2024/09/25 更新

写真a

タカオ ソウシ
高尾 総司
TAKAO Soshi
所属
医歯薬学域 准教授
職名
准教授
ホームページ
外部リンク

学位

  • 博士(医学) ( 岡山大学 )

研究キーワード

  • Epidemiology

  • 疫学

研究分野

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

委員歴

  • 岡山県   健康おかやま21委員  

    2023年4月 - 現在   

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    団体区分:自治体

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  • 岡山労働局   労働衛生指導医  

    2021年5月 - 現在   

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    団体区分:政府

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  • 岡山産業保健総合支援センター   産業医学相談員  

    2010年4月 - 現在   

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    団体区分:その他

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論文

  • Kinetics of SARS-CoV-2 antibody titers after booster vaccinations during an Omicron surge in Japan

    Naomi Matsumoto, Ayako Sasaki, Tomoka Kadowaki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Vaccine   42 ( 21 )   126156 - 126156   2024年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.vaccine.2024.126156

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  • Pediatric otitis media in Japan: A nationwide longitudinal study of the pre- and post-pneumococcal conjugate vaccine eras born in 2001 and 2010. 国際誌

    Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    Vaccine   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Otitis media (OM) is a prevalent respiratory disease in children and poses significant public health challenges due to its impact on child health and economic burdens. However, there have no nationwide epidemiological studies conducted in Japan. This study investigates the epidemiological trends of OM in Japan, taking into account the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) introduction. METHOD: This study was retrospective cohort study using secondary data on the nationwide longitudinal birth cohort. This survey followed two cohorts born in 2001 (pre-PCV era) and 2010 (post-PCV era) until the age of 9. Every year, parents were surveyed about their children's health status, including occurrences of OM. The annual period prevalence and cumulative incidence of OM were assessed in this study, and the two cohorts were compared using a modified Poisson regression model adjusted environmental factors with the 2001 cohort as reference. RESULT: The study included 47,015 children from the 2001 cohort and 38,554 from the 2010 cohort. Peak annual period prevalence of OM varied by era. Cumulative incidence was 13.8 % for the 2001 cohort and 18.5 % for the 2010 cohort by 1.5 years of age and 28.9 % and 33.3 %, respectively, by 3.5 years of age. In particular, from the fourth survey onward, covering ages 2.5-3.5 years, a shift was observed from an increased risk to a decreased risk of OM. CONCLUSION: This nationwide longitudinal study emphasizes variations in OM epidemiology across Japan over time, with changes potentially influenced by the introduction of PCV7. In this study, due to the absence of individual PCV7 vaccination data, the effect of PCV7 was estimated based on the vaccination rate at the population level. The results suggest a notable decrease in the incidence of OM in later years, aligning with the increased uptake of PCV7.

    DOI: 10.1016/j.vaccine.2024.05.020

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  • Effect of COVID-19 Infection on Presenteeism: Cohort Study Using Large Health Insurance-Based Data in Japan. 国際誌

    Chikara Miyaji, Tomoko Kobayashi, Hiroshi Habu, Akikazu Hagiyama, Yoshiharu Horie, Soshi Takao

    Journal of occupational and environmental medicine   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Presenteeism occurs when employees attend work despite experiencing problems and ill-health that require sick leave. This study examined whether presenteeism worsened following COVID-19 infection. METHODS: We used the DeSC, a large health insurance claims database. Participants were 9,241 individuals who responded to questionnaires at baseline (June 2020) and 6 months later, had been continuously insured for at least 6 months prior to baseline, and reported being employed. Propensity score matching was performed. Adjusted multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of worsening presenteeism from baseline according to COVID-19 infection compared with non-infection. RESULTS: Conditional logistic regression analysis showed that the adjusted OR for presenteeism in the COVID-19 infected group was 1.555 (95% CI, 1.086-2.225). CONCLUSION: The findings suggest that COVID-19 infection affected worsening of presenteeism.

    DOI: 10.1097/JOM.0000000000003128

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  • Antibody titers and the risk of infection during the SARS-CoV-2 Omicron phase in Bizen City, Japan. 国際誌

    Tomoka Kadowaki, Ayako Sasaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

    The Journal of infectious diseases   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Understanding the association between the immune response and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has implications for forthcoming prevention strategies. We evaluated the association between antibody titers and the risk of infection for the general population during the Omicron-dominant phase. METHODS: This was a prospective cohort study of residents or people affiliated with institutions in Bizen City, which included 1,899 participants. We measured the titers of antibodies against SARS-CoV-2 repeatedly every 2 months from June 2022 to March 2023. Infection status was obtained from self-reported questionnaires and the official registry. We estimated risk ratios (RRs) for infection within 2 months of the date of each antibody measurement with 95% confidence intervals (CIs) based on antibody titer categories and spline functions. RESULTS: Compared with the <2,500 arbitrary unit (AU)/mL category, the 2,500-5,000, 5,000-10,000, and ≥10,000 AU/mL categories had adjusted RRs (95% CI) of 0.81 (0.61-1.08), 0.51 (0.36-0.72), and 0.41 (0.31-0.54), respectively. The spline function showed a non-linear relationship between antibody titer and risk. CONCLUSIONS: Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future vaccination.

    DOI: 10.1093/infdis/jiae207

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  • Longitudinal antibody dynamics after COVID-19 vaccine boosters based on prior infection status and booster doses

    Naomi Matsumoto, Ayako Sasaki, Tomoka Kadowaki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Scientific Reports   14 ( 1 )   2024年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Global concern over COVID-19 vaccine distribution disparities highlights the need for strategic booster shots. We explored longitudinal antibody responses post-booster during the Omicron wave in a Japanese cohort, emphasizing prior infection and booster doses. This prospective cohort study included 1763 participants aged 18 years and older with at least three vaccine doses (7376 datapoints). Antibody levels were measured every 2 months. We modeled temporal declines in antibody levels after COVID-19 vaccine boosters according to prior infection status and booster doses using a Bayesian linear mixed-effects interval-censored model, considering age, sex, underlying conditions, and lifestyle. Prior infection enhanced post-booster immunity (posterior median 0.346, 95% credible interval [CrI] 0.335–0.355), maintaining antibody levels (posterior median 0.021; 95% CrI 0.019–0.023) over 1 year, in contrast to uninfected individuals whose levels had waned by 8 months post-vaccination. Each additional booster was correlated with higher baseline antibody levels and slower declines, comparing after the third dose. Female sex, older age, immunosuppressive status, and smoking history were associated with lower baseline post-vaccination antibodies, but not associated with decline rates except for older age in the main model. Prior infection status and tailored, efficient, personalized booster strategies are crucial, considering sex, age, health conditions, and lifestyle.

    DOI: 10.1038/s41598-024-55245-9

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    その他リンク: https://www.nature.com/articles/s41598-024-55245-9

  • Longitudinal changes in antibody titers in a nursing home in which COVID-19 clusters occurred

    Tomoka Kadowaki, Ayako Sasaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    American Journal of Infection Control   2024年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ajic.2024.02.006

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  • Significance of Continuous Low-Dose Lenvatinib for the Treating of the Patients with Unresectable Thyroid Carcinoma.

    Daizo Murakami, Kohei Nishimoto, Soshi Takao, Satoru Miyamaru, Tomoka Kadowaki, Haruki Saito, Hiroki Takeda, Momoko Ise, Koichi Suyama, Yorihisa Orita

    Acta medica Okayama   78 ( 1 )   63 - 70   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma.

    DOI: 10.18926/AMO/66672

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  • Antibody levels and the risk of SARS-CoV-2 infection during the Omicron surge

    Ayako Sasaki, Tomoka Kadowaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    GHM Open   2024年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:National Center for Global Health and Medicine (JST)  

    DOI: 10.35772/ghmo.2023.01018

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  • Association Between Clinical Remission of Infantile-Onset Allergic Rhinitis During the School-Age Period and the Type of Housing: A Longitudinal Population-Based Japanese Study. 国際誌

    Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study investigated the association between housing type and clinical remission of infantile-onset allergic rhinitis (AR) in 53,575 children born in 2001 in Japan. Infantile-onset AR was defined as the presence of AR symptoms reported between ages 1.5 and 4.5 years, and remission was assessed between ages 10 and 12. The type of housing was categorized into detached houses and multi-unit residential buildings with 1-2, 3-5, or ≥6 floors. Among the 4,352 infantile-onset AR, 42.9% experienced remission. Notably, living in multi-unit residential buildings, particularly those with 1-2 and ≥6 floors, was positively associated with AR remission.

    DOI: 10.1016/j.pedhc.2023.11.011

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  • Review of a Series of Surveys on Adverse Reactions to the COVID-19 mRNA-1273 Vaccine at Okayama University.

    Naomi Matsumoto, Chigusa Higuchi, Chikara Miyaji, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

    Acta medica Okayama   77 ( 6 )   567 - 575   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.

    DOI: 10.18926/AMO/66148

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  • Fine particulate matter and diabetes prevalence in Okayama, Japan 査読 国際誌

    Tani Y, Kashima S, Mitsuhashi T, Suzuki E, Takao S, Yorifuji T

    Acta Medica Okayama   77 ( 6 )   607 - 612   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries.

    DOI: 10.18926/AMO/66152

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  • Effectiveness of the Original COVID-19 Vaccine against COVID-19 Exacerbations during the Omicron Wave: A Population-based Study in Okayama, Japan.

    Naomi Matsumoto, Toshiharu Mitsuhashi, Rumi Matsuo, Tomoka Kadowaki, Soshi Takao, Takashi Yorifuji

    JMA journal   6 ( 4 )   463 - 469   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: In Japan, approximately 97 million individuals have received their primary two doses of coronavirus disease 2019 (COVID-19) vaccine at the end of 2022. In this study, we aim to examine the effectiveness of the primary vaccines and compare its efficacy to booster vaccine shots in terms of preventing COVID-19 exacerbations during the Omicron-predominant period in Japan. METHODS: For this analysis, we have collected all the confirmed COVID-19-positive cases from different medical institutions in Okayama City and have also utilized the information from the public Vaccination Record System. Taking the number of vaccinations into consideration, we then conducted a population-based study to assess the effectiveness of the two primary vaccine doses in preventing COVID-19 exacerbations during the Omicron waves. Our primary and secondary outcomes were COVID-19 exacerbations with respiratory failure (i.e., oxygen saturation on room air ≤ 93%, requiring supplemental oxygen), intensive care unit admission and/or mechanical ventilator requirement, or death, in accordance with the Japanese COVID-19 guidelines, and pneumonia during the course of COVID-19 infection, respectively. RESULTS: In total, 95,329 COVID-19-positive individuals, aged 5 years and above, were included in this analysis (study period from January 1 to September 10, 2022). As per our findings, the effectiveness of the primary two doses against COVID-19 exacerbations compared with those who had never been vaccinated was 55.5% (95% confidential interval [CI]: 32.6-71.7), whereas it was higher after the third dose (76.9%; 95% CI: 66.7-84.0) and the fourth dose (75.7%; 95% CI: 58.8-85.7). Effectiveness was sustained for ≥ 5 months after the third vaccination, and preventive effectiveness was observed in individuals aged ≥ 65 years. CONCLUSIONS: As per the results of this study, we can conclude that the efficacy of the primary two doses of SARS-CoV-2 vaccine can be further strengthened in terms of preventing COVID-19 exacerbations by administering third and fourth booster vaccine shots. The additional bivalent vaccine is anticipated to further increase its efficacy against the Omicron strain, suggesting that individuals who have not received their booster shots yet should consider getting them to prevent COVID-19 exacerbations.

    DOI: 10.31662/jmaj.2023-0019

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  • Childcare and Child Development in Japan. 査読

    Murata A, Matsumoto N, Miyaji C, Takao S, Yorifuji T

    Acta Med Okayama.   77 ( 5 )   479 - 490   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/65970.

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  • Participation in the Setouchi Triennale and the Health of Residents in Naoshima: A Cross-Sectional Study 査読

    Habu H, Takao S, Miyaji C, Matsumoto N, Aoo K, Nishita Y, Tsuri M, Yorifuji T

    77 ( 5 )   491 - 497   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/65971.

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  • ASO Visual Abstract: EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery. 国際誌

    Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

    Annals of surgical oncology   30 ( 11 )   6705 - 6706   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-023-14005-1

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  • Does Participation in the Setouchi Triennale Foster Social Capital? : A Cross-Sectional Study.

    Chikara Miyaji, Soshi Takao, Hiroshi Habu, Naomi Matsumoto, Ken Aoo, Yosuke Nishita, Masao Tsuri, Takashi Yorifuji

    Acta medica Okayama   77 ( 5 )   443 - 449   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study examined whether participation in an art project was associated with higher social capital (SC). We conducted a questionnaire survey from November 2021 to March 2022 among residents aged 20 years or older of Naoshima, an island in Kagawa Prefecture, Japan. Before the survey, the Setouchi Triennale had been held on Naoshima four times, starting in 2010. We calculated propensity scores for Triennale participation and performed propensity score matching. We then compared cognitive and structural SC by Triennale participation and found significant differences, respectively. We adopted a conditional ordered logistic regression analysis with propensity score matching for cognitive or structural SC, and found adjusted odd ratios of 2.913 (95%CI, 1.846-4.596) for cognitive SC and 4.535 (95%CI, 2.839-7.244) for structural SC. Our findings suggest that Triennale participation enhanced the cognitive aspect of SC while also building structural SC.

    DOI: 10.18926/AMO/65966

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  • EGFR Mutation is a Prognostic Factor in Lung Cancer Patients with Pleural Dissemination Detected During or After Surgery. 国際誌

    Toshiya Fujiwara, Kazuhiko Shien, Motoki Matsuura, Junichi Soh, Hiromasa Yamamoto, Soshi Takao, Yuho Maki, Tsuyoshi Ueno, Ryujiro Sugimoto, Ken Suzawa, Mikio Okazaki, Hiroyuki Tao, Makio Hayama, Masafumi Kataoka, Yoshifumi Sano, Hidetoshi Inokawa, Motohiro Yamashita, Osamu Kawamata, Kazuhiko Kataoka, Shinichi Toyooka

    Annals of surgical oncology   30 ( 11 )   6697 - 6702   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Primary lung tumors are sometimes resected when either pleural dissemination (PD) or malignant pleural effusion (MPE) exists. This study clarified the prognostic factors for non-small cell lung cancer (NSCLC) with either PD and MPE, or both, detected during or after surgery. PATIENTS AND METHODS: We examined patients with NSCLC from a multicenter database who had either PD, MPE, or both, detected during or after surgery between 2005 and 2015. Hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model adjusted for potential confounding factors. RESULTS: Among 9463 registered patients, PD, MPE, or both, were found in 114 patients with NSCLC during or after surgery. Primary tumor resection and exploratory thoracotomy were performed in 65 and 49 patients, respectively. In univariate analysis, adenocarcinoma, clinically undetected lymph node metastasis (c-N0 or unknown), EGFR mutation, and combination of chemotherapy or tyrosine kinase inhibitors after surgery were better prognostic factors for overall survival (OS), whereas in the multivariate analysis, adenocarcinoma, clinically undetected lymph node metastasis, and EGFR mutation were favorable independent prognostic factors in OS. Additionally, limited to patients with EGFR mutation, patients with primary lung tumor resection showed a significantly better 5-year OS than those with exploratory thoracotomy (86.4 vs. 44.8%; p < 0.001). CONCLUSION: Our findings show that surgical resection of primary tumors could improve the prognosis of patients with PD, MPE, or both, detected during or after surgery when the tumors harbor an EGFR mutation.

    DOI: 10.1245/s10434-023-13791-y

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  • Antibody Titers After a Third and Fourth SARS-CoV-2 Vaccine Dose in Bizen City, Japan

    Tomoka Kadowaki, Ayako Sasaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Journal of Epidemiology   33 ( 9 )   484 - 486   2023年9月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20230034

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  • Endolymphatic Hydrops on Magnetic Resonance Imaging May Be an Independent Finding on Aging in Neurotologic Patients. 国際誌

    Yukihide Maeda, Katsuhide Kojima, Soshi Takao, Ryotaro Omichi, Shin Kariya, Mizuo Ando

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   44 ( 7 )   737 - 741   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To clarify whether age impacts the development of endolymphatic hydrops (ELH) in neurotologic patients. Documentation of ELH in living patients on magnetic resonance imaging (MRI) allows analysis of patient age and formation of ELH, which is impossible by means of postmortem temporal bone pathology. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Fifty patients (100 ears) with top 3 diagnoses of definite Menière's disease, delayed ELH, or probable Menière's disease. INTERVENTIONS: Endolymph MRI after intravenous gadolinium injection and pure-tone audiometry. MAIN OUTCOME MEASURES: Cochlear and vestibular ELH confirmed by MRI. RESULTS: The prevalences of ears showing both cochlear and vestibular ELH were similar among age groups <30 years (30%), 30-59 years (25.9%), and ≥60 years (34.4%; p > 0.05; χ2 test). Using logistic regression modeling, mean hearing level at the six frequencies was positively associated with a higher risk of cochlear ELH (odds ratio, 1.3; 95% confidence interval, 1.1-1.5 per 10-dB increment). In the same regression model, age did not impact the outcome of cochlear ELH (odds ratio, 1.0; 95%confidence interval, 0.7-1.4 per 10-year increment). Age did not differ among ears with no ELH (mean ± standard deviation age, 48.6 ± 14.4 yr), ears with only cochlear ELH (59.3 ± 10.7 yr), ears with only vestibular ELH (50.4 ± 16.9 yr), or ears with both cochlear and vestibular ELH (51.5 ± 18.4 yr; p > 0.05, analysis of variance). CONCLUSION: Chronological age was not associated with the formation of ELH. Aging per se may not be associated with the development of ELH in neurotologic patients.

    DOI: 10.1097/MAO.0000000000003945

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  • Obesity, overweight, and severe prognosis in COVID-19 patients in Japan

    Tomoka Kadowaki, Naomi Matsumoto, Rumi Matsuo, Toshiharu Mitsuhashi, Ayako Sasaki, Soshi Takao, Takashi Yorifuji

    Journal of Infection and Chemotherapy   2023年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.jiac.2023.08.004

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  • Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan

    Kataoka Takahiro, Habu Hiroshi, Tanaka Ayumi, Naoe Shota, Murakami Kaito, Fujimoto Yuki, Yukimine Ryohei, Takao Soshi, Mitsunobu Fumihiro, Yorifuji Takashi, Yamaoka Kiyonori

    77 ( 4 )   387 - 394   2023年8月

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    記述言語:英語   出版者・発行元:Okayama University Medical School  

    DOI: 10.18926/amo/65749

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  • Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan.

    Takahiro Kataoka, Hiroshi Habu, Ayumi Tanaka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Soshi Takao, Fumihiro Mitsunobu, Takashi Yorifuji, Kiyonori Yamaoka

    Acta medica Okayama   77 ( 4 )   387 - 394   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants' bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis.

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  • Comparison between olanzapine and aripiprazole treatment for 104 weeks after hospital discharge in schizophrenia spectrum disorders: a multicenter retrospective cohort study in a real-world setting

    Tomonari Hosokawa, Chikara Miyaji, Yusaku Yoshimura, Kenji Washida, Yuji Yada, Shinji Sakamoto, Yuko Okahisa, Soshi Takao, Akira Nomura, Yoshiki Kishi, Toshiki Harada, Manabu Takaki, Toshihiko Takeda, Norihito Yamada

    Psychopharmacology   2023年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s00213-023-06407-6

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  • Association between handwashing and gargling education for children and prevention of respiratory tract infections: a longitudinal Japanese children population-based study

    Kensuke Uraguchi, Toshiharu Mitsuhashi, Naomi Matsumoto, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

    European Journal of Pediatrics   2023年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s00431-023-05062-5

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  • Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy.

    Hiroki Ihara, Kotaro Yoshio, Shunsuke Tanabe, Soichi Sugiyama, Masashi Hashimoto, Naoaki Maeda, Shinsuke Akagi, Soshi Takao, Kazuhiro Noma, Takao Hiraki

    Esophagus : official journal of the Japan Esophageal Society   20 ( 3 )   548 - 556   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Surgical resection of esophageal cancer is frequently performed to achieve a complete cure. However, the postoperative recurrence rate is 36.8-42.5%, leading to poor prognosis. Radiation therapy has been used to treat recurrences; solitary recurrence has been proposed as a prognostic factor for radiation therapy, though its significance is unclear. 18F-fluorodeoxyglucose positron emission tomography is a highly accurate diagnostic modality for esophageal cancer. This retrospective study aimed to analyze the outcomes of solitary postoperative recurrences of esophageal squamous cell carcinoma diagnosed with 18F-fluorodeoxyglucose positron emission tomography and treated with definitive radiation therapy. METHODS: We examined 27 patients who underwent definitive radiation therapy for single or multiple postoperative recurrences of esophageal squamous cell carcinoma between May 2015 and April 2021. 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed within 3 months before the commencement of radiation therapy. Kaplan-Meier, univariate, and multivariate analyses were performed to examine the overall survival and identify potential prognostic factors. RESULTS: The 1-, 2-, and 3-year overall survival rates were 85.2%, 62.6%, and 47.3%, respectively, and solitary recurrence was the only significant factor associated with overall survival (P = 0.003). The 1-, 2-, and 3-year overall survival rates in patients with solitary recurrence were 91.7%, 80.2%, and 80.2%, respectively, and in patients with multiple recurrences they were 80.0%, 50.3%, and 25.1%, respectively. Multivariate analysis also showed solitary recurrence as a significant factor for overall survival. CONCLUSIONS: When diagnosed with 18F-fluorodeoxyglucose positron emission tomography/computed tomography, solitary recurrence appears to have a more favorable prognosis than multiple recurrences.

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  • Complementary and Alternative Medicine Use, Cancer Screening, and Medical Checkups in Japan from 2001 to 2013: A Repeated Cross-Sectional Study. 国際誌

    Nobuyoshi Matsuki, Etsuji Suzuki, Toshiharu Mitsuhashi, S V Subramanian, Soshi Takao, Takashi Yorifuji

    Journal of integrative and complementary medicine   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Introduction: The association between complementary and alternative medicine (CAM) use and other health-related behaviors is an important issue. A previous study reported that complementary medicine use is related to greater use of cancer screening, whereas alternative medicine use is related to lower use of cancer screening. Given the sparse evidence from Japan, we aimed to examine the association of CAM use with cancer screening and medical checkups. We used a repeated cross-sectional survey of a nationally representative sample of Japanese people and conducted age-period-cohort analysis. Methods: The study population was 68,217 of 83,827 individuals observed from 2001 to 2013 who received cancer screening. CAM users were defined as individuals who received acupuncture, moxibustion, anma/massage/shiatsu, or judo therapy for their most worrisome symptom. The outcomes of interest were receiving stomach, lung, colorectal, uterine, and breast cancer screenings and medical checkups. Using crossclassified multilevel logistic regression models, we estimated odds ratios (ORs) and 95% credible intervals (CIs) for cancer screening and medical checkups. Results: For CAM users of complementary medicine, the adjusted ORs for stomach, lung, and colorectal cancer screening were 1.40 (95% CI: 1.35-1.44), 1.37 (95% CI: 1.34-1.40), and 1.52 (95% CI: 1.49-1.54), respectively. We found similar results for uterine and breast cancer screening, and medical checkups. Conclusions: Irrespective of whether they use CAM, CAM users in Japan tend to receive a variety of cancer screenings and medical checkups.

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  • Breastfeeding at 6 months of age had a positive impact on overweight and obesity in Japanese adolescents at 15 years of age 国際誌

    Tomoka Kadowaki, Naomi Matsumoto, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Acta Paediatrica   112 ( 1 )   106 - 114   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    AIM: A number of studies have indicated the potential benefits that breastfeeding has on reducing childhood obesity, but few studies have evaluated the effect on adolescent obesity. We examined the association between breastfeeding and overweight or obesity at 15 years of age using data from a large nationwide longitudinal study launched by the Japanese Government in 2001. METHODS: We analysed data for 26 164 participants with known infant feeding practices at 6 months of age, namely the duration of breastfeeding or formula feeding. Overweight or obesity at 15 years of age were calculated based on the subject's self-reported height and weight. Multinomial logistic regression analysis adjusted the data for child factors, namely sex, siblings, birth weight and physical activity clubs and the maternal factors of age, educational attainment and smoking status. RESULTS: Formula feeding was associated with an increased risk of overweight or obesity at 15 years of age. The adjusted odds ratios (95% confidence intervals) were 0.99 (0.89-1.09) for partial breastfeeding and 1.23 (1.02-1.48) for formula feeding, when exclusive breastfeeding was the reference category. CONCLUSION: Breastfeeding during infancy had potential benefits for overweight or obesity among 15-year-old adolescents. Our results provide further evidence of the importance of breastfeeding.

    DOI: 10.1111/apa.16551

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  • Differential association of frailty with the incidence of mild and severe disability in older people: A 3-year cohort study. 国際誌

    Akikazu Hagiyama, Soshi Takao, Rumi Matsuo, Takashi Yorifuji

    Annals of geriatric medicine and research   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Frailty is associated with the incidence of disability in older people, but few studies investigated differences in the association of frailty with mild and severe disability by Japanese long-term care insurance certification. This study investigated the association of frailty with the incidence of mild and severe disability separately. METHODS: This was a retrospective cohort study for 3 years. The participants were community-dwelling people aged ≥ 65 in Okayama City. We assessed frailty status using the Kihon Checklist and defined outcomes as mild and severe disability in long-term care insurance certifications. Multinomial logistic regression analysis was used to investigate the association of frailty with the incidence of mild and severe disability. RESULTS: A total of 36043 participants were analyzed. For mild disability, the odds ratios (ORs) comparing frail to robust and prefrail to robust were 3.85 (95% confidence interval [CI] 3.36-4.42) and 1.82 (95% CI 1.58-2.10). Similarly, the corresponding ORs for severe disability were 4.35 (95% CI 3.55-5.34) and 1.78 (95% CI 1.43-2.21). In the age-stratified analysis, in mild disability, the pre-old group (aged 65-74) with frail showed a higher association than the old group (aged ≥ 75) with frail. In severe disability, the old group with frail showed a higher association than the pre-old group with frail. CONCLUSION: The results showed that both prefrail and frail were associated with the incidence of mild and severe disability, and there were different patterns of association between the pre-old/old age groups.

    DOI: 10.4235/agmr.22.0097

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  • Frailty and all-cause and cause-specific mortality in Japan. 国際誌

    Rumi Matsuo, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Archives of gerontology and geriatrics   107   104906 - 104906   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In aging societies, there is an increasing focus on the concept of frailty. However, there is no consistent means to assess this concept. We assessed frailty using the Kihon Checklist (KCL), which is widely used in Japan, and examined the association between frailty and all-cause and cause-specific mortality in Japan, the most aged society in the world. METHODS: This was a retrospective cohort study, and we analyzed 43,312 participants aged ≥ 65 years who were enrolled in basic health checkups in Okayama City, Japan. We defined the frailty status of the participants using the KCL. To assess the association of frailty status with all-cause and cause-specific mortality, we used cause-specific Cox proportional hazard models to estimate hazard ratios (HRs), adjusting for individual potential confounders. Mean follow-up time was 9.3 years. RESULTS: The fully adjusted HR for all-cause mortality was 1.34 (95% confidence interval [CI]: 1.27-1.41) for the prefrail group and 2.22 (95% CI: 2.11-2.33) for the frail group. A similar pattern was observed for cardiovascular disease, respiratory disease, and cancer mortality. Younger people (65-74 years) and women tended to have higher effect estimates than older people (≥ 75 years) and men. CONCLUSION: Prefrailty and frailty can increase the risk of both all-cause and cause-specific mortality. Our study suggests that to support frail patients, it could be effective to focus on the prevention and management of cardiovascular and respiratory disease, and that the KCL may be useful as a method of screening for frailty.

