Updated on 2022/09/15

写真a

 
TAKEMOTO Mami
 
Organization
Okayama University Hospital Assistant Professor
Position
Assistant Professor
External link

Degree

  • Doctor of Medicine ( 2016.3   Kawasaki Medical School )

  • 博士(医学) ( 2004.3   川崎医科大学 )

Research Interests

  • Apathy

  • Dementia

  • Parkinson’s disease

Research Areas

  • Life Science / Neurology

Education

  • Kawasaki Medical School   医学部   大学院システム循環生理学(医用工学)

    2000.4 - 2004.3

      More details

    Country: Japan

  • Kawasaki Medical School    

    1990.4 - 1996.3

      More details

    Country: Japan

Research History

  • Okayama University   脳神経内科   Assistant Professor   Research associate

    2016.4

      More details

    Country:Japan

  • Okayama University   脳神経内科

    2013.4 - 2016.3

  • Kawasaki Medical School   胸部心臓血管外科   Research Assistant

    1998.4 - 2000.3

  • Kawasaki Medical School   外科

    1996.5 - 1998.3

Professional Memberships

  • 日本認知症予防学会

    2016.3

  • 日本老年医学会

    2013.4

  • 日本内科学会

    2013.4

  • 日本神経学会

    2013.4

  • 日本認知症学会

    2013.4

Committee Memberships

  • 日本内科学会中国支部   評議員  

    2020.11   

      More details

    Committee type:Academic society

    researchmap

 

Papers

  • A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation

    Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yumiko Nakano, Taijun Yunoki, Ryuta Morihara, Tatsuya Sasaki, Hiroyuki Akagawa, Koji Abe, Toru Yamashita

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2022.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be considered for surgical resection as treatment. Herein, we report a Japanese patient with a CCM2 mutation, c.609G>A (p.K203K) substitution, who showed drug-resistant epilepsy and dramatic improvement after surgical resection.

    DOI: 10.1111/ncn3.12649

    Web of Science

    researchmap

  • Clinical and Pathological Benefits of Scallop-Derived Plasmalogen in a Novel Mouse Model of Alzheimer's Disease with Chronic Cerebral Hypoperfusion. International journal

    Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian, Hongming Sun, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Ryuta Morihara, Koji Abe, Toru Yamashita

    Journal of Alzheimer's disease : JAD   2022.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The oral ingestion of scallop-derived plasmalogen (sPlas) significantly improved cognitive function in Alzheimer's disease (AD) patients. OBJECTIVE: However, the effects and mechanisms of sPlas on AD with chronic cerebral hypoperfusion (CCH), a class of mixed dementia contributing to 20-30% among the dementia society, were still elusive. METHODS: In the present study, we applied a novel mouse model of AD with CCH to investigate the potential effects of sPlas on AD with CCH. RESULTS: The present study demonstrated that sPlas significantly recovered cerebral blood flow, improved motor and cognitive deficits, reduced amyloid-β pathology, regulated neuroinflammation, ameliorated neural oxidative stress, and inhibited neuronal loss in AD with CCH mice at 12 M. CONCLUSION: These findings suggest that sPlas possesses clinical and pathological benefits for AD with CCH in the novel model mice. Furthermore, sPlas could have promising prevention and therapeutic effects on patients of AD with CCH.

    DOI: 10.3233/JAD-215246

    PubMed

    researchmap

  • Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models. International journal

    Ryuta Morihara, Toru Yamashita, Yosuke Osakada, Tian Feng, Xinran Hu, Yusuke Fukui, Koh Tadokoro, Mami Takemoto, Koji Abe

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   271678X221079127   2022.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The feasibility of transcranial sonothrombolysis has been demonstrated, although little is known about the relationships between thermal or mechanical mechanisms and thrombolytic outcomes. Therefore, the present study aims to reveal the effect and safety of temperature and ultrasound through in vitro and in vivo thrombolysis models. Artificial clots in microtubes were heated in a water bath or sonicated by ultrasound irradiation, and then clots weight decrease with rising temperature and sonication time was confirmed. In the in vitro thrombotic occlusion model, based on spot heating, clot volume was reduced and clots moved to the distal side, followed by recanalization of the occlusion. In the in vivo study, the common carotid artery of rats was exposed to a spot heater or to sonication. No brain infarct or brain blood barrier disruption was shown, but endothelial junctional dysintegrity and an inflammatory response in the carotid artery were detected. The present spot heating and ultrasound irradiation models seem to be effective for disintegrating clots in vitro, but the safety of the in vivo model was not fully supported by the data. However, the data indicates that a shorter time exposure could be less invasive than a longer exposure.

    DOI: 10.1177/0271678X221079127

    PubMed

    researchmap

  • Protective Effect of Rivaroxaban Against Amyloid Pathology and Neuroinflammation Through Inhibiting PAR-1 and PAR-2 in Alzheimer's Disease Mice. International journal

    Zhihong Bian, Xia Liu, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Ryuta Morihara, Koji Abe, Toru Yamashita

    Journal of Alzheimer's disease : JAD   86 ( 1 )   111 - 123   2022

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Recent studies have revealed that atrial fibrillation (AF) patients have a high risk of developing cognitive impairment, vascular dementia, and Alzheimer's disease (AD). Some reports suggest that the application of oral anticoagulant with an appropriate dose may have a preventive effect on AD. However, which oral anticoagulant drug is more appropriate for preventing AD and the underlying mechanism(s) is still unknown. OBJECTIVE: The aim of the present study was to assess the treatment effect of rivaroxaban administration as well as investigate the roles of PAR-1 and PAR-2 in the AD + CAA mice model. METHODS: In the present study, we compared a traditional oral anticoagulant, warfarin, and a direct oral anticoagulant (DOAC), rivaroxaban, via long-term administration to an AD with cerebral amyloid angiopathy (CAA) mice model. RESULTS: Rivaroxaban treatment attenuated neuroinflammation, blood-brain barrier dysfunction, memory deficits, and amyloid-β deposition through PAR-1/PAR-2 inhibition in the AD + CAA mice model compared with warfarin and no-treatment groups. CONCLUSION: The present study demonstrates that rivaroxaban can attenuate AD progress and can be a potential choice to prevent AD.

    DOI: 10.3233/JAD-215318

    PubMed

    researchmap

  • Chronic Beneficial Effect of Makeup Therapy on Cognitive Function of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. International journal

    Koh Tadokoro, Toru Yamashita, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Tomiko Tani, Koji Abe

    Journal of Alzheimer's disease : JAD   2021.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Makeup greatly impacts normal social lives but can also be a non-pharmacological form of therapy for dementia. OBJECTIVE: To evaluate the therapeutic effect of makeup therapy. METHODS: We carried out a prospective interventional study on female nursing home residents with dementia, focusing on the chronic therapeutic effect of makeup therapy. Thirty-four patients who received either only skin care (control group, n = 16) or skin care plus makeup therapy (makeup therapy group, n = 18) once every 2 weeks for 3 months were assessed. RESULTS: Three months of makeup therapy significantly improved the Mini-Mental State Examination (MMSE) score compared with control patients ( *p <  0.05). Artificial intelligence (AI) software revealed that the appearance of age decreased significantly in the makeup group compared with the control, especially among patients without depression ( *p <  0.05). Furthermore, a larger AI happiness score was significantly correlated with a greater improvement of ADL in the makeup therapy group (r = 0.43,  *p <  0.05). CONCLUSION: Makeup therapy had a chronic beneficial effect on the cognitive function of female dementia patients, while the chronic effect of makeup therapy on facial appearance was successfully detected by the present AI software.

    DOI: 10.3233/JAD-215385

    PubMed

    researchmap

  • ALS患者脊髄では低酸素ストレスの増加が起きている

    山下 徹, 畠山 哲宗, 佐藤 恒太, 福井 裕介, 武本 麻美, 太田 康之, 西山 佳宏, 河井 信行, 田宮 隆, 阿部 康二

    神経治療学   38 ( 6 )   S267 - S267   2021.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • Accelerated accumulation of fibrinogen peptide chains with Aβ deposition in Alzheimer's disease (AD) mice and human AD brains. International journal

    Zhihong Bian, Toru Yamashita, Xiaowen Shi, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Yoshio Omote, Ryuta Morihara, Koji Abe

    Brain research   1767   147569 - 147569   2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Alzheimer's disease (AD) is a common neurodegenerative disease that is characterized by the abnormal accumulation of intracellular and extracellular amyloid-β (Aβ) as well as disruption of the blood brain barrier (BBB). Fibrinogen plays an essential role in regulating thrombosis, wound healing, and other biological functions. In the present study, we investigated the relationship between three polypeptide chains α, β, and γ (FGA, FGB, and FGG) and Aβ deposition in the APP23 plus chronic cerebral hypoperfusion (CCH) mice model as well as the human AD brain. FGA, FGB, and FGG accumulated when Aβ was deposited in neural cells and cerebral vessels. This deposition was significantly higher in AD plus CCH mice models relative to wild-type brains, and in human AD brains compared to control brains. The present study demonstrates that FGA, FGB, and FGG are associated with AD progress, and can thus be potential targets for the diagnosis and therapy of AD.

    DOI: 10.1016/j.brainres.2021.147569

    PubMed

    researchmap

  • Successful treatment of anti-GAD antibody-associated autoimmune cerebellar ataxia with combined immunotherapies

    Yoshio Omote, Chika Matsuoka, Ryo Sasaki, Nozomi Hishikawa, Yuko Kawahara, Emi Nomura, Namiko Matsumoto, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Anti-glutamic acid decarboxylase (GAD) antibody (Ab)-associated autoimmune cerebellar ataxia (CA) is a rare neurological disorder, and a standardized therapy has not been established. Here, we report on a 58 year-old man with type 1 diabetes mellitus, who developed progressive CA with high levels of serum and cerebrospinal fluid (CSF) anti-GAD-Ab. He was initially treated with intravenous high-dose methylprednisolone and intravenous immunoglobulin (IVIg), but his CA was gradually worsened. Additional combined immunotherapies with plasma exchange, intravenous cyclophosphamide, and rituximab finally stabilized the progressive CA and suppressed the CSF anti-GAD-Ab index. Our case suggests the effectiveness of combined immunotherapies against progressive CA and the usefulness of the CSF anti-GAD-Ab index as a therapeutic indicator.

    DOI: 10.1111/ncn3.12541

    Web of Science

    researchmap

  • Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test. International journal

    Koh Tadokoro, Toru Yamashita, Yusuke Fukui, Emi Nomura, Yasuyuki Ohta, Setsuko Ueno, Saya Nishina, Keiichiro Tsunoda, Yosuke Wakutani, Yoshiki Takao, Takahiro Miyoshi, Yasuto Higashi, Yosuke Osakada, Ryo Sasaki, Namiko Matsumoto, Yuko Kawahara, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Koji Abe

    Journal of the neurological sciences   427   117529 - 117529   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0.01 vs NC) and AD (**p < 0.01 vs NC, ##p < 0.01 vs MCI), and correlated well with the mini-mental state examination (MMSE) score (r = 0.57, *p < 0.05). Furthermore, the eye tracking test, especially memory and deductive reasoning tasks, effectively discriminated NC, MCI and AD. The present novel eye tracking test clearly discriminated cognitive functions among NC, MCI, and AD subjects, thereby providing an advantage for the early detection of MCI and AD in screening.

    DOI: 10.1016/j.jns.2021.117529

    PubMed

    researchmap

  • A case of rheumatoid meningoencephalitis induced by pembrolizumab

    Chika Matsuoka, Yoshio Omote, Yuko Kawahara, Ryo Sasaki, Namiko Matsumoto, Ko Tadokoro, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Immune checkpoint inhibitors occasionally cause various side effects, but the occurrence of a severe immune-related adverse event (irAE) is rare in neurology. We report on a 56-year-old woman who suffered from rheumatoid arthritis and recurrent uterine cancer. After treatment with pembrolizumab, she showed visual disturbance followed by acute fever and consciousness disturbance with high-intensity lesions around the midbrain aqueduct and bilateral caudate heads on FLAIR images of a brain MRI. Her symptoms improved after steroid therapy. However, symptoms relapsed leading to an elevation of the anti-CCP antibody index. Pembrolizumab-induced rheumatoid meningoencephalitis was suspected, so additional steroid therapy was provided. This improved her symptoms, turning the anti-CCP antibody index negative. The present case is the first case of rheumatoid meningoencephalitis induced by pembrolizumab. The combination of MRI findings and elevated anti-CCP index seems useful for diagnosing rheumatoid meningoencephalitis.

    DOI: 10.1111/ncn3.12540

    Web of Science

    researchmap

  • Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. International journal

    Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Abe

    Neuroscience   466   47 - 57   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The degradation of damaged proteins takes place via two major proteolytic pathways: the ubiquitin-proteasome system (UPS) and autophagy. However, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), we investigated the switching mechanism from UPS to autophagy by pharmacologically modifying these pathways by treating the spinal cords of female ALS mouse model bearing G93A human SOD1 (G93A mice) with MG132 or 3-methyladenine (3MA). G93A mice exhibited a progressive increase in the amount of ubiquitin and p62 aggregates, BAG3 expression, and LC3-II/LC3-I ratio in both astroglia and motor neurons. Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated α-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression. This study's results demonstrate that the molecular switch from UPS to autophagy occurred not only in motor neurons but also in astroglia at the end stage (18 weeks) when the autophagic flux was impaired in G93A mice. This finding suggests that the defense system was disrupted against aggregate-prone protein production in ALS.

    DOI: 10.1016/j.neuroscience.2021.04.034

    PubMed

    researchmap

  • A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome.

    Namiko Matsumoto, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yoshio Omote, Mami Takemoto, Toru Yamashita, Kohei Taniguchi, Koji Abe

    Internal medicine (Tokyo, Japan)   60 ( 13 )   2125 - 2128   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case.

    DOI: 10.2169/internalmedicine.6098-20

    PubMed

    researchmap

  • The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration

    Yuki Taira, Yoshio Omote, Yuko Kawahara, Emi Nomura, Ryo Sasaki, Namiko Matsumoto, Chika Matsuoka, Mami Takemoto, Ryuta Morihara, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 4 )   346 - 348   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report on a 35-year-old man who had gender dysphoria following unilateral ovariectomy and then received continuous testosterone injection for nine years, inducing chronic inflammatory demyelinating polyneuropathy (CIDP). He developed recurrent muscle weakness and numbness in the extremities and displayed demyelinating neuropathy, detected by nerve conduction studies and a sural nerve biopsy. Repeated intravenous immunoglobulin (IVIg) therapy and the administration of oral prednisolone improved symptoms and inhibited their recurrence. A relatively high level of serum testosterone as a genetic female might have caused the neurotoxicity of the peripheral nerve, leading to CIDP.

    DOI: 10.1111/ncn3.12514

    Web of Science

    researchmap

  • AIを用いたパーキンソン病患者の見た目年齢・感情の評価

    田所 功, 山下 徹, 福井 裕介, 武本 麻美, 佐々木 諒, 松本 菜見子, 野村 恵美, 森原 隆太, 表 芳夫, 阿部 康二

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   15回   81 - 81   2021.7

     More details

    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

    researchmap

  • Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. International journal

    Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Koh Tadokoro, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Mari Dezawa, Koji Abe

    Scientific reports   11 ( 1 )   12828 - 12828   2021.6

     More details

  • Hypoxic stress visualized in the cervical spinal cord of ALS patients. International journal

    Toru Yamashita, Tetsuhiro Hatakeyama, Kota Sato, Yusuke Fukui, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yoshihiro Nishiyama, Nobuyuki Kawai, Takashi Tamiya, Koji Abe

    Neurological research   43 ( 6 )   429 - 433   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Objective: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease. Hypoxic stress is suspected as the pathogenesis of ALS, however, no positron emission tomography (PET) study for hypoxic stress has been conducted in the spinal cord of ALS patients.Methods: In the present study, we examined cervical spinal hypoxic stress of nineALS patients with upper extremity (U/E) atrophy by18F-fluoromisonidazole (FMISO) PET.Results: On the ipsilateral side of C1 and C5 levels, 18F-FMISO uptake increased significantly compared with the contralateral side (*p < 0.05) and the control subject (**p < 0.01). In addition, a strong correlation was found between 18F-FMISO uptake of the C5 level and the rate of progression of the ALS FRS-R score (R = 0.781, *p = 0.013).Conclusion: These results indicate that hypoxic stress increased in the spinal cord of ALS patients with a close link to ALS progression. Both hypoxic stress and a compromised response to hypoxia, which may lead to subsequent motor neuron death, could be a potential therapeutic target for ALS.

    DOI: 10.1080/01616412.2020.1866383

    PubMed

    researchmap

  • ALS患者における低酸素ストレスを可視化する

    山下 徹, 畠山 哲宗, 佐藤 恒太, 福井 裕介, 菱川 望, 武本 麻美, 太田 康之, 西山 佳宏, 河井 信行, 田宮 隆, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   21回   214 - 214   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • 化粧美容セラピーの認知・情動機能改善効果

    田所 功, 川野 公子, 佐藤 順子, 谷 都美子, 表 芳夫, 武本 麻美, 森原 隆太, 山下 徹, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   21回   211 - 211   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • AIを用いたパーキンソン病の顔についての解析

    田所 功, 山下 徹, 福井 裕介, 武本 麻美, 佐々木 諒, 松本 菜見子, 野村 恵美, 表 芳夫, 森原 隆太, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   21回   222 - 222   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • AIによる新しい脳機能・認知症診断 AIなどの新たな技術を活用した認知症診療

    田所 功, 佐々木 諒, 松本 菜見子, 福井 裕介, 表 芳夫, 武本 麻美, 森原 隆太, 山下 徹, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   21回   155 - 155   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • ALS患者における低酸素ストレスを可視化する

    山下 徹, 畠山 哲宗, 佐藤 恒太, 福井 裕介, 菱川 望, 武本 麻美, 太田 康之, 西山 佳宏, 河井 信行, 田宮 隆, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   21回   214 - 214   2021.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. International journal

    Xiaowen Shi, Yasuyuki Ohta, Yumiko Nakano, Xia Liu, Koh Tadokoro, Tian Feng, Emi Nomura, Keiichiro Tsunoda, Ryo Sasaki, Namiko Matsumoto, Yosuke Osakada, Yuting Bian, Zhihong Bian, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    Neuroscience research   166   55 - 61   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Cu-diacetyl-bis (N4-methylthiosemicarbazone) (CuATSM) has both anti-oxidative and anti-inflammatory activities, but its therapeutic efficacy for oxidative stress has not been thoroughly investigated in acute ischemic stroke. Here, the present study was designed to assess the efficacies of CuATSM in acute ischemic stroke by comparing with the standard neuroprotective reagent edaravone. Mice were subjected to transient middle cerebral occlusion (tMCAO) for 60 min, and then intravenously administrated with CuATSM (1.5 mg/kg) or edaravone (3 mg/kg) just after the reperfusion, and examined at 1 and 3 d. Compared with the vehicle group, CuATSM treatment decreased infarct volumes and oxidative stress at 3d after tMCAO, which was further enhanced by combined CuATSM + edaravone treatment as compared with single CuATSM group, but not improve neurobehaviors. The present study demonstrated that CuATSM showed strong antioxidative and neuroprotective effects in acute ischemic stroke, which was enhanced by the combination with edaravone.

    DOI: 10.1016/j.neures.2020.05.009

    PubMed

    researchmap

  • Positive baseline behavioral and psychological symptoms of dementia predict a subsequent cognitive impairment in cognitively normal population

    Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Noriko Hatanaka, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 3 )   218 - 222   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Background: Because behavioral and psychological symptoms of dementia (BPSD) are sometimes prodromal symptoms of dementia, it is important to investigate the relationship between BPSD and subsequent cognitive decline.Methods: We examined the cognitive and affective functions of 76 cognitively normal subjects at initial assessment (baseline) and 1-year follow-up. Cognitive function was assessed using clinical dementia rating (CDR) and Mini-Mental State Examination (MMSE), and affective function was assessed using Abe's BPSD score (ABS) and mild behavioral impairment (MBI).Results: Although there was no change in MMSE, ABS, or MBI after 1 year, the mean CDR score of 0 at baseline increased to 0.1 +/- 0.2 at 1-year follow-up (**P < 0.01 vs baseline). No significant change in MMSE was found in both baseline ABS and MBI positive- or negative-groups. In contrast, baseline MBI-dependent CDR change showed a 13.2% of worsening in MBI-negative subjects and a 62.5% of MBI-positive subjects (dagger dagger P < 0.01), but ABS not.Conclusion: The present data indicate that positive baseline BPSD with MBI was closely related to a subsequent CDR exacerbation. Examining BPSD may be useful for screening cognitively normal population for subsequent dementia development in local communities.

    DOI: 10.1111/ncn3.12492

    Web of Science

    researchmap

  • 4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients. International journal

    Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Watanabe, Kentaro Deguchi, Koji Tokunaga, Susumu Sasada, Kazuki Kobayashi, Ryosuke Maeoka, Kenji Fukutome, Kenkichi Takahashi, Hiroyuki Ohnishi, Yoshihiro Kuga, Hideyuki Ohnishi, Koji Abe

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   30 ( 3 )   105583 - 105583   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: The relationship between stroke etiology and clot pathology remains controversial. MATERIALS AND METHODS: We performed histological analysis of clots retrieved from 52 acute ischemic stroke patients using hematoxylin and eosin staining and immunohistochemistry (CD42b and oxidative/hypoxic stress markers). The correlations between clot composition and the stroke etiological group (i.e., cardioembolic, cryptogenic, or large artery atherosclerosis) were assessed. RESULTS: Of the 52 clots analyzed, there were no significant differences in histopathologic composition (e.g., white blood cells, red blood cells, fibrin, and platelets) between the 3 etiological groups (P = .92). By contrast, all large artery atherosclerosis clots showed a localized pattern with the oxidative stress marker 4-hydroxyl-2-nonenal (P < .01). From all 52 clots, 4-hydroxyl-2-nonenal expression patterns were localized in 28.8% of clots, diffuse in 57.7% of clots, and no signal in 13.5% of clots. CONCLUSIONS: A localized pattern of 4-hydroxyl-2-nonenal staining may be a novel and effective marker for large artery atherosclerosis (sensitivity 100%, specificity 82%).

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.105583

    PubMed

    researchmap

  • A new telestroke network system in northern area of Okayama prefecture

    Ryo Sasaki, Toru Yamashita, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Taijun Yunoki, Kazuki Kobayashi, Takashi Sawata, Yuki Sato, Junichi Kubota, Masayuki Mizobuchi, Takashi Hayashi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 2 )   166 - 170   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Background: Telestroke network can provide rapid access to specialized treatment and improves on-site management of acute stroke patients through the "hub-and-spoke" model. In the northern part of Okayama Prefecture, there has been a regional gap of stroke care due to the shortage of stroke specialists and facilities. In addition, due to the novel coronavirus disease 2019 (COVID-19), it is required to reduce the unnecessary contact with stroke patients from other hospitals.Aim: We organized a novel cost-free telestroke network with an image and video sharing for neurological diseases in the northern part of Okayama Prefecture to improve the stroke management in the area.Method: We prepared the tablet device on which Skype(R) application was installed for each hospital and recruited the patients who visited or hospitalized in the spoke hospitals and were suspected to have some neurological diseases from April 2019 to May 2020. The patient's clinical data were recorded and analyzed.Results: During the study period, 5 patients were recruited including the cases with the initial diagnosis of stroke or brain tumor. Among them, 2 cases were transferred to the hub hospital, 2 cases were transferred to other hospitals, and 1 case was treated on site under specialist's advice.Conclusion: The new telestroke network system may be beneficial for acute stroke management and reducing the unnecessary patient's transfer in the rural area, especially under coexistence with COVID-19.

