar to that noted in controls. During hospitalization, no arrhythmia event occurred in patients with hypercalcemia.
    ConclusionHypercalcemia was associated with J point elevation.

    DOI: 10.1111/anec.12303

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  • Association between pulse wave velocity and coronary artery calcification in Japanese men the shiga epidemiological study of subclinical atherosclerosis (SESSA 査読

    Sayuki Torii, Hisatomi Arima, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saito, Naoko Miyagawa, Maryam Zaid, Yoshitaka Murakami, Robert D. Abbott, Minoru Horie, Katsuyuki Miura, SESSA Research Group, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   22 ( 12 )   1266 - 1277   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Atherosclerosis Society  

    Aim: Pulse wave velocity (PWV is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC is an intermediate stage in the process leading to overt cardiovascular disease (CVD and an established determinant of coro nary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. Methods: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC. Results: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles <1378, 1378-1563, 1564-1849, and >1849 cm/s (P< 0.001 for trend. Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P= 0.042 for trend. The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. Conclusions: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.

    DOI: 10.5551/jat.30247

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  • Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men 査読

    Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J. M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY   189   67 - 72   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men.
    Methods: A population-based sample of 1131men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as &gt;= 10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV.
    Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p &lt; 0.01), or by 36% per standard-deviation increase (p &lt; 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans.
    Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacks in the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijcard.2015.04.020

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  • High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men 査読

    Maryam Zaid, SESSA Research group, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Emiko Ogawa, Itsuko Miyazawa, Kiyoshi Murata, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Emma Barinas-Mitchell, Daniel Edmundowicz, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Takashi Kadowaki, Sayaka Kadowaki, Yoshitaka Murakami, Seiko Ohno

    Atherosclerosis   239 ( 2 )   444 - 450   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier Ireland Ltd  

    The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P&lt
    0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

    DOI: 10.1016/j.atherosclerosis.2015.01.031

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  • Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study 査読

    S. R. El Khoudary, C. Shin, K. Masaki, K. Miura, M. Budoff, D. Edmundowicz, S. Kadowaki, E. Barinas-Mitchell, A. El-Saed, A. Fujiyoshi, R. W. Evans, T. Hisamatsu, T. Ohkubo, B. J. Willcox, L. H. Kuller, H. Ueshima, A. Sekikawa

    INTERNATIONAL JOURNAL OF OBESITY   39 ( 3 )   488 - 494   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    BACKGROUND/OBJECTIVES: Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.
    SUBJECTS/METHODS: Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).
    RESULTS: Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values &lt; 0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value &lt; 0.05).
    CONCLUSIONS: Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.

    DOI: 10.1038/ijo.2014.154

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  • Comparison of HOMA-IR, HOMA-β%, and disposition index between U.S. Caucasian men and Japanese men in Japan: the ERA JUMP study 査読

    Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell E, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashiwagi A, Kuller LH, Ueshima H, Sekikawa A, for the ERA JUMP, Study Group

    Diabetologia   58 ( 2 )   265 - 271   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00125-014-3414-6

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  • Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study 査読

    Shin-ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   22 ( 6 )   590 - 598   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ATHEROSCLEROSIS SOC  

    Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians.
    Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models.
    Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all &lt; 0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC.
    Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.

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  • Long-term outcomes associated with prolonged PR interval in the general Japanese population 査読

    Takashi Hisamatsu, NIPPON DATA80 Research Group, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-Ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Fumiyoshi Kasagi, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshitaka Murakami, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara

    International Journal of Cardiology   184 ( 1 )   291 - 293   2015年

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    担当区分:筆頭著者, 責任著者   記述言語:英語   出版者・発行元:Elsevier Ireland Ltd  

    DOI: 10.1016/j.ijcard.2015.02.028

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  • Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis 査読

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Kadowaki, Sayaka Kadowaki, Maryam Zaid, Takashi Hisamatsu, Akira Sekikawa, Matthew J. Budoff, Kiang Liu, Hirotsugu Ueshima

    AMERICAN JOURNAL OF EPIDEMIOLOGY   180 ( 6 )   590 - 598   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    The incidence of coronary heart disease in the United States has declined, and prevalences of several coronary disease risk factors have become comparable to those in Japan. Therefore, the burden of coronary atherosclerosis may be closer among younger persons in the 2 countries. We aimed to compare prevalences of coronary atherosclerosis, measured with coronary artery calcium scores, between men in the 2 countries by age group (45-54, 55-64, or 65-74 years). We used community-based samples of Caucasian men in the United States (2000-2002; n = 1,067) and Japanese men in Japan (2006-2008; n = 832) aged 45-74 years, stratifying them into groups with 0, 1, 2, or &gt;= 3 of the following risk factors: current smoking, overweight, diabetes, dyslipidemia, and hypertension. We calculated adjusted odds ratios of US Caucasian men's having Agatston scores of &gt;= 10, &gt;= 100, and &gt;= 400 with reference to Japanese men. Overall, the odds of Caucasian men having each Agatston cutoff point were greater. The ethnic difference, however, became smaller in younger age groups. For example, adjusted odds ratios for Caucasian men's having an Agatston score of &gt;= 100 were 2.05, 2.43, and 3.86 among those aged 45-54, 55-64, and 65-74 years, respectively. Caucasian men in the United States had a higher burden of coronary atherosclerosis than Japanese men, but the ethnic difference was smaller in younger age groups.

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  • Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80 査読

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    ATHEROSCLEROSIS   232 ( 2 )   384 - 389   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake.
    Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population.
    Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake.
    Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37% kcal (0.86 g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P = 0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline).
    Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

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  • Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).

    Takashi Hisamatsu

    Journal of atherosclerosis and thrombosis   2013年7月

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    掲載種別:研究論文(学術雑誌)  

    AIM:To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart. METHODS:Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories Ⅰ, Ⅱ and Ⅲ of the guidelines were examined. RESULTS:The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean ± SD) (mm) for a 10-year absolute risk of ≥ 2.0% and ≥ 5.0%: 0.88 ± 0.18 and 0.95 ± 0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean ± SD) (mm) for Categories Ⅰ, Ⅱ, and Ⅲ: 0.70 ± 0.11, 0.81 ± 0.16 and 0.88 ± 0.18, respectively; mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category Ⅲ participants with or without DM and CKD. CONCLUSIONS:Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.

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  • Is more aggressive prevention of coronary artery disease required for patients with early repolarization syndrome?--Reply.

    Takashi Hisamatsu

    Circulation journal : official journal of the Japanese Circulation Society   77 ( 6 )   1643 - 1643   2013年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1253/circj.cj-13-0270

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  • Long-chain n-3 Polyunsaturated Fatty Acids Intake and Cardiovascular Disease Mortality Risk in a General Japanese Population: NIPPON DATA80 査読

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    STROKE   44 ( 2 )   2013年2月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Association between J-point elevation and death from coronary artery disease--15-year follow up of the NIPPON DATA90.

    Takashi Hisamatsu

    Circulation journal : official journal of the Japanese Circulation Society   2013年1月

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    掲載種別:研究論文(学術雑誌)  

    BACKGROUND:An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). METHODS AND RESULTS:To investigate the association between the presence of J-point elevation≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction<0.05). CONCLUSIONS:J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.

    DOI: 10.1253/circj.cj-12-1273

    PubMed

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  • Is More Aggressive Prevention of Coronary Artery Disease Required for Patients With Early Repolarization Syndrome? (Letter) 査読

    Hisamatsu T, Ohkubo T, Miura K, Horie M, Ueshima H

    Circ J   77 ( 6 )   1643   2013年

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    担当区分:筆頭著者, 責任著者  

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H

    J Atheroscler Thromb.?   20 ( 10 )   755 - 766   2013年

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  • Long-term risk of BP values above normal for cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years 査読 国際誌

    Takashima N, Ohkubo T, Miura K, Okamura T, Murakami Y, Fujiyoshi A, Nagasawa SY, Kadota A, Kita Y, Miyagawa N, Hisamatsu T, Hayakawa T, Okayama A, Ueshima H

    J Hypertens   30 ( 12 )   2209 - 2306   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/HJH.0b013e328359a9f7

    PubMed

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  • ループス腎炎に対する免疫抑制剤加療中に出現した尿蛋白量の減少にACE阻害薬(イミダプリル)が奏効した一例 査読

    下垣保恵, 筒井崇, 大平直人, 久松隆史, 田中雅博, 望月裕司, 豊田嘉清, 中井直治, 竹内孝男, 郡山健治, 河野厚

    臨床リウマチ   22 ( 4 )   389 - 393   2010年

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    記述言語:日本語   出版者・発行元:(一社)日本臨床リウマチ学会  

    50歳女性。患者はループス腎炎の寛解期に蛋白尿が出現した。蛋白尿はステロイドにタクロリムスとARB併用することで低下したが、正常範囲には至らず、ARBをACE-Iに変更したところ、正常値範囲に至った。

    J-GLOBAL

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J02269&link_issn=&doc_id=20110113250004&doc_link_id=10.14961%2Fcra.22.389&url=https%3A%2F%2Fdoi.org%2F10.14961%2Fcra.22.389&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

▼全件表示

書籍等出版物

  • 循環器病予防エビデンスブック

    久松隆史( 担当: 分担執筆 ,  範囲: 心疾患の動向)

    医歯薬出版  2021年6月 

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  • 健康教育マニュアル第2版

    ( 担当: 分担執筆 ,  範囲: 血圧測定法の種類と血圧分類; 高血圧薬物治療の原則)

    日本家族計画協会  2019年11月 

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  • Tobacco and Cardiovascular Disease. Vasan R and Sawyer D (Edit.). Encyclopedia of Cardiovascular Research and Medicine

    Kanda H, Hisamatsu T( 範囲: 537-544)

    Elsevier  2017年 

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  • 健康教育マニュアル

    久松隆史( 担当: 分担執筆 ,  範囲: 血圧測定法の種類と血圧分類; 高血圧薬物治療の原則)

    日本家族計画協会  2014年 

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MISC

  • 高血圧予防・管理における尿ナトリウム・カリウム比の重要性 -最近の知見と展望- 招待

    久松隆史

    第34回日本疫学会学術総会ランチョンセミナー3   2024年2月

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    担当区分:筆頭著者, 最終著者, 責任著者  

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  • 【減塩-循環器病予防のための効果と戦略】食塩と高血圧のエビデンス

    久松 隆史

    カレントテラピー   41 ( 9 )   784 - 790   2023年9月

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    記述言語:日本語   出版者・発行元:(株)ライフメディコム  

    食塩摂取と血圧との正の関連は,数多くの疫学研究,介入研究の確かなエビデンスに基づいて確立しており,減塩は最も重要な高血圧予防・管理対策のひとつである.Stamlerらは,高度に標準化された調査に基づく食塩摂取と血圧に関する疫学研究,INTERSALT研究を実施し,ナトリウム摂取量の多い集団では加齢に伴う血圧上昇の程度が大きいこと,また,個人間ではナトリウム摂取量と血圧値とは正の関連があることを明らかにした.米国のCARDIA研究では,若年成人時のナトリウムの過剰摂取が中年期までの血圧高値や高血圧発症リスク上昇と関連していた.また,TOHP IやDASH-sodium試験など複数の介入研究から減塩による降圧効果が示され,さらに介入研究のメタ分析から減塩と降圧効果の間には直線的な量反応関係があることが報告されている.本稿では,主として疫学研究や介入研究の成果に基づいて,食塩摂取と血圧に関する知見を概説する.(著者抄録)

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  • 【高血圧の病態と管理の最前線】公衆衛生による高血圧の予防と管理 ポピュレーションアプローチとハイリスクアプローチ

    久松 隆史, 三浦 克之

    腎と透析   95 ( 2 )   145 - 149   2023年8月

  • ステージ0からの心不全予防 我が国における心不全の疫学とNIPPON DATAからの新たな展開 招待

    久松 隆史, 三浦 克之

    日本循環器病予防学会誌   58 ( 2 )   130 - 130   2023年5月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • [減塩・栄養委員会企画]減塩に関する最近の動きと新知見 米国CARDIA研究からの新知見 若年成人期の尿中ナトリウム・カリウム排泄量と中年期までの血圧値の推移 招待

    久松 隆史

    日本高血圧学会総会プログラム・抄録集   44回   45 - 45   2022年10月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 飲酒と頭部MRI上の微小血管および大血管病変との関連 メンデルランダム化分析(滋賀動脈硬化疫学研究) 査読

    久松 隆史, 田原 康玄, 鳥居 さゆ希, 近藤 慶子, 門田 文, 矢野 裕一朗, 椎野 顯彦, 野崎 和彦, 岡村 智教, 上島 弘嗣, 三浦 克之

    日本動脈硬化学会総会プログラム・抄録集   54回   250 - 250   2022年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 【高齢者の循環器疾患-病態・臨床の最新知見-】高齢者循環器疾患の疫学 招待

    久松 隆史

    日本臨床   80 ( 7 )   1067 - 1073   2022年7月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   出版者・発行元:(株)日本臨床社  

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  • 心不全を識る、診る、予防する 招待 査読

    久松 隆史

    日本循環器病予防学会誌   57 ( 2 )   126 - 126   2022年5月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 一般集団における潜在性動脈硬化の実態解明と規定要因の探索のための疫学研究 招待

    久松 隆史

    Journal of Epidemiology   32 ( Suppl.1 )   86 - 86   2022年1月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 飲酒と冠動脈石灰化・冠動脈疾患発症との関連 メンデルランダム化分析 査読

    久松 隆史, 三浦 克之, 田原 康玄, 門脇 崇, 鳥居 さゆ希, 門田 文, 近藤 慶子, 藤吉 朗, 山本 孝, 中川 義久, 堀江 稔, 木村 剛, 岡村 智教, 上島 弘嗣

    日本アルコール・薬物医学会雑誌   56 ( 6 )   281 - 281   2021年12月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 地域におけるIoT高血圧管理研究が高血圧有病率・認知率・治療率・管理率へ与える影響

    久松 隆史, 福田 茉莉, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   80回   358 - 358   2021年11月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 海外留学ネットワーキングセミナー 招待

    久松隆史

    第84回日本循環器学会学術集会   2020年7月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

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  • 【最新の高血圧診療:「高血圧治療ガイドライン2019」後の展開】高血圧の成因、分類、疫学 高血圧の疫学

    久松 隆史, 三浦 克之

    診断と治療   108 ( 4 )   445 - 451   2020年4月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <Headline>1 国民の収縮期血圧平均値は、男女ともいずれの年齢階級においても過去約60年で大きく低下した一方、拡張期血圧平均値は、特に60歳未満の男性では低下傾向が明らかではない。2 高血圧有病率は依然高く、50歳以上の男性、60歳以上の女性ではおおよそ60%以上である状態が続いている。3 高血圧管理率は改善傾向にあるものの、男性では約40%、女性では約45%にとどまっており、現在のところ降圧薬内服者の半数以上は管理不十分である。4 2017年の高血圧者の推計数は計4,300万人、うち3,100万人(72%)が管理不良であった。5 日本国民の血圧水準、高血圧有病率、および高血圧管理率をさらに改善させるには、高血圧者に対するハイリスクアプローチと、国民全体でのポピュレーションアプローチを組み合わせた総合的な対策の積極的な推進が重要である。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00697&link_issn=&doc_id=20200422190004&doc_link_id=%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 【高血圧診療update-診断・治療の最新動向-】わが国の高血圧の疫学

    久松 隆史, 三浦 克之

    日本臨床   78 ( 2 )   204 - 209   2020年2月

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    記述言語:日本語   出版者・発行元:(株)日本臨床社  

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  • The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) 招待

    Hisamatsu T, Ohkubo T, Kadota A, Fujiyoshi A, Miura K, Ueshima H

    IDACO/IDHOCO/IDCARS Consortium Meeting 2019   2019年10月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

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  • 島根県益田市におけるIoTを活用した血圧管理プロジェクト 招待

    久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    第1回Digital Hypertension Conference   2019年10月

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

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  • 【循環器疾患を予防する】リスク因子の集積・メタボリックシンドロームと循環器疾患

    久松 隆史

    公衆衛生   83 ( 5 )   350 - 355   2019年5月

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    <文献概要>はじめに 循環器疾患の古典的なリスク因子である肥満,高血圧,糖尿病,脂質異常症が合併しやすいことは以前から知られていた.現在では,腹部肥満,特に内臓脂肪型肥満(インスリン抵抗性)を基盤として,血圧上昇,血糖高値,脂質異常が集積した病態が「メタボリックシンドローム」(metabolic syndrome)と定義されている.肥満が原因となって,先述のリスク因子が軽度でも集積して存在すると循環器疾患リスクが高くなることが知られており,メタボリックシンドロームは循環器疾患の一次予防において重要な概念となっている.わが国では,欧米諸国と比較して肥満者割合が依然として低い一方で,肥満を伴わないリスク因子保有・集積者における循環器疾患リスクがメタボリックシンドローム有所見者のそれと同等か,それよりも高いことが報告されるなど,非肥満者におけるリスク因子保有・集積の重要性が認識されている.本稿は,リスク因子の集積に焦点を当て,わが国の疫学研究成果を踏まえて循環器疾患への影響を検討する.さらに,循環器疾患一次予防に関する包括的なリスク評価と,公衆衛生上の対策について概説する.

