Updated on 2022/10/01

写真a

 
HISAMATSU Takashi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
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Degree

  • 博士(医学) ( 滋賀医科大学 )

Research Interests

  • 公衆衛生学

  • 循環器病学

  • メタボローム

  • メンデルランダム化

  • 予防医学

  • 腸内細菌

  • 疫学

  • 高血圧

  • ビックデータ

  • AI

  • IoT

  • COVID-19

Research Areas

  • Life Science / Cardiology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Medical management and medical sociology

Education

  • Shiga University of Medical Science   大学院医学系研究科  

    2009.4 - 2013.3

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    Country: Japan

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  • Shiga University of Medical Science   医学部   医学科

    1997.4 - 2003.3

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    Country: Japan

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Research History

  • Okayama University   Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences   Associate Professor

    2020.1

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  • 日本学術振興会海外特別研究員 Northwestern University Feinberg School of Medicine(留学)

    2017.2 - 2019.1

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  • Shiga University of Medical Science   社会医学講座公衆衛生学部門

    2016.4

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  • Shimane University   Faculty of Medicine   Associate Professor

    2016.4 - 2019.12

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  • Shiga University of Medical Science   アジア疫学研究センター (現NCD疫学研究センター)

    2013.4 - 2016.3

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  • Northwestern University Feinberg School of Medicine   非常勤講師

    2019.2

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  • Shiga University of Medical Science   循環器内科

    2011.4 - 2013.3

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  • 大阪回生病院   医員

    2008.4 - 2011.3

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  • 日本赤十字社長浜赤十字病院   医員

    2005.6 - 2008.3

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  • Shiga University of Medical Science   University Hospital

    2003.5 - 2005.5

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Professional Memberships

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Committee Memberships

  •   日本疫学会 疫学研究推進WG委員/選挙規定検討委員会委員  

    2022.4   

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  • 倉敷市保健所   医療コーディネーター(新型コロナウィルス対策班)  

    2021.9   

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  • Frontiers in Epidemiology   編集委員  

    2021.9   

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    Committee type:Academic society

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  • 医療系大学間共用試験実施評価機構医学系CBT実施小委員会   ブラッシュアップ専門部会委員  

    2021.6   

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  • 岡山県新型コロナウィルスクラスター対策班   専門家  

    2020.9   

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  • 健康市民おかやま21推進会議   評価部会委員  

    2020.7   

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  • 日本動脈硬化学会   評議員  

    2019.7   

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    Committee type:Academic society

    日本動脈硬化学会

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  • 一般社団法人益田ヘルスケア推進協会   理事  

    2019.7   

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    Committee type:Academic society

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  • Korean Circulation Journal   編集委員  

    2017.11   

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    Committee type:Academic society

    The Korean Society of Cardiology (Korea)

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  • 日本循環器病予防学会   評議員  

    2017.6   

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    日本循環器病予防学会

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  • 島根県出雲市脳卒中予防対策検討会議   委員  

    2019.4   

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  • 島根県感染症発生動向調査委員会   委員  

    2019.4   

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  • 島根県出雲圏域健康長寿しまね推進会議   委員  

    2019.4   

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  • 島根県保健環境科学研究所・原子力環境センター調査研究課題検討委員会   委員  

    2019.4   

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Papers

  • Associations of indoor and outdoor temperatures and their difference with home blood pressure: The Masuda Study. Reviewed

    Kinuta M, Hisamatsu T, Fukuda M, Taniguchi K, Komukai S, Nakahata N, Kanda H

    Hypertension Research   2022.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

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  • Association of ambulatory blood pressure with aortic valve and coronary artery calcification. Reviewed International journal

    Yuichi Sawayama, Takashi Hisamatsu, Aya Kadota, Sayuki Torii, Keiko Kondo, Akira Fujiyoshi, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of hypertension   40 ( 7 )   1344 - 1351   2022.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. METHODS: In this population-based, cross-sectional study, we assessed office BP, mean ambulatory BP (24-h, awake, and asleep), and variability of ambulatory BP, as determined by the coefficient of variation (awake and asleep). AVC and CAC were quantified using an Agatston score (>0) based on computed tomography scanning. We calculated relative risks (RRs) and 95% confidence intervals (CIs) with a 1-standard deviation increment in each BP index for the presence of AVC and CAC using a multivariate-adjusted Poisson regression with robust error variance. RESULTS: Of 483 participants (mean age: 66.8 years), 154 (31.9%) and 310 (64.2%) had AVC and CAC, respectively. The presence of AVC was associated with office systolic BP (SBP; RR, 1.15; 95% CI, 1.03-1.28), awake diastolic BP (DBP) variability (RR, 1.12; 95% CI, 1.01-1.25), and asleep SBP variability (RR, 1.14; 95% CI, 1.03-1.27). The presence of CAC was associated with office SBP (RR, 1.08; 95% CI, 1.01-1.15), mean 24-h SBP (RR, 1.10; 95% CI, 1.04-1.16), mean awake SBP (RR, 1.11; 95% CI, 1.04-1.17), mean asleep SBP (RR, 1.07; 95% CI, 1.01-1.13), and asleep SBP variability (RR, 1.07; 95% CI, 1.01-1.13). CONCLUSION: These findings highlight the association of ambulatory BP indices with both AVC and CAC, but with different effects on their presences.

    DOI: 10.1097/HJH.0000000000003147

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  • Alcohol consumption and subclinical and clinical coronary heart disease: A Mendelian randomization analysis Reviewed

    Hisamatsu T, Miura K, Tabara Y, Sawayama Y, Kadowaki T, Kadota A, Torii S, Kondo K, Yano Y, Fujiyoshi A, Yamamoto T, Nakagawa Y, Horie M, Kimura T, Okamura T, Ueshima H, for the SESSA, ACCESS Research Groups

    European Journal of Preventive Cardiology   2022.7

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    Authorship:Lead author, Corresponding author  

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  • Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men. Reviewed International journal

    Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

    The American journal of cardiology   169   51 - 56   2022.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79 years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, lipid-lowering therapy were included in multivariable negative binomial regression to assess independent correlates for the number of VPCs per hour. We observed at least 1 VPC in 1 hour in 429 men (83%). In multivariable negative binomial regression adjusted for all covariates simultaneously, age (risk ratio [95% confidence interval] 1.91 [1.56 to 2.33] per 1-SD increment), height (1.17 [1.04 to 1.49] per 1-SD increment), resting heart rate(1.34 [1.02 to 1.77] per 1-SD increment), diabetes mellitus (2.36 [1.17 to 4.76] ), hypertension (1.90 [1.03 to 3.50]), physical activity (0.67 [0.47 to 0.97] ), current smoking (4.23 [1.86 to 9.60] ), past smoking (2.08 [1.03 to 4.19] ), current light alcohol consumption (0.16 [0.04 to 0.64] ), and lipid-lowering therapy (0.47 [0.23 to 0.96] ) were independently associated with VPCs frequency. In conclusion, VPCs frequency was independently associated with age, height, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy.

    DOI: 10.1016/j.amjcard.2021.12.046

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  • Home blood pressure variability and target organ damage. Invited Reviewed International journal

    Takashi Hisamatsu, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension   45 ( 3 )   543 - 545   2022.3

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1038/s41440-021-00844-6

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  • The association between problematic internet use and neck pain among Japanese schoolteachers. Reviewed International journal

    Rina Tanabe, Takashi Hisamatsu, Mari Fukuda, Hideki Tsumura, Rina Tsuchie, Masako Suzuki, Nagisa Sugaya, Koshi Nakamura, Kenzo Takahashi, Hideyuki Kanda

    Journal of occupational health   63 ( 1 )   e12298   2021.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: Problematic internet use (PIU) has been suggested in relation to psychological symptoms among schoolteachers, but the relationship with physical symptoms remains unclear. We examined whether PIU or longer Internet usage time is associated with neck pain in schoolteachers. METHODS: We conducted a cross-sectional study among 2582 teachers aged 20 years or older (35.6% women) in Shimane and Tottori, Japan in 2018. Neck pain was defined as ≥5 points on the Neck Disability Index. The Compulsive Internet Use Scale (CIUS) was used to assess PIU. Internet usage time on weekdays and weekends was divided into five groups: 0, 1-29, 30-59, 60-119, and ≥120 min/day. Logistic regression analysis was conducted to examine the association of the CIUS score and Internet usage time on weekdays or weekends with neck pain, adjusting for sex, age, position at school, insomnia, and psychological distress. RESULTS: We observed 800 (31.0%) teachers with neck pain. The median (interquartile range) of their CIUS scores was 7 (2, 14). A higher CIUS score was independently associated with a higher prevalence of neck pain (odds ratio of 4th vs. 1st quartiles, 1.41; 95% confidence interval, 1.06-1.87; trend P = .006). Compared with non-Internet users, Internet users on weekdays had almost double the odds of neck pain although the difference did not reach the customary level for designating statistical significance. CONCLUSIONS: In conclusion, teachers with higher scores in CIUS were associated with a higher prevalence of neck pain in Japan, suggesting adults with PIU being at risk of physical disorders.

    DOI: 10.1002/1348-9585.12298

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  • Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Reviewed International journal

    Takashi Hisamatsu, Donald M Lloyd-Jones, Laura A Colangelo, Kiang Liu

    Journal of hypertension   39 ( 8 )   1586 - 1593   2021.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Data are sparse regarding the impact of sodium and potassium intakes on serial blood pressure (BP) levels during long-term follow-up. METHODS: Among 1007 Coronary Artery Risk Development in Young Adults participants (mean age, 30.2 years; 53% blacks; 57% women) who had at least two 24-h urine samples collected at year 5 (Y5) examination, we assessed associations of urinary sodium and potassium excretions with BP trends and incident hypertension in the subsequent 25 years. Participants were classified by sex-specific medians for averaged 24-h urinary excretions: lower sodium and higher potassium (Na-Lo-K-Hi); higher sodium and lower potassium (Na-Hi-K-Lo); and others. RESULTS: In the adjusted generalized estimating equation model, SBP and DBP greatly increased in the Na-Hi-K-Lo group (n = 185) compared with the Na-Lo-K-Hi group (n = 185), with statistically significant BP differences at Y20, Y25, and Y30 (mean SBP, 3.93, 4.94, and 4.88 mmHg, respectively; and mean DBP, 4.70, 4.95, and 4.59 mmHg, respectively). During 25-year follow-up, among 926 participants without prevalent hypertension by Y5, 381 (41.1%) developed hypertension. In the adjusted Cox proportional hazards model, the Na-Hi-K-Lo group had hazard ratio (95% confidence interval), 1.45 (1.00-2.10) for incident hypertension compared with the Na-Lo-K-Hi group. The association with incident hypertension was predominant in blacks and white women (race--sex interaction, P = 0.03). Sodium-to-potassium ratio and sodium excretion were positively, whereas potassium excretion was inversely, associated with incident hypertension (all P trend <0.05). CONCLUSION: Our findings highlight the importance of dietary sodium reduction and higher potassium intake for hypertension prevention among young adults.

    DOI: 10.1097/HJH.0000000000002802

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  • Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis. Reviewed International journal

    Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of hypertension   Publish Ahead of Print ( 10 )   2030 - 2039   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.

    DOI: 10.1097/HJH.0000000000002900

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  • Relationship between insomnia with alcohol drinking before sleep (Ne-Zake) or in the morning (Mukae-Zake) among Japanese farmers. Reviewed International journal

    Rie Sato, Takashi Hisamatsu, Hideki Tsumura, Mari Fukuda, Kaori Taniguchi, Haruo Takeshita, Hideyuki Kanda

    Alcohol (Fayetteville, N.Y.)   93   57 - 62   2021.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Ne-Zake is the drinking of alcohol before sleeping for helping to fall asleep and sleep well, and Mukae-Zake is the drinking of alcohol in the morning for "calming down" or "curing hangovers". OBJECTIVE: We sought to examine the relationship of insomnia with Ne-Zake and Mukae-Zake among healthy middle-aged Japanese farmers. METHODS: In a cross-sectional study of 746 participants (mean age, 59.5 years; women, 25.9%), Ne-Zake and Mukae-Zake were defined based on a self-administered questionnaire. Insomnia was defined as the Athens Insomnia Scale Japanese version ≥6 or usage of sleeping pills in the previous year. Logistic regression was used to calculate odds ratio (OR) of insomnia related to Ne-Zake and Mukae-Zake adjusting for sex, age, presence of sleep-related disorders, frequency of alcohol consumption, and quantity of alcohol consumed per one occasion. RESULTS: We observed insomnia, Ne-Zake, and Mukae-Zake in 174 (23.3%), 140 (18.8%), and 37 (5.0%) participants, respectively. After adjustment for demographic and confounding factors, participants with Ne-Zake had a significantly higher prevalence of insomnia (OR 2.00 [95% confidence interval, 1.27-3.16]), compared to those without Ne-Zake. Mukae-Zake was also independently associated with a higher prevalence of insomnia among men (OR 3.26 [1.55-6.87]). Participants with both Ne-Zake and Mukae-Zake had a highly significant association with insomnia (OR 4.77 [2.01-11.3]) than those with neither Ne-Zake nor Mukae-Zake. Additionally, for insomnia, the association of Mukae-Zake was more pronounced than that of Ne-Zake (OR 4.09, 95% CI 1.14-14.7, p = 0.031; and OR 1.81, 95% CI 1.08-3.06, p = 0.026, respectively). CONCLUSION: Ne-Zake and Mukae-Zake were associated with insomnia independent of the quantity and frequency of alcohol consumption among Japanese farmers. This finding can be used for stratifying individuals with insomnia not only to improve sleep hygiene but also to prevent alcohol dependence by informing the general population that alcohol has a negative effect on sleep, contrary to popular beliefs.

    DOI: 10.1016/j.alcohol.2020.11.005

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  • Epidemiology and control of hypertension in Japan: a comparison with Western countries Invited Reviewed

    Takashi Hisamatsu, Katsuyuki Miura

    Journal of Human Hypertension   2021.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41371-021-00534-3

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    Other Link: http://www.nature.com/articles/s41371-021-00534-3

  • Effect of Coronavirus Disease 2019 Pandemic on Physical Activity in a Rural Area of Japan: The Masuda Study. Reviewed

    Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Minako Kinuta, Noriko Nakahata, Hideyuki Kanda

    Journal of epidemiology   31 ( 3 )   237 - 238   2021.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Epidemiological Association  

    DOI: 10.2188/jea.JE20200598

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  • Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines Invited Reviewed

    Takashi Hisamatsu, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura

    Hypertension Research   43 ( 12 )   1344 - 1351   2020.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41440-020-0508-z

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    Other Link: http://www.nature.com/articles/s41440-020-0508-z

  • Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years. Reviewed International journal

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    Journal of hypertension   38 ( 11 )   2230 - 2236   2020.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.

    DOI: 10.1097/HJH.0000000000002533

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  • Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. Reviewed International journal

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Sayuki Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Stroke   50 ( 10 )   2967 - 2969   2019.10

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    Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors. Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to <50%), or severe-ICAS (≥50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group. Results- The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors. Conclusions- In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.

    DOI: 10.1161/STROKEAHA.119.025964

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  • 過度の上室期外収縮と無症候性脳血管疾患との関連性 集団ベースの研究(Association between Excessive Supraventricular Ectopy and Subclinical Cerebrovascular Disease: A Population-Based Study) Reviewed

    Hisamatsu Takashi, Miura Katsuyuki, Fujiyoshi Akira, Kunimura Ayako, Shiino Akihiko, Nozaki Kazuhiko, Arima Hisatomi, Ohkubo Takayoshi, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   83回 ( 9 )   PE50 - 4   2019.3

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    Authorship:Lead author, Corresponding author   Language:English   Publisher:(一社)日本循環器学会  

    DOI: 10.1111/ene.13970

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ene.13970

  • Coronary Artery Calcium Progression Among the US and Japanese Men Reviewed

    Takashi Hisamatsu, Kiang Liu, Cheeling Chan, Amy E. Krefman, Akira Fujiyoshi, Matthew J. Budoff, Katsuyuki Miura, Donald M. Lloyd-Jones, Hirotsugu Ueshima

    Circulation: Cardiovascular Imaging   12 ( 2 )   2019.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1161/circimaging.118.008104

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  • Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea Invited Reviewed

    Takashi Hisamatsu

    Korean Circulation Journal   49 ( 11 )   1049 - 1049   2019.1

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Korean Society of Cardiology  

    DOI: 10.4070/kcj.2019.0197

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    Other Link: https://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.2019.0197

  • Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Hisatomi Arima, Akira Fujiyoshi, Atsushi Satoh, Aya Kadota, Maryam Zaid, Naoyuki Takashima, Seiko Ohno, Minoru Horie, Hirotsugu Ueshima

    Journal of Hypertension   36 ( 11 )   2193 - 2203   2018.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    DOI: 10.1097/hjh.0000000000001810

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  • Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    International Journal of Cardiology   267   177 - 182   2018.9

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    Background: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. Methods and results: We performed a prospective, population-based study of Japanese men aged 40–79 years without known coronary heart disease. We measured baseline serum irisin levels using an enzyme-linked immunosorbent assay and quantified coronary artery calcification (CAC) from serial computed tomography scans. Of 1038 participants (mean age, 63.9 years) at baseline, 670 (64.6%) had prevalent CAC. Of 810 participants at follow-up (median, 5.1 years), 407 (50.3%) experienced CAC progression. In Poisson regression with robust error variance adjusted for age and behavioral factors, serum irisin levels were inversely associated with CAC prevalence (relative risk [RR] of 4th versus 1st quartiles [95% confidence interval], 0.88 [0.78–0.99]
    trend P = 0.016) and CAC progression (RR, 0.76 [0.63–0.91]
    trend P = 0.002). After further adjustment for cardiometabolic risk factors, the inverse association with CAC prevalence disappeared (RR, 0.95 [0.84–1.08]
    trend P = 0.319), but that with CAC progression persisted (RR, 0.77 [0.64–0.93]
    trend P = 0.003). These associations were consistent when we applied ordinal logistic regression and across subgroups by cardiometabolic risk factor status. Conclusions: Higher serum irisin levels were associated with less burden of coronary atherosclerosis. This association would be mediated through and beyond traditional cardiometabolic pathways.

    DOI: 10.1016/j.ijcard.2018.05.075

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  • Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

    Atherosclerosis   273   145 - 152   2018.6

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    Background and aims: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). Methods: We conducted a prospective study in a population-based sample of Japanese men aged 40–79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method. Results: Of 938 participants at baseline (mean age, 63.7 ± 9.9 years), AVC prevalence was observed in 173 (18.4%). Of 596 participants without baseline AVC at follow-up (median duration, 5.1 years), AVC incidence was observed in 138 (23.2%). After adjustment for demographics, behaviors and cardiovascular risk factors, relative risks (95% confidence intervals) in the highest versus lowest categories of serum magnesium, phosphorus, and calcium were 0.62 (0.44–0.86), 1.45 (1.02–2.04), and 1.43 (0.95–2.15), respectively, for AVC prevalence and 0.62 (0.42–0.92), 1.93 (1.28–2.91), and 1.09 (0.77–1.55), respectively, for AVC incidence. Their linear trends of serum magnesium and phosphorus were also all statistically significant. Of 131 participants with baseline AVC, there was no association of any serum micronutrients with AVC progression. Conclusions: Serum magnesium was inversely associated, while serum phosphorus was positively associated with AVC prevalence and incidence, suggesting that these serum micronutrients may be potential candidates for risk prediction or prevention of CAVD, and warranting further studies.

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  • Increased Aortic Calcification Is Associated With Arterial Stiffness Progression in Multiethnic Middle-Aged Men Reviewed

    Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Hypertension   69 ( 1 )   102 - 108   2017.1

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    Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association of aortic calcification burden with progression of arterial stiffness in population-based samples of healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort). Men (n=635) aged 40 to 49 years (207 white American, 45 black American, 142 Japanese American, and 241 Japanese in Japan) were examined at baseline and 4 to 7 years later. Aortic calcification was evaluated from level of aortic arch to iliac bifurcation. Arterial stiffness progression was measured as annual change in brachial-ankle pulse wave velocity. Multivariable-adjusted general linear models were applied to investigate associations of longitudinal change in aortic calcification with arterial stiffness progression in participants overall, as well as in subgroups without or with prevalent aortic calcification at baseline. Annual change in aortic calcification was positively and significantly associated with arterial stiffness progression. In participants with annual changes in aortic calcium score of 0, 1 to 10, 11 to 100, and &gt;100, the adjusted means (SD) for the annual change in brachial-ankle pulse wave velocity were 3.8 (2.2), 7.2 (2.2), 12.2 (1.8), and 15.6 (2.6) cm/s, respectively (P for trend &lt;0.01) adjusted for baseline aortic calcification, arterial stiffness, and standard cardiovascular risk factors. Arterial stiffness was associated with the incidence of aortic calcification over the follow-up period among participants without aortic calcification (n=297) and with an increase in aortic calcification among participants with prevalent aortic calcification at baseline (n=388). Our findings suggest aortic calcification may be causally linked to arterial stiffness.

