2021/12/21 更新

写真a

タケモト マミ
武本 麻美
TAKEMOTO Mami
所属
岡山大学病院 助教
職名
助教

学位

  • 博士(医学) ( 2004年3月   川崎医科大学 )

研究キーワード

  • アパシー

  • 認知症

  • パーキンソン病

研究分野

  • ライフサイエンス / 神経内科学

学歴

  • 川崎医科大学    

    2000年4月 - 2004年3月

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    国名: 日本国

  • 川崎医科大学    

    1990年4月 - 1996年3月

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    国名: 日本国

経歴

  • 岡山大学   脳神経内科   助教   Research associate

    2016年4月 - 現在

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    国名:日本国

  • 岡山大学   脳神経内科

    2013年4月 - 2016年3月

  • 川崎医科大学   胸部心臓血管外科   助手

    1998年4月 - 2000年3月

  • 川崎医科大学   外科

    1996年5月 - 1998年3月

所属学協会

  • 日本認知症予防学会

    2016年3月 - 現在

  • 日本老年医学会

    2013年4月 - 現在

  • 日本内科学会

    2013年4月 - 現在

  • 日本神経学会

    2013年4月 - 現在

  • 日本認知症学会

    2013年4月 - 現在

委員歴

  • 日本内科学会中国支部   評議員  

    2020年11月 - 現在   

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    団体区分:学協会

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論文

  • Accelerated accumulation of fibrinogen peptide chains with Aβ deposition in Alzheimer's disease (AD) mice and human AD brains. 国際誌

    Zhihong Bian, Toru Yamashita, Xiaowen Shi, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Yoshio Omote, Ryuta Morihara, Koji Abe

    Brain research   1767   147569 - 147569   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Alzheimer's disease (AD) is a common neurodegenerative disease that is characterized by the abnormal accumulation of intracellular and extracellular amyloid-β (Aβ) as well as disruption of the blood brain barrier (BBB). Fibrinogen plays an essential role in regulating thrombosis, wound healing, and other biological functions. In the present study, we investigated the relationship between three polypeptide chains α, β, and γ (FGA, FGB, and FGG) and Aβ deposition in the APP23 plus chronic cerebral hypoperfusion (CCH) mice model as well as the human AD brain. FGA, FGB, and FGG accumulated when Aβ was deposited in neural cells and cerebral vessels. This deposition was significantly higher in AD plus CCH mice models relative to wild-type brains, and in human AD brains compared to control brains. The present study demonstrates that FGA, FGB, and FGG are associated with AD progress, and can thus be potential targets for the diagnosis and therapy of AD.

    DOI: 10.1016/j.brainres.2021.147569

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  • Successful treatment of anti-GAD antibody-associated autoimmune cerebellar ataxia with combined immunotherapies

    Yoshio Omote, Chika Matsuoka, Ryo Sasaki, Nozomi Hishikawa, Yuko Kawahara, Emi Nomura, Namiko Matsumoto, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Anti-glutamic acid decarboxylase (GAD) antibody (Ab)-associated autoimmune cerebellar ataxia (CA) is a rare neurological disorder, and a standardized therapy has not been established. Here, we report on a 58 year-old man with type 1 diabetes mellitus, who developed progressive CA with high levels of serum and cerebrospinal fluid (CSF) anti-GAD-Ab. He was initially treated with intravenous high-dose methylprednisolone and intravenous immunoglobulin (IVIg), but his CA was gradually worsened. Additional combined immunotherapies with plasma exchange, intravenous cyclophosphamide, and rituximab finally stabilized the progressive CA and suppressed the CSF anti-GAD-Ab index. Our case suggests the effectiveness of combined immunotherapies against progressive CA and the usefulness of the CSF anti-GAD-Ab index as a therapeutic indicator.

    DOI: 10.1111/ncn3.12541

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  • Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test. 国際誌

    Koh Tadokoro, Toru Yamashita, Yusuke Fukui, Emi Nomura, Yasuyuki Ohta, Setsuko Ueno, Saya Nishina, Keiichiro Tsunoda, Yosuke Wakutani, Yoshiki Takao, Takahiro Miyoshi, Yasuto Higashi, Yosuke Osakada, Ryo Sasaki, Namiko Matsumoto, Yuko Kawahara, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Koji Abe

    Journal of the neurological sciences   427   117529 - 117529   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0.01 vs NC) and AD (**p < 0.01 vs NC, ##p < 0.01 vs MCI), and correlated well with the mini-mental state examination (MMSE) score (r = 0.57, *p < 0.05). Furthermore, the eye tracking test, especially memory and deductive reasoning tasks, effectively discriminated NC, MCI and AD. The present novel eye tracking test clearly discriminated cognitive functions among NC, MCI, and AD subjects, thereby providing an advantage for the early detection of MCI and AD in screening.

    DOI: 10.1016/j.jns.2021.117529

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  • A case of rheumatoid meningoencephalitis induced by pembrolizumab

    Chika Matsuoka, Yoshio Omote, Yuko Kawahara, Ryo Sasaki, Namiko Matsumoto, Ko Tadokoro, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Immune checkpoint inhibitors occasionally cause various side effects, but the occurrence of a severe immune-related adverse event (irAE) is rare in neurology. We report on a 56-year-old woman who suffered from rheumatoid arthritis and recurrent uterine cancer. After treatment with pembrolizumab, she showed visual disturbance followed by acute fever and consciousness disturbance with high-intensity lesions around the midbrain aqueduct and bilateral caudate heads on FLAIR images of a brain MRI. Her symptoms improved after steroid therapy. However, symptoms relapsed leading to an elevation of the anti-CCP antibody index. Pembrolizumab-induced rheumatoid meningoencephalitis was suspected, so additional steroid therapy was provided. This improved her symptoms, turning the anti-CCP antibody index negative. The present case is the first case of rheumatoid meningoencephalitis induced by pembrolizumab. The combination of MRI findings and elevated anti-CCP index seems useful for diagnosing rheumatoid meningoencephalitis.

    DOI: 10.1111/ncn3.12540

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  • Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. 国際誌

    Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Abe

    Neuroscience   466   47 - 57   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The degradation of damaged proteins takes place via two major proteolytic pathways: the ubiquitin-proteasome system (UPS) and autophagy. However, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), we investigated the switching mechanism from UPS to autophagy by pharmacologically modifying these pathways by treating the spinal cords of female ALS mouse model bearing G93A human SOD1 (G93A mice) with MG132 or 3-methyladenine (3MA). G93A mice exhibited a progressive increase in the amount of ubiquitin and p62 aggregates, BAG3 expression, and LC3-II/LC3-I ratio in both astroglia and motor neurons. Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated α-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression. This study's results demonstrate that the molecular switch from UPS to autophagy occurred not only in motor neurons but also in astroglia at the end stage (18 weeks) when the autophagic flux was impaired in G93A mice. This finding suggests that the defense system was disrupted against aggregate-prone protein production in ALS.

    DOI: 10.1016/j.neuroscience.2021.04.034

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  • A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome.

    Namiko Matsumoto, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yoshio Omote, Mami Takemoto, Toru Yamashita, Kohei Taniguchi, Koji Abe

    Internal medicine (Tokyo, Japan)   60 ( 13 )   2125 - 2128   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case.

    DOI: 10.2169/internalmedicine.6098-20

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  • The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration

    Yuki Taira, Yoshio Omote, Yuko Kawahara, Emi Nomura, Ryo Sasaki, Namiko Matsumoto, Chika Matsuoka, Mami Takemoto, Ryuta Morihara, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 4 )   346 - 348   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We report on a 35-year-old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness and numbness in the extremities and displayed demyelinating neuropathy, detected by nerve conduction studies and a sural nerve biopsy. Repeated intravenous immunoglobulin (IVIg) therapy and the administration of oral prednisolone improved symptoms and inhibited their recurrence. A relatively high level of serum testosterone as a genetic female might have caused the neurotoxicity of the peripheral nerve, leading to CIDP.

    DOI: 10.1111/ncn3.12514

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  • Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

    Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Koh Tadokoro, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Mari Dezawa, Koji Abe

    Scientific reports   11 ( 1 )   12828 - 12828   2021年6月

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  • Hypoxic stress visualized in the cervical spinal cord of ALS patients. 国際誌

    Yamashita T, Hatakeyama T, Sato K, Fukui Y, Hishikawa N, Takemoto M, Ohta Y, Nishiyama Y, Kawai N, Tamiya T, Abe K

    Neurol Res   43 ( 6 )   429 - 433   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/01616412.2020.1866383

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  • Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. 国際誌

    Shi X, Ohta Y, Nakano Y, Liu X, Tadokoro K, Feng T, Nomura E, Tsunoda K, Sasaki R, Matsumoto N, Osakada Y, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Yamashita T, Abe K

    Neuroscience Res   166   55 - 61   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neures.2020.05.009

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  • Positive baseline behavioral and psychological symptoms of dementia predict a subsequent cognitive impairment in cognitively normal population

    Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Noriko Hatanaka, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 3 )   218 - 222   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Background: Because behavioral and psychological symptoms of dementia (BPSD) are sometimes prodromal symptoms of dementia, it is important to investigate the relationship between BPSD and subsequent cognitive decline.Methods: We examined the cognitive and affective functions of 76 cognitively normal subjects at initial assessment (baseline) and 1-year follow-up. Cognitive function was assessed using clinical dementia rating (CDR) and Mini-Mental State Examination (MMSE), and affective function was assessed using Abe's BPSD score (ABS) and mild behavioral impairment (MBI).Results: Although there was no change in MMSE, ABS, or MBI after 1 year, the mean CDR score of 0 at baseline increased to 0.1 +/- 0.2 at 1-year follow-up (**P < 0.01 vs baseline). No significant change in MMSE was found in both baseline ABS and MBI positive- or negative-groups. In contrast, baseline MBI-dependent CDR change showed a 13.2% of worsening in MBI-negative subjects and a 62.5% of MBI-positive subjects (dagger dagger P < 0.01), but ABS not.Conclusion: The present data indicate that positive baseline BPSD with MBI was closely related to a subsequent CDR exacerbation. Examining BPSD may be useful for screening cognitively normal population for subsequent dementia development in local communities.