    J-GLOBAL

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00447&link_issn=&doc_id=20190507110008&doc_link_id=10.11477%2Fmf.1401209138&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1401209138&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA 招待

    Takashi Hisamatsu

    Cardiovascular Epidemiology Seminar Series   2019年1月

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    担当区分:筆頭著者, 最終著者, 責任著者   記述言語:英語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

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  • [Coronary artery calcium:Its clinical utility in primary prevention.]

    Takashi Hisamatsu

    Clinical calcium   29 ( 2 )   215 - 223   2019年1月

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    Coronary artery calcium, quantified by computed tomography scanning, is one of the well-known measures of subclinical atherosclerosis. Coronary artery calcium is considered an end result from the long-term exposure to risk factors. CAC has been shown to improve risk stratification in asymptomatic individuals with intermediate-risk(e.g., an option to facilitate decision making)for primary prevention of atherosclerotic cardiovascular disease in the US/western countries. Coronary artery calcium also represents a surrogate of atherosclerosis burden. However, the lack of evidence regarding issues such as costs or radiation exposure related to measuring coronary artery calcium warrants further studies.

    DOI: 10.20837/4201902215

    PubMed

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  • 【動脈硬化とカルシウム〜カルシウムパラドックスの謎に迫る〜】一次予防における冠動脈石灰化の意義

    久松 隆史, 藤吉 朗, 三浦 克之

    Clinical Calcium   29 ( 2 )   215 - 223   2019年1月

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    記述言語:日本語   出版者・発行元:(株)医薬ジャーナル社  

    <文献概要>潜在性動脈硬化指標の一つとして,単純CTにより定量的に評価された冠動脈石灰化がある。一次予防において,危険因子への長期曝露の結果である冠動脈石灰化所見を用いることで,有効に動脈硬化性心血管病の発症を予測し,中等度リスク保有者の管理において治療方針の決定などリスクの層別化を行い得る可能性が検討されている。また,冠動脈石灰化は動脈硬化進展マーカーとしても用いられる。一方,冠動脈石灰化測定の費用対効果や放射線被曝の問題などでは確定的な結論が得られていない。一次予防における冠動脈石灰化の有用性の確立のために,わが国を含む冠動脈石灰化に関する研究の更なる発展およびエビデンスの集積が望まれる。

    J-GLOBAL

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02593&link_issn=&doc_id=20190204290010&doc_link_id=10.20837%2F4201902215&url=https%3A%2F%2Fdoi.org%2F10.20837%2F4201902215&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松隆史, 三浦克之, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 早川岳人, 神田秀幸, 岡村智教, 岡村智教, 岡山明, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   302 - 302   2019年

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  • (循環器病予防総説シリーズ 6:記述疫学編 2)わが国における心疾患の死亡率・罹患率の動向 査読

    久松隆史, 三浦克之

    日本循環器病予防学会誌   53 ( 1 )   1 - 8   2018年

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    担当区分:筆頭著者, 責任著者   記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    日本における衛生統計・地域の疫学調査成績や国際比較を通じて、心疾患の中でも死亡率が高く疫学的知見の豊富な冠動脈疾患を中心に、その危険因子も含めて時代的な推移を概説した。心疾患全体での粗死亡率が上昇している一方、急性心筋梗塞を含む冠動脈疾患の粗死亡率は必ずしも上昇していない。また、冠動脈疾患を年齢調整死亡率で比較すると、日本は依然男女とも世界の中で最低水準と考えられた。一方で、急性心筋梗塞罹患率の都市部、男性における増加傾向が一部の疫学研究から示されており、その死亡率も近い将来上昇傾向に転じる可能性が懸念された。

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  • アテローム動脈硬化性心血管疾患予防における冠動脈石灰化(Coronary Artery Calcification for Prevention of Atherosclerotic Cardiovascular Disease)

    Hisamatsu Takashi

    Shimane Journal of Medical Science   34 ( 1 )   1 - 5   2017年7月

  • 動脈・静脈疾患の疫学 血管疾患の疫学-国際比較-

    久松隆史, 三浦克之

    日本臨床   75 ( 増刊4 動脈・静脈の疾患(上) )   43 - 50   2017年

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    久松隆史

    上原記念生命科学財団研究報告集(CD-ROM)   31   1 - 6   2017年

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  • 潜在性動脈硬化症の疫学 5)喫煙の潜在性動脈硬化への影響

    久松隆史

    動脈硬化予防   16 ( 3 )   32 - 36   2017年

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    喫煙は動脈硬化性心血管病(atherosclerotic cardiovascular disease;ASCVD)に対する最大の予防可能な危険因子である。ASCVD発症前の一般健常集団において、喫煙習慣(現在喫煙・禁煙)、特に現在喫煙は、冠動脈・頸動脈・大動脈・末梢動脈を含む全身の潜在性動脈硬化の進展と強固に関連し、これらの進展は生涯喫煙量(pack-year)の多い喫煙者・禁煙者ほど大きく、一方、早期に禁煙した禁煙者ほど生涯非喫煙者に近づくものと考えられる。欧米諸国と比較して依然喫煙率が高いわが国におけるASCVDのさらなる予防のためには、防煙ならびに喫煙者における早期の禁煙の積極的な推進が重要である。(著者抄録)

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  • 冠動脈疾患と降圧療法 冠動脈疾患と高血圧(疫学)

    久松隆史, 三浦克之

    血圧   23 ( 7 )   460 - 465   2016年

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    記述言語:日本語   出版者・発行元:(株)先端医学社  

    高血圧は、冠動脈疾患を含む心血管病の代表的な危険因子であり、日常診療で最もよく遭遇する疾患である。人口の急速な高齢化や生活習慣の欧米化の進展に伴い、都市部を中心とした冠動脈疾患発症率の増加および、とくに男性における高血圧有病率の上昇が今後懸念され、またアジア人では冠動脈疾患に対する高血圧の寄与度は大きいことから、わが国における冠動脈疾患予防に関して、高血圧対策が重要であると再認識する必要がある。至適血圧を超えて血圧が高くなるほど冠動脈疾患の死亡・発症リスクは高くなり、わが国における冠動脈疾患死亡の50%以上が至適血圧を超える血圧高値に起因するものと推定される。ポピュレーションアプローチを用いて国民全体の収縮期血圧平均値を4mmHg低下させることにより、冠動脈疾患死亡数が年間約5千人減少すると推計される。(著者抄録)

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  • 身近に考えよう 循環器内科の素朴な疑問 検査 1):心電図 Question02 健康診断で心電図異常を認めた際,どのような所見がある場合に専門医に依頼すべきでしょうか?たとえば,期外収縮でも紹介すべきですか?脚ブロックやR波増高不良,Brugada型心電図などで悩むことが多くあります.

    久松隆史

    治療   98 ( 3 )   333 - 336   2016年

  • 心電図におけるJ-point上昇と生命予後の関係

    久松 隆史, 三浦 克之

    日本医事新報   ( 4750 )   58 - 59   2015年5月

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    記述言語:日本語   出版者・発行元:(株)日本医事新報社  

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  • 潜在性動脈硬化の規定要因:ERA JUMP,SESSAより

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   47th   119 - 119   2015年

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 高血圧の疫学から学ぶ公衆衛生の役割と展望

    久松隆史, 三浦克之

    Heart View   19 ( 4 )   25 - 33   2015年

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  • 危険因子 Lp-PLA2

    久松隆史, 上島弘嗣, 三浦克之

    動脈硬化予防   14 ( 1 )   113 - 118   2015年

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  • 高血圧治療ガイドラインJSH2014改訂と高血圧治療の展望 4 高血圧の疫学から学ぶ公衆衛生の役割と展望

    久松隆史, 三浦克之

    Heart View   19 ( 4 )   361 - 369   2015年

  • 我が国におけるHDLコレステロール値の推移とその関連要因の疫学的検討:NIPPON DATA・循環器疾患基礎調査を用いた統合データ解析,1990-2010年

    久松隆史, 尾島俊之, 中村保幸, 清原裕, 中川秀昭, 桑原和代, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本循環器病予防学会誌   50 ( 2 )   142 - 142   2015年

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  • 高血圧診療のup to date 高血圧の疫学

    久松隆史, 三浦克之

    月刊臨床と研究   91 ( 1 )   1 - 8   2014年

  • 高血圧治療ガイドラインJSH2014 2)疫学

    久松隆史, 三浦克之

    動脈硬化予防   13 ( 3 )   11 - 17   2014年

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  • 疫学 脳卒中疫学の国際比較

    久松隆史, 大久保孝義, 三浦克之

    日本臨床   72 ( 増刊5 最新臨床脳卒中学(上) )   44 - 51   2014年

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  • 【多リスク時代の新しいストラテジー トータル血管マネージメント】日本人の脳卒中、心筋梗塞、腎臓病に対するリスク因子の寄与度の違い わが国の疫学研究から

    久松 隆史, 大久保 孝義, 堀江 稔, 三浦 克之

    Mebio   27 ( 10 )   30 - 44   2010年10月

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  • 血圧高値とがん死亡との関連 一般成人を対象とした29年追跡研究(NIPPON DATA80)

    久松 隆史, 門田 文, 早川 岳人, 喜多 義邦, 原田 亜希子, 岡見 雪子, 近藤 慶子, 岡村 智教, 岡山 明, 上島 弘嗣, 三浦 克之

    日本高血圧学会総会プログラム・抄録集   45回   256 - 256   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 血圧高値とがん死亡との関連 一般成人を対象とした29年追跡研究(NIPPON DATA80)

    久松 隆史, 門田 文, 早川 岳人, 喜多 義邦, 原田 亜希子, 岡見 雪子, 近藤 慶子, 岡村 智教, 岡山 明, 上島 弘嗣, 三浦 克之

    日本高血圧学会総会プログラム・抄録集   45回   256 - 256   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 一般住民における客観的評価に基づく身体活動と家庭血圧との関連 益田研究

    田邉 莉奈, 久松 隆史, 絹田 皆子, 谷口 かおり, 福田 茉莉, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   282 - 282   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 健常一般集団を対象とした高血圧・循環器病に関する疫学・予防医学研究

    久松 隆史

    日本高血圧学会総会プログラム・抄録集   45回   209 - 209   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 家庭血圧測定日数と随時尿を用いた尿Na/K比、推定一日食塩・カリウム摂取量の変化に関する1年間の前向きパイロット研究 益田研究

    絹田 皆子, 久松 隆史, 福田 茉莉, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   408 - 408   2023年9月

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  • 地域住民における家庭血圧測定アドヒアランスとその関連要因の検討 1年間の測定値に基づくトラジェクトリー分析

    福田 茉莉, 久松 隆史, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   410 - 410   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 一般住民における客観的評価に基づく身体活動と家庭血圧との関連 益田研究

    田邉 莉奈, 久松 隆史, 絹田 皆子, 谷口 かおり, 福田 茉莉, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   282 - 282   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 健常一般集団を対象とした高血圧・循環器病に関する疫学・予防医学研究

    久松 隆史

    日本高血圧学会総会プログラム・抄録集   45回   209 - 209   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 地域住民における家庭血圧測定アドヒアランスとその関連要因の検討 1年間の測定値に基づくトラジェクトリー分析

    福田 茉莉, 久松 隆史, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   410 - 410   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 家庭血圧測定日数と随時尿を用いた尿Na/K比、推定一日食塩・カリウム摂取量の変化に関する1年間の前向きパイロット研究 益田研究

    絹田 皆子, 久松 隆史, 福田 茉莉, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本高血圧学会総会プログラム・抄録集   45回   408 - 408   2023年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 【高血圧の病態と管理の最前線】公衆衛生による高血圧の予防と管理 ポピュレーションアプローチとハイリスクアプローチ

    久松 隆史, 三浦 克之

    腎と透析   95 ( 2 )   145 - 149   2023年8月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

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  • 日本人一般集団における心電図での左室肥大所見および腎機能障害と循環器疾患死亡との関連 NIPPON DATA 90

    多田 美帆, 平田 あや, 桑原 和代, 門田 文, 近藤 慶子, 久松 隆史, 岡山 明, 三浦 克之, 上島 弘嗣, 岡村 智教

    日本循環器病予防学会誌   58 ( 2 )   147 - 147   2023年5月

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  • 季節毎の家庭血圧と無症候性微小脳血管障害との関連 益田研究

    久松 隆史, 絹田 皆子, 福田 茉莉, 児島 克英, 谷口 かおり, 中畑 典子, 神田 秀幸

    Journal of Epidemiology   33 ( Suppl.1 )   166 - 166   2023年2月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 中高生全国調査による酒類広告の曝露と月飲酒の関連

    吉田 啓太, 神田 秀幸, 久松 隆史, 桑原 祐樹, 金城 文, 吉本 尚, 伊藤 央奈, 春日 秀朗, 美濃部 るり子, 真栄里 仁, 地家 真紀, 松本 悠貴, 大塚 雄一郎, 井谷 修, 兼板 佳孝, 樋口 進, 尾崎 米厚

    Journal of Epidemiology   33 ( Suppl.1 )   133 - 133   2023年2月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • THE RELATIONSHIP BETWEEN SERUM PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 CONCENTRATION AND THE PREVALENCE OF CORONARY ARTERY CALCIUM

    Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Yuichiro Yano, Aya Kadota, Akira Fujiyoshi, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima

    JOURNAL OF HYPERTENSION   41   E328 - E328   2023年1月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • DIFFERENTIAL ASSOCIATION OF CIRCULATING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 WITH THE SUBCLINICAL CEREBRAL SMALL VESSEL DISEASE AND INTRACRANIAL ARTERY STENOSIS

    Ayako Kunimura, Yuichiro Yano, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    JOURNAL OF HYPERTENSION   41   E327 - E328   2023年1月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • 高血圧と社会的要因との関連 就労状況に注目して

    福田 茉莉, 久松 隆史, 絹田 皆子, 中畑 典子, 谷口 かおり, 神田 秀幸

    日本公衆衛生学会総会抄録集   81回   304 - 304   2022年9月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 青少年者におけるゲームに対する社会的対応の東アジアの動向とわが国の課題

    神田 秀幸, 福田 茉莉, 絹田 皆子, 久松 隆史

    日本公衆衛生学会総会抄録集   81回   321 - 321   2022年9月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 地域におけるIoT高血圧管理研究が高血圧有病率・認知率・治療率・管理率に与える影響

    久松 隆史, 福田 茉莉, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   81回   314 - 314   2022年9月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 地域住民のCOVID-19流行禍における身体活動量の推移 益田研究

    谷口 かおり, 久松 隆史, 福田 茉莉, 絹田 皆子, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   81回   313 - 313   2022年9月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • コロナ禍でわが国の国民の飲酒量は減ったのか?