    DOI: 10.1161/HYPERTENSIONAHA.116.08459

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  • Step counts measured with a pedometer and risk of incident metabolic syndrome: a 5-year follow-up of population-based cohort (Shiga Epidemiological Study of Subclinical Atherosclerosis, SESSA) Reviewed

    久松隆史, 久松隆史, 三浦克之, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 柳田昌彦, 前川聡, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017

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  • Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Sayuki Torii, Sentaro Suzuki, Naoko Miyagawa, Atsushi Sato, Masahiro Yamazoe, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Yamamoto, Kiyoshi Murata, Robert D. Abbott, Akira Sekikawa, Minoru Horie, Hirotsugu Ueshima, Yasutaka Nakano, Emiko Ogawa, Hiroshi Maegawa, Itsuko Miyazawa, Kenichi Mitsunami, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Yasuyuki Nakamura, Tomonori Okamura, Emma J.M. Barinas‐Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Yoshitaka Murakami, Naoyuki Takashima, Takashi Kadowaki, Seiko Ohno, Keiko Kondo, Yoshino Saito, Maryam Zaid, Takahiro Ito, Takeshi Shibukawa, Masaki Sumi

    Journal of the American Heart Association   5 ( 9 )   e003738   2016.8

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    DOI: 10.1161/jaha.116.003738

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  • Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components Reviewed

    Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima

    Arteriosclerosis, Thrombosis, and Vascular Biology   36 ( 8 )   1703 - 1708   2016.8

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    DOI: 10.1161/atvbaha.116.307612

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  • Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population Reviewed

    Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

    Atherosclerosis   236 ( 2 )   237 - 243   2014.10

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    DOI: 10.1016/j.atherosclerosis.2014.07.019

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  • High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    JOURNAL OF CARDIOLOGY   64 ( 3-4 )   218 - 224   2014.9

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    Background: Increased resting heart rate (RHR) independently predicts cardiovascular mortality. Meanwhile, long-chain n-3 fatty acids (LCn3FAs) have a cardioprotective effect. Our aim was to evaluate whether higher LCn3FAs intake attenuates the elevated risk of cardiovascular mortality associated with increased RHR.
    Methods: We conducted a population-based 24-year prospective cohort study of Japanese, whose LCn3FAs intake is relatively high. Study participants included 8807 individuals aged 30-95 years from randomly selected areas across Japan without cardiovascular diseases and anti-hypertensive drugs at baseline. The primary endpoint was cardiovascular mortality, and the secondary endpoints were cardiac and stroke mortality during 24 years of follow-up. Individual dietary LCn3FAs intake was estimated from household-based 3-day weighed food records. RHR was obtained from 3 consecutive R-wave intervals on 12-lead electrocardiography. Cox models were used to estimate the multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) adjusting for possible confounders.
    Results: During the follow-up period, 617 cardiovascular deaths were observed. The median daily intake of LCn3FAs was 0.37% kcal (0.86 g/day). The interaction between dietary LCn3FAs intake and RHR in the risk of cardiovascular mortality was statistically significant (p = 0.033). The risk of cardiovascular mortality was significantly higher in the low-intake group (&lt;0.37% kcal) with an RHR &gt;85 beats/min (bpm) [hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.15-2.43], but not in the high-intake group (&gt;= 0.37% kcal) with an RHR &gt;85 bpm (HR, 0.92; 95% CI, 0.61-1.38), compared with those in the high-intake group with an RHR &lt;70 bpm. Similar results were observed with stroke mortality, but not with cardiac mortality.
    Conclusions: The risk of cardiovascular mortality associated with increased RHR is elevated in participants with low dietary LCn3FAs intake, but not in participants with high dietary LCn3FAs intake in a representative Japanese general population. These results suggest that high dietary LCn3FAs intake may prevent cardiovascular mortality associated with increased RHR. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jjcc.2014.01.005

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  • Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men Reviewed

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

    Heart   99 ( 14 )   1024 - 1029   2013.7

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    Objective Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) &gt;= 0.1 mV on electrocardiography.
    Design A prospective population-based cohort study.
    Setting The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan.
    Participants A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan.
    Main outcome measures Cardiac death (200 men) during the 24-year follow-up.
    Results Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35% kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (&lt;0.35% kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p&lt;0.001), but not in the high intake group (&gt;= 0.35% kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006).
    Conclusions The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.

    DOI: 10.1136/heartjnl-2012-303496

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  • Association between J-Point elevation and death from coronary artery disease Reviewed

    Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, for the NIPPON DATA, Research Group

    Circ J.   77 ( 5 )   1260 - 1266   2013

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  • Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men. Reviewed

    Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   2022.9

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    AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on atherosclerotic plaque formation in the general population remains unknown. We assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population. METHODS: Community-dwelling Japanese men (n=622) aged 46-82 years without a history of cardiovascular disease and lipid-lowering medications were included. Serum PCSK9 concentration and CAC score were measured using the Agatston method, and the multivariable analysis was used to assess their association. CAC was defined as an Agatston score of >10. We conducted further analysis stratified by age (<60, 60-69, and ≥ 70 years). RESULTS: The average age, LDL-C, and median serum PCSK9 concentration were 68 years, 122 mg/dL, and 240 ng/mL, respectively. After multivariable adjustment for traditional cardiovascular risk factors, no significant association was observed between serum PCSK9 concentration and CAC prevalence (adjusted relative risk [aRR] 1.05, 95% confidence interval [CI] 0.97-1.13). With age stratification, serum PCSK9 concentration was significantly associated with CAC prevalence in men aged <60 years (aRR 1.38, 95% CI 1.01-1.88) but not in men aged 60-69 years (aRR 0.96, 95% CI 0.85-1.10) or ≥ 70 years (aRR 1.08, 95% CI 0.99-1.19). CONCLUSIONS: A higher serum PCSK9 concentration was associated with a higher CAC prevalence in men aged <60 years, which was independent of traditional cardiovascular risk factors.

    DOI: 10.5551/jat.63549

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  • Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90). Reviewed International journal

    Kota Kubo, Tomonori Okamura, Daisuke Sugiyama, Takashi Hisamatsu, Aya Hirata, Aya Kadota, Keiko Kondo, Takumi Hirata, Aya Higashiyama, Takehito Hayakawa, Yoshihiro Miyamoto, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

    The American journal of cardiology   2022.9

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    The relation between chronic kidney disease (CKD) and cardiovascular disease (CVD) in the general population is well elucidated. In patients with CKD, anemia is associated with adverse outcomes. However, the effects of CKD and anemia on CVD in the general population remains poorly explored, especially in Asian populations. This study aimed to investigate the effect of CKD and/or anemia on CVD mortality in a long-term cohort study involving Japanese community dwellers. We assessed 7,339 participants (aged ≥30 years) with no CVD history. These participants were divided into 4 categories according to their CKD (estimated glomerular filtration rate <60 or urine protein >1+ by dipstick qualitative test) and/or anemia (hemoglobin: <13 g/100 ml [men], <12 g/100 ml [women]) statuses. For each category, we calculated the hazard ratios (HRs) of CVD mortality by using the Cox proportional hazards model after adjusting for age, body mass index, hypertension, diabetes, dyslipidemia, smoking, and alcohol drinking. Within 25 years of follow-up, 637 participants died because of CVD. The HRs of CVD in patients with CKD only, anemia only, and both were 1.27, 1.59, and 2.60 (95% confidence intervals [CI] 1.06 to 1.53, 1.34 to 1.90, and 1.80 to 3.76) in men and 1.42, 1.08, and 2.00 (95% CI 1.19 to 1.69, 0.99 to 1.18, and 1.54 to 2.60) in women, respectively. In conclusion, CKD with anemia is associated with an increased risk for CVD mortality in a general population in Japan.

    DOI: 10.1016/j.amjcard.2022.08.027

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  • Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men. Reviewed International journal

    Keiko Kondo, Hisatomi Arima, Akira Fujiyoshi, Akira Sekikawa, Aya Kadota, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Katsutaro Morino, Naoko Miyagawa, Hiroyoshi Segawa, Yoshiyuki Watanabe, Hiroshi Maegawa, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Cerebrovascular diseases (Basel, Switzerland)   1 - 7   2022.4

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    BACKGROUND: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. METHODS: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. RESULTS: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. CONCLUSIONS: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.

    DOI: 10.1159/000524243

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  • Premature Atrial Contractions and Their Determinants in a General Population of Japanese Men. Reviewed

    Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

    Circulation journal : official journal of the Japanese Circulation Society   2022.2

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    BACKGROUND: Premature atrial contractions (PACs) are predictors of atrial fibrillation, stroke, and cardiovascular mortality. The present study aimed to assess relevant factors for PACs among a general population of Japanese men.Methods and Results:This study conducted a population-based, cross-sectional study among 517 men, aged 40-79 years, with neither apparent myocardial infarction nor atrial fibrillation. 24-h Holter electrocardiography to assess PAC frequency was used. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, mean heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy were included in multivariable negative binomial regression analyses to assess correlation for the number of PACs per hour. Almost all participants (99%) had at least 1 PAC in 1 h (median number 2.84 PACs per h). In multivariable negative binomial regression after adjusting for all covariates simultaneously, age (relative risk [95% confidence interval], 1.30 [1.08-1.57] per 1-standard deviation [SD] increment), height (1.19 [1.02-1.39] per 1-SD increment), triglycerides (0.79 [0.65-0.97] per 1-SD increment), mean heart rate (0.69 [0.59-0.80] per 1-SD increment), physical activity (0.63 [0.43-0.93]), current smoking (1.69 [1.06-2.69]), current moderate (1.97 [1.23-3.16]) and heavy (1.84 [1.12-3.01]) alcohol consumption were independently associated with PAC frequency. CONCLUSIONS: PAC frequency was independently associated with age, height, smoking, alcohol consumption, heart rate, physical activity, and triglycerides.

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  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90

    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ

    Journal of Epidemiology   32 ( Suppl.1 )   124 - 124   2022.1

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  • Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification Reviewed

    Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shinichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa, Ebtehal Salman, Itsuko Miyazawa, Takashi Yamamoto, Yoshihisa Nakagawa, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   2021.10

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    AIMS: The roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression. METHODS: A total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of >10 Agatston units (AU) among men with 0<CAC<100 AU at baseline, that of >10% among those with CAC ≥ 100 AU, and any progression for those with CAC=0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model. RESULTS: The mean follow-up period was 4.9 years. CAC progression was detected in 45.8% of participants. Positive associations between CAC progression and albuminuria (>30mg/g) (RR: 1.29; 1.09 to 1.53; p=0.004) and low eGFRcys (<60ml/min/1.73m2) (RR: 1.27; 1.05 to 1.53; p=0.012) remained significant after adjustments for age, the follow-up time, and computerized tomography type. Following further adjustments for hypertension, diabetes mellitus, dyslipidemia, C-reactive protein, and lifestyle factors, CAC progression was associated with albuminuria (RR: 1.20; 1.01 to 1.43; p=0.04) and low eGFRcys (RR: 1.19; 0.99 to 1.43; p=0.066), but not with eGFRcre. CONCLUSION: CAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.

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  • 地域住民男性における大豆イソフラボン代謝産物エクオールと冠動脈石灰化との横断的関連 SESSA研究

    藤吉 朗, 三浦 克之, 門田 文, 有馬 久富, 関川 暁, 近藤 慶子, 門脇 紗也佳, 岡見 雪子, 鈴木 春満, 久松 隆史, 中川 義久, 東山 綾, 岡村 智教, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   53回   248 - 248   2021.10

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  • Prologue: Special Spotlight Issue on Japan Invited Reviewed International journal

    Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario

    Journal of Human Hypertension   2021.8

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    DOI: 10.1038/s41371-021-00589-2

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  • Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men(和訳中) Reviewed

    Vu Thien, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Zaid Maryam, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Nakagawa Yoshihisa, Suzuki Tomoaki, Asai Tohru, Miura Katsuyuki, Ueshima Hirotsugu

    Circulation Journal   85 ( 7 )   1076 - 1082   2021.6

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    BACKGROUND: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. CONCLUSIONS: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.

    DOI: 10.1253/circj.CJ-20-1090

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  • Apolipoprotein A2 Isoforms: New Insight into the Risk of Myocardial Infarction Invited Reviewed

    Takashi Hisamatsu

    Journal of Atherosclerosis and Thrombosis   28 ( 5 )   469 - 470   2021.5

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    DOI: 10.5551/jat.ed150

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  • Corrigendum to "A challenge for mutation specific risk stratification in long QT syndrome type 1" [J. Cardiol. 72(1) (2018) 56-65]. International journal

    Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno

    Journal of cardiology   77 ( 3 )   322 - 326   2021.3

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  • A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium. Reviewed

    Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   29 ( 2 )   282 - 295   2021.2

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    AIMS: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. METHODS: Japanese men aged 40-79y (n=869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCAmean), internal carotid artery (ICAmean) and bifurcation (Bifmean). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. RESULTS: All cIMT measures had positive associations with CAC (p<0.001): [OR, 95% Confidence Interval]: ICAmean [1.23, 1.07-1.42], CCAmean [1.27, 1.08-1.49], Bifmean [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile (p<0.05), while CCAmean had some of the weakest associations among age quartiles. CONCLUSIONS: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCAmean, was no longer associated with coronary calcium after age-adjustment and stratification.

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  • Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study. Reviewed International journal

    Mohammad Moniruzzaman, Aya Kadota, Akihiko Shiino, Akira Fujiyoshi, Takahiro Ito, Ali Haidar Syaifullah, Naoko Miyagawa, Keiko Kondo, Takashi Hisamatsu, Hiroyoshi Segawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

    Journal of physical activity & health   18 ( 2 )   157 - 164   2021.1

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    BACKGROUND: To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. METHODS: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). RESULTS: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). CONCLUSIONS: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.

    DOI: 10.1123/jpah.2019-0659

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  • Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men. Reviewed International journal

    Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 1 )   80 - 87   2021.1

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    Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40-79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

    DOI: 10.1038/s41440-020-00533-w

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  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS). Reviewed International journal

    Kei Asayama, Yasuharu Tabara, Emi Oishi, Satoko Sakata, Takashi Hisamatsu, Kayo Godai, Mai Kabayama, Yukako Tatsumi, Jun Hata, Masahiro Kikuya, Kei Kamide, Katsuyuki Miura, Toshiharu Ninomiya, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension   43 ( 12 )   1403 - 1412   2020.12

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    Despite the clinical usefulness of self-measured home blood pressure (BP), reports on the characteristics of home BP have not been sufficient and have varied due to the measurement conditions in each study. We constructed a database on self-measured home BP, which included five Japanese general populations as subdivided aggregate data that were clustered and meta-analyzed according to sex, age category, and antihypertensive drug treatment at baseline (treated and untreated). The self-measured home BPs were collected after a few minutes of rest in a sitting position: (1) the morning home BP was measured within 1 h of waking, after urination, before breakfast, and before taking antihypertensive medication (if any); and (2) the evening home BP was measured just before going to bed. The pulse rate was simultaneously measured. Eligible data from 2000 onward were obtained. The morning BP was significantly higher in treated participants than in untreated people of the same age category, and the BP difference was more marked in women. Among untreated residents, home systolic/diastolic BPs measured in the morning were higher than those measured in the evening; the differences were 5.7/5.0 mmHg in women (ranges across the cohorts, 5.3-6.8/4.7-5.4 mmHg) and 7.3/7.7 mmHg in men (ranges, 6.4-8.5/7.0-8.7 mmHg). In contrast, the home pulse rate in women and men was 2.4 (range, 1.5-3.7) and 5.6 (range, 4.6-6.6) beats per minute, respectively, higher in the evening than in the morning. We demonstrated the current status of home BP and home pulse rate in relation to sex, age, and antihypertensive treatment status in the Japanese general population. The approach by which fine-clustered aggregate statistics were collected and integrated could address practical issues raised in epidemiological research settings.

    DOI: 10.1038/s41440-020-0530-1

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  • Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men. Reviewed International journal

    Mohammad Moniruzzaman, Aya Kadota, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Naoko Miyagawa, Akira Fujiyoshi, Takashi Hisamatsu, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

    Stroke   51 ( 12 )   3584 - 3591   2020.12

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    BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.

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  • The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. Reviewed International journal

    Aya Hirata, Akemi Kakino, Tomonori Okamura, Yoko Usami, Yoshiko Fujita, Aya Kadota, Akira Fujiyoshi, Takashi Hisamatsu, Keiko Kondo, Hiroyoshi Segawa, Tatsuya Sawamura, Katsuyuki Miura, Hirotsugu Ueshima

    Atherosclerosis   313   20 - 25   2020.11

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    BACKGROUND AND AIMS: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). METHODS: We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). RESULTS: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively. CONCLUSIONS: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.

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  • Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey Reviewed

    Toshiki Sanoh, Eri Eguchi, Tetsuya Ohira, Fumikazu Hayashi, Masaharu Maeda, Seiji Yasumura, Yuriko Suzuki, Hirooki Yabe, Atsushi Takahashi, Kanae Takase, Mayumi Harigane, Takashi Hisamatsu, Keiki Ogino, Hideyuki Kanda, Kenji Kamiya

    International Journal of Environmental Research and Public Health   17 ( 21 )   7832 - 7832   2020.10

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    Evidence regarding the effect of psychological factors and evacuation on cardiovascular disease occurrence after large-scale disasters is limited. This prospective study followed up a total of 37,810 Japanese men and women aged 30–89 years from the Fukushima Prefecture with no history of stroke or heart disease at baseline (2012), until 2017. This period included 3000 cardiovascular events recorded through questionnaires and death certificates. The participants’ psychological distress, trauma reaction, and evacuation status were defined, and divided into four groups based on combinations of psychological factors and evacuation status. We calculated the hazard ratios and 95% confidence intervals for only psychological, only evacuation, or both of them compared with neither using Cox proportional hazard models. Psychological factors along with evacuation resulted in approximately 5% to 25% higher magnitude of stroke and heart disease risk than psychological factors only among men. Compared to neither, the multivariable hazard ratios of those with both psychological distress and evacuation were 1.75 for stroke and 1.49 for heart disease, and those of both trauma reaction and evacuation were 2.01 and 1.57, respectively, among men. Evacuation combined with psychological factors increased the risk of stroke and heart disease risks especially in men after the Great East Japan Earthquake.

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  • The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study. Reviewed

    Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   27 ( 9 )   995 - 1009   2020.9

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    AIM: Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs in a healthy Japanese male population. METHODS: In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. CAC was scored using the Agatston method. The following SCVDs were assessed using magnetic resonance imaging: intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds. The participants were categorized according to CAC scores as follows: no CAC (0), mild CAC (1-100), and moderate-to-severe CAC (>100). The adjusted odds ratios of prevalent SCVDs were computed in reference to the no-CAC group using logistic regression. RESULTS: The mean (standard deviation) age of the participants was 68 (8.4) years. Participants in the moderate-to-severe CAC category showed significantly higher odds of prevalent lacunar infarction, DSWMH, and ICAS in age-adjusted and risk-factor-adjusted models. Microbleeds and PVH, in contrast, did not show any significant associations. The trends for CAC with lacunar infarction, DSWMH, and ICAS were also significant (all P-values for trend ≤ 0.02). CONCLUSIONS: Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels.

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  • Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1. Reviewed International journal

    Hideki Itoh, Takashi Hisamatsu, Takuhisa Tamura, Kazuhiko Segawa, Toshiaki Takahashi, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Shugo Suwazono, Shingo Sasaki, Ken Okumura, Minoru Horie, Masanori P Takahashi, Tsuyoshi Matumura

    Journal of the American Heart Association   9 ( 17 )   e015709   2020.9

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    Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow-up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow-up period of 87 months (Q1-Q3, 37-138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22-15.50) were associated with sudden death. In contrast, PQ interval ≥240 ms, QRS duration ≥120 ms, nutrition, or respiratory failure were not associated with the incidence of sudden death. The multivariable analysis revealed that a PQ interval ≥240 ms (HR, 2.79; 95% CI, 1.9-7.19, P<0.05) or QRS duration ≥120 ms (HR, 9.41; 95% CI, 2.62-33.77, P < 0.01) were independent factors associated with a higher occurrence of cardiac events than those observed with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. Conclusions Cardiac conduction disorders are independent markers associated with cardiac events. Further investigation on the prediction of occurrence of sudden death is warranted.

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  • Smoking habits and progression of coronary and aortic artery calcification: A 5-year follow-up of community-dwelling Japanese men Reviewed

    Tai Pham, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Ayako Kunimura, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    International Journal of Cardiology   314   89 - 94   2020.9

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  • 日本人一般男性を対象とした脳MRIを用いた無症候性脳血管疾患と四つの血圧指標との関連性評価(Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men) Reviewed

    Salman Ebtehal, Kadota Aya, Hisamatsu Takashi, Segawa Hiroyoshi, Torii Sayuki, Fujiyoshi Akira, Kondo Keiko, Arima Hisatomi, Shiino Akihiko, Miura Katsuyuki, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   84回 ( 2 )   OE118 - 3   2020.7

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    AIM: The relationship of blood pressure (BP) indexes (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], mean arterial pressure [MAP]) to subclinical cerebrovascular diseases (SCVDs) remains unclear. This study aimed to elucidate the relationship of four BP indexes measured at two visits on SCVDs assessed by magnetic resonance imaging (MRI) in general Japanese men. METHODS: In general Japanese men aged 40-79 years (N=616), office BP indexes were measured at two visits (Visits 1 [2006-2008] and 2 [2010-2014]). MRI images obtained on the third visit (2012-2015) were examined for prevalent SCVDs: lacunar infarction, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), microbleeds, and intracranial artery stenosis (ICAS). Using a multivariable logistic regression analysis, we computed and estimated the odds ratio of each prevalent SCVD for one standard deviation higher BP indexes. The same analyses were performed using home BP. RESULTS: All four office BP indexes at both visits associated with lacunar infarction. Visit 1 and 2 DBP and Visit 1 MAP associated with PVH and DSWMH, and Visit 1 SBP associated with DSWMH. All Visit 2 BP indexes appear to show stronger association with microbleeds than Visit 1 indexes, and Visit 1 and 2 SBP, PP, and MAP showed similar associations with ICAS. Additional analyses using home BP indexes revealed similar relationships; however, the significance of some relationships decreased. CONCLUSION: In general Japanese men, BP indexes were associated with most of SCVDs, and BP indexes measured at different periods associated with different SCVDs assessed by MRI.