    DOI: 10.1016/j.archger.2022.104906

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  • Association Between Fever and Antibody Titer Trends After a Third Dose of the mRNA-1273 Vaccine

    Naomi Matsumoto, Tomoka Kadowaki, Rumi Matsuo, Ayako Sasaki, Chikara Miyaji, Chigusa Higuchi, Masanori Nakayama, Yasue Sakurada, Hideharu Hagiya, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

    Journal of Epidemiology   32 ( 12 )   567 - 569   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20220210

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  • Do Complementary and Alternative Medicine Users Also Use Conventional Medicine? A Repeated Cross-Sectional Study in Japan from 1995 to 2013 国際誌

    Nobuyoshi Matsuki, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Journal of Integrative and Complementary Medicine   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Mary Ann Liebert Inc  

    Introduction: It is recommended that users of complementary and alternative medicine (CAM) also seek conventional medical care to prevent the loss of access to appropriate medical care. However, the status of such use is unknown. The aim of this study was to examine the time trends in the proportion of CAM users who also receive conventional medical care for the same symptoms. Methods: This is a repeated cross-sectional study. Of data for 753,978 respondents to the Comprehensive Survey of Living Conditions, which was conducted seven times between 1995 and 2013, data from 17,707 individuals who used acupuncture, moxibustion, anma-massage-shiatsu, or judo therapy were analyzed. Cross-classified multilevel logistic regression models with individuals as level 1 and survey year and cohort as level 2 were used to calculate odds ratios (ORs) and 95% credible intervals (CIs) for combined use of CAM and conventional medical care. Age was entered as an individual-level variable. The period effect after 2003 was entered as a survey year-level variable because the number of eligible persons providing CAM treatments has increased since 2003. Results: Among the 17,707 CAM users, 11,567 (65.3%) were women. When age was entered as an explanatory variable, the results showed that both older men and women tended to receive conventional medical care (women, OR: 1.04, 95% CI: 1.03-1.04; men, OR: 1.03, 95% CI: 1.02-1.04). Additional examination of the possible period effect after 2003 showed a positive (although nonsignificant) association (women, OR: 1.36, 95% CI: 0.89-1.99; men, OR: 1.37, 95% CI: 0.94-1.91). Conclusions: As patient age increased, patients combined CAM use with conventional medicine. The findings also suggested that the combined use of CAM and conventional medicine has increased since 2003.

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  • Timing of REGEN-COV administration and progression to severe COVID-19 国際誌

    Tomoka Kadowaki, Sato Imajou, Naomi Matsumoto, Soshi Takao, Takashi Yorifuji

    Journal of Infection and Chemotherapy   28 ( 11 )   1459 - 1463   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    INTRODUCTION: Several clinical trials have demonstrated that REGEN-COV (casirivimab and imdevimab) decreases the risk of hospitalization and death among COVID-19 patients. However, these trials did not evaluate the optimal timing of its administration, and evidence is limited regarding the relationship between the timing of administration and progression to severe COVID-19 among patients who receive REGEN-COV in a real-world setting. We examined the association between the timing of REGEN-COV administration and progression to severe COVID-19 among patients who received REGEN-COV in Japan. METHODS: We included a total of 342 COVID-19 patients (37 hospitals) who received REGEN-COV between July 19 and September 30, 2021. We calculated the difference between the date of symptom onset and the date of administration as an indicator of the timing of REGEN-COV administration and determined progression to severe COVID-19 after REGEN-COV administration. We conducted a logistic regression analysis, adjusting for potential confounders. RESULTS: The proportion of cases progressing to severe COVID-19 increased daily from symptom onset and sharply increased from day 5 of onset. The early administration (days 0-4) decreased the risk of progression to severity compared with late administration (after day 5), with an adjusted odds ratio of 0.29 (95% confidence interval: 0.11-0.56). CONCLUSIONS: The early administration of REGEN-COV was associated with a decreased risk of progression to severe COVID-19 when the delta variant was dominant. The present epidemiological findings indicate that this monoclonal antibody therapy should be implemented very early in the clinical course probably even for emerging variants such as omicron BA.2.

    DOI: 10.1016/j.jiac.2022.07.002

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  • The validity of atypical psychosis diagnostic criteria to detect anti-NMDA receptor encephalitis with psychiatric symptoms 国際誌

    Kenji Hinotsu, Chikara Miyaji, Yuji Yada, Hiroki Kawai, Shinji Sakamoto, Yuko Okahisa, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Soshi Takao, Yoshiki Kishi, Manabu Takaki, Norihito Yamada

    Schizophrenia Research   248   292 - 299   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    Anti-NMDAR encephalitis has a psychotic presentation that is difficult to distinguish from primary psychosis. An atypical psychosis that is similar to schizophrenia, mood disorder, and epilepsy is unique, and the original diagnostic criteria exist only in Japan. The clinical symptoms and courses of anti-NMDAR encephalitis and atypical psychosis are very similar. We investigated whether the diagnostic criteria of atypical psychosis are useful to increase the detection rate of anti-NMDAR encephalitis with psychiatric symptoms. The presence of anti-NR1/NR2B IgG antibodies in the cerebrospinal fluid of 218 newly admitted inpatients initially diagnosed with schizophrenia (n = 151), mood disorder (n = 47), or epilepsy with psychiatric symptoms (n = 20) was assessed by cell-based assay. Of 218 patients, 123 (36.3 years ± SD 17.2, 69.9 % females) fulfilled the diagnostic criteria of category B for atypical psychosis. All 12 patients (9.8 %, 12/123) with anti-NR1/NR2B IgG antibodies fulfilled category B of atypical psychosis statistically better than the patients without anti-NR1/NR2B IgG antibodies (P = 0.0009). Of the 12 patients with anti-NMDAR antibodies, two did not fulfill either criteria of catatonia (DSM-5) or Graus' diagnostic criteria of anti-NMDAR encephalitis during the time course, and 11 patients showed good prognosis with early immunotherapies. In ROC analysis, abnormal electroencephalogram findings showed the highest sensitivity (0.833) for detection of anti-NR1/NR2B IgG antibodies, and 31.3 % of patients with category B atypical psychosis and abnormal electroencephalogram findings had anti-NMDAR antibodies. Lumbar puncture and detection of anti-NMDAR antibodies should be considered for patients who fulfill atypical psychosis diagnosis criteria with an abnormal electroencephalogram.

    DOI: 10.1016/j.schres.2022.08.024

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  • フレイルと障害程度別の要介護認定との関連について 3年間のコホート研究

    萩山 明和, 高尾 総司, 頼藤 貴志, 濱田 全紀, 堅山 佳美, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S480 - S480   2022年10月

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    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

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  • A Simple and Descriptive Assessment of Morphology Based on the Horizontal Plane of the Pediatric Head and Creation of a Normative Database in Japanese Children 6 Years Old and under: Horizontal Vector Analysis.

    Sho Komagoe, Takaya Senoo, Soshi Takao, Yoshinori Shiraishi, Hiroshi Matsumoto, Yoshihiro Kimata

    Acta medica Okayama   76 ( 5 )   565 - 575   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We herein introduce horizontal vector analysis, a simple method for assessing cranial morphology based on measurement of the head's horizontal plane, and use this method to establish normal cranial morphology in Japanese children Computed tomography scans taken in 2010-2019 in healthy Japanese children aged ≤ 6 years. The two measurement planes were parallel to the orbitomeatal plane: namely, a plane passing through the dorsum sellae (DS) and the plane superior to that with the maximal area (Max plane). A protractor was used to circumferentially measure the lengths from the central point to the outer surface of the skull. A total of 487 images were extracted. The distances between the DS and Max planes were consistently almost 30 mm for each age group, so we fixed the Max plane as the plane 30 mm superior to the DS plane. Finally, we established datasets of normal values for each age group and sex. Using these norms, perioperative evaluation of various cranial deformities could be performed more easily and circumstantially.

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  • Examining the association between vaccine reactogenicity and antibody titer dynamics after the third dose of BNT162b2 vaccine using a mixed-effects model 国際誌

    Naomi Matsumoto, Hideharu Hagiya, Masanori Nakayama, Masanori Furukawa, Toshiharu Mitsuhashi, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

    Journal of Infection and Chemotherapy   29 ( 1 )   39 - 42   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    BACKGROUND: To mitigate the COVID-19 pandemic, many countries have recommended the use of booster vaccinations. The relationship between the degree of adverse vaccine reactions and elevated antibody titers is of interest; however, no studies have investigated the temporal changes in antibody titers based on repeated measurements after a third dose of the BNT162b2 vaccine. METHODS: This prospective longitudinal cohort study was conducted with 62 healthcare workers who received a third dose of the BNT162b2 at Okayama University Hospital, Japan. Venous blood draw and fingertip whole blood test sample collection were conducted at the early (3-13 days) and 1-month time points; only FWT sample collection was conducted at the 2-month time point. Information on adverse reactions within 1 week after vaccination was also obtained. The association between fever of 37.5 °C or higher and antibody titers after the third dose of BNT162b2 was examined using a mixed-effects model and Poisson regression with robust variance. RESULTS: A trend toward higher antibody titers in the early period after vaccination was observed in the febrile individuals, but the differences were not significant at 1 and 2 months post-vaccination (the partial regression coefficient for fever was 8094.3 [-1910.2, 18,098.8] at 1 month after vaccination, and 1764.1 [-4133.9, 7662.1] at 2 months after vaccination in the adjusted models). CONCLUSION: The findings suggest that the presence of fever after the third vaccine does not predict a sustained elevation in serum antibody titers.

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  • Social Capital and Post-traumatic Stress Disorder among Heavy Rainfall and Flood Victims in Japan.

    Chikara Miyaji, Soshi Takao, Masayuki Noguchi, Tsubasa Okazaki, Shunsuke Sato, Takashi Yorifuji

    Acta medica Okayama   76 ( 4 )   439 - 446   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex.

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  • Effects of Tanden Breathing on Constipation: A Randomized Controlled Trial.

    Hiroshi Habu, Toshiharu Mitsuhashi, Akiko Tokinobu, Takashi Yorifuji, Soshi Takao

    Acta medica Okayama   76 ( 4 )   391 - 398   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Tanden breathing, an ancient health technique, involves expiratory abdominal pressure breathing is practiced in Japan. In this study we examined the ability of Tanden breathing to relieve constipation. The study was designed as a stratified-block randomized controlled trial enrolling 20 participants. Nineteen were female and one was male, none were elderly. During the 6-week intervention period, the participants performed video-guided Tanden breathing about 10 min once day. We evaluated constipation using the Constipation Assessment Scale (CAS). There were significant differences in the mean CAS score between time points (baseline, 3 weeks after baseline, 6 weeks after baseline), groups (intervention and control), and their interaction (time×group) using repeated-measures analysis of variance. The control group showed no change in the mean CAS score; the mean CAS scores of the intervention group changed from 7.2 at baseline to 3.9 at 3 weeks and 3.1 at 6 weeks after baseline. A regression analysis of the difference in the mean CAS between baseline and 6 weeks later showed that the CAS of the intervention group was 4.3 points lower than that of the control group (95% confidence interval, 2.5-6.1). The results suggested that Tanden breathing is effective in relieving constipation among young women.

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  • アルコール依存症に対するナルメフェンの無作為化比較試験における臨床的モデレーターについて 探索的分析

    橋本 望, 土生 裕, 高尾 総司, 酒本 真次, 岡久 祐子, 松尾 恵太郎, 高木 学, 来住 由樹, 山田 了士

    日本アルコール・薬物医学会雑誌   57 ( 4 )   239 - 239   2022年8月

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    記述言語:日本語   出版者・発行元:(一社)日本アルコール・アディクション医学会  

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  • Candidemia in patients with head and neck cancer: mortality and a novel risk factor. 国際誌

    Kensuke Uraguchi, Takuma Makino, Shin Kariya, Youhei Noda, Hidenori Marunaka, Akira Doi, Kenichi Kozakura, Soshi Takao, Mizuo Ando

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer   30 ( 7 )   5921 - 5930   2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    PURPOSE: Candidemia is a bloodstream infection (BSI) by Candida spp. and is associated with high mortality. However, there have been few reports about BSI in head and neck cancer (HNC). We aimed to evaluate the impact of candidemia in patients with HNC and compared it with bacteremia. STUDY DESIGN: A multicenter retrospective study. METHODS: We retrospectively analyzed 83 BSI episodes in HNC (2011 to 2020) and divided them into the candidemia and bacteremia groups. We then compared the survival rate and risk factors for candidemia between the groups. RESULTS: The overall cumulative incidence (risk) of candidemia in BSI was 12 out of 83 episodes (14.5%). The 1-year mortality for the bacteremia and candidemia groups was 33.3% and 58.3%, respectively (log-rank p = 0.041). Broad-spectrum antibiotics (odds ratio [OR]: 29.5; 95% confidence interval [CI], 2.49-350), mucositis (OR 11.0; 95% CI, 1.52-80.1), and malignant wounds (OR 79.5; 95% CI 1.33-4737) were significant risk factors for candidemia in HNC. CONCLUSIONS: Candidemia causes high mortality in patients with HNC. To our knowledge, malignant wounds have not been previously reported as a risk factor for candidemia. For early diagnosis and treatment of candidemia, risk factors should be considered, and antifungal therapy started earlier.

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  • Relationship between spontaneous nystagmus and video Head Impulse Test findings among patients with chronic neurotologic conditions. 国際誌

    Yukihide Maeda, Soshi Takao, Iku Abe-Fujisawa, Shin Kariya, Mizuo Ando

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   99   244 - 247   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The vestibulo-ocular reflex (VOR) in neurotologic patients can be evaluated most quickly by spontaneous nystagmus examinations, and the video Head Impulse Test (vHIT) quantitatively evaluates the VOR of the semicircular canals. We aimed to clarify the concordance and discrepancies between spontaneous nystagmus and vHIT findings, to provide guidance on screening vestibular functions by initial spontaneous nystagmus examination then vHIT. We evaluated 169 outpatients by spontaneous nystagmus examination in the dark using a charge-coupled device camera, then by horizontal vHIT the same day. Vestibular loss on vHIT was defined if both reduced VOR gain (<0.8) and corrective saccade were observed. Adjusted logistic regression modelling revealed that differences in right and left VOR gain positively impacted the presence of nystagmus, which suggests lateralised vestibular dysfunction (P<0.05; odds ratio 1.39 [95% confidence interval, 1.1-1.8] per 0.1 increment). When vHIT is regarded as the standard clinical test, the positive predictive value of nystagmus for vestibular loss on vHIT was 44.4%, and the negative predictive value was 93.5%. The adjusted odds ratio of adults ≥65 years old compared to younger patients associated with a discrepancy of nystagmus and vHIT was significant (2.4 [1.1-5.3]). In conclusion, if spontaneous nystagmus is initially observed in patients, further assessment by vHIT could confirm vestibular dysfunction in 40-50% of cases. If no nystagmus is observed, vHIT might also result in a negative finding in >90% of cases. Older adults appear more likely to show discrepancies between nystagmus and vHIT.

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  • Adverse reactions and attitudes toward vaccines among young populations one month after receiving a second dose of mRNA-1273 in Japan

    Naomi Matsumoto, Chigusa Higuchi, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

    Global Health &amp; Medicine   4 ( 2 )   141 - 143   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:National Center for Global Health and Medicine (JST)  

    To investigate adverse reactions and attitudes toward the vaccine during the first month after mRNA- 1273 vaccination in a larger sample including younger men and women in Japan, we distributed a 1-month post-vaccination questionnaire using a Google form to 8,566 people who received a second dose of mRNA-1273 at Okayama University. The response rate was about 40.2% (3,447 responses), the sex ratio was about the same, and 73.3 % (2,528 respondents) were students in their twenties or younger. Poisson regression with robust variance was performed to calculate the prevalence ratio of each symptom by different attributes. The most common adverse reactions after the second vaccine dose were local pain (80.4%), fever (85.1%), malaise (82.0%), headache (64.0%), and chills (57.4%). Approximately 99% of respondents reported that their adverse reactions resolved within 1 week. Over 80% of respondents were satisfied with their vaccination (87.2%), expressed interest in receiving the third vaccination (83.3%), and would recommend vaccination to their loved ones (80.2%). However, among them, 22.0% (757 respondents) would recommend and 28.4% (980 respondents) also stated that they would consider the type of vaccine in these decisions.

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  • Clinical moderators of response to nalmefene in a randomized-controlled trial for alcohol dependence: An exploratory analysis. 国際誌

    Nozomu Hashimoto, Hiroshi Habu, Soshi Takao, Shinji Sakamoto, Yuko Okahisa, Keitaro Matsuo, Manabu Takaki, Yoshiki Kishi, Norihito Yamada

    Drug and alcohol dependence   233   109365 - 109365   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Nalmefene is the only medication marketed to reduce the consumption of alcohol in patients with alcohol dependence, but it remains unclear which patients could most benefit from it. This study aimed to identify clinical moderators that affect treatment response to nalmefene in patients with alcohol dependence. METHODS: In a multicenter, randomized, controlled, double-blind, phase 3 study of nalmefene on Japanese patients with alcohol dependence, the relationship between the reduction of heavy drinking days (HDD) and total alcohol consumption (TAC) at 12 and 24 weeks of treatment and baseline variables of the participants were analyzed in a linear regression and multiple adjusted analysis. RESULTS: Age < 65, no family history of problem drinking, age at onset of problem drinking ≥ 25, and not currently smoking were possible positive moderators. Nalmefene showed a significant HDD reduction in patients with age < 65 or no family history of problem drinking, and a significant TAC reduction in patients with age at onset of problem drinking ≥ 25 or who were not currently smoking. After multiple adjusted analyses, age < 65 (p = .028), no family history of problem drinking (p = .047), and age at onset of problem drinking ≥ 25 (p = .030) were statistically significant. Not currently smoking (p = .071) was marginally significant. In combination, these moderators indicated synergistic effects. CONCLUSIONS: Alcohol-dependent patients with favorable prognostic factors such as non-smoking status, no family history of problem drinking, and a late-onset of problem drinking selectively benefit from nalmefene. Further research is needed to validate these exploratory results.

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  • Effect of mRNA Vaccines in Preventing COVID-19 Severe Pneumonia Among COVID-19 Patients in Japan

    Rumi Matsuo, Naomi Matsumoto, Tomoka Kadowaki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

    Journal of Epidemiology   32 ( 3 )   151 - 152   2022年3月

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    記述言語:英語   出版者・発行元:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20210487

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  • Association between depression in chronic phase and future clinical outcome of patients with schizophrenia. 国際誌

    Yuto Yamada, Yusuke Yamauchi, Shinji Sakamoto, Masaki Fujiwara, Yuko Okahisa, Soshi Takao, Manabu Takaki, Norihito Yamada

    Psychopharmacology   239 ( 3 )   965 - 975   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    RATIONALE: Depression in schizophrenia is an important symptom. We investigated whether depression and suicidal symptoms in the chronic phase are related to remote future clinical outcomes in patients with schizophrenia and whether psychotropics improved clinical outcomes. OBJECTIVES: The subjects included 462 outpatients of working age (15 to 64 years old) with schizophrenia treated at Okayama University Hospital from January 2010 to December 2011. We investigated the relationship between the Clinical Global Impression-Severity score at the last visit (average 19.2 years) and the existence of previous depression, suicidal ideas, and suicide attempts. We adjusted by several possible confounders including medical history using multiple regression analysis or logistic regression analysis. RESULTS: Of 462 patients, 168 (36.4%) presented with depression 2 years after schizophrenia onset. A history of suicidal ideas and attempts was related to worse clinical outcome. In males, a history of depression was related to worse clinical outcome, but not in females. Lithium carbonate was related to better clinical outcome in all schizophrenia patients with depression, especially in males. Treatment with antidepressants was related to better clinical outcome only in males. CONCLUSIONS: A history of depression or suicidal symptoms in the chronic phase predicted the future worse clinical outcome in patients with schizophrenia. The administration of lithium carbonate or antidepressants might be recommended, especially to male schizophrenia patients with depression.

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  • Reusable Medical Isolation Gowns with a Liquid Barrier: Washing Gowns in the Coronavirus Disease 2019 Pandemic Era?

    Hiromichi Naito, Kohei Tsukahara, Soshi Takao, Takashi Yorifuji, Atsunori Nakao

    JMA journal   5 ( 1 )   107 - 108   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Healthcare providers are at risk of exposure to SARS-CoV-2 via droplets, respiratory secretions, and contact with contaminated surfaces. Personal protective equipment (PPE) is necessary for primary reliable prevention to treat patients with coronavirus disease 2019 (COVID-19). However, PPE shortages have had a significant impact on every medical facility, and outpatient clinics are especially vulnerable to shortages of medical supplies. During the first stage of the pandemic, efforts were made to reduce the use of medical supplies. Guidance and strategies were proposed to ration the use of PPE, including reusing it. However, reuse (wash) of isolation gowns has not been practically promoted despite these suggestions. Further, reusable products may have advantages for economic and ecologic reasons. We developed an adult universally sized, long-sleeved, 100% polyester, reusable/washable gown with liquid barrier protection. The isolation gown can be worn repeatedly through washing and subsequent disinfection, and it can withstand washing in 80°C hot water for 10 min and/or immersion in 0.05%-0.1% sodium hypochlorite for 30 min and then dried. This new gown's liquid barrier performance is at Association for the Advancement of Medical Instrumentation level 1, even after 20 repeated uses with low cost. The choice of barrier level for gowns should be made based on the risk of contamination. However, the healthcare setting for COVID-19 patients varies greatly with not fully elucidated transmissibility. The newly made reusable isolation gown can be one option for treating COVID-19 patients especially in low-risk settings with economical advantage. Further, preparedness for reuse may have critical implications in extreme shortage. Reconsideration should be focused on reusable gowns with liquid barrier performance and their appropriate use.

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  • Association of nighttime sleep with behaviors in Japanese early childhood 国際誌

    Yusuke Yamauchi, Soshi Takao, Naomi Matsumoto, Takashi Yorifuji

    Pediatrics International   64 ( 1 )   e15354   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    BACKGROUND: Preschool children in Asian countries, including Japan, sleep for a shorter duration at night than those in Europe and the USA. We examined the effects of the nighttime sleep duration on behavioral development in early childhood in Japan. METHODS: We used data from a large Japanese nationwide, population-based, longitudinal survey that began in 2001. We restricted the study participants to children born after 37 gestational weeks, with a birth weight ≥ 2500 g and singleton births (n = 41 890). The nighttime sleep duration was examined at 2.5 years old. Responses to survey questions regarding age-appropriate behavior at 5.5 years old were used as indicators of behavioral development. We conducted logistic regression analyses with adjustment for confounding factors, with ≥11 h of nighttime sleep as the reference group. RESULTS: The odds ratios for children who had ≤9 h of nighttime sleep, which was associated with being unable to listen with fidgeting and being unable to remain patient, were 1.26 (95% confidence interval, 1.14-1.39) and 1.27 (1.16-1.38), respectively. Children who had an irregular nighttime sleep duration were associated with age-appropriate behavioral inabilities. These results were similar in children who usually and sometimes took naps to those before stratification by the frequency of napping. CONCLUSION: A short nighttime sleep duration especially affects hyperactivity and impulsivity. An irregular nighttime sleep duration increases the inability to perform overall age-appropriate behaviors more than a short sleep duration. Ensuring a regular and sufficient nighttime sleep duration in early childhood is important for healthy behavioral development.

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  • Static posturographic balance in neurotologic patients may be associated with middle-high-frequency hearing levels during ageing process. 国際誌

    Yukihide Maeda, Soshi Takao, Iku Abe-Fujisawa, Shin Kariya, Mizuo Ando

    Acta oto-laryngologica   142 ( 3-4 )   280 - 284   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Understanding how sensorineural hearing loss (SNHL) impacts postural balance in patients is important, as postural balance predicts the risk of falls. AIMS/OBJECTIVES: We aimed to clarify the relationship between characteristics in the configuration of audiograms and static postural balance as measured by posturography. MATERIALS AND METHODS: We evaluated 385 outpatients (mean [± standard deviation] age, 58.4 ± 18.4 years) with SNHL by audiometry and posturography. Data were analysed by multiple regression models with the outcome of postural sway area with eyes closed (PSA) and predictive variables of audiometric data, adjusted for sex, age and the presence of nystagmus. RESULTS: The increased hearing threshold in the better hearing ear was associated with poorer or higher PSA (beta coefficient [β] = 0.39, 95% confidence interval [CI] = 0.03-0.75, per 10-dB increment). No difference in PSA was detected between patients with asymmetric or symmetric SNHL. None of the frequent diagnoses (presbyacusis, Meniere's disease, and idiopathic sudden SNHL) were associated with poorer PSA. Hearing thresholds at middle (β = 0.39, 95%CI = 0.10-0.67) and high frequencies (β = 0.31, 95%CI = 0.07-0.55) were associated with poorer PSA, whereas those at low frequencies was not. CONCLUSIONS AND SIGNIFICANCE: Postural balance in neurotologic patients may be associated with middle-high-frequency hearing levels during ageing.

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  • Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis

    Sojiro Okamoto, Manabu Takaki, Kenji Hinotsu, Hiroki Kawai, Shinji Sakamoto, Yuko Okahisa, Soshi Takao, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Norihito Yamada

    PSYCHOPHARMACOLOGY   239 ( 2 )   525 - 531   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Rationale Adequate immunotherapies for anti-NMDAR encephalitis during pregnancy produce a relatively good clinical outcome for pregnant mothers and their infants, but there are no reports about the future growth of their babies. The damage of anti-NMDAR antibodies to early neuronal development is still unknown. Objectives Serum or cerebrospinal fluid from one patient with anti-NMDAR encephalitis (the index patient) and one patient with schizophrenia (the control patient) was administered to primary cultures of dissociated rat cortical neurons, and dendritic outgrowth, centrosome elimination, and branching of dendrites were investigated. For rescue experiments, serum of the index patient was replaced with normal culture media after 3 days' administration of the index patient. Results Serum and cerebrospinal fluid of the index patient statistically significantly impaired dendritic outgrowth of cultured rat cortical primary neurons. Serum of the index patient also statistically significantly delayed centrosome elimination. Impaired dendritic outgrowth and delayed centrosome elimination were not perfectly rescued by changing to normal culture media. Serum of the index patient also statistically significantly reduced the branching of dendrites. Conclusions This is the first demonstration of the damage by anti-NMDAR antibodies on early dendritic development in vitro. As a strategy to protect embryonic neurons, our findings may support the efficacy of early immunotherapy for anti-NMDAR encephalitis in pregnancy.

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  • Emergency Dispatches for Suicide Attempts During the COVID-19 Outbreak in Okayama, Japan: A Descriptive Epidemiological Study.

    Hiroshi Habu, Soshi Takao, Ryohei Fujimoto, Hiromichi Naito, Atsunori Nakao, Takashi Yorifuji

    Journal of epidemiology   31 ( 9 )   511 - 517   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hardships associated with the ongoing coronavirus disease 2019 (COVID-19) pandemic can affect mental health, potentially leading to increased risk of suicide. We examined the relationship between the COVID-19 outbreak and suicide attempts in Okayama, Japan using information from emergency dispatches. METHODS: This was a descriptive epidemiological study. We collected information on emergency dispatches in Okayama City and Kibichuo from March to August in 2018, 2019, and 2020 (n = 47,770 cases). We compared emergency dispatches and their demographic characteristics, especially focusing on suicide attempts, during these 3 years. RESULTS: The number of emergency dispatches in 2020 decreased compared with the previous 2 years, while the number and proportion of emergency dispatches related to suicide attempts increased. This increase was more pronounced among women and those aged 25-49 years. Among women aged 25-49 years, there was a cumulative total of 43 suicide attempts in 2018 and 2019 and 73 suicide attempts in 2020. CONCLUSIONS: The number and proportion of emergency dispatches related to suicide attempts increased in 2020 compared with the previous 2 years, especially among women and those aged 25-49 years. This increase may be partly explained by hardships, such as economic losses or reduced social ties, during the COVID-19 outbreak.

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  • Subjective Evaluation of Balance by the Dizziness Handicap Inventory Does Not Predict Fall Risk in Older Adults Visiting Otolaryngology Clinics. 国際誌

    Iku Abe-Fujisawa, Yukihide Maeda, Soshi Takao, Shin Kariya, Kazunori Nishizaki

    The Annals of otology, rhinology, and laryngology   130 ( 9 )   990 - 995   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Subjective symptoms of dizziness in older adults are affected not only by objective data such as postural balance, but also by complex psychological factors. Published data analyzing how simultaneous evaluations of both objective and subjective assessments of balance can predict fall risk remain lacking. This study examined how fall risk can be predicted based on both objective data for balance and hearing and subjective symptoms of dizziness among older adults visiting otolaryngology clinics. METHODS: Medical charts of 76 patients ≥65 years old with dizziness/vertigo who visited the otolaryngology clinic were reviewed. Objective data were evaluated by postural balance (posturographic data with eyes open and closed, and one-leg standing test), spontaneous nystagmus, and mean hearing levels. Subjective handicap associated with dizziness/vertigo was assessed using the Dizziness Handicap Inventory (DHI). Subjective mental status of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Information on history (cardiovascular diseases) and fall accidents within the preceding year was collected using an in-house interview sheet. RESULTS: Objective data on postural balance did not correlate with subjective symptoms on DHI or HADS (P > .05, Pearson's correlation coefficient). Adjusted logistic regression modeling with the outcome of incident falls revealed that poor postural balance significantly predicted fall risk (P < .05; 4.9 [1.4-16.8] per 10-cm2 increment). Nystagmus tended to be associated with fall risk. In contrast, DHI score did not predict fall risk (P = .43; 1.0 [0.9-1.03]). Receiver operating characteristic analysis proposed a cut-off for postural sway with eyes closed >6.1 cm2 as optimal to predict falls in patients with nystagmus (AUC, 0.74; 95% confidence interval, 0.48-0.997). CONCLUSION: Poor postural balance is associated with increased fall risk after adjusting for subjective symptoms in older adults at otolaryngology clinics. Conversely, the self-perceived dizziness handicap of DHI score is an insufficient tool to evaluate their fall risk.