    神田 秀幸, 福田 茉莉, 絹田 皆子, 久松 隆史

    日本アルコール・薬物医学会雑誌   57 ( 4 )   256 - 256   2022年8月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 飲酒と頭部MRI上の微小血管および大血管病変との関連 メンデルランダム化分析(滋賀動脈硬化疫学研究)

    久松 隆史, 田原 康玄, 鳥居 さゆ希, 近藤 慶子, 門田 文, 矢野 裕一朗, 椎野 顯彦, 野崎 和彦, 岡村 智教, 上島 弘嗣, 三浦 克之

    日本動脈硬化学会総会プログラム・抄録集   54回   250 - 250   2022年7月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 家庭血圧変動と食事摂取状況に関する検討 益田研究

    絹田 皆子, 中畑 典子, 久松 隆史, 福田 茉莉, 谷口 かおり, 神田 秀幸

    日本栄養・食糧学会大会講演要旨集   76回   197 - 197   2022年5月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 家庭血圧変動と食事摂取状況に関する検討 益田研究

    絹田 皆子, 中畑 典子, 久松 隆史, 福田 茉莉, 谷口 かおり, 神田 秀幸

    日本栄養・食糧学会大会講演要旨集   76回   197 - 197   2022年5月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

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  • 一般集団における潜在性動脈硬化の実態解明と規定要因の探索のための疫学研究

    久松 隆史

    Journal of Epidemiology   32 ( Suppl.1 )   86 - 86   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 2年間の前向き地域研究からみた室温・外気温が家庭血圧に与える影響 益田研究

    絹田 皆子, 久松 隆史, 福田 茉莉, 谷口 かおり, 中畑 典子, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   126 - 126   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 高血圧症と社会要因との関連 益田研究から

    福田 茉莉, 久松 隆史, 絹田 皆子, 中畑 典子, 谷口 かおり, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   111 - 111   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 高血圧症と社会要因との関連 益田研究から

    福田 茉莉, 久松 隆史, 絹田 皆子, 中畑 典子, 谷口 かおり, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   111 - 111   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 2年間の前向き地域研究からみた室温・外気温が家庭血圧に与える影響 益田研究

    絹田 皆子, 久松 隆史, 福田 茉莉, 谷口 かおり, 中畑 典子, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   126 - 126   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90

    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ

    Journal of Epidemiology   32 ( Suppl.1 )   124 - 124   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 日本人男性における血清イリシン値とMRIで測定した脳小血管負荷との関係(Relationship Between Serum Irisin Levels and MRI-measured Cerebral Small Vessel Disease Burden in Japanese Men)

    Moniruzzaman Mohammad, Kadota Aya, Hisamatsu Takashi, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Miyagawa Naoko, Fujiyoshi Akira, Watanabe Yoshiyuki, Shiino Akihiko, Nozaki Kazuhiko, Ueshima Hirotsugu, Miura Katsuyuki

    Journal of Epidemiology   32 ( Suppl.1 )   137 - 137   2022年1月

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    記述言語:英語   出版者・発行元:(一社)日本疫学会  

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  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90

    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ

    Journal of Epidemiology   32 ( Suppl.1 )   124 - 124   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

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  • 障害(disorder,disability,dysfunction)と疾患(disease):どこが違うのか? 公衆衛生学的な観点からみたdiseaseとdisorderの考え方

    神田 秀幸, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   131 - 131   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 公衆衛生の観点からみたアディクション 公衆衛生の観点からみたインターネット嗜癖・ゲーム障害

    神田 秀幸, 福田 茉莉, 絹田 皆子, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   150 - 150   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 公衆衛生の観点からみたアディクション 公衆衛生の観点からみたインターネット嗜癖・ゲーム障害

    神田 秀幸, 福田 茉莉, 絹田 皆子, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   150 - 150   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 障害(disorder,disability,dysfunction)と疾患(disease):どこが違うのか? 公衆衛生学的な観点からみたdiseaseとdisorderの考え方

    神田 秀幸, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   131 - 131   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 飲酒と冠動脈石灰化・冠動脈疾患発症との関連 メンデルランダム化分析

    久松 隆史, 三浦 克之, 田原 康玄, 門脇 崇, 鳥居 さゆ希, 門田 文, 近藤 慶子, 藤吉 朗, 山本 孝, 中川 義久, 堀江 稔, 木村 剛, 岡村 智教, 上島 弘嗣

    日本アルコール・薬物医学会雑誌   56 ( 6 )   281 - 281   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 地域一般住民における自己採血型簡易血液検査(指先採血)の導入と実施状況

    神田 秀幸, 久松 隆史, 福田 茉莉, 絹田 皆子, 中畑 典子, 谷口 かおり, 杉山 大典, 岡村 智教

    日本公衆衛生学会総会抄録集   80回   356 - 356   2021年11月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 地域におけるIoT高血圧管理研究が高血圧有病率・認知率・治療率・管理率へ与える影響

    久松 隆史, 福田 茉莉, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   80回   358 - 358   2021年11月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 地域一般住民における自己採血型簡易血液検査(指先採血)の導入と実施状況

    神田 秀幸, 久松 隆史, 福田 茉莉, 絹田 皆子, 中畑 典子, 谷口 かおり, 杉山 大典, 岡村 智教

    日本公衆衛生学会総会抄録集   80回   356 - 356   2021年11月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 地域住民男性における大豆イソフラボン代謝産物エクオールと冠動脈石灰化との横断的関連 SESSA研究

    藤吉 朗, 三浦 克之, 門田 文, 有馬 久富, 関川 暁, 近藤 慶子, 門脇 紗也佳, 岡見 雪子, 鈴木 春満, 久松 隆史, 中川 義久, 東山 綾, 岡村 智教, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   53回   248 - 248   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • ガイドラインから発展する筋強直性ジストロフィー診療 筋強直性ジストロフィーの心障害とエビデンスの実装

    伊藤 英樹, 久松 隆史, 田村 拓久, 瀬川 和彦, 高橋 俊明, 高田 博仁, 久留 聡, 和田 千鶴, 鈴木 幹也, 諏訪園 秀吾, 佐々木 真吾, 奥村 謙, 堀江 稔, 高橋 正紀, 松村 剛

    臨床神経学   61 ( Suppl. )   S205 - S205   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • ガイドラインから発展する筋強直性ジストロフィー診療 筋強直性ジストロフィーの心障害とエビデンスの実装

    伊藤 英樹, 久松 隆史, 田村 拓久, 瀬川 和彦, 高橋 俊明, 高田 博仁, 久留 聡, 和田 千鶴, 鈴木 幹也, 諏訪園 秀吾, 佐々木 真吾, 奥村 謙, 堀江 稔, 高橋 正紀, 松村 剛

    臨床神経学   61 ( Suppl. )   S205 - S205   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ

    日本腎臓学会誌   63 ( 4 )   478 - 478   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ

    日本腎臓学会誌   63 ( 4 )   478 - 478   2021年6月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 見かけ上は健康な日本人男性の無症候性大動脈弁石灰化との関連における脂質の標準指標と比較したリポ蛋白粒子のプロファイル(Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men)

    Vu Thien, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Zaid Maryam, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Nakagawa Yoshihisa, Suzuki Tomoaki, Asai Tohru, Miura Katsuyuki, Ueshima Hirotsugu

    Circulation Journal   85 ( 7 )   1076 - 1082   2021年6月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    大動脈弁石灰化(AVC)と核磁気共鳴(NMR)で測定したリポ蛋白粒子との関連について、AVCと脂質の標準指標との関連と比較検討した。リポ蛋白粒子[低比重リポ蛋白(LDL)粒子(nmol/L)および高比重リポ蛋白(HDL)粒子(μmol/L)]と、LDLコレステロール(LDL-C)およびHDLコレステロール(HDL-C)(いずれもmg/dL)について検討した。2006年〜2008年に滋賀県草津市在住者から40〜79歳の日本人男性を無作為に抽出し、1094名が本研究への参加に同意した(参加率46%)。Agatstonスコア>0をAVCありと判定した。リポ蛋白粒子はNMR分光法にて測定した。脂質の第1四分位群に対する第4四分位群のAVCの多変量調整オッズ比(OR)と95%CIを求めた。874例(平均63.3±10.0歳)を解析した。AVCを認めたのは153名であった。第4四分位群のAVCの調整OR(95%CI)は、LDL粒子で2.20(1.23〜3.93)、LDL-Cで2.16(1.23〜3.78)であった。HDL粒子およびHDL-CはAVCと関連がなかった。以上から、NMRで測定したLDL粒子とAVCとの関連は、LDL-CとAVCとの関連と同等であった。

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    その他リンク: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04756&link_issn=&doc_id=20210702370016&doc_link_id=1390851430024624896&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390851430024624896&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

  • Association of Accurately Measured Office, Self-measured Home, and Ambulatory Blood Pressure and Their Variability with Intracranial Arterial Stenosis 査読

    Hisamatsu T, Ohkubo T, Fujiyoshi A, Torii S, Segawa H, Kond K, Kadota A, Takashima N, Shitara S, Arima H, Nakagawa Y, Watanabe Y, Shiino A, Nozaki K, Ueshima H, Miura K

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2021   143 ( Suppl_1 )   2021年5月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

    DOI: 10.1161/circ.143.suppl_1.p096

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  • Factors of Premature Atrial Contractions among General Japanese Men(和訳中)

    Ahmed Sabrina, Miura Katsuyuki, Hisamatsu Takashi, Kadota Aya, Fujiyoshi Akira, Segawa Hiroyoshi, Torii Sayuki, Takashima Naoyuki, Kondo Keiko, Nakagawa Yoshihisa, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   85回   OE083 - 1   2021年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 日本人一般男性における心房期外収縮の原因(Factors of Premature Atrial Contractions among General Japanese Men)

    Ahmed Sabrina, Miura Katsuyuki, Hisamatsu Takashi, Kadota Aya, Fujiyoshi Akira, Segawa Hiroyoshi, Torii Sayuki, Takashima Naoyuki, Kondo Keiko, Nakagawa Yoshihisa, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   85回   OE083 - 1   2021年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連 滋賀動脈硬化疫学研究

    久松 隆史, 大久保 孝義, 藤吉 朗, 鳥居 さゆ希, 瀬川 裕佳, 近藤 慶子, 門田 文, 高嶋 直敬, 設楽 智史, 有馬 久富, 中川 義久, 渡邉 嘉之, 椎野 顯彦, 野崎 和彦, 上島 弘嗣, 三浦 克之

    Journal of Epidemiology   31 ( Suppl. )   89 - 89   2021年1月

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    記述言語:日本語   出版者・発行元:(一社)日本疫学会  

    J-GLOBAL

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米真司, 宮澤伊都子, 門田文, 久松隆史, 近藤慶子, 瀬川裕佳, 鳥居さゆき, 荒木信一, 前川聡, 三浦克之, 上島弘嗣

    日本腎臓学会誌(Web)   63 ( 4 )   2021年

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  • 日本の中学・高校教員におけるインターネット依存と頸部痛のリスクの関連

    田邉 莉奈, 久松 隆史, 福田 茉莉, 土江 梨奈, 鈴木 雅子, 菅谷 渚, 中村 幸志, 高橋 謙造, 神田 秀幸

    日本アルコール・薬物医学会雑誌   55 ( 5 )   95 - 95   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

    J-GLOBAL

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  • 全国高校eスポーツ選手権大会出場校の実態

    神田 秀幸, 田邉 莉奈, 福田 茉莉, 久松 隆史

    日本アルコール・薬物医学会雑誌   55 ( 5 )   90 - 90   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

    J-GLOBAL

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  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率 益田研究

    久松 隆史, 福田 茉莉, 谷口 かおり, 宮川 健, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   79回   339 - 339   2020年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

    J-GLOBAL

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  • Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men(和訳中)

    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   84回   OJ25 - 5   2020年7月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 日本人男性における冠動脈の石灰化で判断した潜在性アテローム硬化進行と腎機能との関連 SESSA研究(The association between kidney function and subclinical atherosclerosis progression evaluated by coronary artery calcification in Japanese men: SESSA study)

    Ganbaatar Namuun, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Miyazawa Itsuko, Kondo Keiko, Salman Ebtehal, Segawa Hiroyoshi, Torii Sayuki, Kume Shinji, Hisamatsu Takashi, Araki Shinichi, Maegawa Hiroshi, Ueshima Hirotsugu

    日本腎臓学会誌   62 ( 4 )   383 - 383   2020年7月

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    記述言語:英語   出版者・発行元:(一社)日本腎臓学会  

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  • 中年期日本人男性におけるApoAI含有LOX-1リガンドの血中レベルと冠動脈石灰化との関連(Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men)

    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   84回   OJ25 - 5   2020年7月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • ある閾値を基準にした空腹時血糖の上昇は非糖尿病者における認知機能の低下と関連している 集団ベース研究(Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study)

    Liu Ziyi, Zaid Maryam, Hisamatsu Takashi, Tanaka Sachiko, Fujiyoshi Akira, Miyagawa Naoko, Ito Takahiro, Kadota Aya, Tooyama Ikuo, Miura Katsuyuki, Ueshima Hirotsugu, the SESSA Research Group

    Journal of Epidemiology   30 ( 3-4 )   121 - 127   2020年4月

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    記述言語:英語   出版者・発行元:(一社)日本疫学会  

    <Highlight>●日本人男性集団において認知機能と空腹時血糖の関連を検討した。●認知機能はCASIで評価した。●糖尿病のない男性では血糖値が3.97-6.20mmol/Lの範囲で認知機能が最も高かった。●糖尿病のある男性では、血糖値が高いほど認知機能が低かった。●血糖値と認知機能との関連は糖尿病の有無により異なっていた。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J04763&link_issn=&doc_id=20200423300003&doc_link_id=10.2188%2Fjea.JE20180193&url=https%3A%2F%2Fdoi.org%2F10.2188%2Fjea.JE20180193&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 山陰地方の中学・高校教職員におけるインターネット利用状況の実態

    神田 秀幸, 福田 茉莉, 土江 梨奈, 津村 秀樹, 久松 隆史

    産業衛生学雑誌   62 ( 2 )   108 - 108   2020年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    J-GLOBAL

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  • Relationship of four blood pressure indexes to subclinical cerebrovascular diseases assessed by brain MRI in general Japanese men 査読

    Salman E, Kadota A, Hisamatsu T, Segawa H, Torii S, Fujiyoshi A, Kondo K, Arima H, Shiino A, Nozaki K, Miura K, Ueshima H

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2020   29 ( 2 )   174 - 187   2020年3月

  • The relationship between alcohol drinking before sleeping (Ne-Zake) or in the morning (Mukae-Zake) and sleeplessness among farmers 査読

    Sato R, Hisamatsu T, Tsumura H, Fukuda M, Esumi Y, Mikajiri K, Tamura S, Kanda H

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2020   141   2020年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:記事・総説・解説・論説等(国際会議プロシーディングズ)  

    DOI: 10.1161/circ.141.suppl_1.P547

    Web of Science

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  • Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).

    FUSE Keiko, KADOTA Aya, KONDO Keiko, MORINO Katsutaro, FUJIYOSHI Akira, HISAMATSU Takashi, KADOWAKI Sayaka, MIYAZAWA Itsuko, UGI Satoshi, MAEGAWA Hiroshi, MIURA Katsuyuki, UESHIMA Hirotsugu, SESSA Research Group, 布施 恵子, 門田 文, 近藤 慶子, 森野 勝太郎, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣

    Diabetes research and clinical practice   ( 160 )   108002 - 108002   2020年1月

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    記述言語:英語   出版者・発行元:Elsevier Scientific Publishers  

    METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models.