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  • Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. Reviewed

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Sayuki Torii, Naoyuki Takashima, Ikuo Tooyama, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 6 )   244 - 252   2020.6

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    BACKGROUND: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. METHODS: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score, with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. RESULTS: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend = 0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend = 0.015) in mutual-adjustment model. CONCLUSIONS: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.

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  • Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study. Reviewed

    Ziyi Liu, Maryam Zaid, Takashi Hisamatsu, Sachiko Tanaka, Akira Fujiyoshi, Naoko Miyagawa, Takahiro Ito, Aya Kadota, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   30 ( 3 )   121 - 127   2020.3

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    BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.

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  • Physical activity levels in American and Japanese men from the ERA-JUMP Study and associations with metabolic syndrome. Reviewed International journal

    Naoko Sagawa, Bonny Rockette-Wagner, Koichiro Azuma, Hirotsugu Ueshima, Takashi Hisamatsu, Tomoko Takamiya, Aiman El-Saed, Katsuyuki Miura, Andrea Kriska, Akira Sekikawa

    Journal of sport and health science   9 ( 2 )   170 - 178   2020.3

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    Background: Metabolic syndrome (MetS) is a global health problem. Physical activity (PA) is a known modifiable risk factor for MetS and individual MetS components. However, the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors. To examine these differences, multi-country studies with standardized outcome measurement methods across cohorts are needed. Methods: Cross-sectional PA levels (total and domain specific) in healthy middle-aged (44-56 years) men in the Risk Factor Assessment among Japanese and U.S. Men in the Post-World War II Birth Cohort (ERA-JUMP) Study (n = 730; American: n = 417; Japanese: n = 313; from population-representative samples in Pittsburgh, Pennsylvania, USA, and Kusatsu, Shiga, Japan) were compared. The relationships between PA levels and MetS (overall and specific components) in/across the American and Japanese sub-cohorts (adjusting for age, smoking, and alcohol consumption) were also assessed using the same instruments (pedometer and validated questionnaire) to measure PA in both cohorts. Results: A total of 510 individuals provided complete data on PA (American: n = 265; Japanese: n = 245). The American cohort had significantly lower mean ± SD steps/day (7878 ± 3399 steps/day) vs. the Japanese cohort (9055 ± 3797 steps/day) (p < 0.001) but had significantly higher self-reported moderate-vigorous leisure PA (American: 15.9 (7.4-30.3) metabolic task equivalent hours per week (MET-h/week) vs. Japanese: 4.0 (0-11.3) MET-h/week, p < 0.0001). In both sub-cohorts, each 1000 steps/day increase was associated with lower odds of having MetS (American: OR = 0.90, 95%CI: 0.83-0.98; Japanese: OR = 0.87, 95%CI: 0.79-0.95) and the individual MetS component of high waist circumference (American: OR = 0.86, 95%CI: 0.79-0.94; Japanese: OR = 0.87, 95%CI: 0.80-0.95). In the American cohort only, higher self-reported leisure PA (Met-h/week) was associated with lower odds of MetS and high waist circumference (OR = 0.98, 95%CI: 0.97-0.99 for MetS and waist circumference, respectively). Conclusion: Higher total step counts/day had an important protective effect on MetS prevalence in both the Japanese and American cohorts, despite differences in PA levels and other MetS risk factors. The effect of steps/day (across all intensity levels) was much greater than domain-specific moderate-vigorous PA captured by questionnaire, suggesting the need for measurement tools that can best capture total movement when examining the effects of PA on MetS development.

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  • Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis) Reviewed

    Keiko Fuse, Aya Kadota, Keiko Kondo, Katsutaro Morino, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Itsuko Miyazawa, Satoshi Ugi, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

    Diabetes Research and Clinical Practice   160   108002 - 108002   2020.2

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  • Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men. Reviewed

    Yuyan Liu, Akira Fujiyoshi, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Itsuko Miyazawa, Keiko Kondo, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   26 ( 12 )   1102 - 1114   2019.12

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    AIM: Computed tomography (CT) can directly provide information on body compositions and distributions, compared to anthropometric indices. It has been shown that various obesity indices are associated with carotid intima-media thickness (IMT). However, whether CT-based obesity indices are stronger than anthropometric indices in association with atherosclerosis remains to be determined in a general population. METHODS: We cross-sectionally assessed carotid IMT using ultrasound in 944 community-dwelling Japanese men free of stroke and myocardial infarction. CT image at the L4-L5 level was obtained to compute areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Anthropometric measures assessed included body mass index (BMI), waist circumference, and waist-to-hip ratio. Using multivariable linear regression, slopes of IMT per 20th to 80th percentile of each index were compared. We also compared the slope of index with simultaneous adjustment for BMI in the same model. RESULTS: Areas of VAT and SAT were positively associated with IMT, but not stronger than those of anthropometric indices in point estimates. Among all obesity indices, BMI was strongest in association with IMT after adjusting for age and lifestyle factors or further adjusting for metabolic factors. In simultaneous adjustment models, BMI, but not CT-based indices, remained significant and showed the strongest association. CONCLUSIONS: In community-dwelling Japanese men, anthropometric obesity indices, BMI in particular, were more strongly associated with carotid atherosclerosis than CT-based obesity indices. The association of general obesity with carotid atherosclerosis was strong and adding CT-based obesity measure did not considerably influence in the association.

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  • Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men Reviewed International journal

    Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa

    Open Heart   6 ( 2 )   e001119 - e001119   2019.12

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    <sec><title>Objective</title>This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese).

    </sec><sec><title>Methods</title>In a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD).

    </sec><sec><title>Results</title>The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=−2% to 3%).

    </sec><sec><title>Conclusions</title>Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.

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  • The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. Reviewed International journal

    Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of hypertension   37 ( 8 )   1676 - 1681   2019.8

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    OBJECTIVE: We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men. METHODS: We analyzed the data of 919 Japanese male participants who were randomly selected from general population (mean age 64.5 years). OBP was measured twice consecutively by a trained nurse using electrical device after 5 min of complete rest alone in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during 7 consecutive days. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score at least 10. We calculated odds ratios for the presence of CAC per one SD higher OBP and HBP adjusted for age and other cardiovascular risk factors. RESULTS: The mean systolic OBP (SD) and HBP (SD) were 136.8 (19.0) and 137.2 (18.5) mmHg, respectively, without statistical difference between the two (P = 0.595). OBP and HBP were highly correlated (r = 0.74 P < 0.001). CAC was found in 454 (49.4%) participants. Multivariable-adjusted odds ratios [95% confidence interval (CI)] for the presence of CAC were comparable between OBP (1.32, 95% CI: 1.12-1.56) and HBP (1.35, 95% CI: 1.14-1.60) (P heterogeneity = 0.813). CONCLUSION: The strength of association of accurately measured OBP with CAC was comparable with that of HBP among randomly selected male general population aged 40-79 years.

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Reviewed

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, for the NIPPON DATA, Research Group

    Journal of atherosclerosis and thrombosis   26 ( 8 )   746 - 746   2019.7

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    DOI: 10.5551/jat.ER17244

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  • Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). Reviewed

    Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of epidemiology   29 ( 6 )   205 - 212   2019.6

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    BACKGROUND: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. METHODS: From 2006-2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1-160.9, 161-321.9, 322-482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. RESULTS: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. CONCLUSIONS: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

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  • Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men Reviewed

    Cecilia Kimani, Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Maryam Zaid, Sayaka Kadowaki, Takashi Hisamatsu, Hisatomi Arima, Minoru Horie, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   26 ( 5 )   452 - 464   2019.5

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  • Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men Reviewed

    Akira Sekikawa, Hemant Mahajan, Sayaka Kadowaki, Takashi Hisamatsu, Naoko Miyagawa, Akira Fujiyoshi, Aya Kadota, Hiroshi Maegawa, Kiyoshi Murata, Katsuyuki Miura, Daniel Edmundowicz, Hirotsugu Ueshima

    European Journal of Clinical Nutrition   73 ( 5 )   783 - 792   2019.5

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    DOI: 10.1038/s41430-018-0242-7

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  • Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Reviewed

    Ruriko Seto-Yukimura, Emiko Ogawa, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Kazuhiko Nozaki, Akira Fujiyoshi, Katsuyuki Miura, Yasutaka Nakano, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   25 ( 10 )   1009 - 1021   2018.10

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  • Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men Reviewed

    Itsuko Miyazawa, Takayoshi Ohkubo, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Matthew Budoff, Kiyoshi Murata, Katsuyuki Miura, Hiroshi Maegawa, Hirotsugu Ueshima

    Circulation Journal   82 ( 10 )   2542 - 2548   2018.9

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    BACKGROUND: Pericardial fat volume (PFV), defined as the volume of ectopic fat in and around the heart, is associated with the atherosclerotic process in coronary arteries. The magnitude of change in PFV over time and the factors affecting this change in a general population, however, have not been investigated. Methods and Results: Cardiac computed tomography (CT) was carried out at baseline and at follow-up in 623 Japanese men aged 40-79 years without a history of cardiovascular disease who were selected randomly in Kusatsu (Shiga, Japan). PFV was measured on cardiac CT in a qualified laboratory. Age, heart rate, triglycerides, and obesity measurements (weight, body mass index, and waist circumference) were significantly and positively associated with PFV at baseline. Over an average interval of 4.7 years, median PFV increased significantly from 64.1 cm3 (IQR, 47.2-90.0 cm3) to 73.6 cm3 (IQR, 53.3-98.1 cm3; P<0.001). Current smoking and heart rate were significantly and independently associated with changes in PFV (B=3.336, P<0.001 and B=6.409, P=0.003, respectively). CONCLUSIONS: PFV increased significantly over time in a population-based observational study of Japanese men. PFV change was significantly and independently associated with smoking status and heart rate, suggesting that quitting smoking might help reduce PFV, which could be expected to decrease the risk of coronary artery disease.

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  • Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea Reviewed

    Abhishek Vishnu, Jina Choo, Aya Kadota, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Dorothy Leann Long, Takashi Hisamatsu, Vasudha Ahuja, Yasuyuki Nakamura, Rhobert W. Evans, Katsuyuki Miura, Kamal H. Masaki, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    International Journal of Cardiology   266   245 - 249   2018.9

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    Background: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. Methods: We conducted a population-based study among apparently healthy middle-aged men aged 40–49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. Results: Whites (22.8%) had more than four-fold higher prevalence (p &lt
    0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors – incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. Conclusion: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.

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  • Corrigendum to "Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population." [Atherosclerosis 246 (March 2016) 141-147]. Reviewed

    Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, ACCESS, SESSA Research Groups

    Atherosclerosis   278   336   2018.8

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  • Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). Reviewed

    Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis   25 ( 6 )   477 - 489   2018.6

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    AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization. We examined an independent relationship between each risk factor used in prediction models and CAC score ≥100 by logistic regression. We then divided the participants into quintiles of estimated CHD risk per prediction model to calculate odds ratio of having CAC score ≥100. Receiver operating characteristic curve and c-index were used to examine discriminative ability of prevalent CAC for each prediction model. RESULTS: Age, smoking status, and systolic blood pressure were significantly associated with CAC score ≥100 in the multivariable analysis. The odds of having CAC score ≥100 were higher for those in higher quintiles in all prediction models (p-values for trend across quintiles <0.0001 for all models). All prediction models showed fair and similar discriminative abilities to detect CAC score ≥100, with similar c-statistics (around 0.70). CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population.

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  • Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study. Reviewed

    Mahajan H, Choo J, Masaki K, Fujiyoshi A, Guo J, Hisamatsu T, Evans R, Shangguan S, Willcox B, Okamura T, Vishnu A, Barinas-Mitchell E, Ahuja V, Miura K, Kuller L, Shin C, Ueshima H, Sekikawa A

    Data in brief   17   1091 - 1098   2018.4

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  • Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men Reviewed

    Sentaro Suzuki, Hisatomi Arima, Soichiro Miyazaki, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Takashi Hisamatsu, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Minoru Horie, Kiyoshi Murata, Katsuyuki Miura, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   25 ( 2 )   186 - 198   2018.2

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    <p>Aim: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men.</p><p>Methods: This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire; CAC by computed tomography; and carotid IMT by ultrasonography.</p><p>Results: The prevalence of CAC was 50.0% for participants with sleep duration <5.5 h, 43.9% with 5.5–6.4 h, 50.0% with 6.5–7.4 h, 49.3% with 7.5–8.4 h, and 62.5% with ≥8.5 h. In univariate analysis, participants with sleep duration ≥8.5 h had significantly higher prevalence of CAC than those with 6.5–7.4 h (p=0.043). After adjustment for age and other risk factors, however, the association was not significant (p=0.776). The average IMT was 0.85 mm for participants with sleep duration <5.5 h, 0.83 mm with 5.5–6.4 h, 0.85 mm with 6.5–7.4 h, 0.88 mm with 7.5–8.4 h, and 0.90 mm with ≥8.5 h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p>0.1).</p><p>Conclusion: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men.</p>

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  • Association of alcohol consumption and aortic calcification in healthy men aged 40–49 years for the ERA JUMP Study Reviewed

    Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Takashi Hisamatsu, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Tomonori Okamura, Abhishek Vishnu, Emma Barinas-Mitchell, Vasudha Ahuja, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

    Atherosclerosis   268   84 - 91   2018.1

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    Background and aims Several studies have reported a significant inverse association of light to moderate alcohol consumption with coronary heart disease (CHD). However, studies assessing the relationship between alcohol consumption and atherosclerosis have reported inconsistent results. The current study was conducted to determine the relationship between alcohol consumption and aortic calcification. Methods We addressed the research question using data from the population-based ERA-JUMP Study, comprising of 1006 healthy men aged 40–49 years, without clinical cardiovascular diseases, from four race/ethnicities: 301 Whites, 103 African American, 292 Japanese American, and 310 Japanese in Japan. Aortic calcification was assessed by electron-beam computed tomography and quantified using the Agatston method. Alcohol consumption was categorized into four groups: 0 (non-drinkers), ≤1 (light drinkers), &gt
    1 to ≤3 (moderate drinkers) and &gt
    3 drinks per day (heavy drinkers) (1 drink = 12.5 g of ethanol). Tobit conditional regression and ordinal logistic regression were used to investigate the association of alcohol consumption with aortic calcification after adjusting for cardiovascular risk factors and potential confounders. Results The study participants consisted of 25.6% nondrinkers, 35.3% light drinkers, 23.5% moderate drinkers, and 15.6% heavy drinkers. Heavy drinkers [Tobit ratio (95% CI) = 2.34 (1.10, 4.97)
    odds ratio (95% CI) = 1.67 (1.11, 2.52)] had significantly higher expected aortic calcification score compared to nondrinkers, after adjusting for socio-demographic and confounding variables. There was no significant interaction between alcohol consumption and race/ethnicity on aortic calcification. Conclusions Our findings suggest that heavy alcohol consumption may be an independent risk factor for atherosclerosis.

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  • Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men Reviewed

    Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa

    BRITISH JOURNAL OF NUTRITION   117 ( 2 )   260 - 266   2017.1

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    Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol &gt;83 nm. The presence of CAC was defined as a coronary Ca score 10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 5127 (interquartile range (IQR) 1941, 11700), 91 (IQR 010, 331) and 00 (IQR 00, 10) nm, respectively. Prevalence of CAC and equol-producers was 96 and 160 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 010 (95 % CI 001, 090, P&lt;004). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.

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  • The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men Reviewed

    Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Abhisek Vishnu, Aya Kadota, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Rhobert W. Evans, Bradley J. Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

    JOURNAL OF HYPERTENSION   35 ( 1 )   111 - 117   2017.1

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    Objective: A few studies have examined the longitudinal association of blood pressure (BP) with arterial stiffness progression, and the results were inconsistent. The objective of this study was to investigate the roles of initial BP and its longitudinal change on the progression of arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV).
    Method: Study participants (n = 656) were from population-based samples of healthy men aged 40-49 years at baseline (213 White Americans, 47 AfricanAmericans, 152 Japanese Americans and 244 Japanese in Japan). BP measures, baPWV and other factors were examined at baseline and 4-7 years later. General linear regression was applied for statistical analyses.
    Result: Annual change in SBP (standardized coefficient: 0.33, P&lt;0.001), but not its baseline level (standardized coefficient: 0.03, P = 0.495), had a positive significant association with the progression of baPWV after adjusting for a wide range of standard cardiovascular risk factors. Similarly, annual changes in DBP (standardized coefficient: 0.35, P&lt;0.001), pulse pressure (standardized coefficient: 0.15, P = 0.001) and mean arterial pressure (standardized coefficient: 0.37, P&lt;0.001) were positively associated with the progression of baPWV. None of the baseline measures were related to the progression of baPWV.
    Conclusion: Our findings imply that, regardless of initial BP, effective monitoring and controlling of BP is important to slow down arterial wall stiffening and hence reduce cardiovascular risk.

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  • Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). Reviewed International journal

    Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Koichiro Azuma, Sachiko Tanaka, Takashi Hisamatsu, Hisatomi Arima, Aya Kadota, Naoko Miyagawa, Naoyuki Takashima, Takayoshi Ohkubo, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima

    Preventive medicine reports   4   225 - 32   2016.12

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    Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40-64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m(2) (median, 23.5 kg/m(2)). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001-0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009-0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated.

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  • Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers Reviewed

    Yasuharu Tabara, Hirotsugu Ueshima, Naoyuki Takashima, Takashi Hisamatsu, Akira Fujiyoshi, Maryam Zaid, Masaki Sumi, Katsuhiko Kohara, Tetsuro Miki, Katsuyuki Miura

    ATHEROSCLEROSIS   254   242 - 248   2016.11

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    Background and aims: While alcohol consumption is known to increase plasma high-density lipoprotein (HDL) cholesterol levels, its relationship with low-density lipoprotein (LDL) cholesterol levels is unclear. Aldehyde dehydrogenase 2 (ALDH2) is a rate-controlling enzyme in alcohol metabolism, but a large number of Japanese people have the inactive allele. Here, we conducted a Mendelian randomization analysis using the ALDH2 genotype to clarify a causal role of alcohol on circulating cholesterol levels and lipoprotein particle numbers.
    Methods: This study was conducted in three independent general Japanese populations (men, n = 2289; women, n = 1940; mean age 63.3 +/- 11.2 years). Alcohol consumption was assessed using a questionnaire. Lipoprotein particle numbers were determined by nuclear magnetic resonance spectroscopy.
    Results: Alcohol consumption increased linearly in proportion to the number of subjects carrying the enzymatically active *1 allele in men (p &lt; 0.001). The *1 allele was also positively associated with HDL cholesterol level (adjusted mean +/- standard error, *1*1: 60 +/- 0.5, *1*2: 56 +/- 0.6, *2*2: 55 +/- 1.3 mg/dl, p &lt; 0.001) and inversely associated with LDL cholesterol level (116 +/- 0.9, 124 +/- 1.1, 130 +/- 2.6 mg/dl, p &lt; 0.001). The *1 allele was also positively associated with HDL particle numbers (per-allele: 2.60 +/- 0.32 mmol/l, p &lt; 0.001) and inversely associated with LDL particle numbers (-67.8 +/- 19.6 nmol/l, p = 0.001). Additional Mendelian randomization analysis failed to clarify the involvement of cholesteryl ester transfer protein in alcohol-related changes in lipoprotein cholesterol levels. No significant association was observed in women, presumably due to their small amount of alcohol intake.
    Conclusions: Alcohol consumption has a causal role in not only increasing HDL cholesterol levels but also decreasing LDL cholesterol levels and particle numbers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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  • Early repolarization and risk of arrhythmia events in long QT syndrome Reviewed

    Kanae Hasegawa, Hiroshi Watanabe, Takashi Hisamatsu, Seiko Ohno, Hideki Itoh, Takashi Ashihara, Hideki Hayashi, Takeru Makiyama, Tohru Minamino, Minoru Horie

    INTERNATIONAL JOURNAL OF CARDIOLOGY   223   540 - 542   2016.11

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  • Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification Reviewed

    Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D. Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 5 )   1195 - 1202   2016.10

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    BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).
    OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDLC, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.
    METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; &gt;0 Agatston score) were examined.
    RESULTS: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.
    CONCLUSIONS: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P. (C) 2016 National Lipid Association. All rights reserved.