    DOI: 10.1111/ncn3.12492

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  • 4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients. 国際誌

    Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Watanabe, Kentaro Deguchi, Koji Tokunaga, Susumu Sasada, Kazuki Kobayashi, Ryosuke Maeoka, Kenji Fukutome, Kenkichi Takahashi, Hiroyuki Ohnishi, Yoshihiro Kuga, Hideyuki Ohnishi, Koji Abe

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   30 ( 3 )   105583 - 105583   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The relationship between stroke etiology and clot pathology remains controversial. MATERIALS AND METHODS: We performed histological analysis of clots retrieved from 52 acute ischemic stroke patients using hematoxylin and eosin staining and immunohistochemistry (CD42b and oxidative/hypoxic stress markers). The correlations between clot composition and the stroke etiological group (i.e., cardioembolic, cryptogenic, or large artery atherosclerosis) were assessed. RESULTS: Of the 52 clots analyzed, there were no significant differences in histopathologic composition (e.g., white blood cells, red blood cells, fibrin, and platelets) between the 3 etiological groups (P = .92). By contrast, all large artery atherosclerosis clots showed a localized pattern with the oxidative stress marker 4-hydroxyl-2-nonenal (P < .01). From all 52 clots, 4-hydroxyl-2-nonenal expression patterns were localized in 28.8% of clots, diffuse in 57.7% of clots, and no signal in 13.5% of clots. CONCLUSIONS: A localized pattern of 4-hydroxyl-2-nonenal staining may be a novel and effective marker for large artery atherosclerosis (sensitivity 100%, specificity 82%).

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.105583

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  • A new telestroke network system in northern area of Okayama prefecture

    Ryo Sasaki, Toru Yamashita, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Taijun Yunoki, Kazuki Kobayashi, Takashi Sawata, Yuki Sato, Junichi Kubota, Masayuki Mizobuchi, Takashi Hayashi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 2 )   166 - 170   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Background: Telestroke network can provide rapid access to specialized treatment and improves on-site management of acute stroke patients through the "hub-and-spoke" model. In the northern part of Okayama Prefecture, there has been a regional gap of stroke care due to the shortage of stroke specialists and facilities. In addition, due to the novel coronavirus disease 2019 (COVID-19), it is required to reduce the unnecessary contact with stroke patients from other hospitals.Aim: We organized a novel cost-free telestroke network with an image and video sharing for neurological diseases in the northern part of Okayama Prefecture to improve the stroke management in the area.Method: We prepared the tablet device on which Skype(R) application was installed for each hospital and recruited the patients who visited or hospitalized in the spoke hospitals and were suspected to have some neurological diseases from April 2019 to May 2020. The patient's clinical data were recorded and analyzed.Results: During the study period, 5 patients were recruited including the cases with the initial diagnosis of stroke or brain tumor. Among them, 2 cases were transferred to the hub hospital, 2 cases were transferred to other hospitals, and 1 case was treated on site under specialist's advice.Conclusion: The new telestroke network system may be beneficial for acute stroke management and reducing the unnecessary patient's transfer in the rural area, especially under coexistence with COVID-19.

    DOI: 10.1111/ncn3.12475

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  • The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years After the First Instance of Optic Neuritis.

    Nomura E, Kawahara Y, Omote Y, Tadokoro K, Takemoto M, Hishikawa N, Yamashita T, Ogata H, and Abe K

    Intern Med   60 ( 2 )   305 - 308   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.5536-20

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  • A case of autoimmune GFAP astrocytopathy with profound weight loss and increased uptake in the spinal cord on 18F‐FDG PET.

    Osakada Y, Omote Y, Ikegami K, Tadokoro K, Sato k, Hishikawa N, Takemoto M, Ohta Y, Yamashita T, Kimura A, Abe K

    Neurology Clinical Neurosci   9 ( 1 )   95 - 97   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12441

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  • A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging.

    Ohta Y, Shimada H, Ikegami K, Tsunoda K, Hishikawa N, Yamashita T, Takemoto M, Omote Y, Tagai K, Matsuoka K, Higuchi M, Abe K

    Neurol Clin Neurosci.   9 ( 1 )   124 - 126   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12463

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  • Retinal Amyloid Imaging for Screening Alzheimer's Disease. 国際誌

    Koh Tadokoro, Toru Yamashita, Shuhei Kimura, Emi Nomura, Yasuyuki Ohta, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Yuki Morizane, Koji Abe

    Journal of Alzheimer's disease : JAD   83 ( 2 )   927 - 934   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cost-effective and noninvasive methods for in vivo imaging of amyloid deposition are needed to screen Alzheimer's disease (AD). Although retinal amyloid is a possible diagnostic marker of AD, there are very few studies on in vivo retinal amyloid imaging. OBJECTIVE: To examine the usefulness of in vivo imaging of retinal amyloid in AD patients. METHODS: To examine amyloid deposition, 30 Japanese subjects (10 normal control (NC), 7 with mild cognitive impairment (MCI), and 13 with AD) underwent a complete ophthalmic examination, including fundus imaging by scanning laser ophthalmoscopy before and after oral curcumin intake. RESULTS: Retinal amyloid deposition was greater in AD than in NC subjects (*p < 0.05) while MCI showed a slight but insignificant increase of retinal amyloid deposition relative to NC subjects. Retinal amyloid deposition was correlated with whole gray matter atrophy (r = 0.51, *p < 0.05) but not with the cognitive score of the Mini-Mental State Examination, nor with medial temporal lobe atrophy. CONCLUSION: The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening AD patients.

    DOI: 10.3233/JAD-210327

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  • Immediate Beneficial Effect of Makeup Therapy on Behavioral and Psychological Symptoms of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. 国際誌

    Koh Tadokoro, Toru Yamashita, Satoko Kawano, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Natsuki Sagawa, Tomiko Tani, Koji Abe

    Journal of Alzheimer's disease : JAD   83 ( 1 )   57 - 63   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Possible benefits of makeup therapy, in terms of immediate and late effects on cognitive and affective functions, have not been fully proved for dementia patients. OBJECTIVE: To evaluate the immediate effect of makeup therapy on dementia patients. METHODS: Female nursing home residents with dementia received either only skin care treatment (control group, n = 17) or skin care plus makeup therapy treatment (makeup therapy group, n = 19). Cognitive, affective, and activity of daily living (ADL) scores were evaluated before and just after treatments. Apparent age and emotion were also evaluated with artificial intelligence (AI) software. RESULTS: Makeup therapy significantly improved Abe's behavioral and psychological symptoms of dementia (BPSD) score (ABS, *p < 0.05). AI software judged that makeup therapy significantly made the apparent age younger (*p < 0.05). In particular, patients with moderate ADL scores had a significantly higher happiness score in makeup therapy (*p < 0.05), with a modest correlation to the Mini-Mental State Examination (MMSE, r = 0.42, *p < 0.05). The severe baseline MMSE group reported a greater feeling of satisfaction following makeup therapy (*p < 0.05). CONCLUSION: The present makeup therapy is a promising non-pharmacological approach to immediately alleviate BPSD in female dementia patients, and the present AI software quickly and quantitatively evaluated the beneficial effects of makeup therapy on facial appearance.

    DOI: 10.3233/JAD-210284

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  • Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging. 国際誌

    Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Koh Tadokoro, Yoshio Omote, Ryuta Morihara, Koji Abe

    Journal of Alzheimer's disease : JAD   80 ( 1 )   331 - 335   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. OBJECTIVE: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99 mTc-ECD SPECT subtraction images of these two diseases. METHODS: We examined 112 patients with PD (53 males and 59 females; age: 77.4±3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1±6.7 years) using brain magnetic resonance imaging (MRI) and 99 mTc-ECD SPECT subtraction imaging. RESULTS: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7±1.1) than the latter (0.2±0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99 mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. CONCLUSION: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.

    DOI: 10.3233/JAD-201495

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  • A case of tocilizumab-induced leukoencephalopathy with a reversible clinical course.

    Sasaki R, Hishikawa N, Nomura E, Omote Y, Takemoto M, Yamashita T, Hatanaka N, Higashi Y, Abe K

    Intern Med   59 ( 22 )   2927 - 2930   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.5288-20

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  • Repeat sizes of NOP56 gene in a Japanese Asidan (SCA36) family with clinical anticipation. 国際誌

    Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

    J Neurol Sci   418   117150 - 117150   2020年11月

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  • Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

    Yamashita T, Kushida Y, Wakao S, Tadokoro K, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Dezawa M, Abe K

    Scientific Reports   10 ( 1 )   17102 - 17102   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-74216-4

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  • Direct arterial damage and neurovascular unit disruption by mechanical thrombectomy in a rat stroke model.

    Sasaki R, Yamashita T, Tadokoro K, Matsumoto N, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    J Neurosci Res   98 ( 10 )   2018 - 2026   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jnr.24671

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  • Clinical anticipation of disease onset in a Japanese Asidan (SCA36) family. 国際誌

    Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

    J Neurol Sci   416 ( 15 )   117043 - 117043   2020年9月

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  • A Case of Triple Seronegative Myasthenia Gravis with Graves’ Disease Ameliorated after the Removal of Enlarged Thymus with elevated uptake in fluorine‐18 fluorodeoxyglucose positron emission tomography.

    Matsumoto N, Omote Y, Nakano Y, Takemoto M, Hishikawa N, Sato K, Ohta Y, Yamashita T, Toji T, Abe K

    Neurol Clin Neurosci   8 ( 5 )   313 - 316   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12414

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  • Dynamic changes and mislocalizations of neurodegenerative disease-related proteins in mice stroke model.

    Liu X, Yamashita T, Shi X, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Brain Res   1742 ( 1 )   146862   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.brainres.2020.146862

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  • A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation.

    Sasaki R, Omote Y, Tadokoro K, Matsumoto N, Nomura E, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, and Abe K

    Neurology Asia   25 ( 3 )   415 - 418   2020年9月

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    記述言語:英語  

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  • Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients.

    Ohta Y, Yamashita T, Nomura E, Hishikawa N, Ekegami K, Osakada Y, Matsumoto N, Kawahara Y, Yunoki T, Takahashi Y, Takamiya M, Tadokoro K, Sasaki R, Nakano Y, Tsunoda K, Sato K, Omote Y, Takemoto M, Abe K

    J Neurol Sci   415 ( 15 )   116906   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2020.116906

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  • Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model. 国際誌

    Taira Y, Yamashita T, Bian Y, Shang J, Matsumoto N, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    J Stroke Cerebrovasc Dis   29 ( 8 )   104818 - 104818   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.104818

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  • PDDとDLBの認知機能と情動機能、脳血流画像の比較

    武本 麻美, 田所 功, 表 芳夫, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    日本老年医学会雑誌   57 ( Suppl. )   111 - 112   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.

    Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Brain Research   1739 ( 15 )   146831   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.brainres.2020.146831

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  • Adult‐onset frequent non‐convulsive status epilepticus in a patient with ring chromosome 20 syndrome.

    Liu X, Omote Y, Ikegami K, Tadokoro K, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

    Neurol Clin Neurosci   8 ( 4 )   202 - 204   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12389

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  • Familial dropped head syndrome with extremity muscle weakness.