    CiNii Article

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  • 「健康診査・保健指導における健診項目等の必要性,妥当性の検証,及び地域における健診実施体制の検討のための研究」8.コホート研究での実証:滋賀動脈硬化疫学研究(SESSA)における上下肢血圧比(ABI,Ankle Brachial Index)/脈波伝播速度(PWV,Pulse Wave Velocity)と冠動脈石灰化との関連

    三浦克之, 久松隆史, 藤吉朗, 門田文, 上島弘嗣

    健康診査・保健指導における健診項目等の必要性、妥当性の検証、及び地域における健診実施体制の検討のための研究 令和元年度 総括・分担研究報告書(Web)   2020年

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  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田茉莉, 中畑典子, 神田秀幸, 神田秀幸

    日本疫学会学術総会講演集(Web)   30th   2020年

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  • IoTを活用した長期家庭血圧管理研究の実践報告と課題 益田研究(第1報)

    福田 茉莉, 中畑 典子, 宮川 健, 谷口 かおり, 久松 隆史, 神田 秀幸

    日本公衆衛生学会総会抄録集   78回   330 - 330   2019年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

    J-GLOBAL

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  • 家庭血圧測定実施者における食習慣と食物摂取状況の変化 益田研究(第2報)

    中畑 典子, 福田 茉莉, 宮川 健, 谷口 かおり, 久松 隆史, 神田 秀幸

    日本公衆衛生学会総会抄録集   78回   330 - 330   2019年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

    J-GLOBAL

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  • 勤労者における測定環境室温と家庭血圧値の変動に関する横断研究 益田研究より

    神田 秀幸, 福田 茉莉, 中畑 典子, 宮川 健, 谷口 かおり, 久松 隆史

    日本高血圧学会総会プログラム・抄録集   42回   375 - 375   2019年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

    J-GLOBAL

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松 隆史, 三浦 克之, 大久保 孝義, 門田 文, 近藤 慶子, 喜多 義邦, 早川 岳人, 神田 秀幸, 岡村 智教, 岡山 明, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   42回   302 - 302   2019年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 現代の我が国の一般地域住民における家庭血圧の現状 Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山 敬, 田原 康玄, 大石 絵美, 坂田 智子, 久松 隆史, 呉代 華容, 樺山 舞, 辰巳 友佳子, 秦 淳, 菊谷 昌浩, 神出 計, 三浦 克之, 二宮 利治, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集   42回   293 - 293   2019年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連 SESSA

    宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣

    肥満研究   25 ( Suppl. )   250 - 250   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本肥満学会  

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  • 冠動脈石灰化と無症候性脳血管疾患の相関性 コミュニティベース研究(The Association Between Coronary Artery Calcium and The Subclinical Cerebrovascular Disease: A Community Based Study)

    Khan Md Maruf Haque, Fujiyoshi Akira, Miura Katsuyuki, Hisamatsu Takashi, Torii Sayuki, Suzuki Sentaro, Shiino Akihiko, Nozaki Kazuhiko, Ohkubo Takayoshi, Kunimura Ayako, Ueshima Hirotsugu

    日本動脈硬化学会総会プログラム・抄録集   51回   2 - 2   2019年7月

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    記述言語:英語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 一般日本人女性における受動喫煙状態と血管内皮機能との関連(Association of Passive Smoking Status to Endothelial Vascular Function among General Japanese Women)

    門田 文, 近藤 慶子, 久松 隆史, 宮澤 伊都子, 藤吉 朗, 上島 弘嗣, 三浦 克之

    日本循環器学会学術集会抄録集   83回   PJ041 - 4   2019年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 現代の我が国の一般地域住民における家庭血圧の現状:Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山敬, 田原康玄, 大石絵美, 坂田智子, 久松隆史, 呉代華容, 樺山舞, 辰巳友佳子, 秦淳, 菊谷昌浩, 神出計, 三浦克之, 二宮利治, 大久保孝義

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   293 - 293   2019年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

    J-GLOBAL

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連:SESSA

    宮澤伊都子, 大久保孝義, 村上陽子, 永谷幸裕, 佐藤滋高, 藤吉朗, 藤吉朗, 久松隆史, 門田文, 門脇紗也佳, 瀬川裕佳, 近藤慶子, 新田哲久, 前川聡, 三浦克之, 三浦克之, 上島弘嗣

    日本肥満学会・日本肥満症治療学会合同学術集会プログラム・抄録集   40th-37th ( Suppl. )   250 - 250   2019年

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    記述言語:日本語   出版者・発行元:(一社)日本肥満学会  

    J-GLOBAL

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  • 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 NIPPON DATA2010実行ワーキンググループ報告

    大久保孝義, 宮本恵宏, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 大澤正樹, 東山綾, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 平成30年度 総括・分担研究報告書(Web)   2019年

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  • The Ratio of Liver to Spleen (L/S Ratio) for CT Attenuation Value Is Associated with the Onset of Diabetes Mellitus in a Community-Based Sample of Japanese Men-The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    Keiko Fuse, Aya Kadota, Keiko Kondo, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Itsuko Miyazawa, Katsutaro Morino, Osamu Sekine, Satoshi Ugi, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

    DIABETES   67   2018年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-1636-P

    Web of Science

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  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下 SESSA研究

    宮川 尚子, 大久保 孝義, 藤吉 朗, 斎藤 祥乃, 久松 隆史, 門田 文, 関川 暁, 三浦 克之, 上島 弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤 慶子, 有馬 久富, 岡見 雪子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 森野 勝太郎, 前川 聡, 三浦 克之, 上島 弘嗣, 滋賀動脈硬化疫学研究(SESSA)グループ

    糖尿病   61 ( Suppl.1 )   S - 157   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究

    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ

    糖尿病   61 ( Suppl.1 )   S - 293   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究

    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ

    糖尿病   61 ( Suppl.1 )   S - 293   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population 査読

    Miyagawa Naoko, Arima Hisatomi, Yoshita Katsushi, Okuda Nagako, Ohkubo Takayoshi, Hisamatsu Takashi, Kondo Keiko, Miura Katsuyuki

    CIRCULATION   137   2018年3月

  • Objectively Measured Step Counts Was Independently Associated With Higher Cognition in Apparently Healthy Japanese Men 査読

    Shibukawa Takeshi, Fujiyoshi Akira, Miura Katsuyuki, Miyagawa Naoko, Saito Yoshino, Zaid Maryam, Hisamatsu Takashi, Ohkubo Takayoshi, Arima Hisatomi, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   137   2018年3月

  • 日本人男性の一般集団における腸内微生物叢と冠動脈石灰化 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Gut Microbiota and Coronary Artery Calcification in a General Population of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))

    有馬 久富, 近藤 慶子, 岡見 雪子, 藤 吉朗, 門田 文, 高嶋 直敬, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ12 - 6   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    J-GLOBAL

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  • 日本人一般集団における血清N-3 polyunsaturated fatty acidと高感度C反応性蛋白の関連性(Association of Serum N-3 Polyunsaturated Fatty Acids and High-sensitivity C-reactive Protein in Japanese General Population)

    中村 翼, 門田 文, 近藤 慶子, 宮川 尚子, 関川 暁, 藤 吉朗, 久松 隆史, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ24 - 7   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • QT延長症候群1型の変異特異的リスク層別化における課題(A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1)

    八木 典章, 伊藤 英樹, 久松 隆史, 大野 聖子, 堀江 稔

    日本循環器学会学術集会抄録集   82回   PJ046 - 3   2018年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1(和訳中)

    八木 典章, 伊藤 英樹, 久松 隆史, 大野 聖子, 堀江 稔

    日本循環器学会学術集会抄録集   82回   PJ046 - 3   2018年2月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

    DOI: 10.1016/j.jjcc.2017.12.011

    PubMed

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  • The Association Between Coronary Artery Calcium And Cerebral Small Vessel Disease: A Population Based Cross Sectional Study 査読

    Khan Md, Maruf Haque, Fujiyoshi Akira, Miura Katsuyuki, Hisamatsu Takashi, Torii Sayuki, Suzuki Sentaro, Shiino Akihiko, Nozaki Kazuhiko, Ohkubo Takayoshi, Ueshima Hirotsugu

    STROKE   49   2018年1月

  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下:SESSA研究

    宮川尚子, 大久保孝義, 藤吉朗, 斎藤祥乃, 久松隆史, 門田文, 関川暁, 三浦克之, 上島弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

    J-GLOBAL

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  • 一般住民男性における無症候性頭蓋内血管性病変と認知機能との関連:滋賀動脈硬化疫学研究SESSA

    伊藤隆洋, 藤吉朗, 大久保孝義, 椎野顕彦, 野崎和彦, 宮川尚子, 鳥居さゆ希, 久松隆史, 三浦克之, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   189 - 189   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    J-GLOBAL

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  • 地域住民一般男性における筋肉面積,脂肪筋面積と年齢や体格との関連の検討:SESSA/ERA-JUMP横断研究

    藤吉朗, 門脇紗也佳, 東宏一郎, 門田文, 門田文, 近藤慶子, 久松隆史, 国村彩子, 関川暁, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   199 - 199   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    J-GLOBAL

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  • 日本人一般住民男性における腸内細菌と血清LDLコレステロールとの関連:SESSA研究

    岡見雪子, 有馬久富, 近藤慶子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   178 - 178   2018年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    J-GLOBAL

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 イベント判定委員会報告(ND2010イベント判定委員会)

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 門田文, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)   2018年

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連:滋賀動脈硬化疫学研究

    布施恵子, 布施恵子, 門田文, 門田文, 近藤慶子, 藤吉朗, 久松隆史, 久松隆史, 門脇紗也佳, 宮澤伊都子, 森野勝太郎, 関根理, 卯木智, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤慶子, 有馬久富, 岡見雪子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 森野勝太郎, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018年

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  • 日本人男性の地域在住被験者における喫煙と関連する冠動脈硬化性の高発症率および進行度 The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))

    Pham Tai, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Kadowaki Sayaka, Zaid Maryam, Horie Minoru, Miura Katsuyuki, Ueshima Hirotsugu, for the SESSA Research Group

    日本アルコール・薬物医学会雑誌   52 ( 4 )   239 - 239   2017年8月

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    記述言語:英語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連 滋賀動脈硬化疫学研究SESSA

    久松 隆史, 三浦 克之, 有馬 久富, 門田 文, 門脇 紗也佳, 鳥居 さゆ希, 鈴木 仙太朗, 宮川 尚子, 佐藤 敦, 藤吉 朗, 大久保 孝義, アボット・ロバート, 関川 暁, 堀江 稔, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   49回   112 - 112   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study 査読

    Fujiyoshi Akira, Ohkubo Takayoshi, Miura Katsuyuki, Shiino Akihiko, Miyagawa Naoko, Takashima Naoyuki, Saitoh Yoshino, Torii Sayuki, Kadota Aya, Kadowaki Sayaka, Hisamatsu Takashi, Miyazawa Itsuko, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   135   2017年3月

  • Prevalence Of Intracranial Artery Stenosis and the Association With Conventional Risk Factors of Cardiovascular Diseases in a General Population of Japanese: SESSA Study

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Torii Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION   135   2017年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • Risk Factors for the Progression and Incidence of Aortic Calcification in an International Multi-ethnic Cohort of Men Aged 40-49 Years: ERA JUMP Study

    Siyi Shangguan, Jingchuan Guo, Hemant Mahajan, Kamal Masaki, Bradly J. Willcox, Katsuyuki Miura, Hirotsugu Ueshima, Akira Fujiyoshi, Takashi Hisamatsu, Lewis H. Kuller, Emma J. Barinas-Mitchell, Daniel Edmundowicz, Akira Sekikawa

    CIRCULATION   135   2017年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連 地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    久松 隆史, 三浦 克之, 渋川 武志, 藤吉 朗, 有馬 久富, 門田 文, 宮川 尚子, 鳥居 さゆ希, 近藤 慶子, 宮澤 伊都子, 鈴木 仙太朗, 佐藤 敦, 山添 正博, 柳田 昌彦, 前川 聡, 上島 弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017年3月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    【背景】客観的に評価された身体活動量がメタボリックシンドローム(MetS)発症リスクと関連するかどうか検討した研究はほとんどない。【目的】日本人一般住民男性において、歩数計を用いて評価された歩数値とMetS新規発症との関連を縦断的に検討すること。【方法】滋賀県草津市住民から無作為抽出された40-79歳男性のうちMetSを有さない525名(平均年齢64.1±9.6歳)を対象とし、5年間の前向きコホート研究(基礎調査2006-8年)を実施した。歩数は基礎調査時に土・日曜日を含む7日間連続で歩数計を用いて測定し1日平均値を求めた。MetS発症の診断は日本基準を用いて評価した。ロジスティック回帰を用いてMetS新規発症に対する歩数値に関する多変量調整相対リスク(RR)および95%信頼区間(CI)を算出した。【結果】平均追跡期間4.8±1.3年を経て、MetS新規発症者は77名(14.7%)であった。Body mass indexを含む交絡因子を調整後も歩数値とMetS発症との間に負の関連を認めた。この関連はMetS各構成要素でさらに調整しても変わらなかった(最低三分位群[5,792歩未満]と比較して、最高三分位群[10,033歩以上]のMetS発症に対するRR(95%CI)は0.34[0.17-0.72])。また、MetS発症に対する1日平均1,000歩増加あたりのRR(95%CI)は、0.87(0.78-0.96)であった。65歳未満・以上、MetS各構成要素の有無で層別に解析したが同様の傾向を認めた(全異質性P値>0.3)。【結語】MetSの好発集団とされる一般中高年男性において、客観的に評価された歩数値はMetS発症と有意な負の関連を示した。また、1日平均歩数値1,000歩増加あたりMetS発症リスクが13%低下した。本成果は健康日本21(第二次)の歩数目標値や身体活動基準2013を支持する結果である。(著者抄録)

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  • 日常的歩行運動レベルが左心房拡大,心房細動発症に与える影響-地域住民7年追跡研究-

    山添正博, 久松隆史, 大野聖子, 有馬久富, 三浦克之, 上島弘嗣

    若手研究者のための健康科学研究助成成果報告書   ( 32 )   108 - 113   2017年

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    記述言語:日本語   出版者・発行元:(公財)明治安田厚生事業団  

    草津市に在住する40〜79歳の一般男性から無作為抽出した983名を対象とし、歩数計で測定した日常的歩行運動レベルと左心房拡大との関連について7年間の追跡調査を行った。歩数を含む諸因子を独立変数として重回帰分析を行った。その結果、左心房拡大に関連する独立した因子の一つとして「歩数の増加」が抽出された。

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連:滋賀潜在性動脈硬化研究(SESSA)

    宮澤伊都子, 大久保孝義, 藤吉朗, 久松隆史, 門田文, 村上陽子, 永谷幸裕, 門脇紗也佳, 村田喜代史, 前川聡, 三浦克之, 三浦克之, 上島弘嗣

    日本循環器病予防学会誌   52 ( 2 )   201 - 201   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討:パイロット研究

    宮川尚子, 有馬久富, 由田克士, 奥田奈賀子, 大久保孝義, 久松隆史, 近藤慶子, 三浦克之

    日本循環器病予防学会誌   52 ( 2 )   171 - 171   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連:滋賀動脈硬化疫学研究SESSA

    炭昌樹, 久松隆史, 久松隆史, 藤吉朗, 門田文, 門田文, 宮川尚子, 近藤慶子, 門脇紗也佳, 鈴木仙太朗, 鳥居さゆ希, 鳥居さゆ希, MARYAM Zaid, 佐藤敦, 有馬久富, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 2 )   183 - 183   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    J-GLOBAL

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 NIPPON DATA2010イベント判定委員会

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)   21‐24 (WEB ONLY)   2017年

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    記述言語:日本語  

    J-GLOBAL

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  • 一般地域男性住民における高い睡眠呼吸障害有所見率とその要因-SESSA研究-

    高嶋直敬, 久松隆史, 鳥居さゆ希, 佐藤敦, 宮川尚子, 門田文, 門田文, 有馬久富, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣

    日本疫学会学術総会講演集(Web)   27th   150 (WEB ONLY)   2017年

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    記述言語:日本語  

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 門田文, 門脇紗也佳, 鳥居さゆ希, 鈴木仙太朗, 宮川尚子, 佐藤敦, 藤吉朗, 大久保孝義, アボット ロバート, 関川暁, 堀江稔, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   112 (WEB ONLY) - 112   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較,及びその差に影響を及ぼす要因の検討:滋賀動脈硬化疫学研究(SESSA)

    門脇紗也佳, 寳澤篤, 藤吉朗, 久松隆史, 佐藤敦, 田中佐智子, 岡村智教, 大久保孝義, 三浦克之, 三浦克之, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   40th   408 - 408   2017年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

    J-GLOBAL

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  • 非肥満者に対する保健指導方法の開発に関する研究 非肥満者を含む集団への生活習慣に関する介入研究の文献レビュー

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  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    近藤慶子, 有馬久富, 久松隆史, 藤吉朗, 門田文, 関川暁, 鳥居さゆ希, 鈴木仙太朗, 椎野顯彦, 野崎和彦, 宮川尚子, 前川聡, 村田喜代史, 三浦克之, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   195 - 195   2017年

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    記述言語:日本語   出版者・発行元:(一社)日本動脈硬化学会  

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  • Comparison of anthropometric measures of obesity in the association with coronary artery calcification in the general Japanese population

    Y. Sugimoto, T. Hisamatsu, K. Miura, S. Kadowaki, A. Kadota, M. Zaid, S. Torii, N. Miyagawa, A. Satoh, Y. Saitoh, M. Yamazoe, H. Arima, A. Fujiyoshi, A. Sekikawa, H. Ueshima

    EUROPEAN HEART JOURNAL   37   546 - 546   2016年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS  

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  • Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition? 査読

    Satoh Atsushi, Arima Hisatomi, Hozawa Atsushi, Hisamatsu Takashi, Kadowaki Sayaka, Kadota Aya, Fujiyoshi Akira, Miyagawa Naoko, Zaid Maryam, Torii Sayuki, Ohkubo Takayoshi, Okamura Tomonori, Sekikawa Akira, Miura Katsuyuki, Ueshima Hirotsugu

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  • Significant Inverse Association of Blood Levels of Marine Omega-3 Fatty Acids with Coronary Artery Calcification in Men in Japan

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    CIRCULATION   133   2016年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Re-evaluation of Prognostic Values of Clockwise and Counterclockwise Rotation for Total and Cardiovascular Mortality in a Different Cohort (20 Year Follow-up of NIPPON DATA90)

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    CIRCULATION   133   2016年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome in a General Population

    Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Akira Fujiyoshi, Robert Abbott, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Hone, Hirotsugu Ueshima

    CIRCULATION   133   2016年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Significant Positive Association of Progression in Arterial Stiffness with Accelerated Increase in Aortic Calcification Among Multi-ethnic Middle-aged Men (ERA JUMP Study)

    Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Vishnu Abhishek, Emma Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Bradley Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

    CIRCULATION   133   2016年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 一般集団においてinsulin抵抗性はメタボリックシンドロームよりも冠動脈石灰化の有病率および進行に関連する(Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification beyond Metabolic Syndrome in a General Population)

    Yamazoe Masahiro, Hisamatsu Takashi, Miura Katsuyuki, Kadowaki Sayaka, Zaid Maryam, Fujiyoshi Akira, Kadowaki Takashi, Abbott Robert, Arima Hisatomi, Sekikawa Akira, Maegawa Hiroshi, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   80 ( Suppl.I )   2036 - 2036   2016年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 日本人男性における心臓周囲脂肪量の縦断的変化の予測因子とは 滋賀動脈硬化疫学研究(SESSA)(Which Factors Predict Longitudinal Change of Pericardial Fat Volume in Japanese Men? The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA))

    Miyazawa Itsuko, Ohkubo Takayoshi, Kadowaki Sayaka, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Arima Hisatomi, Miura Katsuyuki, Maegawa Hiroshi, Ueshima Hirotsugu

    Circulation Journal   80 ( Suppl.I )   823 - 823   2016年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   117   2016年1月

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    記述言語:日本語  

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  • 睡眠時間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究(SESSA)

    鈴木仙太朗, 有馬久富, 有馬久富, 宮崎総一郎, 藤吉朗, 門田文, 門田文, 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 門脇紗也佳, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   121   2016年1月

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    記述言語:日本語  

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  • 日本人一般住民における肥満指標と冠動脈石灰化との関連の比較検討

    杉本裕子, 久松隆史, 三浦克之, 門脇紗也佳, 門田文, MARYAM Zaid, 鳥居さゆ希, 鳥居さゆ希, 宮川尚子, 佐藤敦, 斎藤祥乃, 山添正博, 有馬久富, 藤吉朗, 関川暁, 上島弘嗣

    日本循環器学会近畿地方会(Web)   121st   KINKI121,D07 (WEB ONLY)   2016年

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    記述言語:日本語  

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討:パイロット研究

    宮川尚子, 有馬久富, 由田克士, 奥田奈賀子, 大久保孝義, 久松隆史, 近藤慶子, 岡見雪子, 三浦克之

    日本循環器病予防学会誌   51 ( 2 )   114 - 114   2016年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 飲酒はLDLコレステロール濃度とLDL粒子数を減らす~メンデルランダム化解析

    田原康玄, 上島弘嗣, 高嶋直敬, 久松隆史, 藤吉朗, ZAID Maryam, 炭昌樹, 小原克彦, 三木哲郎, 三浦克之

    日本循環器病予防学会誌   51 ( 2 )   139 - 139   2016年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 客観的に評価された歩数値とメタボリック症候群発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    久松隆史, 久松隆史, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 上島弘嗣

    日本循環器病予防学会誌   51 ( 2 )   120 - 120   2016年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   2016年

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  • 睡眠時間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究(SESSA)

    鈴木仙太朗, 有馬久富, 有馬久富, 宮崎総一郎, 藤吉朗, 門田文, 門田文, 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 門脇紗也佳, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   2016年

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  • THE ASSOCIATION OF BRACHIAL-ANKLE PULSE WAVE VELOCITY AND ESTIMATED GLOMERULAR FILTRATION RATE WITH ALBUMINURIA AMONG GENERAL JAPANESE

    A. Kadota, K. Miura, T. Ohkubo, T. Hisamatsu, A. Fujiyoshi, N. Takashima, T. Okamura, H. Ueshima

    ATHEROSCLEROSIS   241 ( 1 )   E130 - E130   2015年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • THE ASSOCIATION BETWEEN VASCULAR RISK FACTORS AND OVER ACTIVE BLADDER

    Teruhiko Tsuru, Isao Araki, Sayaka Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Akihiro Kawauchi, Katsuyuki Miura, Hirotsugu Ueshima

    JOURNAL OF UROLOGY   193 ( 4 )   E302 - E303   2015年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER SCIENCE INC  

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  • 滋賀医科大学アジア疫学研究センターの取り組み NCD克服のための疫学研究・教育拠点を目指して

    三浦 克之, 堀江 稔, 野崎 和彦, 久松 隆史, Abbott Robert D.

    滋賀医科大学看護学ジャーナル   13 ( 1 )   8 - 14   2015年3月

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    記述言語:日本語   出版者・発行元:滋賀医科大学  

    滋賀医科大学では2013年10月に、新しい総合研究棟(疫学研究拠点)としてアジア疫学研究センターが新築、開所した。本センターは、本学のこれまでの生活習慣病疫学研究の実績を生かし、良好な研究環境による国際共同疫学研究の実施、大規模データベースの管理とバイオバンクによる生体試料保存を行うことを可能にするものである。また、これと時期を同じくして、文部科学省の平成25年度博士課程教育リーディングプログラムが採択され、アジア疫学研究センターを教育基盤とした博士課程教育リーディングプログラム「アジア非感染性疾患(NCD)超克プロジェクト」が開始された。本プログラムでは国内外の産学官の広い分野においてアジア太平洋州のトップリーダーとして活躍するNCD対策の専門家を育成する。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J04402&link_issn=&doc_id=20150416340002&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10422%2F9294&url=http%3A%2F%2Fhdl.handle.net%2F10422%2F9294&type=%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%81F%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%8B%40%8A%D6%83%8A%83%7C%83W%83g%83%8A%82%D1%82%ED%8C%C9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80165_3.gif

  • 一般日本人集団における主要および軽微なECG異常の無症候性アテローム硬化との関連性 SESSA(Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA)

    Hisamatsu Takashi, Miura Katsuyuki, Fujiyoshi Akira, Kadowaki Sayaka, Zaid Maryam, Torii Sayuki, Kadota Aya, Nakamura Yasuyuki, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   79 ( Suppl.I )   2059 - 2059   2015年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 日本人男性におけるhigh-density lipoprotein粒子濃度と頸動脈の無症候性アテローム性動脈硬化症との関連性(The Association of High-density Lipoprotein Particle Concentration with Subclinical Atherosclerosis of the Carotid Arteries in Japanese Men)

    Zaid Maryam, Fujiyoshi Akira, Miura Katsuyuki, Abbott Robert D., Okamura Tomonori, Takashima Naoyuki, Torii Sayuki, Saito Yoshino, Hisamatsu Takashi, Miyagawa Naoko, Ohkubo Takayoshi, Kadota Aya, Sekikawa Akira, Maegawa Hiroshi, Nakamura Yasuyuki, Mitsunami Kenichi, Ueshima Hirotsugu

    Circulation Journal   79 ( Suppl.I )   634 - 634   2015年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • 家庭血圧は理想的環境下で測定した診察室血圧より冠動脈石灰化と強く関連するか?:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    佐藤敦, 有馬久富, 有馬久富, 寳澤篤, 久松隆史, 久松隆史, 門田文, 門田文, 藤吉朗, 宮川尚子, ZAID Maryam, 鳥居さゆ希, 大久保孝義, 岡村智教, 関川暁, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   38th   397 - 397   2015年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 水銀血圧計使用中止に伴う代替測定法の検討

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    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成26年度 総括・分担研究報告書   2015年

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  • non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 一般住民におけるnon-HDL-Cの長期冠動脈疾患予測能および,潜在性冠動脈硬化との関連の検討

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    non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 平成26年度 総括・分担研究報告書   2015年

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  • non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 Non-HDLコレステロールの臨床的意義に関する文献レビュー

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 身体状況調査会場に来場した対象者における血圧測定精度の検討

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  • Modified LDL (serum level of LOX-1 ligand containing ApoB) was associated with increased carotid intima-media thickness in Japanese community dwelling men especially with hypercholesterolemia

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  • Transferrin saturation and risk for cardiovascular mortality: a 20-year follow-up

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  • 【colitic cancerの初期病変-遡及例の検討を含めて】内視鏡検査からみたcolitic cancerの初期病変 拡大内視鏡所見を中心に

    岩男 泰, 下田 将之, 杉野 吉則, 浦岡 俊夫, 吉田 諭史, 井上 詠, 小林 拓, 松岡 克善, 長沼 誠, 久松 理一, 緒方 晴彦, 金井 隆典, 長谷川 博俊, 三上 修治, 亀山 香織, 八尾 隆史

    胃と腸   49 ( 10 )   1464 - 1478   2014年9月

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    【背景と目的】UC関連癌は早期の診断が困難なため,進行癌で発見され予後が不良なことが多い.初期病変である粘膜内腫瘍(pTis癌,HGD)を対象に,拡大観察を含めた内視鏡像を解析し,早期発見につながる所見を見い出す.【対象と方法】当院で診療したUC関連腫瘍を対象とし,特に粘膜内腫瘍21症例27病変を抽出して以下の検討を行った.(1)pT1以深の症例との臨床病理学的比較検討.(2)拡大内視鏡観察を中心とした内視鏡所見の解析と病理組織像との対比.【結果】(1)pT1以深の病変と比し,臨床背景に差はないが,有意に主病変の大きさが小さく,分化度が高かった.(2)pTis癌・HGDのうち平坦型,平坦病変を主体とする病変が33.3%を占め,いずれも発赤領域として認識された.陥凹型は1病変あり,低分化型腺癌であった.(3)全病変で腫瘍性pit patternの診断が可能であり,IVV型pit patternが全体の56.5%にみられ,平坦型病変の71.4%が管状pit,陥凹型病変はVN型を呈した.(4)腫瘍・非腫瘍の鑑別はpit pattern観察およびNBI拡大観察ともに全病変で可能であった.(5)癌・HGDの鑑別は絨毛状の表面構造を呈する病変では限界があった.【結論】UC関連pTis癌・HGDの40%近くが平坦型病変であり,発赤領域として認識される.pit patternはIVV型の頻度が高いが,平坦型に限ると管状pitが約70%を占める.拡大観察では,表面構造が絨毛形態を示す病変における癌・dysplasiaの鑑別診断能には限界があるが,周囲粘膜との比較において腫瘍・非腫瘍の鑑別診断は可能である.以上,領域のある発赤に注意し,積極的な拡大観察を行うことが,初期病変である平坦型病変の発見に寄与する可能性が示唆された.(著者抄録)

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  • J波症候群と関連する電気的障害 日本人集団における早期再分極 日本における循環器疾患基礎調査(NIPPON DATA)からの新たな知見(J-wave Syndrome and Related Electrical Disorders Early Repolarization in Japanese General Population: New Findings from the National Surveys of Circulatory Disorders of Japan (NIPPON DATA))

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu

    Circulation Journal   78 ( Suppl.I )   115 - 115   2014年3月

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    記述言語:英語   出版者・発行元:(一社)日本循環器学会  

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  • Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • Relationship Of Plasma Asymmetrical Dimethylarginine To Carotid Intima-media Thickness In General Japanese Population: The ERA-JUMP And The SESSA.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014年

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  • Brachial-ankle Pulse Wave Velocity is Independently Associated with Presence of Coronary Calcification among 1131 Healthy Middle-aged Men. The ERA JUMP Study.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 1.NIPPON DATA80 リスクチャートを用いた冠動脈死亡絶対危険度,動脈硬化学会脂質管理カテゴリーと頸部動脈硬化所見との関連の検討

    門田文, 三浦克之, 岡村智教, 藤吉朗, 大久保孝義, 門脇崇, 高嶋直敬, 久松隆史, 中村保幸, 笠置文善, 前川聡, 柏木厚典, 上島弘嗣

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   133 - 134   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 10.日本人一般男性において長鎖n3脂肪酸の高摂取は心疾患死亡リスクにおける安静的心拍数上昇の影響を減弱させる

    久松隆史, 三浦克之, 大久保孝義, 山本孝, 藤吉朗, 宮川尚子, 門田文, 高嶋直敬, 奥田奈賀子, 由田克士, 喜多義邦, 村上義孝, 中村保幸, 堀江稔, 岡村智教, 岡山明, 上島弘嗣

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   218 - 219   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 24.日本人一般住宅における早期再分極:日本循環器疾患基礎調査からの新たな知見

    久松隆史, 三浦克之, 大久保孝義, 岡村智教, 岡山明, 上島弘嗣

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   265 - 266   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 7.日本人一般男性における心疾患死亡リスクに対する早期再分極とn-3不飽和脂肪酸摂取量との交互作用の検討

    久松隆史, 三浦克己, 大久保孝義, 山本孝, 藤吉朗, 宮川尚子, 門田文, 高嶋直敬, 奥田奈賀子, 松村康弘, 由田克士, 喜多義邦, 村上義孝, 中村保幸, 堀江稔, 岡村智教, 岡山明, 上島弘嗣

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   186 - 187   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 3.日本人の血糖値,糖尿病有病率・治療率の30年間の推移の検討

    大西浩文, 大久保孝義, 門田文, 藤吉朗, 古屋好美, 田中英夫, 平田匠, 久松隆史, 佐藤敦, 櫻井勝, 斎藤重幸, 坂田清美, 上島弘嗣, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   116 - 126   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 9.日本人における長鎖n-3不飽和脂肪酸摂取と循環器疾患死亡リスクの関連