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  • Percutaneous Cryoablation of Lower Limb Soft-Tissue Venous Malformations: Preliminary Results of Long-Term Efficacy. 国際誌

    Hiroyasu Fujiwara, Takao Hiraki, Yusuke Matsui, Mayu Uka, Koji Tomita, Toshihiro Iguchi, Jun Sakurai, Takao Soshi, Hideo Gobara, Susumu Kanazawa

    Cardiovascular and interventional radiology   44 ( 9 )   1485 - 1490   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To retrospectively evaluate long-term efficacy of percutaneous cryoablation for lower limb soft-tissue venous malformations. MATERIALS AND METHODS: Nine patients (mean age, 36.6 years) with lower limb soft-tissue venous malformations were included. Cryoablation was performed percutaneously using an argon-based system. Adverse events (AE) using the Common Terminology Criteria for AEs version 4.0 were evaluated. The visual analog scale (VAS) scores and lesion volumes measured on magnetic resonance imaging were also evaluated at 12 months and 5-6 years. RESULTS: Technical success (i.e., complete coverage of the lesion by an iceball) was achieved in eight of the nine patients. All patients developed a total of 14 grade 1 or 2 adverse events. The mean (± standard deviation) VAS score was 6.0 (± 1.7) before therapy, whereas it was 0.14 (± 0.27) at 12 months and 0.97 (± 1.3) at 5-6 years (58-78 months). Complete pain relief was obtained in 6 and 5 patients at 12 months and 5-6 years, respectively. The median lesion volume was 2.49 mL before therapy, whereas it was 0.26 mL at 12 months and 0.35 mL at 5-6 years. CONCLUSION: Percutaneous cryoablation of lower limb soft-tissue venous malformations achieved considerable pain relief and lesion shrinkage for 5-6 years in this small preliminary study. LEVEL OF EVIDENCE: Level 4, Case Series.

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  • PD-L1 expression in tongue squamous cell carcinoma.

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   52 - 59   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This large-scale case study aimed to analyze tongue squamous cell carcinomas (SCCs) and evaluate the correlation between PD-L1 expression and clinical prognosis. So far, this study is the largest case study on PD-L1 expression in tongue SCCs. METHODS: This is a case-control study that analyzed 121 tongue SCCs. Paraffin-embedded sections and clinical data were obtained retrospectively and immunohistochemistry with PD-L1 was performed. RESULTS: 11.6% contained ≥ 50% of PD-L1-positive cells, 57.1% of these cases had a poor prognosis with nodal metastasis. Among cases of T1/2 primary lesions with nodal metastasis, cases of high PD-L1 expression had a significantly shorter disease-free survival than cases of no PD-L1 expression (p = 0.018). The hazard ratio for high PD-L1 expression was 3.21 (95 per cent CI, 1.26-8.72) compared with no PD-L1 expression after adjusting for other factors. CONCLUSIONS: These data indicate that PD-L1 upregulation in tongue SCCs is associated with a more advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors might hence constitute potential adjuvant therapy for tongue SCCs with PD-L1 upregulation.

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  • Correction to: PD-L1 expression in tongue squamous cell carcinoma.

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   68 - 68   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In the original publication of the article an affiliation should be added to the first author “Naoki Akisada” as given below:5Departments of Otolaryngology Head and Neck Surgery,Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama 700‑8558,Japan

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  • クロザピン血中濃度と効果や副作用の関連について:多施設横断研究 国際誌

    矢田勇慈, 矢田勇慈, 北川航平, 酒本真次, 小澤篤嗣, 仲田明弘, 柏木宏子, 岡久祐子, 高尾総司, 高木学, 来住由樹, 山田了士

    日本臨床精神神経薬理学会プログラム・抄録集   143 ( 3 )   227 - 237   2021年3月

  • The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study. 国際誌

    Yuji Yada, Kohei Kitagawa, Shinji Sakamoto, Atsushi Ozawa, Akihiro Nakada, Hiroko Kashiwagi, Yuko Okahisa, Soshi Takao, Manabu Takaki, Yoshiki Kishi, Norihito Yamada

    Acta psychiatrica Scandinavica   143 ( 3 )   227 - 237   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    OBJECTIVE: There is no report that statistically evaluates the therapeutic reference (350-600 ng/ml) and adverse drug reaction (ADR) range (>1000 ng/ml) of clozapine (CLZ) recommended by the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) consensus guidelines in an isolated and large sampling study. METHODS: We administered CLZ to 131 Japanese patients with treatment-resistant schizophrenia in a multicenter cross-sectional study. Plasma CLZ concentrations were assayed by high-performance liquid chromatography using trough sampling. The Brief Psychiatric Rating Scale (BPRS) and severe dose-dependent ADR (sedation, myoclonus, and seizures) were analyzed statistically after adjusting for possible confounders. RESULTS: The daily CLZ dosage showed a moderately positive relationship with the plasma concentration (r = 0.49, p < 0.001). Every 100 ng/ml increase in plasma CLZ concentration improved the total BPRS score 1.95% (95% CI: 0.89-3.01, p < 0.001) and the odds ratio (OR) 1.38 (95% CI: 1.14-1.66, p = 0.001) for BPRS response. Compared with concentrations below 350 ng/ml CLZ, 350-600 ng/ml (11.12%; 95% CI: 2.52-19.72, p = 0.012) and 600-1000 ng/ml (11.05%; 95% CI: 2.40-19.71, p = 0.013) showed significant improvement in the total BPRS score. Dosages above 1000 ng/ml showed greater improvement (25.36%; 95% CI: 13.08-37.64, p < 0.001) of the total BPRS score but more severe ADRs than dosages below 1000 ng/ml (OR: 31.72; 95% CI: 1.04-968.81, p = 0.048). CONCLUSION: The AGNP therapeutic reference range (350-600 ng/ml) is useful, and a dose above 1000 ng/ml is potentially more effective but carries the risk of severe ADRs in the central nervous system.

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  • Excess All-Cause Mortality During the COVID-19 Outbreak in Japan.

    Takashi Yorifuji, Naomi Matsumoto, Soshi Takao

    Journal of epidemiology   31 ( 1 )   90 - 92   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    DOI: 10.2188/jea.JE20200492

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  • Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis. 査読 国際誌

    Aiko Oka, Takahiro Ninomiya, Tazuko Fujiwara, Soshi Takao, Yasuharu Sato, Yuka Gion, Akira Minoura, Shin-Ichi Haruna, Naohiro Yoshida, Yasunori Sakuma, Kenji Izuhara, Junya Ono, Masami Taniguchi, Takenori Haruna, Takaya Higaki, Shin Kariya, Takahisa Koyama, Tetsuji Takabayashi, Yoshimasa Imoto, Masafumi Sakashita, Masanori Kidoguchi, Kazunori Nishizaki, Shigeharu Fujieda, Mitsuhiro Okano

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 3 )   417 - 423   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS. METHODS: Association between the serum IgG4 levels and clinicopathological factors was analyzed in 336 CRS patients. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of serum IgG4 levels that can be used to predict the post-operative recurrence. RESULTS: Serum IgG4 levels were significantly higher in patients with moderate to severe ECRS versus those with non to mild ECRS. The levels were also significantly higher in asthmatic patients and patients exhibiting recurrence after surgery compared to controls. ROC analysis determined that the best cut-off value for the serum IgG4 level to predict the post-operative recurrence was 95 mg/dL. The corresponding sensitivity and specificity were 39.7% and 80.5%, respectively. When we combined the two cut-off values for the serum IgG4 and periostin, patients with high serum levels of either IgG4 or periostin exhibited a high post-operative recurrence (OR: 3.95) as compared to patients having low serum levels of both IgG4 and periostin. CONCLUSIONS: The present results demonstrate that the serum IgG4 level is associated with disease severity and post-operative course in CRS. In particular, the combination of serum IgG4 and periostin could be a novel biomarker that predicts post-operative recurrence.

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  • MACC1 expression is an indicator of recurrence in early-stage glottic cancer 国際誌

    Takuma Makino, Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Soshi Takao, Hidenori Marunaka, Kentaro Miki, Naoki Akisada, Yusuke Akagi, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Japanese Journal of Clinical Oncology   50 ( 4 )   392 - 398   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer. Methods Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n = 52) were immunohistochemically analyzed to explore MACC1 expression. The clinical records associated with each case were also examined. Recurrence-free survival (RFS) was estimated using the Kaplan- Meier method, and between-group RFS differences were assessed using the log-rank test. The multivariate analyses were evaluated using the Cox's proportional-hazard model. Results Patients were treated with only radiotherapy (RT) (n = 37, including 18 with T1 disease and 19 with T2 disease), or with chemoradiotherapy (CRT) (n = 15, including 1 with T1 disease and 14 with T2 disease). Eleven patients demonstrated local recurrence and two patients experienced cervical lymph node recurrence. Tumor specimens were MACC1-positive in 9 of the 13 (69.2%) patients with local or neck recurrence, and 7 of the 11 (63.6%) patients with local recurrence. The RFS rate of patients who were treated with only RT was significantly lower than that of patients who were treated with CRT (P = 0.0243). The RFS rate was significantly lower in cases with MACC1 expression than in those without MACC1 expression (P = 0.0003). Multivariate analysis revealed that MACC1 expression was an independent risk factor of local recurrence (P = 0.0016). Conclusion MACC1 is an independent indicator of recurrence related to RFS in early-stage glottic cancer.

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  • Switching strategies for antipsychotic monotherapy in schizophrenia: a multi-center cohort study of aripiprazole

    Yoshiaki Obayashi, Satoshi Mitsui, Shinji Sakamoto, Nozomu Minao, Bunta Yoshimura, Toshiki Kono, Yuji Yada, Yuko Okahisa, Soshi Takao, Yoshiki Kishi, Toshihiko Takeda, Manabu Takaki, Norihito Yamada

    PSYCHOPHARMACOLOGY   237 ( 1 )   167 - 175   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Rationale Changing antipsychotics of patients with chronic schizophrenia involves several risks. Switching to aripiprazole is especially difficult. We investigated switching methods and related factors for successful switching patients with chronic schizophrenia to aripiprazole. Objectives This study was a multi-center historical cohort study and approved by the research ethics committee of Okayama University Hospital and Okayama Psychiatric Medical Center. We compared survival proportions of 178 chronic schizophrenia patients who continued aripiprazole monotherapy for 6 months after non-direct switching (add-on switching (n = 45), cross switching (n = 62)) or direct switching (n = 71). We adjusted possible confounders using a Cox proportional hazards model. Results Of patients with chronic schizophrenia, 56.7% (101/178) were switched to aripiprazole monotherapy, and 55.0% (98/178) showed improvement in symptoms as demonstrated by the Clinical Global Impression Severity score. Kaplan-Meier survival curves showed that non-direct switching had a higher survival proportion than direct switching (log-rank test, p = 0.012). Even after adjusting for several variables using a Cox proportional hazards model, add-on switching had a significantly lower hazard at 6 months than direct switching (hazard ratio 0.42, 95% confidence interval 0.21-0.82, P = 0.01). In cases of switching to aripiprazole for psychiatric symptoms, non-direct switching had a lower hazard than direct switching (hazard ratio 0.41, 95% confidence interval 0.21-0.81, P = 0.01) but was not significant for adverse reaction. When aripiprazole was switched from olanzapine, add-on switch showed the lowest hazard ratio for continuation (hazard ratio 0.29, 95% confidence interval 0.07-1.11, P = 0.07). Conclusions Flexibility in strategies when switching to aripiprazole may induce a better outcome for patients with chronic schizophrenia.

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  • 統合失調症患者におけるアリピプラゾール単剤治療への切替方法についての検討(多施設コホート研究) 国際誌

    大林芳明, 大林芳明, 大林芳明, 大林芳明, 光井聡, 酒本真次, 皆尾望, 吉村文太, 耕野敏樹, 矢田勇慈, 岡久祐子, 高尾総司, 来住由樹, 武田俊彦, 高木学, 山田了士

    日本臨床精神神経薬理学会プログラム・抄録集   237 ( 1 )   167 - 175   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00213-019-05352-7

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  • Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. 国際誌

    Akiko Sugaya, Kunihiro Fukushima, Soshi Takao, Norio Kasai, Yukihide Maeda, Akie Fujiyoshi, Yuko Kataoka, Shin Kariya, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   126   109619 - 109619   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Reading and writing skills are important for hearing-impaired children since these skills help them to develop their language skills, but the prevalence of reading/writing difficulties and its effects on language development aspects among them are unclear. In this study, we identified language development features and demographic factors of Japanese hearing-impaired children diagnosed as having reading/writing difficulties. METHODS: We analyzed data from a total of 546 sever-to-profound pre-school and elementary school hearing-impaired children for this study. Children with reading/writing difficulties (Group A) were defined as children obtaining low scores (-1.5 SD compared to others in the same grade) in the Screening Test of Reading and Writing for Japanese Primary School Children (STRAW), and we compared other language development features (communication ability, vocabulary, syntax and academic achievement) and demographic factors to those of hearing-impaired children with normal reading and writing skills (Group B). We assessed language development domains as outcomes using the Assessment of Language Development for Japanese Children (ALADJIN) package, and analyzed the results stratified by age groups (5-6, 7-8, 9-10, and 11-12 years) using multiple regression analyses. RESULTS: The prevalence of reading/writing difficulties was 20.1% among the participants. Almost all point estimates in each language development domain showed better odds ratios (OR) except Criterion Referenced Test -II (CRT-II) mathematics in 11- to 12-year-olds in fully-adjusted models. Among 9- to 10-year-olds, the ORs (95% confidence interval) for fair academic achievement measured by CRT-II were 2.60 (1.09-6.20) for Japanese and 3.02 (1.29-7.11) for mathematics in Group B, even after adjusting for possible confounding factors. CONCLUSIONS: Reading and writing are important for language development of hearing-impaired children, especially for academic achievement during the middle phase of elementary school. Screening for reading/writing difficulties is important for appropriate intervention and to prevent language and academic delays among hearing-impaired children.

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  • 初期診断が気分障害であった患者における抗NMDA受容体抗体保有率の検討 査読 国際誌

    河合弘樹, 高木学, 酒本真次, 柴田敬, 土田彩加, 吉村文太, 矢田勇慈, 矢田勇慈, 松本菜見子, 佐藤恒太, 阿部康二, 岡久祐子, 来住由樹, 高尾総司, 筒井幸, 神林崇, 神林崇, 田中恵子, 山田了士

    日本臨床精神神経薬理学会プログラム・抄録集   29 ( 9 )   1041 - 1050   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.euroneuro.2019.07.137

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  • Relationship between workplace social capital and suicidal ideation in the past year among employees in Japan: a cross-sectional study. 国際誌

    Daisuke Hori, Soshi Takao, Ichiro Kawachi, Yuh Ohtaki, Christina-Sylvia Andrea, Tsukasa Takahashi, Nagisa Shiraki, Tomohiko Ikeda, Yu Ikeda, Shotaro Doki, Yuichi Oi, Shinichiro Sasahara, Ichiyo Matsuzaki

    BMC public health   19 ( 1 )   919 - 919   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: A growing body of evidence has demonstrated the associations between social capital and health. In residential or geographical areas, social capital has attracted attention for its protective effects against suicide. However, to this date, the relationship between social capital and suicidal ideation is not fully elaborated in the occupational setting. Therefore, the aim of the present study was to examine the association between workplace social capital and suicidal ideation in the past year among employees in Japan. METHODS: A cross-sectional, web-based survey was conducted in February/March 2017 via an anonymous self-administered questionnaire distributed to workers in Tsukuba Science City, Japan. Binomial logistic regressions were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for suicidal ideation in the past year, controlling for age group, marital status, educational attainment, and annual household income. The results were shown stratified by sex and occupation. RESULTS: In total, 7255 of 19,481 workers responded, out of which we could analyze 6325 responses (4030 men, 2295 women). The prevalence of suicidal ideation in the past year was 5.9% for men and 7.8% for women. Low workplace social capital was statistically significantly associated with suicidal ideation both for men (OR = 2.57, 95% CI = 1.72-3.83) and for women (OR = 1.75, 95% CI = 1.15-2.66), compared with high workplace social capital after controlling for socioeconomic factors. CONCLUSION: Higher workplace social capital was associated with a reduced risk of suicidal ideation in the past year. Promoting workplace social capital could contribute to preventing suicide among employees in Japan.

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  • Reciprocity of social support is associated with psychological distress and suicidal ideation in older Japanese people: A population-based study. 国際誌

    Yuki Mizuno, Hiroyuki Hikichi, Masayuki Noguchi, Ichiro Kawachi, Soshi Takao

    Social science & medicine (1982)   230   131 - 137   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.socscimed.2019.04.010

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  • Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis. 査読 国際誌

    Koyama T, Kariya S, Sato Y, Gion Y, Higaki T, Haruna T, Fujiwara T, Minoura A, Takao S, Orita Y, Kanai K, Taniguchi M, Nishizaki K, Okano M

    Allergology international : official journal of the Japanese Society of Allergology   68 ( 2 )   216 - 224   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Risk factors of thrombosis in a single method of microsurgical head and neck reconstruction: A multi-institutional study of 773 reconstructions with a free jejunal graft after total pharyngolaryngoesophagectomy for hypopharyngeal cancer 査読

    Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   38 ( 11 )   1688 - 1694   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Background. The risk factors for thrombus formation in anastomotic vessels in free-flap head and neck reconstruction have been previously reported. However, the evidence is inconsistent.
    Methods. In total, 773 patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled at 12 institutions in Japan from 1995 to 2006. Both the resection area and the applied reconstruction method were constrained to overcome the limitations of previous studies. After the exclusion of recurrent cases, odds ratios (ORs) and 95% confidence intervals (CIs) for thrombosis were calculated in a multivariate logistic regression analysis.
    Results. Postoperative anastomotic thrombosis developed in 23 patients (3.0%). In the multivariate analysis, the OR for thrombosis per 100-mL increase in blood loss was 1.24 (95% CI = 1.02-1.51), even after controlling for other risk factors.
    Conclusion. Our results show that the blood loss volume is an independent risk factor for thrombosis in free tissue grafts. (C) 2016 Wiley Periodicals, Inc.

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  • Correction: Community-Level Social Capital and Psychological Distress among the Elderly in Japan: A Population-Based Study 国際共著 国際誌

    Tomoko Kobayashi, Etsuji Suzuki, Masayuki Noguchi, Ichiro Kawachi, Soshi Takao

    PLOS ONE   10 ( 12 )   e0144683 - e0144683   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Home visits by commissioned welfare volunteers and psychological distress: a population-based study of 11,312 community-dwelling older people in Japan 査読

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Soshi Takao

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   30 ( 12 )   1156 - 1163   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveNovel countermeasures to increase healthcare expenditures should be explored in rapidly aging societies, including Japan. Social support is a resource for the older people that effectively reduces psychological distress, with or without specialized health service provision. This cross-sectional study was conducted to determine whether home visits by commissioned welfare volunteers (organizations of community residents assigned by national or local governments) are associated with a lower risk of psychological distress among the older people.
    MethodsQuestionnaires were sent in August 2010 to all residents aged 65years in three municipalities (n=21,232) in Okayama Prefecture in Japan; 13,929 were returned (response rate=65.6%). The final sample size for the analysis was 11,312 participants. Home visits, psychological distress (Kessler Psychological Distress Scale: K6&gt;5), and severe psychological distress (K6&gt;13) were measured by the questionnaire. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for psychological distress, adjusting for age, gender, education, marital status, and qualification for long-term care insurance.
    ResultsThe prevalence was 41.4% for psychological distress and 6.5% for severe psychological distress among all participants. Home visits were significantly associated with a lower risk of psychological distress after adjusting for the covariates (OR: 0.71, 95% CI: 0.65-0.77). These associations were comparable for men and women. The association was clearer for severe psychological distress (OR: 0.51, 95% CI: 0.43-0.61).
    ConclusionsHome visits by commissioned welfare volunteers are significantly associated with a lower risk of psychological distress among older people. Copyright (c) 2015 John Wiley & Sons, Ltd.

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  • Community-Level Social Capital and Psychological Distress among the Elderly in Japan: A Population-Based Study 査読

    Tomoko Kobayashi, Etsuji Suzuki, Masayuki Noguchi, Ichiro Kawachi, Soshi Takao

    PLOS ONE   10 ( 11 )   e0142629   2015年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Despite accumulating evidence, previous studies have not clearly separated the contribution of community-level social capital on mental health from that of individual-level social support. We examined the association between community-level social capital and psychological distress in a sample of older Japanese individuals, taking into account the effects of individual-level social capital and social support. We collected data via a cross-sectional survey among all residents aged >= 65 in three rural municipalities in Okayama Prefecture. We measured two components of social capital in the questionnaire: perceptions of trust and reciprocity in the community. Community-level social capital was obtained by aggregating individual responses and calculating the proportion of subjects reporting mistrust and lack of reciprocity. Psychological distress was assessed by the Kessler Psychological Distress scale. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) for psychological distress using two-level Poisson regression models (9,761 individuals nested within 35 communities). The prevalence of psychological distress was 39.8%. Low community-level social capital was associated with psychological distress, even after controlling for individual-level social support, age, sex, educational attainment, frequency of alcohol consumption, smoking status, body mass index, marital status, socioeconomic status, and number of cohabiters. The adjusted RRs per 10% increase of the proportion of mistrust and lack of reciprocity in the communities were 1.23 (95% CI: 1.01-1.51) and 1.12 (95% CI: 1.02-1.24), respectively. Lower levels of community-level social capital are associated with psychological distress among the Japanese elderly population, even after adjusting for individual- level perceptions of social capital and social support.

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  • Prospective Evaluation of Zoledronic Acid in the Treatment of Bone Metastases from Differentiated Thyroid Carcinoma. 査読 国際誌

    Yorihisa Orita, Iwao Sugitani, Soshi Takao, Kazuhisa Toda, Jun Manabe, Satoshi Miyata

    Annals of surgical oncology   22 ( 12 )   4008 - 13   2015年11月

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    記述言語:英語  

    PURPOSE: The objectives of this study were to prospectively delineate the efficacy and safety of zoledronic acid for treating bone metastases (BM) from differentiated thyroid carcinoma (DTC), and to evaluate the relationships between levels of bone metabolic markers and occurrence of skeletal-related events (SREs). METHODS: This was a prospective, single-arm, single-center study. Nineteen patients with BM from DTC were assigned to receive zoledronic acid therapy every 4-5 weeks. Imaging studies for sites of BM were conducted every 6 months, and levels of bone metabolic markers, including serum bone-specific alkaline phosphatase (BAP) and urinary N-telopeptide of type I collagen (NTx), were assessed every 3 months. To evaluate the efficacy of zoledronic acid use, data of SREs were compared with those of 16 historical controls. RESULTS: SREs developed in eight patients (42 %), but metastatic spinal cord compression (MSCC) appeared in only one patient. Pain scores were ameliorated in five patients, but aggravated in six patients. Ten patients had stable disease, six showed progressive disease, and none showed partial or complete response during the observation period. Decreases in levels of bone metabolic markers were observed in ten patients for BAP and 15 for NTx. However, no significant correlations were identified between changes in bone metabolic marker levels and development of SREs. CONCLUSIONS: Zoledronic acid may offer a mainstay of multidisciplinary treatment for patients with BM for the purpose of reducing SREs. Levels of serum BAP and urinary NTx do not appear reliable as indicators of amelioration of BM symptoms.

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  • How long should we continue S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck?

    Misato Hirai, Yorihisa Orita, Soshi Takao, Tomoyasu Tachibana, Hidenori Marunaka, Seiichiro Makihara, Kentaro Miki, Yasuyuki Noyama, Sayaka Fuji, Akiko Torigoe, Yasuharu Sato, Kazunori Nishizaki

    ACTA OTO-LARYNGOLOGICA   135 ( 10 )   1079 - 1085   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Conclusion: It appears that patients with SCCHN should be recommended to take S-1 for more than 1 year and, if possible, more than 2 years, as adjuvant chemotherapy for SCCHN. Objectives: There is no established consensus on the duration of administration of S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck (SCCHN). Since it might be difficult to undergo prospective randomized study to identify the optimal duration of the administration period of S-1 without a standard, the authors have undergone a retrospective clinical study to decide the tentative standard of therapeutic duration of S-1 as adjuvant chemotherapy for SCCHN. Methods: The clinical records of 89 patients with SCCHN who underwent adjuvant chemotherapy with S-1 were investigated. Results: The median duration of S-1 administration as adjuvant chemotherapy for SCCHN was 7 months (range = 0.1-58 months). Disease-free survivals (DFSs) were generally longer when S-1 administration periods were longer. After adjusting for prognostic factors, S-1 administration periods of 24 months or longer showed significantly lower hazard ratios (HRs) than 0-12 months.

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  • Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients

    H. Hanakawa, Y. Orita, Y. Sato, M. Takeuchi, S. Takao, K. Ohno, T. Kohno, N. Iwaki, H. Marunaka, R. Tamamura, M. Nishibori, H. Nagatsuka, K. Nishizaki, T. Yoshino

    Journal of Laryngology and Otology   128 ( 10 )   926 - 931   2014年10月

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    掲載種別:研究論文(学術雑誌)  

    Objective: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion. Methods: A case-control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated. Results: Results for HMGB1 were dichotomised into positive staining scores (score, 5-7) and negative scores (0-4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6-26.5) after adjusting for other factors. Conclusion: In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.

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  • Novel and simple prognostic index for nasal natural killer/T- cell lymphoma

    Hiroyuki Hanakawa, Yorihisa Orita, Yasuharu Sato, Soshi Takao, Hidenori Marunaka, Tokiwa Morishita, Yasuhiko Yamashita, Yasutaka Hori, Shuhei Domae, Ikuo Inokuchi, Seiko Akagi, Eisei Kondo, Noriko Iwaki, Kana Motomiya, Hirokazu Okumura, Tadashi Yoshino, Kazunori Nishizaki

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   36 ( 4 )   551 - 556   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BackgroundFew studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma.
    MethodsThis was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals.
    ResultsHigh serum levels of C-reactive protein (1.0 mg/dL), lactate dehydrogenase (350 IU/L), and soluble interleukin-2 receptor (sIL-2R; 600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2.
    ConclusionOur NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma. (c) 2013 Wiley Periodicals, Inc. Head Neck36: 551-556, 2014

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  • Social support and suicidal ideation in Japan: are home visits by commissioned welfare volunteers associated with a lower risk of suicidal ideation among elderly people in the community?

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Yoko Kishimoto, Soshi Takao

    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY   49 ( 4 )   619 - 627   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER HEIDELBERG  

    Aims Social support has consistently been reported to be effective in reducing suicidal ideation. This cross-sectional study was performed to determine whether home visits by commissioned welfare volunteers (i.e., organizations of community residents appointed by national or prefectural governments) are associated with a lower risk of suicidal ideation among the elderly.
    Methods In August 2010, questionnaires were sent to all residents aged &gt;= 65 years in three municipalities (n = 21,232) in Okayama prefecture, Japan, and 13,929 returned the questionnaire (response rate: 65.6 %). We finally analyzed 11,218 subjects. Both home visits by commissioned welfare volunteers and suicidal ideation within the last 30 days were assessed in the questionnaire. Odds ratios (ORs) and 95 % confidence intervals (CIs) for suicidal ideation were calculated adjusting for age, sex, educational attainment, and marital status. We then additionally adjusted for instrumental and emotional support, separately.
    Results The prevalence of suicidal ideation was 10.0 % and higher in women than in men (11.4 % vs. 8.0 %). Home visits were significantly associated with a lower risk of suicidal ideation after adjusting for instrumental and emotional support, respectively (OR: 0.60, 95 % CI: 0.53-0.69; OR: 0.67, 95 % CI: 0.59-0.78). In sex-stratified analysis, the association was clearer for women than for men: the corresponding ORs among women were 0.55 (95 % CI: 0.46-0.65) and 0.61 (95 % CI: 0.52-0.73), whereas they were 0.71 (95 % CI: 0.56-0.90) and 0.78 (95 % CI: 0.61-0.99) among men.
    Conclusion Our findings suggest that home visits by commissioned welfare volunteers are significantly associated with lower suicidal ideation among the elderly, particularly in women.