    DOI: 10.1111/ncn3.12475

    Web of Science

    researchmap

  • The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years After the First Instance of Optic Neuritis.

    Emi Nomura, Yuko Kawahara, Yoshio Omote, Koh Tadokoro, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hidenori Ogata, Koji Abe

    Internal medicine (Tokyo, Japan)   60 ( 2 )   305 - 308   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Combined central and peripheral demyelination (CCPD) causes demyelination in both the central and peripheral nervous systems. Anti-neurofascin 155 antibody plays an important pathogenic role in CCPD, but evidence concerning an association between this antibody and CCPD remains inconclusive. Although there have been no reports of precedent optic neuritis developing into CCPD, we herein report a Japanese man in whom optic neuritis recurred four times over nine years and who developed CCPD without positive anti-neurofascin 155 antibody. This case suggests the possibility of developing CCPD after optic nerve neuritis and the existence of an unknown antibody that induces CCPD.

    DOI: 10.2169/internalmedicine.5536-20

    PubMed

    researchmap

  • A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

    Yasuyuki Ohta, Hitoshi Shimada, Ken Ikegami, Keiichiro Tsunoda, Nozomi Hishikawa, Toru Yamashita, Mami Takemoto, Yoshio Omote, Kenji Tagai, Kiwamu Matsuoka, Makoto Higuchi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 1 )   124 - 126   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), frequently observed in the Kii peninsula of Japan, is pathologically characterized by widespread tau pathology in the cerebrum and brainstem. Here, we report a case of Kii ALS/PDC predominantly presenting progressive parkinsonism. Tau positron emission tomography (PET) imaging with F-18-PM-PBB3 suggested tau deposition in the substantia nigra of the midbrain and subcortical areas, but not in the cerebral cortex, which was similar to progressive supranuclear palsy (PSP), suggesting that parkinsonism-predominant type of Kii ALS/PDC may have a similar area of tau deposition to PSP.

    DOI: 10.1111/ncn3.12463

    Web of Science

    researchmap

  • A case of autoimmune GFAP astrocytopathy with profound weight loss and increased uptake in the spinal cord on F-18-FDG PET

    Yosuke Osakada, Yoshio Omote, Ken Ikegami, Koh Tadokoro, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Akio Kimura, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   9 ( 1 )   95 - 97   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    A 76-year-old man presented with subacute onset of progressive cognitive impairment, anorexia, tremor, ataxic gait, and urinary dysfunction. He had lost 17 kg in 9 months before his admission (due to persistent anorexia). A brain MRI showed a typical radial pattern of periventricular gadolinium enhancement and longitudinally extensive hyperintensity from cervical to lumbar spinal cord. F-18-FDG PET newly revealed an increased uptake of the tracer in the cervical and lower thoracic cords. After an intravenous methylprednisolone (1000 mg/d for 3 days) followed by oral prednisolone 40 mg/d, his clinical symptoms and abnormal MRI lesions improved. Anti-GFAP antibodies were subsequently identified in CSF obtained on admission, confirming the diagnosis of autoimmune GFAP astrocytopathy.

    DOI: 10.1111/ncn3.12441

    Web of Science

    researchmap

  • Retinal Amyloid Imaging for Screening Alzheimer's Disease. International journal

    Koh Tadokoro, Toru Yamashita, Shuhei Kimura, Emi Nomura, Yasuyuki Ohta, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Yuki Morizane, Koji Abe

    Journal of Alzheimer's disease : JAD   83 ( 2 )   927 - 934   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Cost-effective and noninvasive methods for in vivo imaging of amyloid deposition are needed to screen Alzheimer's disease (AD). Although retinal amyloid is a possible diagnostic marker of AD, there are very few studies on in vivo retinal amyloid imaging. OBJECTIVE: To examine the usefulness of in vivo imaging of retinal amyloid in AD patients. METHODS: To examine amyloid deposition, 30 Japanese subjects (10 normal control (NC), 7 with mild cognitive impairment (MCI), and 13 with AD) underwent a complete ophthalmic examination, including fundus imaging by scanning laser ophthalmoscopy before and after oral curcumin intake. RESULTS: Retinal amyloid deposition was greater in AD than in NC subjects (*p < 0.05) while MCI showed a slight but insignificant increase of retinal amyloid deposition relative to NC subjects. Retinal amyloid deposition was correlated with whole gray matter atrophy (r = 0.51, *p < 0.05) but not with the cognitive score of the Mini-Mental State Examination, nor with medial temporal lobe atrophy. CONCLUSION: The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening AD patients.

    DOI: 10.3233/JAD-210327

    PubMed

    researchmap

  • Immediate Beneficial Effect of Makeup Therapy on Behavioral and Psychological Symptoms of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. International journal

    Koh Tadokoro, Toru Yamashita, Satoko Kawano, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Natsuki Sagawa, Tomiko Tani, Koji Abe

    Journal of Alzheimer's disease : JAD   83 ( 1 )   57 - 63   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Possible benefits of makeup therapy, in terms of immediate and late effects on cognitive and affective functions, have not been fully proved for dementia patients. OBJECTIVE: To evaluate the immediate effect of makeup therapy on dementia patients. METHODS: Female nursing home residents with dementia received either only skin care treatment (control group, n = 17) or skin care plus makeup therapy treatment (makeup therapy group, n = 19). Cognitive, affective, and activity of daily living (ADL) scores were evaluated before and just after treatments. Apparent age and emotion were also evaluated with artificial intelligence (AI) software. RESULTS: Makeup therapy significantly improved Abe's behavioral and psychological symptoms of dementia (BPSD) score (ABS, *p < 0.05). AI software judged that makeup therapy significantly made the apparent age younger (*p < 0.05). In particular, patients with moderate ADL scores had a significantly higher happiness score in makeup therapy (*p < 0.05), with a modest correlation to the Mini-Mental State Examination (MMSE, r = 0.42, *p < 0.05). The severe baseline MMSE group reported a greater feeling of satisfaction following makeup therapy (*p < 0.05). CONCLUSION: The present makeup therapy is a promising non-pharmacological approach to immediately alleviate BPSD in female dementia patients, and the present AI software quickly and quantitatively evaluated the beneficial effects of makeup therapy on facial appearance.

    DOI: 10.3233/JAD-210284

    PubMed

    researchmap

  • Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging. International journal

    Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Koh Tadokoro, Yoshio Omote, Ryuta Morihara, Koji Abe

    Journal of Alzheimer's disease : JAD   80 ( 1 )   331 - 335   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. OBJECTIVE: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99 mTc-ECD SPECT subtraction images of these two diseases. METHODS: We examined 112 patients with PD (53 males and 59 females; age: 77.4±3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1±6.7 years) using brain magnetic resonance imaging (MRI) and 99 mTc-ECD SPECT subtraction imaging. RESULTS: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7±1.1) than the latter (0.2±0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99 mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. CONCLUSION: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.

    DOI: 10.3233/JAD-201495

    PubMed

    researchmap

  • Tocilizumab-induced Leukoencephalopathy with a Reversible Clinical Course.

    Ryo Sasaki, Nozomi Hishikawa, Emi Nomura, Yoshio Omote, Mami Takemoto, Toru Yamashita, Noriko Hatanaka, Yasuto Higashi, Koji Abe

    Internal medicine (Tokyo, Japan)   59 ( 22 )   2927 - 2930   2020.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Tocilizumab (TCZ; Actemra/RoActemra) is an anti-interleukin (IL)-6 receptor antibody for the treatment of rheumatoid arthritis (RA) and other autoimmune diseases and cytokine storms. The present case is a 63-year-old female well-controlled RA patient, who presented with a progressive cognitive impairment after 34 months of TCZ administration. Brain magnetic resonance imaging (MRI) showed leukencephalopathy with a lactic acid peak in magnetic resonance spectroscopy (MRS), a decreased blood flow in single photon emission computed tomography (SPECT), and a decreased accumulation in fluorodeoxyglucose positron emission tomography (FDG-PET). The discontinuation of TCZ improved her cognitive function and brain MRI findings at 3 months after drug cessation. The present case suggests that TCZ may sometimes cause leukoencephalopathy after long-term administration, and thus the early discontinuation of TCZ is recommended to achieve a good prognosis.

    DOI: 10.2169/internalmedicine.5288-20

    PubMed

    researchmap

  • Repeat sizes of NOP56 gene in a Japanese Asidan (SCA36) family with clinical anticipation. International journal

    Yasuyuki Ohta, Ken Ikegami, Kota Sato, Nozomi Hishikawa, Yoshio Omote, Mami Takemoto, Toru Yamashita, Koji Abe

    Journal of the neurological sciences   418   117150 - 117150   2020.11

     More details

  • 認知機能正常者ならびに軽度認知障害における認知症周辺症状の出現

    角田 慶一郎, 山下 徹, 小坂田 陽介, 佐々木 諒, 田所 功, 松本 菜見子, 野村 恵美, 森原 隆太, 中野 由美子, 高橋 義秋, 幡中 典子, 商 敬偉, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    臨床神経学   60 ( Suppl. )   S445 - S445   2020.11

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • ALS患者脊髄における低酸素ストレスを可視化する

    山下 徹, 畠山 哲宗, 佐藤 恒太, 福井 裕介, 菱川 望, 武本 麻美, 太田 康之, 西山 佳宏, 河井 信行, 田宮 隆, 阿部 康二

    脳循環代謝   32 ( 1 )   102 - 102   2020.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. International journal

    Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Koh Tadokoro, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Mari Dezawa, Koji Abe

    Scientific reports   10 ( 1 )   17102 - 17102   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. Muse cells are endogenous reparative pluripotent-like stem cells distributed in various tissues. They can selectively home to damaged sites after intravenous injection by sensing sphingosine-1-phosphate produced by damaged cells, then exert pleiotropic effects, including tissue protection and spontaneous differentiation into tissue-constituent cells. In G93A-transgenic ALS mice, intravenous injection of 5.0 × 104 cells revealed successful homing of human-Muse cells to the lumbar spinal cords, mainly at the pia-mater and underneath white matter, and exhibited glia-like morphology and GFAP expression. In contrast, such homing or differentiation were not recognized in human mesenchymal stem cells but were instead distributed mainly in the lung. Relative to the vehicle groups, the Muse group significantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles. These results suggest that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of ALS patients.

    DOI: 10.1038/s41598-020-74216-4

    PubMed

    researchmap

  • Direct arterial damage and neurovascular unit disruption by mechanical thrombectomy in a rat stroke model

    Ryo Sasaki, Toru Yamashita, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF NEUROSCIENCE RESEARCH   98 ( 10 )   2018 - 2026   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Mechanical thrombectomy (MT) is a standard treatment for acute ischemic stroke that could cause hemorrhagic complications. We aimed to evaluate the pathology of MT-induced arterial damage and neurovascular unit (NVU) disruption in relation to tissue-type plasminogen activator (tPA) injection for acute ischemic stroke. We induced transient middle cerebral artery occlusion in male SHR/Izm rats for 2 hr. This was followed by reperfusion with/without tPA (3 mg/kg) and "rough suture" insertion that mimicked MT once or thrice (MT1 or MT3). Compared with the control group, the tPA + MT3 group presented with an increase in the cerebral infarct and hemorrhage with severer IgG leakage. Moreover, structural damage reaching the tunica media was detected in the MT3 and tPA + MT3 groups. The tPA + MT3 group presented with increased matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) expression with some MMP9-positive cells expressing a neutrophil marker myeloperoxidase. Furthermore, basal lamina detachment from astrocyte foot processes was observed in the tPA + MT1 and tPA + MT3 groups. These findings suggest that MT causes direct arterial damage, as well as VEGF and MMP9 upregulation, which results in NVU disruption and hemorrhagic complications in acute ischemic stroke, especially when combined with tPA.

    DOI: 10.1002/jnr.24671

    Web of Science

    researchmap

  • 脳梗塞後に神経細胞を新たに生み出し再生を目指す 脳内グリア細胞から神経細胞を誘導する新技術の確立

    山下 徹, 商 敬偉, 中野 由美子, 森原 隆太, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    神経治療学   37 ( 6 )   S253 - S253   2020.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • Clinical anticipation of disease onset in a Japanese Asidan (SCA36) family. International journal

    Yasuyuki Ohta, Ken Ikegami, Kota Sato, Nozomi Hishikawa, Yoshio Omote, Mami Takemoto, Toru Yamashita, Koji Abe

    Journal of the neurological sciences   416 ( 15 )   117043 - 117043   2020.9

     More details

  • A case of triple seronegative myasthenia gravis with Graves' disease ameliorated after the removal of enlarged thymus with elevated uptake in fluorine-18 fluorodeoxyglucose positron emission tomography

    Namiko Matsumoto, Yoshio Omote, Yumiko Nakano, Mami Takemoto, Nozomi Hishikawa, Kota Sato, Yasuyuki Ohta, Toru Yamashita, Tomohiro Toji, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 5 )   313 - 316   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report on a 35-year-old woman who complained of myasthenia in ocular, bulbar, and limb muscles, but who was negative for antibodies against acetylcholine receptor, muscle-specific kinase, or low-density lipoprotein receptor-related protein 4, accompanied by the suppression of thyroid-stimulating hormone with elevated free T3 and free T4. Administration of edrophonium significantly ameliorated blepharoptosis, and electromyography revealed 13.9% waning after 3 Hz repetitive stimulation in the left accessory nerve. Thus, she was suspected of having triple seronegative myasthenia gravis or thyrotoxic myasthenia. She was remitted after the resection of her enlarged thymus with an elevated uptake in fluorine-18 fluorodeoxyglucose positron emission tomography, suggesting an unknown autoimmune target that escaped detection by current autoantibody screens. Consequently, thymectomy may still be effective in patients with seronegative MG plus hyperthyroidism.

    DOI: 10.1111/ncn3.12414

    Web of Science

    researchmap

  • Dynamic changes and mislocalizations of neurodegenerative disease-related proteins in mice stroke model

    Xia Liu, Toru Yamashita, Xiaowen Shi, Yuting Bian, Zhihong Bian, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    BRAIN RESEARCH   1742 ( 1 )   146862   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    The aggregation and cellular mislocalization of several RNA-binding proteins (RBPs) have been identified as the major hallmarks of neurodegenerative diseases such as frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). However, it remains obscure whether these pathological changes also occur during cerebral ischemia. In this study, we report that RBPs increased significantly compared with the sham group (*p < 0.05 and **p < 0.01 vs sham), with nuclear depletion and cytoplasmic deposition in neurons in the acute phase of cerebral ischemia. On the other hand, such nucleocytoplasmic mislocalization were not observed in astrocytes. We provide evidence of the alteration of these neurodegeneration-related RBPs after cerebral ischemia, suggesting a potential association between cerebral ischemia and neurodegenerative diseases.

    DOI: 10.1016/j.brainres.2020.146862

    Web of Science

    researchmap

  • A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation.

    Sasaki R, Omote Y, Tadokoro K, Matsumoto N, Nomura E, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, and Abe K

    Neurology Asia   25 ( 3 )   415 - 418   2020.9

     More details

    Language:English  

    researchmap

  • Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients

    Yasuyuki Ohta, Toru Yamashita, Emi Nomura, Nozomi Hishikawa, Ken Ikegami, Yosuke Osakada, Namiko Matsumoto, Yuko Kawahara, Taijun Yunoki, Yoshiaki Takahashi, Motonori Takamiya, Koh Tadokoro, Ryo Sasaki, Yumiko Nakano, Keiichiro Tsunoda, Kota Sato, Yoshio Omote, Mami Takemoto, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   415 ( 15 )   116906   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: The free radical scavenger edaravone is a proven neuroprotective drug for patients with amyotrophic lateral sclerosis (ALS). Our objective was to evaluate the therapeutic effects of edaravone for oxidative stress and anti-oxidative activity in ALS patients.Methods: Twenty-two ALS patients with a disease duration of 2 years, treated by edaravone, and 25 control participants were evaluated according to their clinical scores, including ALS functional rating scale-revised (ALSFRS-R), and serum and cerebrospinal fluid (CSF) markers of oxidative stress dROM and anti-oxidative activity OXY.Results: Serum and CSF markers of anti-oxidative activity OXY were significantly decreased in ALS patients at pre-treatment compared with controls ((##)p < .01), which was improved in the course of edaravone treatment. Both serum and CSF OXY were significantly correlated with ALS clinical scores including ALSFRS-R (*p < .05, **p < .01, ***p < .001). Furthermore, serum OXY at pre-treatment was significantly correlated with a change in the ALSFRS-R score in the sixth cycle of edaravone treatment (*p < .05).Conclusions: The present study suggests significant correlations between anti-oxidative activity and ALS clinical severity, and the therapeutic efficacy of edaravone for decreased anti-oxidative activity in ALS.

    DOI: 10.1016/j.jns.2020.116906

    Web of Science

    researchmap

  • Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model. International journal

    Yuki Taira, Toru Yamashita, Yuting Bian, Jingwei Shang, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Keiichiro Tsunoda, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   29 ( 8 )   104818 - 104818   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: During an acute stroke, reactive oxygen species are overproduced and the endogenous antioxidative defense systems are disrupted. Therefore, antioxidative therapy can be a promising scheme to reduce the severity of stroke. Neumentix is a novel antioxidative supplement produced from a patented mint line and contains a high content of rosmarinic acid (RA). Although Neumentix has proven diverse efficacy and safety in clinical trials, its effect on strokes is unclear. METHODS: Mice that were treated with Neumentix or vehicle for 14 days underwent transient middle cerebral artery occlusion (tMCAO) for 60 min. Mice were sacrificed 5 days after tMCAO. RESULTS: Neumentix preserved body weight after tMCAO, showed a high antioxidative effect in serum, and reduced infarction volume compared to the vehicle. The expression of 4-hydroxy-2-nonenal, Nε-(carboxymethyl) lysine, and 8-hydroxy-2'-deoxyguanosine was reduced in Neumentix-treated mice. CONCLUSION: The antioxidative effect of Neumentix was confirmed. This is the first report to demonstrate the antioxidative effect of Neumentix on strokes.

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.104818

    PubMed

    researchmap

  • Adult-onset frequent non-convulsive status epilepticus in a patient with ring chromosome 20 syndrome

    Xia Liu, Yoshio Omote, Ken Ikegami, Koh Tadokoro, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 4 )   202 - 204   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report a 31-year-old woman with ring chromosome 20 syndrome who presented with epilepsy staring from 16 years old and loss of consciousness from 30 years old. Her neurological examinations and psychological testing were normal, without dysmorphic features. No abnormalities were found in neuroimaging. Electroencephalogram recording showed typical non-convulsive status epilepticus associated with alteration of consciousness. Her diagnosis was based on the cytogenetic analysis indicating that her karyotype was 46, XX, r(20)(p13q13.3)[9]/46, XX[21]. She had refractory epilepsy and improved by a combination of valproate and lacosamide.

    DOI: 10.1111/ncn3.12389

    Web of Science

    researchmap

  • PDDとDLBの認知機能と情動機能、脳血流画像の比較

    武本 麻美, 田所 功, 表 芳夫, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    日本老年医学会雑誌   57 ( Suppl. )   111 - 112   2020.7

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice

    Namiko Matsumoto, Toru Yamashita, Jingwei Shang, Tian Feng, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Keiichiro Tsunoda, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    BRAIN RESEARCH   1739 ( 15 )   146831   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    There is thought to be a strong relationship between sphingosine-1-phosphate (S1P) signaling and pathophysiolosy of cerebral ischemia. We examined the change of expression and distribution of SIP receptors (S1PRs) and sphingosine kinases (SphKs) after cerebral ischemia in male C57BL6/J mice using immunohistochemical analysis at 1, 5, 14, and 28 days after 30 min of transient middle cerebral artery occlusion (tMCAO). S1PR1, 3, and 5 were transiently induced in the cells, which were morphologically similar to neurons in the pert-infarct lesion with a peak seen at 1 day after tMCAO (p < 0.01 vs. sham control). S1PR2 appeared in the inner layer of vessels in the ischemic core (p < 0.01 vs. sham control) and the pert-infarct lesion (p < 0.01 vs. sham control) at the acute phase after tMCAO. However, SphK1 was strongly induced at 1 and 5 days after tMCAO (p < 0.01 vs. sham control) in the peri-infarct lesion, whereas SphK2 expression did not change. Western blot analysis at 1 and 5 days after 30 min of tMCAO revealed that the expression of S1PRs were transiently enhanced at the acute phase, which was consistent with the immunohistochemical results. Double immunofluorescent analysis revealed S1PR2/NG2- and S1PR2/CD31-, S1PR3/CD31-, and S1PR5/CD31-double positive cells in the peri-infarct lesion 1 day after tMCAO. The present results suggest that S1PRs and SphK1 may be important therapeutic targets for rescuing the pert-infarct lesion.

    DOI: 10.1016/j.brainres.2020.146831

    Web of Science

    researchmap

  • Familial dropped head syndrome with extremity muscle weakness

    Keiichiro Tsunoda, Nozomi Hishikawa, Yoshio Omote, Ken Ikegami, Yumiko Nakano, Kota Sato, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 4 )   189 - 191   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report a new case of familial dropped head syndrome (DHS) due to myopathy. The proband is a 63-year-old woman, and her younger sister and son also showed DHS. She was not good at sport since elementary school and showed unique muscle weakness in her paraspine and four limbs. A blood test showed a slight increase in creatine kinase (237 IU/mL) and myoglobin (95 ng/mL). An electromyogram showed myogenic change, and computed tomography revealed a normal muscle volume of the neck but paraspinal muscle atrophy. Muscle biopsy of the right femoral muscle found type 2 fiber atrophy. Based on these unique clinical features, this is the first report of familial DHS which probably due to congenital myopathy.

    DOI: 10.1111/ncn3.12382

    Web of Science

    researchmap

  • 抗酸化サプリメントTwendee Xの軽度認知障害に対する効果についての検討

    松本 菜見子, 田所 功, 森原 隆太, 太田 康之, 菱川 望, 川野 公子, 武本 麻美, 山下 徹, 犬房 春彦, 阿部 康二

    日本老年医学会雑誌   57 ( Suppl. )   113 - 113   2020.7

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • Bone Marrow Stromal Cell Transplantation Drives Molecular Switch from Autophagy to the Ubiquitin-Proteasome System in Ischemic Stroke Mice

    Koh Tadokoro, Yusuke Fukui, Toru Yamashita, Xia Liu, Keiichiro Tsunoda, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Feng Tian, Ryo Sasaki, Namiko Matsumoto, Emi Nomura, Xiaowen Shi, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   29 ( 5 )   104743   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: Bone marrow stromal cell (BMSC) transplantation is a promising therapeutic approach for cerebral ischemia, as it elicits multiple neuroprotective effects. However, it remains unclear how BMSC transplantation modulates the ubiquitin-proteasome system (UPS) and autophagy under cerebral ischemia. Methods: In the present study, an intermediate level of cerebral ischemia (30 minutes) was chosen to examine the effect of BMSC transplantation on the molecular switch regulating UPS and autophagy. BMSC or vehicle was stereotactically injected into the penumbra 15 minutes after sham operation or transient middle cerebral artery occlusion (tMCAO). Results: Thirty minutes of tMCAO artery occlusion significantly increased TUNEL-, ubiquitin-, and p62-positive cells (which peaked at 72 hours, 2 hours, and 2 hours after reperfusion, respectively) and ratios of both BAG3/BAG1 and LC3-II/LC3-I at 24 hours after reperfusion. However, intracerebral injection of BMSCs significantly reduced infarct volume and numbers of TUNEL- and p62-positive cells, and improved BAG3/BAG1 and LC3-II/LC3-I ratios. In addition, observed increases in ubiquitin-positive cells 2 hours after reperfusion were slightly suppressed by BMSC transplantation. Conclusions: These data suggest a protective role of BMSC transplantation, which drove the molecular switch from autophagy to UPS in a murine model of ischemic stroke.