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  • Lipoprotein-associated phospholipase A(2) is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population Reviewed

    Hirotsugu Ueshima, Takashi Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Akira Sekikawa, Aya Kadota, Sayaka Kadowaki, Yasuyuki Nakamura, Naoko Miyagawa, Tomonori Okamura, Yoshikuni Kita, Naoyuki Takashima, Atsunori Kashiwagi, Hiroshi Maegawa, Minoru Horie, Takashi Yamamoto, Takeshi Kimura, Toru Kita

    ATHEROSCLEROSIS   246   141 - 147   2016.3

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    Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL). Lp-PLA2 is recognized as playing a key role in inflammatory processes and the development of atherosclerosis. This study aimed to investigate whether Lp-PLA2 is related to subclinical atherosclerosis, independently from traditional risk factors, in a general Japanese population by analyses of both the observational study and Mendelian randomization using V279F polymorphism.
    Methods and results: We cross-sectionally examined community-based sample of 929 Japanese men aged 40-79 years, without statin treatment, who were randomly selected from the resident registration. Multiple regression analyses of Lp-PLA2 activity and concentration were undertaken separately for men aged 40-49 years and 50-79 years, to clarify interactions of age and Lp-PLA2. Lp-PLA2 activity for men aged 50-79 years was significantly and positively related to intima-media thickness (IMT) (P = 0.013) and plaque index (P = 0.008) independent of traditional risk factors including small LDL particles, but not to coronary artery calcification (CAC) score. Associations with Lp-PLA2 concentration were qualitatively similar to those of activity. Corresponding relationships were not observed in men aged 40e49 years. Mendelian randomization analyses based on V279F genotype did not show any significant associations with subclinical atherosclerosis, although the homozygote and heterozygote of V279F showed low LpPLA2 activity and concentration.
    Conclusions: Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that LpPLA2 is a causative factor for subclinical atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  • Pediatric Cohort With Long QT Syndrome-KCNH2 Mutation Carriers Present Late Onset But Severe Symptoms - Reviewed

    Junichi Ozawa, Seiko Ohno, Takashi Hisamatsu, Hideki Itoh, Takeru Makiyama, Hiroshi Suzuki, Akihiko Saitoh, Minoru Horie

    CIRCULATION JOURNAL   80 ( 3 )   696 - 702   2016.3

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    Background: In children with long QT syndrome (LQTS), risk factors for cardiac events have been reported, but age-, gender-and genotype-related differences in prognosis remain unknown in Asian countries.
    Methods and Results: The study examined clinical prognosis at age between 1 and 20 years in 496 LQTS patients who were genotyped as either of LQT1-3 (male, n=206). Heterozygous mutations were observed in 3 major responsible genes: KCNQ1 in 271, KCNH2 in 192, and SCN5A in 33 patients. LQTS-associated events were classified into 3 categories: (1) syncope (n=133); (2) repetitive torsade de pointes (TdP, n=3); and (3) cardiopulmonary arrest (CPA, n=4). The risk of cardiac events was significantly lower in LQT1 girls than boys &lt;= 12 years (HR, 0.55), whereas LQT2 female patients &gt;= 13 years had the higher risk of cardiac events than male patients (HR, 4.60). Patients in the repetitive TdP or CPA group included 1 LQT1 female patient, 1 LQT2 male patient, and 5 LQT2 female patients. All LQT2 patients in these groups had TdP repeatedly immediately after the antecedent event. In addition, all 5 female LQT2 patients in these groups had the event after or near puberty.
    Conclusions: Female LQT2 children might have repeated TdP shortly after prior events, especially after puberty.

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  • Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese Reviewed

    Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima

    JOURNAL OF CLINICAL LIPIDOLOGY   10 ( 1 )   172 - 180   2016.2

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    BACKGROUND: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations.
    METHODS: A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody.
    RESULTS: Serum LAB levels (median [interquartile range], mu g cs/L) were 5341 mu g cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 mu m) compared with the first quartile (797 mu m) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC &gt;= 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 mu m (12.7), 856 mu m (16.7) in the low LAB/hypercholesterolemia group, and 833 mu m (8.4) in the low LAB/normal cholesterol group (P = .004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication.
    CONCLUSION: Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia. (C) 2016 National Lipid Association. All rights reserved.

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  • High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia Reviewed

    Keiko Sonoda, Hiroshi Watanabe, Takashi Hisamatsu, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Minoru Horie, Tohru Minamino

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   21 ( 1 )   30 - 40   2016.1

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    BackgroundJ wave, or early repolarization has recently been associated with an increased risk of lethal arrhythmia and sudden death, both in idiopathic ventricular fibrillation and in the general population. Hypercalcemia is one of the causes of J point and ST segment elevation, but the relationship has not been well studied. The aim of this study was to examine the effects of hypercalcemia on J point elevation.
    MethodsElectrocardiographic findings were compared in 89 patients with hypercalcemia and 267 age- and sex-matched healthy controls with normocalcemia. The association of J point elevation with arrhythmia events in patients with hypercalcemia was also studied.
    ResultsThe PR interval and the QRS duration were longer in patients with hypercalcemia than in normocalcemic controls. Both the QT and the corrected QT intervals were shorter in patients with hypercalcemia compared with normocalcemic controls. Conduction disorders, ST-T abnormalities, and J point elevation were more common in patients with hypercalcemia than normocalcemic controls. Following the resolution of hypercalcemia, the frequency of J point elevation decreased to a level similar to that noted in controls. During hospitalization, no arrhythmia event occurred in patients with hypercalcemia.
    ConclusionHypercalcemia was associated with J point elevation.

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  • Association between pulse wave velocity and coronary artery calcification in Japanese men the shiga epidemiological study of subclinical atherosclerosis (SESSA Reviewed

    Sayuki Torii, Hisatomi Arima, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saito, Naoko Miyagawa, Maryam Zaid, Yoshitaka Murakami, Robert D. Abbott, Minoru Horie, Katsuyuki Miura, SESSA Research Group, Hirotsugu Ueshima

    Journal of Atherosclerosis and Thrombosis   22 ( 12 )   1266 - 1277   2015.12

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    Aim: Pulse wave velocity (PWV is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC is an intermediate stage in the process leading to overt cardiovascular disease (CVD and an established determinant of coro nary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. Methods: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores ≥ 10 were defined as the presence of CAC. Results: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles <1378, 1378-1563, 1564-1849, and >1849 cm/s (P< 0.001 for trend. Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P= 0.042 for trend. The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. Conclusions: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.

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  • Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men Reviewed

    Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J. M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY   189   67 - 72   2015.6

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    Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men.
    Methods: A population-based sample of 1131men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as &gt;= 10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV.
    Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p &lt; 0.01), or by 36% per standard-deviation increase (p &lt; 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans.
    Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacks in the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  • High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men Reviewed

    Maryam Zaid, SESSA Research group, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Emiko Ogawa, Itsuko Miyazawa, Kiyoshi Murata, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Emma Barinas-Mitchell, Daniel Edmundowicz, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Takashi Kadowaki, Sayaka Kadowaki, Yoshitaka Murakami, Seiko Ohno

    Atherosclerosis   239 ( 2 )   444 - 450   2015.4

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    The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P&lt
    0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.

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  • Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study Reviewed

    S. R. El Khoudary, C. Shin, K. Masaki, K. Miura, M. Budoff, D. Edmundowicz, S. Kadowaki, E. Barinas-Mitchell, A. El-Saed, A. Fujiyoshi, R. W. Evans, T. Hisamatsu, T. Ohkubo, B. J. Willcox, L. H. Kuller, H. Ueshima, A. Sekikawa

    INTERNATIONAL JOURNAL OF OBESITY   39 ( 3 )   488 - 494   2015.3

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    BACKGROUND/OBJECTIVES: Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.
    SUBJECTS/METHODS: Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).
    RESULTS: Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values &lt; 0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value &lt; 0.05).
    CONCLUSIONS: Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.

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  • Comparison of HOMA-IR, HOMA-beta% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study Reviewed

    Vasudha Ahuja, Takashi Kadowaki, Rhobert W. Evans, Aya Kadota, Tomonori Okamura, Samar R. El Khoudary, Akira Fujiyoshi, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Abhishek Vishnu, Katsuyuki Miura, Hiroshi Maegawa, Aiman El-Saed, Atsunori Kashiwagi, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    DIABETOLOGIA   58 ( 2 )   265 - 271   2015.2

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    At the same level of BMI, white people have less visceral adipose tissue (VAT) and are less susceptible to developing type 2 diabetes than Japanese people. No previous population-based studies have compared insulin resistance and insulin secretion between these two races in a standardised manner that accounts for VAT. We compared HOMA-IR, HOMA of beta cell function (HOMA-beta%) and disposition index (DI) in US white men and Japanese men in Japan.
    We conducted a population-based, cross-sectional study, comprising 298 white men and 294 Japanese men aged 40-49 years without diabetes. Insulin, glucose, VAT and other measurements were performed at the University of Pittsburgh. We used ANCOVA to compare geometric means of HOMA-IR, HOMA-beta% and DI, adjusting for VAT and other covariates.
    White men had higher HOMA-IR, HOMA-beta% and DI than Japanese men, and the difference remained significant (p &lt; 0.01) after adjusting for VAT (geometric mean [95% CI]): 3.1 (2.9, 3.2) vs 2.5 (2.4, 2.6), 130.8 (124.6, 137.3) vs 86.7 (82.5, 91.0), and 42.4 (41.0, 44.0) vs 34.8 (33.6, 36.0), respectively. Moreover, HOMA-IR, HOMA-beta% and DI were significantly higher in white men even after further adjustment for BMI, impaired fasting glucose and other risk factors.
    The higher VAT-adjusted DI in white men than Japanese men may partly explain lower susceptibility of white people than Japanese people to developing type 2 diabetes. The results, however, should be interpreted with caution because the assessment of insulin indices was made using fasting samples and adjustment was not made for baseline glucose tolerance. Further studies using formal methods to evaluate insulin indices are warranted.

    DOI: 10.1007/s00125-014-3414-6

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  • Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study Reviewed

    Shin-ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   22 ( 6 )   590 - 598   2015

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    Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians.
    Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models.
    Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all &lt; 0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC.
    Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.

    DOI: 10.5551/jat.23580

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  • Long-term outcomes associated with prolonged PR interval in the general Japanese population Reviewed

    Takashi Hisamatsu, NIPPON DATA80 Research Group, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-Ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Fumiyoshi Kasagi, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshitaka Murakami, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara

    International Journal of Cardiology   184 ( 1 )   291 - 293   2015

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    Authorship:Lead author, Corresponding author   Language:English   Publisher:Elsevier Ireland Ltd  

    DOI: 10.1016/j.ijcard.2015.02.028

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  • Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis Reviewed

    Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Kadowaki, Sayaka Kadowaki, Maryam Zaid, Takashi Hisamatsu, Akira Sekikawa, Matthew J. Budoff, Kiang Liu, Hirotsugu Ueshima

    AMERICAN JOURNAL OF EPIDEMIOLOGY   180 ( 6 )   590 - 598   2014.9

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    The incidence of coronary heart disease in the United States has declined, and prevalences of several coronary disease risk factors have become comparable to those in Japan. Therefore, the burden of coronary atherosclerosis may be closer among younger persons in the 2 countries. We aimed to compare prevalences of coronary atherosclerosis, measured with coronary artery calcium scores, between men in the 2 countries by age group (45-54, 55-64, or 65-74 years). We used community-based samples of Caucasian men in the United States (2000-2002; n = 1,067) and Japanese men in Japan (2006-2008; n = 832) aged 45-74 years, stratifying them into groups with 0, 1, 2, or &gt;= 3 of the following risk factors: current smoking, overweight, diabetes, dyslipidemia, and hypertension. We calculated adjusted odds ratios of US Caucasian men's having Agatston scores of &gt;= 10, &gt;= 100, and &gt;= 400 with reference to Japanese men. Overall, the odds of Caucasian men having each Agatston cutoff point were greater. The ethnic difference, however, became smaller in younger age groups. For example, adjusted odds ratios for Caucasian men's having an Agatston score of &gt;= 100 were 2.05, 2.43, and 3.86 among those aged 45-54, 55-64, and 65-74 years, respectively. Caucasian men in the United States had a higher burden of coronary atherosclerosis than Japanese men, but the ethnic difference was smaller in younger age groups.

    DOI: 10.1093/aje/kwu169

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  • Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80 Reviewed

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    ATHEROSCLEROSIS   232 ( 2 )   384 - 389   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Background: Dietary intake of long-chain n-3 PUFA (LCn3FA) among Japanese is generally higher than that in Western populations. However, little is known whether an inverse association of LCn3FA with cardiovascular disease (CVD) risk exists in a population with higher LCn3FA intake.
    Objective: To investigate the association between LCn3FA intake and the long-term risk of CVDs in a Japanese general population.
    Methods: We followed-up a total of 9190 individuals (56.2% women, mean age 50.0 years) randomly selected from 300 areas across Japan and free from CVDs at baseline. Dietary LCn3FA intake was estimated using household weighed food records. Cox models were used to calculate multivariate-adjusted hazard ratios (HR) and confidence intervals (CI) according to sex specific quartiles of LCn3FA intake.
    Results: During 24-year follow-up (192,897 person-years), 879 cardiovascular deaths were observed. The median daily intake of LCn3FA was 0.37% kcal (0.86 g/day). Adjusted HR for CVD mortality was lower in the highest quartile of LCn3FA intake (HR 0.80; 95% CI 0.66-0.96) compared with the lowest quartile, and the trend was statistically significant (P = 0.038). The similar but statistically non-significant trends were observed for coronary heart disease death and stroke death. In analyses by age groups, the inverse associations of LCn3FA intake with the risk of total CVD death and stroke death were significant in younger individuals (30-59 years at baseline).
    Conclusion: LCn3FA intake was inversely and independently associated the long-term risk of total CVD mortality in a representative sample of Japanese with high LCn3FA intake. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.atherosclerosis.2013.11.073

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  • Long-chain n-3 Polyunsaturated Fatty Acids Intake and Cardiovascular Disease Mortality Risk in a General Japanese Population: NIPPON DATA80 Reviewed

    Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

    STROKE   44 ( 2 )   2013.2

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  • Is More Aggressive Prevention of Coronary Artery Disease Required for Patients With Early Repolarization Syndrome? (Letter) Reviewed

    Hisamatsu T, Ohkubo T, Miura K, Horie M, Ueshima H

    Circ J   77 ( 6 )   1643   2013

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  • Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Reviewed

    Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H

    J Atheroscler Thromb.?   20 ( 10 )   755 - 766   2013

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  • Long-term risk of BP values above normal for cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years. Reviewed International journal

    Naoyuki Takashima, Takayoshi Ohkubo, Katsuyuki Miura, Tomonori Okamura, Yoshitaka Murakami, Akira Fujiyoshi, Shin-Ya Nagasawa, Aya Kadota, Yoshikuni Kita, Naoko Miyagawa, Takashi Hisamatsu, Takehito Hayakawa, Akira Okayama, Hirotsugu Ueshima

    Journal of hypertension   30 ( 12 )   2209 - 2306   2012

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    OBJECTIVE: In Western populations, blood pressure (BP) measured at baseline has been reported to predict long-term (over 20 years) risk of mortality from cardiovascular diseases (CVDs). However, corresponding evidence is scarce in Asia where stroke is dominant. We investigated the association between baseline BP and 24-year mortality risk due to CVD, in a representative Japanese general population. METHODS: We followed up a nationwide sample of 8592 Japanese, aged 30 years or above without a history of CVD and antihypertensive medication at baseline, for 24 years. Hazard ratios for CVD mortality in BP categories defined according to JCN7 criteria were estimated using Cox model adjusted for potential confounding factors with normal BP treated as the reference category. RESULTS: We observed 689 CVD deaths. Hazard ratios for CVD mortality were progressively and significantly increased from the category of prehypertension. Population-attributable fraction (PAF) demonstrated that 43 and 48% of CVD and stroke deaths were explained by non-normal BP at baseline. Hazard ratios and PAF were remarkably higher in younger participants (aged 30-59 years) than those in the elderly (aged 60 years or above). Particularly, in younger men, 81% of CVD deaths were explained by non-normal BP. In sensitivity analysis, participants with antihypertensive medication showed the highest hazard ratio for CVD morality compared with the other categories. CONCLUSIONS: BP levels above normal at baseline retained significant relative and absolute risks of CVD and stroke mortality during 24 years. Long-lasting burden of non-normal BP particularly in younger individuals suggests the importance of primary prevention of high BP from younger generation.

    DOI: 10.1097/HJH.0b013e328359a9f7

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  • The effect of angiotensin converting enzyme inhibitor, imidapril, on reducing proteinuria in the patient with lupus nephritis: A case report Reviewed

    下垣保恵, 筒井崇, 大平直人, 久松隆史, 田中雅博, 望月裕司, 豊田嘉清, 中井直治, 竹内孝男, 郡山健治, 河野厚

    臨床リウマチ   22 ( 4 )   389 - 393   2010

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Books

  • 循環器病予防エビデンスブック

    久松隆史( Role: Contributor ,  心疾患の動向)

    医歯薬出版  2021.6 

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  • 健康教育マニュアル第2版

    ( Role: Contributor ,  血圧測定法の種類と血圧分類; 高血圧薬物治療の原則)

    日本家族計画協会  2019.11 

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  • Tobacco and Cardiovascular Disease. Vasan R and Sawyer D (Edit.). Encyclopedia of Cardiovascular Research and Medicine

    Kanda H, Hisamatsu T(537-544)

    Elsevier  2017 

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  • 健康教育マニュアル

    久松隆史( Role: Contributor ,  血圧測定法の種類と血圧分類; 高血圧薬物治療の原則)

    日本家族計画協会  2014 

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MISC

  • 飲酒と冠動脈石灰化・冠動脈疾患発症との関連 メンデルランダム化分析 Reviewed

    久松 隆史, 三浦 克之, 田原 康玄, 門脇 崇, 鳥居 さゆ希, 門田 文, 近藤 慶子, 藤吉 朗, 山本 孝, 中川 義久, 堀江 稔, 木村 剛, 岡村 智教, 上島 弘嗣

    日本アルコール・薬物医学会雑誌   56 ( 6 )   281 - 281   2021.12

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:(一社)日本アルコール・アディクション医学会  

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  • 海外留学ネットワーキングセミナー Invited

    久松隆史

    第84回日本循環器学会学術集会   2020.7

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  • 【最新の高血圧診療:「高血圧治療ガイドライン2019」後の展開】高血圧の成因、分類、疫学 高血圧の疫学

    久松 隆史, 三浦 克之

    診断と治療   108 ( 4 )   445 - 451   2020.4

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    Language:Japanese   Publisher:(株)診断と治療社  

    <Headline>1 国民の収縮期血圧平均値は、男女ともいずれの年齢階級においても過去約60年で大きく低下した一方、拡張期血圧平均値は、特に60歳未満の男性では低下傾向が明らかではない。2 高血圧有病率は依然高く、50歳以上の男性、60歳以上の女性ではおおよそ60%以上である状態が続いている。3 高血圧管理率は改善傾向にあるものの、男性では約40%、女性では約45%にとどまっており、現在のところ降圧薬内服者の半数以上は管理不十分である。4 2017年の高血圧者の推計数は計4,300万人、うち3,100万人(72%)が管理不良であった。5 日本国民の血圧水準、高血圧有病率、および高血圧管理率をさらに改善させるには、高血圧者に対するハイリスクアプローチと、国民全体でのポピュレーションアプローチを組み合わせた総合的な対策の積極的な推進が重要である。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00697&link_issn=&doc_id=20200422190004&doc_link_id=%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2020%2F010804%2F006%2F0445-0451%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 【高血圧診療update-診断・治療の最新動向-】わが国の高血圧の疫学

    久松 隆史, 三浦 克之

    日本臨床   78 ( 2 )   204 - 209   2020.2

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    Language:Japanese   Publisher:(株)日本臨床社  

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  • The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Invited

    Hisamatsu T, Ohkubo T, Kadota A, Fujiyoshi A, Miura K, Ueshima H

    IDACO/IDHOCO/IDCARS Consortium Meeting 2019   2019.10

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  • 島根県益田市におけるIoTを活用した血圧管理プロジェクト Invited

    久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    第1回Digital Hypertension Conference   2019.10

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  • 【循環器疾患を予防する】リスク因子の集積・メタボリックシンドロームと循環器疾患

    久松 隆史

    公衆衛生   83 ( 5 )   350 - 355   2019.5

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    Language:Japanese   Publisher:(株)医学書院  

    <文献概要>はじめに 循環器疾患の古典的なリスク因子である肥満,高血圧,糖尿病,脂質異常症が合併しやすいことは以前から知られていた.現在では,腹部肥満,特に内臓脂肪型肥満(インスリン抵抗性)を基盤として,血圧上昇,血糖高値,脂質異常が集積した病態が「メタボリックシンドローム」(metabolic syndrome)と定義されている.肥満が原因となって,先述のリスク因子が軽度でも集積して存在すると循環器疾患リスクが高くなることが知られており,メタボリックシンドロームは循環器疾患の一次予防において重要な概念となっている.わが国では,欧米諸国と比較して肥満者割合が依然として低い一方で,肥満を伴わないリスク因子保有・集積者における循環器疾患リスクがメタボリックシンドローム有所見者のそれと同等か,それよりも高いことが報告されるなど,非肥満者におけるリスク因子保有・集積の重要性が認識されている.本稿は,リスク因子の集積に焦点を当て,わが国の疫学研究成果を踏まえて循環器疾患への影響を検討する.さらに,循環器疾患一次予防に関する包括的なリスク評価と,公衆衛生上の対策について概説する.