    宮川尚子, 三浦克之, 奥田奈賀子, 門脇崇, 高嶋直敬, 長澤晋哉, 中村保幸, 松村康弘, 寳澤篤, 藤吉朗, 久松隆史, 由田克士, 関川暁, 大久保孝義, ABBOTT Robert D., 岡村智教, 岡山明, 上島弘嗣

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   210 - 211   2014年

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 3.NIPPON DATA80/90/2010における心電図の解析について

    岡村智教, 中村好一, 斎藤重幸, 中村保幸, 渡邉至, 中村幸志, 香坂俊, 東山綾, 鳥居さゆ希, 澤野充明, 杉山大典, 久松隆史, 中村美詠子, 田原明子, 三浦克之, 豊嶋英明, 樗木晶子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   25 - 32   2014年

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 血圧測定における自動血圧計の導入に関する課題および提言

    三浦克之, 三浦克之, 久松隆史, 久松隆史, 上島弘嗣, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成25年度 総括・分担研究報告書   2014年

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  • 動脈硬化指標と過活動膀胱との関連についての検討:滋賀動脈硬化疫学研究(SESSA)より

    水流輝彦, 荒木勇雄, 門脇沙也佳, 久松隆史, 久松隆史, 藤吉朗, 河内明宏, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本排尿機能学会誌   25 ( 1 )   153 - 153   2014年

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    記述言語:日本語   出版者・発行元:(一社)日本排尿機能学会  

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  • 高齢男性における過活動膀胱と動脈硬化指標との関係:滋賀動脈硬化疫学研究から

    水流輝彦, 荒木勇雄, 河内明宏, 門脇紗也佳, 久松隆史, 藤吉朗, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本泌尿器科学会総会プログラム抄録集(CD-ROM)   102nd   423 - 423   2014年

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会総会事務局  

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 4.高血圧の有無による心電図所見の検討

    鳥居さゆ希, 岡村智教, 香坂俊, 澤野充明, 久松隆史, 東山綾, 渡邉至, 中村保幸

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   2014年

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  • 炎症性腸疾患診療における内視鏡検査の意義 長期予後の観点からみたクローン病粘膜治癒の検討

    三枝 慶一郎, 長沼 誠, 清野 隆史, 森 清人, 南木 康作, 武下 達矢, 中里 圭宏, 水野 慎大, 高林 馨, 佐藤 俊朗, 松岡 克善, 矢島 知治, 久松 理一, 井上 詠, 岩男 泰, 緒方 晴彦, 金井 隆典

    Progress of Digestive Endoscopy   84 ( Suppl. )   s70 - s70   2013年12月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会-関東支部  

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  • The Relationship of Serum Marine-Derived N-3 Fatty Acids and Carotid Intima-Media Thickness among General Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) 査読

    Kadota Aya, Sekikawa Akira, Miura Katsuyuki, Okamura Tomonori, Fujiyoshi Akira, Kadowaki Takashi, Barinas-Mitchell Emma, Evans Rhobert W, Ohkubo Takayoshi, Hisamatsu Takashi, Miyagawa Naoko, Nakamura Yasuyuki, Maegawa Hiroshi, Kashiwagi Atsunori, Ueshima Hirotsugu

    CIRCULATION   127 ( 12 )   2013年3月

  • High-density Lipoprotein Particle Concentration is Independently Associated with Carotid Intima-media Thickness in Japanese Men 査読

    Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Tomonori Okamura, Takashima Naoyuki, Sayuki Torii, Yoshino Saito, Hisamatsu Takashi, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima

    CIRCULATION   127 ( 12 )   2013年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 長鎖n-3系脂肪酸の食事による高摂取は心血管疾患死亡リスクに関係する安静時心拍数増加の影響を軽減させる(Higher Dietary Long-chain n-3 Fatty Acids Attenuated the Effect of Higher Resting Heart Rate on the Risk of Cardiovascular Mortality)

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Yamamoto Takashi, Miyagawa Naoko, Fujiyoshi Akira, Kadota Aya, Takashima Naoyuki, Okuda Nagako, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Okayama Akira, Ueshima Hirotsugu

    Circulation Journal   77 ( Suppl.I )   259 - 260   2013年3月

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  • 一般日本人集団において非HDLコレステロールは冠動脈石灰化と強く関連する SESSA(Non-HDL Cholesterol is Strongly Associated with Coronary Artery Calcification in a General Japanese Population: SESSA)

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Fujiyoshi Akira, Kadota Aya, Kadowaki Sayaka, Yamamoto Takashi, Miyagawa Naoko, Torii Sayuki, Saitoh Yoshino, Takashima Naoyuki, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   77 ( Suppl.I )   123 - 123   2013年3月

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  • 日本人男性における心臓周囲脂肪と肥満指標との関連:滋賀潜在性動脈硬化研究(SESSA)

    宮澤伊都子, 大久保孝義, 三浦克之, 藤吉朗, 門脇紗也佳, 宮川尚子, 高嶋直敬, 斉藤祥乃, 鳥居さゆ希, 久松隆史, 門田文, 前川聡, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   48 ( 2 )   144 - 144   2013年

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  • 高齢男性における慢性腎臓病と認知機能との関連:滋賀動脈硬化疫学研究

    藤吉朗, 大久保孝義, 三浦克之, 椎野顕彦, 宮川尚子, 高嶋直敬, 齋藤祥乃, 鳥居さゆ希, 門田文, 門脇紗也佳, 久松隆史, 宮澤伊都子, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   48 ( 2 )   147 - 147   2013年

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  • 日本人一般男性集団における脈波伝播速度と頸動脈内膜中膜肥厚および頸動脈プラークとの関連:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    鳥居さゆ希, 藤吉朗, 門田文, 高嶋直敬, 門脇紗也佳, 久松隆史, 斎藤祥乃, 宮川尚子, MARYAM Zaid, 大久保孝義, 三浦克之, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   45th   317 - 317   2013年

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  • 地域住民男性における生涯喫煙量と内臓脂肪との関連:SESSA研究

    藤吉朗, 三浦克之, 三浦克之, 門脇紗也佳, 門田文, 大久保孝義, 大久保孝義, 宮川尚子, 久松隆史, 齋藤祥乃, 鳥居さゆ希, 宮澤伊都子, 三ッ浪健一, 前川聡, 村田喜代史, 上島弘嗣, 上島弘嗣

    肥満研究   19 ( Supplement )   196 - 196   2013年

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  • Lipoprotein Particle Profiles by Nuclear Magnetic Resonance, Standard Lipids and Coronary Artery Calcification in a Japanese General Population: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    第45回日本動脈硬化学会抄録   2013年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 早期再分極(early repolarization)症候群の病態と遺伝基盤,長期予後に関する研究 早期再分極と冠動脈疾患死亡との関連についての研究:NIPPON DATA90による15年追跡結果

    堀江稔, 久松隆史, 山本孝, 大久保孝義, 三浦克之, 藤吉朗, 高嶋直敬, 喜多義邦, 村上義孝, 岡村智教, 上島弘嗣

    早期再分極(early repolarization)症候群の病態と遺伝基盤、長期予後に関する研究 平成24年度 総括・分担研究報告書   11 - 26   2013年

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    記述言語:日本語  

    J-GLOBAL

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 国民健康・栄養調査(2008-2010年)における血圧測定精度の検討:INTERMAP日本研究との比較

    三浦克之, 久松隆史, 久松隆史, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成24年度 総括・分担研究報告書   2013年

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  • ALCOHOL CONSUMPTION AND INFLAMMATION MARKERS: SHIGA EPIDEMIOLOGICAL STUDY OF SUBCLINICAL ATHEROSCLEROSIS (SESSA)

    S. Torii, K. Miura, A. Fujiyoshi, T. Ohkubo, A. Kadota, T. Hisamatsu, Y. Saitoh, S. Kadowaki, S. Suzuki, N. Miyagawa, H. Ueshima

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   36   109A - 109A   2012年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

    Web of Science

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  • Effect modification of dietary n-3 fatty acids on cardiovascular mortality risk by resting heart rate in japanese general population: NIPPON DATA80

    T. Hisamatsu, K. Miura, T. Ohkubo, N. Okuda, Y. Murakami, N. Miyagawa, M. Horie, T. Okamura, A. Okayama, H. Ueshima

    EUROPEAN HEART JOURNAL   33 ( - )   123 - 123   2012年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS  

    Web of Science

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  • 循環器疾患による早世(65歳未満死亡)の要因の検討:NIPPON DATA80

    高嶋直敬, 高嶋直敬, 三浦克之, 大久保孝義, 村上義孝, 喜多義邦, 門田文, 藤吉朗, 宮川尚子, 久松隆史, 鳥居さゆ希, 斎藤祥乃, 早川岳人, 岡村智教, 岡山明, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   47 ( 2 )   113 - 113   2012年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器病予防学会  

    J-GLOBAL

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  • 日本人一般男性における心疾患死亡リスクに対する早期再分極とn-3不飽和脂肪酸摂取量との交互作用の検討:NIPPON DATA80

    久松隆史, 久松隆史, 三浦克之, 大久保孝義, 宮川尚子, 藤吉朗, 高嶋直敬, 門田文, 奥田奈賀子, 村上義孝, 村上義孝, 堀江稔, 岡村智教, 岡山明, 上島弘嗣, 上島弘嗣

    日本心臓病学会誌   7 ( Supplement 1 )   285 - 285   2012年

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    記述言語:日本語   出版者・発行元:(一社)日本心臓病学会  

    J-GLOBAL

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  • 日本人一般男性集団における脈波伝播速度と冠動脈石灰化との関連:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    鳥居さゆ希, 大久保孝義, 藤吉朗, 門田文, 門田文, 高嶋直敬, 高嶋直敬, 門脇紗也佳, 久松隆史, 齋藤祥乃, 宮川尚子, 村上義孝, 三浦克之, 上島弘嗣, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   35th   401 - 401   2012年

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    記述言語:日本語   出版者・発行元:(NPO)日本高血圧学会  

    J-GLOBAL

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  • Effect modification of dietary n-3 fatty acids on cardiovascular mortality risk by resting heart rate general population:NIPPON DATA80

    T Hisamatsu, K Miura, T Ohkubo, N Okuda, Y Murakami, N Miyagawa, M Horie, T Okamura, A Okayama, H Ueshima

    ESC2012   - ( - )   ---   2012年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • Interaction of Dietary n-3 Fatty Acids on Cardiac Risk by J-point elevation in japanese Men: NIPPON DATA.

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Akira Fujiyoshi, Naoyuki Takashima, Aya Kadota, Nagako Okuda, Akira Okayama, Hirotsugu Ueshima

    AHA EPI | NPAM 2012(サンディエゴ)   2012年

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    掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 症例:ブラッドアクセス側腕頭静脈狭窄に対してPTAを施行し,シャント高血圧が改善した維持血液透析患者の1例

    望月裕司, 田中雅博, 久松隆史, 大平直人, 筒井崇

    奈良県医師会透析部会誌   17 ( 1 )   80 - 80   2012年

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    記述言語:日本語   出版者・発行元:奈良県医師会透析部会  

    J-GLOBAL

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  • データブック アテローム血栓症の大規模臨床試験 PART 3 6.包括的管理・治療 REACH 5.アテローム血栓症を有する外来患者における1年追跡による循環器イベント発生率の検討(REACH Registry)

    久松隆史, 三浦克之, 堀江稔

    血栓と循環   19 ( 3 )   2011年

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  • ループス腎炎に対する免疫抑制剤加療中に出現した尿蛋白量の減少にACE阻害薬(イミダプリル)が奏効した一例

    下垣 保恵, 筒井 崇, 大平 直人, 久松 隆史, 田中 雅博, 望月 裕司, 豊田 嘉清, 中井 直治, 竹内 孝男, 郡山 健治, 河野 厚

    臨床リウマチ   22 ( 4 )   389 - 393   2010年12月

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    記述言語:日本語   出版者・発行元:(一社)日本臨床リウマチ学会  

    50歳女性。患者はループス腎炎の寛解期に蛋白尿が出現した。蛋白尿はステロイドにタクロリムスとARB併用することで低下したが、正常範囲には至らず、ARBをACE-Iに変更したところ、正常値範囲に至った。

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J02269&link_issn=&doc_id=20110113250004&doc_link_id=10.14961%2Fcra.22.389&url=https%3A%2F%2Fdoi.org%2F10.14961%2Fcra.22.389&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 今なぜ,トータル血管マネージメントが必要なのか 血管マネージメント 2)日本人の脳卒中,心筋梗塞,腎臓病に対するリスク因子の寄与度の違い:わが国の疫学研究から

    久松隆史, 久松隆史, 大久保孝義, 堀江稔, 三浦克之

    Mebio   27 ( 10 )   2010年

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  • 血液透析患者に発症した深部静脈血栓症に対して下大静脈フィルター留置後血栓溶解療法を施行した1例

    望月裕司, 相原衣江, 田中雅博, 久松隆史, 吉野知秀, 筒井崇

    奈良県医師会透析部会誌   15 ( 1 )   128 - 129   2010年

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    記述言語:日本語   出版者・発行元:奈良県医師会透析部会  

    J-GLOBAL

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  • 血液透析患者に発症した深部静脈血栓症に対して下大静脈フィルター留置後血栓溶解療法を施行した1例

    望月裕司, 相原衣江, 田中雅博, 久松隆史, 吉野知秀, 筒井崇, 近藤雅彦, 栗原陽次郎

    日本透析医学会雑誌   42 ( Supplement 1 )   699 - 699   2009年

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

    J-GLOBAL

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  • 破骨型多核巨細胞の出現を伴った、末梢型肺原発腺癌の1例

    久松 恵理子, 加地 政秀, 早川 美緒, 上地 隆史, 赤松 弘朗, 西島 正剛, 美川 達郎, 大谷 賢一郎, 柳生 恭子, 紙森 隆雄, 藤原 寛, 橘 真由美, 寺村 一裕

    肺癌   48 ( 2 )   145 - 145   2008年4月

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    記述言語:日本語   出版者・発行元:(NPO)日本肺癌学会  

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  • 上腕アプローチよりF-Pバイパスに対してPTAを施行した1例

    上野義記, 道智賢市, 久松隆史, 大林靖典, 北川成子, 小野進

    滋賀医学   30   112 - 112   2008年

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    記述言語:日本語   出版者・発行元:(一社)滋賀県医師会  

    J-GLOBAL

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  • 経皮的血管縫合デバイス(パークローズAT)使用後に急性大腿動脈閉塞症を合併した1症例

    久松隆史, 上野義記, 川口民郎, 大林靖典, 北川成子, 小野進

    Circulation Journal   71 ( Supplement 2 )   923 - 923   2007年

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

    J-GLOBAL

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  • 敗血症性肺塞栓にて発症した心室中隔欠損症に伴う感染性心内膜炎の一例

    吉野 知秀, 久松 隆史, 坪内 直也, 松本 鉄也, 堀江 稔, 浅井 徹, 白石 昭一郎

    Circulation Journal   69 ( Suppl.III )   981 - 981   2005年10月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

    CiNii Article

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  • 冠動脈造影にて有意狭窄を認めなかった労作性狭心症の1症例

    久松 隆史, 中江 一郎, 高島 弘行, 松尾 信郎, 松本 鉄也, 堀江 稔

    Circulation Journal   69 ( Suppl.II )   874 - 874   2005年4月

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    記述言語:日本語   出版者・発行元:(一社)日本循環器学会  

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▼全件表示

講演・口頭発表等

  • Association of Accurately Measured Office, Self-measured Home, and Ambulatory Blood Pressure and Their Variability with Intracranial Arterial Stenosis

    Hisamatsu T, Ohkubo T, Fujiyoshi A, Torii S, Segawa H, Kond K, Kadota A, Takashima N, Shitara S, Arima H, Nakagawa Y, Watanabe Y, Shiino A, Nozaki K, Ueshima H, Miura K

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2021 

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    開催年月日: 2021年5月20日 - 2021年5月21日

    記述言語:英語  

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  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率:益田研究

    久松隆史, 福田茉莉, 谷口かおり, 宮川健, 中畑典子, 神田秀幸

    第79回日本公衆衛生学会総会 

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    開催年月日: 2020年10月20日 - 2020年10月22日

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  • 島根県益田市におけるIoTを活用した血圧管理プロジェクト 招待

    久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    第1回Digital Hypertension Conference  2019年10月25日 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連:滋賀動脈硬化疫学研究

    久松隆史, 大久保孝義, 藤吉朗, 鳥居さゆ希, 瀬川裕佳, 近藤慶子, 門田文, 高島直敬, 設楽智史, 有馬久富, 中川義久, 渡邉嘉之, 椎野顯彦, 野崎和彦, 上島弘嗣, 三浦克之

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    開催年月日: 2021年1月27日 - 2021年1月29日

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  • 海外留学ネットワーキングセミナー 招待

    久松隆史

    第84回日本循環器学会学術集会 

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    開催年月日: 2020年7月27日 - 2020年8月2日

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  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田 茉莉, 神田秀幸

    第30回日本疫学会学術総会 

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    開催年月日: 2020年2月20日 - 2020年2月22日

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討, NIPPON DATA80.