    DOI: 10.1016/j.jstrokecerebrovasdis.2020.104743

    Web of Science

    researchmap

  • Diabetic painful truncal neuropathy with hypohidrosis and facial palsy

    Keiichiro Tsunoda, Yoshio Omote, Nozomi Hishikawa, Ken Ikegami, Yumiko Nakano, Kota Sato, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 3 )   155 - 157   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Truncal neuropathy is a rare phenotype of diabetic neuropathy. Here, we report the first case of diabetic painful truncal neuropathy complaining of back pain with hypohidrosis confirmed by a sweat test accompanied by cranial nerve palsy. The patient had poorly controlled type 2 diabetes mellitus and suffered from back pain followed by facial palsy. After pulse therapy with methylprednisolone facial palsy improved, but back pain was intractable with a loss of body weight. The sweat test showed hypohidrosis on the back and soles on his feet. Sural nerve biopsy revealed decreased small fibers and mild axonopathy. After palliative therapy, his symptoms gradually improved.

    DOI: 10.1111/ncn3.12370

    Web of Science

    researchmap

  • A spontaneous recovery of anti-galactocerebroside antibody-associated encephalitis without evidence of Mycoplasma infection

    Koh Tadokoro, Yoshio Omote, Yosuke Osakada, Ken Ikegami, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 3 )   164 - 166   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Anti-galactocerebroside (Gal-C) antibody is characteristic of encephalomyelitis and Guillain-Barre syndrome subsequent to mycoplasma infection. Here, we report a 75-year-old Japanese man who presented somnolence, signs of meningeal irritation, and parkinsonian features with positive serum inflammatory markers and cerebrospinal fluid (CSF) pleocytosis. Although anti-Mycoplasma pneumoniae antibody was negative, anti-Gal-C antibody was later detected in his serum. The present case recovered spontaneously without any other specific therapies.

    DOI: 10.1111/ncn3.12379

    Web of Science

    researchmap

  • Discrepancy of subjective and objective sleep problems in Alzheimer's disease and mild cognitive impairment detected by a home-based sleep analysis

    Koh Tadokoro, Yasuyuki Ohta, Nozomi Hishikawa, Emi Nomura, Yosuke Wakutani, Yoshiki Takao, Yoshio Omote, Mami Takemoto, Toru Yamashita, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   74   76 - 80   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    There is a strong relationship between Alzheimer's disease (AD) and sleep problems, and a sleep condition is informative for evaluating the AD status. In the present study, we evaluated subjective sleep problems in AD and mild cognitive impairment (MCI) with self-check questionnaires and objective sleep problems with a convenient home-based portable device, WatchPAT. A total of 63 subjects with normal cognition (NC) (n = 22), MCI (n = 20), and AD (n = 21) were cross-sectionally investigated. AD patients showed a better self-check Pittsburgh sleep quality index (PSQI) score (*p < 0.05) than NC and MCI patients. On the other hand, WatchPAT analysis showed a significantly reduced rapid eye movement (REM) sleep (*p < 0.05) and increased light sleep in AD patients (*p < 0.05) compared with NC subjects, and mildly reduced REM and increased light sleep in MCI subjects. The present study revealed a gap between the subjective self-check sleep questions and the objective WatchPAT analysis in AD patients. Thus, a home-based sleep study with WatchPAT is a useful tool to detect an objective sleep problem in AD and the risk of MCI conversion into AD. (C) 2020 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2020.01.085

    Web of Science

    researchmap

  • A unique case of myasthenia gravis mimicking Garcin’s syndrome.

    Tadokoro K, Hishikawa N, Ikegami K, Nomura E, Kawahara Y, Omote Y, Takemoto M, Yamashita T, Abe K

    Neurol Clin Neurosci   1 - 4   2020.4

     More details

    Language:English  

    researchmap

  • Delayed Serial Microvascular Injury and Cognitive Decline After Whole Brain Irradiation.

    Osakada Y, Yamashita T, Ikegami K, Kawahara Y, Omote Y, Hishikawa N, Takemoto M, Ohta Y, Abe K

    Japanese Society of Vascular Cognitive Impairment   6   23 - 26   2020.4

     More details

    Language:English  

    researchmap

  • A juvenile case of idiopathic hypertrophic pachymeningitis involved cavernous sinus and proximal trigeminal nerve

    Zhihong Bian, Yoshio Omote, Koh Tadokoro, Ken Ikegami, Yosuke Osakada, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 2 )   82 - 85   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Idiopathic hypertrophic pachymeningitis (HP) is a rare inflammatory disorder characterized by local or diffuse thickening of the cranial or spinal dura mater, which is primarily reported in adults. Here, we report a juvenile idiopathic HP case presenting diplopia and multiple cranial nerve palsies. Although cranial magnetic resonance imaging (MRI) shows evident lesions in cavernous sinus and preganglionic segment of trigeminal nerve, only cerebrospinal fluid (CSF) showed elevated protein (55 mg/dL) and myelin basic protein (MBP, 355 pg/mL) but negative systemic inflammatory markers. Steroid therapy greatly improved the symptom and the CSF data in 1 month.

    DOI: 10.1111/ncn3.12355

    Web of Science

    researchmap

  • A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

    Namiko Matsumoto, Kota Sato, Nozomi Hishikawa, Yuko Kawahara, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Kentaro Fujii, Kazuhiko Kurozumi, Isao Date, Toshiyuki Takahashi, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 2 )   92 - 95   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    The accurate diagnosis of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases is sometimes challenging due to its various central nervous system (CNS) lesions. Here, we report a 22-year-old man with positive anti-MOG antibody presenting multiple brain lesions including a brainstem tumefactive demyelinating lesion (TDL), cortical edematous lesions, and a periventricular white matter lesion. These variety of lesions made the diagnosis challenging, especially because TDL is quite rare among MOG antibody-associated disease patients. The present case suggests the importance to check anti-MOG antibody for patients presenting atypical multiple CNS lesions.

    DOI: 10.1111/ncn3.12364

    Web of Science

    researchmap

  • LGI1 antibody-associated limbic encephalitis started from unilateral basal ganglia to medial temporal lobe and insula

    Xia Liu, Yoshio Omote, Yosuke Osakada, Koh Tadokoro, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 2 )   68 - 71   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Leucine-rich glioma-inactivated 1 (LGI1) antibody-associated limbic encephalitis is a rare autoimmune encephalitis. Here, we report a 39-year-old woman presented with generalized tonic-clonic seizures, night delirium, bilateral upper limb tremor, and hyponatremia. Her symptoms did not improve with initial steroid therapy, and brain magnetic resonance imaging (MRI) showed a progression of abnormalities from right basal ganglia to medial temporal lobe and insula. The presence of LGI1 antibodies in the patient's serum confirmed the clinical diagnosis. After the combined treatments of methylprednisolone, plasma exchange, and intravenous immunoglobulin, her clinical symptoms resolved completely.

    DOI: 10.1111/ncn3.12351

    Web of Science

    researchmap

  • Different clinical and neuroimaging features of Japanese dementia siblings with a new N-terminal mutation (Val225Ala) of APP gene

    Yasuyuki Ohta, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yosuke Osakada, Mami Takemoto, Toru Yamashita, Yoshio Omote, Takeshi Ikeuchi, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   72   482 - 484   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Autosomal dominant amyloid precursor protein (APP) mutations in familial Alzheimer's disease accelerate the amyloid beta (A beta) pathology. Here we describe Japanese siblings with a new N-terminal mutation (a heterogeneous c.674T>C, p.Val225Ala) of the APP gene, developing a progressive dementia at 57 years and A beta and tau pathologies in cerebrospinal fluid studies. However, the brother and sister showed different clinical and neuroimaging features, suggesting different A beta pathologies for each sibling. (C) 2019 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2019.11.009

    Web of Science

    researchmap

  • Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model

    Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   40 ( 1 )   214 - 224   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SAGE PUBLICATIONS INC  

    The ubiquitin-proteasome system (UPS) and autophagy are two major pathways to degrade misfolded proteins that accumulate under pathological conditions. When UPS is overloaded, the degeneration pathway may switch to autophagy to remove excessive misfolded proteins. However, it is still unclear whether and how this switch occurs during cerebral ischemia. In the present study, transient middle cerebral artery occlusion (tMCAO) resulted in accelerated ubiquitin-positive protein aggregation from 0.5 h of reperfusion in mice brain after 10, 30 or 60 min of tMCAO. In contrast, significant reduction of p62 and induction of LC3-II were observed, peaking at 24 h of reperfusion after 30 and 60 min tMCAO. Western blot analyses showed an increase of BAG3 and HDAC6 at 1 or 24 h of reperfusion that was dependent on the ischemic period. In contract, BAG1 decreased at 24 h of reperfusion after 10, 30 or 60 min of tMCAO after double immunofluorescent colocalization of ubiquitin, HSP70, p62 and BAG3. These data suggest that a switch from UPS to autophagy occurred between 10 and 30 min of cerebral ischemia depending on the BAG1/BAG3 ratio and level of HDAC6.

    DOI: 10.1177/0271678X18810617

    Web of Science

    researchmap

  • A dramatic increase in serum CK levels after switching from oral to intravenous administration of LEV

    Mami Takemoto, Taijun Yunoki, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Jingwei Shang, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   8 ( 1 )   39 - 41   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    The authors report on a 22-year-old Japanese woman who started oral administration of 1000 mg levetiracetam (LEV) for her epilepsy after the second convulsive seizure. She was free from seizures for the subsequent 111 days, but a third tonic-clonic seizure happened and she was transferred to our hospital (Day 1). Her consciousness state was drowsy and 1000 mg LEV continued for two days, but intravenously. Although her state became clear, her serum creatine kinase (CK), myoglobin (Mb), and creatine (Cre) levels were significantly elevated (18 179 IU/L, 2783 ng/mL, and 0.8 mg/mL) with a peak at Day 5 of CK 26, 189 IU/L. After stopping intravenous injection of LEV, serum CK returned to its normal level promptly. The present case suggests that we should take more care in monitoring for rhabdomyolysis on switching from oral to intravenous administration of LEV.

    DOI: 10.1111/ncn3.12336

    Web of Science

    researchmap

  • A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology

    Koji Abe, Jinwei Shang, Xiaowen Shi, Toru hita Yamas, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Liang-Ja Lee, Kenji Tanaka

    JOURNAL OF ALZHEIMERS DISEASE   73 ( 1 )   217 - 227   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOS PRESS  

    Background: Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer's disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid-beta(A beta), plasma tau, and serum antibodies for A beta(1-42 )are not yet well established.Objective: We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology.Methods: With only 1.5 mu l of serum, we examined a new target plate "BLOTCHIP (R)" plus a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n = 100), MCI (n = 60), and AD (n = 99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains.Results: Apart from A beta or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (***p < 0.001). MMSE score was well correlated to brain A beta deposition and to SPD of AD. The mother proteins of the four peptides were upregulated for coagulation, complement, and plasticity (three proteins), and was downregulated for anti-inflammation (one protein) in AD brains.Conclusion: The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage.

    DOI: 10.3233/JAD-191016

    Web of Science

    researchmap

  • A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology

    Koji Abe, Jingwei Shang, Xiaowen Shi, Toru Yamashita, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Lyang Ja Lee, Kenji Tanaka

    Journal of Alzheimer's Disease   73 ( 1 )   217 - 227   2020

     More details

    Publishing type:Research paper (scientific journal)  

    © 2020-IOS Press and the authors. All rights reserved. Background: Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer's disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid-β (Aβ), plasma tau, and serum antibodies for Aβ1-42 are not yet well established. Objective: We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology. Methods: With only 1.5μl of serum, we examined a new target plate 'BLOTCHIP®' plus a matrix-Assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n=100), MCI (n=60), and AD (n=99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains. Results: Apart from Aβ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (∗∗∗p<0.001). MMSE score was well correlated to brain Aβ deposition and to SPD of AD. The mother proteins of the four peptides were upregulated for coagulation, complement, and plasticity (three proteins), and was downregulated for anti-inflammation (one protein) in AD brains. Conclusion: The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage.

    DOI: 10.3233/JAD-191016

    Scopus

    PubMed

    researchmap

  • The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP). International journal

    Mami Takemoto, Yasuyuki Ohta, Nozomi Hishikawa, Toru Yamashita, Emi Nomura, Keiichiro Tsunoda, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Yoshio Omote, Koji Abe

    Journal of Alzheimer's disease : JAD   76 ( 2 )   769 - 772   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life. OBJECTIVE: We aimed to determine the efficacy of two antidepressants and one antipathy drug in the treatment of depression and apathy in AD patients. METHODS: In the present study, we evaluated the efficacy of sertraline (n = 11; average dose = 31.8 mg), escitalopram (n = 13; average dose = 7.3 mg), and nicergoline (n = 9; average dose = 14.5 mg) in treating depression and apathy over a period of 3 months (M).The 33 patients with AD demonstrated high Geriatric Depression Scale (GDS) (>5) or a high Apathy Scale (AS) (>16) scores. RESULTS: The patients receiving escitalopram treatment showed a significant improvement in GDS score from baseline (8.2±3.5) to 3 M (5.7±2.6, p = 0.04), and the patients receiving sertraline treatment showed a significant improvement in AS score from baseline (20.8±5.2) to 3 M (16.8±6.1, p = 0.05); however, no significant changes were noted in patients receiving nicergoline. CONCLUSION: These results provide novel information on the efficacy of sertraline and escitalopram in the treatment of apathy and depression, respectively, in patients with AD.

    DOI: 10.3233/JAD-200247

    PubMed

    researchmap

  • A Polyphenolic Complex Attenuates Inflammatory Response and Blood- Brain Barrier Disruption. International journal

    Yuting Bian, Toru Yamashita, Yuki Taira, Jingwei Shang, Keiichiro Tsunoda, Tian Feng, Ryo Sasaki, Xia Liu, Xiaowen Shi, Koh Tadokoro, Emi Nomura, Namiko Matsumoto, Yusuke Osakada, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    Current neurovascular research   17 ( 3 )   286 - 293   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Cerebral ischemia causes a strong inflammatory response. Neumentix is a dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic content, which has been proved to be beneficial against inflammatory response. Therefore, Neumentix's effect on anti-inflammatory and blood brain barrier (BBB) disruption in transient middle cerebral artery occlusion (tMCAO) model mice is investigated in this study. METHODS: After the pretreatment of vehicle or Neumentix 134 mg/kg/d, intraperitoneal injection (i.p.) (containing rosmarinic acid 20 mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and kept receiving vehicle or Neumentix daily 5 days afterward. RESULTS: Neumentix treatment ameliorated neurobehavioral impairment in the corner test (5d after tMCAO, **P<0.01), reduced infarct volume (#P<0.05), suppressed expression of ionized calciumbinding adapter molecule-1 (Iba-1), tumor necrosis factor alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) (###P<0.001), and improved the integrity of BBB (§P<0.05) at 5 days after tMCAO. CONCLUSION: The present study provided an evidence of Neumentix's anti-inflammatory and neuroprotection effect against BBB disruption on experimental tMCAO model mice, suggesting that Neumentix could be a potential therapeutic agent for stroke.

    DOI: 10.2174/1567202617666200517105727

    PubMed

    researchmap

  • Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment

    Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Ryuta Morihara, Yumiko Nakano, Yoshiaki Takahashi, Noriko Hatanaka, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF ALZHEIMERS DISEASE   73 ( 1 )   209 - 215   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOS PRESS  

    The world is rapidly aging and facing an increase in the number of dementia patients, so it is important to detect the preclinical stage of dementia in such countries. We examined both cognitive and affective functions among cognitively normal control (n = 218), mild cognitive impairment (MCI, n = 146), and Alzheimer's disease (AD, n = 305) subjects using two evaluation tools for behavioral and psychological symptoms of dementia (BPSD) [Abe's BPSD score (ABS) and mild behavioral impairment (MBI)]. BPSD were present in 12.4% (ABS) and 9.6% (MBI) of cognitively normal people, 34.9% and 32.2% in MCI subjects, and 66.2% and 51.1% in AD patients. Both ABS (p < 0.05) and MBI (( )p < 0.01) score showed worse score with cognitive decline of the Mini-Mental State Examination in the AD group in BPSD-positive participants. Similar correlations were found in all participants in AD group ((parallel to parallel to)p < 0.01 versus ABS and MBI). Among the subscales in BPSD-positive participants, an apathy/indifference score of ABS and a decreased motivation of MBI showed significant differences in AD patients compared to the control and MCI subjects (**p < 0.01). In addition, subscale analyses further showed a downward trend from the control to MCI and AD subjects in four ABS subscales and three MBI subscales. The present study showed the preclinical presence of BPSD in cognitively normal people, more so in MCI subjects, and ABS detected BPSD more sensitively than MBI in all three groups.

    DOI: 10.3233/JAD-190669

    Web of Science

    researchmap

  • Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease

    Yasuyuki Ohta, Emi Nomura, Noriko Hatanaka, Yosuke Osakada, Namiko Matsumoto, Ryo Sasaki, Keiichiro Tsunoda, Mami Takemoto, Koh Tadokoro, Nozomi Hishikawa, Yosuke Wakutani, Toru Yamashita, Kota Sato, Yoshio Omote, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   70   96 - 101   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Associations of sarcopenia and physical frailty in cognitive and affective (depression, apathy, and behavioral and psychological symptoms of dementia) functions of mild cognitive impairment (MCI) and Alzheimer's disease (AD) were not fully evaluated previously, especially not for gender differences. 165 AD, 84 MCI, and 48 control participants (175 female, 122 male) were evaluated for cognitive, affective, activities of daily living (ADL), and physical functions associated with sarcopenia and physical frailty. In both sexes, cognitive and affective functions, ADL, and physical functions worsened in MCI and AD compared to control subjects. Physical dysfunctions, especially slow gait speed (3 m up and go test), were significantly associated with cognitive, affective, and ADL declines in participants (control subjects, MCI, and AD) of each gender, which were especially noticeable in females. The present study may be the first to suggest significant associations of sarcopenia and physical frailty with cognitive and affective functions of MCI and AD, especially in females. (C) 2019 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2019.08.062

    Web of Science

    researchmap

  • Intracranial invasive fungal aneurysm due to Aspergillus sinusitis successfully treated by voriconazole plus internal carotid artery ligation therapy in an aged woman

    Mami Takemoto, Yasuyuki Ohta, Koh Tadokoro, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Toru Yamashita, Nozomi Hishikawa, Jingwei Shang, Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Isao Date, Koji Abe

    NEUROLOGY ASIA   24 ( 4 )   363 - 367   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ASEAN NEUROLOGICAL ASSOC  

    A fungal carotid aneurysm is an infrequently occurring infectious aneurysm that is usually treated by antifungal therapy plus surgical debridement of the infected vessel. We herein report an extremely rare case involving a patient with a medical history of bladder cancer treated by Bacillus Calmette-Guerin (BCG) who developed a fungal aneurysm of the internal carotid artery and thrombosis of the superior ophthalmic vein caused by maxillary Aspergillus sinusitis. The patient was successfully treated by antifungal, anticoagulant, and antiplatelet drugs combined with internal carotid artery ligation therapy. Internal carotid artery fungal aneurysm is associated with a high mortality rate, but the present case suggests that it can be successfully treated by antifungal therapy combined with a less invasive endovascular therapy.

    Web of Science

    researchmap

  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people

    Nozomi Hishikawa, Yoriko Takahashi, Yusuke Fukui, Ryo Tokuchi, Junichi Furusawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    Neurological Research   41 ( 11 )   1001 - 1007   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga (‘Yoga-plus’) among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise program at a health and welfare center, a day service center, and a nursing home. Cognitive, affective, and physical functions, and activities of daily living (ADL), were compared at baseline (0M), 6M and 12M of exercise intervention. Results: Mean scores on the frontal assessment battery, clock drawing test, cube copying test, letter fluency, and category fluency significantly improved after the Yoga-plus intervention, while mini-mental state examination, Hasegawa dementia score-revised, and trail-making test performance were relatively stable. Affective scores on the geriatric depression scale (GDS), apathy scale (AS) and Abe’s behavioral and psychological symptoms of dementia were not significantly affected by exercise therapy, but subgroups with higher baseline GDS (GDS ≥ 5) and AS (AS ≥ 16) scores showed a significant improvement after intervention. One-leg standing time and 3-m timed up and go test performance significantly improved after 12M intervention. Discussion: Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals.

    DOI: 10.1080/01616412.2019.1672380

    Scopus

    PubMed

    researchmap

  • Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction.

    Ryo Sasaki, Yasuyuki Ohta, Kota Sato, Koh Tadokoro, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hiroyuki Ishiura, Shoji Tsuji, Koji Abe

    Internal medicine (Tokyo, Japan)   58 ( 21 )   3163 - 3165   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.

    DOI: 10.2169/internalmedicine.2765-19

    PubMed

    researchmap

  • パーキンソン病とレビー小体型認知症の検査所見やmicrobleeds出現頻度の違いについて

    武本 麻美, 佐藤 恒太, 太田 康之, 山下 徹, 菱川 望, 阿部 康二

    臨床神経学   59 ( Suppl. )   S266 - S266   2019.11

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 時間で追う脳虚血の病態と治療:(2)亜急性期 虚血脳内グリア細胞から神経細胞を誘導するダイレクトリプログラミング法の確立

    山下 徹, 商 敬偉, 中野 由美子, 森原 隆太, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    脳循環代謝   31 ( 1 )   65 - 65   2019.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • Chronic cerebral hypoperfusion alters amyloid-beta transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse

    Jingwei Shang, Tom Yamashita, Feng Tian, Xianghong Li, Xia Liu, Xiaowen Shi, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Ryo Sasaki, Koh Tadokoro, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    BRAIN RESEARCH   1723   146379 - 146379   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Abnormal accumulation of amyloid-beta (A beta) peptide defines progression of Alzheimer's disease (AD) pathology in brain. Here, we investigated expressive changes of two main All transport receptors low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE) in a novel AD mice (APP23) with chronic cerebral hypoperfusion (CCH) model, moreover, examined a protective effect of a free radical scavenger edaravone (Eda). In contrast to wild type (WT) and APP23 mice, CCH strongly accelerated abnormal A beta 40 depositions and cerebral amyloid angiopathy (CAA) pathology, increased both LRP1 and RAGE expressions in brain parenchyma, while a decrease of LRP1 and an increase of RAGE were observed in vascular endothelial cells at age 12 months (M) of AD mice. Furthermore, CCH strongly increased expressions of two hypoxia-related proteins hypoxia inducible factor-1 alpha (HIF-1 alpha) and heme oxygenase-1 (HO-1), two oxidative-related proteins 4-hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and decreased both two vital nutrient transporter proteins major facilitator super family domain containing 2a (Mfsd2a) and glucose transporter 1 (Glut1) expressions. Such the above abnormal pathological changes were significantly ameliorated by edaravone treatment. The present study demonstrated that CCH strongly enhanced primary AD pathology causing double imbalances of A beta efflux and influx transport related proteins in the cortical blood vessels in AD mice, and that such a neuropathologic abnormality was greatly ameliorated by Eda.