    Tsunoda K, Hishikawa N, Omote Y, Ikegami K, Nakano Y, Sato K, Takemoto M, Ohta Y, Yamashita T, Abe K

    Neurol Clin Neurosci   8 ( 4 )   189 - 191   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12382

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  • Bone Marrow Stromal Cell Transplantation Drives Molecular Switch from Autophagy to the Ubiquitin-Proteasome System in Ischemic Stroke Mice.

    Tadokoro K, Fukui Y, Yamashita T, Liu X, Tsunoda K, Shang J, Morihara R, Nakano Y, Feng T, Sasaki R, Matsumoto N, Nomura E, Shi X, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    J Stroke Cerebrovasc Dis   29 ( 5 )   104743   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.104743

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  • Diabetic painful truncal neuropathy with hypohidrosis and facial palsy.

    Tsunoda K, Omote Y, Hishikawa N, Ikegami K, Nakano Y, Sato K, Takemoto M, Ohta Y, Yamashita T, Deguchi K, Abe K

    Neurol Clin Neurosci   8 ( 3 )   155 - 157   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12370

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  • A spontaneous recovery of anti‐galactocerebroside antibody‐associated encephalitis without evidence of Mycoplasma infection.

    Tadokoro K, Omote Y, Osakada Y, Ikegami K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

    Neurol Clin Neurosci   8 ( 3 )   164 - 166   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12379

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  • Discrepancy of subjective and objective sleep problems in Alzheimer’s disease and mild cognitive impairment detected by a home-based sleep analysis.

    Tadokoro K, Ohta Y, Hishikawa N, Nomura E, Wakutani Y, Takao Y, Omote Y, Takemoto M, Yamashita T, Abe K

    J Clin Neurosci   74   76 - 80   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jocn.2020.01.085

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  • A unique case of myasthenia gravis mimicking Garcin’s syndrome.

    Tadokoro K, Hishikawa N, Ikegami K, Nomura E, Kawahara Y, Omote Y, Takemoto M, Yamashita T, Abe K

    Neurol Clin Neurosci   1 - 4   2020年4月

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    記述言語:英語  

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  • Delayed Serial Microvascular Injury and Cognitive Decline After Whole Brain Irradiation.

    Osakada Y, Yamashita T, Ikegami K, Kawahara Y, Omote Y, Hishikawa N, Takemoto M, Ohta Y, Abe K

    Japanese Society of Vascular Cognitive Impairment   6   23 - 26   2020年4月

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    記述言語:英語  

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  • A juvenile case of idiopathic hypertrophic pachymeningitis involved cavernous sinus and proximal trigeminal nerve.

    Bian Z, Omote Y, Tadokoro K, Ikegami K, Osakada Y, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

    J Clin Neurosci   8 ( 2 )   82 - 85   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12355

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  • A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

    Namiko Matsumoto, Kota Sato, Nozomi Hishikawa, Yuko Kawahara, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Kentaro Fujii, Kazuhiko Kurozumi, Isao Date, Toshiyuki Takahashi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 2 )   92 - 95   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

    DOI: 10.1111/ncn3.12364

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  • LGI1 antibody‐associated limbic encephalitis started from unilateral basal ganglia to medial temporal lobe and insula.

    Liu X, Omote Y, Osakada Y, Tadokoro k, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

    Neurol Clin Neurosci. (2019) Epub ahead of print   8 ( 2 )   68 - 71   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12351

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  • Different clinical and neuroimaging features of Japanese dementia siblings with a new N-terminal mutation (Val225Ala) of APP gene

    Yasuyuki Ohta, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yosuke Osakada, Mami Takemoto, Toru Yamashita, Yoshio Omote, Takeshi Ikeuchi, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   72   482 - 484   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Autosomal dominant amyloid precursor protein (APP) mutations in familial Alzheimer's disease accelerate the amyloid beta (A beta) pathology. Here we describe Japanese siblings with a new N-terminal mutation (a heterogeneous c.674T>C, p.Val225Ala) of the APP gene, developing a progressive dementia at 57 years and A beta and tau pathologies in cerebrospinal fluid studies. However, the brother and sister showed different clinical and neuroimaging features, suggesting different A beta pathologies for each sibling. (C) 2019 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2019.11.009

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  • Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model.

    Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Journal of Cerebral Blood Flow & Metabolism   40 ( 1 )   214 - 224   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0271678X18810617

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  • A dramatic increase in serum CK levels after switching from oral to intravenous administration of LEV.

    Takemoto M, Sato K, Hishikawa N, Yamashita T, Ohta Y, Shang J, Abe K

    Neurol Clin Neurosci   8 ( 1 )   39 - 41   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12336

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  • A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.

    Abe K, Shang J, Shi X, Yamashita T, Hishikawa N, Takemoto M, Morihara R, Nakano Y, Ohta Y, Deguchi K, Ikeda M, Ikeda Y, Okamoto K, Shoji M, Takatama M, Kojo M, Kuroda T, Ono K, Kimura N, Matsubara E, Osakada Y, Wakutani Y, Takao Y, Higashi Y, Asada K, Senga T, Lee LJ, Tanaka K

    J Alzheimers Dis   73 ( 1 )   217 - 227   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-191016

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  • A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology

    Koji Abe, Jingwei Shang, Xiaowen Shi, Toru Yamashita, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Lyang Ja Lee, Kenji Tanaka

    Journal of Alzheimer's Disease   73 ( 1 )   217 - 227   2020年

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    掲載種別:研究論文(学術雑誌)  

    © 2020-IOS Press and the authors. All rights reserved. Background: Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer's disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid-β (Aβ), plasma tau, and serum antibodies for Aβ1-42 are not yet well established. Objective: We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology. Methods: With only 1.5μl of serum, we examined a new target plate 'BLOTCHIP®' plus a matrix-Assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n=100), MCI (n=60), and AD (n=99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains. Results: Apart from Aβ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (∗∗∗p<0.001). MMSE score was well correlated to brain Aβ deposition and to SPD of AD. The mother proteins of the four peptides were upregulated for coagulation, complement, and plasticity (three proteins), and was downregulated for anti-inflammation (one protein) in AD brains. Conclusion: The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage.

    DOI: 10.3233/JAD-191016

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  • The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP) 国際誌

    Takemoto M, Ohta Y, Hishikawa N, Yamashita T, Nomura E, Tsunoda K, Sasaki R, Tadokoro K, Matsumoto N, Omote Y, Abe K

    J Alzheimers Dis   76 ( 2 )   769 - 772   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-200247

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  • A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption. 国際誌

    Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura M, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Curr Neurovasc Res   17 ( 3 )   286 - 293   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2174/1567202617666200517105727

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  • Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment.

    Tsunoda K, Yamashita T, Osakada Y, Sasaki R, Tadokoro K, Matsumoto N, Nomura E, Morihara R, Nakano Y, Takahashi Y, Hatanaka N, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    J Alzheimers Dis.   73 ( 1 )   209 - 215   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-190669

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  • Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease.

    Ohta Y, Nomura E, Hatanaka N, Osakada Y, Matsumoto N, Sasaki R, Tsunoda K, Takemoto M, Tadokoro K, Hishikawa N, Wakutani Y, Yamashita T, Sato K, Omote Y, Abe K

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   70   96 - 101   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jocn.2019.08.062

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  • Intracranial invasive fungal aneurysm due to Aspergillus sinusitis successflly treated by voriconazle plus interal carotid artery ligation therapy in an aged woman.

    Takemoto M, Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Yamashita T, Hishikawa N, Sang JW, Hiramatsu M, Sugiu K, Hishikawa T, Date I, Abe K

    Neurology Asia   24 ( 4 )   363 - 367   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.

    Hishikawa N, Takahashi Y, Fukui Y, Tokuchi R, Furusawa J, Takemoto M, Sato K, Yamashita T, Ohta Y, Abe K

    Neurological research   41 ( 11 )   1001 - 1007   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/01616412.2019.1672380

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  • Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction.

    Sasaki R, Ohta Y, Sato K, Tadokoro K, Takahashi Y, Shang J, Takemoto M, Hishikawa N, Yamashita T, Ishiura H, Tsuji S, Abe K

    Internal medicine (Tokyo, Japan)   58 ( 21 )   3163 - 3165   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.2765-19

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  • パーキンソン病とレビー小体型認知症の検査所見やmicrobleeds出現頻度の違いについて

    武本 麻美, 佐藤 恒太, 太田 康之, 山下 徹, 菱川 望, 阿部 康二

    臨床神経学   59 ( Suppl. )   S266 - S266   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • 時間で追う脳虚血の病態と治療:(2)亜急性期 虚血脳内グリア細胞から神経細胞を誘導するダイレクトリプログラミング法の確立

    山下 徹, 商 敬偉, 中野 由美子, 森原 隆太, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    脳循環代謝   31 ( 1 )   65 - 65   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • Chronic cerebral hypoperfusion alters amyloid-β transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse.

    Shang J, Yamashita T, Tian F, Li X, Liu X, Shi X, Nakano Y, Tsunoda K, Nomura E, Sasaki R, Tadokoro K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Brain research   1723   146379 - 146379   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.brainres.2019.146379

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  • A unique stroke case with contralateral sulcal hyperintensity on fluid-attenuated inversion recovery image changed to linear serpiginous structures

    Osakada Y, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

    Neurol Clin Neurosci   7 ( 6 )   351 - 353   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12327

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  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people

    Nozomi Hishikawa, Yoriko Takahashi, Yusuke Fukui, Ryo Tokuchi, Junichi Furusawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGICAL RESEARCH   41 ( 11 )   1001 - 1007   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga (?Yoga-plus?) among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ? 8.7 years old) participated in a 12-month (M) exercise program at a health and welfare center, a day service center, and a nursing home. Cognitive, affective, and physical functions, and activities of daily living (ADL), were compared at baseline (0M), 6M and 12M of exercise intervention. Results: Mean scores on the frontal assessment battery, clock drawing test, cube copying test, letter fluency, and category fluency significantly improved after the Yoga-plus intervention, while mini-mental state examination, Hasegawa dementia score-revised, and trail-making test performance were relatively stable. Affective scores on the geriatric depression scale (GDS), apathy scale (AS) and Abe?s behavioral and psychological symptoms of dementia were not significantly affected by exercise therapy, but subgroups with higher baseline GDS (GDS ? 5) and AS (AS ? 16) scores showed a significant improvement after intervention. One-leg standing time and 3-m timed up and go test performance significantly improved after 12M intervention. Discussion: Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals.