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  • The Bright Side and Dark Side of Workplace Social Capital: Opposing Effects of Gender on Overweight among Japanese Employees

    Tomoko Kobayashi, Etsuji Suzuki, Tuula Oksanen, Ichiro Kawachi, Soshi Takao

    PLOS ONE   9 ( 1 )   e88084   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: A growing number of studies have sought to examine the health associations of workplace social capital; however, evidence of associations with overweight is sparse. We examined the association between individual perceptions of workplace social capital and overweight among Japanese male and female employees.
    Methodology/Principal Findings: We conducted a cross-sectional survey among full-time employees at a company in Osaka prefecture in February 2012. We used an 8-item measure to assess overall and sub-dimensions of workplace social capital, divided into tertiles. Of 1050 employees, 849 responded, and 750 (624 men and 126 women) could be linked to annual health check-up data in the analysis. Binomial logistic regression models were used to calculate odds ratios and 95% confidence intervals for overweight (body mass index: &gt;= 25 kg/m(2), calculated from measured weight and height) separately for men and women. The prevalence of overweight was 24.5% among men and 14.3% among women. Among men, low levels of bonding and linking social capital in the workplace were associated with a nearly 2-fold risk of overweight compared to high corresponding dimensions of social capital when adjusted for age, sleep hours, physiological distress, and lifestyle. In contrast, among women we found lower overall and linking social capital to be associated with lower odds for overweight even after covariate adjustment. Subsequently, we used multinomial logistic regression analyses to assess the relationships between a 1 standard deviation (SD) decrease in mean social capital and odds of underweight/overweight relative to normal weight. Among men, a 1-SD decrease in overall, bonding, and linking social capital was significantly associated with higher odds of overweight, but not with underweight. Among women, no significant associations were found for either overweight or underweight.
    Conclusions/Significance: We found opposite gender relationships between perceived low linking workplace social capital and overweight among Japanese employees.

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  • Group involvement and self-rated health among the Japanese elderly: an examination of bonding and bridging social capital

    Yoko Kishimoto, Etsuji Suzuki, Toshihide Iwase, Hiroyuki Doi, Soshi Takao

    BMC PUBLIC HEALTH   13   1189   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background: To date, only a small amount of research on bonding/bridging social capital has separately examined their effects on health though they have been thought to have differential effects on health outcomes. By using a large population-based sample of elderly Japanese people, we sought to investigate the association between bonding and bridging social capital and self-rated health for men and women separately.
    Methods: In August 2010, questionnaires were sent to all residents aged &gt;= 65 years in three municipalities in Okayama prefecture (n = 21232), and 13929 questionnaires were returned (response rate: 65.6%). Social capital was measured from survey responses to questions on participation in six different types of groups: a) the elderly club or sports/hobby/culture circle; b) alumni association; c) political campaign club; d) citizen's group or environmental preservation activity; e) community association; and f) religious organization. Participant perception of group homogeneity (gender, age, and previous occupation) was used to divide social capital into bonding or bridging. Odds ratios (ORs) and 95% confidence intervals (CIs) for poor self-rated health were calculated.
    Results: A total of 11146 subjects (4441 men and 6705 women) were available for the analysis. Among men, bonding and bridging social capital were inversely associated with poor self-rated health (high bonding social capital; OR: 0.55, 95% CI: 0.31-0.99; high bridging social capital; OR: 0.62, 95% CI: 0.48-0.81) after adjusting for age, educational attainment, smoking status, frequency of alcohol consumption, overweight, living arrangements, and type-D personality. The beneficial effect among women was more likely limited to bonding social capital (high bonding social capital; OR: 0.34, 95% CI: 0.12-1.00), and the association between bridging social capital and self-rated health was less clear (high bridging social capital; OR: 0.69, 95% CI: 0.44-1.07).
    Conclusions: Bonding/bridging social capital could have differential associations with self-rated health among the Japanese elderly depending on the individual's sex. Considering the lack of consensus on how to measure bonding and bridging social capital, however, we need to carefully assess the generalizability of our findings. Further research is warranted to identify health-relevant dimensions of social capital in different cultural or economic settings.

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  • Workplace Determinants of Social Capital: Cross-Sectional and Longitudinal Evidence from a Finnish Cohort Study

    Tuula Oksanen, Ichiro Kawachi, Anne Kouvonen, Soshi Takao, Etsuji Suzuki, Marianna Virtanen, Jaana Pentti, Mika Kivimaki, Jussi Vahtera

    PLOS ONE   8 ( 6 )   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Objective: To examine which contextual features of the workplace are associated with social capital.Methods: This is a cohort study of 43,167 employees in 3090 Finnish public sector workplaces who responded to a survey of individual workplace social capital in 2000-02 (response rate 68%). We used ecometrics approach to estimate social capital of work units. Features of the workplace were work unit's demographic and employment patterns and size, obtained from employers' administrative records. We used multilevel-multinomial logistic regression models to examine cross-sectionally whether these features were associated with social capital between individuals and work units. Fixed effects models were used for longitudinal analyses in a subsample of 12,108 individuals to examine the effects of changes in workplace characteristics on changes in social capital between 2000 and 2004.Results: After adjustment for individual characteristics, an increase in work unit size reduced the odds of high levels of individual workplace social capital (odds ratio 0.94, 95% confidence interval 0.91-0.98 per 30-person-year increase). A 20% increase in the proportion of manual and male employees reduced the odds of high levels of social capital by 8% and 23%, respectively. A 30% increase in temporary employees and a 20% increase in employee turnover were associated with 11% (95% confidence interval 1.04-1.17) and 24% (95% confidence interval 1.18-1.30) higher odds of having high levels of social capital respectively). Results from fixed effects models within individuals, adjusted for time-varying covariates, and from social capital of the work units yielded consistent results.Conclusions: These findings suggest that workplace social capital is contextually patterned. Workplace demographic and employment patterns as well as the size of the work unit are important in understanding variations in workplace social capital between individuals and workplaces.

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  • Individual-level social capital and self-rated health in Japan: An application of the Resource Generator

    Tomoko Kobayashi, Ichiro Kawachi, Toshihide Iwase, Etsuji Suzuki, Soshi Takao

    SOCIAL SCIENCE & MEDICINE   85   32 - 37   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Despite accumulating evidence of associations between social capital and health in public health research, a criticism of the field has been that researchers have exclusively focused on concepts of social cohesion to the exclusion of individual-level approaches. In the present study, we evaluated the association between social capital measured by the Resource Generator (an individual-level assessment of access to social capital) and self-rated health among Japanese population in a cross-sectional study. A postal survey of 4000 randomly selected residents in Okayama City (western Japan) was conducted in February 2009. We divided the overall scores from the Resource Generator Japan scale into quartiles. Odds ratios (ORs) and 95% confidence intervals (CIs) for self-rated health were calculated separately by sex. Individuals with the highest quartile of scores had significantly lower odds of poor health compared to the lowest group after covariate adjustment among both men and women (men; OR: 0.45, 95% CI: 0.24-0.86, women; OR: 0.44, 95% CI: 0.25-0.79, respectively) and there were also significant dose-response relationships. In the sub-domains of Resource Generator Japan scale, a differential pattern was observed by sex. Women showed a clear dose response relationship with health across all four sub-scales (domestic resources, expert advice, personal skills, and problem solving resources). In contrast, only the domain of expert advice exhibited a strong association with men's health. Among both men and women individual-level social capital measured by the Resource Generator was related to reduced odds of poor health even after taking into account individual confounders. Although we cannot exclude reverse causation due to the cross-sectional design, our study adds to the accumulating evidence of the potential utility of the Resource Generator for evaluating the relationship between individual-level access to social capital and health. (C) 2013 Elsevier Ltd. All rights reserved.

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  • Residential proximity to major roads and adverse birth outcomes: a hospital-based study 査読

    Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Soshi Takao, Takeshi Murakoshi, Hiroyuki Doi, Ichiro Kawachi

    ENVIRONMENTAL HEALTH   12 ( 34 )   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background: Exposure to air pollution has been demonstrated to increase the risk of preterm birth and low birth weight (LBW). Although evidence has accumulated on characteristics associated with increased risk of air pollution-related health effects, most studies have been conducted in the adult population and evidence on reproductive outcomes is limited. We examined whether socio-economic position (SEP) and parental characteristics (parental behavior and co-morbidity) modified the relationship between air pollution and adverse birth outcomes. Methods: Data were extracted from a perinatal hospital database based in Shizuoka, Japan. We restricted the analysis to mothers who delivered live-born single births from January 1997 to December 2010 (n = 16,615). Each birth was assigned proximity to major roads. Multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated for the outcomes of preterm birth and term LBW. We stratified subjects by individual/area-level SEP and parental characteristics. We then measured interactions on the additive scale between the respective factors and exposure. Results: Lower SEP at both individual and area levels was asso

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  • Shift Work and Diabetes Mellitus among Male Workers in Japan: Does the Intensity of Shift Work Matter? 査読

    Katsuhiko Ika, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Hiroyuki Doi

    ACTA MEDICA OKAYAMA   67 ( 1 )   25 - 33   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purpose of this study was to examine the association between shift work and diabetes mellitus by separating shift workers according to the intensity of their shift work (seasonal shift work and continuous shift work). Between May and October 2009, we collected data from annual health checkups and questionnaires at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate: 96.2%, men/women = 1,314/287). Diabetes mellitus was defined as hemoglobin Alc &gt;= 6.5% and fasting blood sugar &gt;= 126 mg/dl. After exclusions, which included all the women and clerical workers because they did not work in shifts, we analyzed 475 skilled male workers. After adjusting for age, smoking status, frequency of alcohol consumption, and cohabitation status, odds ratios for diabetes mellitus were 0.98 (95% confidence interval [CI]: 0.28-4.81) and 2.10 (95% CI: 0.77-5.71) among seasonal shift workers and continuous shift workers, respectively, compared with non-shift workers. In an age-stratified analysis (&lt; 45 years vs. &gt;= 45 years), the association between continuous shift work and diabetes mellitus was more pronounced among older participants. Compared with non-shift workers, the risk of diabetes mellitus was increased among continuous shift workers, whereas its effect is limited among seasonal shift workers.

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  • Critical Appraisal of the 1977 Diagnostic Criteria for Minamata Disease

    Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada, Ichiro Kawachi

    ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH   68 ( 1 )   22 - 29   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD  

    Large-scale food poisoning caused by methylmercury was identified in Minamata, Japan, in the 1950s (Minamata disease). Although the diagnostic criteria for the disease remain current, few studies have been carried out to assess the diagnostic accuracy of the criteria. From a 1971 population-based investigation, data from 2 villages were selected: Minamata (high-exposure area; n = 779) and Ariake (low-exposure area; n = 755). The authors examined the prevalence of neurologic signs characteristic of methylmercury poisoning and the validity of the criteria. A substantial number of residents in the exposed area exhibited neurologic signs even after excluding officially certified patients. Using paresthesia of the extremities as the gold standard of diagnosis, the criteria had a sensitivity of 66%. The current diagnostic criteria as well as the official certification system substantially underestimate the incidence of Minamata disease.

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  • Contribution of smoking to the gender gap in life expectancy in Japan 査読

    Yorifuji, T, Takao, S, Inoue, S, Tanihara, S, Kawachi, I

    Public Health   127 ( 5 )   482 - 484   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Clarifying the Use of Aggregated Exposures in Multilevel Models: Self-Included vs. Self-Excluded Measures

    Etsuji Suzuki, Eiji Yamamoto, Soshi Takao, Ichiro Kawachi, S. V. Subramanian

    PLOS ONE   7 ( 12 )   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: Multilevel analyses are ideally suited to assess the effects of ecological (higher level) and individual (lower level) exposure variables simultaneously. In applying such analyses to measures of ecologies in epidemiological studies, individual variables are usually aggregated into the higher level unit. Typically, the aggregated measure includes responses of every individual belonging to that group (i.e. it constitutes a self-included measure). More recently, researchers have developed an aggregate measure which excludes the response of the individual to whom the aggregate measure is linked (i.e. a self-excluded measure). In this study, we clarify the substantive and technical properties of these two measures when they are used as exposures in multilevel models.Methods: Although the differences between the two aggregated measures are mathematically subtle, distinguishing between them is important in terms of the specific scientific questions to be addressed. We then show how these measures can be used in two distinct types of multilevel models-self-included model and self-excluded model-and interpret the parameters in each model by imposing hypothetical interventions. The concept is tested on empirical data of workplace social capital and employees' systolic blood pressure.Results: Researchers assume group-level interventions when using a self-included model, and individual-level interventions when using a self-excluded model. Analytical re-parameterizations of these two models highlight their differences in parameter interpretation. Cluster-mean centered self-included models enable researchers to decompose the collective effect into its within-and between-group components. The benefit of cluster-mean centering procedure is further discussed in terms of hypothetical interventions.Conclusions: When investigating the potential roles of aggregated variables, researchers should carefully explore which type of model-self-included or self-excluded-is suitable for a given situation, particularly when group sizes are relatively small.

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  • Workplace social capital and risk of chronic and severe hypertension: a cohort study

    Tuula Oksanen, Ichiro Kawachi, Markus Jokela, Anne Kouvonen, Etsuji Suzuki, Soshi Takao, Marianna Virtanen, Jaana Pentti, Jussi Vahtera, Mika Kivimaki

    JOURNAL OF HYPERTENSION   30 ( 6 )   1129 - 1136   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: The association between workplace factors and the development of hypertension remains uncertain. We examined the risk of hypertension as a function of workplace social capital, that is, social cohesion, trust and reciprocity in the workplace.
    Methods: A total of 11 777 male and 49 145 female employees free of chronic hypertension at baseline in 2000-2004 were followed up for incident hypertension until the end of 2005 (the Finnish Public Sector Study). We used survey responses from the participants and their coworkers in the same work unit to assess workplace social capital at baseline. Follow-up for incident hypertension was based on record linkage to national health registers (mean follow-up 3.5 years, 1424 incident hypertension cases).
    Results: Male employees in work units characterized by low workplace social capital were 40-60% more likely to develop chronic hypertension compared to men in work units with high social capital [age-adjusted hazard ratio 1.57, 95% confidence interval (CI) 1.15-2.14 for self-assessed social capital and 1.41, 95% CI 1.01-1.97 for coworkers' assessment]. According to path analysis adjusted for covariates, the association between low self-reported social capital and hypertension was partially mediated by obesity (P for pathway = 0.02) and alcohol consumption (P = 0.03). For coworker-assessed social capital, the corresponding mediation pathways did not reach statistical significance (P = 0.055 and 0.22, respectively). No association between workplace social capital and hypertension was found for women.
    Conclusion: These data suggest that low self-reported workplace social capital is associated with increased near-term risk of hypertension in men in part due to unhealthy lifestyle.

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  • Clarifying the use of aggregated exposures in multilevel models: self-included vs. self-excluded measures 査読 国際共著 国際誌

    Etsuji Suzuki, Eiji Yamamoto, Soshi Takao, Ichiro Kawachi, S. V. Subramanian

    American Journal of Epidemiology   175 ( Suppl 11 )   S17 - S17   2012年6月

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

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  • Long working hours and metabolic syndrome among Japanese men: a cross-sectional study

    Tomoko Kobayashi, Etsuji Suzuki, Soshi Takao, Hiroyuki Doi

    BMC PUBLIC HEALTH   12   395   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background: The link between long working hours and health has been extensively studied for decades. Despite global concern regarding metabolic syndrome, however, no studies to date have solely evaluated the relationship between long working hours and that syndrome. We therefore examined the association between long working hours and metabolic syndrome in a cross-sectional study.
    Methods: Between May and October 2009, we collected data from annual health checkups and questionnaires from employees at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate: 96.2%; 1,314 men, 287 women). After exclusions, including women because of a lack of overtime work, the analysis was performed for 933 men. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for metabolic syndrome. Further, we conducted a stratified analysis by age-group (&lt;40 years vs. &gt;= 40 years).
    Results: Metabolic syndrome was identified in 110 workers (11.8%). We observed a positive association between working hours and metabolic syndrome after adjusting for age, occupation, shift work, smoking status, frequency of alcohol consumption, and cohabiting status. Compared with subjects who worked 7-8 h/day, multivariate ORs for metabolic syndrome were 1.66 (95% CI, 0.91-3.01), 1.48 (95% CI, 0.75-2.90), and 2.32 (95% CI, 1.04-5.16) for those working 8-9 h/day, 9-10 h/day, and &gt;10 h/day, respectively. Similar patterns were obtained when we excluded shift workers from the analysis. In age-stratified analysis, the corresponding ORs among workers aged &gt;= 40 years were 2.02 (95% CI, 1.04-3.90), 1.21 (95% CI, 0.53-2.77), and 3.14 (95% CI, 1.24-7.95). In contrast, no clear association was found among workers aged &lt;40 years.
    Conclusions: The present study suggests that 10 h/day may be a trigger level of working hours for increased risk of metabolic syndrome among Japanese male workers.

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  • Does Open-air Exposure to Volatile Organic Compounds near a Plastic Recycling Factory Cause Health Effects? (vol 54, pg 79, 2012)

    Takashi Yorifuji, Miyuki Noguchi, Toshihide Tsuda, Etsuji Suzuki, Soshi Takao, Saori Kashima, Yukio Yanagisawa

    JOURNAL OF OCCUPATIONAL HEALTH   54 ( 3 )   254 - 254   2012年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

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  • Does Open-air Exposure to Volatile Organic Compounds near a Plastic Recycling Factory Cause Health Effects? 査読

    Takashi Yorifuji, Miyuki Noguchi, Toshihide Tsuda, Etsuji Suzuki, Soshi Takao, Saori Kashima, Yukio Yanagisawa

    JOURNAL OF OCCUPATIONAL HEALTH   54 ( 2 )   79 - 87   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Does Open-air Exposure to Volatile Organic Compounds near a Plastic Recycling Factory Cause Health Effects?: Takashi YORIFUJI, et al. Department of Human Ecology, Okayama University Graduate School of Environmental Sciences-Objectives: After a plastic reprocessing factory began to operate in August 2004, the residents around the factory in Neyagawa, Osaka, Japan, began to complain of symptoms. Therefore, we conducted an exposure assessment and a population-based epidemiological study in 2006. Methods: To assess exposure, volatile organic compounds (VOCs) and total VOCs were measured at two locations in the vicinity of the factory. In the population-based study, a total of 3,950 residents were targeted. A self-administered questionnaire was used to collect information about subjects' mucocutaneous or respiratory symptoms. Using logistic regression models, we compared the prevalence of symptoms in July 2006 by employing the farthest area from the factory as a reference, and prevalence odds ratios (PORs) and their 95% confidence intervals (Cis) were estimated. Results: The concentration of total VOCs was higher in the vicinity of the factory. The prevalence of mucocutaneous and respiratory symptoms was the highest among the residents in the closest area to the factory. Some symptoms were significantly increased among the residents within 500 m of the factory compared with residents of an area 2800 m from the factory: e.g., sore throat (POR=3.2, 95% CI: 1.3-8.0), eye itch (POR=3.0, 95% CI: 1.5-6.0), eye discharge (POR=6.0, 95% CI: 2.3-15.9), eczema (POR=3.0, 95% CI: 1.1-7.9) and sputum (POR=2.4, 95% CI: 1.1-5.1). Conclusions: Despite of the limitations of this study, these results imply a possible association of open-air VOCs with mucocutaneous and respiratory symptoms. Because this kind of plasticre cycling factory only recently came into operation, more attention should be paid to the operation of plastic recycling factories in the environment. (J Occup Health 2012; 54: 79-87)

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  • Maternal Working Hours and Early Childhood Overweight in Japan: A Population-based Study 査読

    Toshiharu Mitsuhashi, Etsuji Suzuki, Soshi Takao, Hiroyuki Doi

    JOURNAL OF OCCUPATIONAL HEALTH   54 ( 1 )   25 - 33   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Maternal Working Hours and Early Childhood Overweight in Japan: A Population-based Study: Toshiharu MITSUHASHI, et al. Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Objectives: There has been a growing concern that maternal employment could have adverse or beneficial effects on children's health. Although recent studies demonstrated that maternal employment was associated with a higher risk of childhood overweight, the evidence remains sparse in Asian countries. We sought to examine the relationship between maternal working hours and early childhood overweight in a rural town in Okayama Prefecture. Methods: In February 2008, questionnaires were sent to parents of all preschool children aged &gt;= 3 yr in the town to assess maternal working status (working hours and form of employment), children's body mass index, and potential confounders. Childhood overweight was defined following the age and sex-specific criteria of the International Obesity Task Force. Odds ratios (ORs) and 95% confidence intervals (CIs) for childhood overweight were estimated in a logistic regression. We used generalized estimating equations with an exchangeable correlation matrix, considering the correlation between siblings. Results: We analyzed 364 preschool children. Adjusting for each child's characteristics (age, sex), mother's characteristics (age, obesity, educational attainment, smoking status, and social participation), and family's characteristics (number of siblings), children whose mothers work &lt;8 h/day had a substantially lower risk for being overweight (OR: 0.28, 95% CI: 0.09, 0.93) compared with children of non-working mothers, whereas the relationship was less pronounced among children whose mothers work &gt;= 8 h/day (OR: 0.71, 95% CI: 0.19, 2.68). We observed similar patterns in a stratified analysis by the form of maternal employment. Conclusion: Short maternal working hours are associated with a lower odds of early childhood overweight. (J Occup Health 2012; 54: 25-33)

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  • Does Caregiver's social bonding enhance the health of their children?: The association between social capital and child behaviors

    Takeo Fujiwara, Soshi Takao, Toshihide Iwase, Jun Hamada, Ichiro Kawachi

    Acta Medica Okayama   66 ( 4 )   343 - 350   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Little is known about the association between social capital and child behaviors. This study aims to investigate that association A complete population-based, cross-sectional survey was conducted for all the caregivers with preschool children in a rural town in Okayama prefecture in Japan. Two dimensions of individual-level social capital and unhealthy child behaviors were reported by parent-administered questionnaire. We analyzed 354 preschool children (57.6% of all children for whom questionnaires were completed). Children whose main caregiver had high cognitive social capital were 89% less likely to miss breakfast (odds ratio [OR] =0.11
    95% confidence interval [CI]: 0.01-1.03). Children whose caregiver had high structural social capital were 71 % less likely to wake up late (OR = 0.29
    95% CI: 0.120.71) and 78% less likely to skip tooth brushing more than once per day (OR = 0.22
    95% CI: 0.05-0.93). Both cognitive and structural social capital were negatively associated with unhealthy child behaviors. A further intervention study is needed to confirm the impact of social capital on child behavior.©2012 by Okayama University Medical School.

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  • The role of medicine in the decline of post-War infant mortality in Japan 査読

    Takashi Yorifuji, Shinichi Tanihara, Sachiko Inoue, Soshi Takao, Ichiro Kawachi

    PAEDIATRIC AND PERINATAL EPIDEMIOLOGY   25 ( 6 )   601 - 608   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Yorifuji T, Tanihara S, Inoue S, Takao S, Kawachi I. The role of medicine in the decline of post-War infant mortality in Japan. Paediatric and Perinatal Epidemiology 2011; 25: 601-608.
    The infant mortality rate (IMR) in Japan declined dramatically in the immediate post-War period (1947-60) in Japan. We compared the time trends in Growth Domestic Product (GDP) in Japan against declines in IMR. We then conducted a prefecture-level ecological analysis of the rate of decline in IMR and post-neonatal mortality from 1947 to 1960, focusing on variations in medical resources and public health strategies. IMR in Japan started to decline after World War II, even before the era of rapid economic growth and the introduction of a universal health insurance system in the 1960s. The mortality rates per 1000 infants in 2009 were 2.38 for IMR, 1.17 for neonatal mortality and 1.21 for post-neonatal mortality. The rate of decline in IMR and preventable IMR (PIMR) during the post-War period was strongly correlated with prefectural variations in medical resources (per capita physicians, nurses, and proportion of in-hospital births). The correlation coefficients comparing the number of physicians in 1955 with the declines in IMR and PIMR from 1947 to 1960 were 0.46 [95% confidence interval (CI) 0.19, 0.66] and 0.39 [95% CI 0.11, 0.61], respectively. By contrast, indicators of public health strategies were not associated with IMR decline. The IMR in Japan has been decreasing and seems to be entering a new era characterised by lower neonatal compared with post-neonatal mortality. Furthermore, the post-War history of Japan illustrates that improvement in infant mortality is attributable to the influence of medical care, even in the absence of rapid economic development.

    DOI: 10.1111/j.1365-3016.2011.01216.x

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  • Workplace Social Capital and Adherence to Antihypertensive Medication: A Cohort Study

    Tuula Oksanen, Ichiro Kawachi, Anne Kouvonen, Etsuji Suzuki, Soshi Takao, Noora Sjosten, Marianna Virtanen, Jaana Pentti, Jussi Vahtera, Mika Kivimaki

    PLOS ONE   6 ( 9 )   e24732   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: While hypertension is a common and treatable health problem, adherence to antihypertensive medication remains a challenge. This study examines the hypothesis that workplace social capital may influence adherence to antihypertensive medication among hypertensive employees.
    Methodology/Principal Findings: We linked survey responses to nationwide pharmacy records for a cohort of 3515 hypertensive employees (mean age 53.9 years, 76% women) who required continuous antihypertensive drug therapy (the Finnish Public Sector study). A standard scale was used to measure workplace social capital from co-workers&apos; assessments and self-reports in 2000-2004. Non-adherence to antihypertensive medication was determined based on the number of days-not-treated at the year following the survey using comprehensive prescription records. Negative binomial regression models were conducted adjusting for socio-demographic characteristics, duration of hypertension, behaviour-related risk factors, and co-morbid conditions. The overall rate of days-not-treated was 20.7 per person-year (78% had no days-not-treated). Higher age, obesity, and presence of somatic co-morbidities were all associated with better adherence, but this was not the case for co-worker-assessed or self-reported workplace social capital. The rate of days-not-treated was 19.7 per person-year in the bottom fourth of co-worker-assessed workplace social capital, compared to 20.4 in the top fourth. The corresponding rate ratio from the fully-adjusted model was 0.95 (95% confidence interval (CI) 0.58-1.56). In a subgroup of 907 new users of antihypertensive medication this rate ratio was 0.98 (95% CI 0.42-2.29).
    Conclusions/Significance: We found no consistent evidence to support the hypothesized effect of workplace social capital on adherence to drug therapy among employees with chronic hypertension.

    DOI: 10.1371/journal.pone.0024732

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  • Diesel vehicle emission and death rates in Tokyo, Japan: A natural experiment

    Takashi Yorifuji, Ichiro Kawachi, Mariko Kaneda, Soshi Takao, Saori Kashima, Hiroyuki Doi

    SCIENCE OF THE TOTAL ENVIRONMENT   409 ( 19 )   3620 - 3627   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Evidence linking air pollution with adverse cardiopulmonary outcomes is accumulating. However, few studies have been conducted to evaluate whether vehicle emission control improves public health. We thus evaluated the effect of a diesel emission control law on mortality rates in 23 wards of Tokyo metropolitan area, Japan. We obtained daily counts of mortality and concentrations of nitrogen dioxide (NO2) and particulate matter less than 2.5 mu m in diameter (PM2.5) from April 2003 to December 2008. Time-series and interrupted time-series analysis were employed to analyze the data in two periods: prior to the introduction of tighter restrictions (April 2003 to March 2006) and after the enforcement (April 2006 to December 2008). Concentrations of air pollutants gradually decreased during the study period: from 36.3 ppb (NO2) and 22.8 mu g/m(3) (PM2.5) to 32.1 ppb and 20.3 mu g/m(3), respectively. Air pollutants were positively associated with circulatory and pulmonary disease mortality, especially cerebrovascular disease. Each same-day PM2.5 increase of 10 mu g/m(3) was associated with a 1.3% increase in cerebrovascular mortality rate (95% confidence interval: 0.2-2.4). Rate ratios were attenuated after the enforcement in most of the outcomes, probably due to reduced toxicity of the pollutants. In the crude interrupted time-series analysis, reductions of standardized mortality rates after the enforcement were the greatest in high traffic areas. Even after adjustment of longer-time trend, mortality rate from cerebrovascular disease was reduced by 8.50% (p<.001) with dose-response relationship. However, the declines in other cause-specific mortality became equivocal. This natural experiment in Tokyo suggests that emission controls improved air quality. Although suggestive, further data are needed to conclusively demonstrate an impact on mortality rates. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.scitotenv.2011.06.002

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  • Regional disparities in compliance with tobacco control policy in Japan: an ecological analysis 査読

    Takashi Yorifuji, Shinichi Tanihara, Soshi Takao, Ichiro Kawachi

    TOBACCO CONTROL   20 ( 5 )   374 - 379   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:B M J PUBLISHING GROUP  

    Background The slow progress of tobacco control policy in Japan reflects the tension among the interests of the Finance Ministry (which remains the majority shareholder of Japan Tobacco, Inc), the Health Ministry, tobacco growers and consumers.
    Methods We sought to examine regional disparities in compliance with national tobacco control legislation (the 2003 Health Promotion Law). Specifically, we sought to examine whether prefecture-level compliance with legislation was correlated with decreases in smoking prevalence, and decreases in lung cancer mortality rates. We also examined whether prefectural involvement in growing tobacco was associated with lower compliance with the law.
    Results From 2001 to 2007, higher prefectural compliance with tobacco control laws was associated with decreased prevalence of smoking. Decreased tobacco consumption was in turn associated with declining lung cancer mortality. Prefectures involved in growing tobacco exhibited lower levels of compliance with national tobacco control laws. The same prefectures also exhibited the worst improvement in smoking prevalence.
    Conclusions This study in Japan suggests that tobacco control policies are being unevenly implemented across prefectures, and that measures to counteract the influence of local tobacco culture are required to reduce the disparities in regional tobacco control outcomes in that country.