    DOI: 10.1016/j.brainres.2019.146379

    Web of Science

    researchmap

  • A unique stroke case with contralateral sulcal hyperintensity on fluid-attenuated inversion recovery image changed to linear serpiginous structures

    Yosuke Osakada, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   7 ( 6 )   351 - 353   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    An 83-year-old man developed acute ischemic stroke. Brain magnetic resonance imaging (MRI) showed ischemic stroke in the left parietal lobe gyri, but fluid-attenuated inversion recovery (FLAIR) showed hyperintensity in the contralateral right temporal-occipital lobe sulci. Follow-up FLAIR image showed the gradual disappearance of the sulcal hyperintensity in the sulci and changed to linear serpiginous structures. This is a unique stroke case showing transitioned FLAIR findings suggesting that the sulcal hyperintensity findings are more severe and an earlier ischemic condition than the linear serpiginous structures.

    DOI: 10.1111/ncn3.12327

    Web of Science

    researchmap

  • Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people

    Nozomi Hishikawa, Yoriko Takahashi, Yusuke Fukui, Ryo Tokuchi, Junichi Furusawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGICAL RESEARCH   41 ( 11 )   1001 - 1007   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:TAYLOR & FRANCIS LTD  

    Objectives: Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga (?Yoga-plus?) among elderly individuals. Methods: A total of 385 subjects (72 males and 313 females, 75.5 ? 8.7 years old) participated in a 12-month (M) exercise program at a health and welfare center, a day service center, and a nursing home. Cognitive, affective, and physical functions, and activities of daily living (ADL), were compared at baseline (0M), 6M and 12M of exercise intervention. Results: Mean scores on the frontal assessment battery, clock drawing test, cube copying test, letter fluency, and category fluency significantly improved after the Yoga-plus intervention, while mini-mental state examination, Hasegawa dementia score-revised, and trail-making test performance were relatively stable. Affective scores on the geriatric depression scale (GDS), apathy scale (AS) and Abe?s behavioral and psychological symptoms of dementia were not significantly affected by exercise therapy, but subgroups with higher baseline GDS (GDS ? 5) and AS (AS ? 16) scores showed a significant improvement after intervention. One-leg standing time and 3-m timed up and go test performance significantly improved after 12M intervention. Discussion: Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals.

    DOI: 10.1080/01616412.2019.1672380

    Web of Science

    researchmap

  • 筋萎縮性側索硬化症患者の前頭葉機能の特徴

    太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 表 芳夫, 阿部 康二

    Dementia Japan   33 ( 4 )   529 - 529   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本認知症学会  

    researchmap

  • アルツハイマー病の進行に関する臨床的予測因子(Clinical predictors of Alzheimer's disease progression)

    菱川 望, 表 芳夫, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    Dementia Japan   33 ( 4 )   523 - 523   2019.10

     More details

    Language:English   Publisher:(一社)日本認知症学会  

    researchmap

  • 多発性の大脳・脳幹病変を認め、診断及び治療に苦慮した抗MOG抗体関連症候群の1例

    松本 菜見子, 佐藤 恒太, 河原 由子, 武本 麻美, 菱川 望, 表 芳夫, 商 敬偉, 太田 康之, 山下 徹, 藤井 謙太郎, 黒住 和彦, 伊達 勲, 阿部 康二

    神経治療学   36 ( 6 )   S251 - S251   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • Sleep problems in subacute myelo-optico neuropathy (SMON)

    Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   68   128 - 133   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Subacute myelo optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 <= Athens Insomnia Scale score) was 89.6% among SMON patients, which was significantly higher than among control participants 54.4%. Sleep quality measured with the Pittsburgh Sleep Quality Index (PSQI) revealed that the prevalence of poor sleepers (6 <= PSQI score) was higher among SMON patients than control participants (75.6% vs 39.6%, respectively). Subscale analyses of rapid eye movement sleep behavior disorder screening questionnaire revealed that scores on two items ("dreams match nocturnal behavior" and "limb movements") were significantly higher among SMON patients than control participants. In addition, daytime sleepiness scores were significantly higher among SMON patients than control participants (4 <= Epworth Sleepiness Scale scores: 54.0% vs 29.0%, respectively). The current study revealed that most SMON patients suffer from insomnia with dissatisfactory sleep quality, likely due to their long-term physical sequelae. Moreover, SMON patients showed higher rates of daytime sleepiness and sleep medication intake, which could be related to reduced activity during the day, as well as insomnia. (C) 2019 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2019.07.013

    Web of Science

    researchmap

  • Sleep problems in subacute myelo-optico neuropathy (SMON)

    Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

    Journal of Clinical Neuroscience   68   128 - 133   2019.10

     More details

    Publishing type:Research paper (scientific journal)  

    © 2019 Elsevier Ltd Subacute myelo-optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 ≤ Athens Insomnia Scale score) was 89.6% among SMON patients, which was significantly higher than among control participants 54.4%. Sleep quality measured with the Pittsburgh Sleep Quality Index (PSQI) revealed that the prevalence of poor sleepers (6 ≤ PSQI score) was higher among SMON patients than control participants (75.6% vs 39.6%, respectively). Subscale analyses of rapid eye movement sleep behavior disorder screening questionnaire revealed that scores on two items (“dreams match nocturnal behavior” and “limb movements”) were significantly higher among SMON patients than control participants. In addition, daytime sleepiness scores were significantly higher among SMON patients than control participants (4 ≤ Epworth Sleepiness Scale scores: 54.0% vs 29.0%, respectively). The current study revealed that most SMON patients suffer from insomnia with dissatisfactory sleep quality, likely due to their long-term physical sequelae. Moreover, SMON patients showed higher rates of daytime sleepiness and sleep medication intake, which could be related to reduced activity during the day, as well as insomnia.

    DOI: 10.1016/j.jocn.2019.07.013

    Scopus

    PubMed

    researchmap

  • Twendee X Ameliorates Phosphorylated Tau, alpha-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion

    Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   28 ( 10 )   104310 - 104310   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and alpha-synudein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX). Methods: APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradually decrease the cerebral blood flow. The effects of the administration of TwX were evaluated by immunohistochemical analysis and Immunofluorescent histochemistry. Results: The present study revealed that the expressions of phospho-tau and phospho-alpha-synudein were significantly increased in the APP23 + CCH mice group as compared with wild type and APP23 mice groups (*P < .05 and **P < .01 versus WT; P-# < .05 and (##) P < .01 versus APP23). In addition, CCH significantly exacerbated MMP-9 activation relating to blood-brain barrier destruction (*P < .01 versus WT; (#) P < .05, and (##) P < .01 versus APP23), enhanced neurovascular remodeling, and impaired a neurovascular trophic coupling in the vascular endothelial BDNF expression of the APP23 + CCH group. TwX treatment (20 mg/kg/ day, from 4.5 to 12 months) significantly reduced tau and oc-synudein pathologies, ameliorated neurovascular dysfunction compared with APP23 + CCH group. Conclusions: Our findings indicate that administration of a new antioxidative mixture TwX substantially reduced the above neuropathologic abnormalities, suggesting a potential therapeutic benefit of TwX for AD with CCH.

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.104310

    Web of Science

    researchmap

  • 胃瘻造設後に高浸透圧高血糖症候群を発症した進行性核上性麻痺の1例

    田所 功, 佐藤 恒太, 森原 隆太, 商 敬偉, 武本 麻美, 表 芳夫, 太田 康之, 山下 徹, 菱川 望, 阿部 康二

    神経治療学   36 ( 6 )   S269 - S269   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice

    Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    NEUROSCIENCE   416   126 - 136   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Alzheimer's disease (AD) in the elderly is frequently accompanied by chronic cerebral hypoperfusion (CCH), which impairs the clearance of amyloid beta (A beta) due to the dysfunction of the blood-brain barrier (BBB) and accelerates the AD pathology. Since the coagulation and complement cascades are associated with BBB dysfunction and AD pathology, we investigated the expression changes of coagulation (fibrinogen alpha chain-FGA, coagulation factor XIII A chain-Factor XIII alpha) and complement (plasma protease C1 inhibitor-C1-INH, Complement component 3-C3) factors in the brain of novel AD model (APP23) mice with CCH at 12 months of age. Immunohistochemical and immunofluorescent analysis showed that the expressions of FGA, Factor XIII alpha, C1-INH and C3 were significantly increased in cerebral neocortex, hippocampus, and thalamus of APP23 + CCH group (n = 12) as compared with wild type (WT, n = 10) and APP23 (n = 10) groups (*P < . 05 and ** P < .01 vs WT; P-# < .05 and P-## < .01 vs APP23), especially near and inside of neurovascular unit. The present study suggests that CCH activated both the coagulation and complement cascades in a novel AD model mice brain accompanied by the acceleration of AD pathology. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.neuroscience.2019.07.050

    Web of Science

    researchmap

  • Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis

    Yumiko Nakano, Keiichiro Tsunoda, Toru Yamashita, Jun Mitsui, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Tatsushi Toda, Shoji Tsuji, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   7 ( 5 )   288 - 290   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We found a late presented congenital myasthenic syndrome (CMS) patient with novel CHRNE gene mutations. Although our patient has shown blepharoptosis since youth, fatigable muscle weakness began at age 71. Genetic analysis revealed novel compound heterozygous CHRNE mutations (c.1032+2T>G, c.1306_1307 delGA). His myasthenic symptoms were well managed by oral anti-cholinesterase drug until he died at 82-year-old. The present case showed mild myasthenic symptoms with very late presentation and slow progression. Late presented CMS is often underdiagnosed; therefore, genetic testing is important to distinguish it from other myasthenic disease.

    DOI: 10.1111/ncn3.12317

    Web of Science

    researchmap

  • Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model

    Emi Nomura, Yasuyuki Ohta, Koh Tadokoro, Jingwei Shang, Tian Feng, Xia Liu, Xiaowen Shi, Namiko Matsumoto, Ryo Sasaki, Keiichiro Tsunoda, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Koji Abe

    NEUROSCIENCE   415   31 - 43   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Hypoxia inducible factor-1 alpha (HIF-1 alpha) is a key transcription factor that maintains oxygen homeostasis. Hypoxic stress is related to the pathogenesis of amyotrophic lateral sclerosis (ALS), and impaired HIF-1 alpha induces motor neuron degeneration in ALS. Dimethyloxalylglycine (DMOG) upregulates the stability of HIF-1 alpha expression and shows neuroprotective effects, but has not been used in ALS as an anti-hypoxic stress treatment. In the present study, we investigated hypoxic stress in ALS model mice bearing G93A-human Cu/Zn superoxide dismutase by in vivo HIF-1 alpha imaging, and treated the ALS mice with DMOG. In vivo HIF-1 alpha imaging analysis showed enhanced hypoxic stress in both the spinal cord and muscles of lower limbs of ALS mice, even at the pre-symptomatic stage. HIF-1 alpha expression decreased as the disease progressed until 126 days of age. DMOG treatment significantly ameliorated the decrease in HIF-1 alpha expression, the degeneration of both spinal motor neurons and myofibers in lower limbs, gliosis and apoptosis in the spinal cord. This was accompanied by prolonged survival. The present study suggests that in vivo bioluminescence resonance energy transfer (BRET) HIF-1 alpha imaging is useful for evaluating hypoxic stress in ALS, and that the enhancement of HIF-1 alpha is a therapeutic target for ALS patients. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.neuroscience.2019.06.025

    Web of Science

    researchmap

  • A Japanese patient with a VCP mutation c.290G > A (p.G97E) presenting a rapid progressive respiratory failure.

    Nomura E, Ohta Y, Sato K, Kawahara Y, Takemoto M, Takahashi Y, Matsumoto N, Yunoki T, Yamashita T, Hishikawa N, Nishino I, Abe K

    Neuro Clin Neurosci   7 ( 6 )   361 - 364   2019.8

     More details

    Language:English  

    researchmap

  • A Unique Recurrent Stroke Case due to Bilateral Vertebral Artery Dissection with Familial Hirschsprung Disease

    Kota Sato, Ryo Sasaki, Yasuyuki Ohta, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   28 ( 8 )   e113 - e115   2019.8

     More details

    Publishing type:Research paper (scientific journal)  

    © 2019 Elsevier Inc. Vertebral artery (VA) dissection is one major cause of brain infarction in young and middle-aged adults. Risk factors for VA dissection are hypertension, diabetes mellitus, hyperlipidemia, trauma, and genetic factors. A 32-year-old man with familial Hirschsprung disease at the age of 2 presented cerebellar ischemic stroke due to bilateral VA dissections. A stroke recurred within 17 days despite oral dual antiplatelet therapy. Bilateral VA dissections and recurrent dissections are related to genetic mutations associated with connective tissue diseases. A part of familial Hirschsprung disease has genetic factors in common with cerebrovascular disease. There may be a common genetic background between his VA dissection and Hirschsprung disease.

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.04.035

    Scopus

    PubMed

    researchmap

  • Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion

    Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   28 ( 7 )   1993 - 2002   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: Multiple pathogeneses are involved in Alzheimer's disease (AD), such as amyloid-beta accumulation, neuroinflammation, and oxidative stress. The pathological impact of chronic cerebral hypoperfusion on Alzheimer's disease is still poorly understood. Methods: APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive chronic cerebral hypoperfusion (CCH). The effects of the administration of Twendee X (TwX) were evaluated by behavioral analysis, immunohistochemical analysis, and immunofluorescent histochemistry. Results: In the present study, chronic cerebral hypoperfusion, which is commonly found in aged Alzheimer's disease, significantly exacerbated motor dysfunction of APP23 mice from 5 months and cognitive deficit from 8 months of age, as well as neuronal loss, extracellular amyloid-beta plaque and intracellular oligomer formations, and amyloid angiopathy at 12 months. Severe upregulations of oxidative markers and inflammatory markers were found in the cerebral cortex, hippocampus, and thalamus at 12 months. Twendee X treatment (20 mg/kg/d, from 4.5 to 12 months) substantially rescued the cognitive deficit and reduced the above amyloid-b pathology and neuronal loss, alleviated neuroinflammation and oxidative stress. Conclusions: The present findings suggested a potential therapeutic benefit of Twendee X for Alzheimer's disease with chronic cerebral hypoperfusion.

    DOI: 10.1016/j.jstrokecerebrovasdis.2019.03.029

    Web of Science

    researchmap

  • In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia

    Toru Yamashita, Jingwei Shang, Yumiko Nakano, Ryuta Morihara, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    SCIENTIFIC REPORTS   9 ( 1 )   10956 - 10956   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5-2.0 x 10(7) /ul) of mock pMX-GFP (n = 13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n = 14) was directly injected into the ipsilateral striatum and cortex 3 days after 30 min of transient cerebral ischemia. The reprogrammed cells first expressed neuronal progenitor marker Dcx 7 and 21 days after viral injection, then expressed mature neuronal marker NeuN. This was accompanied by morphological changes, including long processes and synapse-like structures, 49 days after viral injection. Meanwhile, therapeutic improvement was not detected both in clinical scores or infarct volume. The present study provides a future novel self-repair strategy for ischemic stroke with beneficial modifications of the inducer-suppressor balance.

    DOI: 10.1038/s41598-019-47482-0

    Web of Science

    researchmap

  • A pneumococcal meningoencephalitis with a small spleen

    Keiichiro Tsunoda, Kota Sato, Yoshiaki Takahashi, Koh Tadokoro, Ryo Sasaki, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   7 ( 4 )   215 - 217   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Streptococcus pneumoniae is a major cause of bacterial meningitis usually in children or elder adults. We report a case of a 38-year-old man having pneumococcal meningoencephalitis with a small spleen (35 cm(3)), compared to seven previous patients with pneumococcal meningitis in our department. Among the eight patients, four cases were due to sinusitis, but the origin could not be identified in the other four cases, including the present case who was the youngest patient with the smallest splenic size. Of interest in the present analysis was the negative or positive correlation between splenic size and age, with or without sinusitis. This is the first report on pneumococcal meningoencephalitis that takes into consideration age, splenic size, and the origin of infection.

    DOI: 10.1111/ncn3.12290

    Web of Science

    researchmap

  • Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse

    Jingwei Shang, Toru Yamashita, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Xianghong Li, Feng Tian, Xia Liu, Yong Huang, Xiaowen Shi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROSCIENCE RESEARCH   143   61 - 70   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Cerebral neuroinflammation defines a novel pathway for progressing Alzheimer's disease (AD) pathology. We investigated immunohistological changes of neuroinflammation with nucleotide-binding domain and leucine-rich repeat (NLR)-protein 3 (NLRP3), activated caspase-1 and interleukin-1 beta (IL-1 beta) in a novel AD (APP23) mice with chronic cerebral hypoperfusion (CCH) model from 4 months (M) of age, moreover, examined protective effect of galantamine. CCH strongly enhanced NLRP3, activated caspase-1 and IL-1 beta expressions in hippocampus and thalamus at age 12 M of AD mice. CCH also exaggerated amyloid-beta (A beta) 40 depositions in cerebral cortex. Furthermore, CCH exacerbated a marked dissociation of neurovascular unit (NVU). These pathological changes were ameliorated by galantamine treatment. The present study demonstrated that CCH strongly enhanced primary AD pathology including neuroinflammation, A beta accumulations and NVU dissociation in AD mice, which was greatly protected by an allosterically potentiating ligand galantamine. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

    DOI: 10.1016/j.neures.2018.06.002

    Web of Science

    researchmap

  • Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis

    Yasuyuki Ohta, Emi Nomura, Jingwei Shang, Tian Feng, Yong Huang, Xia Liu, Xiaowen Shi, Yumiko Nakano, Nozomi Hishikawa, Kota Sato, Mami Takemoto, Toru Yamashita, Koji Abe

    JOURNAL OF NEUROSCIENCE RESEARCH   97 ( 5 )   607 - 619   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but the neuroprotective mechanism for the oxidative stress of ALS has not been fully investigated. In this study, we investigated oxidative stress in ALS model mice bearing both oxidative stress sensor nuclear erythroid 2-related factor 2 (Nrf2) and G93A-human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. In vivo Nrf2 imaging analysis showed the accelerated oxidative stress both in spinal motor neurons and lower limb muscles of Nrf2/G93A mice according to disease progression in addition to the enhancement of serum oxidative stress marker dROMS. These were significantly alleviated by edaravone treatment accompanied by clinical improvements (rotarod test). The present study suggests that in vivo optical imaging of Nrf2 is useful for detecting oxidative stress in ALS, and edaravone alleviates the degeneration of both motor neurons and muscles related to oxidative stress in ALS patients.

    DOI: 10.1002/jnr.24368

    Web of Science

    researchmap

  • Very rare solitary primary peripheral nerve onset cytotoxic molecule-positive peripheral T-cell lymphoma (PTCL)

    Namiko Matsumoto, Kota Sato, Yoshiaki Takahashi, Yuko Kawahara, Taijun Yunoki, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Maiko Sakamoto, Eisei Kondou, Rei Shibata, Tadashi Yoshino, Toshifumi Ozaki, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   7 ( 3 )   146 - 149   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Here we present the first report of solitary primary peripheral nerve onset cytotoxic molecule (CM)-positive peripheral T-cell lymphoma (PTCL) diagnosed after nerve biopsy. An 84-year-old female with rheumatoid arthritis (RA) complained of asymmetric severe tenderness in her upper limbs. The biopsy pathology revealed a direct invasion of CM-positive PTCL. When RA patients complain of numbness, tenderness, or weakness, lymphomatic peripheral nerve invasion should be considered.

    DOI: 10.1111/ncn3.12280

    Web of Science

    researchmap

  • Multi-modal combination therapy rescued a frequent ischemic stroke patient due to giant cell arteritis Reviewed

    Yoshiaki Takahashi, Kota Sato, Namiko Matsumoto, Yuko Kawahara, Taijun Yunoki, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   7 ( 3 )   132 - 135   2019.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Ischemic stroke (IS) due to giant cell arteritis (GCA) is rare, but highly mortal. Here, we report a 72-year-old man who showed frequent IS with GCA. Initial therapy with prednisolone increased the frequency of IS, which disappeared after continuous multi-modal combination therapy with corticosteroids, immunosuppressive agents, antiplatelets, and statin. The present case was discharged with independent walk, suggesting that a multi-modal combination therapy rescued the GCA patient from frequent IS.

    DOI: 10.1111/ncn3.12266

    Web of Science

    researchmap

  • Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C.

    Namiko Matsumoto, Yasuyuki Ohta, Kentaro Deguchi, Masayuki Kishida, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Aki Watanabe, Koutaro Yokote, Minoru Takemoto, Junko Oshima, Koji Abe

    Internal medicine (Tokyo, Japan)   58 ( 7 )   1033 - 1036   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN gene (WRN). Most Japanese WS patients are born from a consanguineous marriage with homozygous WRN mutations. We herein report a rare WS patient born from non-consanguineous parents with compound heterozygous WRN mutations with a novel heterogeneous c.1720+1G>A substitution plus the most frequent heterogeneous c.3139-1G>C substitution among Japanese. Although the present case showed clinical characteristics common to previous Japanese WS patients, he had not developed any malignant tumors as of 43 years of age, suggesting that WS patients with this particular genetic mutation have a different phenotype than others.

    DOI: 10.2169/internalmedicine.1816-18

    PubMed

    researchmap

  • A Japanese family of autosomal dominant cerebral small vessel disease with heterozygous HTRA1 mutation showing dementia, gait disturbance and subarachnoid hemorrhage.

    Yamashita T, Nozaki H, Wakutani Y, Tadokoro K, Nomura E, Takahashi Y, Sato K, Hishikawa N, Takemoto M, Shang J, Ohta Y, Onodera O, Abe K

    Vas-Cog Journal   5   20 - 26   2019.4

     More details

    Language:English  

    researchmap

  • Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model

    Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toni Yamashita, Koji Abe

    JOURNAL OF ALZHEIMERS DISEASE   68 ( 4 )   1667 - 1675   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOS PRESS  

    Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novel AD model (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 + HP group (n = 12) than the simple APP23 (n =10) group (*p < 0.05 and **p < 0.01 versus WT; (#)p < 0.05 and (##)p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF alpha-dependent AHSG in a novel AD plus HP mice model.

    DOI: 10.3233/JAD-181218

    Web of Science

    researchmap

  • A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy

    Ryo Sasaki, Yasuyuki Ohta, Yoshiaki Takahashi, Keiichiro Tsunoda, Koh Tadokoro, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Tom Yamashita, Koji Abe

    INTERNAL MEDICINE   58 ( 3 )   437 - 440   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Klinefelter syndrome is a chromosomal disorder with a typical karyotype of 47, XXY, accompanied by various neurological symptoms. We herein report the first case of Klinefelter syndrome with a rare mosaic form of 47, XXY and 48, XXXY, combined with both spastic paraplegia and peripheral motor neuropathy. This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities. A motor nerve conduction study and the magnetic motor evoked potential suggested motor axonal neuropathy and corticospinal tract disorders. The present case suggests that Klinefelter syndrome can present with both upper and lower motor neuron degeneration.

    DOI: 10.2169/internalmedicine.1048-18

    Web of Science

    researchmap

  • Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study

    Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, Nozomi Hishikawa, Satoko Kawano, Ryo Sasaki, Namiko Matsumoto, Emi Nomura, Yumiko Nakano, Yoshiaki Takahashi, Mami Takemoto, Toru Yamashita, Setsuko Ueno, Yosuke Wakutani, Yoshiki Takao, Nobutoshi Morimoto, Yumiko Kutoku, Yoshihide Sunada, Katsushi Taomoto, Yasuhiro Manabe, Kentaro Deguchi, Yasuto Higashi, Haruhiko Inufusa, Fukka You, Toshikazu Yoshikawa, Markus Matuschka von Greiffenclau, Koji Abe

    JOURNAL OF ALZHEIMERS DISEASE   71 ( 3 )   1063 - 1069   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOS PRESS  

    Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n= 37) and TwX (n= 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.