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  • 筋萎縮性側索硬化症患者の前頭葉機能の特徴

    太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 表 芳夫, 阿部 康二

    Dementia Japan   33 ( 4 )   529 - 529   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

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  • アルツハイマー病の進行に関する臨床的予測因子(Clinical predictors of Alzheimer's disease progression)

    菱川 望, 表 芳夫, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    Dementia Japan   33 ( 4 )   523 - 523   2019年10月

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    記述言語:英語   出版者・発行元:(一社)日本認知症学会  

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  • 多発性の大脳・脳幹病変を認め、診断及び治療に苦慮した抗MOG抗体関連症候群の1例

    松本 菜見子, 佐藤 恒太, 河原 由子, 武本 麻美, 菱川 望, 表 芳夫, 商 敬偉, 太田 康之, 山下 徹, 藤井 謙太郎, 黒住 和彦, 伊達 勲, 阿部 康二

    神経治療学   36 ( 6 )   S251 - S251   2019年10月

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    記述言語:日本語   出版者・発行元:(一社)日本神経治療学会  

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  • Sleep problems in subacute myelo-optico neuropathy (SMON)

    Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   68   128 - 133   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Subacute myelo optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 <= Athens Insomnia Scale score) was 89.6% among SMON patients, which was significantly higher than among control participants 54.4%. Sleep quality measured with the Pittsburgh Sleep Quality Index (PSQI) revealed that the prevalence of poor sleepers (6 <= PSQI score) was higher among SMON patients than control participants (75.6% vs 39.6%, respectively). Subscale analyses of rapid eye movement sleep behavior disorder screening questionnaire revealed that scores on two items ("dreams match nocturnal behavior" and "limb movements") were significantly higher among SMON patients than control participants. In addition, daytime sleepiness scores were significantly higher among SMON patients than control participants (4 <= Epworth Sleepiness Scale scores: 54.0% vs 29.0%, respectively). The current study revealed that most SMON patients suffer from insomnia with dissatisfactory sleep quality, likely due to their long-term physical sequelae. Moreover, SMON patients showed higher rates of daytime sleepiness and sleep medication intake, which could be related to reduced activity during the day, as well as insomnia. (C) 2019 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2019.07.013

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  • Sleep problems in subacute myelo-optico neuropathy (SMON)

    Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

    Journal of Clinical Neuroscience   68   128 - 133   2019年10月

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    掲載種別:研究論文(学術雑誌)  

    © 2019 Elsevier Ltd Subacute myelo-optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 ≤ Athens Insomnia Scale score) was 89.6% among SMON patients, which was significantly higher than among control participants 54.4%. Sleep quality measured with the Pittsburgh Sleep Quality Index (PSQI) revealed that the prevalence of poor sleepers (6 ≤ PSQI score) was higher among SMON patients than control participants (75.6% vs 39.6%, respectively). Subscale analyses of rapid eye movement sleep behavior disorder screening questionnaire revealed that scores on two items (“dreams match nocturnal behavior” and “limb movements”) were significantly higher among SMON patients than control participants. In addition, daytime sleepiness scores were significantly higher among SMON patients than control participants (4 ≤ Epworth Sleepiness Scale scores: 54.0% vs 29.0%, respectively). The current study revealed that most SMON patients suffer from insomnia with dissatisfactory sleep quality, likely due to their long-term physical sequelae. Moreover, SMON patients showed higher rates of daytime sleepiness and sleep medication intake, which could be related to reduced activity during the day, as well as insomnia.

    DOI: 10.1016/j.jocn.2019.07.013

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  • Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.

    Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   28 ( 10 )   104310 - 104310   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.104310

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  • Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.

    Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K

    Neuroscience   416   126 - 136   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neuroscience.2019.07.050

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  • Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis.

    Nakano Y, Tsunoda K, Yamashita T, Mitsui J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Toda T, Tsuji S, Abe K

    Neuro Clin Neurosci   7 ( 5 )   288 - 290   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12317

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  • Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model.

    Nomura E, Ohta Y, Tadokoro K, Shang J, Feng T, Liu X, Shi X, Matsumoto N, Sasaki R, Tsunoda K, Sato K, Takemoto M, Hishikawa N, Yamashita T, Kuchimaru T, Kizaka-Kondoh S, Abe K

    Neuroscience   415   31 - 43   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neuroscience.2019.06.025

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  • A Japanese patient with a VCP mutation c.290G > A (p.G97E) presenting a rapid progressive respiratory failure.

    Nomura E, Ohta Y, Sato K, Kawahara Y, Takemoto M, Takahashi Y, Matsumoto N, Yunoki T, Yamashita T, Hishikawa N, Nishino I, Abe K

    Neuro Clin Neurosci   7 ( 6 )   361 - 364   2019年8月

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  • A Unique Recurrent Stroke Case due to Bilateral Vertebral Artery Dissection with Familial Hirschsprung Disease

    Kota Sato, Ryo Sasaki, Yasuyuki Ohta, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   28 ( 8 )   e113 - e115   2019年8月

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    掲載種別:研究論文(学術雑誌)  

    © 2019 Elsevier Inc. Vertebral artery (VA) dissection is one major cause of brain infarction in young and middle-aged adults. Risk factors for VA dissection are hypertension, diabetes mellitus, hyperlipidemia, trauma, and genetic factors. A 32-year-old man with familial Hirschsprung disease at the age of 2 presented cerebellar ischemic stroke due to bilateral VA dissections. A stroke recurred within 17 days despite oral dual antiplatelet therapy. Bilateral VA dissections and recurrent dissections are related to genetic mutations associated with connective tissue diseases. A part of familial Hirschsprung disease has genetic factors in common with cerebrovascular disease. There may be a common genetic background between his VA dissection and Hirschsprung disease.

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.04.035

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  • Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.

    Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   28 ( 7 )   1993 - 2002   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.029

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  • In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia.

    Yamashita T, Shang J, Nakano Y, Morihara R, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Scientific reports   9 ( 1 )   10956 - 10956   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-019-47482-0

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  • A pneumococcal meningoencephalitis with a small spleen.

    Tsunoda K, Sato K, Takahashi Y, Tadokoro K, Sasaki R, Nomura E, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Neurol Clin Neurosci   7 ( 4 )   215 - 217   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12290

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  • Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse.

    Shang J, Yamashita T, Zhai Y, Nakano Y, Morihara R, Li X, Tian F, Liu X, Huang Y, Shi X, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Neuroscience research   143   61 - 70   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neures.2018.06.002

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  • Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis.

    Ohta Y, Nomura E, Shang J, Feng T, Huang Y, Liu X, Shi X, Nakano Y, Hishikawa N, Sato K, Takemoto M, Yamashita T, Abe K

    Journal of neuroscience research   97 ( 5 )   607 - 619   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jnr.24368

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  • Very rare solitary primary peripheral nerne onset cytotoxic molecule - positive peripheral T- cell lymphoma(PTCL).

    Matsumoto N, Sato K, Takahashi Y, Kawahara Y, Yunoki T, Shang J-W, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Sakamoto M, Kondou E, Shibata R, Yoshino T, Ozaki T, Abe K

    Neurology and Clinical Neuroscience   7 ( 3 )   146 - 149   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12280

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  • Multi‐modal combination therapy rescued a frequent ischemic stroke patient due to giant cell arteritis. 査読

    Takahashi Y, Sato K, Matsumoto N, Kawahara Y, Yunoki T, Shang J, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

    Neurol Clin Neurosci   7 ( 3 )   132 - 135   2019年5月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12266

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  • Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C.

    Matsumoto N, Ohta Y, Deguchi K, Kishida M, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Watanabe A, Yokote K, Takemoto M, Oshima J, Abe K

    Internal medicine (Tokyo, Japan)   58 ( 7 )   1033 - 1036   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1816-18

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  • A Japanese family of autosomal dominant cerebral small vessel disease with heterozygous HTRA1 mutation showing dementia, gait disturbance and subarachnoid hemorrhage.

    Yamashita T, Nozaki H, Wakutani Y, Tadokoro K, Nomura E, Takahashi Y, Sato K, Hishikawa N, Takemoto M, Shang J, Ohta Y, Onodera O, Abe K

    Vas-Cog Journal   5   20 - 26   2019年4月

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  • Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model.

    Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K

    Journal of Alzheimer's disease : JAD   68 ( 4 )   1667 - 1675   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-181218

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  • Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.

    Nomura E, Nakano Y, Takahashi Y, Takemoto M, Yamashita T, Ueno S, Wakutani Y, Takao Y, Morimoto N, Kutoku Y, Sunada Y, Taomoto K, Manabe Y, Deguchi K, Higashi Y, Inufusa H, You F, Yoshikawa T, von Greiffenclau MM, Abe K

    J Alzheimers Dis   71 ( 3 )   1063 - 1069   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-190644

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  • A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy.

    Sasaki R, Ohta Y, Takahashi Y, Tsunoda K, Tadokoro K, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Abe K

    Internal medicine (Tokyo, Japan)   58 ( 3 )   437 - 440   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1048-18

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  • Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service.

    Ohta Y, Hishikawa N, Sato K, Takemoto M, Yamashita T, Doutare S, Abe K

    Internal medicine (Tokyo, Japan)   58 ( 8 )   1081 - 1085   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1554-18

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  • Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma.

    Ohta Y, Kawahara Y, Tadokoro K, Sato K, Sasaki R, Takahashi Y, Takemoto M, Hishikawa N, Yamashita T, Asano T, Inomata T, Abe K

    Internal medicine (Tokyo, Japan)   58 ( 2 )   283 - 286   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1269-18

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  • 一般住民健診における不眠症と認知・情動機能障害の特徴

    菱川 望, 福井 裕介, 武本 麻美, 商 敬偉, 佐藤 恒太, 太田 康之, 山下 徹, 阿部 康二

    臨床神経学   58 ( Suppl. )   S299 - S299   2018年12月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • Neuroprotective effects of SMTP-44D in mice stroke model in relation to neurovascular unit and trophic coupling.

    Shi X, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Suzuki E, Hasumi K, Abe K

    J Neurosci Res   96 ( 12 )   1887 - 1899   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jnr.24326

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  • Cervical compressive myelopathy caused by malfunction of a programmable cerebrospinal fluid shunt valve. 査読

    Sato K, Yamashita T, Tsunoda K, Takemoto M, Hishikawa N, Shang J, Ohta Y, Kuwahara K, Yasuhara T, Date I, Abe K

    Interdiscip Neurosurg   14   183 - 185   2018年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.inat.2018.08.009

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  • Different clinicopathological features between Japanese siblings with facioscapulohumeral muscular dystrophy 2 with a novel nonsense SMCHD1 mutation (Arg552?).

    Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Takemoto M, Hishikawa N, Shang J, Yamashita T, Takehisa Y, Nishino I, Abe K

    J Clin Neurosci   58   215 - 217   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jocn.2018.10.021

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  • Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects.