    DOI: 10.1136/tc.2010.041442

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  • Workplace Social Capital and All-Cause Mortality: A Prospective Cohort Study of 28043 Public-Sector Employees in Finland

    Tuula Oksanen, Ichiro Kawachi, S. V. Subramanian, Mika Kivimaki, Jaana Pentti, Paula Salo, Marianna Virtanen, Jussi Vahtera, Soshi Takao, Etsuji Suzuki, Anne Kouvonen

    AMERICAN JOURNAL OF PUBLIC HEALTH   101 ( 9 )   1742 - 1748   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PUBLIC HEALTH ASSOC INC  

    Objectives. We examined the association between workplace social capital and all-cause mortality in a large occupational cohort from Finland.
    Methods. We linked responses of 28043 participants to surveys in 2000 to 2002 and in 2004 to national mortality registers through 2009. We used repeated measurements of self- and coworker-assessed social capital. We carried out Cox proportional hazard and fixed-effects logistic regressions.
    Results. During the 5-year follow-up, 196 employees died. A 1-unit increase in the mean of repeat measurements of self-assessed workplace social capital (range 1-5) was associated with a 19% decrease in the risk of all-cause mortality (age- and gender-adjusted hazard ratio [HR]=0.81; 95% confidence interval [CI) =0.66, 0.99). The corresponding point estimate for the mean of coworker-assessed social capital was similar, although the association was less precisely estimated (age- and gender-adjusted HR=0.77; 95% CI=0.50, 1.20). In fixed-effects analysis, a 1-unit increase in self-assessed social capital across the 2 time points was associated with a lower mortality risk (odds ratio=0.81; 95% CI=0.55, 1.19).
    Conclusions. Workplace social capital appears to be associated with lowered mortality in the working-aged population. (Am J Public Health. 2011;101: 1742-1748. doi:10.2105/AJPH.2011.300166)

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  • Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan 査読

    Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada

    ENVIRONMENT INTERNATIONAL   37 ( 5 )   907 - 913   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Introduction: It is well-known that prenatal or postnatal exposure to methylmercury can produce neurological signs in adults and children, exemplified by a case of large-scale poisoning in Minamata, Japan, in the 1950s. However, evidence regarding whether pre- or postnatal exposure to methylmercury causes psychiatric symptoms (e.g., impairment of intelligence and mood and behavioral dysfunction) is still limited-excluding cases of fetal Minamata disease patients.
    Methods: We evaluated the effects of pre- or postnatal exposure to methylmercury on psychiatric symptoms using data derived from a 1971 population-based survey in Minamata and neighboring communities. We adopted residential areas as an exposure indicator and psychiatric symptoms as the outcome. Then, we estimated the adjusted prevalence odds ratio (POR) and confidence interval (Cl) of psychiatric symptoms in relation to residential area.
    Results: There were 904 participants in Minamata (high exposure area), 1700 in Goshonoura (middle exposure area), and 913 in Ariake (low exposure area). Compared to the Ariake area, participants in the Minamata area manifested psychiatric symptoms more frequently: PORs for impairment of intelligence and mood and behavioral dysfunction were 5.2 (95% Cl: 3.7-7.3) and 4.4 (95% Cl: 2.9-6.7), respectively. Furthermore, participants with psychiatric symptoms in the Minamata area more frequently had neurological signs. Peaks in prevalence of psychiatric symptoms occurred around age 20 and in older age adults in the area. These findings did not change when we excluded those who had been officially certified as Minamata disease patients by that time.
    Conclusions: The present study suggests a relationship between pre- or postnatal exposure to methylmercury and psychiatric symptoms among the general population in Minamata even after excluding officially certified patients. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.envint.2011.03.008

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  • Residential proximity to heavy traffic and birth weight in Shizuoka, Japan 査読

    Saori Kashima, Hiroo Naruse, Takashi Yorifuji, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    ENVIRONMENTAL RESEARCH   111 ( 3 )   377 - 387   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    An association between exposure to traffic-related air pollution and reduced birth weight has been suggested. However, previous studies have failed to adjust for maternal size, which is an indicator of individual genetic growth potential. Therefore, we evaluated the association of air pollution with birth weight, term low birth weight (term-LBW), and small for gestational age (SGA), with adjustment for maternal size. Individual data were extracted from a database that is maintained by a maternal and perinatal care center in Shizuoka, japan. We identified liveborn singleton births (n=14,204). Using geocoded residential information, each birth was assigned a number of traffic-based exposure indicators: distance to a major road; distance-weighted traffic density; and estimated concentration of nitrogen dioxide by land use regression. The multivariate adjusted odds ratios and their 95% confidence intervals (CIs) for the associations between exposure indicators and outcomes were then estimated using logistic regression models. Overall, exposure indicators of air pollution showed no clear pattern of association. Although there are many limitations, we did not find clear associations between birth-weight-related outcomes and the three markers of traffic-related air pollution. (C) 2011 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.envres.2011.02.005

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  • Residential Proximity to Major Roads and Preterm Births

    Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    EPIDEMIOLOGY   22 ( 1 )   74 - 80   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: Preterm births cause a large public-health burden, and air pollution is considered to be a potential risk factor. We evaluated the association between proximity to major roads (as an index for air pollution) and preterm births, classified by gestational age and specific clinical manifestations.Methods: Data on parental information and birth outcomes were extracted from the database maintained by the perinatal hospital in Shizuoka, Japan. We restricted the analysis to mothers who delivered liveborn single births from 1997 to 2008 (n = 14,226). Using the geocoded residential information, each birth was classified on its proximity to major roads. We estimated the multivariate-adjusted odds ratios and their 95% confidence intervals (CIs) for the association of proximity to major roads with preterm births, using logistic regression.Results: We found positive associations between proximity to major roads and preterm births at all gestational ages. Living within 200 m increased the risk of births before 37 weeks by 1.5 times (95% CI = 1.2-1.8), birth before 32 weeks by 1.6 times (1.1-2.4), and births before 28 weeks by 1.8 times (1.0-3.2). Proximity specifically increased the risk of preterm births with preterm premature rupture of the membranes and with pregnancy hypertension.Conclusions: This study demonstrates that exposure to traffic-related air pollution increases even the risk of preterm births of less than 30 weeks' gestational age and proposes a possible mechanism.

    DOI: 10.1097/EDE.0b013e3181fe759f

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  • Environmental factors and seasonal influenza onset in Okayama city, Japan: case-crossover study

    Tsuchihashi Y, Yorifuji T, Takao S, Suzuki E, Mori S, Doi H, Tsuda T

    Acta Medica Okayama   65 ( 2 )   97 - 103   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/45268

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  • Multi-level, cross-sectional study of workplace social capital and smoking among Japanese employees

    Etsuji Suzuki, Takeo Fujiwara, Soshi Takao, S. V. Subramanian, Eiji Yamamoto, Ichiro Kawachi

    BMC PUBLIC HEALTH   10   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background: Social capital is hypothesized to be relevant to health promotion, and the association between community social capital and cigarette smoking has been examined. Individual-level social capital has been found to be associated with smoking cessation, but evidence remains sparse on the contextual effect of social capital and smoking. Further, evidence remains sparse on the association between smoking and social capital in the workplace, where people are spending an increasing portion of their daily lives. We examined the association between workplace social capital and smoking status among Japanese private sector employees.Methods: We employed a two-stage stratified random sampling procedure. Of the total of 1,800 subjects in 60 companies, 1,171 (men/women; 834/337) employees (65.1%) were identified from 46 companies in Okayama in 2007. Workplace social capital was assessed in two dimensions; trust and reciprocity. Company-level social capital was based on inquiring about employee perceptions of trust and reciprocity among co-workers, and then aggregating their responses in order to calculate the proportion of workers reporting mistrust and lack of reciprocity. Multilevel logistic regression analysis was conducted using Markov Chain Monte Carlo methods to explore whether individual-and company-level social capital was associated with smoking. Odds ratios (ORs) and 95% credible intervals (CIs) for current smoking were obtained.Results: Overall, 33.3% of the subjects smoked currently. There was no relationship between individual-level mistrust of others and smoking status. By contrast, one-standard deviation change in company-level mistrust was associated with higher odds of smoking (OR: 1.25, 95% CI: 1.06-1.46) even after controlling for individual-level mistrust, sex, age, occupation, educational attainment, alcohol use, physical activity, body mass index, and chronic diseases. No clear associations were found between lack of reciprocity and smoking both at the individual-and company-level.Conclusions: Company-level mistrust is associated with higher likelihood of smoking among Japanese employees, while individual perceptions of mistrust were not associated. The link between lack of reciprocity and smoking was not supported either at the individual-or company-level. Further studies are warranted to examine the possible link between company-level trust and smoking cessation in the Japanese workplace.

    DOI: 10.1186/1471-2458-10-489

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  • Does low workplace social capital have detrimental effect on workers’ health?

    Suzuki E, Takao S, Subramanian SV, Komatsu H, Doi H, Kawachi I

    Social Science & Medicine   70 ( 9 )   1367 - 1372   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.socscimed.2010.01.014

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  • Long-term exposure to methylmercury and its effects on hypertension in Minamata 査読

    Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M

    Environmental Research   110 ( 1 )   40 - 46   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.envres.2009.10.011

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  • Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort 査読

    Etsuji Suzuki, Takashi Yorifuji, Soshi Takao, Hirokazu Komatsu, Masumi Sugiyama, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

    ANNALS OF EPIDEMIOLOGY   19 ( 10 )   732 - 739   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    PURPOSE: To investigate the association between green tea consumption and mortality from all causes, cancer, and cardiovascular disease (CVD) among elderly people.METHODS: In a population-based, prospective cohort study, a total of 14,001 elderly residents (aged 65-84 years), randomly chosen from all 74 municipalities in Shizuoka, Japan, completed questionnaires that included items about frequency of green tea consumption. They were followed for up to 6 years, from December 1999 to March 2006. Consequently, 12,251 subjects were analyzed to estimate the hazard ratios (HRs) for all-cause mortality, cancer, and CVD.RESULTS: Among 64,002 person-years, 1,224 deaths were identified (follow-up rate, 71.6%). The multivariate HRs and 95% confidence intervals (CIs) for CVD mortality compared those who consumed seven or more cups per day with those who consumed less than one cup per day, were 0.24 (0.14-0-40), 0.30 (0.15-0.61), and 0.18 (0.08-0.40) for total participants, men, and women, respectively. Although green tea consumption was not inversely associated with cancer mortality, green tea consumption and colorectal cancer mortality were inversely associated with a moderate dose-response relationship.CONCLUSIONS: Green tea consumption is associated with reduced mortality from all causes and CVD. This study also suggests that green tea Could have protective effects against colorectal cancer. Ann Epidemiol 2009; 19:732-739. (C) 2009 Elsevier Inc. All rights reserved.

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  • Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: A population-based cohort study 査読

    Etsuji Suzuki, Takashi Yorifuji, Kazumune Ueshima, Soshi Takao, Masumi Sugiyama, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

    PREVENTIVE MEDICINE   49 ( 2-3 )   135 - 141   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objective. To investigate the associations between sleep duration and mortality in the elderly by controlling for sleep quality.Method. Data were collected from participants in a cohort study in Shizuoka, Japan. A total of 14,001 elderly residents (aged 65-85 years), randomly chosen from all 74 municipalities in the prefecture. completed questionnaires that evaluated sleep duration, sleep complaints, and the use of hypnotics. Participants were followed from 1999 to 2006. We analyzed 11,395 subjects to estimate the hazard ratios (HR) for mortality from all causes and cardiovascular disease (CVD).Results. With 60,252 person-years, 1004 deaths were identified. While short sleep duration and mortality were not associated, longer sleep duration was associated with higher risk of mortality in both sexes. Compared with those who slept 7 h, the multivariate HR and 95% confidence interval of CVD mortality for those who slept >= 10 h was 1.95 (1.18-3.21) and, for those who slept <= 5 h, it was 1.10 (0.62-1.93). Although no clear association was found between sleep quality and mortality, long sleep duration was associated with higher risk of CVD mortality among those with poor sleep quality.Conclusion. Long sleep duration is associated with higher risk of CVD mortality among the elderly with poor sleep quality. (C) 2009 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ypmed.2009.06.016

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  • Total Mercury Content in Hair and Neurologic Signs Historic Data From Minamata

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    EPIDEMIOLOGY   20 ( 2 )   188 - 193   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: Large-scale methylmercury poisonings have occurred in Japan (Minamata and Niigata) and in Iraq. The current WHO threshold for adult exposure (hair level: 50 mu g/g) was based on evidence from Niigata, which included only acute and severe cases. That study leaves open the possibility of more subtle effects at lower exposure levels.Methods: The Shiranui sea had been contaminated in the 1950s by the discharge of methylmercury from a factory near Minamata.In 1960, the hair mercury content of 1694 residents living on the coastline of the Shiranui sea was measured by researchers from the Kumamoto Prefecture Institute for Health Research. Independently, in 1971, a population-based study to examine neurologic signs was conducted in the Minamata and Goshonoura areas, on the coastline of the Shiranui Sea, and the Ariake area (reference), by researchers at Kumamoto University. We identified 120 residents from exposed areas who were included in both datasets, plus 730 residents of Ariake (an unexposed area) who were also examined for neurologic signs.Results: Hair mercury levels were associated with perioral sensory loss in a dose-response relationship. The adjusted prevalence odds ratios and 95% confidence intervals for perioral sensory loss, compared with the lowest exposure category (0-10 mu g/g), were 4.5 (0.5-44), 9.1 (1.0-83), and 10 (0.9-110), for the dose categories >10 to 20, >20 to 50, and >50 mu g/g, respectively. The prevalence of all neurologic signs was higher in the exposure area than in Ariake.Conclusions: An increased prevalence of neurologic signs, especially perioral sensory loss, was found among residents with hair mercury content below 50 mu g/g.

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  • Impact of Breastfeeding on Body Weight of Preschool Children in a Rural Area of Japan: Population-based Cross-sectional Study 査読

    Hirokazu Komatsu, Takashi Yorifuji, Toshibide Iwase, Ayako Sasaki, Soshi Takao, Hiroyuki Doi

    ACTA MEDICA OKAYAMA   63 ( 1 )   49 - 55   2009年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    To investigate the effect of exclusive breastfeeding on the likelihood of Japanese preschool children being overweight, population-based cross-sectional survey data from M town in Japan were used. Using the population registry of this town, all 616 preschool children were identified, and a self-administered questionnaire was sent to their parents. The exposure variable of interest was exclusive breastfeeding from. birth to 6 months, and the outcome variable of interest was the children being overweight at preschool age. Statistical analyses used included logistic regression and sensitivity analyses. In the final analyses, we included 448 preschool children. Although all point estimates indicated a protective effect, logistic regression analyses showed no significant reduction in being overweight due to exclusive breastfeeding in the unadjusted model (odds ratio (OR)= 0.70, 95% confidence intervals: 0.30-1.64), the model adjusted for birth weight (OR = 0.70, 95% CI: 030-1.63), the model adjusted for child lifestyle (OR = 0.71, 95% CI: 0.30-1.67), or the model adjusted for parental factors (OR=0.46, 95% CI: 0.15-1.37). In sensitivity analyses, point estimates were not significant, but a protective effect was observed. In conclusion, our results suggest that breastfeeding might have a protective effect on Japanese preschool children against being overweight, although statistical significance was not observed due to the limitation of the statistical power of the findings.

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  • Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Morality in Japan: Shizuoka Study 査読

    Takashi Yorifuji, Saori Kashima, Etsuji Suzuki, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    The journal of obstetrics and gynaecology research   19 ( 6 )   S195   2008年11月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/01.ede.0000340088.39958.8b

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  • [Utilization, needs, and related factors for e-learning and its application to education and training in occupational safety and health among enterprises in Japan]. 査読

    Toshiharu Mitsuhashi, Soshi Takao, Akizumi Tsutsumi, Norito Kawakami

    Sangyo eiseigaku zasshi = Journal of occupational health   48 ( 5 )   183 - 91   2006年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    In order to know utilization, needs, and related factors for e-learning and its application to education and training in occupational safety and health (OSH) among enterprises in Japan, a questionnaire survey was conducted of enterprises randomly selected from those with 1,000 or more employees and those with 999 or less (500 for each). Data from 134 (56 and 78, respectively) enterprises were analyzed (response rate, 13%). Among total enterprises, 19% had introduced and 16% planned to introduce e-learning. However, only 7% of larger enterprises and less than 3% of smaller enterprises used e-learning for education and training in OSH. On the other hand, 80-90% of enterprises responded positively to considering the use of e-learning for education and training on various OSH topics for various users. Highly rated merits of e-learning were "can use whenever", "can use anywhere"; and its highly rated obstacles were "cost", "individual PC not available", "insufficient information on efficacy". However, the merit "can monitor training" was significantly associated with the use/plan of e-learning. "Good contents not available" was more frequent among enterprises which used/planned e-learning. The study indicated a greater need for e-learning based OSH education and training, despite a currently low rate of its use. Improvement of e-learning platforms and contents, reduction of cost, and improvement of e-learning infrastructure at work may be needed to facilitate the use of e-learning in OSH.

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  • 職場における管理監督者メンタルヘルス研修前後の知識・態度・行動の変化 査読

    西内 恭子, 高尾 総司, 峰山 幸子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   323 - 323   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 心理社会的職業性ストレスと仕事のパフォーマンス 自記式質問紙による検討 査読

    堤 明純, 川上 憲人, 高尾 総司, 峰山 幸子, 西内 恭子

    産業衛生学雑誌   46 ( 臨増 )   426 - 426   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 管理監督者の傾聴的態度スキルと一般従業員のメンタルヘルスの関連についての検討 査読

    峰山 幸子, 高尾 総司, 西内 恭子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   323 - 323   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職場における管理監督者向けメンタルヘルス基礎研修のRCTによる効果評価 査読

    津田 佳穂, 高尾 総司, 峰山 幸子, 西内 恭子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   322 - 322   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • F305 原因確率とAction・Lnaction・Causal lnference

    津田 敏秀, 大津 忠弘, 高尾 総司, 茂見 潤, 馬場 園明, 三野 善央

    産業衛生学雑誌   44   516 - 516   2002年

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    記述言語:日本語   出版者・発行元:公益社団法人 日本産業衛生学会  

    DOI: 10.1539/sangyoeisei.KJ00003947921

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書籍等出版物

  • 健康管理は従業員にまかせなさい―労務管理によるメンタルヘルス対策の極意

    高尾 総司, 前園 健司, 森 悠太

    保健文化社  2023年7月  ( ISBN:4938435195

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    総ページ数:272  

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  • 疾病を抱える社員の労務管理アドバイス : メンタルヘルス・がん・糖尿病・脳卒中

    馬場, 三紀子, 大嶽, 達哉, 高尾, 総司

    新日本法規出版  2020年9月  ( ISBN:9784788287778

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    総ページ数:4, 276p   記述言語:日本語

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  • 面接シナリオによるメンタルヘルス対応の実務 : ケーススタディ

    高尾, 総司, 森, 悠太, 前園, 健司

    労働新聞社  2020年9月  ( ISBN:9784897618272

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    総ページ数:177p   記述言語:日本語

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  • 社会疫学

    Berkman, Lisa F., 河内, 一郎, Glymour, M. Maria, 高尾, 総司, 藤原, 武男, 近藤, 尚己

    大修館書店  2017年9月  ( ISBN:9784469268294

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    総ページ数:2冊   記述言語:日本語

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  • 完全攻略!もう悩まないストレスチェック制度

    高尾, 総司

    労働新聞社  2016年2月  ( ISBN:9784897615882

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    総ページ数:108p   記述言語:日本語

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  • 健康管理は社員自身にやらせなさい : 労務管理によるメンタルヘルス対策の極意

    高尾, 総司, 岩瀬, 敏秀, 三橋, 利晴, 井家, 克彦

    保健文化社  2014年5月  ( ISBN:9784938435172

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    総ページ数:239p   記述言語:日本語

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  • ソーシャル・キャピタルと健康政策 : 地域で活用するために

    河内, 一郎, 高尾, 総司, Subramanian, S. V., 近藤, 尚己, 白井, こころ, 近藤, 克則

    日本評論社  2013年8月  ( ISBN:9784535586420

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    総ページ数:viii, 455p   記述言語:日本語

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  • Global perspectives on social capital and health

    河内, 一郎, 高尾, 総司, Subramanian, S. V.

    Springer  2013年  ( ISBN:9781461474630

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    総ページ数:x, 349 p.   記述言語:英語

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  • ケースメソッドによる公衆衛生教育 第4版

    篠原出版,東京  2009年 

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  • 職業性ストレスとがん罹患の関連性およびそのメカニズムに関する疫学的研究

    川上, 憲人, 堤, 明純, 津田, 敏秀, 中田, 光紀, 高尾, 総司, 廣川, 空実, 島津, 明人

    川上憲人  2008年5月 

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    総ページ数:175p  

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  • ソーシャル・キャピタルと健康

    河内, 一郎, Subramanian, S. V., Kim, Daniel H, 藤澤, 由和, 高尾, 総司, 濱野, 強

    日本評論社,東京  2008年  ( ISBN:9784535982932

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    総ページ数:217p   記述言語:日本語

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  • 岡山県メタボリックシンドローム改善支援マニュアル I.市町村アプローチ計画策定マニュアル

    岡山県保健福祉部健康対策課,岡山  2007年 

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  • 岡山県メタボリックシンドローム改善支援マニュアル II.市町村向け指導マニュアル

    岡山県保健福祉部健康対策課,岡山  2007年 

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  • ケースメソッドによる公衆衛生教育 第3版

    篠原出版,東京  2006年 

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  • 健康教育・健康管理のレシピ

    南山堂,東京  2005年 

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  • 不平等が健康を損なう

    河内, 一郎, Kennedy, Bruce P., 社会疫学研究会, 西, 信雄, 高尾, 総司, 中山, 健夫

    日本評論社,東京  2004年  ( ISBN:9784535982376

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    総ページ数:ix, 195p   記述言語:日本語

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  • 厚生労働科学研究費補助金健康科学総合研究事業 「行動科学に基づく簡便な生活習慣改善プログラムの開発と効果の検討」 平成15年度研究報告書 主任研究者 足達淑子

    2004年 

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  • 平成14年度中央労働災害防止協会委託 労働安全衛生に関する調査研究報告書

    2003年 

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  • 厚生労働科学研究費補助金健康科学総合研究事業 「行動科学に基づく簡便な生活習慣改善プログラムの開発と効果の検討」 平成14年度研究報告書 主任研究者 足達淑子

    2003年 

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  • 厚生労働省 職場におけるメンタルヘルス対策の事業者等支援事業調査研究報告書 「事業場における精神科医の産業医としての活用に関する調査研究報告書」 平成13年度 中央労働災害防止協会

    2002年 

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▼全件表示

MISC

  • 考察「しごとと健康」 職場におけるLGBT等への対応(2)

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 832 )   39 - 40   2023年10月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 職場におけるLGBT等への対応(1)

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 831 )   33 - 34   2023年9月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • ソーシャル・キャピタルとメンタルヘルス

    高尾 総司

    心と社会   54 ( 3 )   46 - 51   2023年9月

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    記述言語:日本語   出版者・発行元:(公財)日本精神衛生会  

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  • 考察「しごとと健康」 自殺のポストベンション

    高尾 総司, 森 悠太, 前園 健司

    健康管理   ( 830 )   28 - 29   2023年8月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 副業と労働時間管理

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 829 )   43 - 44   2023年7月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 女性のライフステージとメンタルヘルス 就労女性におけるメンタルヘルス

    高尾 総司

    女性心身医学   28 ( 1 )   92 - 92   2023年7月

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    記述言語:日本語   出版者・発行元:(一社)日本女性心身医学会  

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  • 考察「しごとと健康」 アルコール依存症対応

    高尾 総司, 前園 健司, 森 悠太

    健康管理   ( 828 )   40 - 41   2023年6月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 黄色紙と通知文方式

    高尾 総司, 森 悠太, 前園 健司

    健康管理   ( 827 )   37 - 38   2023年5月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 健康相談A/Bコース

    高尾 総司, 森 悠太, 前園 健司

    健康管理   ( 826 )   43 - 44   2023年4月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 コロナ後遺症への対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 825 )   33 - 34   2023年3月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 新型コロナウイルスワクチン接種歴と抗体価との関連

    門脇 知花, 佐々木 綾子, 松本 尚美, 三橋 利晴, 高尾 総司, 頼藤 貴志

    日本衛生学雑誌   78 ( Suppl. )   S194 - S194   2023年3月

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    記述言語:日本語   出版者・発行元:(一社)日本衛生学会  

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  • 考察「しごとと健康」 過重労働エビデンスアップデート2023

    高尾 総司, 森 悠太, 前園 健司

    健康管理   ( 824 )   35 - 36   2023年2月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 健康情報の取扱い

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 823 )   42 - 43   2023年1月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • ラドン温泉入浴習慣と主観的健康の関連性に関する三朝町における横断的研究

    田中歩, 片岡隆浩, 土生裕, 直江翔太, 村上海斗, 藤本有希, 雪峰諒平, 高尾総司, 光延文裕, 頼藤貴志, 山岡聖典

    アイソトープ・放射線研究発表会(Web)   60th   2023年

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  • 「しごとと健康」164 なぜ産業医に言わせたいのか?-魔法?の産業医面談-

    高尾総司, 森悠太, 前園健司

    健康管理   70 ( 11 )   2023年

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  • 新型コロナウイルスワクチン接種歴と抗体価との関連

    門脇知花, 佐々木綾子, 松本尚美, 三橋利晴, 高尾総司, 頼藤貴志

    日本衛生学雑誌(Web)   78 ( Supplement )   2023年

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  • ラドン温泉入浴と健康状態に関する横断研究

    片岡隆浩, 土生裕, 田中歩, 直江翔太, 高尾総司, 光延文裕, 頼藤貴志, 山岡聖典

    日本酸化ストレス学会学術集会プログラム・抄録集   76th   2023年

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  • 岡山市の新型コロナウイルス感染症の各流行期における症状及び重症度の比較に関する記述分析研究

    松尾 瑠美, 松本 尚美, 門脇 知花, 三橋 利晴, 高尾 総司, 頼藤 貴志

    岡山医学会雑誌   134 ( 3 )   160 - 165   2022年12月

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    記述言語:日本語   出版者・発行元:岡山医学会  

    2020年2月1日から2022年3月31日までに岡山市保健所にCOVID-19の発生届があった患者31037名を対象とし、流行期別に第3波~第6波に分け、症状、重症度、死亡割合などについて分析した。結果、症状のうち発熱の割合は各流行期とも約55%前後であった。デルタ株が流行した第5波では、それまでの流行期に比べて発熱や全身倦怠感、関節・筋肉痛、頭痛などの症状が強く、下痢などの消化器症状が比較的多くみられた。オミクロン株が流行した第6波では咽頭痛が50%と多かった。嗅覚・味覚障害は第3波では約7%で、その後は1~3%と低下傾向にあった。各流行期における中等症II以上の割合を年齢層別にみると、第4波までは60~70代で30%以上、80代以上で40%以上と高かったが、その後は低下傾向にあった。60~70代の死亡割合は第3波が最も高く2.1%で、その後は低下傾向にあった。80代以上の死亡割合は、第3・4波に12%前後と高く、第5波に2.3%と低下し、第6波に4.2%とやや上昇していた。