    DOI: 10.3233/JAD-190644

    Web of Science

    researchmap

  • Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma

    Yasuyuki Ohta, Yuko Kawahara, Koh Tadokoro, Kota Sato, Ryo Sasaki, Yoshiaki Takahashi, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takeru Asano, Tomoko Inomata, Koji Abe

    INTERNAL MEDICINE   58 ( 2 )   283 - 286   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and F-18-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient's serum was positive for anti-sulfated glucuronyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies.

    DOI: 10.2169/internalmedicine.1269-18

    Web of Science

    researchmap

  • Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service

    Yasuyuki Ohta, Nozomi Hishikawa, Kota Sato, Mami Takemoto, Tom Yamashita, Shinji Doutare, Koji Abe

    INTERNAL MEDICINE   58 ( 8 )   1081 - 1085   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Objective We evaluated the clinical effects of a telephone call service for psychological symptoms such as anxiety, depression or apathy in subacute myelo-optico-neuropathy (SMON) patients living alone or with a single caregiver.Methods Up to 16 SMON patients (4 men, 12 women) and 32 control subjects were evaluated by the geriatric depression scale (GDS), apathy scale (AS) and state and trait anxiety inventory (STAI) forms X-I, including the P and A values for depression, apathy and state anxiety including disturbed peace of mind and enhanced anxiety, respectively, before (pre) and three months after (post) the telephone call service.Results The SMON patients, especially women, had significantly worse baseline scores in GDS (depression), AS (apathy) and STAI (state anxiety) than control subjects. The automated telephone call service significantly improved the high baseline STAI scores, including the P and A scores (disturbed peace of mind and enhanced anxiety), of SMON patients but not the GDS or AS scores.Conclusion SMON patients, especially women, living alone or with a single caregiver showed higher baseline depression, apathy and anxiety scores than the control subjects. The present automated telephone call service proved to be a useful care tool for improving the anxiety of SMON patients with high STAI P and A scores.

    DOI: 10.2169/internalmedicine.1554-18

    Web of Science

    researchmap

  • 一般住民健診における不眠症と認知・情動機能障害の特徴

    菱川 望, 福井 裕介, 武本 麻美, 商 敬偉, 佐藤 恒太, 太田 康之, 山下 徹, 阿部 康二

    臨床神経学   58 ( Suppl. )   S299 - S299   2018.12

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • Neuroprotective effects of SMTP-44D in mice stroke model in relation to neurovascular unit and trophic coupling

    Xiaowen Shi, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Eriko Suzuki, Keiji Hasumi, Koji Abe

    JOURNAL OF NEUROSCIENCE RESEARCH   96 ( 12 )   1887 - 1899   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Stachybotrys microspora triprenyl phenol (SMTP)-44D has both anti-oxidative and anti-inflammatory activities, but its efficacy has not been proved in relation to the pathological changes of neurovascular unit (NVU) and neurovascular trophic coupling (NVTC) in ischemic stroke. Here, the present study was designed to assess the efficacies of SMTP-44D, moreover, compared with the standard neuroprotective reagent edaravone in ischemic brains. ICR mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 60 min, SMTP-44D (10 mg/kg) or edaravone (3 mg/kg) was intravenously administrated through subclavian vein just after the reperfusion, and these mice were examined at 1, 3, and 7 d after reperfusion. Compared with the vehicle group, SMTP-44D treatment revealed obvious ameliorations in clinical scores and infarct volume, meanwhile, markedly suppressed the accumulations of 4-HNE, 8-OHdG, nitrotyrosine, RAGE, TNF-alpha, Iba-1, and cleaved caspase-3 after tMCAO. In addition, SMTP-44D significantly prevented the dissociation of NVU and improved the intensity of NAGO/BDNF and the number of BDNF/TrkB and BDNF/NeuN double positive cells. These effects of SMTP-44D in reducing oxidative and inflammatory stresses were similar to or stronger than those of edaravone. The present study demonstrated that SMTP-44D showed strong anti-oxidative, anti-inflammatory, and anti-apoptotic effects, moreover, the drug also significantly improved the NVU damage and NVTC in the ischemic brain.

    DOI: 10.1002/jnr.24326

    Web of Science

    researchmap

  • Cervical compressive myelopathy caused by malfunction of a programmable cerebrospinal fluid shunt valve Reviewed

    Kota Sato, Toru Yamashita, Keichiro Tsunoda, Mami Takemoto, Nozomi Hishikawa, Jinwei Shang, Yasuyuki Ohta, Ken Kuwahara, Takao Yasuhara, Isao Date, Koji Abe

    INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT   14   183 - 185   2018.12

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    The primary treatment for hydrocephalus is ventricular shunt placement, and a programmable valve is widely used for ventriculoperitoneal (VP) shunt surgery to reduce over/under drainage of cerebrospinal fluid (CSF). Here, we report a rare case of a patient who developed successive VP shunt malfunction causing spastic muscle weakness in extremities associated cervical epidural venous distension and compressive myelopathy due to over-drainage of CSF through a defective VP shunt valve a decade after the initial shunt was placed. One should be aware and cognizant of this complication and carefully follow the symptoms and potentially utilize brain MRI with and without contrast to look at over drainage stigmata to avoid the development of neurological complications.

    DOI: 10.1016/j.inat.2018.08.009

    Web of Science

    researchmap

  • Different clinicopathological features between Japanese siblings with facioscapulohumeral muscular dystrophy 2 with a novel nonsense SMCHD1 mutation (Arg552*)

    Yasuyuki Ohta, Koh Tadokoro, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Jingwei Shang, Toru Yamashita, Yasushi Takehisa, Ichizo Nishino, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   58   215 - 217   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Facioscapulohumeral muscular dystrophy (FSHD) 2 is caused by a combination of heterozygous structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHDI) mutation plus DNA hypomethylation on D4Z4. Here we report two Japanese FSHD2 siblings (brother and sister) with a new SMCHD1 nonsense mutation (a heterogeneous c. 1654C > T substitution, leading to a stop codon Arg552*). They showed the typical phenotype of FSHD2 such as asymmetric muscle weakness and atrophy in bilateral facial, scapular and humeral muscles, but different clinicopathological features between them. The brother and asymptomatic mother showed normal D4Z4 methylation plus the same SMCHD1 mutation, but the sister showed the SMCHD1 mutation plus D4Z4 hypomethylation, suggesting an interesting correlation of the new SMCHD1 nonsense mutation and D4Z4 hypomethylation. (C) 2018 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2018.10.021

    Web of Science

    researchmap

  • Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Xianghong Li, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   27 ( 12 )   3521 - 3528   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both thrombolytic and anti-inflammatory effects, but its neuroprotective effects on cerebral ischemia are still unclear. The present study assessed the antioxidative and neurovascular unit (NVU) protective effects of SMTP-7 using transient middle cerebral artery occlusion (tMCAO) mice. Methods: After 60 minutes tMCAO, 0.9% NaC1, tissue-type plasminogen activator (tPA), SMTP-7 or tPA + SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the hemorrhage and expressive changes of antioxidative markers in brains. Results: SMTP-7 treatment showed a similar antithrombotic effect to tPA, but significantly decreased the hemorrhage volumes and the number of 4-HNE, 3-NT and 8-OHdG positive cells, meanwhile, ameliorated the decrease of collagen IV in the ischemic brains. However, tPA + SMTP-7 treatment did not decrease hemorrhage volumes nor showed NVU protective effect. Conclusions: The present study suggested that SMTP-7 provided therapeutic benefits for ischemic stroke through antioxidative and NVU protective effects unlike tPA alone or tPA + SMTP-7.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.018

    Web of Science

    researchmap

  • Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Xianghong Li, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   27 ( 12 )   3521 - 3528   2018.12

     More details

    Publishing type:Research paper (scientific journal)  

    © 2018 Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both thrombolytic and anti-inflammatory effects, but its neuroprotective effects on cerebral ischemia are still unclear. The present study assessed the antioxidative and neurovascular unit (NVU) protective effects of SMTP-7 using transient middle cerebral artery occlusion (tMCAO) mice. Methods: After 60 minutes tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA + SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the hemorrhage and expressive changes of antioxidative markers in brains. Results: SMTP-7 treatment showed a similar antithrombotic effect to tPA, but significantly decreased the hemorrhage volumes and the number of 4-HNE, 3-NT and 8-OHdG positive cells, meanwhile, ameliorated the decrease of collagen IV in the ischemic brains. However, tPA + SMTP-7 treatment did not decrease hemorrhage volumes nor showed NVU protective effect. Conclusions: The present study suggested that SMTP-7 provided therapeutic benefits for ischemic stroke through antioxidative and NVU protective effects unlike tPA alone or tPA + SMTP-7.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.018

    Scopus

    PubMed

    researchmap

  • コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への影響

    太田 康之, 菱川 望, 山下 徹, 佐藤 恒太, 武本 麻美, 阿部 康二

    神経治療学   35 ( 6 )   S238 - S238   2018.11

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • A case of aspergillotic orbital apex syndrome diagnosed by an additional intraorbital biopsy after nasal endoscopy Reviewed

    Namiko Matsumoto, Kota Sato, Koh Tadokoro, Yoshiaki Takahashi, Taijun Yunoki, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Kentaro Fujii, Tomotsugu Ichikawa, Isao Date, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 6 )   188 - 190   2018.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    The prompt and accurate diagnosis of orbital apex syndrome (OAS) is very important because of its fatality. Here we report an old man with aspergillotic OAS diagnosed after two biopsies by nasal endoscopy and craniotomy. Only craniotomy leads to the appropriate diagnosis, suggesting an immediate need of additional biopsy for the accurate diagnosis and saving the patient.

    DOI: 10.1111/ncn3.12226

    Web of Science

    researchmap

  • Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   27 ( 11 )   3084 - 3094   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both potentials of thrombolytic and neuroprotective effects, but its detailed neuroprotective mechanisms in ischemic stroke are still unclear. Here, we assessed the neuroprotective effects of SMTP-7 for anti-inflammatory and antiapoptosis mechanisms after 60 minutes of transient middle cerebral artery occlusion (tMCAO) in mice. Methods: After 60 minutes of tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA+SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the antineuroinflammatory effect of SMTP-7 on the expressive changes of inflammatory markers in ischemic mouse brains. Results: Compared with the vehicle and tPA groups, SMTP-7 treatment significantly improved clinical scores and decreased the infarct volume and the numbers of TNE-alpha, nuclear factor-kappa B (NF-kappa B), nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3), and cleaved caspase-3-positive cells in the brain of mice at 24 hours after tMCAO but not p62-positive cells. However, tPA+SMTP-7 treatment did not show such effects. Conclusions: The present study suggested that SMTP-7 provides a therapeutic benefit for ischemic stroke mice through anti-inflammatory and antiapoptotic effects but not antiautophagic effect.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.039

    Web of Science

    researchmap

  • Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice

    Yong Huang, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

    Journal of Stroke and Cerebrovascular Diseases   27 ( 11 )   3084 - 3094   2018.11

     More details

    Publishing type:Research paper (scientific journal)  

    © 2018 Background: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both potentials of thrombolytic and neuroprotective effects, but its detailed neuroprotective mechanisms in ischemic stroke are still unclear. Here, we assessed the neuroprotective effects of SMTP-7 for anti-inflammatory and antiapoptosis mechanisms after 60 minutes of transient middle cerebral artery occlusion (tMCAO) in mice. Methods: After 60 minutes of tMCAO, 0.9% NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA+SMTP-7 was intravenously administrated through subclavian vein just before the reperfusion, and these mice were examined at 24 hours after reperfusion. We histologically assessed the antineuroinflammatory effect of SMTP-7 on the expressive changes of inflammatory markers in ischemic mouse brains. Results: Compared with the vehicle and tPA groups, SMTP-7 treatment significantly improved clinical scores and decreased the infarct volume and the numbers of TNF-α, nuclear factor-κB (NF-κB), nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3), and cleaved caspase-3-positive cells in the brain of mice at 24 hours after tMCAO but not p62-positive cells. However, tPA+SMTP-7 treatment did not show such effects. Conclusions: The present study suggested that SMTP-7 provides a therapeutic benefit for ischemic stroke mice through anti-inflammatory and antiapoptotic effects but not antiautophagic effect.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.06.039

    Scopus

    PubMed

    researchmap

  • 胃瘻造設後に高浸透圧高血糖症候群をきたした進行性核上性麻痺の一例

    田所 功, 佐藤 恒太, 森原 隆太, 佐々木 諒, 高橋 義秋, 商 敬偉, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   81 - 81   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • マウス脳梗塞モデルにおける新規抗酸化サプリメントTwendeeXの脳保護効果

    中野 由美子, 草木 桃子, 太田 康之, 山下 徹, 犬房 春彦, 森原 隆太, 商 敬偉, 佐藤 恒太, 武本 麻美, 菱川 望, 阿部 康二

    脳循環代謝   30 ( 1 )   140 - 140   2018.10

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • Affective improvement of neurological disease patients and caregivers using an automated telephone call service

    Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Mami Takemoto, Shinji Doutare, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   56   74 - 78   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Neurological disease patients living alone or with a single caregiver need a support system to care for their psychological symptoms. We evaluated the clinical effects of a unique telephone call system that automatically called participants at their desired times once a week for 3 months. In total, 104 neurological disease patients and caregivers were evaluated by the geriatric depression scale, apathy scale and state and trait anxiety inventories (STAI) forms X-I for depression, apathy and state anxiety, respectively. High baseline STAI scores (40 >=) significantly improved in the Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and spinocerebellar degeneration (SCD) + multiple system atrophy (MSA) patients (p = 0.001, p = 0.013 and p = 0.046, respectively) after patients/caregivers used the telephone call service. The baseline (pre) STAI score significantly correlated with the score change (post-pre) in PD, ALS, SCD + MSA, Alzheimer' s disease patients (ADp), and caregivers for ADp (p < 0.0001, p = 0.001, p = 0.011, p = 0.025 and p = 0.020, respectively). The geriatric depression scale and apathy scale did not significantly improve. The present study suggests that there is a positive effect of using an automated telephone call service for anxiety in neurological disease patients and caregivers, especially in ALS, SCD + MSA and PD patients with high STAI scores (40 >=). (C) 2018 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2018.07.006

    Web of Science

    researchmap

  • コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への治療効果

    太田 康之, 菱川 望, 山下 徹, 佐藤 恒太, 武本 麻美, 阿部 康二

    Dementia Japan   32 ( 3 )   473 - 473   2018.9

     More details

    Language:Japanese   Publisher:(一社)日本認知症学会  

    researchmap

  • Rare valiant vertical one-and-a-half syndrome without ipsilateral upward gaze palsy in a patient with thalamomesencephalic stroke

    Kota Sato, Yoshiaki Takahashi, Namiko Matsumoto, Taijun Yunoki, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 5 )   133 - 135   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Bilateral upward and ipsilateral downward gaze palsy due to a unilateral thalamomesencephalic stroke is called vertical one-and-a-half syndrome (VOHS). Here, we report a valiant VOHS case who presented contralateral upward and ipsilateral downward gaze palsy due to a unilateral thalamomesencephalic stroke. The neuronal fiber connections associated with vertical gaze are not completely understood, so the present case provides an important proof to obtain a better understanding of vertical gaze mechanisms.

    DOI: 10.1111/ncn3.12210

    Web of Science

    researchmap

  • Vogt-Koyanagi-Harada case accompanied by polyneuropathy Reviewed

    Keiichiro Tsunoda, Yasuyuki Ohta, Koh Tadokoro, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Ai Kajita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 5 )   138 - 140   2018.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Vogt-Koyanagi-Harada disease (VKHD) is a systemic autoimmune disease that targets melanocyte-rich tissues such as eye, central nervous system, inner ear, and skin. Here, we report a case of VKHD accompanied by polyneuropathy. After VKHD was diagnosed, depending on the involvement of bilateral ocular, auditory, and central nervous systems, he expressed muscle weakness, pain, and numbness in bilateral lower extremities. Nerve conduction studies suggested sensorimotor polyneuropathy, while a skin, muscle, and nerve biopsy suggested vasculitis. Steroid therapy improved his symptoms. The present case might suggest a relationship between VKHD and polyneuropathy.

    DOI: 10.1111/ncn3.12213

    Web of Science

    researchmap

  • Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain

    Jingwei Shang, Hongjing Yan, Yang Jiao, Yasuyuki Ohta, Xia Liu, Xianghong Li, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xiaowen Shi, Yong Huang, Tian Feng, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   27 ( 8 )   2096 - 2105   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Dietary supplement is an attempt to reduce the risk of ischemic stroke in high-risk population. A new mixed vitamin E-Tocovid that mainly contains tocotrienols other than tocopherol, attenuated the progression of white matter lesions by oral in humans. However, the effect of Tocovid on ischemic stroke has not been examined. In the present study, we assessed the therapeutic effects of Tocovid pretreatment on transient middle cerebral artery occlusion (tMCAO) in mice. Materials and Methods: After pretreatment with Tocovid (200 mg/kg/d) or vehicle for 1 month, 60-minute tMCAO was performed, and these mice were examined at 1 day, 3 days, and 7 days after reperfusion. We histologically assessed the effects of Tocovid pretreatment on the expressive changes of oxidative stress markers, cleaved caspase-3, and LC3-II after tMCAO in mice. Results: We observed that Tocovid pretreatment significantly improved the rotarod time, reduced infarct volume, decreased the number of 4-HNE, nitrotyrosine, and 8-OhdG positive cells, inhibited advanced glycation end products biomarkers RAGE, CMA, and CML expressions, and increased Nrf2 and MRP1 levels with GSSG/GSH ratio decrease. Furthermore, Tocovid pretreatment greatly decreased cleaved caspase-3 and LC3-II expreisions after tMCAO. Conclusions: The present study obviously demonstrated that Tocovid pretreatment showed neuroprotective effects against oxidative stress and at least in part by antiapoptotic/autophagic cell death in ischemic mice brain.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.012

    Web of Science

    researchmap

  • Detecting spinal spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography

    Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROSCIENCE RESEARCH   133   58 - 63   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5. The fractional anisotropy (FA) values of ALS-total and ALS-limb patients were significantly reduced compared with normal controls, and SBMA patients. On the other hand, the mean diffusivity (MD) values were not significantly different among normal controls and the three disease groups. The rate of disease progression (Delta FRS-R) of ALS patients was significantly correlated with FA values and central motor conduction time (CMCT). In conclusion, the present study demonstrated a significant reduction of FA values in ALS patients, and the Delta FRS-R of ALS patients showed distinct regressions with FA values and CMCT, suggesting that this DTT analysis could be useful for detecting disease progression of ALS patients. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

    DOI: 10.1016/j.neures.2017.11.005

    Web of Science

    researchmap

  • Detecting spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography Reviewed

    Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    Neuroscience Research   133   58 - 63   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5. The fractional anisotropy (FA) values of ALS-total and ALS-limb patients were significantly reduced compared with normal controls, and SBMA patients. On the other hand, the mean diffusivity (MD) values were not significantly different among normal controls and the three disease groups. The rate of disease progression (ΔFRS-R) of ALS patients was significantly correlated with FA values and central motor conduction time (CMCT). In conclusion, the present study demonstrated a significant reduction of FA values in ALS patients, and the ΔFRS-R of ALS patients showed distinct regressions with FA values and CMCT, suggesting that this DTT analysis could be useful for detecting disease progression of ALS patients.

    DOI: 10.1016/j.neures.2017.11.005

    Scopus

    PubMed

    researchmap

  • Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model

    Yang Jiao, Jingwei Shang, Yasuyuki Ohta, Hongjing Yan, Xia Liu, Xianghong Li, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xiaowen Shi, Yong Huang, Tian Feng, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   27 ( 8 )   2166 - 2174   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Tocovid is a new combination of tocotrienols and tocopherol, both of which are neuroprotective agents for preventing cerebral infarction in mice. However, the effects of tocovid on anti-inflammation in ischemic model remain elusive. In the present study, we assessed the effects of Tocovid pretreatment on anti-inflammatory effects after transient middle cerebral occlusion (tMCAO) in mice. Materials and Methods: We evaluated the therapeutic and anti-inflammatory effects of tocovid pretreatment (200 mg/kg per day, for 1 month) on mice brain under 60 minutes of tMCAO. The expressive changes of inflammatory markers were ob-served after tMCAO in mice. Results: Tocovid pretreatment greatly improved the mice neurobehaviors, reduced infarct volumes and decreased expressions of in-flammatory markers such as tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1) and ionized calcium binding adapter molecule-1 (Iba-1), and improved the damage of neurovascular units including matrix metallopeptidase 9, IgG and collagen IV after tMCAO. Conclusions: Our present findings demon-strated that oral tocovid pretreatment showed obviously neuroprotective and at least in part by anti-inflammatory effects in ischemic mice brain.

    DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.014

    Web of Science

    researchmap

  • A unique telephone support system for dementia patients and their caregivers managed in Japan (Okayama Dementia Call Center, ODCC) Reviewed

    Yumiko Nakano, Nozomi Hishikawa, Keiko Sakamoto, Yoko Myoraku, Yoshinori Ozaki, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 4 )   100 - 103   2018.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Background: Despite a rapidly increasing prevalence of dementia, social support systems for dementia patients and their caregivers are insufficient.Aim: To investigate a telephone support system for dementia patients and their caregivers managed by a local public association, the Okayama Dementia Call Center (ODCC).Methods: A total of 1485 phone calls were retrospectively surveyed over 4 years (from June 2011 to May 2014) and were divided into four annual periods.Results: The average consulting time of each of the 1485 phone calls was 20.2 14.7 min. The chief complaint was distress related to dementia symptoms (56.2%), mainly from the children (66.7%) and spouses (17.5%) of dementia patients. With respect to management of ODCC for these clients, the proportion of providing advice has decreased (66.1 to 47.7%) as that of listening time increased (22.7 to 46.1%).Conclusion: The present unique telephone call system (ODCC) may supplement an insufficient social support, and may play an important role in the community care system, enabling people with dementia to live comfortably in their local community.

    DOI: 10.1111/ncn3.12200

    Web of Science

    researchmap

  • Fulminant Guillain-Barre syndrome with Takotsubo cardiomyopathy: Report of an autopsied case Reviewed

    Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Nozomi Hishikawa, Kota Sato, Keiichiro Tsunoda, Jingwei Shang, Kentaro Deguchi, Takehiro Tanaka, Hirotake Nishimura, Masumi Furutani, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 4 )   117 - 119   2018.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report a case of a 77-year-old Japanese man with a fever of up to 39.0 degrees C, which subsided after 5 days. The patient showed fulminant Guillain-Barre syndrome (GBS), severe autonomic dysfunction with a labile blood pressure, an unstable heart rate from onset to death, and Takotsubo cardiomyopathy. Although Takotsubo cardiomyopathy was ameliorated by Day 14 (from admission in the hospital) with a normalized electrocardiogram, his blood pressure became markedly more variable and he died on Day 26. In the present report, we describe an autopsied case of GBS with Takotsubo cardiomyopathy.