    Huang Y, Ohta Y, Shang J, Li X, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K

    J Stroke Cerebrovasc Dis   27 ( 12 )   3521 - 3528   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.018

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  • Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Xianghong Li, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   27 ( 12 )   3521 - 3528   2018年12月

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    掲載種別:研究論文(学術雑誌)  

    © 2018 Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both thrombolytic and anti-inflammatory effects, but its neuroprotective effects on cerebral ischemia are still unclear. The present study assessed the antioxidative and neurovascular unit (NVU) protective effects of SMTP-7 using transient middle cerebral artery occlusion (tMCAO) mice. Methods: After 60 minutes tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA + SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the hemorrhage and expressive changes of antioxidative markers in brains. Results: SMTP-7 treatment showed a similar antithrombotic effect to tPA, but significantly decreased the hemorrhage volumes and the number of 4-HNE, 3-NT and 8-OHdG positive cells, meanwhile, ameliorated the decrease of collagen IV in the ischemic brains. However, tPA + SMTP-7 treatment did not decrease hemorrhage volumes nor showed NVU protective effect. Conclusions: The present study suggested that SMTP-7 provided therapeutic benefits for ischemic stroke through antioxidative and NVU protective effects unlike tPA alone or tPA + SMTP-7.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.018

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  • コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への影響

    太田 康之, 菱川 望, 山下 徹, 佐藤 恒太, 武本 麻美, 阿部 康二

    神経治療学   35 ( 6 )   S238 - S238   2018年11月

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  • A case of aspergillotic orbital apex syndrome diagnosed by an additional intraorbital biopsy after nasal endoscopy. 査読

    Matsumoto N, Sato K, Tadokoro K, Takahashi Y, Yunoki T, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Fujii K, Ichikawa T, Date I, Abe K

    Neurol Clin Neurosci   6 ( 6 )   188 - 190   2018年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12226

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  • Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice.

    Huang Y, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K

    J Stroke Cerebrovasc Dis   27 ( 11 )   3084 - 3094   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.039

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  • Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   27 ( 11 )   3084 - 3094   2018年11月

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    掲載種別:研究論文(学術雑誌)  

    © 2018 Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both potentials of thrombolytic and neuroprotective effects, but its detailed neuroprotective mechanisms in ischemic stroke are still unclear. Here, we assessed the neuroprotective effects of SMTP-7 for anti-inflammatory and antiapoptosis mechanisms after 60 minutes of transient middle cerebral artery occlusion (tMCAO) in mice. Methods: After 60 minutes of tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA+SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the antineuroinflammatory effect of SMTP-7 on the expressive changes of inflammatory markers in ischemic mouse brains. Results: Compared with the vehicle and tPA groups, SMTP-7 treatment significantly improved clinical scores and decreased the infarct volume and the numbers of TNF-α, nuclear factor-κB (NF-κB), nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3), and cleaved caspase-3-positive cells in the brain of mice at 24 hours after tMCAO but not p62-positive cells. However, tPA+SMTP-7 treatment did not show such effects. Conclusions: The present study suggested that SMTP-7 provides a therapeutic benefit for ischemic stroke mice through anti-inflammatory and antiapoptotic effects but not antiautophagic effect.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.039

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  • マウス脳梗塞モデルにおける新規抗酸化サプリメントTwendeeXの脳保護効果

    中野 由美子, 草木 桃子, 太田 康之, 山下 徹, 犬房 春彦, 森原 隆太, 商 敬偉, 佐藤 恒太, 武本 麻美, 菱川 望, 阿部 康二

    脳循環代謝   30 ( 1 )   140 - 140   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • Affective improvement of neurological disease patients and caregivers using an automated telephone call service

    Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Mami Takemoto, Shinji Doutare, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   56   74 - 78   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Neurological disease patients living alone or with a single caregiver need a support system to care for their psychological symptoms. We evaluated the clinical effects of a unique telephone call system that automatically called participants at their desired times once a week for 3 months. In total, 104 neurological disease patients and caregivers were evaluated by the geriatric depression scale, apathy scale and state and trait anxiety inventories (STAI) forms X-I for depression, apathy and state anxiety, respectively. High baseline STAI scores (40 >=) significantly improved in the Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and spinocerebellar degeneration (SCD) + multiple system atrophy (MSA) patients (p = 0.001, p = 0.013 and p = 0.046, respectively) after patients/caregivers used the telephone call service. The baseline (pre) STAI score significantly correlated with the score change (post-pre) in PD, ALS, SCD + MSA, Alzheimer' s disease patients (ADp), and caregivers for ADp (p < 0.0001, p = 0.001, p = 0.011, p = 0.025 and p = 0.020, respectively). The geriatric depression scale and apathy scale did not significantly improve. The present study suggests that there is a positive effect of using an automated telephone call service for anxiety in neurological disease patients and caregivers, especially in ALS, SCD + MSA and PD patients with high STAI scores (40 >=). (C) 2018 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2018.07.006

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  • コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への治療効果

    太田 康之, 菱川 望, 山下 徹, 佐藤 恒太, 武本 麻美, 阿部 康二

    Dementia Japan   32 ( 3 )   473 - 473   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

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  • Rare valiant vertical one-and-a-half syndrome without ipsilateral upward gaze palsy in a patient with thalamomesencephalic stroke.

    Sato K, Takahashi Y, Matsumoto N, Yunoki T, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

    Neurol Clin Neurosci   6 ( 5 )   133 - 135   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12210

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  • Vogt?Koyanagi?Harada case accompanied by polyneuropathy. 査読

    Tsunoda K, Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Nomura E, Takemoto M, Hishikawa N, Yamashita T, Kajita A, Abe K

    Neurol Clin Neurosci   6 ( 5 )   138 - 140   2018年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12213

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  • Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain.

    Shang J, Yan H, Jiao Y, Ohta Y, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K

    J Stroke Cerebrovasc Dis   27 ( 8 )   2096 - 2105   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.012

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  • Detecting spinal spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography

    Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROSCIENCE RESEARCH   133   58 - 63   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5. The fractional anisotropy (FA) values of ALS-total and ALS-limb patients were significantly reduced compared with normal controls, and SBMA patients. On the other hand, the mean diffusivity (MD) values were not significantly different among normal controls and the three disease groups. The rate of disease progression (Delta FRS-R) of ALS patients was significantly correlated with FA values and central motor conduction time (CMCT). In conclusion, the present study demonstrated a significant reduction of FA values in ALS patients, and the Delta FRS-R of ALS patients showed distinct regressions with FA values and CMCT, suggesting that this DTT analysis could be useful for detecting disease progression of ALS patients. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

    DOI: 10.1016/j.neures.2017.11.005

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  • Detecting spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography 査読

    Yusuke Fukui,Nozomi Hishikawa*,Kota Sato*,Yumiko Nakano,Ryuta Morihara,Jingwei Shang*,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

    Neuroscience Research   133   58 - 63   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neures.2017.11.005

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  • Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model.

    Jiao Y, Shang J, Ohta Y, Yan H, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K

    J Stroke Cerebrovasc Dis   27 ( 8 )   2166 - 2174   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.014

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  • A unique telephone support system for dementia patients and their caregivers managed in Japan (Okayama Dementia Call Center, ODCC). 査読

    Nakano Y, Hishikawa N, Sakamoto K, Myoraku Y, Ozaki Y, Takemoto M, Sato K, Yamashita T, Ohta Y, Abe K

    Neurol Clin Neurosci   6 ( 4 )   100 - 103   2018年7月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12200

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  • Fulminant Guillain-Barre syndrome with Takotsubo cardiomyopathy: Report of an autopsied case. 査読

    Takemoto M, Yamashita T, Ohta Y, Hishikawa N, Sato K, Tsunoda K, Shang J, Deguchi K, Tanaka T, Nishimura H, Furutani M, Abe K

    Neurol Clin Neurosci   6 ( 4 )   117 - 119   2018年7月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12197

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  • Clinical predictors of Alzheimer's disease progression.

    Hishikawa N, Fukui Y, Takemoto M, Sato K, Shang J, Yamashita T, Ohta Y, Abe K

    Geriatr Gerontol Int   18 ( 6 )   929 - 936   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ggi.13286

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  • Clinical predictors of Alzheimer's disease progression

    Nozomi Hishikawa, Yusuke Fukui, Mami Takemoto, Kota Sato, Jingwei Shang, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    Geriatrics and Gerontology International   18 ( 6 )   929 - 936   2018年6月

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    掲載種別:研究論文(学術雑誌)  

    © 2018 Japan Geriatrics Society Aim: Rates of disease progression differ among patients with Alzheimer's disease (AD), but prognostic predictions remain a challenge. We carried out a clinic-based retrospective study to investigate the clinical factors for AD progression. Methods: The 748 AD patients, who attended our hospital for >1 year and were given the Mini-Mental State Examination (MMSE) at least three times, were divided into three groups according to the annual change rate of MMSE score (G): Aggravater group (G < −2), Stabler group (−2 ≤ G ≤ 2) and Improver group (2 < G). We compared the three groups on cognitive, affective and activities of daily living functions, response to medication, clinical fluctuations, serum levels of metabolic factors, and neuroimaging data. Results: We found no significant differences in age, sex, educational attainment or body mass index across the groups. The Aggravater group showed better baseline MMSE (P < 0.01) and Abe's behavioral and psychological symptoms of dementia (P < 0.01) scores than the Improver group, but its MMSE improvement after drug treatment was the worst among the three groups (P < 0.01 vs Stabler/Improver). Fluctuations in MMSE (P < 0.01), apathy scale (P < 0.05) and activities of daily living (P < 0.01) scores were smaller in the Improver group than in the Aggravater or Stabler groups. Serum docosahexaenoic acid levels tended to be lower (trend P < 0.05) and voxel-based specific regional analysis system for Alzheimer's disease Z-scores tended to be higher (trend P < 0.05) in the Improver group than in the Stabler or Aggravater groups. Conclusions: Initial responses to medication, fluctuations in cognitive, affective and activities of daily living functions, serum docosahexaenoic acid levels, and medial temporal atrophy are clinical factors related to AD prognosis. Geriatr Gerontol Int 2018; 18: 929–936.