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00175&link_issn=&doc_id=20221208190003&doc_link_id=10.4044%2Fjoma.134.160&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.134.160&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • 考察「しごとと健康」 私傷病休職と育児休業

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 822 )   43 - 44   2022年12月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 在宅勤務に関する諸問題への対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   69 ( 821 )   31 - 32   2022年11月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 考察「しごとと健康」 在宅勤務に関する諸問題への対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 821 )   31 - 32   2022年11月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 原職復帰の原則に懐疑的な方へ 7つの質問

    森 悠太, 前園 健司, 高尾 総司

    健康管理   69 ( 820 )   39 - 40   2022年10月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 考察「しごとと健康」 原職復帰の原則に懐疑的な方へ 7つの質問

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 820 )   39 - 40   2022年10月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • フレイルと障害程度別の要介護認定との関連について 3年間のコホート研究

    萩山 明和, 高尾 総司, 頼藤 貴志, 濱田 全紀, 堅山 佳美, 千田 益生

    The Japanese Journal of Rehabilitation Medicine   59 ( 秋季特別号 )   S480 - S480   2022年10月

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    記述言語:日本語   出版者・発行元:(公社)日本リハビリテーション医学会  

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  • 考察「しごとと健康」 盲点 高ストレス者面接実施後の措置

    高尾 総司, 森 悠太, 前園 健司

    健康管理   69 ( 819 )   37 - 38   2022年9月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 岡山県内における新型コロナウイルス感染症クラスターの発生時期別特徴について

    門脇 知花, 入江 佐織, 高橋 友香里, 薬師寺 泰匡, 高尾 総司, 頼藤 貴志

    岡山医学会雑誌   134 ( 2 )   86 - 91   2022年8月

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    記述言語:日本語   出版者・発行元:岡山医学会  

    県内で2020年10月〜2021年9月に発生したクラスターのうち、医療機関と高齢者施設で発生したものを対象とし、発生時期別に第3波(2020年10月〜2021年3月)、第4波(2021年4月〜6月)、第5波(2021年7月〜9月)に分け、各波の「発生件数」「クラスター発端」「収束までの期間」などについて比較検討した。結果、第3波と第4波では医療機関・高齢者施設とも陽性者数の増加に伴いクラスター発生件数が増加しているのに対して、第5波では陽性者数は増加しているもののクラスター発生件数は医療機関・高齢者施設とも減少していた。クラスター発端については、第3波の医療機関クラスターでは職員発端が多く、高齢者施設では利用者発端が多かった。第4波では医療機関・高齢者施設とも患者・利用発端が多かった。医療機関のクラスターでは第3波に比べて第4波で収束までの期間が長い傾向にあった。2021年5月に総社市の医療機関で発生したクラスターの1事例を提示した。

    DOI: 10.4044/joma.134.86

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  • 岡山県内における新型コロナウイルス感染症クラスターの発生時期別特徴について

    門脇 知花, 入江 佐織, 高橋 友香里, 薬師寺 泰匡, 高尾 総司, 頼藤 貴志

    岡山医学会雑誌   134 ( 2 )   86 - 91   2022年8月

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    記述言語:日本語   出版者・発行元:岡山医学会  

    県内で2020年10月~2021年9月に発生したクラスターのうち、医療機関と高齢者施設で発生したものを対象とし、発生時期別に第3波(2020年10月~2021年3月)、第4波(2021年4月~6月)、第5波(2021年7月~9月)に分け、各波の「発生件数」「クラスター発端」「収束までの期間」などについて比較検討した。結果、第3波と第4波では医療機関・高齢者施設とも陽性者数の増加に伴いクラスター発生件数が増加しているのに対して、第5波では陽性者数は増加しているもののクラスター発生件数は医療機関・高齢者施設とも減少していた。クラスター発端については、第3波の医療機関クラスターでは職員発端が多く、高齢者施設では利用者発端が多かった。第4波では医療機関・高齢者施設とも患者・利用発端が多かった。医療機関のクラスターでは第3波に比べて第4波で収束までの期間が長い傾向にあった。2021年5月に総社市の医療機関で発生したクラスターの1事例を提示した。

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00175&link_issn=&doc_id=20220808080003&doc_link_id=10.4044%2Fjoma.134.86&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.134.86&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • 考察「しごとと健康」 2つの対照的な事例

    高尾 総司, 森 悠太, 前園 健司

    健康管理   69 ( 817 )   40 - 41   2022年7月

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  • 考察「しごとと健康」 サポート窓口による対応 健康管理と労務管理の隙間をなくす

    高尾 総司, 森 悠太, 前園 健司

    健康管理   69 ( 816 )   40 - 41   2022年6月

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  • 健康管理の主体と肥満・喫煙の関連性 岡山県における調査から

    植嶋 一宗, 高尾 総司

    産業衛生学雑誌   64 ( 臨増 )   424 - 424   2022年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 考察「しごとと健康」 ストップ要件の適用 丁寧な考察

    高尾 総司, 森 悠太, 前園 健司

    健康管理   69 ( 815 )   33 - 34   2022年5月

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  • 非同期オンラインツールを用いた産業医に対する指導の試み

    高尾 総司

    産業衛生学雑誌   64 ( 臨増 )   489 - 489   2022年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 考察「しごとと健康」 なぜ産業保健はトラブルと隣り合わせという印象が拭えなくなったか

    高尾 総司, 森 悠太, 前園 健司

    健康管理   69 ( 814 )   33 - 34   2022年4月

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  • 考察「しごとと健康」【再考】人事部門との連携のコツ

    森 悠太, 前園 健司, 高尾 総司

    健康管理   69 ( 813 )   40 - 41   2022年3月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 新型コロナウイルス感染症リスクと在宅勤務

    森 悠太, 前園 健司, 高尾 総司

    健康管理   69 ( 812 )   35 - 36   2022年2月

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  • 考察「しごとと健康」 主治医による復職診断という思考停止

    高尾 総司

    健康管理   69 ( 811 )   33 - 34   2022年1月

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  • 新型コロナウイルスワクチン副反応調査の報告

    松本尚美, 樋口千草, 三橋利晴, 萩谷英大, 高尾総司, 頼藤貴志

    岡山医学会雑誌   134 ( 1 )   35 - 42   2022年

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    記述言語:日本語   出版者・発行元:岡山医学会  

    DOI: 10.4044/joma.134.35

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  • 原職復帰の原則の例外とするための三条件

    高尾総司, 森悠太, 前園健司

    健康管理   69 ( 8 )   2022年

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  • 考察「しごとと健康」【再考】仕事と治療の両立支援

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 810 )   34 - 35   2021年12月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】メンタル不調と懲戒処分

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 809 )   40 - 41   2021年11月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】パワハラグレー対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 808 )   39 - 40   2021年10月

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  • 考察「しごとと健康」【再考】パワハラグレー対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 808 )   39 - 40   2021年10月

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  • 考察「しごとと健康」【再考】療養の段階

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 807 )   38 - 39   2021年9月

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  • 考察「しごとと健康」【再考】療養の段階

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 807 )   38 - 39   2021年9月

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  • 考察「しごとと健康」【再考】復帰基準の考え方

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 806 )   36 - 37   2021年8月

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  • 考察「しごとと健康」【再考】家族の関与の重要性

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 805 )   31 - 32   2021年7月

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  • 考察「しごとと健康」【再考】メンタル対応の大原則・三原則

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 804 )   35 - 36   2021年6月

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  • 考察「しごとと健康」【再考】メンタル対応はなぜ難しいと言われるのか

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 803 )   36 - 37   2021年5月

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  • 考察「しごとと健康」【再考】二つの健康管理

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 802 )   41 - 42   2021年4月

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  • 考察「しごとと健康」 ブルーカラーのホワイトカラー化

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 800 )   34 - 35   2021年2月

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  • 考察「しごとと健康」 従業員との適切な距離感とは

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 799 )   35 - 36   2021年1月

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  • 考察「しごとと健康」 片山組事件とメソッド

    森 悠太, 前園 健司, 高尾 総司

    健康管理   67 ( 798 )   36 - 37   2020年12月

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  • 考察「しごとと健康」 「モジュラー型」メソッド

    森 悠太, 前園 健司, 高尾 総司

    健康管理   67 ( 797 )   37 - 38   2020年11月

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  • 考察「しごとと健康」 治療上出社と判定出社

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 796 )   37 - 38   2020年10月

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  • 「業務的健康管理」によるメンタルヘルス不調者対応 : 産業医選任がない小規模事業場でも対応できる

    森 悠太, 高尾 総司

    安全衛生コンサルタント : 一般社団法人日本労働安全衛生コンサルタント会機関誌   40 ( 136 )   60 - 67   2020年10月

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    記述言語:日本語   出版者・発行元:日本労働安全衛生コンサルタント会  

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  • 在宅ワークで復帰は可能? : 休職者対応の基本的な考え方

    高尾 総司, 森 悠太

    安全スタッフ = 安全・衛生・教育・保険の総合実務誌   ( 2361 )   24 - 28   2020年9月

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    記述言語:日本語   出版者・発行元:労働新聞社  

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  • 慢性統合失調症患者におけるアリピプラゾール単剤治療への切替方法についての検討(多施設コホート研究)

    大林 芳明, 光井 聡, 酒本 真次, 皆尾 望, 吉村 文太, 耕野 敏樹, 矢田 勇慈, 岡久 祐子, 高尾 総司, 来住 由樹, 武田 俊彦, 高木 学, 山田 了士

    精神神経学雑誌   116th ( 2020特別号 )   S426 - S426   2020年9月

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    記述言語:日本語   出版者・発行元:(公社)日本精神神経学会  

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  • AI、データサイエンス、因果推論 産業保健への展望

    鈴木 越治, 三橋 利晴, 山本 倫生, 高尾 総司, 頼藤 貴志, 山本 英二

    産業衛生学雑誌   62 ( 臨増 )   407 - 407   2020年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 健康生成・ストレス対処力SOCと職場のソーシャルキャピタル

    大井 雄一, 堀 大介, 高尾 総司, 室井 慧, 新井 陽, 池田 朝彦, 池田 有, 白木 渚, 高橋 司, 道喜 将太郎, 笹原 信一朗, 松崎 一葉

    産業衛生学雑誌   62 ( 臨増 )   400 - 400   2020年5月

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  • 人事の主体的関与を引き出すメンタルヘルス対応方法の開発と試行

    森 悠太, 高尾 総司

    産業衛生学雑誌   62 ( 臨増 )   526 - 526   2020年5月

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  • 考察「しごとと健康」119 自治体事例の類型

    高尾総司, 森悠太

    健康管理   67 ( 2 )   2020年

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  • 考察「しごとと健康」126 ハイブリッド対応の問題点

    森悠太, 高尾総司, 前園健司

    健康管理   67 ( 9 )   2020年

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  • 考察「しごとと健康」122 産業医役割の原点回帰-面接シナリオによる実現-

    高尾総司, 森悠太

    健康管理   67 ( 5 )   2020年

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  • メンタルヘルス対応困難事例(新型うつを含む)を考える 病名に依存しないメンタルヘルス対応

    高尾 総司

    産業衛生学雑誌   61 ( 臨増 )   204 - 204   2019年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 復職時の産業医意見と人事意見の関係 産業保健活動に関するニーズ調査から

    高尾 総司, 岸本 卓巳, 勝田 吉彰

    産業衛生学雑誌   60 ( 臨増 )   414 - 414   2018年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Relationship between pure-tone audiogram findings and speech perception among older Japanese persons

    Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

    Acta Oto-Laryngologica   138 ( 2 )   140 - 144   2018年2月

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    記述言語:英語   出版者・発行元:Taylor and Francis Ltd  

    Objective: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. Methods: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson’s correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. Results: SP correlated well (r = −0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = −0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). Conclusion: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

    DOI: 10.1080/00016489.2017.1378435

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  • 地域高齢者におけるソーシャル・キャピタルと希死念慮との関連

    野口正行, 小林朋子, 岩瀬敏秀, 鈴木越治, カワチ イチロー, 高尾総司

    日本社会精神医学会プログラム・抄録集   37th   2018年

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  • 高負荷社員のための「公平な」ストレスチェック制度の運用方法の開発と試行

    高尾総司, 岸本卓巳, 野口正行, 勝田吉彰, 梅木佳則, 小島健一, 村本浩, 山本正晴, 川瀬洋平, 西浦千尋

    総合健康推進財団研究報告書   2016   2018年

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  • 健康の社会的決定要因と総合診療 健康の社会的決定要因(ストレス,労働,失業)

    高尾総司

    ジェネラリスト教育コンソーシアム   10   2018年

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  • Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

    Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   39 ( 10 )   2057 - 2069   2017年10月

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    記述言語:英語   出版者・発行元:WILEY  

    Background: Most studies that examined risk factors for wound complications after head and neck reconstruction analyzed various complications collectively. Moreover, they included a wide variety of resection areas and reconstruction materials. To overcome these limitations, both the resection area and reconstruction method were constrained in the present study.
    Methods: Patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled. The outcomes of interest were abscesses, fistulas, and cervical skin flap necrosis.
    Results: Abscesses, fistulas, and cervical skin flap necrosis developed in 19.3%, 11.3%, and 8.2% of 773 patients, respectively. A significant relationship was found between use of an open drain and abscess formation and between a longer operation time and cervical skin flap necrosis.
    Conclusion: Our findings suggest that use of an open drain, cardiovascular disease, and a longer operation time are significant risk factors for abscess formation, fistula formation, and cervical skin flap necrosis, respectively.

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  • メンタルヘルス不調者への仕事本位の対応—特集 メンタルヘルス不調者対応 ; 解説編

    高尾 総司

    月刊人事労務   29 ( 7 )   4 - 17   2017年7月

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    記述言語:日本語   出版者・発行元:日本人事労務研究所  

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  • 産業医活動に対する満足度と肥満・喫煙の関連性

    植嶋 一宗, 高尾 総司

    産業衛生学雑誌   59 ( 臨増 )   396 - 396   2017年5月

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  • 分散事業場における円滑な事例対応のための工夫 事前相談シートの活用について

    友常 祐介, 平岡 晃, 岡部 花枝, 監物 友理, 高尾 総司

    産業衛生学雑誌   59 ( 臨増 )   470 - 470   2017年5月

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  • Social Capital and Suicidal Ideation in Community-Dwelling Older Residents: A Multilevel Analysis of 10,094 Subjects in Japan

    Masayuki Noguchi, Tomoko Kobayashi, Toshihide Iwase, Etsuji Suzuki, Ichiro Kawachi, Soshi Takao

    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY   25 ( 1 )   37 - 47   2017年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective: Social capital, the collective resources of groups including perceptions of trust and reciprocity, is recognized as an important contributor to suicide. We examined the association of individual-and community-level social capital with suicidal ideation after adjusting for social support among older adults living in the community. Methods: In August 2010 we sent questionnaires to all residents aged 65 years and older living in 3 rural municipalities (N = 21,232) in Okayama Prefecture, Japan; 13,919 questionnaires were returned (response rate: 65.6%). The final analysis included 10,094 participants. The outcome variable was suicidal ideation. Exposure variables were individual-level mistrust and lack of reciprocity (level 1), and the aggregated responses of these variables from 35 communities in the municipalities (level 2). Covariates included age, sex, educational attainment, marital status, the number of cohabitants, years of residence, self-rated socioeconomic status, disability, social support, and psychological distress. Multilevel logistic regression analysis was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Results: After adjusting for social support and psychological distress, we found that mistrust and lack of reciprocity were only associated with suicidal ideation at the individual level. Stratified analysis showed that among subjects with psychological distress, mistrust was associated with suicidal ideation at individual (OR: 1.88; 95% CI: 1.42-2.51) and community levels (OR: 1.98; 95% CI: 1.02-3.81). Conclusions: Our findings show that individual-and community-level social capital is a possible protective factor for suicidal ideation, particularly for people with psychological distress.

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  • Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Akira Minoura, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    ONCOLOGY   93 ( 3 )   204 - 212   2017年

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    記述言語:英語   出版者・発行元:KARGER  

    Objective: We aimed to determine the distribution of tumor-associated macrophages (TAMs) in the development of tongue squamous cell carcinoma (SCC) and to elucidate the role of TAMs in the progression of tongue SCC. Methods: The expression of the macrophage markers nitric oxide synthase, Retnla, and mannose receptor 1 in the development of tongue SCC was longitudinally observed using real-time quantitative polymerase chain reaction. Additionally, an immunohistochemical study using an anti-mannose receptor (MR) antibody was performed. Results: The numbers of both of M1 and M2 macrophages in the tongues of mice treated with 4-nitroquinoline-1-oxide (4NQO) were significantly lower compared with those of normal tongues. The cyclo-oxygenase-2 (COX-2) inhibitor did not prevent cancer progression and did not affect the total number of macrophages in the tongues of 4NQO-treated mice. In the immunohistochemical studies, MR staining was observed in lymphangio-endothelium in the subepithelial area of the tongues. The staining intensity of the MR was significantly stronger in the 4NQO-treated mice compared with that in control mice and 4NQO-treated mice treated with the COX-2 inhibitor. Conclusion: TAMs may not contribute to the development of 4NQO-induced tongue SCC. MR expression is associated with the progression of 4NQO-induced tongue SCC. (C) 2017 S. Karger AG, Basel

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  • 扁桃周囲膿瘍における細菌学的検査の役割

    橘 智靖, 折田 頼尚, 高尾 総司, 小河原 悠哉, 松山 祐子, 清水 藍子, 藤澤 郁, 中田 道広, 佐藤 康晴, 西﨑 和則

    日本耳鼻咽喉科学会会報   120 ( 5 )   772 - 773   2017年

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    記述言語:日本語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:一般社団法人 日本耳鼻咽喉科学会  

    DOI: 10.3950/jibiinkoka.120.772

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  • 上司教育による労務管理的メンタルヘルス一次予防

    高尾総司

    日本職業・災害医学会会誌   65   2017年

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  • The role of bacteriological studies in the management of peritonsillar abscess

    Tomoyasu Tachibana, Yorihisa Orita, Soshi Takao, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Iku Abe-Fujisawa, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

    AURIS NASUS LARYNX   43 ( 6 )   648 - 653   2016年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI LTD  

    Objective: Since most patients with peritonsillar abscess (PTA) can be successfully treated with surgical drainage and empirical antibiotic therapy, routine bacteriologic studies for all patients with PTA may be unnecessary. This study tried to evaluate which patients with PTA should certainly undergo bacteriologic studies.
    Methods: Hundred consecutive patients with PTA were treated and underwent culture tests of purulent contents obtained by surgical drainage between April 2008 and December 2013.
    Results: In 62 of the 100 patients, 71 pathogenic bacteria were identified; 61 (86%) were Gram-positive cocci (GPC), 8 (11%) were Gram-negative rods (GNR), and 6 (8%) were anaerobes. Normal flora were isolated in 27 patients, and culture results were negative in 11 patients. Although not significant, primary (without prior antibiotic therapy) case (odds ratio (OR) = 2.19; 95% CI, 0.95-5.05) and laryngeal edema (OR = 2.04; 95% CI, 0.82-5.03) showed a tendency of associations with detection of pathogenic bacteria. After taking into account interactions between smoking habit and laryngeal edema, the covariate-adjusted OR for non-smokers with laryngeal edema was significant and showed a strong relationship (OR = 7.43; 95% confidence interval, 1.05-52.73) compared to non-smokers without laryngeal edema.
    Conclusion: Although empirical antibiotic therapy was effective for most of the PTA patients, bacteriologic studies might be indispensable for the patients with laryngeal edema considering the failure of the first treatments. Particularly, the culture tests may be useful for non-smokers with laryngeal edema. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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  • Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Hiroyuki Hanakawa, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akira Minoura, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    CANCER IMMUNOLOGY IMMUNOTHERAPY   65 ( 11 )   1401 - 1410   2016年11月

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    記述言語:英語   出版者・発行元:SPRINGER  

    The objective of this study was to observe the distribution of regulatory T cells (Tregs) in the development of tongue squamous cell carcinoma (SCC) and to determine the role of Tregs in the progression of tongue SCC. A mouse model of 4-nitroquinoline-1-oxide (4NQO)-induced-tongue SCC was established. The expression of Forkhead box P3 (Foxp3), interleukin 10, transforming growth factor-beta, chemokine CC motif ligands 17, 20, and CC chemokine receptor 4 was determined using real-time quantitative polymerase chain reaction. Foxp3 expression was also analyzed using immunohistochemistry. The results were compared with those of control mice and of 4NQO-treated mice treated with a cyclooxygenase-2 (COX-2) inhibitor. Well to moderately differentiated tongue SCC was induced in all of the experimental mice. The amount of Tregs of the experimental mice was over 10 times as much as control mice at the early stage of tumor progression. COX-2 inhibitor did not prevent the progression of tongue SCC and did not reduce the total amount of Tregs. Tregs function at the early stage of the development of tongue SCC, and it may be effective to suppress Tregs at the early stage of tumor progression for the treatment and/or prevention of tongue SCC.

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  • 特集 現場が主導するメンタルヘルス対策 : 書式活用による業務標準化のメリット

    高尾 総司

    ビジネスガイド   53 ( 12 )   19 - 33   2016年9月

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    記述言語:日本語   出版者・発行元:日本法令  

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  • Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes

    Shinji Sakamoto, Manabu Takaki, Yuko Okahisa, Yutaka Mizuki, Masatoshi Inagaki, Hiroshi Ujike, Toshiharu Mitsuhashi, Soshi Takao, Masashi Ikeda, Yosuke Uchitomi, Nakao Iwata, Norihito Yamada

    JOURNAL OF HUMAN GENETICS   61 ( 4 )   329 - 334   2016年4月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Many patients with schizophrenia have poor clinical and social outcomes. Some risk alleles closely related to the onset of schizophrenia have been reported to be associated with their clinical phenotypes, but the direct relationship between genetic vulnerability to schizophrenia and clinical/social outcomes of schizophrenia, as evaluated by both practical clinical scales and 'real-world' function, has not been investigated. We evaluated the clinical and social outcomes of 455 Japanese patients with schizophrenia by severity of illness according to the Clinical Global Impression-Severity Scale (CGI-S) and social outcomes by social adjustment/maladjustment at 5 years after the first visit. We examined whether 46 single nucleotide polymorphisms (SNPs) selected from a Japanese genome-wide association study of susceptibility to schizophrenia were associated with clinical and social outcomes. We also investigated the polygenic risk scores of 46 SNPs. Allele-wise association analysis detected three SNPs, including rs2623659 in the CUB and Sushi multiple domains-1 (CSMD1) gene, associated with severity of illness at end point. The severity of illness at end point was associated with treatment response, but not with the severity of illness at baseline. Three SNPs, including rs2294424 in the C6orf105 gene, were associated with social outcomes. Point estimates of odds ratios showed positive relationships between polygenic risk scores and clinical/social outcomes; however, the results were not statistically significant. Because these results are exploratory, we need to replicate them with a larger sample in a future study.

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  • ソーシャル・キャピタルと健康経営

    高尾 総司

    心と社会 / 日本精神衛生会 編   47 ( 2 )   87 - 92   2016年

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    記述言語:日本語   出版者・発行元:日本精神衛生会  

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    その他リンク: https://search.jamas.or.jp/link/ui/2016307506

  • 特集 健康日本21(第2次)の初期評価 健康日本21と職場における健康管理

    高尾 総司

    保健師ジャーナル   71 ( 6 )   480 - 484   2015年6月

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    出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1664200184

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  • 記述統計の結果を報告する際の検定の扱いについて CONSORT 2010声明とSTROBE声明を踏まえて

    鈴木 越治, 三橋 利晴, 高尾 総司, 津田 敏秀

    産業衛生学雑誌   57 ( 臨増 )   466 - 466   2015年5月

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  • Social support and suicidal ideation in Japan: are home visits by commissioned welfare volunteers associated with a lower risk of suicidal ideation among elderly people in the community? (vol 49, pg 619, 2014)

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Yoko Kishimoto, Soshi Takao

    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY   50 ( 3 )   505 - 506   2015年3月

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    記述言語:英語   出版者・発行元:SPRINGER HEIDELBERG  

    DOI: 10.1007/s00127-014-0967-0

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  • 事例集 新しい健康日本21へのヒント(13)地域の見守り体制をつくる : 吉備中央町におけるソーシャル・キャピタル育成の試み

    野口 正行, 千田 政子, 伊藤 しおり

    保健師ジャーナル   70 ( 5 )   418 - 422   2014年5月

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    記述言語:日本語   出版者・発行元:医学書院  

    DOI: 10.11477/mf.1664102419

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  • Industrial distributions of severe occupational injuries among workers in Thailand. 国際誌

    Michiyo Yamakawa, Pornchai Sithisarankul, Takashi Yorifuji, Sarunya Hengpraprom, Narin Hiransuthikul, Hiroyuki Doi, Soshi Takao

    Journal of occupational health   55 ( 5 )   415 - 21   2014年

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    記述言語:英語   出版者・発行元:WILEY  

    BACKGROUND: In industrializing countries, occupational safety and health have been affected by globalization. However, a lack of reliable data prevents evaluation of this situation. Therefore, we examined industrial distributions and risks of severe occupational injuries among workers in Thailand, which is one of the few industrializing countries that compiles nationwide data. METHODS: Data on workers who made claims for occupational injuries from 2007 to 2009 were extracted from the Workmen's Compensation Fund records in Thailand. Among 501,334 claimants, we evaluated the industrial distributions of severe occupational injuries (i.e., permanent disability and death). We then examined the associations between industry and those injuries, using proportionate ratios (PRs) between each industrial category and the overall distribution of occupational injuries. RESULTS: The number of workers in manufacturing making claims for severe occupational injuries was the largest among all industrial categories (319,114/501,334 injuries), although the total number of occupational injuries recently declined. Additionally, workers in manufacturing experienced severe occupational injuries more often compared with the overall distribution of occupational injuries. The PRs (95% confidence interval) for manufacturing were 1.17 (1.14-1.20) in men and 1.33 (1.27-1.38) in women. After adjusting for individual characteristics, the results did not substantially change. CONCLUSIONS: Manufacturing seems to have the largest burden of occupational injuries in industrializing countries like Thailand.

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  • 効果的な産業医研修会実施のための産業医意識実態調査-産業医研修会参加とメンタルヘルス実務に対する態度の関連について-

    高尾総司, 岸本卓巳

    産業衛生学雑誌   56   2014年

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  • Type D Personality Is Associated with Psychological Distress and Poor Self-Rated Health among the Elderly: A Population-Based Study in Japan

    Yosuke Kasai, Etsuji Suzuki, Toshihide Iwase, Hiroyuki Doi, Soshi Takao

    PLOS ONE   8 ( 10 )   e77918-e77918   2013年10月

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    記述言語:英語   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    We investigated the association between Type D personality, psychological distress, and self-ratings of poor health in elderly Japanese people. In August 2010, questionnaires were sent to all residents aged >= 65 in three municipalities (n = 21232) in Okayama Prefecture, Japan, and. 13929 questionnaires were returned (response rate: 65.6%). To assess mental and physical health outcomes, we used the Kessler Psychological Distress Scale and a single item question regarding perceived general health. We analyzed 9759 questionnaires to determine odds ratios (ORs) and 95% confidence intervals (CIs) for several health outcomes, adjusting for sex, age, smoking status, frequency of alcohol consumption, overweight status, educational attainment, socioeconomic status, and number of cohabiters. The multiple imputation method was employed for missing data regarding Type D personality. The prevalence of Type D personality in our sample was 46.2%. After adjusting for covariates, we found that participants with Type D personality were at 4-5 times the risk of psychological distress, and twice the risk of poor self-rated health. This association was stronger in participants aged 65-74 years (psychological distress; OR: 5.80, 95% CI: 4.96-6.78, poor self-rated health; OR: 2.84, 95% CI: 2.38-3.38) than in those aged over 75 years (psychological distress; OR: 4.54, 95% CI: 3.96-5.19, poor self-rated health; OR: 2.05, 95% CI: 1.79-2.34). Type D personality is associated with adverse health status among Japanese elderly people in terms of mental and physical risk; therefore, further research into the implications of this personality type is warranted.