    DOI: 10.1111/ncn3.12197

    Web of Science

    researchmap

  • Clinical predictors of Alzheimer's disease progression

    Nozomi Hishikawa, Yusuke Fukui, Mami Takemoto, Kota Sato, Jingwei Shang, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    Geriatrics and Gerontology International   18 ( 6 )   929 - 936   2018.6

     More details

    Publishing type:Research paper (scientific journal)  

    © 2018 Japan Geriatrics Society Aim: Rates of disease progression differ among patients with Alzheimer's disease (AD), but prognostic predictions remain a challenge. We carried out a clinic-based retrospective study to investigate the clinical factors for AD progression. Methods: The 748 AD patients, who attended our hospital for >1 year and were given the Mini-Mental State Examination (MMSE) at least three times, were divided into three groups according to the annual change rate of MMSE score (G): Aggravater group (G < −2), Stabler group (−2 ≤ G ≤ 2) and Improver group (2 < G). We compared the three groups on cognitive, affective and activities of daily living functions, response to medication, clinical fluctuations, serum levels of metabolic factors, and neuroimaging data. Results: We found no significant differences in age, sex, educational attainment or body mass index across the groups. The Aggravater group showed better baseline MMSE (P < 0.01) and Abe's behavioral and psychological symptoms of dementia (P < 0.01) scores than the Improver group, but its MMSE improvement after drug treatment was the worst among the three groups (P < 0.01 vs Stabler/Improver). Fluctuations in MMSE (P < 0.01), apathy scale (P < 0.05) and activities of daily living (P < 0.01) scores were smaller in the Improver group than in the Aggravater or Stabler groups. Serum docosahexaenoic acid levels tended to be lower (trend P < 0.05) and voxel-based specific regional analysis system for Alzheimer's disease Z-scores tended to be higher (trend P < 0.05) in the Improver group than in the Stabler or Aggravater groups. Conclusions: Initial responses to medication, fluctuations in cognitive, affective and activities of daily living functions, serum docosahexaenoic acid levels, and medial temporal atrophy are clinical factors related to AD prognosis. Geriatr Gerontol Int 2018; 18: 929–936.

    DOI: 10.1111/ggi.13286

    Scopus

    PubMed

    researchmap

  • Clinical predictors of Alzheimer's disease progression

    Nozomi Hishikawa, Yusuke Fukui, Mami Takemoto, Kota Sato, Jingwei Shang, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    GERIATRICS & GERONTOLOGY INTERNATIONAL   18 ( 6 )   929 - 936   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    AimRates of disease progression differ among patients with Alzheimer's disease (AD), but prognostic predictions remain a challenge. We carried out a clinic-based retrospective study to investigate the clinical factors for AD progression.MethodsThe 748AD patients, who attended our hospital for >1year and were given the Mini-Mental State Examination (MMSE) at least three times, were divided into three groups according to the annual change rate of MMSE score (G): Aggravater group (G<-2), Stabler group (-2G2) and Improver group (2<G). We compared the three groups on cognitive, affective and activities of daily living functions, response to medication, clinical fluctuations, serum levels of metabolic factors, and neuroimaging data.ResultsWe found no significant differences in age, sex, educational attainment or body mass index across the groups. The Aggravater group showed better baseline MMSE (P<0.01) and Abe's behavioral and psychological symptoms of dementia (P<0.01) scores than the Improver group, but its MMSE improvement after drug treatment was the worst among the three groups (P<0.01 vs Stabler/Improver). Fluctuations in MMSE (P<0.01), apathy scale (P<0.05) and activities of daily living (P<0.01) scores were smaller in the Improver group than in the Aggravater or Stabler groups. Serum docosahexaenoic acid levels tended to be lower (trend P<0.05) and voxel-based specific regional analysis system for Alzheimer's disease Z-scores tended to be higher (trend P<0.05) in the Improver group than in the Stabler or Aggravater groups.ConclusionsInitial responses to medication, fluctuations in cognitive, affective and activities of daily living functions, serum docosahexaenoic acid levels, and medial temporal atrophy are clinical factors related to AD prognosis. Geriatr Gerontol Int 2018; 18: 929-936.

    DOI: 10.1111/ggi.13286

    Web of Science

    researchmap

  • A case of bilateral internal carotid artery dissection in young adult with cranial nerve IX and X palsies Reviewed

    Ryo Sasaki, Toru Yamashita, Yoshiaki Takahashi, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 3 )   80 - 82   2018.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Internal carotid artery (ICA) dissection is a major cause of cerebral infarction in young adult and usually presents cervical pain and headache, but rarely presents cranial nerve palsy. Here, we report a case of rare bilateral ICA dissections in young adult with cranial nerve IX and X palsies as initial symptom. He presented dysarthria and nasal voice at an early stage, followed by a small brain infarction. The cranial nerve palsy was improved in parallel with the improvement of ICA stenosis and dilatation. It is important to know that cranial nerve palsy can be one of the symptoms of ICA dissection for appropriate treatment.

    DOI: 10.1111/ncn3.12187

    Web of Science

    researchmap

  • Case of acromegalic myopathy and arthropathy long after trans-sphenoidal surgery Reviewed

    Ryo Sasaki, Toru Yamashita, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 3 )   77 - 79   2018.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Acromegaly patients usually show impaired vision, the enlargement of hands and feet, heart failure, and diabetes and rarely show myopathy (weakness and muscle pain) and arthropathy (joint pain). Here, we report an acromegaly patient who showed progressive myopathy and arthropathy long after a Hardy operation. The symptoms of myopathy and arthropathy occurred under normal GH and high IGF-1 levels, but these symptoms improved when the IGF-1 level was normalized by a treatment of octreotide with an increased dose of 30-40 mg. Thus, strict and immediate control of IGH-1 may be pivotally important to prevent and treat acromegalic myopathy and arthropathy.

    DOI: 10.1111/ncn3.12191

    Web of Science

    researchmap

  • Case of congenital fibrosis of the extraocular muscles type 1 with progressive cerebellar ataxia

    Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Emi Nomura, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 2 )   48 - 50   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    A 70-year-old women presented classical CEFOM1 phenotypes such as bilateral ptosis and external ophthalmoplegia, but also progressive cerebellar ataxia, carrying a previously reported heterozygous missense mutation of KIF21A p.Arg941Gln. The present case is the first report of CFEOM1 showing cerebellar atrophy with hypoperfusion, mainly of the vermis, indicating that cerebellar function should be carefully evaluated in CFFOM1 patients.

    DOI: 10.1111/ncn3.12178

    Web of Science

    researchmap

  • Emergency ventricular drainage plus systemic antibiotics saved an elderly patient with intraventricular rupture as a result of a pituitary abscess

    Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   6 ( 1 )   13 - 15   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    A pituitary abscess is a rare intracranial infection, and direct transsphenoidal surgery is common for the therapy. Intracranial rupture of the pituitary abscess is usually fatal. Here, we report a 76-year-old woman with a pituitary abscess who showed headaches, left eyelid ptosis, periorbital swelling and external eye movement disturbances in the left eye. Although her symptoms initially improved after therapy with systemic antibiotics, the pituitary abscess suddenly developed an intraventricular rupture on admission day 27. However, emergency ventricular drainage in combination with different antibiotics gradually improved her condition. The present case suggests that the combination of emergency ventricular drainage and systemic antibiotic administration could serve as an alternative choice to manage pituitary abscesses of ventricular ruptures, especially in elderly patients.

    DOI: 10.1111/ncn3.12167

    Web of Science

    researchmap

  • A Japanese Encephalitis Patient Presenting with Parkinsonism with Corresponding Laterality of Magnetic Resonance and Dopamine Transporter Imaging Findings

    Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Takahiro Maeki, Ryo Sasaki, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Chang Kweng Lim, Shigeru Tajima, Koji Abe

    INTERNAL MEDICINE   57 ( 15 )   2243 - 2246   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using I-123-labeled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (I-123-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

    DOI: 10.2169/internalmedicine.0337-17

    Web of Science

    researchmap

  • Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy

    Ryo Sasaki, Yasuyuki Ohta, Yuto Yamada, Koh Tadokoro, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takao Yasuhara, Isao Date, Shuntaro Ikegawa, Nobuharu Fujii, Koji Abe

    INTERNAL MEDICINE   57 ( 23 )   3463 - 3465   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Neurolymphomatosis is a rare form of extranodal malignant lymphoma defined as the infiltration of malignant lymphocytes into the central or peripheral nerve. We herein report a case of neurolymphomatosis in the cauda equina diagnosed by an open surgical biopsy. He presented with muscle weakness, atrophy, numbness and hypoesthesia in the bilateral lower extremities with the accumulation of (18)fluoro-2-deoxyglucose (FDG) in the bilateral cauda equina. Cerebrospinal fluid cytology (three times) and flow cytometry (two times) and biopsies of the left rural nerve, bone marrow, paranasal sinus and left testis were all negative for malignancy, so finally we performed a surgical open biopsy of the cauda equina by laminectomy and diagnosed him with diffuse large B-cell lymphoma in the cauda equina. He was successfully treated with the disappearance of the FDG accumulation for a long time. The present case suggested that an early open biopsy of the cauda equina may be considered for cases of suspected neurolymphomatosis in the cauda equina for a good outcome.

    DOI: 10.2169/internalmedicine.1049-18

    Web of Science

    researchmap

  • A unique case of hemi-tongue pseudohypertrophy, necrotizing myopathy, and erythema nodosum

    Kota Sato, Yoshiaki Takahashi, Toni Yamashita, Mami Takemoto, Nozomi Hishikawa, Shang Jinwei, Yasuyuki Ohta, Koji Abe

    NEUROLOGY INTERNATIONAL   10 ( 4 )   95 - 96   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PAGEPRESS PUBL  

    A 46-year-old woman developed slowly progressive tongue weakness with a pseudohypertrophic change on the right side of her tongue. She subsequently developed weakness in her proximal lower extremities, skin erythema and a sustained increase of muscle enzymes at 11 M after the onset. A biopsy of the quadriceps muscle showed necrotizing myopathy and a skin biopsy showed erythema nodosum. The present case showed characteristic clinical manifestations that may represent a rare variant of sarcoidosis.

    DOI: 10.4081/ni.2018.7852

    Web of Science

    researchmap

  • A unique case with oral dyskinesia, chorea, ataxia, and mild cognitive impairment with caudate atrophy and characteristic brain calcifications

    Nozomi Hishikawa, Yusuke Fukui, Kota Sato, Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Koji Abe

    Internal Medicine   57 ( 16 )   2399 - 2402   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2018 The Japanese Society of Internal Medicine. The authors report a man who developed oral dyskinesia at 46 years of age, followed by slowly progressive choreic movement and mild cognitive impairment over 20 years. He showed caudate atrophy and four types of intracranial calcification in the hippocampus (dot-like), cerebellar white matter (vague-mass), occipi-tal cortices (laminar), and cerebral white matter (linear). Linear-calcification in the corona radiata seems to be deposition along small veins, which may be related to the white matter changes and to the decreased regional cerebral blood flow in the frontal and parietal lobes. The present case shows a slowly progressive disease with caudate atrophy and characteristic brain calcifications.

    DOI: 10.2169/internalmedicine.9454-17

    Scopus

    PubMed

    researchmap

  • A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications

    Nozomi Flishikawa, Yusuke Fukui, Kota Sato, Mami Takemoto, Tom Yamashita, Yasuyuki Ohta, Koji Abe

    INTERNAL MEDICINE   57 ( 16 )   2399 - 2402   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    The authors report a man who developed oral dyskinesia at 46 years of age, followed by slowly progressive choreic movement and mild cognitive impairment over 20 years. He showed caudate atrophy and four types of intracranial calcification in the hippocampus (dot-like), cerebellar white matter (vague-mass), occipital cortices (laminar), and cerebral white matter (linear). Linear-calcification in the corona radiata seems to be deposition along small veins, which may be related to the white matter changes and to the decreased regional cerebral blood flow in the frontal and parietal lobes. The present case shows a slowly progressive disease with caudate atrophy and characteristic brain calcifications.

    DOI: 10.2169/internalmedicine.9454-17

    Web of Science

    researchmap

  • PDDとDLBの認知機能、情動機能、脳血流分布の比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    Anti-aging Science   9 ( 2 )   109 - 109   2017.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • メタボリック症候群を伴うアルツハイマー病の特徴

    菱川 望, 福井 裕介, 武本 麻美, 佐藤 恒太, 太田 康之, 山下 徹, 阿部 康二

    Anti-aging Science   9 ( 2 )   111 - 111   2017.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • 大脳白質病変を伴うアルツハイマー病患者における抗認知症薬の臨床的効果

    福井 裕介, 菱川 望, 佐藤 恒太, 中野 由美子, 森原 隆太, 武本 麻美, 商 敬偉, 太田 康之, 山下 徹, 阿部 康二

    Anti-aging Science   9 ( 2 )   110 - 110   2017.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease Reviewed

    Keiichiro Tsunoda, Toru Yamashita, Hitoshi Shimada, Emi Nomura, Yoshiaki Takahashi, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Makoto Higuchi, Tetsuya Suhara, Yasumasa Kokubo, Shigeki Kuzuhara, Koji Abe

    JOURNAL OF CLINICAL NEUROSCIENCE   46   64 - 67   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is an endemic disease observed in the Kii peninsula, Guam, and Papua. We report a case of a 76-year old man with ALS/PDC of the Kii peninsula of Japan (Kii ALS/PDC). The patient was born and grew up in the Kii peninsula. He moved out at age three, and developed symptoms 73 years later. He showed pyramidal sign, parkinsonian symptoms, and mildly impaired cognitive function. I-131-metaiodobenzylguanidine myocardial scintigraphy showed decreased cardiac sympathetic nerve function, and dopamine transporter single photon emission computed tomography imaging showed decreased I-123-N-omega-fluoropropy1-2 beta-carbomethoxy3 beta-(4-iodo phenyl) nortropane accumulation. Cerebral blood flow showed hypoperfusion. Positron emission tomography showed widespread tau deposition in his brain. This is a migration case of Kii ALS/PDC with the shortest stay in the endemic area and the longest delay to develop the disease, indicating a genetic factor for the disease development in a considerable degree. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jocn.2017.08.057

    Web of Science

    researchmap

  • Japanese sibling cases of multiple sclerosis presenting with different clinical phenotypes

    Kota Sato, Yasuyuki Ohta, Toru Yamashita, Keiichiro Tsunoda, Kentaro Deguchi, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   186 - 188   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Unlike in Western countries, only a few familial multiple sclerosis cases have been reported from Asian countries. Herein, we report on the characteristics of siblings with multiple sclerosis. Their parents were consanguineous, and the siblings showed different first symptoms of gait disturbance or double vision, with a clinical phenotype of primary progressive multiple sclerosis or relapse-remitting multiple sclerosis. Their human leukocyte antigen showed unique subtypes of DPB1 (0501/0901 or 0901/0901) and DRB1 (0406/1502 or 1502/1502).

    DOI: 10.1111/ncn3.12145

    Web of Science

    researchmap

  • Serious hyponatremia induced by a combination of angiotensin II receptor blocker and thiazide caused deterioration of cognitive functions and psychological symptoms in an elderly Alzheimer's disease patient

    Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   192 - 194   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    As the number of elderly people increases, Alzheimer's disease and hypertension have become more common. This is an important case report that shows severe hyponatremia induced by a combination of angiotensin II receptor blocker and thiazide, causing the deterioration of cognitive functions in an elderly patient. In rapidly aging societies around the world, more attention should be paid to hyponatremia under combination therapy of angiotensin II receptor blocker plus thiazide to assist elderly patients.

    DOI: 10.1111/ncn3.12161

    Web of Science

    researchmap

  • Type 2 Alexander disease with a novel glial fibrillary acidic protein gene mutation and its unique clinical features

    Yuko Kawahara, Toru Yamashita, Yasuyuki Ohta, Kota Sato, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Jingwei Shang, Tomokatsu Yoshida, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 6 )   183 - 185   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    We report mother-daughter cases of type 2 Alexander disease with a novel glial fibrillary acidic protein gene mutation. The mother (proband) began to show slowly progressive gait disturbance. However, after an incidental medical checkup, it took just 9 months for the diagnosis. Different from the previous reports, she showed a unique phenotype in points of scoliosis without palatal myoclonus, decreased regional cerebral blood flow in the frontal lobe and mild cognitive impairment. Her second daughter showed mild intellectual disability. Genetic analysis of the mother and the second daughter showed the same novel glial fibrillary acidic protein gene mutation (c.371_372insAGA).

    DOI: 10.1111/ncn3.12146

    Web of Science

    researchmap

  • Therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with Alzheimer's disease. Reviewed

    Yasuyuki Ohta, Mohamed Darwish, Nozomi Hishikawa, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Abe

    Geriatrics & gerontology international   17 ( 11 )   1843 - 1848   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    AIM: To evaluate the therapeutic effects of switching from one acetylcholinesterase inhibitor (ChEI), donepezil, galantamine or rivastigmine, to another in Alzheimer's disease patients. METHODS: We retrospectively enrolled 171 Alzheimer's disease patients, whose ChEI medication was changed. The patients were evaluated on three major aspects of dementia - cognitive, affective and activities of daily living (ADL) measures - at 6 months (M) before the drug switch, at the time of drug switch (baseline), and at 3 M and 6 M after the drug switch. RESULTS: The doses of the three ChEI were significantly lower at 6 M after the switch compared with the pre-switch doses. Improvements in apathy were found at 3 M when switching from donepezil to galantamine, but not to rivastigmine, but this switch had adverse effects on ADL. Improvements in cognitive scores at 3 M were also found when switching from galantamine to rivastigmine, but not to donepezil. However, both of these changes improved Abe's Behavioral and Psychological Symptoms of Dementia scores (ABS), except ADL. Switching from rivastigmine to donepezil worsened ABS at 6 M, but preserved cognitive and ADL scores. CONCLUSIONS: The present study suggests that despite a relatively lower dose of ChEI after the switch, switching from donepezil or rivastigmine preserved cognitive functions for at least 6 M. Switching from galantamine to rivastigmine improved Mini-Mental State Examination and ABS at 3 M, but did not improve ADL scores. Geriatr Gerontol Int 2017; 17: 1843-1848.

    DOI: 10.1111/ggi.12971

    PubMed

    researchmap

  • 緊急脳室ドレナージと全身抗生剤で救命しえた下垂体部膿瘍から脳室穿破を来した一例

    高橋 義秋, 山下 徹, 森原 隆太, 中野 由美子, 商 敬偉, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    日本頭痛学会誌   44 ( 2 )   386 - 386   2017.11

     More details

    Language:Japanese   Publisher:(一社)日本頭痛学会  

    researchmap

  • 緊急脳室ドレナージと全身抗生剤投与にて救命しえた下垂体部膿瘍から脳室穿破に伸展した一例

    高橋 義秋, 山下 徹, 佐々木 諒, 田所 功, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    臨床神経学   57 ( 10 )   651 - 651   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • Behavioral and affective features of amyotrophic lateral sclerosis patients Reviewed

    Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toni Yamashita, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   381   119 - 125   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale - revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments. The motor functions of ALS patients were evaluated by ALS functional rating scale - revised (ALSFRS-R) and modified Norris scale.ALS-FTD-Q scores showed intermediate behavioral disturbances of ALS patients between ALS-FTD and FTD patients and control subjects, but FAB, MoCA, and anosognosia scales did not. Both FAB and MoCA scores were significantly correlated with MMSE and HDS-R in ALS patients, but ALS-FTD-Q was not. ALS-FTD-Q score was significantly correlated with ALSFRS-R, apathy, BPSD, and ADL scores in ALS patients.Thus, in ALS patients, both FAB and MoCA tests were useful to assess frontal cognitive impairments, while ALS-FTD-Q was useful to detect mild behavioral and affective disturbances.

    DOI: 10.1016/j.jns.2017.08.024

    Web of Science

    researchmap

  • 新しいSCA/ALS crossroad mutation AsidanのDWEP現象

    太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 角田 慶一郎, 武本 麻美, 菱川 望, 阿部 康二

    日本難病医療ネットワーク学会機関誌   5 ( 1 )   59 - 59   2017.9

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • Non-ketotic hyperosmolar coma after percutaneous endoscopic gastrostomy in an advanced stage of progressive supranuclear palsy

    Koh Tadokoro, Kota Sato, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   162 - 164   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Patients with progressive supranuclear palsy often suffer from dysphagia, and percutaneous endoscopic gastrostomy is a treatment option for the advanced stage of this disease. The present percutaneous endoscopic gastrostomy patient had slightly impaired glucose tolerance, but the condition became considerably worse with normal nutrients due to limited activity and an infection after percutaneous endoscopic gastrostomy, resulting in a non-ketotic hyperosmolar coma. After receiving supplementary fluid, intravenous insulin, antibiotics and endotracheal intubation, the patient recovered from the non-ketotic hyperosmolar coma state. Percutaneous endoscopic gastrostomy placement at an advanced stage of a neurodegenerative disorder, such as progressive supranuclear palsy, should have a careful follow-up, especially when glucose tolerance worsens.

    DOI: 10.1111/ncn3.12139

    Web of Science

    researchmap

  • Occult chronic progressive cervical and thoracic myelopathy without evident magnetic resonance imaging lesion

    Emi Nomura, Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Hiroki Ueno, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   155 - 158   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Progressive myelopathy is caused by infectious, inflammatory, autoimmune, paraneoplastic, demyelinating, vascular, hereditary, degenerative, metabolic and toxic properties. Here, we report a case of a 53-year-old woman who showed a progressive cervical and thoracic myelopathy with muscle weakness in all limbs, and hypoesthesia in all limbs and trunk below the Th8 level without any evident magnetic resonance imaging lesions. She displayed rheumatoid factor, anti-double stranded DNA antibody and hepatitis B surface antigen, as well as an elevated cerebrospinal fluid protein level. The paraneoplastic antibodies that we examined were negative. Our treatments (plasma exchange, steroid pulse therapy and immunoglobulin therapy) were slightly effective, but the symptoms did not improve completely. The present case suggests that the presence of a cervical and thoracic lesion without evident magnetic resonance imaging abnormalities required a careful follow up to discover occult lesions.

    DOI: 10.1111/ncn3.12136

    Web of Science

    researchmap

  • Case of myasthenia gravis and Lambert-Eaton myasthenic syndrome overlap syndrome accompanied by autoimmune encephalitis and cerebellar ataxia with multiple neuronal antibodies

    Yumiko Nakano, Emi Nomura, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   152 - 154   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    A 72-year-old woman developed a subacute series of encephalitis, cerebellar ataxia, and combined symptoms of both myasthenia gravis and Lambert-Eaton myasthenic syndrome. Seven different neuronal antibodies were detected for Hu, glutamic acid decarboxylase, acetylcholine receptor, P/Q-type voltage-gated calcium-channels, Zic4, Titin and SOX1 in her serum with intrathecal synthesis of glutamic acid decarboxylase antibodies. Although she showed classical manifestations with onconeural antibodies, she was diagnosed with not paraneoplastic but autoimmune neurological syndrome because of no underlying tumor and good response to immunotherapies. The present case is very unique and rare for complex neurological disorders including myasthenia gravis and Lambert-Eaton myasthenic syndrome overlap syndrome with multiple neuronal antibodies.

    DOI: 10.1111/ncn3.12134

    Web of Science

    researchmap

  • Dissociated recovery between dementia and parkinsonism by transvenous embolization of recurrent dural arteriovenous fistula

    Yumiko Nakano, Emi Nomura, Masafumi Hiramatsu, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Kenji Sugiu, Isao Date, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 5 )   159 - 161   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Dementia and parkinsonism are rarely observed in dural arteriovenous fistula. Here, we report a case of a 63-year-old man with recurrent dural arteriovenous fistula, who developed progressive dementia and parkinsonism as a result of a dural arteriovenous fistula at the torcular herophili. A sinus thrombosis induced the abnormal cortical venous reflux from the isolated straight sinus, resulting in the deep venous congestion of the thalamus and basal ganglia, which led to dementia and parkinsonism. However, the third endovascular embolization ameliorated memory disturbance and apathy with a slight improvement of parkinsonism. Although recoveries from dural arteriovenous fistula-associated neurological deficits are variable depending on the severity, duration and, furthermore, selective vulnerability of the responsible ischemic lesions, early treatment should be essential for better recovery.