    久松隆史, 三浦克之, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 早川岳人, 神田秀幸, 岡村智教, 岡山明, 上島弘嗣

    第42回日本高血圧学会総会  2019年 

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    開催年月日: 2019年10月25日 - 2019年10月27日

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  • Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA 招待

    Takashi Hisamatsu

    Cardiovascular Epidemiology Seminar Series, Northwestern University  2019年1月25日 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study

    Hisamatsu T, Miura K, Fujiyoshi A, Kunimura A, Shiino A, Nozaki K, Arima H, Ohkubo T, Ueshima H

    第83回日本循環器学会学術集会  2019年 

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  • The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) 招待

    IDACO/IDHOCO/IDCARS Consortium Meeting 2019  2019年 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Objectively measured step counts was independently associated with higher cognition in apparently healthy Japanese men

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • The Association between Coronary Artery Calcium and the Cerebral Small Vessel Disease

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • Association of serum N-3 polyunsaturated fatty acids and high-sensitivity C-reactive protein in Japanese general population from Shiga Epidemiological Study of Subclinical Arteriosclerosis

    第82回日本循環器学会学術集会  2018年 

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population

    AHA EPI Lifestyle 2018 Scientific Sessions  2018年 

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    会議種別:ポスター発表  

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  • Gut microbiota and coronary artery calcification in a general population of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis

    第82回日本循環器学会学術集会  2018年 

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  • A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1

    第82回日本循環器学会学術集会  2018年 

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較、及びその差に影響を及ぼす要因の検討

    第40回日本高血圧学会総会  2017年 

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  • Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men

    第52回日本アルコール・アディクション医学会学術集会  2017年 

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    49回日本動脈硬化学会総会・学術集会  2017年 

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  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    49回日本動脈硬化学会総会・学術集会  2017年 

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連

    第53回日本循環器病予防学会学術集会  2017年 

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討 パイロット研究

    第53回日本循環器病予防学会学術集会  2017年 

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連

    第53回日本循環器病予防学会学術集会  2017年 

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  • NMR lipoprotein particle distributions and coronary artery calcium in US White and Japanese men aged 40-49 years

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • Prevalence of Intracranial Artery Stenosis and the Association with Conventional Risk Factors of Cardiovascular Dieseases in a General Population of Japanese.

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • Lower eGFR and proteinuria were independently associated with lower cognitive abilities in community-dwelling men in Japan

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017年 

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    会議種別:ポスター発表  

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  • Smoking, smoking cessation and measures of subclinical atherosclerosis in multiple vascular meds in Japanese men.

    ESC CONGRESS 2016.  2016年 

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  • 客観的に評価された歩数値とメタボリック症候群との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    第52回日本循環器病予防学会学術集会  2016年 

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  • Blood pressure measurement in the National Survey in Japan and the future plan for non-mercury era

    The 26th Scientific Meeting of the International Society of Hypertension  2016年 

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  • 潜在性動脈硬化の規定要因:ERA JUMP、SESSAより 招待

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    第47回日本動脈硬化学会総会・学術集会  2015年 

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    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

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  • The High Prevalence of Early Repolarization in Genotyped Long QT Syndrome

    Hasegawa K, Watanabe H, Hisamatsu T, Sonoda K, Ohno S, Itoh H, Ashihara T, Makiyama T, Hayashi H, Horie M

    第78回日本循環器学会総会・学術集会 

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    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • Early repolarization in Japanese general population: new findings from the National Surveys of Circulatory Disorders of Japan (NIPPON DATA)

    Hisamatsu T, Miura K, Ohkubo T, Okamura A, Okayama A, Ueshima H

    第78回日本循環器学会総会・学術集会 

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    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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▼全件表示

受賞

  • 岡山県医師会 会長賞

    2023年  

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  • 日本高血圧学会 学術賞

    2023年  

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  • 日本アルコール・アディクション医学会 若手奨励賞

    2022年  

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  • 日本疫学会 奨励賞

    2022年  

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  • 岡山大学SDGs推進表彰 President Award

    2021年  

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  • 岡山公衆衛生学研究会 緒方賞

    2020年  

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  • 日本循環器病予防学会 奨励賞

    2018年  

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    受賞国:日本国

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  • 島根大学医学部 若手研究者優秀論文賞

    2017年  

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    受賞国:日本国

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  • 日本動脈硬化学会 若手研究者奨励賞

    2017年  

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    受賞国:日本国

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  • 日本心臓病学会 上田賞

    2015年  

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    受賞国:日本国

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共同研究・競争的資金等の研究

  • 腸内細菌叢と認知機能・動脈硬化・フレイルに関する東西4コホート統合疫学研究

    研究課題/領域番号:23H03165  2023年04月 - 2027年03月

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    久松 隆史, 矢野 裕一朗, 有馬 久富, 絹田 皆子, 大久保 孝義, 児島 克英, 佐藤 敦, 福田 茉莉, 佐藤 倫広, 神田 秀幸, 三浦 克之

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    配分額:18460000円 ( 直接経費:14200000円 、 間接経費:4260000円 )

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  • 壮年期を対象とした伴走型血圧管理支援事業の役割と評価:社会的処方の観点から

    研究課題/領域番号:22K11085  2022年04月 - 2026年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    福田 茉莉, 神田 秀幸, 久松 隆史, 中畑 典子, 絹田 皆子

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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  • 外国にルーツを持つ子どものヘルスリテラシー向上を目指すシステム構築

    研究課題/領域番号:22K11062  2022年04月 - 2026年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    土江 梨奈, 神田 秀幸, 福田 誠司, 中島 千惠, 柏木 智子, 久松 隆史, 福田 茉莉

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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  • 「予防・健康づくりに関する大規模実証事業 (運動、栄養、女性の健康、がん検診)」食行動の変容に向けた尿検査及び食環境整備に係る実証事業

    2021年10月 - 2023年03月

    厚生労働省 

    久松隆史

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    担当区分:研究分担者 

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  • 高校生eスポーツアスリートにおける心身の健康実態の解明

    研究課題/領域番号:21K10470  2021年04月 - 2024年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    神田 秀幸, 宮崎 亮, 絹田 皆子, 久松 隆史, 津村 秀樹, 福田 茉莉

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    eスポーツは競技を目的にして行うゲームプレイを指し、若者を中心に世界規模で広がりをみせている。さらに、オンライン上で完結するため、COVID-19流行下で、その競技人口は急速に増加している。一方で、ゲーム障害による健康影響は、精神的影響のみならず、手指・腰痛など身体的影響が指摘されている。特に、成長期にある高校生では、体格や視力を含め、多くの精神的、身体的な健康影響が懸念されている。
    本研究は、高校eスポーツ部に所属する部員(高校生eスポーツアスリート)の身体的・精神的な健康実態を、と同じ高校に通う他部員と比較して、彼らの健康状態などを明らかにする。今後拡大していくであろう新たな健康問題に対して、関連要因を明らかにすることは予防医学上、重要な意味をもつ。
    令和3年度は、岡山県内の高校において、高校生eスポーツアスリートと一般高校生に対して、質問票調査および健康診断結果、生理機能検査(身長・体重・体組成等)を行った。
    高校生eスポーツアスリートは、同じ高校に通う一般高校生と比べ、ゲーム利用時間が長く、利用するゲームの種類数は多かった。しかしながら、ゲーム障害のスクリーニング指標であるIGDT-11によるゲーム障害に該当する者は1人しかいなかった。また高校生eスポーツアスリートの体格は、やせもしくは過体重の割合が一般高校生より高く、極端な体格になりがちであることが分かった。これはゲーム利用によって身体活動量が減ることによる体格への影響が生じていることが考えられた。
    当該年度の研究で、高校生eスポーツアスリートの健康課題が徐々に明らかにできた。今後は、新入生を加えた横断的な調査を実施すると同時に、学年進行をふまえた変化に着目した縦断的な調査を行っていく予定である。

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  • 家庭血圧の長期縦断研究からみた血圧変動の共振現象及び無症候性脳血管障害との関連

    研究課題/領域番号:20K10529  2020年04月 - 2023年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    久松 隆史, 神田 秀幸, 三浦 克之

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    担当区分:研究代表者 

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    研究代表者らは、平成29年から島根県益田市の地域住民約1500名(20-74歳)を対象にIoT技術を活用した最長5年間にわたる家庭血圧測定・管理に関するコホート研究(益田研究)を実施中である。本申請研究では、3年超継続して血圧を測定している者を対象として、蓄積された血圧データをもとに血圧変動に関する解析を実施し、頭部MRI検査を追加した。
    血圧変動に関する解析手順書を作成した。記録された血圧データ(毎日、起床後・就寝前・就寝中午前2・3・4時に測定)にもとづき、変動指数として変動係数、最高-最低値差、平均 変動幅、等を用いて、時間的(季節・曜日・時間帯など時間的な偏り)および量的(最大値・変動幅等)な側面から年間・季節・日間・日内の血圧変動を評価した。
    益田地域医療センター医師会病院において頭部MRI検査を実施した。臨床における頭部MRI検査のプロトコールに準じて標準化された調査手順書を作成し、テストラン実施後、プロトコールを確定させた。頭部MRI検査は、3DT1・T2強調画像、T2-STAR、FLAIR、3D-MRAの多彩な撮影方法を用いて実施した。撮影画像をもとに、放射線科医1名が無症候性脳血管障害(ラクナ梗塞・白質病変・微小出血・脳動脈狭窄)の読影を行った。検査結果については、医師が最終判定を行い、コメントと共に対象者に返却した。
    血圧変動解析・頭部MRI検査が完了次第、データクリーニングを行った。血圧変動データ、頭部MRI検査所見、および益田研究データベースを統合したデータベースを完成させた。統合データベースをもとに、年間・季節・日間・日内の血圧変動の実態・関連要因について、横断的な解析を行った。

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  • 血圧変動共振現象の病態解明を目指したWithコロナ時代における遠隔化・省人化・非接触型コホート研究の基盤開発

    2020年 - 2022年

    公益財団法人岡山医学振興会 

    久松隆史

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    担当区分:研究代表者 

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  • IoT技術を活用した長期にわたり評価された家庭血圧管理状況と血圧変動要因に関する探索的観察研究

    2018年

    共同研究(オムロンヘルスケア株式会社) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 一般日本人女性における不整脈の実態解明と時間医学モデルの構築

    研究課題/領域番号:17K15827  2017年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    久松 隆史

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    研究代表者らは、過去10年以上にわたり、草津市の一般男性約1500名を対象に動脈硬化・認知症に関する疫学研究を実施してきた(日米比較研究ERAJUMP・滋賀動脈硬化疫学研究SESSA、代表者 上島弘嗣(滋賀医科大学))。平成27年からは、新たに同地域の一般女性約800名を対象に同様の疫学研究(SESSA Women、代表者 三浦克之(同大学))を実施中である。本申請研究では、SESSA Women研究における平成29‐31年の参加者を研究対象とし、24時間心電図検査(FM-800,フクダ電子)を追加実施した。
    1)調査の実施:約200名の対象者に対して、24時間心電図を実施した。対象者には、事前に研究者から研究内容の説明を行い、研究参加の同意を得た。検査結果については、医師が最終判定を行い、コメントと共に対象者に返却した。
    2)データの整理・統合データベースの作成:昨年度実施分の24時間心電図データについて、漸次データクリーニングを行った。昨年度実施分の24 時間心電図関連データベースとSESSA Women 研究データベースを統合したデータベースを完成させた。
    3)データの解析、報告:統合データベースを用いて、24 時間心電図解析に基づく、不整脈(心房細動・期外収縮、等)の定性的・定量的指標、日内変動と、以下の項目との関連について横断的な解析を行った。
    1.生活習慣、食習慣、病歴・服薬状況、心理社会的指標、歩数値・活動量、2.肥満指標、血圧値、血液尿生化学指標、炎症・心臓バイオマーカー、運動機能・フレイル、3.認知機能、4.無症候性脳動脈硬化(ラクナ梗塞、白質病変、微小出血、脳動脈狭窄、等)、脳萎縮

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  • 地域一般住民における潜在性甲状腺機能障害と動脈硬化・無症候性脳血管障害との関連

    研究課題/領域番号:16K19250  2016年04月 - 2019年03月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    鳥居 さゆ希, 三浦 克之, 上島 弘嗣, 藤吉 朗, 久松 隆史

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    潜在性甲状腺機能障害と動脈硬化指標・無症候性脳血管障害との関連は、地域一般住民集団においては殆ど解明されていない。本研究では、滋賀県草津市の一般住民男性からの無作為抽出集団において甲状腺ホルモンTSH・FT4等を測定し、潜在性甲状腺機能障害の有病率、潜在性甲状腺機能障害と動脈硬化指標・無症候性脳血管障害との関連について横断的に検討することを目的とした。潜在性甲状腺機能低下および潜在性甲状腺機能亢進の有病率はそれぞれ9.5%、1.6%であった。潜在性甲状腺機能低下および亢進群どちらも、甲状腺機能正常群と比較して、動脈硬化指標・無症候性脳血管障害が有所見となるリスクと有意な関連を認めなかった。

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  • 大腿部CTによる筋肉内異所性脂肪および筋肉量、運動機能と潜在性動脈硬化との関連

    研究課題/領域番号:16K09055  2016年04月 - 2019年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    門脇 紗也佳, 藤吉 朗, 三浦 克之, 東 宏一郎, 上島 弘嗣, 久松 隆史, 鳥居 さゆ希

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    配分額:4810000円 ( 直接経費:3700000円 、 間接経費:1110000円 )

    本研究報告は、動脈硬化性疾患に関する大規模疫学調査の関連課題であり、2期計画であった調査の第1期分の報告である。フレイル(加齢に伴う種々機能低下や生理的予備能力の低下でストレスへの脆弱性が増加した状態)および異所性脂肪が動脈硬化進展と関連することが明らかにされてきた。そこで、フレイルに関する運動機能検査・問診、大腿筋群異所性脂肪の検討のためCT撮影を追加実施した。
    当初の予定通り、前半の調査(女性276名(年齢75±6歳))が終了した。フレイル群は4.0%、前フレイル状態は55.5%、筋肉間脂肪は大腿筋組織の内15%であった

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  • Japanese Paradoxに着目した心血管病の病態理解と新リスク要因の解明

    2016年 - 2019年

    科学研究費補助金(海外特別研究員) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    2016年 - 2018年

    民間学術研究振興費補助金(上原記念生命科学財団) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 一般日本人女性における潜在性動脈硬化と脳萎縮の実態解明