    DOI: 10.1111/ggi.13286

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  • A case of bilateral internal carotid artery dissection in young adult with cranial nerve IX and X palsies. 査読

    Sasaki R, Yamashita T, Takahashi Y, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Neurol Clin Neurosci   6 ( 3 )   80 - 82   2018年5月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12187

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  • Case of acromegalic myopathy and arthropathy long after trans‐sphenoidal surgery. 査読

    Sasaki R, Yamashita T, Takahashi Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

    Neurol Clin Neurosci   6 ( 3 )   77 - 79   2018年5月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ncn3.12191

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  • Case of congenital fibrosis of the extraocular muscles type 1 with progressive cerebellar ataxia

    Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Emi Nomura, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 2 )   48 - 50   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    A 70-year-old women presented classical CEFOM1 phenotypes such as bilateral ptosis and external ophthalmoplegia, but also progressive cerebellar ataxia, carrying a previously reported heterozygous missense mutation of KIF21A p.Arg941Gln. The present case is the first report of CFEOM1 showing cerebellar atrophy with hypoperfusion, mainly of the vermis, indicating that cerebellar function should be carefully evaluated in CFFOM1 patients.

    DOI: 10.1111/ncn3.12178

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  • Emergency ventricular drainage plus systemic antibiotics saved an elderly patient with intraventricular rupture as a result of a pituitary abscess

    Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 1 )   13 - 15   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    A pituitary abscess is a rare intracranial infection, and direct transsphenoidal surgery is common for the therapy. Intracranial rupture of the pituitary abscess is usually fatal. Here, we report a 76-year-old woman with a pituitary abscess who showed headaches, left eyelid ptosis, periorbital swelling and external eye movement disturbances in the left eye. Although her symptoms initially improved after therapy with systemic antibiotics, the pituitary abscess suddenly developed an intraventricular rupture on admission day 27. However, emergency ventricular drainage in combination with different antibiotics gradually improved her condition. The present case suggests that the combination of emergency ventricular drainage and systemic antibiotic administration could serve as an alternative choice to manage pituitary abscesses of ventricular ruptures, especially in elderly patients.

    DOI: 10.1111/ncn3.12167

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  • A Japanese Encephalitis Patient Presenting with Parkinsonism with Corresponding Laterality of Magnetic Resonance and Dopamine Transporter Imaging Findings.

    Tadokoro K, Ohta Y, Sato K, Maeki T, Sasaki R, Takahashi Y, Shang J, Takemoto M, Hishikawa N, Yamashita T, Lim CK, Tajima S, Abe K

    Intern Med   57 ( 15 )   2243 - 2246   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.0337-17

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  • Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy.

    Sasaki R, Ohta Y, Yamada Y, Tadokoro K, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Yasuhara T, Date I, Ikegawa S, Fujii N, Abe K

    Intern Med   57 ( 23 )   3463 - 3465   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1049-18

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  • A unique case of hemi-tongue pseudohypertrophy, necrotizing myopathy, and erythema nodosum.

    Sato K, Takahashi Y, Yamashita T, Takemoto M, Hishikawa N, Jinwei S, Ohta Y, Abe K

    Neurol Int   10 ( 4 )   95 - 96   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4081/ni.2018.7852

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  • A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications.

    Hishikawa N, Fukui Y, Sato K, Takemoto M, Yamashita T, Ohta Y, Abe K

    Intern Med   57 ( 16 )   2399 - 2402   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.9454-17

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  • A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications

    Nozomi Flishikawa, Yusuke Fukui, Kota Sato, Mami Takemoto, Tom Yamashita, Yasuyuki Ohta, Koji Abe

    INTERNAL MEDICINE   57 ( 16 )   2399 - 2402   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    The authors report a man who developed oral dyskinesia at 46 years of age, followed by slowly progressive choreic movement and mild cognitive impairment over 20 years. He showed caudate atrophy and four types of intracranial calcification in the hippocampus (dot-like), cerebellar white matter (vague-mass), occipital cortices (laminar), and cerebral white matter (linear). Linear-calcification in the corona radiata seems to be deposition along small veins, which may be related to the white matter changes and to the decreased regional cerebral blood flow in the frontal and parietal lobes. The present case shows a slowly progressive disease with caudate atrophy and characteristic brain calcifications.

    DOI: 10.2169/internalmedicine.9454-17

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  • PDDとDLBの認知機能、情動機能、脳血流分布の比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    Anti-aging Science   9 ( 2 )   109 - 109   2017年12月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • メタボリック症候群を伴うアルツハイマー病の特徴

    菱川 望, 福井 裕介, 武本 麻美, 佐藤 恒太, 太田 康之, 山下 徹, 阿部 康二

    Anti-aging Science   9 ( 2 )   111 - 111   2017年12月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • 大脳白質病変を伴うアルツハイマー病患者における抗認知症薬の臨床的効果

    福井 裕介, 菱川 望, 佐藤 恒太, 中野 由美子, 森原 隆太, 武本 麻美, 商 敬偉, 太田 康之, 山下 徹, 阿部 康二

    Anti-aging Science   9 ( 2 )   110 - 110   2017年12月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease 査読

    Keiichiro Tsunoda,Toru Yamashita*,Hitoshi Shimada,Emi Nomura,Yoshiaki Takahashi,Jingwei Shang*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Makoto Higuchi,Tetsuya Suhara,Yasumasa Kokubo,Shigeki Kuzuhara,Koji Abe*

    Journal of Clinical Neuroscience   46   64 - 67   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jocn.2017.08.057

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  • Japanese sibling cases of multiple sclerosis presenting with different clinical phenotypes

    Kota Sato, Yasuyuki Ohta, Toru Yamashita, Keiichiro Tsunoda, Kentaro Deguchi, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   186 - 188   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Unlike in Western countries, only a few familial multiple sclerosis cases have been reported from Asian countries. Herein, we report on the characteristics of siblings with multiple sclerosis. Their parents were consanguineous, and the siblings showed different first symptoms of gait disturbance or double vision, with a clinical phenotype of primary progressive multiple sclerosis or relapse-remitting multiple sclerosis. Their human leukocyte antigen showed unique subtypes of DPB1 (0501/0901 or 0901/0901) and DRB1 (0406/1502 or 1502/1502).

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  • Serious hyponatremia induced by a combination of angiotensin II receptor blocker and thiazide caused deterioration of cognitive functions and psychological symptoms in an elderly Alzheimer's disease patient

    Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   192 - 194   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    As the number of elderly people increases, Alzheimer's disease and hypertension have become more common. This is an important case report that shows severe hyponatremia induced by a combination of angiotensin II receptor blocker and thiazide, causing the deterioration of cognitive functions in an elderly patient. In rapidly aging societies around the world, more attention should be paid to hyponatremia under combination therapy of angiotensin II receptor blocker plus thiazide to assist elderly patients.

    DOI: 10.1111/ncn3.12161

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  • Type 2 Alexander disease with a novel glial fibrillary acidic protein gene mutation and its unique clinical features

    Yuko Kawahara, Toru Yamashita, Yasuyuki Ohta, Kota Sato, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Jingwei Shang, Tomokatsu Yoshida, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   183 - 185   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We report mother-daughter cases of type 2 Alexander disease with a novel glial fibrillary acidic protein gene mutation. The mother (proband) began to show slowly progressive gait disturbance. However, after an incidental medical checkup, it took just 9 months for the diagnosis. Different from the previous reports, she showed a unique phenotype in points of scoliosis without palatal myoclonus, decreased regional cerebral blood flow in the frontal lobe and mild cognitive impairment. Her second daughter showed mild intellectual disability. Genetic analysis of the mother and the second daughter showed the same novel glial fibrillary acidic protein gene mutation (c.371_372insAGA).

    DOI: 10.1111/ncn3.12146

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  • Therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with Alzheimer's disease 査読

    Yasuyuki Ohta*,Mohamed Darwish,Nozomi Hishikawa*,Toru Yamashita*,Kota Sato*,Mami Takemoto*,Koji Abe*

    Geriatrics and Gerontology International   17 ( 11 )   1843 - 1848   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ggi.12971

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  • 緊急脳室ドレナージと全身抗生剤投与にて救命しえた下垂体部膿瘍から脳室穿破に伸展した一例

    高橋 義秋, 山下 徹, 佐々木 諒, 田所 功, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    臨床神経学   57 ( 10 )   651 - 651   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本神経学会  

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  • Behavioral and affective features of amyotrophic lateral sclerosis patients 査読

    Yasuyuki Ohta*,Kota Sato*,Mami Takemoto*,Yoshiaki Takahashi,Ryuta Morihara,Yumiko Nakano,Keiichiro Tsunoda,Emi Nomura,Nozomi Hishikawa*,Toru Yamashita*,Koji Abe*

    Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences   381   119 - 125   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2017.08.024

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  • 新しいSCA/ALS crossroad mutation AsidanのDWEP現象

    太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 角田 慶一郎, 武本 麻美, 菱川 望, 阿部 康二

    日本難病医療ネットワーク学会機関誌   5 ( 1 )   59 - 59   2017年9月

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    記述言語:日本語   出版者・発行元:日本難病医療ネットワーク学会  

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  • Non-ketotic hyperosmolar coma after percutaneous endoscopic gastrostomy in an advanced stage of progressive supranuclear palsy

    Koh Tadokoro, Kota Sato, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   162 - 164   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Patients with progressive supranuclear palsy often suffer from dysphagia, and percutaneous endoscopic gastrostomy is a treatment option for the advanced stage of this disease. The present percutaneous endoscopic gastrostomy patient had slightly impaired glucose tolerance, but the condition became considerably worse with normal nutrients due to limited activity and an infection after percutaneous endoscopic gastrostomy, resulting in a non-ketotic hyperosmolar coma. After receiving supplementary fluid, intravenous insulin, antibiotics and endotracheal intubation, the patient recovered from the non-ketotic hyperosmolar coma state. Percutaneous endoscopic gastrostomy placement at an advanced stage of a neurodegenerative disorder, such as progressive supranuclear palsy, should have a careful follow-up, especially when glucose tolerance worsens.

    DOI: 10.1111/ncn3.12139

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  • Occult chronic progressive cervical and thoracic myelopathy without evident magnetic resonance imaging lesion

    Emi Nomura, Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Hiroki Ueno, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   155 - 158   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Progressive myelopathy is caused by infectious, inflammatory, autoimmune, paraneoplastic, demyelinating, vascular, hereditary, degenerative, metabolic and toxic properties. Here, we report a case of a 53-year-old woman who showed a progressive cervical and thoracic myelopathy with muscle weakness in all limbs, and hypoesthesia in all limbs and trunk below the Th8 level without any evident magnetic resonance imaging lesions. She displayed rheumatoid factor, anti-double stranded DNA antibody and hepatitis B surface antigen, as well as an elevated cerebrospinal fluid protein level. The paraneoplastic antibodies that we examined were negative. Our treatments (plasma exchange, steroid pulse therapy and immunoglobulin therapy) were slightly effective, but the symptoms did not improve completely. The present case suggests that the presence of a cervical and thoracic lesion without evident magnetic resonance imaging abnormalities required a careful follow up to discover occult lesions.