    DOI: 10.1111/ncn3.12138

    Web of Science

    researchmap

  • 認知症の早期診断に有用な新しい簡易BPSDスコア(阿部式BPSDスコア=ABS)

    阿部 康二, 菱川 望, 森原 隆太, 中野 由美子, 佐藤 恒太, 武本 麻美, 商 敬偉, 山下 徹

    日本早期認知症学会誌   10 ( 3 )   61 - 61   2017.8

     More details

    Language:Japanese   Publisher:日本早期認知症学会  

    researchmap

  • Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model Reviewed

    Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Xia Liu, Jingwei Shang, Feng Tian, Yusuke Fukui, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   26 ( 6 )   1191 - 1196   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Background: Oxidative stress and inflammation are important aggravating factors in acute ischemic stroke. Methods: In the present study, the neuroprotective effects of a novel antioxidant mixture Twendee X containing multiple antioxidative ingredients, such as coenzyme Q10, ascorbic acid, and cystine, were evaluated. After the pretreatment of a vehicle or Twendee X (20 mg/kg/d) for 14 days, mice were subjected to transient middle cerebral artery occlusion for 60 minutes and further treated with vehicle or Twendee X for 1 or 5 days. Results: Twendee X administration reduced the infarct size, and reduced oxidative stress markers such as 8-hydroxy-2'-deoxyguanosine,4-hydroxy-2-nonenal, and N-epsilon-(carboxymethyl) lysine (one of advanced glycation end products), as well as inflammatory markers such as ionized calcium binding adapter molecule-1, tumor necrosis factor-alpha, and monocyte chemotactic protein-1. Conclusions: In the present study, the neuroprotective effects of Twendee X were shown on transient middle cerebral artery occlusion mice via antioxidative and anti-inflammatory pathways, providing a potential of Twendee X as one preventive and therapeutic treatment. (C) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jstrokecerebrovasdis.2017.01.003

    Web of Science

    researchmap

  • Different Characteristics of Anterior and Posterior Branch Atheromatous Diseases with or without Early Neurologic Deterioration Reviewed

    Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Yasuhiro Manabe, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   26 ( 6 )   1314 - 1320   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: Among several types of ischemic stroke (IS), branch atheromatous disease (BAD) is known to be the leading cause of disability. Methods: A total of 1919 patients with acute IS were retrospectively analyzed, and BAD patients were classified into anterior or posterior BAD, depending on the responsible vascular territories. These patients were further subcategorized with or without early neurologic deterioration (END or no-END). Results: Of all IS patients, 14.3% had BAD, and 202 patients (73.7%) were further classified as anterior BAD and 72 patients (26.3%) as posterior BAD. The prevalence of diabetes mellitus and END was significantly higher in posterior than in anterior BAD (44.4% vs 26.4%, P <.01; 18.1% vs 5.4%, P <.01, respectively). Posterior BAD showed a higher proportion of female patients and an older age (69.2% vs 39.0%, P <.05; 79.1 +/- 7.7 vs 70.5 +/- 10.7, P <.01, respectively) in END than in no-END. The modified Rankin Scale was worse in posterior BAD at 90 days (2.5 +/- 1.6, P <.01) than in anterior BAD (1.6 +/- 1.4). Conclusions: Our present study shows that posterior BAD is a worse clinical outcome than anterior BAD, with more vascular risk factors. Older female patients with posterior BAD showed a higher risk of END, leading to a worse clinical outcome.

    DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.001

    Web of Science

    researchmap

  • Factors related to continuous and discontinuous attendance at memory clinics Reviewed

    N. Hishikawa *,Y. Fukui ,Y. Nakano ,R. Morihara ,M. Takemoto *,K. Sato *,T. Yamashita *,Y. Ohta *,K. Abe *

    European Journal of Neurology   24 ( 5 )   673 - 679   2017.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ene.13268

    researchmap

  • Familial amyotrophic lateral sclerosis of the G37V-superoxide dismutase 1 mutation with a slow disease progression

    Koh Tadokoro, Yasuyuki Ohta, Yoshiaki Takahashi, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    NEUROLOGY AND CLINICAL NEUROSCIENCE   5 ( 3 )   96 - 98   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    The majority of amyotrophic lateral sclerosis patients have the sporadic form, but 5-10% of those have familial amyotrophic lateral sclerosis. A total of 15-20% of familial amyotrophic lateral sclerosis patients have genetic mutations in the superoxide dismutase 1 gene. In 2012, Kobayashi et al. reported the first case of a familial amyotrophic lateral sclerosis patient carrying a G37V superoxide dismutase 1 mutation, who showed rapid progression and died within 1.2 years of onset from respiratory failure. In contrast, here we report the second case of familial amyotrophic lateral sclerosis carrying the G37V superoxide dismutase 1 mutation, showing a very slow progression, and his father and aunt also had longer disease durations from 4 to 6 years. Further clinical and biological studies will clarify the detailed pathological role of the G37V superoxide dismutase 1 mutation for amyotrophic lateral sclerosis.

    DOI: 10.1111/ncn3.12123

    Web of Science

    researchmap

  • Ataxic form of autosomal recessive PEX10-related peroxisome biogenesis disorders with a novel compound heterozygous gene mutation and characteristic clinical phenotype Reviewed

    Toru Yamashita, Jun Mitsui, Nobuyuki Shimozawa, Shigeo Takashima, Hiroshi Umemura, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Takashi Matsukawa, Hiroyuki Ishiura, Jun Yoshimura, Koichiro Doi, Shinichi Morishita, Shoji Tsuji, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   375   424 - 429   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Peroxisome biogenesis factor 10 (PEX10) is involved in the import of peroxisomal matrix proteins, and the mutation of this gene causes 3 subtypes of peroxisome biogenesis disorders, namely Zellweger syndrome (severe), neonatal adrenoleukodystrophy (moderate) and an ataxic form (mild). Here, we report 3 siblings of the ataxic form with cerebellar ataxia, mild mental retardation, and 3 additional characteristic features: mydriasis, hyperreflexia and involuntary head movement. All 3 siblings are compound heterozygous for a previously reported mutation, c.2T>C (p.M1T), and a novel mutation, c920G>A, causing a missense change (p.C307Y) located in the RING finger domain of PEX10. The present cases suggest that these PEX10 mutations involve not only cerebellar but also more multiple nervous systems including pupillary autonomic, pyramidal and extrapyramidal systems. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jns.2017.02.058

    Web of Science

    researchmap

  • Potential multisystem degeneration in Asidan patients Reviewed

    Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Kota Sato, Kosuke Matsuzono, Keiichiro Tsunoda, Noriko Hatanaka, Mami Takemoto, Toshihiko Takemi, Kazuhiro Takamatsu, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   373   216 - 222   2017.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Objective: To evaluate a potential multisystem involvement of neurodegeneration in Asidan, in addition to cerebellar ataxia and signs of motor neuron disease.Methods: We compared the new Asidan patients and those identified in previous studies with Parkinson's disease (PD, n = 21), and progressive supranuclear palsy (PSP, n = 13) patients using I-123-2 beta-Carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (I-123-FP-CIT) dopamine transporter single photon emission computed tomography (DAT-SPECT) and I-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy (Asidan, DAT: n = 10; MIBG: n = 15).Results: Both the PD and PSP groups served as positive controls for DAT decline. The PD and PSP groups served as a positive and negative control, respectively, of MIBG decline in the early phase H/M ratio. Of the Asidan patients, 60.0% showed DAT decline without evident parkinsonian features and 6.7% showed impaired MIBG in only the delayed phase H/M ratio. Combined with a normal range of the early phase H/M ratio, this phenotype was newly named Declined DAT Without Evident Parkinsonism (DWEP).Interpretation: The results of present study including DWEP suggest a wider spectrum of neurodegeneration for extrapyramidal and autonomic systems in Asidan patients than expected, involving cerebellar, motor system and cognitive functioning. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jns.2017.01.003

    Web of Science

    researchmap

  • Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) with Limbic Encephalitis Reviewed

    Yasuyuki Ohta, Emi Nomura, Keiichiro Tsunoda, Toru Yamashita, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    INTERNAL MEDICINE   56 ( 18 )   2513 - 2518   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOC INTERNAL MEDICINE  

    Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids ( CLIPPERS) is an inflammatory central nervous system disorder that mainly involves in the brainstem, basal ganglia and cerebellum. We herein report the case of a patient with CLIPPERS, which was diagnosed based on the clinical and radiological features. After initially responded to steroid treatment, the patient developed limbic encephalitis. The patient presented with memory disturbance, a delirious state and emotional incontinence. A cerebrospinal fluid study revealed interleukin-6 elevation and enhanced bilateral hippocampal lesions were observed on MRI. The patient was successfully treated with methylprednisolone pulse therapy. This is the first case of CLIPPERS with limbic encephalitis involving the bilateral hippocampus.

    DOI: 10.2169/internalmedicine.8533-16

    Web of Science

    researchmap

  • Emergency caesarean section saved both an anti-musk antibody-positive myasthenia gravis mother with pregnancy-induced hypertension and her premature baby

    Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Kei Hayata, Hisashi Masuyama, Tomoka Okamura, Yosuke Washio, Koji Abe

    Internal Medicine   56 ( 24 )   3361 - 3364   2017

     More details

    Publishing type:Research paper (scientific journal)  

    © 2017 The Japanese Society of Internal Medicine. We herein report the case of a 46-year-old pregnant woman with anti-muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) who showed pregnancy-induced hypertension and developed respiratory failure at 30 weeks and 5 days of pregnancy, and who underwent an emergency caesarean section (CS). Her MG symptoms gradually improved in the subsequent weeks. The premature baby with positive MuSK antibodies was successfully delivered, but the male baby required temporary artificial ventilation. However, his condition also gradually improved over time. The present case suggests that an emergency CS could rescue both the mother, who was in critical condition, and the prematurely born baby, even when suffering from acute respiratory insufficiency.

    DOI: 10.2169/internalmedicine.8636-16

    Scopus

    PubMed

    researchmap

  • 脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

    山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 太田 康之, 阿部 康二

    Anti-aging Science   8 ( 1 )   72 - 72   2016.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • アルツハイマー病患者におけるガランタミンの長期的効果について

    中野 由美子, 山下 徹, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    Anti-aging Science   8 ( 1 )   69 - 69   2016.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • 難病患者就労に対する山陽神経難病ネットワークの役割

    太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 阿部 康二, 三宅 進, 重實 比呂子, 三村 あゆみ, 三垣 亮輔, 竹内 秀将, 岩藤 弘子, 薮田 智子, 斎藤 文恵, 鈴木 美穂, 竹内 ひかり

    日本難病医療ネットワーク学会機関誌   4 ( 1 )   61 - 61   2016.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • ラット一過性脳虚血モデルにおけるTDP43とFUS/TLSの発現亢進による神経細胞保護効果について

    中野 由美子, Sun Miao, 山下 徹, 森原 隆太, 武本 麻美, 佐藤 恒太, 菱川 望, 太田 康之, 阿部 康二

    脳循環代謝   28 ( 1 )   232 - 232   2016.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • PDDとDLB患者の認知機能・情動機能・日常生活活動強度の比較

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10回   88 - 88   2016.10

     More details

    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

    researchmap

  • 多発脳神経麻痺が急速に進行した腎癌の頭蓋底転移の1剖検例

    武本 麻美, 河原 由子, 佐藤 恒太, 佐藤 康晴, 太田 康之, 菱川 望, 山下 徹, 阿部 康二

    日本老年医学会雑誌   53 ( 4 )   461 - 461   2016.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • Asidan(ALS/SCA crossroad mutation)はSWEDDsと正反対所見DWEPを呈する

    阿部 康二, 太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10回   84 - 84   2016.10

     More details

    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

    researchmap

  • Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain Reviewed

    Qian Li, Yumiko Nakano, Jingwei Shang, Yasuyuki Ohta, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   25 ( 10 )   2344 - 2351   2016.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER  

    Background: Stress proteins have been found to play important protective roles against ischemic brain injury under hypoxic, oxidative, heat shock, and proteasome stresses. Methods: In the present study, we investigated the temporal profiles of the major stress proteins including hypoxia-inducible factor-1 alpha (HIF-1 alpha), glutathione (GSH), heat shock protein 72 (HSP72), constitutive heat shock cognate protein 73 (HSC73), and ubiquitin after 45 minutes of transient middle cerebral artery occlusion (tMCAO) in the mice brain up to 7 days after reperfusion. Results: Immunohistochemical analyses of HIF-1 alpha, GSH, HSP72, and ubiquitin showed little immunoreactivity of neural cells in sham control brain, whereas HSC73 showed a constitutive immunoreactivity. After tMCAO, HSC73 showed the fastest increase at 12 hours in the peri-ischemic area, followed by HIF-1 alpha with a peak at 24 hours, GSH, HSP72, and ubiquitin with a peak at 72 hours. All these stress proteins returned toward the baseline levels until 7 days. In the ischemic core, these stress proteins showed a similar change with less reaction compared to the peri-ischemic area. Conclusions: These data showed temporal expressions of HIF-1 alpha, GSH, HSP72, HSC73, and ubiquitin in the mice brain after tMCAO, which might provide a better understanding of neuroprotective mechanisms and novel targets for therapeutic intervention of brain ischemic disease. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.jstrokecerebrovasdis.2016.05.031

    Web of Science

    researchmap

  • Differences between the behavioral and psychological symptoms of Alzheimer's disease and Parkinson's disease Reviewed

    Ryo Tokuchi, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Yusuke Fukui, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   369   278 - 282   2016.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Aim: We compared the behavioral and psychological symptoms of Alzheimer's disease (AD) and Parkinson's disease (PD) in order to determine the characteristic features of each disorder.Methods: For this retrospective cohort study, we compared the behavioral and psychological symptoms of 288 AD patients and 189 PD patients (mean age, 74.6 +/- 5.9 and 73.0 +/- 8.7 years respectively). Symptoms were evaluated using the geriatric depression scale (GDS), apathy scale (AS), and Abe's behavioral and psychological symptoms of dementia score (ABS).Results: AD patients had higher AS and ABS scores than PD patients. A gender-dependent comparison showed that ABS scores were worse in female AD patients than in female PD patients (p=0.001). A subscale analysis of ABS scores revealed that male AD patients were only significantly different from male PD patients in I item, whereas female AD patients were significantly different from female PD patients in 4 items. Among patients with mild cognitive decline, no differences in affective scores were observed. Alternatively, among patients with moderate cognitive decline, affective scores on all 3 scales were worse in PD patients than in AD patients.Conclusions: The present age-and gender-matched retrospective analysis identified greater behavioral and psychological disease severity in female AD patients relative to female PD patients, and greater affective severity in PD patients versus AD patients with a similar degree of cognitive decline. (C) 2016 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jns.2016.08.053

    Web of Science

    researchmap

  • Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease Reviewed

    Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    European Neurology   75 ( 5-6 )   282 - 289   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    © 2016 S. Karger AG, Basel. Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients.

    DOI: 10.1159/000445111

    Scopus

    PubMed

    researchmap

  • 脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

    山下 徹, 菱川 望, 佐藤 恒太, 武本 麻美, 太田 康之, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   16回   191 - 191   2016.6

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • Age-dependent cognitive and affective differences in Alzheimer's and Parkinson's diseases in relation to MRI findings Reviewed

    Ryo Tokuchi, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Yusuke Fukui, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   365   3 - 8   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    Objective: To compare age-dependent changes in cognitive and affective functions related to white matter changes between patients with Alzheimer's disease (AD) and Parkinson's disease (PD).Methods: We retrospectively compared age-dependent cognitive and affective functions in 216 AD patients, 153 PD patients, and 103 healthy controls with cerebral white matter lesions (WMLs), periventricular hyperintensity (PVH), deep white matter hyperintensity (DWMH), micro-bleeds (MBs), and lacunar infarcts (LIs).Results: The average mini-mental state examination (MMSE) scores were 19.6 +/- 6.1 and 26.8 +/- 3.6 in AD and PD patients, respectively. Significant decreases were found in the MMSE score, Hasegawa's dementia scale-revised (HDS-R) score, frontal assessment battery score, and Abe's BPSD score (ABS) among the age-dependent AD subgroups and in the MMSE, HDS-R, Montreal cognitive assessment, geriatric depression scale, and ABS scores among the age-dependent PD subgroups; they were worse in AD patients. White matter changes were observed in > 88% and > 72% of patients with AD and PD, respectively. An age-dependent direct comparison of AD and PD showed significant differences in the PVH and DWMH grades, and numbers of MBs and LIs.Conclusion: WML-related cognitive and affective functions worsen with age in AD and PD patients; however, the abnormalities were more frequent and stronger in AD patients. (C) 2016 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jns.2016.03.031

    Web of Science

    researchmap

  • New susceptible variant of COQ2 gene in Japanese patients with sporadic multiple system atrophy

    Zhuoran Sun, Yasuyuki Ohta, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

    Neurology: Genetics   2 ( 2 )   2016.4

     More details

    Publishing type:Research paper (scientific journal)  

    © 2016 American Academy of Neurology. Objective: The aim of this study was to analyze the association between the variations of coenzyme Q2 4-hydroxybenzoate polyprenyltransferase gene (COQ2) and Japanese patients with multiple system atrophy (MSA). Methods: We investigated the genetic variations in exons 1, 2, 6, and 7 of the COQ2 gene in 133 Japanese patients with MSA and 200 controls and analyzed the association between the variations and MSA. Results: Six DNA variations (G21S, L25V, V66L, P157S, V393A, and X422K) were found in the 133 patients with MSA, and G21S and X422K were new variations that had never been reported. V66L was a common variation that was found in all 133 patients with MSA. G21S, P157S, V393A, and X422K did not show gene frequency differences between patients with MSA and controls. On the other hand, L25V was newly proven to be the only risk factor of sporadic MSA with predominant olivopontocerebellar ataxia. Conclusions: The present study suggests L25V variant of COQ2 gene as a genetic risk factor in Japanese patients with MSA with cerebellar ataxia.

    DOI: 10.1212/NXG.0000000000000054

    Scopus

    researchmap

  • Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease

    Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

    EUROPEAN NEUROLOGY   75 ( 5-6 )   282 - 289   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000445111

    Web of Science

    researchmap

  • Different Clinical and Neuroimaging Characteristics in Early Stage Parkinson's Disease with Dementia and Dementia with Lewy Bodies Reviewed

    Mami Takemoto, Kota Sato, Noriko Hatanaka, Toru Yamashita, Yasuyuki Ohta, Nozomi Hishikawa, Koji Abe

    JOURNAL OF ALZHEIMERS DISEASE   52 ( 1 )   205 - 211   2016

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:IOS PRESS  

    Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) both commonly exhibit brain Lewy body pathology and similar end-stage symptoms, but early symptoms differ. To clarify these differences, we compared the demographic characteristics, symptoms, cognitive and affective functioning, activities of daily life, and neuroimaging results between PDD (n = 52) and DLB (n = 46) patients. In measures of cognitive functioning, PDD patients had worse Hasegawa dementia scale-revised (HDS-R) scores (11.2 +/- 4.8) and better frontal assessment battery (FAB) scores (11.3 +/- 4.1) compared with DLB (17.0 +/- 6.4, p = 0.013 and 8.6 +/- 4.7, p = 0.039, respectively). DLB patients performed worse than PDD patients in "orientation to place" tasks. In affective functions, DLB patients had worse GDS (7.6 +/- 3.4) and ABS (9.9 +/- 5.3) scores than PDD patients (5.1 +/- 4.1 and 4.8 +/- 3.0, respectively). Tc-99m-ECD images showed greater CBF in the whole cingulate gyrus and a lower CBF in the precuneus area in DLB than in PDD. These results suggest that PDD patients' lower average scores for "repetition" (MMSE), "recent memory" (HDS-R), and "lexical fluency" (FAB) were related to lower CBF in the cingulate gyrus than in DLB. Furthermore, DLB patients' poorer average subscale scores of " orientation to place" (MMSE) and "similarities", "conflicting instructions", and "go-no go" (FAB) tasks may be related to the lower CBF in the precuneus area in DLB than PDD.