    J-GLOBAL

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00447&link_issn=&doc_id=20190507110008&doc_link_id=10.11477%2Fmf.1401209138&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1401209138&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA Invited

    Takashi Hisamatsu

    Cardiovascular Epidemiology Seminar Series   2019.1

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  • 【動脈硬化とカルシウム〜カルシウムパラドックスの謎に迫る〜】一次予防における冠動脈石灰化の意義

    久松 隆史, 藤吉 朗, 三浦 克之

    Clinical Calcium   29 ( 2 )   215 - 223   2019.1

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    Language:Japanese   Publisher:(株)医薬ジャーナル社  

    <文献概要>潜在性動脈硬化指標の一つとして,単純CTにより定量的に評価された冠動脈石灰化がある。一次予防において,危険因子への長期曝露の結果である冠動脈石灰化所見を用いることで,有効に動脈硬化性心血管病の発症を予測し,中等度リスク保有者の管理において治療方針の決定などリスクの層別化を行い得る可能性が検討されている。また,冠動脈石灰化は動脈硬化進展マーカーとしても用いられる。一方,冠動脈石灰化測定の費用対効果や放射線被曝の問題などでは確定的な結論が得られていない。一次予防における冠動脈石灰化の有用性の確立のために,わが国を含む冠動脈石灰化に関する研究の更なる発展およびエビデンスの集積が望まれる。

    J-GLOBAL

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02593&link_issn=&doc_id=20190204290010&doc_link_id=10.20837%2F4201902215&url=https%3A%2F%2Fdoi.org%2F10.20837%2F4201902215&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松隆史, 三浦克之, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 早川岳人, 神田秀幸, 岡村智教, 岡村智教, 岡山明, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   302 - 302   2019

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    Language:Japanese   Publisher:(NPO)日本高血圧学会  

    J-GLOBAL

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  • Coronary artery calcium: Its clinical utility in primary prevention

    Hisamatsu T, Fujiyoshi A, Miura K

    Clin Calcium   29 ( 2 )   215 - 223   2019

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  • (循環器病予防総説シリーズ 6:記述疫学編 2)わが国における心疾患の死亡率・罹患率の動向 Reviewed

    久松隆史, 三浦克之

    日本循環器病予防学会誌   53 ( 1 )   1 - 8   2018

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:(一社)日本循環器病予防学会  

    日本における衛生統計・地域の疫学調査成績や国際比較を通じて、心疾患の中でも死亡率が高く疫学的知見の豊富な冠動脈疾患を中心に、その危険因子も含めて時代的な推移を概説した。心疾患全体での粗死亡率が上昇している一方、急性心筋梗塞を含む冠動脈疾患の粗死亡率は必ずしも上昇していない。また、冠動脈疾患を年齢調整死亡率で比較すると、日本は依然男女とも世界の中で最低水準と考えられた。一方で、急性心筋梗塞罹患率の都市部、男性における増加傾向が一部の疫学研究から示されており、その死亡率も近い将来上昇傾向に転じる可能性が懸念された。

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  • アテローム動脈硬化性心血管疾患予防における冠動脈石灰化(Coronary Artery Calcification for Prevention of Atherosclerotic Cardiovascular Disease)

    Hisamatsu Takashi

    Shimane Journal of Medical Science   34 ( 1 )   1 - 5   2017.7

  • 動脈・静脈疾患の疫学 血管疾患の疫学-国際比較-

    久松隆史, 三浦克之

    日本臨床   75 ( 増刊4 動脈・静脈の疾患(上) )   43 - 50   2017

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    久松隆史

    上原記念生命科学財団研究報告集(CD-ROM)   31   1 - 6   2017

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  • 潜在性動脈硬化症の疫学 5)喫煙の潜在性動脈硬化への影響

    久松隆史

    動脈硬化予防   16 ( 3 )   32 - 36   2017

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    喫煙は動脈硬化性心血管病(atherosclerotic cardiovascular disease;ASCVD)に対する最大の予防可能な危険因子である。ASCVD発症前の一般健常集団において、喫煙習慣(現在喫煙・禁煙)、特に現在喫煙は、冠動脈・頸動脈・大動脈・末梢動脈を含む全身の潜在性動脈硬化の進展と強固に関連し、これらの進展は生涯喫煙量(pack-year)の多い喫煙者・禁煙者ほど大きく、一方、早期に禁煙した禁煙者ほど生涯非喫煙者に近づくものと考えられる。欧米諸国と比較して依然喫煙率が高いわが国におけるASCVDのさらなる予防のためには、防煙ならびに喫煙者における早期の禁煙の積極的な推進が重要である。(著者抄録)

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  • 冠動脈疾患と降圧療法 冠動脈疾患と高血圧(疫学)

    久松隆史, 三浦克之

    血圧   23 ( 7 )   460 - 465   2016

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    高血圧は、冠動脈疾患を含む心血管病の代表的な危険因子であり、日常診療で最もよく遭遇する疾患である。人口の急速な高齢化や生活習慣の欧米化の進展に伴い、都市部を中心とした冠動脈疾患発症率の増加および、とくに男性における高血圧有病率の上昇が今後懸念され、またアジア人では冠動脈疾患に対する高血圧の寄与度は大きいことから、わが国における冠動脈疾患予防に関して、高血圧対策が重要であると再認識する必要がある。至適血圧を超えて血圧が高くなるほど冠動脈疾患の死亡・発症リスクは高くなり、わが国における冠動脈疾患死亡の50%以上が至適血圧を超える血圧高値に起因するものと推定される。ポピュレーションアプローチを用いて国民全体の収縮期血圧平均値を4mmHg低下させることにより、冠動脈疾患死亡数が年間約5千人減少すると推計される。(著者抄録)

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  • 身近に考えよう 循環器内科の素朴な疑問 検査 1):心電図 Question02 健康診断で心電図異常を認めた際,どのような所見がある場合に専門医に依頼すべきでしょうか?たとえば,期外収縮でも紹介すべきですか?脚ブロックやR波増高不良,Brugada型心電図などで悩むことが多くあります.

    久松隆史

    治療   98 ( 3 )   333 - 336   2016

  • 心電図におけるJ-point上昇と生命予後の関係

    久松 隆史, 三浦 克之

    日本医事新報   ( 4750 )   58 - 59   2015.5

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  • 潜在性動脈硬化の規定要因:ERA JUMP,SESSAより

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   47th   119 - 119   2015

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  • 高血圧の疫学から学ぶ公衆衛生の役割と展望

    久松隆史, 三浦克之

    Heart View   19 ( 4 )   25 - 33   2015

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  • 危険因子 Lp-PLA2

    久松隆史, 上島弘嗣, 三浦克之

    動脈硬化予防   14 ( 1 )   113 - 118   2015

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  • 高血圧治療ガイドラインJSH2014改訂と高血圧治療の展望 4 高血圧の疫学から学ぶ公衆衛生の役割と展望

    HISAMATSU TAKASHI, MIURA KATSUYUKI

    Heart View   19 ( 4 )   361 - 369   2015

  • 我が国におけるHDLコレステロール値の推移とその関連要因の疫学的検討:NIPPON DATA・循環器疾患基礎調査を用いた統合データ解析,1990‐2010年

    HISAMATSU TAKASHI, OJIMA TOSHIYUKI, NAKAMURA YASUYUKI, KIYOHARA YUTAKA, NAKAGAWA HIDEAKI, KUWABARA KAZUYO, FUJIYOSHI AKIRA, KADOTA AYA, OKUBO TAKAYOSHI, OKAMURA TOMONORI, UESHIMA HIROTSUGU, OKAYAMA AKIRA, MIURA KATSUYUKI

    日本循環器病予防学会誌   50 ( 2 )   142 - 142   2015

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  • 高血圧診療のup to date 高血圧の疫学

    久松隆史, 三浦克之

    月刊臨床と研究   91 ( 1 )   1 - 8   2014

  • 高血圧治療ガイドラインJSH2014 2)疫学

    久松隆史, 三浦克之

    動脈硬化予防   13 ( 3 )   11 - 17   2014

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  • 疫学 脳卒中疫学の国際比較

    久松隆史, 大久保孝義, 三浦克之

    日本臨床   72 ( 増刊5 最新臨床脳卒中学(上) )   44 - 51   2014

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  • 【多リスク時代の新しいストラテジー トータル血管マネージメント】日本人の脳卒中、心筋梗塞、腎臓病に対するリスク因子の寄与度の違い わが国の疫学研究から

    久松 隆史, 大久保 孝義, 堀江 稔, 三浦 克之

    Mebio   27 ( 10 )   30 - 44   2010.10

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  • 高血圧症と社会要因との関連 益田研究から

    福田 茉莉, 久松 隆史, 絹田 皆子, 中畑 典子, 谷口 かおり, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   111 - 111   2022.1

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  • 一般集団における潜在性動脈硬化の実態解明と規定要因の探索のための疫学研究 Invited

    久松 隆史

    Journal of Epidemiology   32 ( Suppl.1 )   86 - 86   2022.1

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  • 2年間の前向き地域研究からみた室温・外気温が家庭血圧に与える影響 益田研究

    絹田 皆子, 久松 隆史, 福田 茉莉, 谷口 かおり, 中畑 典子, 神田 秀幸

    Journal of Epidemiology   32 ( Suppl.1 )   126 - 126   2022.1

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  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90

    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ

    Journal of Epidemiology   32 ( Suppl.1 )   124 - 124   2022.1

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  • 公衆衛生の観点からみたアディクション 公衆衛生の観点からみたインターネット嗜癖・ゲーム障害

    神田 秀幸, 福田 茉莉, 絹田 皆子, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   150 - 150   2021.12

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  • 障害(disorder,disability,dysfunction)と疾患(disease):どこが違うのか? 公衆衛生学的な観点からみたdiseaseとdisorderの考え方

    神田 秀幸, 久松 隆史

    日本アルコール・薬物医学会雑誌   56 ( 6 )   131 - 131   2021.12

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  • 地域一般住民における自己採血型簡易血液検査(指先採血)の導入と実施状況

    神田 秀幸, 久松 隆史, 福田 茉莉, 絹田 皆子, 中畑 典子, 谷口 かおり, 杉山 大典, 岡村 智教

    日本公衆衛生学会総会抄録集   80回   356 - 356   2021.11

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  • 地域におけるIoT高血圧管理研究が高血圧有病率・認知率・治療率・管理率へ与える影響

    久松 隆史, 福田 茉莉, 絹田 皆子, 谷口 かおり, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   80回   358 - 358   2021.11

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  • 地域住民男性における大豆イソフラボン代謝産物エクオールと冠動脈石灰化との横断的関連 SESSA研究

    藤吉 朗, 三浦 克之, 門田 文, 有馬 久富, 関川 暁, 近藤 慶子, 門脇 紗也佳, 岡見 雪子, 鈴木 春満, 久松 隆史, 中川 義久, 東山 綾, 岡村 智教, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   53回   248 - 248   2021.10

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  • ガイドラインから発展する筋強直性ジストロフィー診療 筋強直性ジストロフィーの心障害とエビデンスの実装

    伊藤 英樹, 久松 隆史, 田村 拓久, 瀬川 和彦, 高橋 俊明, 高田 博仁, 久留 聡, 和田 千鶴, 鈴木 幹也, 諏訪園 秀吾, 佐々木 真吾, 奥村 謙, 堀江 稔, 高橋 正紀, 松村 剛

    臨床神経学   61 ( Suppl. )   S205 - S205   2021.9

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ

    日本腎臓学会誌   63 ( 4 )   478 - 478   2021.6

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ

    日本腎臓学会誌   63 ( 4 )   478 - 478   2021.6

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  • Association of Accurately Measured Office, Self-measured Home, and Ambulatory Blood Pressure and Their Variability with Intracranial Arterial Stenosis Reviewed

    Hisamatsu T, Ohkubo T, Fujiyoshi A, Torii S, Segawa H, Kond K, Kadota A, Takashima N, Shitara S, Arima H, Nakagawa Y, Watanabe Y, Shiino A, Nozaki K, Ueshima H, Miura K

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2021   2021.5

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  • Factors of Premature Atrial Contractions among General Japanese Men(和訳中)

    Ahmed Sabrina, Miura Katsuyuki, Hisamatsu Takashi, Kadota Aya, Fujiyoshi Akira, Segawa Hiroyoshi, Torii Sayuki, Takashima Naoyuki, Kondo Keiko, Nakagawa Yoshihisa, Ueshima Hirotsugu

    日本循環器学会学術集会抄録集   85回   OE083 - 1   2021.3

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  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連 滋賀動脈硬化疫学研究

    久松 隆史, 大久保 孝義, 藤吉 朗, 鳥居 さゆ希, 瀬川 裕佳, 近藤 慶子, 門田 文, 高嶋 直敬, 設楽 智史, 有馬 久富, 中川 義久, 渡邉 嘉之, 椎野 顯彦, 野崎 和彦, 上島 弘嗣, 三浦 克之

    Journal of Epidemiology   31 ( Suppl. )   89 - 89   2021.1

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  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA

    久米真司, 宮澤伊都子, 門田文, 久松隆史, 近藤慶子, 瀬川裕佳, 鳥居さゆき, 荒木信一, 前川聡, 三浦克之, 上島弘嗣

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率 益田研究

    久松 隆史, 福田 茉莉, 谷口 かおり, 宮川 健, 中畑 典子, 神田 秀幸

    日本公衆衛生学会総会抄録集   79回   339 - 339   2020.10

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  • 日本の中学・高校教員におけるインターネット依存と頸部痛のリスクの関連

    田邉 莉奈, 久松 隆史, 福田 茉莉, 土江 梨奈, 鈴木 雅子, 菅谷 渚, 中村 幸志, 高橋 謙造, 神田 秀幸

    日本アルコール・薬物医学会雑誌   55 ( 5 )   95 - 95   2020.10

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  • 全国高校eスポーツ選手権大会出場校の実態

    神田 秀幸, 田邉 莉奈, 福田 茉莉, 久松 隆史

    日本アルコール・薬物医学会雑誌   55 ( 5 )   90 - 90   2020.10

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  • Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men(和訳中)

    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   84回   OJ25 - 5   2020.7

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  • 日本人男性における冠動脈の石灰化で判断した潜在性アテローム硬化進行と腎機能との関連 SESSA研究(The association between kidney function and subclinical atherosclerosis progression evaluated by coronary artery calcification in Japanese men: SESSA study)

    Ganbaatar Namuun, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Miyazawa Itsuko, Kondo Keiko, Salman Ebtehal, Segawa Hiroyoshi, Torii Sayuki, Kume Shinji, Hisamatsu Takashi, Araki Shinichi, Maegawa Hiroshi, Ueshima Hirotsugu

    日本腎臓学会誌   62 ( 4 )   383 - 383   2020.7

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  • 中年期日本人男性におけるApoAI含有LOX-1リガンドの血中レベルと冠動脈石灰化との関連(Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men)

    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   84回   OJ25 - 5   2020.7

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  • ある閾値を基準にした空腹時血糖の上昇は非糖尿病者における認知機能の低下と関連している 集団ベース研究(Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study)

    Liu Ziyi, Zaid Maryam, Hisamatsu Takashi, Tanaka Sachiko, Fujiyoshi Akira, Miyagawa Naoko, Ito Takahiro, Kadota Aya, Tooyama Ikuo, Miura Katsuyuki, Ueshima Hirotsugu, the SESSA Research Group

    Journal of Epidemiology   30 ( 3-4 )   121 - 127   2020.4

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    <Highlight>●日本人男性集団において認知機能と空腹時血糖の関連を検討した。●認知機能はCASIで評価した。●糖尿病のない男性では血糖値が3.97-6.20mmol/Lの範囲で認知機能が最も高かった。●糖尿病のある男性では、血糖値が高いほど認知機能が低かった。●血糖値と認知機能との関連は糖尿病の有無により異なっていた。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J04763&link_issn=&doc_id=20200423300003&doc_link_id=10.2188%2Fjea.JE20180193&url=https%3A%2F%2Fdoi.org%2F10.2188%2Fjea.JE20180193&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 山陰地方の中学・高校教職員におけるインターネット利用状況の実態

    神田 秀幸, 福田 茉莉, 土江 梨奈, 津村 秀樹, 久松 隆史

    産業衛生学雑誌   62 ( 2 )   108 - 108   2020.3

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  • Relationship of four blood pressure indexes to subclinical cerebrovascular diseases assessed by brain MRI in general Japanese men Reviewed

    Salman E, Kadota A, Hisamatsu T, Segawa H, Torii S, Fujiyoshi A, Kondo K, Arima H, Shiino A, Nozaki K, Miura K, Ueshima H

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2020   2020.3

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  • The relationship between alcohol drinking before sleeping (Ne-Zake) or in the morning (Mukae-Zake) and sleeplessness among farmers Reviewed

    Sato R, Hisamatsu T, Tsumura H, Fukuda M, Esumi Y, Mikajiri K, Tamura S, Kanda H

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2020   2020.3

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  • Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).

    FUSE Keiko, KADOTA Aya, KONDO Keiko, MORINO Katsutaro, FUJIYOSHI Akira, HISAMATSU Takashi, KADOWAKI Sayaka, MIYAZAWA Itsuko, UGI Satoshi, MAEGAWA Hiroshi, MIURA Katsuyuki, UESHIMA Hirotsugu, SESSA Research Group, 布施 恵子, 門田 文, 近藤 慶子, 森野 勝太郎, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣

    Diabetes research and clinical practice   ( 160 )   108002 - 108002   2020.1

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    METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models.

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  • 「健康診査・保健指導における健診項目等の必要性,妥当性の検証,及び地域における健診実施体制の検討のための研究」8.コホート研究での実証:滋賀動脈硬化疫学研究(SESSA)における上下肢血圧比(ABI,Ankle Brachial Index)/脈波伝播速度(PWV,Pulse Wave Velocity)と冠動脈石灰化との関連

    三浦克之, 久松隆史, 藤吉朗, 門田文, 上島弘嗣

    健康診査・保健指導における健診項目等の必要性、妥当性の検証、及び地域における健診実施体制の検討のための研究 令和元年度 総括・分担研究報告書(Web)   2020

  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田茉莉, 中畑典子, 神田秀幸, 神田秀幸

    日本疫学会学術総会講演集(Web)   30th   2020

  • IoTを活用した長期家庭血圧管理研究の実践報告と課題 益田研究(第1報)

    福田 茉莉, 中畑 典子, 宮川 健, 谷口 かおり, 久松 隆史, 神田 秀幸

    日本公衆衛生学会総会抄録集   78回   330 - 330   2019.10

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  • 家庭血圧測定実施者における食習慣と食物摂取状況の変化 益田研究(第2報)

    中畑 典子, 福田 茉莉, 宮川 健, 谷口 かおり, 久松 隆史, 神田 秀幸

    日本公衆衛生学会総会抄録集   78回   330 - 330   2019.10

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連 SESSA

    宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣

    肥満研究   25 ( Suppl. )   250 - 250   2019.10

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  • 勤労者における測定環境室温と家庭血圧値の変動に関する横断研究 益田研究より

    神田 秀幸, 福田 茉莉, 中畑 典子, 宮川 健, 谷口 かおり, 久松 隆史

    日本高血圧学会総会プログラム・抄録集   42回   375 - 375   2019.10

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80

    久松 隆史, 三浦 克之, 大久保 孝義, 門田 文, 近藤 慶子, 喜多 義邦, 早川 岳人, 神田 秀幸, 岡村 智教, 岡山 明, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   42回   302 - 302   2019.10

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  • 現代の我が国の一般地域住民における家庭血圧の現状 Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山 敬, 田原 康玄, 大石 絵美, 坂田 智子, 久松 隆史, 呉代 華容, 樺山 舞, 辰巳 友佳子, 秦 淳, 菊谷 昌浩, 神出 計, 三浦 克之, 二宮 利治, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集   42回   293 - 293   2019.10

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  • 冠動脈石灰化と無症候性脳血管疾患の相関性 コミュニティベース研究(The Association Between Coronary Artery Calcium and The Subclinical Cerebrovascular Disease: A Community Based Study)

    Khan Md Maruf Haque, Fujiyoshi Akira, Miura Katsuyuki, Hisamatsu Takashi, Torii Sayuki, Suzuki Sentaro, Shiino Akihiko, Nozaki Kazuhiko, Ohkubo Takayoshi, Kunimura Ayako, Ueshima Hirotsugu

    日本動脈硬化学会総会プログラム・抄録集   51回   2 - 2   2019.7

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  • 一般日本人女性における受動喫煙状態と血管内皮機能との関連(Association of Passive Smoking Status to Endothelial Vascular Function among General Japanese Women)

    門田 文, 近藤 慶子, 久松 隆史, 宮澤 伊都子, 藤吉 朗, 上島 弘嗣, 三浦 克之

    日本循環器学会学術集会抄録集   83回   PJ041 - 4   2019.3

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  • 現代の我が国の一般地域住民における家庭血圧の現状:Modern Database on Ambulatory and Self-measured home blood pressure(MDAS)

    浅山敬, 田原康玄, 大石絵美, 坂田智子, 久松隆史, 呉代華容, 樺山舞, 辰巳友佳子, 秦淳, 菊谷昌浩, 神出計, 三浦克之, 二宮利治, 大久保孝義

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   42nd   293 - 293   2019

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  • 日本人一般住民男性における腎異所性脂肪の変化と肥満指標との関連 SESSA

    宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣

    肥満研究   40th-37th ( Suppl. )   250 - 250   2019

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  • 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 NIPPON DATA2010実行ワーキンググループ報告

    大久保孝義, 宮本恵宏, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 大澤正樹, 東山綾, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 平成30年度 総括・分担研究報告書(Web)   2019

  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下 SESSA研究

    宮川 尚子, 大久保 孝義, 藤吉 朗, 斎藤 祥乃, 久松 隆史, 門田 文, 関川 暁, 三浦 克之, 上島 弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018.5

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  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤 慶子, 有馬 久富, 岡見 雪子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 森野 勝太郎, 前川 聡, 三浦 克之, 上島 弘嗣, 滋賀動脈硬化疫学研究(SESSA)グループ

    糖尿病   61 ( Suppl.1 )   S - 157   2018.4

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究

    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ

    糖尿病   61 ( Suppl.1 )   S - 293   2018.4

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  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究

    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ

    糖尿病   61 ( Suppl.1 )   S - 293   2018.4

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population Reviewed

    Miyagawa Naoko, Arima Hisatomi, Yoshita Katsushi, Okuda Nagako, Ohkubo Takayoshi, Hisamatsu Takashi, Kondo Keiko, Miura Katsuyuki

    CIRCULATION   137   2018.3

  • Objectively Measured Step Counts Was Independently Associated With Higher Cognition in Apparently Healthy Japanese Men Reviewed

    Shibukawa Takeshi, Fujiyoshi Akira, Miura Katsuyuki, Miyagawa Naoko, Saito Yoshino, Zaid Maryam, Hisamatsu Takashi, Ohkubo Takayoshi, Arima Hisatomi, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   137   2018.3

  • 日本人男性の一般集団における腸内微生物叢と冠動脈石灰化 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Gut Microbiota and Coronary Artery Calcification in a General Population of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))