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  • 問題発生時におけるルール・業務遂行レベルに基づくメンタルヘルス対応 (特集 メンタルヘルス不調者への対応) -- (解説編)

    高尾 総司

    月刊人事労務   25 ( 9 )   4 - 15   2013年9月

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    記述言語:日本語   出版者・発行元:日本人事労務研究所  

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  • Global perspectives on social capital and health

    Ichiro Kawachi, Soshi Takao, S. V. Subramanian

    Global Perspectives on Social Capital and Health   1 - 349   2013年1月

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    This book is a follow up to Social Capital and Health (2008), edited by Kawachi, Subramanian and Kim. Global Perspectives on Social Capital and Health provides a timely update on emerging topics in a fast-growing field, and features contributions from an outstanding international team of scholars, selected from a diverse range of disciplinary backgrounds including: social epidemiology, medical geography, social psychology, social welfare and gerontology, pediatrics, political science, economics, and medical sociology. The book is organized in three parts: Part 1. Emerging directions in social capital research. This section highlights novel directions in social capital research. These include: a) novel settings for conducting research on social capital (workplaces, schools), b) new approaches for causal inference in social capital (instrumental variable analysis, twin fixed effects designs)
    c) cutting-edge directions for social capital research, including studies of the origins of community social capital, the use of social network analysis to investigate social capital, and novel methods for investigating the link between social capital and crime. Part 2. Social capital and health policy. The three chapters in this section highlight implications of social capital for interventions and health policy. Part 3. Social capital and health in global perspective The four chapters in this section look at research on social capital and health from a global perspective. The authors summarize the empirical studies on social capital and health conducted in each country/region, or each population group
    discuss how the concept of social capital translates across different cultures
    and identify challenges and future directions for research.

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  • Social cohesion and mortality: a survival analysis of older adults in Japan.

    Inoue S, Yorifuji T, Takao S, Doi H, Kawachi I

    Am J Public Health.   103 ( 12 )   e60-e66   2013年

  • 職場のソーシャル・キャピタルと健康に関するレビュー

    鈴木越治, OKSANEN Tuula, VAHTERA Jussi, VAHTERA Jussi, KIVIMAKI Mika, KIVIMAKI Mika, KIVIMAKI Mika, 高尾総司

    産業衛生学雑誌   55   2013年

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  • 「しごとと健康」34 安全衛生管理体制と企業買収

    高尾総司

    健康管理   60 ( 1 )   2013年

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  • 職場におけるソーシャル・キャピタルと健康に関する実証的研究とベンチマークシステムの構築—2011年度(第15回)研究助成「研究要旨」

    小林 朋子, 高尾 総司, 浜田 淳

    Monthly IHEP   ( 214 )   28 - 30   2012年11月

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    記述言語:日本語   出版者・発行元:医療経済研究機構  

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  • 日本とカンボジアの若年者におけるソーシャル・キャピタルと口腔の健康の関係

    古田 美智子, 野中 愛恵, 江國 大輔, 森田 学, 高尾 総司, 山下 喜久

    日本公衆衛生学会総会抄録集   71回   583 - 583   2012年10月

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  • Do bonding and bridging social capital have differential effects on self-rated health? A community based study in Japan

    Toshihide Iwase, Etsuji Suzuki, Takeo Fujiwara, Soshi Takao, Hiroyuki Doi, Ichiro Kawachi

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   66 ( 6 )   557 - 562   2012年6月

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    記述言語:英語   出版者・発行元:BMJ PUBLISHING GROUP  

    Background Few studies have examined the potential difference in the relationship between bonding versus bridging social capital and health outcomes. We sought to examine the association between these different types of social capital and self-rated health in a population-based study.Methods In February 2009, 4000 residents of Okayama City (aged 20-80 y) were randomly selected for a survey on social capital and health. The survey asked about participation in six different types of associations: Parents and Teachers Association, sports clubs, alumni associations, political campaign clubs, citizen's groups and community associations. We distinguished between bonding and bridging social capital by asking participants about their perceived homogeneity (with respect to gender, age and occupation) of the groups they belonged to. ORs and 95% CIs for poor health were calculated.Results Bridging social capital (ie, participation in groups involving people from a diversity of backgrounds) was inversely associated with poor health in both sexes and women appeared to benefit more than men. Compared to those who reported zero participation, high bridging social capital was associated with a reduced odds of poor health (OR 0.25, 95% CI 0.11 to 0.55) in women after controlling for demographic variables, socioeconomic status, smoking habit and overweight. By contrast, bonding social capital was not consistently associated with better health in either gender.Conclusions The present study suggests that bonding and bridging social capital have differential associations with health and that the two forms of social capital need to be distinguished in considering interventions to promote health.

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  • 個人レベルソーシャルキャピタルと主観的不健康 リソースジェネレーターを用いて

    小林 朋子, 岩瀬 敏秀, 三橋 利晴, 高尾 総司, 鈴木 越治

    産業衛生学雑誌   54 ( 臨増 )   503 - 503   2012年5月

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  • 日本人男性労働者における交替勤務と糖尿病の関連 不定期および常時交替勤務の比較

    井家 克彦, 鈴木 越治, 三橋 利晴, 小林 朋子, 高尾 総司

    産業衛生学雑誌   54 ( 臨増 )   444 - 444   2012年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    J-GLOBAL

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  • 母親の労働時間と小児の過体重の関連 追加報告

    三橋 利晴, 鈴木 越治, 高尾 総司, 津田 敏秀, 土居 弘幸

    産業衛生学雑誌   54 ( 臨増 )   362 - 362   2012年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 考察「しごとと健康」 職場における健康情報の管理

    三橋 利晴, 高尾 総司

    健康管理   ( 694 )   42 - 43   2012年4月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • Social capital and self-rated oral health among young people. 国際誌

    Michiko Furuta, Daisuke Ekuni, Soshi Takao, Etsuji Suzuki, Manabu Morita, Ichiro Kawachi

    Community dentistry and oral epidemiology   40 ( 2 )   97 - 104   2012年4月

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    記述言語:英語  

    OBJECTIVES: A few studies have revealed the impact of neighborhood social capital on oral health among young people. We sought to examine the associations of social capital in three settings (families, neighborhoods, and schools) with self-rated oral health among a sample of college students in Japan. METHODS: Cross-sectional survey of 967 students in Okayama University, aged 18 and 19 years, was carried out. Logistic regression was used to examine the associations of poor self-rated oral health with perceptions of social capital, adjusting for self-perceived household income category and oral health behaviors. RESULTS: The prevalence of subjects with poor self-rated oral health was 22%. Adjusted for gender, self-perceived household income category, dental fear, toothbrush frequency, and dental floss use, poor self-rated oral health was significantly associated with lower level of neighborhood trust [odds ratio (OR) 2.22; 95% confidence interval (CI): 1.40-3.54] and lower level of vertical trust in school (OR 1.71; 95% CI: 1.05-2.80). Low informal social control was unexpectedly associated with better oral health (OR 0.54; 95% CI: 0.34-0.85). CONCLUSIONS: The association of social capital with self-rated oral health is not uniform. Higher trust is associated with better oral health, whereas higher informal control in the community is associated with worse oral health.

    DOI: 10.1111/j.1600-0528.2011.00642.x

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  • 考察「しごとと健康」 健康診断・事後措置の問題解決(5)

    高尾 総司, 三橋 利晴

    健康管理   ( 690 )   40 - 41   2011年12月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • メンタルヘルス不調にどう対応すべきか--産業医や企業の先進的な取り組み事例 業務遂行レベルに着目した対応[含 インタビュー]—特集 職場のメンタルヘルス対策--その最新動向と取り組み

    高尾 総司

    Business labor trend = ビジネス・レーバー・トレンド / 労働政策研究・研修機構 編   18 - 21   2011年7月

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    記述言語:日本語   出版者・発行元:労働政策研究・研修機構  

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  • WORKPLACE SOCIAL CAPITAL AND ALL-CAUSE MORTALITY: A PROSPECTIVE COHORT STUDY OF 28,043 PUBLIC SECTOR EMPLOYEES, 2000-2009 査読 国際共著 国際誌

    T. Oksanen, M. Kivimaki, I. Kawachi, S. V. Subramanian, S. Takao, E. Suzuki, A. Kouvonen, J. Pentti, P. Salo, M. Virtanen, J. Vahtera

    AMERICAN JOURNAL OF EPIDEMIOLOGY   173   S50 - S50   2011年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

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  • 交代勤務による糖尿病への影響

    井家 克彦, 鈴木 越治, 三橋 利晴, 小林 朋子, 高尾 総司

    産業衛生学雑誌   53 ( 臨増 )   470 - 470   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 日本の病院におけるソーシャル・ネットワークと看護師の主観的不健康

    岩瀬 敏秀, 三橋 利晴, 高尾 総司, 津田 敏秀, 土居 弘幸

    産業衛生学雑誌   53 ( 臨増 )   500 - 500   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 母親の就業時間と小児の肥満の関連

    三橋 利晴, 鈴木 越治, 高尾 総司, 津田 敏秀

    産業衛生学雑誌   53 ( 臨増 )   552 - 552   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 労働時間と脳・心血管系疾患との関連における睡眠時間の役割についての文献考察

    小林 朋子, 高尾 総司, 土居 弘幸

    産業医学ジャーナル   34 ( 2 )   66 - 71   2011年3月

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    記述言語:日本語   出版者・発行元:産業医学振興財団  

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    その他リンク: http://search.jamas.or.jp/link/ui/2011158538

  • しごとと健康(14)健康診断・事後措置のパラダイムシフト1

    高尾総司, 鈴木越治

    健康管理   ( 5 )   34 - 35   2011年

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  • Does Social Capital Promote Physical Activity? A Population-Based Study in Japan

    Kazumune Ueshima, Takeo Fujiwara, Soshi Takao, Etsuji Suzuki, Toshihide Iwase, Hiroyuki Doi, S. V. Subramanian, Ichiro Kawachi

    PLOS ONE   5 ( 8 )   2010年8月

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    記述言語:英語   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: To examine the association between individual-level social capital and physical activity.Methodology/Principal Findings: In February 2009, data were collected in a population-based cross-sectional survey in Okayama city, Japan. A cluster-sampling approach was used to randomly select 4,000 residents from 20 school districts. A total of 2260 questionnaires were returned (response rate: 57.4%). Individual-level social capital was assessed by an item inquiring about perceived trust of others in the community (cognitive dimension of social capital) categorized as low trust (43.0%), mid trust (38.6%), and high trust (17.3%), as well as participation in voluntary groups (structural dimension of social capital), which further distinguished between bonding (8.9%) and bridging (27.1%) social capital. Using logistic regression, we calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for physical inactivity associated with each domain of social capital. Multiple imputation method was employed for missing data. Among total participants, 68.8% were physically active and 28.9% were inactive. Higher trust was associated with a significantly lower odds of physical inactivity (OR = 0.58, 95% CI = 0.42-0.79) compared with low trust. Both bridging and bonding social capital were marginally significantly associated with lower odds of physical inactivity (bridging, OR = 0.79, 95% CI = 0.62-1.00; bonding, OR = 0.71, 95% CI = 0.48-1.03) compared with lack of structural social capital.Conclusions/Significance: Low individual-level social capital, especially lower trust of others in the community, was associated with physical inactivity among Japanese adults.

    DOI: 10.1371/journal.pone.0012135

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  • MULTILEVEL MODELS FROM TWO DISTINCTIVE DEFINITIONS OF AGGREGATED VARIABLES: SELF-INCLUSION AND SELF-EXCLUSION PROCEDURES 査読 国際共著 国際誌

    E. Suzuki, E. Yamamoto, S. Takao, I. Kawachi, S. V. Subramanian

    AMERICAN JOURNAL OF EPIDEMIOLOGY   171   S139 - S139   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

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  • WORKPLACE SOCIAL CAPITAL AND SMOKING AMONG JAPANESE PRIVATE SECTOR EMPLOYEES 査読 国際共著 国際誌

    E. Suzuki, T. Fujiwara, S. Takao, S. V. Subramanian, E. Yamamoto, I. Kawachi

    AMERICAN JOURNAL OF EPIDEMIOLOGY   171   S13 - S13   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

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  • 企業の健康管理体制と実施状況の関連 サンプリング方法による相違

    井家 克彦, 三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   611 - 611   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 岡山県における企業の健康管理体制と従業員による客観的評価

    小林 朋子, 岩瀬 敏秀, 三橋 利晴, 植嶋 一宗, 井家 克彦, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   612 - 612   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 日本の職場における安全衛生の取り組みと従業員の主観的不健康 岡山県働き盛りの健康支援のための実態調査

    岩瀬 敏秀, 三橋 利晴, 植嶋 一宗, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   613 - 613   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 産業医選任の有無と肥満と喫煙の関連性 ランダムサンプル群とコンビニエントサンプル群における対比

    植嶋 一宗, 岩瀬 敏秀, 三橋 利晴, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   614 - 614   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職場における安全衛生の取り組みと従業員の主観的健康 岡山県働き盛りの健康支援のための実態調査

    高尾 総司, 鈴木 越治, 三橋 利晴, 岩瀬 敏秀, 植嶋 一宗, 井家 克彦, 小林 朋子, 土居 弘幸

    産業衛生学雑誌   52 ( 臨増 )   612 - 612   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 企業の安全衛生管理について取り組みと従業員のBMIと喫煙割合の関連 岡山県働き盛りの健康支援のための実態調査

    三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   613 - 613   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Physical Activity and Mortality Risk in the Japanese Elderly A Cohort Study

    Kazumune Ueshima, Kazuko Ishikawa-Takata, Takashi Yorifuji, Etsuji Suzuki, Saori Kashima, Soshi Takao, Masumi Sugiyama, Toshiki Ohta, Hiroyuki Doi

    AMERICAN JOURNAL OF PREVENTIVE MEDICINE   38 ( 4 )   410 - 418   2010年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Background: Physical activity recommendations for older adults with poor health needs to be understood.Purpose: This study aims to examine the association between the frequency of physical activity and mortality among a sample of elderly subjects, most of whom were under treatment for pre-existing disease.Methods: Data on the frequency of leisure-time physical activity, walking for transportation, and non-exercise physical activity were obtained from a population-based cohort study in Shizuoka, Japan. Of the randomly selected 22,200 residents aged 65-84 years, 10,385 subjects were followed from 1999 to 2006 and analyzed. Hazard ratios (HRs) and 95% CIs were obtained for all-cause; cardiovascular disease (CVD); and cancer mortality, after adjusting for covariates such as preexisting disease(s) A subgroup analysis that was restricted to subjects under treatment for preexisting disease(s) at baseline was further conducted. Data were collected between 1999 and 2006, and all analyses were conducted in 2008 and 2009.Results: Every physical activity was associated with a reduced risk of all-cause and CVD mortality, among not only the total sample but even those under treatment. The HRs for CVD mortality among participants with 5 or more days of non-exercise physical activity per week for the total sample and those with pre-existing disease(s) were 038 (95% CI=0.22, 0 55) and 0.35 (95% CI=0.24, 052), respectively, compared with no non-exercise physical activity. The association between physical activity and cancer mortality was not clearConclusions: This study suggests a protective effect of physical activity on all-cause and CVD mortality among Japanese elderly people with pre-existing disease (Am J Prev Med 2010;38(4) 410-418) (C) 2010 American Journal of Preventive Medicine

    DOI: 10.1016/j.amepre.2009.12.033

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  • Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan

    Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Hiroyuki Doi, Masumi Sugiyama, Kazuko Ishikawa-Takata, Toshiki Ohta

    OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   67 ( 2 )   111 - 117   2010年2月

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    記述言語:英語   出版者・発行元:BMJ PUBLISHING GROUP  

    Objectives The number of studies investigating the health effects of long-term exposure to air pollution is increasing, however, most studies have been conducted in Western countries. The health status of Asian populations may be different to that of Western populations and may, therefore, respond differently to air pollution exposure. Therefore, we evaluated the health effects of long-term exposure to traffic-related air pollution in Shizuoka, Japan.Methods Individual data were extracted from participants of an ongoing cohort study. A total of 14 001 older residents, who were randomly chosen from all 74 municipalities of Shizuoka, completed questionnaires and were followed from December 1999 to March 2006. Individual nitrogen dioxide exposure data, as an index for traffic-related exposure, were modelled using a land use regression model. We assigned participants an estimated concentration of nitrogen dioxide exposure during 2000-2006. We then estimated the adjusted HR and their Cl for a 10 mu g/m(3) increase in exposure to nitrogen dioxide for all-cause or cause-specific mortality.Results The adjusted HR for all-cause mortality was 1.02 (95% Cl 0.96 to 1.08). Regarding cause-specific mortality, the adjusted HR for cardiopulmonary mortality was 1.16 (95% Cl 1.06 to 1.26); in particular the adjusted HR for ischaemic heart disease mortality was 1.27 (95% Cl 1.02 to 1.58) and for pulmonary disease mortality it was 1.19 (95% Cl 1.02 to 1.38). Furthermore, among non-smokers, a 10 mu g/m(3) increase in nitrogen dioxide was associated with a higher risk for lung cancer mortality (HR 1.30, 95% Cl 0.85 to 1.93).Conclusion Long-term exposure to traffic-related air pollution, indexed by nitrogen dioxide concentration, increases the risk of cardiopulmonary mortality, even in a population with a relatively low body mass index and increases the risk of lung cancer mortality in nonsmokers.

    DOI: 10.1136/oem.2008.045542

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  • Is There Any Association between TV Viewing and Obesity in Preschool Children in Japan?

    SASAKI A

    Acta Med Okayama   64 ( 2 )   137 - 142   2010年

  • しごとと健康(9)復職の三要件

    高尾総司, 鈴木越治

    健康管理   ( 12 )   34 - 35   2010年

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  • しごとと健康(1)二つの健康管理

    高尾総司, 鈴木越治

    健康管理   ( 4 )   42 - 43   2010年

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  • ソーシャル・キャピタルと健康に関する調査 リソースジェネレータ結果記述

    三橋 利晴, 岩瀬 敏秀, 高尾 総司, 浜田 淳, 松岡 宏明, 中瀬 克己, 則安 俊昭

    日本公衆衛生学会総会抄録集   68回   239 - 239   2009年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • ソーシャル・キャピタルと健康に関する調査

    岩瀬 敏秀, 三橋 利晴, 高尾 総司, 松岡 宏明, 中瀬 克己, 則安 俊昭, 土居 弘幸

    日本公衆衛生学会総会抄録集   68回   238 - 238   2009年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • Green tea consumption and mortality among Japanese elderly: a population-based cohort study 査読 国際誌

    E. Suzuki, T. Yorifuji, S. Takao, H. Komatsu, M. Sugiyama, H. Doi

    American Journal of Epidemiology   169 ( Suppl 11 )   S83 - S83   2009年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)  

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  • 岡山県の企業における健康管理と従業員の主観的健康

    三橋 利晴, 高尾 総司, 土居 弘幸

    産業衛生学雑誌   51 ( 臨増 )   453 - 453   2009年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職場におけるリスクマネジメントに基づく過重労働対策の構築

    高尾 総司, 鈴木 越治, 神里 英吾, 三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 土居 弘幸

    産業衛生学雑誌   51 ( 臨増 )   639 - 639   2009年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Total hair mercury content and neurological signs in Minamata and neighboring communities.

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    Epidemiology   in press   2009年

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  • Minamata Disease: Catastrophic Poisoning due to a failed public health response

    Tsuda T, Yorifuji T, Takao S, Miyai M, Babazono A

    Journal of Public Health Policy   30 ( 1 )   54 - 67   2009年

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    記述言語:英語   出版者・発行元:PALGRAVE MACMILLAN LTD  

    We present the history of Minamata disease in a chronological order from the public health point of view. Because the appropriate public health response - to investigate and control the outbreak - as set out in the Food Sanitation Act was not conducted, no one knew how many became ill following the outbreak. Exposure could not be stopped. In our discussion, we offer two reasons as to why the Japanese public health agencies did not apply the Act: social circumstances in the 1950s and 1960s that placed emphasis on industrial development, and the Japanese medical community's lack of knowledge about the Act. The history of Minamata disease shows us the consequences when public health responses are not implemented. Minamata disease should be an invaluable lesson for future public health responses.

    DOI: 10.1057/jphp.2008.30

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  • Work-based Social Networks and Health Status among Japanese Employees.

    Suzuki E, Takao S, Subramanian SV, Doi H, Kawachi I

    J Epidemiol Community Health   63   692 - 696   2009年

  • Policy Implications of Social Capital for the Japanese Social Security System

    Jun Hamada, Soshi Takao

    ACTA MEDICA OKAYAMA   62 ( 5 )   275 - 283   2008年10月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We discuss the concept of social capital, which has received much attention recently. Social capital is important for the following 2 key reasons: (1) a highly democratic polity and a strong economic performance that attaches great importance to the public good can be achieved on the basis of high social capital; and (2) social capital can effect health status in the human population, and widening of income inequality harms human health through the erosion of social capital. In addition, there are 3 political implications of social capital for Japanese society: (1) social capital has implications for the political decision of whether Japanese society should adopt a "medium burden for medium welfare" or a "low burden for small welfare" model together with the concept of social overhead capital; (2) reciprocity, which is one of the primary components of social capital, is similar to the philosophy underlying the health care system of Japan; (3) Japanese society needs to change from a society that emphasizes the relationships between its members to a society that is open to outsiders and has sufficient opportunities.

    DOI: 10.18926/AMO/30971

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  • 企業の健康管理方針と従業員の主観的健康およびBMIの関連

    三橋 利晴, 高尾 総司, 土居 弘幸

    日本公衆衛生学会総会抄録集   67回   625 - 625   2008年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • Income Inequality and Population Health : Recent Clues Concerning Pathways and Mechanisms(Symposium B)

    河内 一郎, 藤澤 由和, 高尾 総司

    保健医療社会学論集   18 ( 2 )   29 - 35   2008年

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    記述言語:英語   出版者・発行元:日本保健医療社会学会  

    Income inequality has been implicated as a determinant of population health. Empirical evidence suggests that higher levels of income inequality are associated with worse health outcomes in the population. The pathways linking income inequality to population health remain to be established. However, recent findings from economics provide some clues concerning the mechanisms by which the distribution of income may influence health status. According to one theory, higher levels of income inequality may increase the frequency of invidious social comparisons and heighten the sense of relative deprivation. Recent empirical studies suggest that higher degrees of relative deprivation, as quantified by the Yitzhaki Index, is associated with increased risks of morbidity, mortality, and stress-related health behaviors. A separate theory suggests that increased income inequality erodes the sense of trust and cooperation, and reduces the ability of societies to undertake collective action, such as financing social goods. Recent evidence from experimental economics, using game theory, appears to corroborate this theory. Empirical studies in Japan so far have failed to demonstrate an association between income distribution and population health. On the other hand, it may be too early to conclude that income inequality does not matter for the health of Japanese because of the continuing increases in income inequality between geographic areas of the country, as well as other trends such growing educational inequalities, and the widening disparity in working conditions between full-time workers and part-time, temporary, and contingent workers.

    DOI: 10.18918/jshms.18.2_29

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  • Long-term exposure to methylmercury and neurological signs in Minamata and its neighboring communities: a population-based study

    Yorifuji T, Tsuda T, Takao S, Harada M

    Epidemiology   19 ( 1 )   1 - 2   2008年

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  • 職域における適正飲酒プログラムとは?

    高尾総司

    肥満と糖尿病   7 ( 4 )   583 - 585   2008年

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  • 職場におけるリスクマネジメントに基づく健診事後措置プログラムの開発と評価-2症例の試行結果の報告-

    高尾総司, 鈴木越治, 神里英吾, 小松裕和, 植嶋一宗, 岩瀬敏秀, 土居弘幸

    日本産業衛生学会講演集(CD-ROM)   81st   2008年

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  • 日本人の健康--アメリカにおける教訓から何を学ぶべきか[含 英語文] (特集 健康格差と保健医療政策)

    河内 一郎, 藤澤 由和, 高尾 総司

    保健医療科学   56 ( 2 )   114 - 121   2007年6月

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    記述言語:日本語   出版者・発行元:国立保健医療科学院  

    記事種別: 翻訳

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  • Effects of an education program for stress reduction on supervisor knowledge, attitudes, and behavior in the workplace: A randomized controlled trial

    Kyoko Nishiuchi, Akizumi Tsutsumi, Soshi Takao, Sachiko Mineyama, Norito Kawakami

    JOURNAL OF OCCUPATIONAL HEALTH   49 ( 3 )   190 - 198   2007年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Supervisors at work play a large role in stress management at the workplace. Providing supervisors with necessary information and useful skills might be one effective approach that will lead to stress reduction. However, very few studies have investigated the effect of supervisor education by using a rigorous study design. In a randomized controlled trial, we tried to clarify how an education program for stress reduction influences supervisor knowledge, attitudes, and behavior concerning stress management. The subjects were 46 supervisors of an old, established sake brewery manufacturer of 301 employees. The supervisors were assigned to either the intervention group (24 supervisors) or the control group (22 supervisors). We conducted a single-session education program that included the guidelines for worker mental health promotion to the intervention group. The education program was composed of a basic education lecture and active listening training. The effects of this program on supervisor knowledge, attitudes, and behavior were measured using an original, self-administered questionnaire. The intervention effect was tested by examining an interaction effect between groups and time (before education, three and six months after education). The education favorably affected supervisor knowledge (F=7.92; p=.001). As for behavior, the intervention effect was marginally statistically significant (F=2.51; p=.088). For the attitude score, however, there were no beneficial effects. In conclusion, the provision of necessary information and useful skills to supervisors seems to improve supervisor knowledge and behavior regarding stress management at the workplace for at least six months.

    DOI: 10.1539/joh.49.190

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  • Supervisors’ attitudes and skills for active listening with regard to job stress and psychological stress reactions among subordinate workers.

    Mineyama S, Tsutsumi A, Takao S, Nishiuchi K, Kawakami N

    J Occup Health   49 ( 2 )   81 - 87   2007年3月

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  • 職場における適正飲酒の行動介入プログラムの開発と評価

    高尾総司

    日本アルコール関連問題学会雑誌   9   101 - 108   2007年

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    記述言語:日本語   出版者・発行元:日本アルコール関連問題学会  

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  • 職場における適正飲酒の行動介入プログラムの開発と評価

    高尾 総司

    日本アルコール関連問題学会雑誌 9   108 - 111   2007年

  • Effects of the job stress education for supervisors on psychological distress and job performance among their immediate subordinates: A supervisor-based randomized controlled trial

    Soshi Takao, Akizumi Tsutsumi, Kyoko Nishiuchi, Sachiko Mineyama, Norito Kawakami

    Journal of Occupational Health   48 ( 6 )   494 - 503   2006年11月

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    記述言語:英語  

    As job stress is now one of the biggest health-related problems in the workplace, several education programs for supervisors have been conducted to reduce job stress. We conducted a supervisor-based randomized controlled trial to evaluate the effects of an education program on their subordinates' psychological distress and job performance. The subjects were 301 employees (46 supervisors and 255 subordinates) in a Japanese sake brewery. First, we randomly allocated supervisors to the education group (24 supervisors) and the waiting-list group (22 supervisors). Then, for the allocated supervisors we introduced a single-session, 60-min education program according to the guidelines for employee mental health promotion along with training that provided consulting skills combined with role-playing exercises. We conducted pre- and post-intervention (after 3 months) surveys for all subordinates to examine psychological distress and job performance. We defined the intervention group as those subordinates whose immediate supervisors received the education, and the control group was defined as those subordinates whose supervisors did not. To evaluate the effects, we employed a repeated measures analysis of variance (ANOVA). Overall, the intervention effects (time x group) were not significant for psychological distress or job performance among both male (p=0.456 and 0.252) and female (p=0.714 and 0.106) subordinates. However, young male subordinates engaged in white-collar occupations showed significant intervention effects for psychological distress (p=0.012) and job performance (p=0.029). In conclusion, our study indicated a possible beneficial effect of supervisor education on the psychological distress and job performance of subordinates. This effect may vary according to specific groups.