    研究課題/領域番号:15H02528  2015年04月 - 2018年03月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    三浦 克之, 藤吉 朗, 村田 喜代史, 有馬 久富, ABBOTT ROBERT, 椎野 顯彦, 門田 文, 上島 弘嗣, 高嶋 直敬, 野崎 和彦, 久松 隆史, 堀江 稔, 遠山 育夫, 前川 聡, 関川 暁, 岡村 智教, 大久保 孝義, 田原 康玄, 大野 聖子, 門脇 紗也佳, 宮川 尚子

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    配分額:46410000円 ( 直接経費:35700000円 、 間接経費:10710000円 )

    本研究は、高齢化が進行している日本人一般女性集団を対象とし、潜在性動脈硬化、脳萎縮、認知機能障害の実態と関連要因を明らかとし、その予防法を解明することを目的とする。当初より基盤A研究2期分で目標対象者数800名に対して調査を実施する予定であり、平成27-29年度は第1期にあたる。第1期では、草津市住民基本台帳より60-85歳の女性を無作為抽出し、同意を得た266名に対して、胸腹部CT、頭部MRI、頚部超音波、認知機能検査、身体機能評価、血圧、心電図、血液・尿検査、など多岐にわたる調査を実施した。平成30-33年度も、第2期として、さらに約500名に対して調査を実施する予定である。

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  • 日本人一般集団におけるCOPDの有病率及び潜在性動脈硬化指標との関連に関する検討

    研究課題/領域番号:15K09171  2015年04月 - 2018年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    中野 恭幸, 小川 恵美子, 上島 弘嗣, 久松 隆史

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    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    慢性閉塞性肺疾患(COPD)は近年その患者数が増加し、わが国において重要な疾患のひとつとなっている。そこで、滋賀県草津市在住の40歳以上の一般男性住民から無作為抽出した約500名を対象として、呼吸機能検査や脳MRI検査を行った。その結果、約15%がCOPDであると考えられた。また、非喫煙者においては、呼吸機能が低下すると、動脈硬化の指標である脳MRI検査における白質病変やラクナ梗塞が増加する傾向があることが明らかとなった。

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  • 一般住民において腸内細菌叢が潜在性動脈硬化の進展におよぼす影響

    研究課題/領域番号:15H04773  2015年04月 - 2018年03月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    有馬 久富, 上島 弘嗣, 三浦 克之, 安藤 朗, ABBOTT ROBERT, 藤吉 朗, 門田 文, 高嶋 直敬, 近藤 慶子, 門脇 紗也佳, 久松 隆史, 大野 聖子, 宮川 尚子, 門脇 崇, 岡見 雪子

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    配分額:16250000円 ( 直接経費:12500000円 、 間接経費:3750000円 )

    本研究では、滋賀県草津市の一般住民男性を対象とした前向きコホート研究において、669名の対象者の便検体から腸内細菌を同定した。胸部CT画像をもちいて標準的な方法でAgaston Scoreを算出し、10点以上を冠動脈石灰化と定義した。腸内細菌と冠動脈石灰化との関連を検討したところ、Lactobacillusは、冠動脈石灰化の有病リスク低下と関連していた(腸内細菌割合1標準偏差(9%)上昇あたりの多変量調整オッズ比0.84、95%信頼区間0.70-1.00)。Lactobacillusは、動脈硬化に予防的に働く可能性が示唆された。

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  • 筋由来の新規生理活性物質イリシンが肥満・糖尿病・動脈硬化に及ぼす影響の検討

    研究課題/領域番号:15K19224  2015年04月 - 2017年03月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    久松 隆史

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    筋由来生理活性物質(マイオカイン)の一種であるイリシンについて、肥満・糖尿病・脂質などの代謝指標および動脈硬化指標との関連を明らかにすることを目的とした。心血管病の既往のない健常一般集団(40-79歳)において、血清イリシンは、肥満・脂質指標と負の関連を認め、肥満・糖尿病・脂質指標を含む交絡因子を調整後も冠動脈石灰化進展と負の関連を認めた。イリシンが心血管病や代謝性疾患を予防するかどうかを含め今後更なる研究の実施が望まれる。

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  • 筋強直性ジストロフィー患者の心電図の経時的分析による致死性不整脈の因子分析とデバイス適応の検討

    2015年 - 2019年

    厚生労働科学研究費補助金 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 筋・肝・腹部脂肪が糖・インスリン代謝に及ぼす影響:地域住民7年追跡コホート研究

    研究課題/領域番号:26293140  2014年04月 - 2018年03月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    藤吉 朗, 東 宏一郎, 門脇 紗也佳, 上島 弘嗣, 三浦 克之, 久松 隆史, 村田 喜代史, 前川 聡

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    配分額:17160000円 ( 直接経費:13200000円 、 間接経費:3960000円 )

    当初の計画通り予定していた全画像のべ約2400名分の読影を完了し、データの整備を行った。糖・インスリン代謝関連指標も測定完了した。これらのデータをもとに予備解析を行い、以下の知見を得た。1)本邦40歳以上の一般地域住民男性において、年齢に伴うBMI(体格指数)の低下は筋肉量の減少と相関していた一方、脂肪筋の増加と関連していた。2)高齢と体重は筋肉とその脂肪組成を予測する重要な因子であることが示された。3)またVAT(腹部内臓脂肪)は年齢との相関を認めなかったが血糖・脂質代謝および炎症との相関が他の指標に比べて強かった。

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  • 認知機能低下・海馬萎縮に関連する心臓調律異常の疫学的検証

    2014年 - 2015年

    民間学術研究振興費補助金(花王健康科学研究会) 

    久松隆史

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    担当区分:研究代表者  資金種別:競争的資金

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  • 日本人一般集団における心拍変動スペクトル指標と無症候性脳血管障害との関連の探求

    研究課題/領域番号:25893097  2013年08月 - 2015年03月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    久松 隆史

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    配分額:2730000円 ( 直接経費:2100000円 、 間接経費:630000円 )

    自律神経機能を反映する心拍変動(HRV)指標と脳卒中との関連は一般人口集団においてほとんど解明されていない。本研究では、循環器疾患既往のない日本人一般地域住民からの無作為抽出集団において、24時間心電図から定量化したHRV指標と頭部MRI検査を用いて評価した無症候性脳血管障害との関連を横断的に検討することを目的とした。夜間帯(2時-2時15分)および24時間の時間領域解析指標SDNN、周波数領域解析指標LF、HF、LF/HF比は、ラクナ梗塞、微小出血、白質病変、脳動脈狭窄など無症候性脳血管障害と有意な関連を認めなかった。日本人一般住民において、HRV指標は無症候性脳血管障害と関連がなかった。

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  • 動脈硬化の進展にかかわる新しいバイオマーカーの探索

    研究課題/領域番号:25253046  2013年04月 - 2017年03月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    上島 弘嗣, 藤吉 朗, 宮川 尚子, 喜多 義邦, 大久保 孝義, 門田 文, 久松 隆史, 高嶋 直敬, 三浦 克之, 村上 義孝

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    配分額:46020000円 ( 直接経費:35400000円 、 間接経費:10620000円 )

    (1)縦断解析:インスリン抵抗性と冠動脈硬化進展、歩数とメタボリックシンドローム発症との関連、(2)国際共同研究:米国住民コホートMESAとの冠動脈硬化日米比較、ピッツバーグ大学等との共同研究にてオメガ‐3脂肪酸と冠動脈石灰化発症との関連等、(3)遺伝子、メタボローム、新興バイオマーカー:アルデヒドデヒドロゲナーゼ遺伝子多型とLDL-コレステロール、リポプロティン関連ホスフォリパーゼA2とその遺伝子多型と潜在性動脈硬化との関連等を明らかにした。尿中メタボローム・酸化変性LDLも測定済みであり引き続き有用なバイオマーカーの探求を続ける。

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  • 地域住民における無症候性脳血管障害・海馬萎縮の関連要因:コホート東西比較

    研究課題/領域番号:23249036  2011年04月 - 2015年03月

    日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

    三浦 克之, 上島 弘嗣, 今井 潤, 村田 喜代史, 野崎 和彦, 椎野 顯彦, 大久保 孝義, 寶澤 篤, 藤吉 朗, 久松 隆史, 堀江 稔, 遠山 育夫, 戸恒 和人, 荒井 啓行, 村上 義孝, 門田 文, 菊谷 昌浩, 長澤 晋哉, 浅山 敬, 冨田 尚希, 高嶋 直敬, 廣瀬 卓男, 関川 暁, 近藤 健男, 三木 哲郎

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    配分額:47190000円 ( 直接経費:36300000円 、 間接経費:10890000円 )

    本研究では、脳卒中死亡率高地域(東北)・低地域(関西)に位置する二つの一般住民コホートに頭部MRI撮影を導入し、無症候性脳血管障害の地域差に関わる要因を検討することを目的とした。同一対象者への頭部MRI撮影による両施設間における一致率の検討では、κ係数はラクナ梗塞・微小出血0.60前後、白質病変0.46であった。60-80歳代の10歳毎に東西比較を行ったところ、ラクナ梗塞、微小出血の有所見率は関西よりも東北の方が高く、血圧値・降圧剤服用率共に東北の方が高かったことが有所見率の差に寄与している可能性が考えられた。一方、白質病変の有所見率は東北よりも関西の方が高く、未検討の要因の関与も示唆された。

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その他研究活動

  • 日本疫学会 上級疫学専門家

    2023年04月
    -
    現在

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  • 日本公衆衛生学会 公衆衛生専門家

    2021年04月
    -
    現在

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  • 社会医学系専門医協会 社会医学系指導医・専門医

    2017年03月
    -
    現在

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  • 日本内科学会 総合内科専門医

    2015年12月
    -
    現在

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  • 日本循環器学会 循環器専門医

    2010年04月
    -
    現在

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  • 医師免許

    2003年05月
    -
    現在

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担当授業科目

  • 予防医学 (2023年度) 特別  - その他

  • 公衆衛生学 (2023年度) 特別  - その他

  • 公衆衛生学/疫学・衛生学実習 (2023年度) 特別  - その他

  • 公衆衛生学実習 (2023年度) 特別  - その他

  • 公衆衛生学概論 (2023年度) 特別  - その他

  • 公衆衛生学演習 (2023年度) 特別  - その他

  • 公衆衛生学I(演習・実習) (2023年度) 特別  - その他

  • 公衆衛生学I(講義・演習) (2023年度) 特別  - その他

  • 公衆衛生学II(演習・実習) (2023年度) 特別  - その他

  • 公衆衛生学II(講義・演習) (2023年度) 特別  - その他

  • 医学AI応用特論2 (2023年度) 特別  - その他

  • 研究方法論応用 (2023年度) 特別  - その他

  • 社会医学入門 (2023年度) 第1学期  - 月1~2

  • 社会医歯科学 (2023年度) 集中  - その他

  • 予防医学 (2022年度) 特別  - その他

  • 公衆衛生学 (2022年度) 特別  - その他

  • 公衆衛生学実習 (2022年度) 特別  - その他

  • 公衆衛生学概論 (2022年度) 特別  - その他

  • 公衆衛生学I(演習・実習) (2022年度) 特別  - その他

  • 公衆衛生学I(講義・演習) (2022年度) 特別  - その他

  • 公衆衛生学II(演習・実習) (2022年度) 特別  - その他

  • 公衆衛生学II(講義・演習) (2022年度) 特別  - その他

  • 研究方法論応用 (2022年度) 特別  - その他

  • 社会医学入門 (2022年度) 第1学期  - 月1~2

  • 社会医歯科学 (2022年度) 集中  - その他

  • 公衆衛生学 (2021年度) 特別  - その他

  • 公衆衛生学実習 (2021年度) 特別  - その他

  • 公衆衛生学I(演習・実習) (2021年度) 特別  - その他

  • 公衆衛生学I(講義・演習) (2021年度) 特別  - その他

  • 公衆衛生学II(演習・実習) (2021年度) 特別  - その他

  • 公衆衛生学II(講義・演習) (2021年度) 特別  - その他

  • 研究方法論応用 (2021年度) 特別  - その他

  • 公衆衛生学 (2020年度) 特別  - その他

  • 公衆衛生学実習 (2020年度) 特別  - その他

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社会貢献活動

  • 益田市スマート・ヘルスケア推進事業からみえたもの:尿ナトカリ比をチェック、自分でできる高血圧対策!

    役割:講師

    令和5年度島根県益田市 健康ますだ市21活動報告会  2024年3月17日

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  • 健康長寿を目指した益田市での取り組み -生活習慣病の予防-

    役割:講師

    島根県益田市  健康ますだ市21フェスティバル  2022年10月23日

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    種別:講演会

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  • いきいきライフのすすめ “フレイル予防”をテーマに フレイルの基礎知識

    役割:講師

    岡山県栄養改善協議会  2022年6月16日

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    種別:講演会

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  • 心不全講習会「心不全を識る、診る、予防する」

    役割:講師

    日本循環器病予防学会 特定非営利活動法人 日本高血圧学会 ノバルティス ファーマ 医学教育助成  2022年6月11日

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    種別:資格認定講習

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  • 血圧・脂質異常症・糖尿病の基本的検査の意義と結果の見方

    役割:講師

    日本循環器病予防学会  保健指導レベルアップセミナー  2021年1月23日

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    種別:講演会

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  • IoT技術を活用した家庭血圧管理と脳卒中予防に向けた取り組み

    役割:講師

    島根県益田市  2020年1月24日

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  • 生活習慣と高血圧症

    役割:講師

    益田地域医療センター医師会病院  2019年12月6日

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    種別:会誌・広報誌

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  • 高血圧治療ガイドライン2019の概要と高血圧予防、高血圧管理の重要性

    役割:講師

    島根県  島根県脳卒中対策及び糖尿病対策研修会  2019年11月5日

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    種別:講演会

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  • 脳卒中や心筋梗塞にならないための生活のコツ

    役割:講師

    2016年12月3日

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    種別:講演会

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  • 尿クレアチニン・アルブミン比, 家庭血圧, 尿ナトカリ比

    役割:取材協力, 助言・指導

    益田ヘルスケア推進協会  益田ヘルスケア通信  2021年5月

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    種別:会誌・広報誌

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  • 高血圧と新型コロナウィルス感染症

    役割:編集, 助言・指導

    益田ヘルスケア推進協会  益田ヘルスケア通信  2020年10月

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    種別:会誌・広報誌

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  • IoT技術を活用した家庭血圧管理と脳卒中予防に向けた取り組み

    役割:講師

    島根県益田市  2019年9月20日

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    種別:講演会

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  • タバコは全身の血管を老化させる

    役割:寄稿

    ヘルスアップ21  2017年11月

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    種別:新聞・雑誌

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  • 40代から増える脳卒中

    役割:取材協力

    タウン情報Lazuda  2017年2月

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    種別:新聞・雑誌

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メディア報道

  • 高血圧とは?益田市の現状と肥満との関連 会誌・広報誌

    益田市  広報ますだ11月号  2022年11月

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  • 「測るだけヘルスチェック」で高血圧を予防しよう! 会誌・広報誌

    益田市  広報ますだ3月号  2022年3月

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  • 家庭血圧と尿ナトカリ比の意義 会誌・広報誌

    益田ヘルスケア推進協会  益田ヘルスケア通信No. 6  2021年5月

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    執筆者:本人 

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  • 世界一受けたい授業 岡山県共生高校eスポーツ部 テレビ・ラジオ番組

    日本テレビ  世界一受けたい授業  2020年11月7日

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  • 高血圧と新型コロナウィルス感染症 会誌・広報誌

    益田ヘルスケア推進協会  益田ヘルスケア通信No. 4  2020年11月

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    執筆者:本人 

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  • タバコは全身の血管を老化させる 会誌・広報誌

    ヘルスアップ21  2017年11月

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  • 喫煙者は全身の動脈硬化リスクが上昇 会誌・広報誌

    ヘルスアップ21  2017年5月

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    執筆者:本人 

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  • 今月の健康マメ知識:40代から増える脳卒中 会誌・広報誌

    タウン情報Lazuda  2017年2月

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