    有馬 久富, 近藤 慶子, 岡見 雪子, 藤 吉朗, 門田 文, 高嶋 直敬, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ12 - 6   2018.3

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  • 日本人一般集団における血清N-3 polyunsaturated fatty acidと高感度C反応性蛋白の関連性(Association of Serum N-3 Polyunsaturated Fatty Acids and High-sensitivity C-reactive Protein in Japanese General Population)

    中村 翼, 門田 文, 近藤 慶子, 宮川 尚子, 関川 暁, 藤 吉朗, 久松 隆史, 三浦 克之, 上島 弘嗣

    日本循環器学会学術集会抄録集   82回   OJ24 - 7   2018.3

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  • QT延長症候群1型の変異特異的リスク層別化における課題(A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1)

    八木 典章, 伊藤 英樹, 久松 隆史, 大野 聖子, 堀江 稔

    日本循環器学会学術集会抄録集   82回   PJ046 - 3   2018.3

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  • A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1(和訳中)

    八木 典章, 伊藤 英樹, 久松 隆史, 大野 聖子, 堀江 稔

    日本循環器学会学術集会抄録集   82回   PJ046 - 3   2018.3

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  • The Association Between Coronary Artery Calcium And Cerebral Small Vessel Disease: A Population Based Cross Sectional Study Reviewed

    Khan Md, Maruf Haque, Fujiyoshi Akira, Miura Katsuyuki, Hisamatsu Takashi, Torii Sayuki, Suzuki Sentaro, Shiino Akihiko, Nozaki Kazuhiko, Ohkubo Takayoshi, Ueshima Hirotsugu

    STROKE   49   2018.1

  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下 SESSA研究

    宮川 尚子, 大久保 孝義, 藤吉 朗, 斎藤 祥乃, 久松 隆史, 門田 文, 関川 暁, 三浦 克之, 上島 弘嗣

    日本老年医学会雑誌   55 ( Suppl. )   109 - 109   2018

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  • 一般住民男性における無症候性頭蓋内血管性病変と認知機能との関連 滋賀動脈硬化疫学研究SESSA

    伊藤 隆洋, 藤吉 朗, 大久保 孝義, 椎野 顕彦, 野崎 和彦, 宮川 尚子, 鳥居 さゆ希, 久松 隆史, 三浦 克之, 上島 弘嗣

    日本循環器病予防学会誌   53 ( 2 )   189 - 189   2018

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  • 地域住民一般男性における筋肉面積,脂肪筋面積と年齢や体格との関連の検討:SESSA/ERA‐JUMP横断研究

    藤吉朗, 門脇紗也佳, 東宏一郎, 門田文, 門田文, 近藤慶子, 久松隆史, 国村彩子, 関川暁, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   199 - 199   2018

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  • 日本人一般住民男性における腸内細菌と血清LDLコレステロールとの関連:SESSA研究

    岡見雪子, 有馬久富, 近藤慶子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   53 ( 2 )   178 - 178   2018

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 イベント判定委員会報告(ND2010イベント判定委員会)

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 有馬久富, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 門田文, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)   2018

  • CTによる肝脾CT値比と糖尿病発症リスクとの関連:滋賀動脈硬化疫学研究

    布施恵子, 布施恵子, 門田文, 門田文, 近藤慶子, 藤吉朗, 久松隆史, 久松隆史, 門脇紗也佳, 宮澤伊都子, 森野勝太郎, 関根理, 卯木智, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018

  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連

    近藤慶子, 有馬久富, 岡見雪子, 安藤朗, 藤吉朗, 門田文, 門田文, 久松隆史, 宮澤伊都子, 森野勝太郎, 前川聡, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    糖尿病(Web)   61 ( Suppl )   2018

  • 日本人男性の地域在住被験者における喫煙と関連する冠動脈硬化性の高発症率および進行度 The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))

    Pham Tai, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Kadowaki Sayaka, Zaid Maryam, Horie Minoru, Miura Katsuyuki, Ueshima Hirotsugu, for the SESSA Research Group

    日本アルコール・薬物医学会雑誌   52 ( 4 )   239 - 239   2017.8

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連 滋賀動脈硬化疫学研究SESSA

    久松 隆史, 三浦 克之, 有馬 久富, 門田 文, 門脇 紗也佳, 鳥居 さゆ希, 鈴木 仙太朗, 宮川 尚子, 佐藤 敦, 藤吉 朗, 大久保 孝義, アボット・ロバート, 関川 暁, 堀江 稔, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集   49回   112 - 112   2017.6

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  • Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study Reviewed

    Fujiyoshi Akira, Ohkubo Takayoshi, Miura Katsuyuki, Shiino Akihiko, Miyagawa Naoko, Takashima Naoyuki, Saitoh Yoshino, Torii Sayuki, Kadota Aya, Kadowaki Sayaka, Hisamatsu Takashi, Miyazawa Itsuko, Tooyama Ikuo, Ueshima Hirotsugu

    CIRCULATION   135   2017.3

  • Risk Factors for the Progression and Incidence of Aortic Calcification in an International Multi-ethnic Cohort of Men Aged 40-49 Years: ERA JUMP Study

    Siyi Shangguan, Jingchuan Guo, Hemant Mahajan, Kamal Masaki, Bradly J. Willcox, Katsuyuki Miura, Hirotsugu Ueshima, Akira Fujiyoshi, Takashi Hisamatsu, Lewis H. Kuller, Emma J. Barinas-Mitchell, Daniel Edmundowicz, Akira Sekikawa

    CIRCULATION   135   2017.3

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  • Prevalence Of Intracranial Artery Stenosis and the Association With Conventional Risk Factors of Cardiovascular Diseases in a General Population of Japanese: SESSA Study

    Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Torii Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION   135   2017.3

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  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連 地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    久松 隆史, 三浦 克之, 渋川 武志, 藤吉 朗, 有馬 久富, 門田 文, 宮川 尚子, 鳥居 さゆ希, 近藤 慶子, 宮澤 伊都子, 鈴木 仙太朗, 佐藤 敦, 山添 正博, 柳田 昌彦, 前川 聡, 上島 弘嗣

    日本循環器病予防学会誌   52 ( 1 )   20 - 28   2017.3

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    【背景】客観的に評価された身体活動量がメタボリックシンドローム(MetS)発症リスクと関連するかどうか検討した研究はほとんどない。【目的】日本人一般住民男性において、歩数計を用いて評価された歩数値とMetS新規発症との関連を縦断的に検討すること。【方法】滋賀県草津市住民から無作為抽出された40-79歳男性のうちMetSを有さない525名(平均年齢64.1±9.6歳)を対象とし、5年間の前向きコホート研究(基礎調査2006-8年)を実施した。歩数は基礎調査時に土・日曜日を含む7日間連続で歩数計を用いて測定し1日平均値を求めた。MetS発症の診断は日本基準を用いて評価した。ロジスティック回帰を用いてMetS新規発症に対する歩数値に関する多変量調整相対リスク(RR)および95%信頼区間(CI)を算出した。【結果】平均追跡期間4.8±1.3年を経て、MetS新規発症者は77名(14.7%)であった。Body mass indexを含む交絡因子を調整後も歩数値とMetS発症との間に負の関連を認めた。この関連はMetS各構成要素でさらに調整しても変わらなかった(最低三分位群[5,792歩未満]と比較して、最高三分位群[10,033歩以上]のMetS発症に対するRR(95%CI)は0.34[0.17-0.72])。また、MetS発症に対する1日平均1,000歩増加あたりのRR(95%CI)は、0.87(0.78-0.96)であった。65歳未満・以上、MetS各構成要素の有無で層別に解析したが同様の傾向を認めた(全異質性P値>0.3)。【結語】MetSの好発集団とされる一般中高年男性において、客観的に評価された歩数値はMetS発症と有意な負の関連を示した。また、1日平均歩数値1,000歩増加あたりMetS発症リスクが13%低下した。本成果は健康日本21(第二次)の歩数目標値や身体活動基準2013を支持する結果である。(著者抄録)

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  • 日常的歩行運動レベルが左心房拡大,心房細動発症に与える影響―地域住民7年追跡研究―

    山添正博, 久松隆史, 大野聖子, 有馬久富, 三浦克之, 上島弘嗣

    若手研究者のための健康科学研究助成成果報告書   ( 32 )   108 - 113   2017

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連 滋賀潜在性動脈硬化研究(SESSA)

    宮澤 伊都子, 大久保 孝義, 藤吉 朗, 久松 隆史, 門田 文, 村上 陽子, 永谷 幸裕, 門脇 紗也佳, 村田 喜代史, 前川 聡, 三浦 克之, 上島 弘嗣

    日本循環器病予防学会誌   52 ( 2 )   201 - 201   2017

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討 パイロット研究

    宮川 尚子, 有馬 久富, 由田 克士, 奥田 奈賀子, 大久保 孝義, 久松 隆史, 近藤 慶子, 三浦 克之

    日本循環器病予防学会誌   52 ( 2 )   171 - 171   2017

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連:滋賀動脈硬化疫学研究SESSA

    炭昌樹, 久松隆史, 久松隆史, 藤吉朗, 門田文, 門田文, 宮川尚子, 近藤慶子, 門脇紗也佳, 鈴木仙太朗, 鳥居さゆ希, 鳥居さゆ希, MARYAM Zaid, 佐藤敦, 有馬久富, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本循環器病予防学会誌   52 ( 2 )   183 - 183   2017

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 NIPPON DATA2010イベント判定委員会

    大久保孝義, 門田文, 清原裕, 寳澤篤, 二宮利治, 中村幸志, 高嶋直敬, 宮本恵宏, 大澤正樹, 東山綾, 長澤晋哉, 久松隆史, 鳥居さゆ希, 八谷寛, 大西浩文, 櫻井勝, 浅山敬, 平田匠, 宮澤伊都子

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)   21‐24 (WEB ONLY)   2017

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  • 一般地域男性住民における高い睡眠呼吸障害有所見率とその要因―SESSA研究―

    高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 鳥居さゆ希, 佐藤敦, 宮川尚子, 門田文, 門田文, 有馬久富, 有馬久富, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本疫学会学術総会講演集(Web)   27th   150 (WEB ONLY)   2017

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 宮川尚子, 佐藤敦, 藤吉朗, 大久保孝義, アボット ロバート, 関川暁, 堀江稔, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   112 (WEB ONLY) - 112   2017

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較,及びその差に影響を及ぼす要因の検討:滋賀動脈硬化疫学研究(SESSA)

    門脇紗也佳, 寳澤篤, 藤吉朗, 久松隆史, 佐藤敦, 田中佐智子, 岡村智教, 大久保孝義, 三浦克之, 三浦克之, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   40th   408 - 408   2017

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  • 非肥満者に対する保健指導方法の開発に関する研究 非肥満者を含む集団への生活習慣に関する介入研究の文献レビュー

    宮本恵宏, 岡村智教, 岡山明, 磯博康, 三浦克之, 小川佳宏, 荒木田美香子, 東山綾, 竹上未紗, 渡邉至, 小久保喜弘, 西村邦宏, 中村文明, 渡邉琢也, 辰巳友佳子, 杉山大典, 桑原和代, 原田成, 竹内文乃, 栗原綾子, 深井航太, 飯田美穂, 平田あや, 深井航太, 飯田美穂, 平田あや, 平田匠, 崔仁哲, 宮澤伊都子, 久松隆史, 鳥居さゆ希, 山添正博, 坊内良太郎, 松田有子

    非肥満者に対する保健指導方法の開発に関する研究 平成28年度 総括・分担研究報告書(宮本恵宏)(Web)   2017

  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    近藤慶子, 有馬久富, 久松隆史, 藤吉朗, 門田文, 関川暁, 鳥居さゆ希, 鈴木仙太朗, 椎野顯彦, 野崎和彦, 宮川尚子, 前川聡, 村田喜代史, 三浦克之, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   49th   195 - 195   2017

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  • Comparison of anthropometric measures of obesity in the association with coronary artery calcification in the general Japanese population

    Y. Sugimoto, T. Hisamatsu, K. Miura, S. Kadowaki, A. Kadota, M. Zaid, S. Torii, N. Miyagawa, A. Satoh, Y. Saitoh, M. Yamazoe, H. Arima, A. Fujiyoshi, A. Sekikawa, H. Ueshima

    EUROPEAN HEART JOURNAL   37   546 - 546   2016.8

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  • Is Home Blood Pressure More Strongly Associated with Coronary Artery Calcification Than Clinic Blood Pressure Measured Under an Appropriate Condition? Reviewed

    Satoh Atsushi, Arima Hisatomi, Hozawa Atsushi, Hisamatsu Takashi, Kadowaki Sayaka, Kadota Aya, Fujiyoshi Akira, Miyagawa Naoko, Zaid Maryam, Torii Sayuki, Ohkubo Takayoshi, Okamura Tomonori, Sekikawa Akira, Miura Katsuyuki, Ueshima Hirotsugu

    CIRCULATION   133   2016.3

  • Significant Inverse Association of Blood Levels of Marine Omega-3 Fatty Acids with Coronary Artery Calcification in Men in Japan

    Akira Sekikawa, Marnie Bertolet, Abhishek Vishnu, Vasudha Ahuja, Rhobert W. Evans, Lewis H. Kuller, Akira Fujiyoshi, Takashi Hisamatsu, Takashi Kadowaki, Aya Kadota, Sayaka Kadowaki, Hisatomi Arima, Katsuyuki Miura, Hirotsugu Ueshima

    CIRCULATION   133   2016.3

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  • Re-evaluation of Prognostic Values of Clockwise and Counterclockwise Rotation for Total and Cardiovascular Mortality in a Different Cohort (20 Year Follow-up of NIPPON DATA90)

    Yasuyuki Nakamura, Tomonori Okamura, Akira Fujiyoshi, Aya Kadota, Takashi Hisamatsu, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima

    CIRCULATION   133   2016.3

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  • Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome in a General Population

    Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Akira Fujiyoshi, Robert Abbott, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Hone, Hirotsugu Ueshima

    CIRCULATION   133   2016.3

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  • Significant Positive Association of Progression in Arterial Stiffness with Accelerated Increase in Aortic Calcification Among Multi-ethnic Middle-aged Men (ERA JUMP Study)

    Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Vishnu Abhishek, Emma Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Bradley Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

    CIRCULATION   133   2016.3

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  • 一般集団においてinsulin抵抗性はメタボリックシンドロームよりも冠動脈石灰化の有病率および進行に関連する(Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification beyond Metabolic Syndrome in a General Population)

    Yamazoe Masahiro, Hisamatsu Takashi, Miura Katsuyuki, Kadowaki Sayaka, Zaid Maryam, Fujiyoshi Akira, Kadowaki Takashi, Abbott Robert, Arima Hisatomi, Sekikawa Akira, Maegawa Hiroshi, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   80 ( Suppl.I )   2036 - 2036   2016.3

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  • 日本人男性における心臓周囲脂肪量の縦断的変化の予測因子とは 滋賀動脈硬化疫学研究(SESSA)(Which Factors Predict Longitudinal Change of Pericardial Fat Volume in Japanese Men? The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA))

    Miyazawa Itsuko, Ohkubo Takayoshi, Kadowaki Sayaka, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Arima Hisatomi, Miura Katsuyuki, Maegawa Hiroshi, Ueshima Hirotsugu

    Circulation Journal   80 ( Suppl.I )   823 - 823   2016.3

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   117   2016.1

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  • 睡眠時間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究(SESSA)

    鈴木仙太朗, 有馬久富, 有馬久富, 宮崎総一郎, 藤吉朗, 門田文, 門田文, 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 門脇紗也佳, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   121   2016.1

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  • 客観的に評価された歩数値とメタボリック症候群発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    久松隆史, 久松隆史, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 上島弘嗣

    日本循環器病予防学会誌   51 ( 2 )   120 - 120   2016

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  • 日本人一般住民における肥満指標と冠動脈石灰化との関連の比較検討

    杉本裕子, 久松隆史, 三浦克之, 門脇紗也佳, 門田文, MARYAM Zaid, 鳥居さゆ希, 鳥居さゆ希, 宮川尚子, 佐藤敦, 斎藤祥乃, 山添正博, 有馬久富, 藤吉朗, 関川暁, 上島弘嗣

    日本循環器学会近畿地方会(Web)   121st   KINKI121,D07 (WEB ONLY)   2016

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討 パイロット研究

    宮川 尚子, 有馬 久富, 由田 克士, 奥田 奈賀子, 大久保 孝義, 久松 隆史, 近藤 慶子, 岡見 雪子, 三浦 克之

    日本循環器病予防学会誌   51 ( 2 )   114 - 114   2016

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  • 飲酒はLDLコレステロール濃度とLDL粒子数を減らす~メンデルランダム化解析

    田原康玄, 上島弘嗣, 高嶋直敬, 久松隆史, 藤吉朗, ZAID Maryam, 炭昌樹, 小原克彦, 三木哲郎, 三浦克之

    日本循環器病予防学会誌   51 ( 2 )   139 - 139   2016

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  • 喫煙習慣,喫煙指数,禁煙期間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究SESSA

    久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   2016

  • 睡眠時間と潜在性動脈硬化との関連:滋賀動脈硬化疫学研究(SESSA)

    鈴木仙太朗, 有馬久富, 有馬久富, 宮崎総一郎, 藤吉朗, 門田文, 門田文, 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 門脇紗也佳, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    Journal of Epidemiology (Web)   26 ( Supplement 1 )   2016

  • THE ASSOCIATION OF BRACHIAL-ANKLE PULSE WAVE VELOCITY AND ESTIMATED GLOMERULAR FILTRATION RATE WITH ALBUMINURIA AMONG GENERAL JAPANESE

    A. Kadota, K. Miura, T. Ohkubo, T. Hisamatsu, A. Fujiyoshi, N. Takashima, T. Okamura, H. Ueshima

    ATHEROSCLEROSIS   241 ( 1 )   E130 - E130   2015.7

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  • THE ASSOCIATION BETWEEN VASCULAR RISK FACTORS AND OVER ACTIVE BLADDER

    Teruhiko Tsuru, Isao Araki, Sayaka Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Akihiro Kawauchi, Katsuyuki Miura, Hirotsugu Ueshima

    JOURNAL OF UROLOGY   193 ( 4 )   E302 - E303   2015.4

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  • 滋賀医科大学アジア疫学研究センターの取り組み NCD克服のための疫学研究・教育拠点を目指して

    三浦 克之, 堀江 稔, 野崎 和彦, 久松 隆史, Abbott Robert D.

    滋賀医科大学看護学ジャーナル   13 ( 1 )   8 - 14   2015.3

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    滋賀医科大学では2013年10月に、新しい総合研究棟(疫学研究拠点)としてアジア疫学研究センターが新築、開所した。本センターは、本学のこれまでの生活習慣病疫学研究の実績を生かし、良好な研究環境による国際共同疫学研究の実施、大規模データベースの管理とバイオバンクによる生体試料保存を行うことを可能にするものである。また、これと時期を同じくして、文部科学省の平成25年度博士課程教育リーディングプログラムが採択され、アジア疫学研究センターを教育基盤とした博士課程教育リーディングプログラム「アジア非感染性疾患(NCD)超克プロジェクト」が開始された。本プログラムでは国内外の産学官の広い分野においてアジア太平洋州のトップリーダーとして活躍するNCD対策の専門家を育成する。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J04402&link_issn=&doc_id=20150416340002&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10422%2F9294&url=http%3A%2F%2Fhdl.handle.net%2F10422%2F9294&type=%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%81F%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%8B%40%8A%D6%83%8A%83%7C%83W%83g%83%8A%82%D1%82%ED%8C%C9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80165_3.gif

  • 一般日本人集団における主要および軽微なECG異常の無症候性アテローム硬化との関連性 SESSA(Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA)

    Hisamatsu Takashi, Miura Katsuyuki, Fujiyoshi Akira, Kadowaki Sayaka, Zaid Maryam, Torii Sayuki, Kadota Aya, Nakamura Yasuyuki, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   79 ( Suppl.I )   2059 - 2059   2015.3

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  • 日本人男性におけるhigh-density lipoprotein粒子濃度と頸動脈の無症候性アテローム性動脈硬化症との関連性(The Association of High-density Lipoprotein Particle Concentration with Subclinical Atherosclerosis of the Carotid Arteries in Japanese Men)

    Zaid Maryam, Fujiyoshi Akira, Miura Katsuyuki, Abbott Robert D., Okamura Tomonori, Takashima Naoyuki, Torii Sayuki, Saito Yoshino, Hisamatsu Takashi, Miyagawa Naoko, Ohkubo Takayoshi, Kadota Aya, Sekikawa Akira, Maegawa Hiroshi, Nakamura Yasuyuki, Mitsunami Kenichi, Ueshima Hirotsugu

    Circulation Journal   79 ( Suppl.I )   634 - 634   2015.3

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  • 家庭血圧は理想的環境下で測定した診察室血圧より冠動脈石灰化と強く関連するか? Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    佐藤 敦, 有馬 久富, 寳澤 篤, 久松 隆史, 門田 文, 藤吉 朗, 宮川 尚子, Zaid Maryam, 鳥居 さゆ希, 大久保 孝義, 岡村 智教, 関川 暁, 三浦 克之, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   38th   397 - 397   2015

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 水銀血圧計使用中止に伴う代替測定法の検討

    三浦克之, 三浦克之, 久松隆史, 久松隆史, 大久保孝義, 上島弘嗣, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成26年度 総括・分担研究報告書   2015

  • non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 一般住民におけるnon-HDL-Cの長期冠動脈疾患予測能および,潜在性冠動脈硬化との関連の検討

    藤吉朗, 久松隆史, 伊藤隆洋

    non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 平成26年度 総括・分担研究報告書   2015

  • non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 Non-HDLコレステロールの臨床的意義に関する文献レビュー

    岡村智教, 木山昌彦, 宮本恵宏, 藤吉朗, 杉山大典, 桑原和代, 深井航太, 加藤寿寿華, 飯田美穂, 石川碧, 村木功, 羽山実奈, 梶浦貢, 陣内裕成, 丸山広達, 竹上未紗, 伊藤隆洋, ZAID Maryam, HO Nguyen Nhu, 久松隆史

    non-HDL等血中脂質評価指針及び脂質標準化システムの構築と基盤整備に関する研究 平成26年度 総括・分担研究報告書   2015

  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 身体状況調査会場に来場した対象者における血圧測定精度の検討

    三浦克之, 三浦克之, 久松隆史, 久松隆史, 上島弘嗣, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成26年度 総括・分担研究報告書   2015

  • Modified LDL (serum level of LOX-1 ligand containing ApoB) was associated with increased carotid intima-media thickness in Japanese community dwelling men especially with hypercholesterolemia

    T. Okamura, T. Sawamura, T. Hisamatsu, A. Fujiyoshi, A. Kadota, N. Miyamatsu, K. Miura, H. Ueshima

    INTERNATIONAL JOURNAL OF STROKE   9   281 - 282   2014.10

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  • Transferrin saturation and risk for cardiovascular mortality: a 20-year follow-up

    T. Hisamatsu, K. Miura, A. Fujiyoshi, T. Ohkubo, N. Miyagawa, N. Okuda, T. Hayakawa, A. Okayama, T. Okamura, H. Ueshima

    EUROPEAN HEART JOURNAL   35   52 - 52   2014.9

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  • J波症候群と関連する電気的障害 日本人集団における早期再分極 日本における循環器疾患基礎調査(NIPPON DATA)からの新たな知見(J-wave Syndrome and Related Electrical Disorders Early Repolarization in Japanese General Population: New Findings from the National Surveys of Circulatory Disorders of Japan (NIPPON DATA))

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu

    Circulation Journal   78 ( Suppl.I )   115 - 115   2014.3

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  • Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014

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  • Relationship Of Plasma Asymmetrical Dimethylarginine To Carotid Intima-media Thickness In General Japanese Population: The ERA-JUMP And The SESSA.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014

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  • Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014

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  • Brachial-ankle Pulse Wave Velocity is Independently Associated with Presence of Coronary Calcification among 1131 Healthy Middle-aged Men. The ERA JUMP Study.