    DOI: 10.1111/ncn3.12136

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  • Case of myasthenia gravis and Lambert-Eaton myasthenic syndrome overlap syndrome accompanied by autoimmune encephalitis and cerebellar ataxia with multiple neuronal antibodies

    Yumiko Nakano, Emi Nomura, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   152 - 154   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    A 72-year-old woman developed a subacute series of encephalitis, cerebellar ataxia, and combined symptoms of both myasthenia gravis and Lambert-Eaton myasthenic syndrome. Seven different neuronal antibodies were detected for Hu, glutamic acid decarboxylase, acetylcholine receptor, P/Q-type voltage-gated calcium-channels, Zic4, Titin and SOX1 in her serum with intrathecal synthesis of glutamic acid decarboxylase antibodies. Although she showed classical manifestations with onconeural antibodies, she was diagnosed with not paraneoplastic but autoimmune neurological syndrome because of no underlying tumor and good response to immunotherapies. The present case is very unique and rare for complex neurological disorders including myasthenia gravis and Lambert-Eaton myasthenic syndrome overlap syndrome with multiple neuronal antibodies.

    DOI: 10.1111/ncn3.12134

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  • Dissociated recovery between dementia and parkinsonism by transvenous embolization of recurrent dural arteriovenous fistula

    Yumiko Nakano, Emi Nomura, Masafumi Hiramatsu, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Kenji Sugiu, Isao Date, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   159 - 161   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Dementia and parkinsonism are rarely observed in dural arteriovenous fistula. Here, we report a case of a 63-year-old man with recurrent dural arteriovenous fistula, who developed progressive dementia and parkinsonism as a result of a dural arteriovenous fistula at the torcular herophili. A sinus thrombosis induced the abnormal cortical venous reflux from the isolated straight sinus, resulting in the deep venous congestion of the thalamus and basal ganglia, which led to dementia and parkinsonism. However, the third endovascular embolization ameliorated memory disturbance and apathy with a slight improvement of parkinsonism. Although recoveries from dural arteriovenous fistula-associated neurological deficits are variable depending on the severity, duration and, furthermore, selective vulnerability of the responsible ischemic lesions, early treatment should be essential for better recovery.

    DOI: 10.1111/ncn3.12138

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  • Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model 査読

    Momoko Kusaki,Yasuyuki Ohta*,Haruhiko Inufusa,Toru Yamashita*,Ryuta Morihara,Yumiko Nakano,Xia Liu,Jingwei Shang*,Feng Tian,Yusuke Fukui,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Koji Abe*

    Journal of Stroke and Cerebrovascular Diseases   26 ( 6 )   1191 - 1196   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2017.01.003

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  • Different Characteristics of Anterior and Posterior Branch Atheromatous Diseases with or without Early Neurologic Deterioration 査読

    Yoshiaki Takahashi,Toru Yamashita*,Ryuta Morihara,Yumiko Nakano,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Yasuhiro Manabe,Koji Abe*

    Journal of Stroke and Cerebrovascular Diseases   26 ( 6 )   1314 - 1320   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.001

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  • Factors related to continuous and discontinuous attendance at memory clinics 査読

    N. Hishikawa *,Y. Fukui ,Y. Nakano ,R. Morihara ,M. Takemoto *,K. Sato *,T. Yamashita *,Y. Ohta *,K. Abe *

    European Journal of Neurology   24 ( 5 )   673 - 679   2017年5月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ene.13268

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  • Familial amyotrophic lateral sclerosis of the G37V-superoxide dismutase 1 mutation with a slow disease progression

    Koh Tadokoro, Yasuyuki Ohta, Yoshiaki Takahashi, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 3 )   96 - 98   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    The majority of amyotrophic lateral sclerosis patients have the sporadic form, but 5-10% of those have familial amyotrophic lateral sclerosis. A total of 15-20% of familial amyotrophic lateral sclerosis patients have genetic mutations in the superoxide dismutase 1 gene. In 2012, Kobayashi et al. reported the first case of a familial amyotrophic lateral sclerosis patient carrying a G37V superoxide dismutase 1 mutation, who showed rapid progression and died within 1.2 years of onset from respiratory failure. In contrast, here we report the second case of familial amyotrophic lateral sclerosis carrying the G37V superoxide dismutase 1 mutation, showing a very slow progression, and his father and aunt also had longer disease durations from 4 to 6 years. Further clinical and biological studies will clarify the detailed pathological role of the G37V superoxide dismutase 1 mutation for amyotrophic lateral sclerosis.

    DOI: 10.1111/ncn3.12123

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  • Ataxic form of autosomal recessive PEX10-related peroxisome biogenesis disorders with a novel compound heterozygous gene mutation and characteristic clinical phenotype 査読

    Toru Yamashita*,Jun Mitsui,Nobuyuki Shimozawa,Shigeo Takashima,Hiroshi Umemura*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Takashi Matsukawa,Hiroyuki Ishiura,Jun Yoshimura,Koichiro Doi,Shinichi Morishita,Shoji Tsuji,Koji Abe*

    Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences   375   424 - 429   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2017.02.058

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  • Potential multisystem degeneration in Asidan patients 査読

    Yasuyuki Ohta*,Toru Yamashita*,Nozomi Hishikawa*,Kota Sato*,Kosuke Matsuzono,Keiichiro Tsunoda,Noriko Hatanaka,Mami Takemoto*,Toshihiko Takemi,Kazuhiro Takamatsu,Koji Abe*

    Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences   373   216 - 222   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2017.01.003

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  • Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with limbic encephalitis 査読

    Yasuyuki Ohta*,Emi Nomura,Keiichiro Tsunoda,Toru Yamashita*,Yoshiaki Takahashi,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Koji Abe*

    Internal Medicine, Japanese Journal of Medicine, Internal medicine (Tokyo, Japan)   56 ( 18 )   2513 - 2518   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.8533-16

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  • Emergency caesarean section saved both an anti-musk antibody-positive myasthenia gravis mother with pregnancy-induced hypertension and her premature baby

    Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Kei Hayata, Hisashi Masuyama, Tomoka Okamura, Yosuke Washio, Koji Abe

    Internal Medicine   56 ( 24 )   3361 - 3364   2017年

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    掲載種別:研究論文(学術雑誌)  

    © 2017 The Japanese Society of Internal Medicine. We herein report the case of a 46-year-old pregnant woman with anti-muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) who showed pregnancy-induced hypertension and developed respiratory failure at 30 weeks and 5 days of pregnancy, and who underwent an emergency caesarean section (CS). Her MG symptoms gradually improved in the subsequent weeks. The premature baby with positive MuSK antibodies was successfully delivered, but the male baby required temporary artificial ventilation. However, his condition also gradually improved over time. The present case suggests that an emergency CS could rescue both the mother, who was in critical condition, and the prematurely born baby, even when suffering from acute respiratory insufficiency.

    DOI: 10.2169/internalmedicine.8636-16

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  • 脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

    山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 太田 康之, 阿部 康二

    Anti-aging Science   8 ( 1 )   72 - 72   2016年12月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • アルツハイマー病患者におけるガランタミンの長期的効果について

    中野 由美子, 山下 徹, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    Anti-aging Science   8 ( 1 )   69 - 69   2016年12月

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    記述言語:日本語   出版者・発行元:(株)メディカルレビュー社  

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  • 難病患者就労に対する山陽神経難病ネットワークの役割

    太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 阿部 康二, 三宅 進, 重實 比呂子, 三村 あゆみ, 三垣 亮輔, 竹内 秀将, 岩藤 弘子, 薮田 智子, 斎藤 文恵, 鈴木 美穂, 竹内 ひかり

    日本難病医療ネットワーク学会機関誌   4 ( 1 )   61 - 61   2016年11月

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    記述言語:日本語   出版者・発行元:日本難病医療ネットワーク学会  

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  • ラット一過性脳虚血モデルにおけるTDP43とFUS/TLSの発現亢進による神経細胞保護効果について

    中野 由美子, Sun Miao, 山下 徹, 森原 隆太, 武本 麻美, 佐藤 恒太, 菱川 望, 太田 康之, 阿部 康二

    脳循環代謝   28 ( 1 )   232 - 232   2016年11月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • PDDとDLB患者の認知機能・情動機能・日常生活活動強度の比較

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10回   88 - 88   2016年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • 多発脳神経麻痺が急速に進行した腎癌の頭蓋底転移の1剖検例

    武本 麻美, 河原 由子, 佐藤 恒太, 佐藤 康晴, 太田 康之, 菱川 望, 山下 徹, 阿部 康二

    日本老年医学会雑誌   53 ( 4 )   461 - 461   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • Asidan(ALS/SCA crossroad mutation)はSWEDDsと正反対所見DWEPを呈する

    阿部 康二, 太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10回   84 - 84   2016年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain 査読

    Qian Li,Yumiko Nakano,Jingwei Shang,Yasuyuki Ohta*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Toru Yamashita*,Koji Abe*

    Journal of Stroke and Cerebrovascular Diseases   25 ( 10 )   2344 - 2351   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2016.05.031

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  • Differences between the behavioral and psychological symptoms of Alzheimer's disease and Parkinson's disease 査読

    Ryo Tokuchi,Nozomi Hishikawa*,Kota Sato*,Noriko Hatanaka,Yusuke Fukui,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

    Journal of the Neurological Sciences, World neurology   369   278 - 282   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2016.08.053

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  • Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease 査読

    Noriko Hatanaka,Kota Sato*,Nozomi Hishikawa*,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

    European Neurology   75 ( 5-6 )   282 - 289   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000445111

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  • 脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

    山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 太田 康之, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   16回   191 - 191   2016年6月

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    記述言語:日本語   出版者・発行元:(一社)日本抗加齢医学会  

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  • Age-dependent cognitive and affective differences in Alzheimer's and Parkinson's diseases in relation to MRI findings 査読

    Ryo Tokuchi,Nozomi Hishikawa*,Kota Sato*,Noriko Hatanaka,Yusuke Fukui,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

    Journal of the Neurological Sciences, World neurology   365   3 - 8   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jns.2016.03.031

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  • New susceptible variant of COQ2 gene in Japanese patients with sporadic multiple system atrophy

    Zhuoran Sun, Yasuyuki Ohta, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    Neurology: Genetics   2 ( 2 )   2016年4月

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    掲載種別:研究論文(学術雑誌)  

    © 2016 American Academy of Neurology. Objective: The aim of this study was to analyze the association between the variations of coenzyme Q2 4-hydroxybenzoate polyprenyltransferase gene (COQ2) and Japanese patients with multiple system atrophy (MSA). Methods: We investigated the genetic variations in exons 1, 2, 6, and 7 of the COQ2 gene in 133 Japanese patients with MSA and 200 controls and analyzed the association between the variations and MSA. Results: Six DNA variations (G21S, L25V, V66L, P157S, V393A, and X422K) were found in the 133 patients with MSA, and G21S and X422K were new variations that had never been reported. V66L was a common variation that was found in all 133 patients with MSA. G21S, P157S, V393A, and X422K did not show gene frequency differences between patients with MSA and controls. On the other hand, L25V was newly proven to be the only risk factor of sporadic MSA with predominant olivopontocerebellar ataxia. Conclusions: The present study suggests L25V variant of COQ2 gene as a genetic risk factor in Japanese patients with MSA with cerebellar ataxia.