    DOI: 10.3233/JAD-150952

    Web of Science

    researchmap

  • 多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の有用性

    太田 康之, 河原 由子, 薮田 智子, 竹内 ひかり, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   3 ( 1 )   55 - 55   2015.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 脳卒中慢性期患者では再発よりも認知症移行(direct conversion)が高い

    中野 由美子, 出口 健太郎, 山下 徹, 武本 麻美, 佐藤 恒太, 菱川 望, 太田 康之, 高尾 芳樹, 東 靖人, 阿部 康二

    脳循環代謝   27 ( 1 )   149 - 149   2015.10

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • 進行性核上性麻痺・パーキンソン病患者における歩行の比較

    幡中 典子, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   9回   81 - 81   2015.10

     More details

    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

    researchmap

  • テルミサルタン長期投与がラット梗塞後脳に及ぼすメタボリックシンドローム関連因子発現の検討

    出口 健太郎, ざい 蘊, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    脳循環代謝   27 ( 1 )   195 - 195   2015.10

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • 多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の検討

    太田 康之, 河原 由子, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    Dementia Japan   29 ( 3 )   404 - 404   2015.9

     More details

    Language:Japanese   Publisher:(一社)日本認知症学会  

    researchmap

  • PDDとDLBの認知機能、情動機能の比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    日本神経心理学会総会プログラム・予稿集   39回   204 - 204   2015.8

     More details

    Language:Japanese   Publisher:日本神経心理学会  

    researchmap

  • MCIの予後と関連因子の検討

    徳地 亮, 菱川 望, 佐藤 恒太, 幡中 典子, 武本 麻美, 福井 裕介, 太田 康之, 山下 徹, 阿部 康二

    日本抗加齢医学会総会プログラム・抄録集   15回   190 - 190   2015.5

     More details

    Language:Japanese   Publisher:(一社)日本抗加齢医学会  

    researchmap

  • タッチパネル式コンピュータを活用した脳梗塞既往患者の認知機能と画像所見の関連の検討

    出口 健太郎, 河野 祥一郎, 柚木 太淳, 松薗 構佑, 中野 由美子, 角田 慶一郎, 河原 由子, 幡中 典子, 武本 麻美, 太田 康之, 菱川 望, 山下 徹, 阿部 康二

    脳循環代謝   26 ( 1 )   168 - 168   2014.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • 側頭葉内側萎縮と大脳白質病変の併存がアルツハイマー病患者の認知機能と情動機能に及ぼす影響

    徳地 亮, 菱川 望, 佐藤 恒太, 幡中 典子, 武本 麻美, 福井 裕介, 太田 康之, 出口 健太郎, 山下 徹, 阿部 康二

    脳循環代謝   26 ( 1 )   214 - 214   2014.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

▼display all

Books

  • 厚生労働科学研究補助金(難治性疾患克服研究事業)「運動失調症の医療基盤に関する調査研究」班平成29年度班会議(東京)

    阿部康二、山下徹、下澤伸行、佐藤恒太、武本麻美、菱川望、商敬偉、太田康之( Role: Joint author)

    厚生労働科学研究補助金(難治性疾患克服研究事業)「運動失調症の医療基盤に関する調査研究」班  2018.1 

     More details

    Language:Japanese

    researchmap

MISC

  • ALS患者脊髄では低酸素ストレスの増加が起きている

    山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

    神経治療学(Web)   38 ( 6 )   2021

  • 幹細胞移植は脳梗塞後の異常蛋白処理機構を変化させる

    田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二

    神経治療学(Web)   38 ( 6 )   2021

  • 機械的血栓回収による直接的血管損傷とNVU破綻 ラットモデルにおける検討

    佐々木諒, 山下徹, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 阿部康二

    神経治療学(Web)   38 ( 6 )   2021

  • 新しい臨床医療福祉に重要な視線計測計とAI技術

    阿部康二, 田所功, 福井裕介, 武本麻美, 森原隆太, 山下徹

    日本臨床医療福祉学会プログラム・抄録集   19th   2021

  • 脳梗塞モデルマウスにおけるホヤ由来プラズマローゲンの神経保護作用の検討

    福井裕介, 馮田, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 阿部康二

    脳循環代謝(Web)   33 ( 1 )   2021

  • TTN missense variants in two siblings with asymmetric facial and limb weakness

    Ryo Sasaki, Yasuyuki Ohta, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Theerawat Kumutpongpanich, Ichizo Nishino, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   415   2020.8

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER  

    DOI: 10.1016/j.jns.2020.116885

    Web of Science

    researchmap

  • "もの忘れ外来"通院患者の通院脱落に関わる因子

    菱川 望, 表 芳夫, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    日本老年医学会雑誌   57 ( Suppl. )   112 - 112   2020.7

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 抗酸化サプリメントTwendee Xの軽度認知障害に対する効果についての検討

    松本 菜見子, 田所 功, 森原 隆太, 太田 康之, 菱川 望, 川野 公子, 武本 麻美, 山下 徹, 犬房 春彦, 阿部 康二

    日本老年医学会雑誌   57 ( Suppl. )   113 - 113   2020.7

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 体重減少が先行しAutoimmune GFAP astrocytopathyと診断したステロイド反応性脳脊髄炎の一例

    小坂田 陽介, 池上 憲, 菱川 望, 佐藤 恒太, 表 芳夫, 武本 麻美, 太田 康之, 山下 徹, 木村 暁夫, 阿部 康二

    臨床神経学   60 ( 5 )   384 - 384   2020.5

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • A novel homoplasmic mitochondrial DNA mutation (m.13376T > C, p.1347T) of MELAS presenting characteristic medial temporal lobe atrophy

    Ryo Sasaki, Yasuyuki Ohta, Noriko Hatanaka, Koh Tadokoro, Emi Nomura, Jingwei Shang, Mami Takemoto, Nozomi Hishikaw, Toru Yamashita, Yoshio Omote, Eisaku Morimoto, Sanae Teshigawara, Jun Wada, Yu-ichi Goto, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   408   2020.1

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER  

    DOI: 10.1016/j.jns.2019.116460

    Web of Science

    researchmap

  • 幹細胞移植による虚血脳のタンパク分解分子機構への影響

    田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

    神経治療学(Web)   37 ( 6 )   2020

  • 幹細胞移植による虚血脳のタンパク分解分子機構への影響

    田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

    脳循環代謝(Web)   32 ( 1 )   2020

  • DTTを用いた小脳遠心路・求心路の検討~多系統萎縮症と皮質性小脳萎縮症の比較~

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本脳神経CI学会総会プログラム・抄録集(Web)   43rd   2020

  • Tractographyを用いた筋萎縮性側索硬化症における頚髄側索錐体路の損傷評価

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本脳神経CI学会総会プログラム・抄録集(Web)   43rd   2020

  • トラクトグラフィーを用いたALSにおける頸髄側索錐体路の損傷評価

    福井裕介, 福井裕介, 菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

    日本神経学会学術大会プログラム・抄録集   61st   2020

  • 抗酸化サプリメントTwendee Xによる認知機能低下予防効果 多施設共同前向き無作為化プラセボ対照二重盲検比較試験

    犬房 春彦, 田所 功, 森原 隆太, 太田 康之, 商 敬偉, 表 芳夫, 武本 麻美, 菱川 望, 山下 徹, 吉川 敏一, 阿部 康二

    機能性食品と薬理栄養   13 ( 3 )   173 - 173   2019.12

     More details

    Language:Japanese   Publisher:(株)インフォノーツパブリッシング  

    researchmap

  • 脳卒中マウスモデルにおけるTocotrienol製剤前投与の治療効果

    山下 徹, 商 敬偉, 馮 田, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    Anti-aging Science   11 ( 1 )   65 - 65   2019.12

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • 岡山県におけるレスパイト入院事業の検討

    川野 公子, 武本 麻美, 松本 茂樹, 松井 泰和, 鳥越 有子, 下山 英治, 角 紗綾果, 表 芳夫, 太田 康之, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   7 ( 1 )   126 - 126   2019.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 見逃したくない治療可能な小脳性運動失調症 PEX10変異による小脳失調症

    山下 徹, 三井 純, 下澤 伸行, 高島 茂雄, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 松川 敬志, 石浦 浩之, 吉村 淳, 土井 晃一郎, 森下 真一, 辻 省次, 阿部 康二

    臨床神経学   59 ( Suppl. )   S45 - S45   2019.11

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 胸髄の硬膜欠損を生じた脳表ヘモジデリン沈着症の一例

    平 佑貴, 池上 憲, 佐藤 恒太, 小坂田 陽介, 菱川 望, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    臨床神経学   59 ( 10 )   673 - 673   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 痙性対麻痺と末梢神経障害を合併したKleinfelter症候群に対する治療の検討

    佐々木 諒, 太田 康之, 田所 功, 佐藤 恒太, 菱川 望, 武本 麻美, 山下 徹, 阿部 康二

    神経治療学   36 ( 6 )   S276 - S276   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • 新規酸化ストレスイメージングによるALSマウスへのエダラボン治療効果の検討

    太田 康之, 野村 恵美, 山下 徹, 馮 田, 佐藤 恒太, 武本 麻美, 菱川 望, 表 芳夫, 阿部 康二

    神経治療学   36 ( 6 )   S269 - S269   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • 早期認知症診断に有用な新しい簡易BPSDスコア(阿部式BPSDスコア=ABS)

    阿部 康二, 菱川 望, 武本 麻美, 表 芳夫, 太田 康之, 山下 徹

    日本早期認知症学会誌   12 ( 3 )   41 - 41   2019.10

     More details

    Language:Japanese   Publisher:日本早期認知症学会  

    researchmap

  • A unique Japanese CPEO family with a novel homozygous m.14819 T > G (p. S25A) substitution

    Emi Nomura, Yasuyuki Ohta, Koh Tadokoro, Kota Sato, Ryo Sasaki, Yoshiaki Takahashi, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yu-ichi Goto, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   400   145 - 147   2019.5

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2019.03.029

    Web of Science

    researchmap

  • In Vivo Direct Reprogramming of Glial Linage to Mature Neurons in Post-stroke Brain

    Toru Yamashita, Jingwei Shang, Yumiko Nakano, Ryuta Morihara, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    CEREBROVASCULAR DISEASES   48   110 - 110   2019

     More details

    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:KARGER  

    Web of Science

    researchmap

  • 成人後にnonconvulsive status epilepticusが頻回に発生し初めて診断に至った環状20番染色体症候群の一例

    池上 憲, 佐藤 恒太, 小坂田 陽介, 菱川 望, 幡中 典子, 武本 麻美, 山下 徹, 太田 康之, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   150 - 150   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 中国四国地区におけるプリオン病の実態

    佐藤 恒太, 商 敬偉, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   149 - 149   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 進行性核上性麻痺患者とパーキンソン病患者における歩行の比較

    幡中 典子, 佐藤 恒太, 菱川 望, 武本 麻美, 商 敬偉, 太田 康之, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   137 - 137   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 新規SETX遺伝子変異を認めたAOA2患者の療養の検討

    野村 恵美, 山下 徹, 角田 慶一郎, 高橋 義秋, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 橋口 昭大, 高橋 博, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   134 - 134   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 地域で支える難病ネットワーク 山陽地区神経難病ネットワークについて

    武本 麻美, 太田 康之, 山下 徹, 菱川 望, 佐藤 恒太, 川野 公子, 阿部 康二

    日本難病医療ネットワーク学会機関誌   6 ( 1 )   65 - 65   2018.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 診断に苦慮した長大な脊髄病変を呈した1例の検討

    佐藤 恒太, 太田 康之, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    神経治療学   35 ( 6 )   S220 - S220   2018.11

     More details

    Language:Japanese   Publisher:(一社)日本神経治療学会  

    researchmap

  • Congenital myopathy with fiber-type disproportion accompanied by dilated cardiomyopathy in a patient with a novel p.G48A ACTA1 mutation

    Koh Tadokoro, Yasuyuki Ohta, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Kazufumi Nakamura, Ichizo Nishino, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   393   142 - 144   2018.10

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2018.08.015

    Web of Science

    researchmap

  • MRI・ドパミントランスポーター(DAT)イメージングでパーキンソニズムの左右差に合致した異常所見を認めた日本脳炎の一例

    田所 功, 太田 康之, 佐藤 恒太, 前木 孝洋, 佐々木 諒, 高橋 義秋, 商 敬偉, 武本 麻美, 菱川 望, 山下 徹, 田島 茂, 林 昌宏, 阿部 康二

    NEUROINFECTION   23 ( 2 )   232 - 232   2018.10

     More details

    Language:Japanese   Publisher:日本神経感染症学会  

    researchmap

  • MRI・ドパミントランスポーター(DAT)イメージングでパーキンソニズムの左右差に合致した異常所見を認めた日本脳炎の一例

    田所 功, 太田 康之, 佐藤 恒太, 前木 孝洋, 佐々木 諒, 高橋 義秋, 商 敬偉, 武本 麻美, 菱川 望, 山下 徹, 田島 茂, 林 昌宏, 阿部 康二

    NEUROINFECTION   23 ( 2 )   232 - 232   2018.10

     More details

    Language:Japanese   Publisher:日本神経感染症学会  

    researchmap

  • "もの忘れ外来"患者の通院中断に関わる因子

    菱川 望, 中野 由美子, 森原 隆太, 武本 麻美, 商 敬偉, 佐藤 恒太, 山下 徹, 太田 康之, 阿部 康二

    Dementia Japan   32 ( 3 )   511 - 511   2018.9

     More details

    Language:Japanese   Publisher:(一社)日本認知症学会  

    researchmap

  • 早期認知症診療に有用な新しいBPSDスコア(阿部式BPSDスコア=ABS)の開発と評価者間信頼性

    阿部 康二, 山下 徹, 太田 康之, 菱川 望, 佐藤 恒太, 武本 麻美, 商 敬偉

    日本早期認知症学会誌   11 ( 3 )   54 - 54   2018.8

     More details

    Language:Japanese   Publisher:日本早期認知症学会  

    researchmap

  • ALSモデルマウス骨格筋における酸化ストレスの関与

    太田 康之, 野村 恵美, 山下 徹, 馮 田, 黄 永, 佐藤 恒太, 武本 麻美, 菱川 望, 阿部 康二

    日本筋学会学術集会プログラム・抄録集   4回   169 - 169   2018.8

     More details

    Language:Japanese   Publisher:日本筋学会  

    researchmap

  • A new familial distal myopathy in Japan with predominant upper extremities Reviewed

    Yoshiaki Takahashi, Yasuyuki Ohta, Ryo Sasaki, Kou Tadokoro, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Ichizo Nishino, Koji Abe

    Journal of the Neurological Sciences   390   205 - 207   2018.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1016/j.jns.2018.04.008

    Scopus

    PubMed

    researchmap

  • Two cases of late onset familial amyloid polyneuropathy with a Glu61Lys transthyretin variant

    Yumiko Nakano, Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Taro Yamashita, Yukio Ando, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   390   22 - 25   2018.7

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER  

    DOI: 10.1016/j.jns.2018.04.003

    Web of Science

    researchmap

  • A mild myopathy with anti-SRP plus anti-PL-12 antibodies successfully treated by oral steroid monotherapy

    Koh Tadokoro, Yasuyuki Ohta, Ryo Sasaki, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Keigo Hayashi, Michiko Morishita, Ichizo Nishino, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   388   7 - 9   2018.5

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2018.02.040

    Web of Science

    researchmap

  • A novel presenilin 1 mutation (Leu418Trp) associated with spasticity, parkinsonism, and white matter lesion in a dominant Alzheimer's family

    Yoshiaki Takahashi, Yasuyuki Ohta, Ryo Sasaki, Kou Tadokoro, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takashi Haraguchi, Takeshi Ikeuchi, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   387   166 - 169   2018.4

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2018.01.006

    Web of Science

    researchmap

  • PDDとDLBの比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    日本老年医学会雑誌   54 ( 4 )   624 - 624   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 右海綿静脈洞から下垂体部膿瘍に脳室穿破を伴い治療に難渋した細菌性髄膜炎の1例

    高橋 義秋, 山下 徹, 佐々木 諒, 田所 功, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    日本老年医学会雑誌   54 ( 4 )   626 - 626   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 進行性核上性麻痺・パーキンソン病患者における歩行動作の比較

    幡中 典子, 佐藤 恒太, 菱川 望, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    日本老年医学会雑誌   54 ( 4 )   626 - 626   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 電話相談による認知症患者と介護者のためのサポートシステムについて おかやま認知症コールセンターの役割

    中野 由美子, 菱川 望, 坂本 恵子, 明楽 陽子, 尾崎 善規, 武本 麻美, 佐藤 恒太, 山下 徹, 太田 康之, 阿部 康二

    日本老年医学会雑誌   54 ( 4 )   625 - 625   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • 摂食嚥下機能改善により食べる楽しみの獲得に至った症例

    樋之津 健二, 菱川 望, 福井 裕介, 幡中 典子, 武本 麻美, 佐藤 恒太, 太田 康之, 山下 徹, 阿部 康二

    日本老年医学会雑誌   54 ( 4 )   624 - 624   2017.10

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • アパシースケールが他覚的評価に有用であった硬膜動静脈瘻の1例

    中野 由美子, 野村 恵美, 平松 匡文, 山下 徹, 武本 麻美, 商 敬偉, 佐藤 恒太, 太田 康之, 杉生 憲司, 阿部 康二

    日本神経心理学会総会プログラム・予稿集   41回   115 - 115   2017.9

     More details

    Language:Japanese   Publisher:日本神経心理学会  

    researchmap

  • 岡山県におけるレスパイト入院の現状

    川野 公子, 齋藤 文恵, 太田 康之, 大塚 貴子, 重實 比呂子, 三村 あゆみ, 長尾 宜彦, 鳥越 有子, 竹内 秀将, 小寺 正樹, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   5 ( 1 )   96 - 96   2017.9

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 洞不全症候群が惹起されたMIBG正常のSWEDDsの一例

    幡中 典子, 菱川 望, 佐藤 恒太, 武本 麻美, 山下 徹, 太田 康之, 阿部 康二

    自律神経   54 ( 2 )   165 - 165   2017.6

     More details

    Language:Japanese   Publisher:日本自律神経学会  

    researchmap

  • V-Pシャントで改善した、聴神経鞘腫による二次性水頭症の一例

    高橋 義秋, 太田 康之, 角田 慶一郎, 佐々木 諒, 田所 功, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    臨床神経学   57 ( 5 )   253 - 253   2017.5

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 検診患者における認知機能障害の有病率とその特徴について

    中野 由美子, 菱川 望, 福井 裕介, 武本 麻美, 佐藤 恒太, 山下 徹, 太田 康之, 阿部 康二

    日本老年医学会雑誌   54 ( Suppl. )   220 - 220   2017.5

     More details

    Language:Japanese   Publisher:(一社)日本老年医学会  

    researchmap

  • A patient with slowly progressive adult-onset nemaline myopathy and novel compound heterozygous mutations in the nebulin gene

    Keiichiro Tsunoda, Toru Yamashita, Emi Motokura, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Atsuko Nishikawa, Ichizo Nishino, Koji Abe

    Journal of the Neurological Sciences   373   254 - 257   2017.2

     More details

    Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1016/j.jns.2016.12.069

    Scopus

    PubMed

    researchmap

  • A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis

    Kota Sato, Keiichiro Tsunoda, Toru Yamashita, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toshiyuki Takahashi, Ichiro Nakashima, Takao Yasuhara, Isao Date, Koji Abe

    Journal of the Neurological Sciences   373   152 - 154   2017.2

     More details

    Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1016/j.jns.2016.12.040

    Scopus

    PubMed

    researchmap

  • Marked hypertriglyceridemia induced by interferon-beta 1a therapy in a clinically isolated syndrome patient Reviewed

    Yuko Kawahara, Toru Yamashita, Yasuyuki Ohta, Kota Sato, Keiichiro Tsunoda, Mami Takemoto, Nozomi Hishikawa, Jun Eguchi, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   373   144 - 146   2017.2

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2016.12.052

    Web of Science

    researchmap

  • An AOA2 patient with a novel compound heterozygous SETX frame shift mutations Reviewed

    Emi Motokura, Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Akihiro Hashiguchi, Hiroshi Takashima, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   372   294 - 296   2017.1

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2016.11.074

    Web of Science

    researchmap

  • 岡山県におけるレスパイト入院事業の現状

    薮田 智子, 斎藤 文恵, 太田 康之, 竹内 ひかり, 岩藤 弘子, 古好 正徳, 竹内 秀将, 森本 健介, 三垣 亮輔, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    臨床神経学   56 ( Suppl. )   S259 - S259   2016.12

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 進行性核上性麻痺・パーキンソン病患者における歩行の検討

    幡中 典子, 佐藤 恒太, 菱川 望, 武本 麻美, 太田 康之, 山下 徹, 阿部 康二

    臨床神経学   56 ( Suppl. )   S446 - S446   2016.12

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 認知症発症初期段階のPDDとDLBの比較検討

    武本 麻美, 菱川 望, 太田 康之, 山下 徹, 佐藤 恒太, 幡中 典子, 阿部 康二

    臨床神経学   56 ( Suppl. )   S442 - S442   2016.12

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 高度の洞不全症候群が惹起されたMIBG正常のSWEDDsの一例

    幡中 典子, 菱川 望, 佐藤 恒太, 武本 麻美, 山下 徹, 太田 康之, 阿部 康二

    日本自律神経学会総会プログラム・抄録集   69回   102 - 102   2016.11

     More details

    Language:Japanese   Publisher:日本自律神経学会  

    researchmap

  • 岡山県におけるレスパイト入院事業の現状

    鈴木 美穂, 薮田 智子, 齋藤 文恵, 太田 康之, 竹内 ひかり, 重實 比呂子, 三村 あゆみ, 三垣 亮輔, 竹内 秀将, 岩藤 弘子, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   4 ( 1 )   91 - 91   2016.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • An autopsy case of intravascular large B-cell lymphoma with subcortical U-fiber sparing and unique lymphocyte markers Reviewed

    Kota Sato, Emi Motokura, Kentaro Deguchi, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Junya Itakura, Koji Abe

    Journal of the Neurological Sciences   369   273 - 275   2016.10

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1016/j.jns.2016.08.051

    Scopus

    PubMed

    researchmap

  • 新規SETX遺伝子変異を認めたAOA2の一例

    本倉 恵美, 山下 徹, 角田 慶一郎, 高橋 義秋, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 橋口 昭大, 高嶋 博, 阿部 康二

    臨床神経学   56 ( 10 )   720 - 720   2016.10

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 全く異なる初発症状を認めたPARK2の同胞2症例

    佐藤 恒太, 幡中 典子, 太田 康之, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   10回   78 - 78   2016.10

     More details

    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

    researchmap

  • Different clinical features in siblings with identical mutations of the Parkin gene (PARK2) Reviewed

    Kota Sato, Toru Yamashita, Noriko Hatanaka, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   368   147 - 149   2016.9

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2016.07.004

    Web of Science

    researchmap

  • Recurrent cervical internal carotid artery vasospasm relating to menstruation with endothelial dysfunction Reviewed

    Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Torts Yamashita, Koji Abe

    JOURNAL OF THE NEUROLOGICAL SCIENCES   365   72 - 73   2016.6

     More details

    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:ELSEVIER SCIENCE BV  

    DOI: 10.1016/j.jns.2016.03.044

    Web of Science

    researchmap

  • 再発性多発性脳幹病変を呈しCLIPPERS症候群が疑われた一例

    本倉 恵美, 山下 徹, 角田 慶一郎, 高橋 義秋, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    臨床神経学   56 ( 3 )   229 - 229   2016.3

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 緊急帝王切開により母子救命できた抗MuSK抗体陽性重症筋無力症クリーゼの一例

    高橋 義秋, 山下 徹, 本倉 恵美, 角田 慶一郎, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 阿部 康二

    臨床神経学   56 ( 3 )   232 - 232   2016.3

     More details

    Language:Japanese   Publisher:(一社)日本神経学会  

    researchmap

  • 脳卒中慢性期患者に高頻度で生じる認知症移行(direct conversion)について

    中野 由美子, 出口 健太郎, 山下 徹, 武本 麻美, 佐藤 恒太, 菱川 望, 太田 康之, 高尾 芳樹, 東 靖人, 阿部 康二

    Anti-aging Science   7 ( 3 )   195 - 195   2015.11

     More details

    Language:Japanese   Publisher:(株)メディカルレビュー社  

    researchmap

  • 未破裂脳動脈瘤コイル塞栓術後に多発性の大脳病変を呈した一例

    出口 健太郎, 出口 章子, 河原 由子, 佐藤 恒太, 武本 麻美, 菱川 望, 太田 康之, 山下 徹, 徳永 浩司, 杉生 憲志, 河井 信行, 阿部 康二

    JNET: Journal of Neuroendovascular Therapy   9 ( 6 )   S358 - S358   2015.11

     More details

    Language:Japanese   Publisher:(NPO)日本脳神経血管内治療学会  

    researchmap

  • 岡山県におけるレスパイト入院事業の検討

    薮田 智子, 太田 康之, 竹内 ひかり, 岩藤 弘子, 古好 正徳, 竹内 秀将, 森本 健介, 三垣 亮輔, 佐藤 恒太, 武本 麻美, 菱川 望, 山下 徹, 阿部 康二

    日本難病医療ネットワーク学会機関誌   3 ( 1 )   89 - 89   2015.11

     More details

    Language:Japanese   Publisher:日本難病医療ネットワーク学会  

    researchmap

  • 阿部式BPSDスコア(ABS)の開発と評価者間信頼性の検討

    阿部 康二, 中野 由美子, 武本 麻美, 菱川 望, 佐藤 恒太, 太田 康之, 山下 徹

    日本神経心理学会総会プログラム・予稿集   39回   142 - 142   2015.8

     More details

    Language:Japanese   Publisher:日本神経心理学会  

    researchmap

  • ロチゴチン経皮吸収型製剤により夜間から早朝にかけてのウェアリングオフ現象が劇的に改善した症例

    武本 麻美, 佐藤 恒太, 出口 健太郎, 山下 徹, 菱川 望, 太田 康之, 阿部 康二

    脳循環代謝   26 ( 1 )   194 - 194   2014.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

  • 軽度認知障害(MCI)の悪化(convert)および改善(revert)に関連する要因の検討

    徳地 亮, 菱川 望, 佐藤 恒太, 幡中 典子, 武本 麻美, 福井 裕介, 太田 康之, 出口 健太郎, 山下 徹, 阿部 康二

    脳循環代謝   26 ( 1 )   190 - 190   2014.11

     More details

    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

    researchmap

▼display all

 

Class subject in charge

  • advanced health sciences (2021academic year) Late  - その他