    EPI|NPAM2014 Abstracts   - ( - )   --サンフランシスコ   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 1.NIPPON DATA80 リスクチャートを用いた冠動脈死亡絶対危険度,動脈硬化学会脂質管理カテゴリーと頸部動脈硬化所見との関連の検討

    KADOTA AYA, MIURA KATSUYUKI, OKAMURA TOMONORI, FUJIYOSHI AKIRA, OKUBO TAKAYOSHI, KADOWAKI TAKASHI, TAKASHIMA NAOTAKA, HISAMATSU TAKASHI, NAKAMURA YASUYUKI, KASAGI FUMIYOSHI, MAEGAWA HIROSHI, KASHIWAGI ATSUNORI, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   133 - 134   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 10.日本人一般男性において長鎖n3脂肪酸の高摂取は心疾患死亡リスクにおける安静的心拍数上昇の影響を減弱させる

    HISAMATSU TAKASHI, MIURA KATSUYUKI, OKUBO TAKAYOSHI, YAMAMOTO TAKASHI, FUJIYOSHI AKIRA, MIYAGAWA NAOKO, KADOTA AYA, TAKASHIMA NAOTAKA, OKUDA NAKAKO, YOSHITA KATSUSHI, KITA YOSHIKUNI, MURAKAMI YOSHITAKA, NAKAMURA YASUYUKI, HORIE MINORU, OKAMURA TOMONORI, OKAYAMA AKIRA, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   218 - 219   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 24.日本人一般住宅における早期再分極:日本循環器疾患基礎調査からの新たな知見

    HISAMATSU TAKASHI, MIURA KATSUYUKI, OKUBO TAKAYOSHI, OKAMURA TOMONORI, OKAYAMA AKIRA, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   265 - 266   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 7.日本人一般男性における心疾患死亡リスクに対する早期再分極とn‐3不飽和脂肪酸摂取量との交互作用の検討

    HISAMATSU TAKASHI, MIURA KATSUMI, OKUBO TAKAYOSHI, YAMAMOTO TAKASHI, FUJIYOSHI AKIRA, MIYAGAWA NAOKO, KADOTA AYA, TAKASHIMA NAOTAKA, OKUDA NAKAKO, MATSUMURA YASUHIRO, YOSHITA KATSUSHI, KITA YOSHIKUNI, MURAKAMI YOSHITAKA, NAKAMURA YASUYUKI, HORIE MINORU, OKAMURA TOMONORI, OKAYAMA AKIRA, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   186 - 187   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 3.日本人の血糖値,糖尿病有病率・治療率の30年間の推移の検討

    ONISHI HIROFUMI, OKUBO TAKAYOSHI, KADOTA AYA, FUJIYOSHI AKIRA, FURUYA YOSHIMI, TANAKA HIDEO, HIRATA TAKUMI, HISAMATSU TAKASHI, SATO ATSUSHI, SAKURAI MASARU, SAITO SHIGEYUKI, SAKATA KIYOMI, UESHIMA HIROTSUGU, MIURA KATSUYUKI

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   116 - 126   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 9.日本人における長鎖n‐3不飽和脂肪酸摂取と循環器疾患死亡リスクの関連

    MIYAGAWA NAOKO, MIURA KATSUYUKI, OKUDA NAKAKO, KADOWAKI TAKASHI, TAKASHIMA NAOTAKA, NAGASAWA SHIN'YA, NAKAMURA YASUYUKI, MATSUMURA YASUHIRO, HOZAWA ATSUSHI, FUJIYOSHI AKIRA, HISAMATSU TAKASHI, YOSHITA KATSUSHI, SEKIKAWA AKIRA, OKUBO TAKAYOSHI, ABBOTT ROBERT D, OKAMURA TOMONORI, OKAYAMA AKIRA, UESHIMA HIROTSUGU

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   210 - 211   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 3.NIPPON DATA80/90/2010における心電図の解析について

    OKAMURA TOMONORI, NAKAMURA YOSHIKAZU, SAITO SHIGEYUKI, NAKAMURA YASUYUKI, WATANABE MAKOTO, NAKAMURA KOUSHI, KOSAKA SHUN, HIGASHIYAMA AYA, TORII SAYUKI, SAWANO MITSUAKI, SUGIYAMA DAISUKE, HISAMATSU TAKASHI, NAKAMURA MIEKO, TAHARA AKIKO, MIURA KATSUYUKI, TOYOSHIMA HIDEAKI, CHISHAKI AKIKO

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   25 - 32   2014

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 血圧測定における自動血圧計の導入に関する課題および提言

    三浦克之, 三浦克之, 久松隆史, 久松隆史, 上島弘嗣, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成25年度 総括・分担研究報告書   2014

  • 動脈硬化指標と過活動膀胱との関連についての検討:滋賀動脈硬化疫学研究(SESSA)より

    水流輝彦, 荒木勇雄, 門脇沙也佳, 久松隆史, 久松隆史, 藤吉朗, 河内明宏, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本排尿機能学会誌   25 ( 1 )   153 - 153   2014

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  • 高齢男性における過活動膀胱と動脈硬化指標との関係:滋賀動脈硬化疫学研究から

    水流輝彦, 荒木勇雄, 河内明宏, 門脇紗也佳, 久松隆史, 藤吉朗, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣

    日本泌尿器科学会総会プログラム抄録集(CD-ROM)   102nd   423 - 423   2014

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  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 4.高血圧の有無による心電図所見の検討

    鳥居さゆ希, 岡村智教, 香坂俊, 澤野充明, 久松隆史, 東山綾, 渡邉至, 中村保幸

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成25年度 総括・分担研究報告書   2014

  • The Relationship of Serum Marine-Derived N-3 Fatty Acids and Carotid Intima-Media Thickness among General Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Reviewed

    Kadota Aya, Sekikawa Akira, Miura Katsuyuki, Okamura Tomonori, Fujiyoshi Akira, Kadowaki Takashi, Barinas-Mitchell Emma, Evans Rhobert W, Ohkubo Takayoshi, Hisamatsu Takashi, Miyagawa Naoko, Nakamura Yasuyuki, Maegawa Hiroshi, Kashiwagi Atsunori, Ueshima Hirotsugu

    CIRCULATION   127 ( 12 )   2013.3

  • High-density Lipoprotein Particle Concentration is Independently Associated with Carotid Intima-media Thickness in Japanese Men Reviewed

    Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Tomonori Okamura, Takashima Naoyuki, Sayuki Torii, Yoshino Saito, Hisamatsu Takashi, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima

    CIRCULATION   127 ( 12 )   2013.3

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  • 長鎖n-3系脂肪酸の食事による高摂取は心血管疾患死亡リスクに関係する安静時心拍数増加の影響を軽減させる(Higher Dietary Long-chain n-3 Fatty Acids Attenuated the Effect of Higher Resting Heart Rate on the Risk of Cardiovascular Mortality)

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Yamamoto Takashi, Miyagawa Naoko, Fujiyoshi Akira, Kadota Aya, Takashima Naoyuki, Okuda Nagako, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Okayama Akira, Ueshima Hirotsugu

    Circulation Journal   77 ( Suppl.I )   259 - 260   2013.3

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  • 一般日本人集団において非HDLコレステロールは冠動脈石灰化と強く関連する SESSA(Non-HDL Cholesterol is Strongly Associated with Coronary Artery Calcification in a General Japanese Population: SESSA)

    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Fujiyoshi Akira, Kadota Aya, Kadowaki Sayaka, Yamamoto Takashi, Miyagawa Naoko, Torii Sayuki, Saitoh Yoshino, Takashima Naoyuki, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Ueshima Hirotsugu

    Circulation Journal   77 ( Suppl.I )   123 - 123   2013.3

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  • 日本人男性における心臓周囲脂肪と肥満指標との関連:滋賀潜在性動脈硬化研究(SESSA)

    宮澤伊都子, 大久保孝義, 三浦克之, 藤吉朗, 門脇紗也佳, 宮川尚子, 高嶋直敬, 斉藤祥乃, 鳥居さゆ希, 久松隆史, 門田文, 前川聡, 上島弘嗣

    日本循環器病予防学会誌   48 ( 2 )   144 - 144   2013

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  • 高齢男性における慢性腎臓病と認知機能との関連:滋賀動脈硬化疫学研究

    藤吉朗, 大久保孝義, 三浦克之, 椎野顕彦, 宮川尚子, 高嶋直敬, 齋藤祥乃, 鳥居さゆ希, 門田文, 門脇紗也佳, 久松隆史, 宮澤伊都子, 上島弘嗣

    日本循環器病予防学会誌   48 ( 2 )   147 - 147   2013

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  • 日本人一般男性集団における脈波伝播速度と頸動脈内膜中膜肥厚および頸動脈プラークとの関連:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    鳥居さゆ希, 藤吉朗, 門田文, 高嶋直敬, 門脇紗也佳, 久松隆史, 斎藤祥乃, 宮川尚子, MARYAM Zaid, 大久保孝義, 三浦克之, 上島弘嗣

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   45th   317 - 317   2013

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  • 地域住民男性における生涯喫煙量と内臓脂肪との関連 SESSA研究

    藤吉 朗, 三浦 克之, 門脇 紗也佳, 門田 文, 大久保 孝義, 宮川 尚子, 久松 隆史, 齋藤 祥乃, 鳥居 さゆ希, 宮澤 伊都子, 三ツ浪 健一, 前川 聡, 村田 喜代史, 上島 弘嗣

    肥満研究   19 ( Supplement )   196 - 196   2013

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  • Lipoprotein Particle Profiles by Nuclear Magnetic Resonance, Standard Lipids and Coronary Artery Calcification in a Japanese General Population: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    第45回日本動脈硬化学会抄録   2013

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  • 早期再分極(early repolarization)症候群の病態と遺伝基盤,長期予後に関する研究 早期再分極と冠動脈疾患死亡との関連についての研究:NIPPON DATA90による15年追跡結果

    堀江稔, 久松隆史, 山本孝, 大久保孝義, 三浦克之, 藤吉朗, 高嶋直敬, 喜多義邦, 村上義孝, 岡村智教, 上島弘嗣

    早期再分極(early repolarization)症候群の病態と遺伝基盤、長期予後に関する研究 平成24年度 総括・分担研究報告書   11 - 26   2013

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  • 日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 国民健康・栄養調査(2008-2010年)における血圧測定精度の検討:INTERMAP日本研究との比較

    三浦克之, 久松隆史, 久松隆史, 上島弘嗣

    日本人の健康・栄養状態のモニタリングを目的とした国民健康・栄養調査のあり方に関する研究 平成24年度 総括・分担研究報告書   2013

  • ALCOHOL CONSUMPTION AND INFLAMMATION MARKERS: SHIGA EPIDEMIOLOGICAL STUDY OF SUBCLINICAL ATHEROSCLEROSIS (SESSA)

    S. Torii, K. Miura, A. Fujiyoshi, T. Ohkubo, A. Kadota, T. Hisamatsu, Y. Saitoh, S. Kadowaki, S. Suzuki, N. Miyagawa, H. Ueshima

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   36   109A - 109A   2012.9

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  • 循環器疾患による早世(65歳未満死亡)の要因の検討 NIPPON DATA80

    高嶋 直敬, 三浦 克之, 大久保 孝義, 村上 義孝, 喜多 義邦, 門田 文, 藤吉 朗, 宮川 尚子, 久松 隆史, 鳥居 さゆ希, 斎藤 祥乃, 早川 岳人, 岡村 智教, 岡山 明, 上島 弘嗣

    日本循環器病予防学会誌   47 ( 2 )   113 - 113   2012

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  • 日本人一般男性における心疾患死亡リスクに対する早期再分極とn-3不飽和脂肪酸摂取量との交互作用の検討 NIPPON DATA80

    久松 隆史, 三浦 克之, 大久保 孝義, 宮川 尚子, 藤吉 朗, 高嶋 直敬, 門田 文, 奥田 奈賀子, 村上 義孝, 堀江 稔, 岡村 智教, 岡山 明, 上島 弘嗣

    日本心臓病学会誌   7 ( Supplement 1 )   285 - 285   2012

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  • 日本人一般男性集団における脈波伝播速度と冠動脈石灰化との関連:Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)

    鳥居さゆ希, 大久保孝義, 藤吉朗, 門田文, 高嶋直敬, 門脇紗也佳, 久松隆史, 齋藤祥乃, 宮川尚子, 村上義孝, 三浦克之, 上島弘嗣

    日本高血圧学会総会プログラム・抄録集   35th   401 - 401   2012

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  • Effect modification of dietary n-3 fatty acids on cardiovascular mortality risk by resting heart rate general population:NIPPON DATA80

    T Hisamatsu, K Miura, T Ohkubo, N Okuda, Y Murakami, N Miyagawa, M Horie, T Okamura, A Okayama, H Ueshima

    ESC2012   - ( - )   ---   2012

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  • Interaction of Dietary n-3 Fatty Acids on Cardiac Risk by J-point elevation in japanese Men: NIPPON DATA.

    Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Akira Fujiyoshi, Naoyuki Takashima, Aya Kadota, Nagako Okuda, Akira Okayama, Hirotsugu Ueshima

    AHA EPI | NPAM 2012(サンディエゴ)   2012

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  • 症例:ブラッドアクセス側腕頭静脈狭窄に対してPTAを施行し,シャント高血圧が改善した維持血液透析患者の1例

    望月裕司, 田中雅博, 久松隆史, 大平直人, 筒井崇

    奈良県医師会透析部会誌   17 ( 1 )   80 - 80   2012

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  • データブック アテローム血栓症の大規模臨床試験 PART 3 6.包括的管理・治療 REACH 5.アテローム血栓症を有する外来患者における1年追跡による循環器イベント発生率の検討(REACH Registry)

    久松隆史, 三浦克之, 堀江稔

    血栓と循環   19 ( 3 )   2011

  • ループス腎炎に対する免疫抑制剤加療中に出現した尿蛋白量の減少にACE阻害薬(イミダプリル)が奏効した一例

    下垣 保恵, 筒井 崇, 大平 直人, 久松 隆史, 田中 雅博, 望月 裕司, 豊田 嘉清, 中井 直治, 竹内 孝男, 郡山 健治, 河野 厚

    臨床リウマチ   22 ( 4 )   389 - 393   2010.12

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    50歳女性。患者はループス腎炎の寛解期に蛋白尿が出現した。蛋白尿はステロイドにタクロリムスとARB併用することで低下したが、正常範囲には至らず、ARBをACE-Iに変更したところ、正常値範囲に至った。

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J02269&link_issn=&doc_id=20110113250004&doc_link_id=10.14961%2Fcra.22.389&url=https%3A%2F%2Fdoi.org%2F10.14961%2Fcra.22.389&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 今なぜ,トータル血管マネージメントが必要なのか 血管マネージメント 2)日本人の脳卒中,心筋梗塞,腎臓病に対するリスク因子の寄与度の違い:わが国の疫学研究から

    久松隆史, 久松隆史, 大久保孝義, 堀江稔, 三浦克之

    Mebio   27 ( 10 )   2010

  • 血液透析患者に発症した深部静脈血栓症に対して下大静脈フィルター留置後血栓溶解療法を施行した1例

    望月裕司, 相原衣江, 田中雅博, 久松隆史, 吉野知秀, 筒井崇

    奈良県医師会透析部会誌   15 ( 1 )   128 - 129   2010

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  • 血液透析患者に発症した深部静脈血栓症に対して下大静脈フィルター留置後血栓溶解療法を施行した1例

    望月裕司, 相原衣江, 田中雅博, 久松隆史, 吉野知秀, 筒井崇, 近藤雅彦, 栗原陽次郎

    日本透析医学会雑誌   42 ( Supplement 1 )   699 - 699   2009

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  • 上腕アプローチよりF-Pバイパスに対してPTAを施行した1例

    上野義記, 道智賢市, 久松隆史, 大林靖典, 北川成子, 小野進

    滋賀医学   30   112 - 112   2008

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  • 経皮的血管縫合デバイス(パークローズAT)使用後に急性大腿動脈閉塞症を合併した1症例

    久松隆史, 上野義記, 川口民郎, 大林靖典, 北川成子, 小野進

    Circulation Journal   71 ( Supplement 2 )   923 - 923   2007

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  • 敗血症性肺塞栓にて発症した心室中隔欠損症に伴う感染性心内膜炎の一例

    吉野 知秀, 久松 隆史, 坪内 直也, 松本 鉄也, 堀江 稔, 浅井 徹, 白石 昭一郎

    Circulation Journal   69 ( Suppl.III )   981 - 981   2005.10

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  • 冠動脈造影にて有意狭窄を認めなかった労作性狭心症の1症例

    久松 隆史, 中江 一郎, 高島 弘行, 松尾 信郎, 松本 鉄也, 堀江 稔

    Circulation Journal   69 ( Suppl.II )   874 - 874   2005.4

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Presentations

  • Association of Accurately Measured Office, Self-measured Home, and Ambulatory Blood Pressure and Their Variability with Intracranial Arterial Stenosis

    Hisamatsu T, Ohkubo T, Fujiyoshi A, Torii S, Segawa H, Kond K, Kadota A, Takashima N, Shitara S, Arima H, Nakagawa Y, Watanabe Y, Shiino A, Nozaki K, Ueshima H, Miura K

    AHA Epidemiology, Prevention, Lifestyle & Cardiometabolic Health 2021 

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    Event date: 2021.5.20 - 2021.5.21

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  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連:滋賀動脈硬化疫学研究

    久松隆史, 大久保孝義, 藤吉朗, 鳥居さゆ希, 瀬川裕佳, 近藤慶子, 門田文, 高島直敬, 設楽智史, 有馬久富, 中川義久, 渡邉嘉之, 椎野顯彦, 野崎和彦, 上島弘嗣, 三浦克之

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    Event date: 2021.1.27 - 2021.1.29

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  • 地域住民におけるJSH2019にもとづく高血圧の有病率・認知率・治療率・管理率:益田研究

    久松隆史, 福田茉莉, 谷口かおり, 宮川健, 中畑典子, 神田秀幸

    第79回日本公衆衛生学会総会 

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    Event date: 2020.10.20 - 2020.10.22

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  • 海外留学ネットワーキングセミナー Invited

    久松隆史

    第84回日本循環器学会学術集会 

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    Event date: 2020.7.27 - 2020.8.2

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  • 降圧剤非服用者における家庭血圧測定による血圧値および高血圧有病率の季節変動性:益田研究

    久松隆史, 谷口かおり, 原田和美, 福田 茉莉, 神田秀幸

    第30回日本疫学会学術総会 

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    Event date: 2020.2.20 - 2020.2.22

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  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討, NIPPON DATA80.