    DOI: 10.1212/NXG.0000000000000054

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  • Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease

    Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    EUROPEAN NEUROLOGY   75 ( 5-6 )   282 - 289   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000445111

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  • Different Clinical and Neuroimaging Characteristics in Early Stage Parkinson's Disease with Dementia and Dementia with Lewy Bodies 査読

    Mami Takemoto*,Kota Sato*,Noriko Hatanaka,Toru Yamashita*,Yasuyuki Ohta*,Nozomi Hishikawa*,Koji Abe*

    Journal of Alzheimer's Disease   52 ( 1 )   205 - 211   2016年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3233/JAD-150952

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  • 多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の有用性

    太田 康之, 河原 由子, 薮田 智子, 竹内 ひかり, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   3 ( 1 )   55 - 55   2015年11月

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    記述言語:日本語   出版者・発行元:日本難病医療ネットワーク学会  

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  • 脳卒中慢性期患者では再発よりも認知症移行(direct conversion)が高い

    中野 由美子, 出口 健太郎, 山下 徹, 武本 麻美, 佐藤 恒太, 菱川 望, 太田 康之, 高尾 芳樹, 東 靖人, 阿部 康二

    脳循環代謝   27 ( 1 )   149 - 149   2015年10月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • 進行性核上性麻痺・パーキンソン病患者における歩行の比較

    幡中 典子, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   9回   81 - 81   2015年10月

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    記述言語:日本語   出版者・発行元:Movement Disorder Society of Japan (MDSJ)  

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  • テルミサルタン長期投与がラット梗塞後脳に及ぼすメタボリックシンドローム関連因子発現の検討

    出口 健太郎, ざい 蘊, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    脳循環代謝   27 ( 1 )   195 - 195   2015年10月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • 多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の検討

    太田 康之, 河原 由子, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    Dementia Japan   29 ( 3 )   404 - 404   2015年9月

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    記述言語:日本語   出版者・発行元:(一社)日本認知症学会  

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  • PDDとDLBの認知機能、情動機能の比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    日本神経心理学会総会プログラム・予稿集   39回   204 - 204   2015年8月

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    記述言語:日本語   出版者・発行元:日本神経心理学会  

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  • MCIの予後と関連因子の検討

    徳地 亮, 菱川 望, 佐藤 恒太, 幡中 典子, 武本 麻美, 福井 裕介, 太田 康之, 山下 徹, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   15回   190 - 190   2015年5月

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    記述言語:日本語   出版者・発行元:(一社)日本抗加齢医学会  

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  • タッチパネル式コンピュータを活用した脳梗塞既往患者の認知機能と画像所見の関連の検討

    出口 健太郎, 河野 祥一郎, 柚木 太淳, 松薗 構佑, 中野 由美子, 角田 慶一郎, 河原 由子, 幡中 典子, 武本 麻美, 太田 康之, 菱川 望, 山下 徹, 阿部 康二

    脳循環代謝   26 ( 1 )   168 - 168   2014年11月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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  • 側頭葉内側萎縮と大脳白質病変の併存がアルツハイマー病患者の認知機能と情動機能に及ぼす影響

    徳地 亮, 菱川 望, 佐藤 恒太, 幡中 典子, 武本 麻美, 福井 裕介, 太田 康之, 出口 健太郎, 山下 徹, 阿部 康二

    脳循環代謝   26 ( 1 )   214 - 214   2014年11月

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    記述言語:日本語   出版者・発行元:(一社)日本脳循環代謝学会  

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書籍等出版物

  • 厚生労働科学研究補助金(難治性疾患克服研究事業)「運動失調症の医療基盤に関する調査研究」班平成29年度班会議(東京)

    阿部康二、山下徹、下澤伸行、佐藤恒太、武本麻美、菱川望、商敬偉、太田康之( 担当: 共著)

    厚生労働科学研究補助金(難治性疾患克服研究事業)「運動失調症の医療基盤に関する調査研究」班  2018年1月 

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    記述言語:日本語

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MISC

  • TTN missense variants in two siblings with asymmetric facial and limb weakness

    Ryo Sasaki, Yasuyuki Ohta, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Theerawat Kumutpongpanich, Ichizo Nishino, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   415   2020年8月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER  

    DOI: 10.1016/j.jns.2020.116885

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  • A novel homoplasmic mitochondrial DNA mutation (m.13376T > C, p.1347T) of MELAS presenting characteristic medial temporal lobe atrophy

    Ryo Sasaki, Yasuyuki Ohta, Noriko Hatanaka, Koh Tadokoro, Emi Nomura, Jingwei Shang, Mami Takemoto, Nozomi Hishikaw, Toru Yamashita, Yoshio Omote, Eisaku Morimoto, Sanae Teshigawara, Jun Wada, Yu-ichi Goto, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   408   2020年1月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER  

    DOI: 10.1016/j.jns.2019.116460

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  • 幹細胞移植による虚血脳のタンパク分解分子機構への影響

    田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

    神経治療学(Web)   37 ( 6 )   2020年

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  • 幹細胞移植による虚血脳のタンパク分解分子機構への影響

    田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

    脳循環代謝(Web)   32 ( 1 )   2020年

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  • DTTを用いた小脳遠心路・求心路の検討~多系統萎縮症と皮質性小脳萎縮症の比較~

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本脳神経CI学会総会プログラム・抄録集(Web)   43rd   2020年

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  • Tractographyを用いた筋萎縮性側索硬化症における頚髄側索錐体路の損傷評価

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本脳神経CI学会総会プログラム・抄録集(Web)   43rd   2020年

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  • トラクトグラフィーを用いたALSにおける頸髄側索錐体路の損傷評価

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本神経学会学術大会プログラム・抄録集   61st   2020年

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  • A unique Japanese CPEO family with a novel homozygous m.14819?T?>?G (p. S25A) substitution.

    Nomura E, Ohta Y, Tadokoro K, Sato K, Sasaki R, Takahashi Y, Yamashita T, Takemoto M, Hishikawa N, Goto YI, Abe K

    Journal of the neurological sciences   400   145 - 147   2019年5月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2019.03.029

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  • In Vivo Direct Reprogramming of Glial Linage to Mature Neurons in Post-stroke Brain

    Toru Yamashita, Jingwei Shang, Yumiko Nakano, Ryuta Morihara, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    CEREBROVASCULAR DISEASES   48   110 - 110   2019年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:KARGER  

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  • Congenital myopathy with fiber-type disproportion accompanied by dilated cardiomyopathy in a patient with a novel p.G48A ACTA1 mutation.

    Tadokoro K, Ohta Y, Sasaki R, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Nakamura K, Nishino I, Abe K

    J Neurol Sci   393   142 - 144   2018年10月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2018.08.015

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  • A new familial distal myopathy in Japan with predominant upper extremities. 査読

    Takahashi Y, Ohta Y, Sasaki R, Tadokoro K, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Nishino I, Abe K

    J Neurol Sci   390   205 - 207   2018年7月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2018.04.008

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  • Two cases of late onset familial amyloid polyneuropathy with a Glu61Lys transthyretin variant.

    Nakano Y, Tadokoro K, Ohta Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Yamashita T, Ando Y, Abe K

    J Neurol Sci   390   22 - 25   2018年7月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2018.04.003

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  • A mild myopathy with anti-SRP plus anti-PL-12 antibodies successfully treated by oral steroid monotherapy

    Koh Tadokoro, Yasuyuki Ohta, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Keigo Hayashi, Michiko Morishita, Ichizo Nishino, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   388   7 - 9   2018年5月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2018.02.040

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  • A novel presenilin 1 mutation (Leu418Trp) associated with spasticity, parkinsonism, and white matter lesion in a dominant Alzheimer's family

    Yoshiaki Takahashi, Yasuyuki Ohta, Ryo Sasaki, Kou Tadokoro, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takashi Haraguchi, Takeshi Ikeuchi, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   387   166 - 169   2018年4月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2018.01.006

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  • A patient with slowly progressive adult-onset nemaline myopathy and novel compound heterozygous mutations in the nebulin gene

    Keiichiro Tsunoda, Toru Yamashita, Emi Motokura, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Atsuko Nishikawa, Ichizo Nishino, Koji Abe

    Journal of the Neurological Sciences   373   254 - 257   2017年2月

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    掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.12.069

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  • A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis

    Kota Sato, Keiichiro Tsunoda, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toshiyuki Takahashi, Ichiro Nakashima, Takao Yasuhara, Isao Date, Koji Abe

    Journal of the Neurological Sciences   373   152 - 154   2017年2月

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    掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.12.040

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  • Marked hypertriglyceridemia induced by interferon-β1a therapy in a clinically isolated syndrome patient. 査読

    Kawahara Y, Yamashita T, Ohta Y, Sato K, Tsunoda K, Takemoto M, Hishikawa N, Eguchi J, Abe K

    J Neurol Sci.   373   144 - 146   2017年2月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.12.052

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  • An AOA2 patient with a novel compound heterozygous SETX frame shift mutations. 査読

    Motokura E, Yamashita T, Takahashi Y, Tsunoda K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Hashiguchi A, Takashima H, Abe K

    J Neurol Sci.   372   294 - 296   2017年1月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.11.074

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  • An autopsy case of intravascular large B-cell lymphoma with subcortical U-fiber sparing and unique lymphocyte markers 査読

    Kota Sato*,Emi Motokura,Kentaro Deguchi,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Toru Yamashita*,Junya Itakura,Koji Abe*

    Journal of the Neurological Sciences, World neurology   369   273 - 275   2016年10月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.08.051

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  • Different clinical features in siblings with identical mutations of the Parkin gene (PARK2) 査読

    Kota Sato*,Toru Yamashita*,Noriko Hatanaka,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Koji Abe*

    Journal of the Neurological Sciences, World neurology   368   147 - 149   2016年9月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.07.004

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  • Recurrent cervical internal carotid artery vasospasm relating to menstruation with endothelial dysfunction 査読

    Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

    Journal of the Neurological Sciences, World neurology   365   72 - 73   2016年6月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1016/j.jns.2016.03.044

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▼全件表示

 

担当授業科目

  • 社会医療疾病管理論 (2021年度) 後期  - その他