    DOI: 10.1539/joh.48.494

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  • わが国の企業におけるeラーニングとこれによる労働安全衛生教育の利用状況、ニーズおよび関連要因

    三橋 利晴, 高尾 総司, 堤 明純, 川上 憲人

    産業衛生学雑誌   48 ( 5 )   183 - 191   2006年9月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    わが国の企業におけるeラーニングとこれによる労働安全衛生教育の利用状況、ニーズおよびその促進・阻害要因を明らかにするために、従業員1,000人以上と同999人以下の企業それぞれから500社を抽出し、質問票による調査を実施し、有効回答した合計134社(回答率13%、企業規模それぞれ56社、78社)のデータを分析した。全体で19%の企業がeラーニングを導入済み、さらに16%の企業が導入を検討中であった。しかしeラーニングによる労働安全衛生教育の実施は従業員1,000人以上の企業でも7%、999人以下の企業では3%未満と低かった。一方eラーニングによる労働安全衛生教育についてはどの対象者、コンテンツでも8〜9割の企業が受講させることを考えると回答していた。eラーニングの利点としては「いつでも受講できる」、「どこからでも受講できる」が、導入の問題点としては「コスト」、「パソコンが1人に1台ずつない」、「学習効果が不明確」であった。しかしeラーニングの導入済みあるいは検討中には、「受講状況が把握できる」が有意な関連を示した。「優良なコンテンツが得られない」という問題点は、eラーニング導入済み・検討中の企業に多かった。eラーニングによる労働安全衛生教育はまだ導入している企業は少ないが、そのニーズは高い。eラーニングおよびこれによる労働安全衛生教育の推進のために、eラーニングのシステムおよびコンテンツの改善、導入コストの低減、企業のeラーニング導入インフラの改善が必要と考えた。(著者抄録)

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  • 特集 加重労働による健康被害を防止するために--『やらねばならない事』と『やらなくてもよい事』をズバっと整理する

    高尾 総司

    よぼういがく   36   1 - 52   2006年6月

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    記述言語:日本語   出版者・発行元:日本予防医学協会  

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  • Young epidemiologists' attitude towards Personal Data Protection

    G Kobashi, T Hoshuyama, K Ohta, H Sugimori, Oki, I, H Kanda, M Naito, S Takao, A Tamakoshi

    JOURNAL OF EPIDEMIOLOGY   16 ( 2 )   90 - 92   2006年3月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    DOI: 10.2188/jea.16.90

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  • Effects of web-based supervisor training on job stressors and psychological distress among workers: A workplace-based randomized controlled trial

    N Kawakami, S Takao, Y Kobayashi, A Tsutsumi

    JOURNAL OF OCCUPATIONAL HEALTH   48 ( 1 )   28 - 34   2006年1月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Using workplaces as a unit for randomization, a randomized controlled trial was conducted to determine the effects of web-based supervisor training on the subject of worksite mental health on job stressors, supervisor support and psychological distress among subordinate workers. A total of eight workplaces of a sales and service company were randomly assigned to either training workplaces or non-training workplaces. Supervisors (n=23) at the training workplaces participated in web-based self-learning training on worksite mental health; supervisors (n=23) at the nontraining workplaces did not. A total of 81 subordinate workers under the trained supervisors (the intervention group) and 108 subordinate workers under the nontrained supervisors (the control group) completed the Brief Job Stress Questionnaire (BJSQ) at baseline and at a three-month follow-up. No significant intervention effect was observed for any scale of the BJSQ measuring job stressors, supervisor or coworker support, or psychological distress among subordinate workers (p &gt; 0.05). The item score of work autonomy changed very little in the intervention group, while it decreased in the control group during the follow-up period, yielding a significant intervention effect (p=0.02). The item score for a friendly atmosphere in the workplace increased in the intervention group, while the score remained stable in the control group, yielding a significant intervention effect (p=0.02). While the present study failed to show any clear effect of the webbased training of supervisors on reduction of job stressors, it may be useful for maintaining worker autonomy and improving the friendliness of the worksite atmosphere.

    DOI: 10.1539/joh.48.28

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  • 適正飲酒プログラムの開発と試行.

    高尾総司

    日本アルコール精神医学雑誌   13,3-9?   2006年

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  • 上司の傾聴的態度と部下に認知される仕事の特徴とストレス反応

    峰山 幸子, 堤 明純, 高尾 総司, 西内 恭子, 川上 憲人

    産業ストレス研究   13 ( 1 )   66 - 66   2005年12月

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    記述言語:日本語   出版者・発行元:日本産業ストレス学会  

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  • Effects of web-based supervisor training on supervisor support and psychological distress among workers: A randomized controlled trial

    N Kawakami, Y Kobayashi, S Takao, A Tsutsumi

    PREVENTIVE MEDICINE   41 ( 2 )   471 - 478   2005年8月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Background. A randomized controlled trial was conducted to determine the effects of web-based supervisor training on worksite mental health on supervisor support and psychological distress among subordinate workers.
    Methods. Section chiefs in a computer engineering company were randomly assigned to either a training group (n = 9) or a non-training group (n = 7). The section chiefs in the training group participated in web-based self-learning training on worksite mental health. A total of 92 subordinate workers under the trained section chiefs (the intervention group) and 84 subordinate workers under the untrained section chiefs (the control group) completed a questionnaire at baseline and a 3-month follow-up.
    Results. The score of supervisor support greatly decreased in the control group during the follow-up period, and the score changed very little in the intervention group, with a significant intervention effect (P = 0.032). This pattern was more pronounced for one particular item dealing with the extent to which a supervisor listens to personal problems of subordinate workers (the intervention effect, P = 0.012). No intervention effect was observed for the score measuring co-worker support, psychological distress, or other job stressors among subordinate workers (P &gt; 0.05).
    Conclusions. It is suggested that the web-based training of supervisors on worksite mental health is useful in improving, or at least maintaining, supervisor support among subordinate workers. (c) 2005 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ypmed.2005.01.001

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  • Effects of a supervisory education for positive mental health in the workplace: A quasi-experimental study

    A Tsutsumi, S Takao, S Mineyama, K Nishiuchi, H Komatsu, N Kawakami

    JOURNAL OF OCCUPATIONAL HEALTH   47 ( 3 )   226 - 235   2005年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Single-session supervisory education was developed in conjunction with the Japanese national guidelines for the promotion of employee mental health. Totally 267 voluntary supervisors in a prefectural office were presented with comprehensive information on the role they had to fulfill to promote mental health in the workplace. Totally 864 office employees (53%) were evaluated to determine whether education had had an effect on their psychological distress and job performance. The findings from the departments in which more than one-third of the supervisors had attended education were compared to those from the departments in which no more than one-third of the supervisors had attended education. Three months after the education, the levels of psychological distress and, to a lesser extent, self-reported job performance improved among employees in the departments in which at least one-third of the supervisors attended the education compared to those from departments with lower attendance rates of the supervisors. For the psychological outcome, the positive educational effect was supported by statistically significant interaction terms between time and department category with adjustment for the confounders. Favorable changes were noted among supervisors who received the education in knowledge, attitude, and behavior regarding mental health practices. The behavioral changes were related to decreasing workplace problems and referral of employees to the liaison off ice and associated medical institutions. Despite several limitations, the findings suggest that providing supervisors with appropriate information has a positive effect on employee psychological well-being.

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  • D220 eラーニングによる労働安全衛生教育に関するニーズ・課題調査

    三橋 利晴, 高尾 総司, 川上 憲人, 堤 明純

    産業衛生学雑誌   47 ( 0 )   2005年4月

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    記述言語:日本語   出版者・発行元:公益社団法人日本産業衛生学会  

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  • P3023 職場における適正飲酒の行動介入プログラムの開発と評価 : 無作為化比較試験の途中経過

    高尾 総司, 三橋 利晴, 川上 憲人, 山津 幸司, 足達 淑子

    産業衛生学雑誌   47 ( 0 )   810 - 810   2005年4月

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    記述言語:日本語   出版者・発行元:公益社団法人 日本産業衛生学会  

    DOI: 10.1539/sangyoeisei.KJ00003804440

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  • Clostridium perfringens foodborne outbreak due to braised chop suey supplied by chafing dish

    H Ochiai, T Ohtsu, T Tsuda, H Kagawa, T Kawashita, S Takao, A Tsutsumi, N Kawakami

    ACTA MEDICA OKAYAMA   59 ( 1 )   27 - 32   2005年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    On February 13, 2002, a public health center in Hiroshima Prefecture, Japan, was notified that many individuals living at the Japan Maritime Self-Defence Force base had symptoms resembling those of food poisoning. Self-administered questionnaires requesting information regarding meal consumption and symptoms were distributed to all 281 members at the base. A case of the illness was defined as a member who had had watery or mucousy stool, or loose stool with abdominal cramps, more than twice a day after consuming dinner on February 12. Control of the illness was defined as a member with no symptoms. The dinner on February 12 was significantly associated with the illness (Mantel-Haenszel odds ratio: 3.59, 95% confidence interval: 1.06-12.20). A case-control study showed that, among the food supplied at dinner on February 12, the braised chop suey was significantly associated with the illness (odds ratio: 12.30, 95% confidence interval: 1.90-521.00). The braised chop suey had been stored in a chafing dish. An environmental investigation indicated that Clostridium perfringens (C. perfringens) in the chafing dish proliferated under an inappropriate heat-retention temperature, and the contaminated braised chop suey could have caused the food poisoning. This study demonstrated that the recommended heat-retention temperature (over 65 degreesC) should be confirmed thoroughly.

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  • 「社会疫学(Social Epidemiogy)の集い」のまとめ-第63回公衆衛生学会自由集会より-

    高尾総司

    日本健康教育学会ニュースレター   42,1-2   2005年

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  • 人を対象とした黒豆エキス含有クエン酸飲料の健康増進効果の評価

    落合裕隆, 谷口敏代, 児玉とも江, 藤原恭子, 高尾総司, 川上憲人

    日本公衆衛生学会総会抄録集   63rd   864   2004年10月

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  • ウエルシュ菌による食中毒アウトブレイク事例についての疫学調査

    落合裕隆, 大津忠弘, 香川治子, 河下寿昭, 津田敏秀, 高尾総司, 堤明純, 中瀬克己, 川上憲人

    日本衛生学雑誌   59 ( 2 )   146   2004年3月

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  • 小学校で発生した麻疹集団感染事例

    大津忠弘, 万代素子, 二宮忠矢, 松下明, 高尾総司, 落合裕隆, 津田敏秀, 中瀬克己

    日本衛生学雑誌   59 ( 2 )   145   2004年3月

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  • What expectations do young Japanese epidemiologists have for the future of epidemiology? A questionnaire survey of members of the young epidemiologists society for discussing the future of epidemiology.

    Gen Kobashi, Tsutomu Hoshuyama, Hiroki Sugimori, Izumi Oki, Takashi Kadowaki, Hideyuki Kanda, Tetsuya Otani, Motoki Iwasaki, Mariko Naito, Soshi Takao

    Journal of epidemiology   14 ( 2 )   69 - 71   2004年3月

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  • Eラーニングによる管理監督者向けメンタルヘルス教育の部下のストレス軽減に対する効果 無作為化比較試験

    川上 憲人, 小林 由佳, 高尾 総司, 堤 明純

    産業衛生学雑誌   46 ( 臨増 )   325 - 325   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職位と身体活動量

    高尾総司, 川上憲人

    産業医学ジャーナル   2004年

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  • Occupational class and physical activity among Japanese employees

    S Takao, N Kawakami, T Ohtsu

    SOCIAL SCIENCE & MEDICINE   57 ( 12 )   2281 - 2289   2003年12月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined the distribution of physical activity among different occupations in Japan. A questionnaire was sent to full-time employees at nine companies in Japan between 1996 and 1998, with an average response rate of 85.2%. Data from 20,654 respondents (17,637 male and 3017 female) were analyzed. We classified the occupations into eight groups according to the International Standard Classification of Occupations (1988). Daily energy expenditure, weekly physical activity, and monthly leisure-time physical activity (LTPA) were measured using a physical activity questionnaire and some additional questions. In males, LTPA was significantly different among occupations, with clerks having greater physical activity than managers and blue-collar workers (P&lt;0.001). The pattern was similar even after adjusting for education, age, and working hours. In females, the difference among occupations was not clear. The distribution of LTPA among occupations exhibits a "barrel-shape" in Japan. It was higher for intermediate class occupations such as clerks, which was in agreement with a lower coronary heart disease mortality observed in intermediate class occupations among Japanese male employees. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0277-9536(03)00134-5

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  • 福山市における麻疹流行と予防接種実施状況について 第1報・その1

    吉井健哲, 大津忠弘, 田中知徳, 高尾総司, 落合裕隆, 谷原真一, 津田敏秀, 中瀬克己

    日本公衆衛生学会総会抄録集   62nd   818   2003年10月

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  • 福山市における麻疹流行と予防接種実施状況について 第1報・その2

    大津忠弘, 吉井健哲, 田中知徳, 高尾総司, 落合裕隆, 谷原真一, 津田敏秀, 中瀬克己

    日本公衆衛生学会総会抄録集   62nd   818   2003年10月

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  • 職業性ストレスの職場平均と職場内格差が労働者の抑うつに与える影響 : マルチレベル分析

    川上 憲人, 堤 明純, 高尾 総司, 原谷 隆史

    産業衛生学雑誌 = Journal of occupational health   45   263 - 263   2003年3月

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  • 職業がんとイニシエーター・プロモーター

    津田 敏秀, 大津 忠弘, 高尾 総司, 茂見 潤, 馬場園 明, 三野 善央

    産業衛生学雑誌 = Journal of occupational health   45   603 - 603   2003年3月

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  • P329禁煙支援・事例報告 その1

    高尾 総司, 大津 忠弘, 太田 充彦, 茂見 潤, 津田 敏秀, 堤 明純, 三野 善央, 川上 憲人

    産業衛生学雑誌   44 ( 0 )   689 - 689   2002年3月

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    記述言語:日本語   出版者・発行元:公益社団法人 日本産業衛生学会  

    DOI: 10.1539/sangyoeisei.KJ00003948091

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  • カラーを用いた健康教育の可能性

    高尾 総司

    日本健康教育学会NEWSLETTER   30,1-2   2002年

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  • 禁煙支援・事例報告 その2

    大津忠弘, 高尾総司, 太田充彦, 茂見潤, 津田敏秀, 堤明純, 三野善央, 川上憲人

    産業衛生学雑誌   44   2002年

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  • 職場のメンタルヘルス-産業医の有効的活用-

    高尾総司

    日本健康教育学会NEWSLETTER   26,1-2   2001年

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  • 喫煙とメンタルヘルスとの関連について-職域における調査より-

    大津忠弘, 三野善央, 茂見 潤, 太田充彦, 高尾総司, 津田敏秀, 安田誠史, 馬場園 明, 山本英二, 青山英康

    健康開発   2001年

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  • 嘱託産業医の楽しみ-臨床医から紹介状をいただいた事例-

    高尾総司

    産業医活動報告集   2001年

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  • 腸管出血性大腸菌O157感染者における菌陰性化に要する期間についての検討

    高尾 総司

    岡山醫學會雜誌   112 ( 3 )   75 - 84   2000年8月

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    記述言語:日本語   出版者・発行元:岡山医学会  

    In June 1997, an outbreak of enterohemorrhagic Escherichia coli O157 occurred at a hospital of Okayama City, Japan. E. coli O157 was isolated from 86 patients (40 males and 46 females). Ages ranged from 14 to 96 years old with a mean of 53 years old. All the infected patients (59 asymptomatic carriers) were investigated in this study. The median duration of shedding (from starting therapy), among the 83 patients who received antimicrobial therapy, was 6 days. This result has paticular importance for taking appropriate measures during outbreaks among adults who have other diseases. Other factors (age,sex,etc) that might have affected the duration of shedding were aiso investigated, but were not found to be influential. Among the infected patients, elderly people, females and patients who had other diseases became symptomatic, and in paticular, patients who had severe malignancy became symptomatic. All asymptomatic carriers received antimicrobial therapy and no newly affected cases and no side effects among those patients were observed. these results indicate that antimicrobial therapy for asymptomatic carriers in facilities that have a large number of susceptible people is useful.

    CiNii Article

    CiNii Books

    J-GLOBAL

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    その他リンク: http://ousar.lib.okayama-u.ac.jp/13670

  • 地球における産業保健指導の展開

    高尾 総司, 工藤 葉子, 山本 裕美, 清龍 聡, 石田 高男, 青山 英康

    産業衛生学雑誌 = Journal of occupational health   42   194 - 194   2000年3月

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  • O-157感染者における便中菌陰性化に要する期間

    高尾 総司, 中瀬 克己, 新部 譲, 大津 忠弘, 米井 敏郎, 岸本 卓巳

    日本公衆衛生学会総会抄録集   58回   680 - 680   1999年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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▼全件表示

共同研究・競争的資金等の研究

  • 人工知能を活用したメンタル不調者に対する「画期的・包括的」復帰判定システムの開発

    研究課題/領域番号:24K13481  2024年04月 - 2027年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    高尾 総司, 頼藤 貴志, 宮道 力, 道喜 将太郎

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    資金種別:競争的資金

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

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  • 人工知能を活用したメンタル休職者に対する復職判定面談支援システムの開発

    研究課題/領域番号:21K10446  2021年04月 - 2024年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    高尾 総司, 頼藤 貴志

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    産業医機能の強化が期待されている。なかでもメンタルヘルス不調者への対応は大きな課題である。かかる課題について、就業規則等の労務管理にもとづく対応(業務的対応)と疾患治療による対応(医療的対応)を明確に区別して論理的一貫性のもとに再整理し、人事担当者が主体的に活用できる、療養中および復職判定のための手順と様式などのツールを整えた。しかしながら、これらのツールがあっても、なお、それぞれの会社における対応の独自性差異は無視できないほどに大きいままであるという課題は残されている。
    本研究では、人工知能を活用することで、産業医等の産業保健スタッフのみならず人事担当者が、メンタル不調者の復職判定面談などを実施する際の標準化された支援システム構築を行うことを目的に実施した。
    既存の産業医意見書、対応事例のテキストデータを用いて、最新の自然言語処理技術のモデルを用いて、復職判定を行うモデルを作成した。復職判定を行うモデルでは、初回相談時のテキストデータから、1年以内に復職可能か否かについて的中率(=accuracy)は0.86、AUCは0.95を示した。また、同モデルにおいて復職確率を各ケースごとに計算しそれを平均した結果は、復職までの期間が長くなるほど、値が大きくなる結果となり、一定の妥当性を示した。
    併行して、次年度以降、事例対応に関するテキストデータの提供を依頼することのできる企業を、協力機関とするために、研究概要の説明会を実施した。

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  • 地域・職域連携による橋渡し型ソーシャル・キャピタル醸成の評価に関する基礎的研究

    研究課題/領域番号:16K09098  2016年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    高尾 総司

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    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    「地域・職域連携の指標」として、一般化信頼に加えて、「村内」と「他市町村」の人への信頼の「ギャップ(不一致)」を考えた。具体的には、「一般的には信頼するのに、他市町村の人は信頼しない」というような回答が相当する。この「ギャップ」を曝露として、年齢、性別、主観的SES(Socioeconomic Status)、一般化信頼を調整した、主観的不健康(poor SRH; Self-rated health)およびK6を用いた心理的苦痛(K6>13)の、オッズ比と95%信頼区間は、それぞれ2.63(1.04-6.61)、2.50(0.59-10.56)であった。

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  • 職場のソーシャル・キャピタル醸成を目的とした介入評価および発展的活用の基盤整備

    研究課題/領域番号:25460802  2013年04月 - 2016年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    高尾 総司, 谷原 真一, 浜田 淳

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    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    本研究では、企業における運動イベントの機会を介入とみなし、ソーシャル・キャピタル(SC)が醸成されるかどうかを評価した。なお、対照群の設定が困難であったことから、デザイン上の工夫を行い、擬似的に比較を行った。結果の概要は、天井効果により運動イベントへの参加に伴う明確なSC醸成は観察できなかった。基盤整備に関しては、フィンランドの公務員コホートとのデータ・ハーモナイズ等について研究者間で意見交換した。

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  • ソーシャル・キャピタルを用いたメタボ対策等行政施策評価に関する実証的研究

    研究課題/領域番号:21790582  2009年 - 2011年

    日本学術振興会  科学研究費助成事業  若手研究(B)

    高尾 総司, 谷原 真一, 中谷 友樹, 浜田 淳

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    配分額:3770000円 ( 直接経費:2900000円 、 間接経費:870000円 )

    特定保健指導のような保健施策の効果評価は容易でない。本研究は、ソーシャル・キャピタル(SC)を指標とした施策評価を目的とした。既存データ解析から、SCを結合型と橋渡し型に分けて測定する意義が示唆された。横断調査の結果、愛育委員等による声かけが有意に希死念慮を減少させることが示唆され、地域における声かけを行う小規模な介入を予定したが、東日本大震災に伴う計画の遅れから、企業における運動介入評価を実施した。

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  • ミクロデータを用いた健康水準の地理的格差に関する実証的解析

    研究課題/領域番号:20300297  2008年 - 2010年

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    中谷 友樹, 松田 亮三, 藤澤 由和, 濱野 強, 高尾 総司, 埴淵 知哉

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    配分額:17420000円 ( 直接経費:13400000円 、 間接経費:4020000円 )

    本研究は、地理情報システムや空間統計学的解析、マルチレベル分析、ジオデモグラフィクスなどの地理的分析方法論を、個人を単位としたミクロデータ資料に適用し、日本の大都市圏に存在する近隣地区(町丁字)レベルの健康の地理的格差の実態把握とこれを既定する要因の解明を目的とした。その結果、所得水準などの社会経済的水準の居住者構成のみならず、ソーシャル・キャピタルや安全性、歩きやすさなど居住地域の社会・建造環境も健康の地理的格差の形成に寄与しており、健康水準は大都市圏の微細な居住地帯(社会地区)分化と関連して構造化されていることが明らかとなった。所得水準などで把握される貧困・剥奪の集中を減じる対応とともに、健康に寄与する環境づくりの重要性が示唆された。

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  • 急性アルコール中毒防止のための若年者向け適正飲酒プログラムの開発および効果評価

    研究課題/領域番号:17790385  2005年 - 2007年

    日本学術振興会  科学研究費助成事業  若手研究(B)

    高尾 総司

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    配分額:2500000円 ( 直接経費:2500000円 )

    急性アルコール中毒防止のための若年者向け適正飲酒プログラムの開発および効果評価を目的として、若年者(大学生等)向けの飲酒プログラムのレビュー、若年者がイッキ飲みに至る社会的、個人的要因を明らかにするための小規模な疫学調査、プログラムの試作・試行、等を実施した。
    1.若年者向けの既存の飲酒に対する介入方法として、Harvard University School of Public Healthにおいて実施されたCollege Alcohol Study(CAS)などを参考に検討した。CASでは、大学キャンパス内や近隣における飲酒関連ポリシーの厳格化(例;学生寮での飲酒禁止、近隣居酒屋での飲み放題提供の禁止)などが中心であり、基本的には本プログラムの趣旨には合いにくいものであった。
    2.大学生を対象に若年者がイッキ飲みに至る要因を明らかにするための疫学調査を実施した。調査前に大学生・大学院生を対象に要因の絞り込みを行うためにインタビューを実施したが、外部要因として「部活の(後輩に飲ませる)先輩」が挙げられるなど、本人への介入だけでは対処しにくい点もあった。調査結果として、これまで研究者らが対象としてきた中高年男性とは大きく異なる特性が明らかとなった。特に、中高年男性においては、飲酒量などの面において周囲から問題飲酒の予備群であろうと指摘を受ける当該対象者自身に、いくらかでも自身の飲酒を改善したい、改善しようという認識があったのに対し、若年者においては、本プログラムが対象とするような危険な飲酒の予備群(binge drinkingのあるもの、など)と考えられる対象者には、そもそも飲酒を改善したいとの認識が少なかった。
    3.したがって、中高年男性に対するプログラムでは飲酒のプラス面に焦点をあてることで希望による対象者募集が可能であったが、若年者に対するプログラムでは、募集することが容易ではなく、プログラムの試作に基づき、試行を実施したが、CASのような強制的な方法との併用により提供する必要性もあると考えられた。

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  • 職業性ストレスとがん罹患の関連性およびそのメカニズムに関する疫学的研究

    研究課題/領域番号:16390170  2004年 - 2007年

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    川上 憲人, 堤 明純, 島津 明人, 廣川 空美, 高尾 総司, 津田 敏秀, 中田 光紀

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    配分額:15130000円 ( 直接経費:14500000円 、 間接経費:630000円 )

    本研究では、職業性ストレスとがん罹患との関連性とそのメカニズムを明らかにすることを目的として、2つの前向きコホート研究(既存コホートデータと新規コホート)および職業性ストレスとがん罹患の媒介要因(免疫機能、抗酸化能などの生理指標および食事等のがん関連保健行動)との関係についての小規模な追跡研究を実施した。
    特に本研究では以下の3点を検討した。(1)2大職業性ストレス理論である「要求度-コントロール-社会的支援モデル」および「努カ-報酬不均衡モデル」に基づく職業性ストレスと全がんの罹患(および部位別のがん罹患)との関連性、(2)これ以外の職場の社会心理的な要因とがん罹患との関連性、(3)職業性ストレスとがん関連の生理指標(免疫機能および抗酸化能マーカー)および保健行動(喫煙、飲酒、栄養)との関連性。
    結果として、職業性ストレスは全がんの罹患リスクを増加させる可能性があることが示唆された。そのメカニズムの一部として、職業性ストレスによるDNA酸化があると考えられた。一方、食事や生活習慣は、職業性ストレスとがん罹患をつなぐ媒介変数としては大きな役割を果たしていないと推測された。

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  • ITを用いた耐糖能異常者に対する効果的健康教育法の開発およびその効果評価

    研究課題/領域番号:14770169  2002年 - 2004年

    日本学術振興会  科学研究費助成事業  若手研究(B)

    高尾 総司

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    配分額:2600000円 ( 直接経費:2600000円 )

    ITを用いた耐糖能異常者に対する効果的な健康教育法の開発および効果評価を目的として,(1)健康教育法のレビュー,(2)webページを用いたコンテンツの試作,(3)試作コンテンツを用いたIT健康教育法の試行,を実施した.
    (1)これまでの健康教育法の内容の中心は,(1)食事,(2)運動,(3)減量,(4)飲酒の4領域であった.(1)〜(3)については,完成度の高い教材がそろっており,そのまま活用可能であった.しかし,(4)については質の高い教材が見あたらず,新たに飲酒に関するコンテンツ作成行った.
    (2)双方向性の特徴を活かし,知識を提供するだけでなく,記録表を送信したり,参加者同士が意見交換したりできるwebページの試作を行った.しかし,webページへのアクセスをユーザーIDとパスワードで制限したとしても,サーバー内に保管した個人情報を悪意のある第三者に悪用されることを防ぐこと等が技術的に困難であり,このため試作したコンテンツを公開しての試行は見送った.
    (3)いつでもweb化できるよう意識してコンテンツ制作を行ったが,試行においては,紙ベースの教材,又は電子メール(添付ファイル)を用いて行った.今回は,飲酒量をコントロールするためのコンテンツを無作為化比較試験のデザインで効果評価した.対象は企業に勤務する社員121名(8社)であり,割付は個人単位ではなく,5名程度のグループ単位で行った.10名を除外し,111名(介入群56名,対照群55名)についてrepeated measures ANOVAで解析を行った.介入群の1日当たりの飲酒量は純アルコール64.3gから57.3gに,対照群も54.6gから46.8gに有意(群内(介入前後)F値8.3(p=0.005))に減少した.interaction項はF値0.02(p=0.883)であり,有意な介入効果を認めなかった.

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  • 一般住民の精神健康に関する社会・心理・生理・分子遺伝疫学的研究

    研究課題/領域番号:13470082  2001年 - 2003年

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    川上 憲人, 大津 忠弘, 津田 敏秀, 堤 明純, 尾崎 紀夫, 高尾 総司, 三野 善央

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    配分額:13500000円 ( 直接経費:13500000円 )

    平成13〜14年度には、調査票日本語版の訳語の確認と本調査用面接用プログラム(CAPI)の準備、面接員トレーニングの実施、データの収集とクリーニングを行った。岡山市住民から無作為に抽出したサンプル(1607名)に対して調査依頼し、27名の面接員が最終的に925名に面接を実施した(転居、死亡など調査対象外の者を除く回収率66%)。岡山市におけるDSM-IVおよびICD-10診断基準による主要な精神障害の有病率では、大うつ病(うつ病)、特定の恐怖症、アルコール乱用が比較的多く、うつ病(DSM-IV大うつ病、ICD-10うつ病エピソード)はこれまでに7〜8%の者が、過去12ヶ月間に2.5-2.6%の者がこれを経験していた。平成15年7月3〜10日には世界精神保健調査研究者会議(フランス)に出席し、面接調査データの予備的な解析結果を報告し、解析計画について専門家のレビューを受けるとともに、研究打ち合わせを行った。
    平成15年度には、上記面接調査への回答者から精神障害該当者及び非該当者(1/3の確率で選ばれた者)からそれぞれ採血および生理心理学的調査の対象者合計260名を選び、調査への参加を依頼し、同意した者について採血と生理心理学的測定を実施した。この調査は岡山大学医学部ヒトゲノム・遺伝子解析研究倫理審査委員会で承認された手続きにより書面で同意を得た上で実施された。全血サンプルは一時岡山大学に凍結保存した後、藤田保健衛生大に搬送され、遺伝マーカーの測定を行った。精神障害および自殺行動に影響する社会心理的要因の解析、社会機能およびQOLを含む社会心理的要因の解析、職業性因子の解析を実施した。また遺伝マーカーおよび生理学的要因と精神障害との関連性を解析した。

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