    久松隆史, 三浦克之, 大久保孝義, 門田文, 近藤慶子, 喜多義邦, 早川岳人, 神田秀幸, 岡村智教, 岡山明, 上島弘嗣

    第42回日本高血圧学会総会  2019 

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    Event date: 2019.10.25 - 2019.10.27

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  • 島根県益田市におけるIoTを活用した血圧管理プロジェクト Invited

    久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

    第1回Digital Hypertension Conference  2019.10.25 

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  • Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA Invited International conference

    Takashi Hisamatsu

    Cardiovascular Epidemiology Seminar Series, Northwestern University  2019.1.25 

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  • Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study

    Hisamatsu T, Miura K, Fujiyoshi A, Kunimura A, Shiino A, Nozaki K, Arima H, Ohkubo T, Ueshima H

    第83回日本循環器学会学術集会  2019 

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  • The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Invited

    IDACO/IDHOCO/IDCARS Consortium Meeting 2019  2019 

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  • Objectively measured step counts was independently associated with higher cognition in apparently healthy Japanese men

    AHA EPI Lifestyle 2018 Scientific Sessions  2018 

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  • The Association between Coronary Artery Calcium and the Cerebral Small Vessel Disease

    AHA EPI Lifestyle 2018 Scientific Sessions  2018 

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  • Association of serum N-3 polyunsaturated fatty acids and high-sensitivity C-reactive protein in Japanese general population from Shiga Epidemiological Study of Subclinical Arteriosclerosis

    第82回日本循環器学会学術集会  2018 

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  • Feasibility, safety and efficacy of a modified Dietary Approaches to Stop Hypertension diet for Japanese population

    AHA EPI Lifestyle 2018 Scientific Sessions  2018 

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  • Gut microbiota and coronary artery calcification in a general population of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis

    第82回日本循環器学会学術集会  2018 

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  • A Challenge for Mutation Specific Risk Stratification in Long QT Syndrome Type 1

    第82回日本循環器学会学術集会  2018 

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  • 厳密な安静後の診察室血圧値と家庭血圧値の比較、及びその差に影響を及ぼす要因の検討

    第40回日本高血圧学会総会  2017 

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  • Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men

    第52回日本アルコール・アディクション医学会学術集会  2017 

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  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA

    49回日本動脈硬化学会総会・学術集会  2017 

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  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係

    49回日本動脈硬化学会総会・学術集会  2017 

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  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連

    第53回日本循環器病予防学会学術集会  2017 

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  • 日本版DASH食の開発と食事介入による生体指標の変化の検討 パイロット研究

    第53回日本循環器病予防学会学術集会  2017 

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  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連

    第53回日本循環器病予防学会学術集会  2017 

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  • NMR lipoprotein particle distributions and coronary artery calcium in US White and Japanese men aged 40-49 years

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017 

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  • Prevalence of Intracranial Artery Stenosis and the Association with Conventional Risk Factors of Cardiovascular Dieseases in a General Population of Japanese.

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017 

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  • Lower eGFR and proteinuria were independently associated with lower cognitive abilities in community-dwelling men in Japan

    American Heart Association EPI LIFESTYLE 2017 Scientific Sessions  2017 

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    Presentation type:Poster presentation  

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  • Smoking, smoking cessation and measures of subclinical atherosclerosis in multiple vascular meds in Japanese men.

    ESC CONGRESS 2016.  2016 

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  • 客観的に評価された歩数値とメタボリック症候群との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)

    第52回日本循環器病予防学会学術集会  2016 

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  • Blood pressure measurement in the National Survey in Japan and the future plan for non-mercury era

    The 26th Scientific Meeting of the International Society of Hypertension  2016 

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  • 潜在性動脈硬化の規定要因:ERA JUMP、SESSAより Invited

    久松隆史, 三浦克之, 関川暁, 上島弘嗣

    第47回日本動脈硬化学会総会・学術集会  2015 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • The High Prevalence of Early Repolarization in Genotyped Long QT Syndrome

    Hasegawa K, Watanabe H, Hisamatsu T, Sonoda K, Ohno S, Itoh H, Ashihara T, Makiyama T, Hayashi H, Horie M

    第78回日本循環器学会総会・学術集会 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

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  • Early repolarization in Japanese general population: new findings from the National Surveys of Circulatory Disorders of Japan (NIPPON DATA)

    Hisamatsu T, Miura K, Ohkubo T, Okamura A, Okayama A, Ueshima H

    第78回日本循環器学会総会・学術集会 

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Awards

  • 日本アルコール・アディクション医学会 若手奨励賞

    2022  

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  • 日本疫学会 奨励賞

    2022  

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  • 岡山大学SDGs推進表彰 President Award 岡山県クラスター対策班

    2021  

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  • 岡山公衆衛生学研究会 緒方賞

    2020  

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  • 日本循環器病予防学会 奨励賞

    2018  

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    Country:Japan

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  • 島根大学医学部 若手研究者優秀論文賞

    2017  

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    Country:Japan

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  • 日本動脈硬化学会 若手研究者奨励賞

    2017  

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    Country:Japan

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  • 日本心臓病学会 上田賞

    2015  

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    Country:Japan

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Research Projects

  • 壮年期を対象とした伴走型血圧管理支援事業の役割と評価:社会的処方の観点から

    Grant number:22K11085  2022.04 - 2026.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    福田 茉莉, 神田 秀幸, 久松 隆史, 中畑 典子, 絹田 皆子

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • 外国にルーツを持つ子どものヘルスリテラシー向上を目指すシステム構築

    Grant number:22K11062  2022.04 - 2026.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    土江 梨奈, 神田 秀幸, 福田 誠司, 中島 千惠, 柏木 智子, 久松 隆史, 福田 茉莉

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • 「予防・健康づくりに関する大規模実証事業 (運動、栄養、女性の健康、がん検診)」食行動の変容に向けた尿検査及び食環境整備に係る実証事業

    2021.10 - 2023.03

    厚生労働省 

    久松隆史

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    Authorship:Coinvestigator(s) 

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  • 高校生eスポーツアスリートにおける心身の健康実態の解明

    Grant number:21K10470  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    神田 秀幸, 宮崎 亮, 絹田 皆子, 久松 隆史, 津村 秀樹, 福田 茉莉

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • Longitudinal study on home blood pressure and subclinical cerebrovascular disease

    Grant number:20K10529  2020.04 - 2023.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    久松 隆史, 神田 秀幸, 三浦 克之

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    研究代表者らは、平成29年から島根県益田市の地域住民約1500名(20-74歳)を対象にIoT技術を活用した最長5年間にわたる家庭血圧測定・管理に関するコホート研究(益田研究)を実施中である。本申請研究では、3年超継続して血圧を測定している者を対象として、蓄積された血圧データをもとに血圧変動に関する解析を実施し、頭部MRI検査を追加した。
    血圧変動に関する解析手順書を作成した。記録された血圧データ(毎日、起床後・就寝前・就寝中午前2・3・4時に測定)にもとづき、変動指数として変動係数、最高-最低値差、平均 変動幅、等を用いて、時間的(季節・曜日・時間帯など時間的な偏り)および量的(最大値・変動幅等)な側面から年間・季節・日間・日内の血圧変動を評価した。
    益田地域医療センター医師会病院において頭部MRI検査を実施した。臨床における頭部MRI検査のプロトコールに準じて標準化された調査手順書を作成し、テストラン実施後、プロトコールを確定させた。頭部MRI検査は、3DT1・T2強調画像、T2-STAR、FLAIR、3D-MRAの多彩な撮影方法を用いて実施した。撮影画像をもとに、放射線科医1名が無症候性脳血管障害(ラクナ梗塞・白質病変・微小出血・脳動脈狭窄)の読影を行った。検査結果については、医師が最終判定を行い、コメントと共に対象者に返却した。
    血圧変動解析・頭部MRI検査が完了次第、データクリーニングを行った。血圧変動データ、頭部MRI検査所見、および益田研究データベースを統合したデータベースを完成させた。統合データベースをもとに、年間・季節・日間・日内の血圧変動の実態・関連要因について、横断的な解析を行った。

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  • 血圧変動共振現象の病態解明を目指したWithコロナ時代における遠隔化・省人化・非接触型コホート研究の基盤開発

    2020 - 2022

    公益財団法人岡山医学振興会 

    久松隆史

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  • IoT技術を活用した長期にわたり評価された家庭血圧管理状況と血圧変動要因に関する探索的観察研究

    2018

    共同研究(オムロンヘルスケア株式会社) 

    久松隆史

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  • Arrhythmia and subclinical cerebrovascular disease

    Grant number:17K15827  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Hisamatsu Takashi

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    The association between an increased supraventricular
    ectopic beat (SVEB) and subclinical cerebrovascular disease remains
    unclear.We conducted a population-based study of 462 participants who underwent 24-h Holter electrocardiography and brain magnetic resonance imaging. ESVEA was defined as the presence of >10 SVEBs/h. ESVEA was independently associated with higher burdens of white matter hyperintensity and intracranial artery stenosis, but not with silent brain infarct. This suggests that the effect of increased SVEBs on ischemic stroke may partly occur through development of subclinical cerebrovascular disease.

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  • Association of subclinical thyroid dysfunction with atherosclerosis including silent cerebral lesions in a Japanese general population: a cross-sectional study

    Grant number:16K19250  2016.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Torii Sayuki, Miura Katsuyuki, Ueshima Hirotsugu, Fujiyoshi Akira, Hisamatsu Takashi

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    Little is known regarding the association of subclinical thyroid dysfunction with atherosclerosis including silent cerebral lesions in a general population. We conducted a cross-sectional study in a population-based sample of apparently healthy Japanese men to examine the prevalence of subclinical thyroid dysfunction and the association of those dysfunction with coronary artery/aorta calcification, carotid artery plaque, peripheral artery stenoses and silent cerebral lesions (lacunar infarcts, microbleeds, white matter hyperintensities and brain artery stenoses) evaluated by brain magnetic resonance imaging. The prevalence of subclinical hypothyroidism and hyperthyroidism were 9.5% and 1.6%,respectively. We found no significant associations between subclinical thyroid dysfunction and these atherosclerosis indicators. In conclusion, in a community-based sample of Japanese men, subclinical thyroid dysfunction was not associated with atherosclerosis including silent cerebral lesions.

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  • Relationship among subclinical atherosclerosis, frailty, intramuscular fat, and cross-sectional muscle area assessed by thigh CT

    Grant number:16K09055  2016.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    KADOWAKI SAYAKA, AZUMA KOICHIRO, UESHIMA HIROTSUGU, HISAMATSU TAKASHI, TORII SAYUKI

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    This is an interim report of the first-term result of a study originally planned as a two-term project. The present study is an ancillary study of a large-scale epidemiological study on subclinical atherosclerosis that aims to elucidate the relationship among subclinical atherosclerosis, inter-muscular ectopic fat, and frailty defined as a clinically recognizable state of increased vulnerability resulting from an aging-associated decline in reserve and function across multiple physiologic systems.
    In the interim preliminary analyses, the intermuscular fat accounted for 15% of the thigh muscle tissue, and the frailty and pre-frailty prevalence were 4.0% and 55.5%, respectively, in 276 women (75 ± 6 years old). Thorough analyses and final report will be made at the end of the second-term.

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  • Japanese Paradoxに着目した心血管病の病態理解と新リスク要因の解明

    2016 - 2019

    科学研究費補助金(海外特別研究員) 

    久松隆史

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    Authorship:Principal investigator  Grant type:Competitive

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  • 大規模疫学分析に基づく大動脈弁硬化変性の病態解明

    2016 - 2018

    民間学術研究振興費補助金(上原記念生命科学財団) 

    久松隆史

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  • Subclinical atherosclerosis and brain atrophy in the general Japanese women

    Grant number:15H02528  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    Miura Katsuyuki, HORIE Minoru, TOOYAMA Ikuo, MAEGAWA Hiroshi, SEKIKAWA Akira, OKAMURA Tomonori, OHKUBO Takayoshi, TABARA Yasuharu, OHNO Seiko, KADOWAKI Sayaka, MIYAGAWA Naoko

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    Grant amount:\46410000 ( Direct expense: \35700000 、 Indirect expense:\10710000 )

    The aim of this study is to investigate the prevalence of subclinical atherosclerosis and the brain atrophy in the general population of Japanese women, and to clarify the relevant factors. Our target number of subjects of this study was 800. In 2015-2017, we have successfully conducted survey on 266 women, who were randomly sampled from local residents in Kusatsu city, Shiga. We have performed chest and abdominal computed tomography, head magnetic resonance imaging, carotid artery ultrasound, cognitive function test, physical function tests, blood pressure, blood and urine test, and electrocardiogram to the subjects. We will continue the survey on approximately 500 women additionally in 2018-2021.

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  • Prevalence of COPD and subclinical arteriosclerosis in Japanese general population

    Grant number:15K09171  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Nakano Yasutaka

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    Chronic Obstructive Pulmonary disease (COPD) is one of the most important diseases in Japan. About 500 men aged over 40 years, who were recruited from a general population of Kusatsu city in Shiga Prefecture, underwent lung function tests and brain MRI. The prevalence of COPD was revealed to be about 15%. An association was found between reduced lung function and the white matter lesions and lacunar infarcts in never smokers.

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  • Gut microbiota and sublinical atherosclerosis in general population

    Grant number:15H04773  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Arima Hisatomi, OHNO Seiko, MIYAGAWA Naoko, KADOWAKI Takashi, OKAMI Yukiko

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    Grant amount:\16250000 ( Direct expense: \12500000 、 Indirect expense:\3750000 )

    The aim of the present analysis is to investigate the association between gut microbiota and coronary artery calcification (CAC) in general Japanese men. Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) is a prospective cohort study of randomly selected men from a general Japanese population. This analysis included 669 participants who completed a follow-up examination including analysis of gut microbiota. After adjustment for age, BMI, total cholesterol, HDL cholesterol, HbA1c, smoking, alcohol intake, regular exercise, and use of medication to treat hypertension, dyslipidemia or diabetes, frequency of Lactobacillus was associated with lower risks of coronary artery calcification (odd ratio 0.84 per 1SD [9%] increase, 95%CI 0.70-1.00) while there were no clear relationships for Bifidobacterium, Bacteroides, Prevotella or Clostridium. Lactobacillus appears to be associated with lower prevalence of CAC in a general population of Japanese men.

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  • Serum irisin and obesity, diabetes mellitus, and atherosclerosis

    Grant number:15K19224  2015.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Hisamatsu Takashi

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

    Irisin is a newly discovered myokine. We aimed to examine to the association of serum irisin and obesity, diabetes mellitus, and atherosclerosis. In a community-based apparently healthy adults aged 40-79 years, serum irisin was inversely associated with obesity and lipid indices. In addition, serum irisin was inversely associated with progression of coronary artery calcification independent of confounders including obesity, lipid, and diabetes parameters. Future studies are needed to assess whether irisin is protectively associated with cardiometabolic disease.

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  • 筋強直性ジストロフィー患者の心電図の経時的分析による致死性不整脈の因子分析とデバイス適応の検討

    2015 - 2019

    厚生労働科学研究費補助金 

    久松隆史

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  • The impacts of ectopic fats in muscle, liver, and abdominal tissues on the metabolism related to glucose and insulin

    Grant number:26293140  2014.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Fujiyoshi Akira, MURATA Kiyoshi, MAEGAWA Hiroshi

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    Grant amount:\17160000 ( Direct expense: \13200000 、 Indirect expense:\3960000 )

    As planned, we have finished reading the total of approximately 2,400 images, and cleaned the data of it. Also, we have obtained multiple measures related to glucose-insulin metabolism. Using those data, we have obtained preliminary results as follows: In a population-based samples of men aged 40years or older, 1) older individuals had lower body mass index, smaller muscle areas, but larger fat-muscle areas; 2) age and weight were the major predictors of muscle areas/mass; 3) abdominal visceral adipose tissue was most strongly correlated to glucose, triglycerides and inflammation as compared to other factors we studied.

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  • 認知機能低下・海馬萎縮に関連する心臓調律異常の疫学的検証

    2014 - 2015

    民間学術研究振興費補助金(花王健康科学研究会) 

    久松隆史

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  • Association of heart rate variability with silent cerebral lesions in a Japanese general population: a cross-sectional cohort study

    Grant number:25893097  2013.08 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up  Grant-in-Aid for Research Activity Start-up

    HISAMATSU Takashi

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    Grant amount:\2730000 ( Direct expense: \2100000 、 Indirect expense:\630000 )

    Heart rate variability (HRV) reflects the autonomic nervous system. Little is known regarding the association of HRV with stroke risk in a general population. We conducted a cross-sectional study in a population-based sample of apparently healthy Japanese men to examine the association of nighttime (2 am to 2:15 am) and 24-hour HRV indices (SDNN, LF, HF, LF/HF ratio) quantified by 24-hour electrocardiogram with silent cerebral lesions (lacunar infarcts, microbleeds, white matter hyperintensities, brain artery stenoses) evaluated by brain magnetic resonance imaging. We found no significant associations between these HRV indices and silent cerebral lesions. In conclusion, in a community-based sample of Japanese men without clinical cardiovascular disease, HRV was not associated with silent cerebral lesions.

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  • Explorative Study on new biomarker of atherosclerosis

    Grant number:25253046  2013.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    Ueshima Hirotsugu

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    Grant amount:\46020000 ( Direct expense: \35400000 、 Indirect expense:\10620000 )

    We have reported the association of insulin resistance and progression of coronary artery calcification (CAC), and the association between step count and onset of metabolic syndrome in logitudinal analyses. We also reported a comparative study of CAC between our cohort (Shiga Epidemiological Study of Subclinical Atherosclerosis: SESSA) and a community-based cohort in the US (Multi-Ethnic Study of Atherosclerosis: MESA). In other collaborative studies with University of Pittsburgh, we have reported the association of n-3 fatty acid and CAC. Moreover, we investigated the association between lipoprotein-associated phospholipase A2 and atherosclerosis as well as the association of low density lipoprotein (LDL) cholesterol with polymorphism of aldehyde dehydrogenase. Metabolome in the urine, and oxidized LDL in the blood have been already measured and we will continue to seek for novel biomarkers that are useful in prevention of atherosclerotic diseases.

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  • Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men

    Grant number:23249036  2011.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    MIURA Katsuyuki, UESHIMA Hirotsugu, IMAI Yutaka, MURATA Kiyoshi, NOZAKI Kazuhiko, SHIINO Akihiko, OHKUBO Takayoshi, HOSAWA Atsushi, FUJIYOSHI Akira, HISAMATSU Takashi, HORIE Minoru, TOHYAMA Ikuo, TOTSUNE Kazuhito, ARAI Hiroyuki, MURAKAMI Yoshitaka, KADOTA Aya, KIKUYA Masahiro, NAGASAWA Shin-ya, ASAYAMA Kei, TOMITA Naoki, TAKASHIMA Naoyuki, HIROSE Takuo, SEKIKAWA Akira, KONDO Takeo, MIKI Tetsuro

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    Grant amount:\47190000 ( Direct expense: \36300000 、 Indirect expense:\10890000 )

    Stroke mortality is low in the Western Japan, while high in the Eastern Japan. In this study, we performed brain magnetic resonance imaging (MRI) in participants of cohort studies at Kusatsu (west) and Ohasama (east). First, we conducted MRI in same participants living in Ohasama at both Kusatsu and Ohasama facilities to investigate validity comparing West and East. Kappa coefficients between two facilities were about 0.60 in lacunar infarction and cerebral microbleed, 0.46 in white matter lesion. Then, we compared people in Kusatsu with these in Ohasama aged from 60 to 89 by age. Prevalence of lacunar infarction and that of cerebral microbleed were higher in Ohasama than in Kusatsu, and we thought that it might be occurred because people in Ohasama had higher blood pressure and percentage of medication of hypertension than Kusatsu in baseline characteristics. Meanwhile prevalence of white matter lesion was higher in Kusatsu than in Ohasama. That reason was not clear.

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Class subject in charge

  • Public Health (2021academic year) special  - その他

  • Practice in Public Health (2021academic year) special  - その他

  • Research Projects and Practicals: Public Health I (2021academic year) special  - その他

  • Lecture and Research Projects: Public Health I (2021academic year) special  - その他

  • Research Projects and Practicals: Public Health II (2021academic year) special  - その他

  • Lecture and Research Projects: Public Health II (2021academic year) special  - その他

  • Introduction of Clinical Medical Sciences (2021academic year) special  - その他

  • Public Health (2020academic year) special  - その他

  • Practice in Public Health (2020academic year) special  - その他

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Social Activities

  • いきいきライフのすすめ “フレイル予防”をテーマに フレイルの基礎知識

    Role(s):Lecturer

    岡山県栄養改善協議会  2022.6.16

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  • 心不全講習会「心不全を識る、診る、予防する」

    Role(s):Lecturer

    日本循環器病予防学会 特定非営利活動法人 日本高血圧学会 ノバルティス ファーマ 医学教育助成  2022.6.11

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    Type:Certification seminar

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  • 血圧・脂質異常症・糖尿病の基本的検査の意義と結果の見方

    Role(s):Lecturer

    日本循環器病予防学会  保健指導レベルアップセミナー  2021.1.23

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    Type:Lecture

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  • IoT技術を活用した家庭血圧管理と脳卒中予防に向けた取り組み

    Role(s):Lecturer

    島根県益田市  2020.1.24

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  • 生活習慣と高血圧症

    Role(s):Lecturer

    益田地域医療センター医師会病院  2019.12.6

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    Type:Promotional material

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  • 高血圧治療ガイドライン2019の概要と高血圧予防、高血圧管理の重要性

    Role(s):Lecturer

    島根県  島根県脳卒中対策及び糖尿病対策研修会  2019.11.5

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  • 脳卒中や心筋梗塞にならないための生活のコツ

    Role(s):Lecturer

    2016.12.3

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    Type:Lecture

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  • 尿クレアチニン・アルブミン比, 家庭血圧, 尿ナトカリ比

    Role(s):Media coverage, Advisor

    益田ヘルスケア推進協会  益田ヘルスケア通信  2021.5

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    Type:Promotional material

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  • 高血圧と新型コロナウィルス感染症

    Role(s):Editer, Advisor

    益田ヘルスケア推進協会  益田ヘルスケア通信  2020.10

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