2021/12/13 更新

写真a

タカオ ソウシ
高尾 総司
TAKAO Soshi
所属
医歯薬学域 准教授
職名
准教授
ホームページ
外部リンク

学位

  • 博士(医学) ( 岡山大学 )

研究キーワード

  • Epidemiology

  • 疫学

研究分野

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

 

論文

  • Emergency Dispatches for Suicide Attempts During the COVID-19 Outbreak in Okayama, Japan: A Descriptive Epidemiological Study.

    Hiroshi Habu, Soshi Takao, Ryohei Fujimoto, Hiromichi Naito, Atsunori Nakao, Takashi Yorifuji

    Journal of epidemiology   31 ( 9 )   511 - 517   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Hardships associated with the ongoing coronavirus disease 2019 (COVID-19) pandemic can affect mental health, potentially leading to increased risk of suicide. We examined the relationship between the COVID-19 outbreak and suicide attempts in Okayama, Japan using information from emergency dispatches. METHODS: This was a descriptive epidemiological study. We collected information on emergency dispatches in Okayama City and Kibichuo from March to August in 2018, 2019, and 2020 (n = 47,770 cases). We compared emergency dispatches and their demographic characteristics, especially focusing on suicide attempts, during these 3 years. RESULTS: The number of emergency dispatches in 2020 decreased compared with the previous 2 years, while the number and proportion of emergency dispatches related to suicide attempts increased. This increase was more pronounced among women and those aged 25-49 years. Among women aged 25-49 years, there was a cumulative total of 43 suicide attempts in 2018 and 2019 and 73 suicide attempts in 2020. CONCLUSIONS: The number and proportion of emergency dispatches related to suicide attempts increased in 2020 compared with the previous 2 years, especially among women and those aged 25-49 years. This increase may be partly explained by hardships, such as economic losses or reduced social ties, during the COVID-19 outbreak.

    DOI: 10.2188/jea.JE20210066

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  • Subjective Evaluation of Balance by the Dizziness Handicap Inventory Does Not Predict Fall Risk in Older Adults Visiting Otolaryngology Clinics. 国際誌

    Iku Abe-Fujisawa, Yukihide Maeda, Soshi Takao, Shin Kariya, Kazunori Nishizaki

    The Annals of otology, rhinology, and laryngology   130 ( 9 )   990 - 995   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Subjective symptoms of dizziness in older adults are affected not only by objective data such as postural balance, but also by complex psychological factors. Published data analyzing how simultaneous evaluations of both objective and subjective assessments of balance can predict fall risk remain lacking. This study examined how fall risk can be predicted based on both objective data for balance and hearing and subjective symptoms of dizziness among older adults visiting otolaryngology clinics. METHODS: Medical charts of 76 patients ≥65 years old with dizziness/vertigo who visited the otolaryngology clinic were reviewed. Objective data were evaluated by postural balance (posturographic data with eyes open and closed, and one-leg standing test), spontaneous nystagmus, and mean hearing levels. Subjective handicap associated with dizziness/vertigo was assessed using the Dizziness Handicap Inventory (DHI). Subjective mental status of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Information on history (cardiovascular diseases) and fall accidents within the preceding year was collected using an in-house interview sheet. RESULTS: Objective data on postural balance did not correlate with subjective symptoms on DHI or HADS (P > .05, Pearson's correlation coefficient). Adjusted logistic regression modeling with the outcome of incident falls revealed that poor postural balance significantly predicted fall risk (P < .05; 4.9 [1.4-16.8] per 10-cm2 increment). Nystagmus tended to be associated with fall risk. In contrast, DHI score did not predict fall risk (P = .43; 1.0 [0.9-1.03]). Receiver operating characteristic analysis proposed a cut-off for postural sway with eyes closed >6.1 cm2 as optimal to predict falls in patients with nystagmus (AUC, 0.74; 95% confidence interval, 0.48-0.997). CONCLUSION: Poor postural balance is associated with increased fall risk after adjusting for subjective symptoms in older adults at otolaryngology clinics. Conversely, the self-perceived dizziness handicap of DHI score is an insufficient tool to evaluate their fall risk.

    DOI: 10.1177/0003489420987972

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  • Percutaneous Cryoablation of Lower Limb Soft-Tissue Venous Malformations: Preliminary Results of Long-Term Efficacy. 国際誌

    Hiroyasu Fujiwara, Takao Hiraki, Yusuke Matsui, Mayu Uka, Koji Tomita, Toshihiro Iguchi, Jun Sakurai, Takao Soshi, Hideo Gobara, Susumu Kanazawa

    Cardiovascular and interventional radiology   44 ( 9 )   1485 - 1490   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To retrospectively evaluate long-term efficacy of percutaneous cryoablation for lower limb soft-tissue venous malformations. MATERIALS AND METHODS: Nine patients (mean age, 36.6 years) with lower limb soft-tissue venous malformations were included. Cryoablation was performed percutaneously using an argon-based system. Adverse events (AE) using the Common Terminology Criteria for AEs version 4.0 were evaluated. The visual analog scale (VAS) scores and lesion volumes measured on magnetic resonance imaging were also evaluated at 12 months and 5-6 years. RESULTS: Technical success (i.e., complete coverage of the lesion by an iceball) was achieved in eight of the nine patients. All patients developed a total of 14 grade 1 or 2 adverse events. The mean (± standard deviation) VAS score was 6.0 (± 1.7) before therapy, whereas it was 0.14 (± 0.27) at 12 months and 0.97 (± 1.3) at 5-6 years (58-78 months). Complete pain relief was obtained in 6 and 5 patients at 12 months and 5-6 years, respectively. The median lesion volume was 2.49 mL before therapy, whereas it was 0.26 mL at 12 months and 0.35 mL at 5-6 years. CONCLUSION: Percutaneous cryoablation of lower limb soft-tissue venous malformations achieved considerable pain relief and lesion shrinkage for 5-6 years in this small preliminary study. LEVEL OF EVIDENCE: Level 4, Case Series.

    DOI: 10.1007/s00270-021-02876-4

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  • PD-L1 expression in tongue squamous cell carcinoma.

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   52 - 59   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This large-scale case study aimed to analyze tongue squamous cell carcinomas (SCCs) and evaluate the correlation between PD-L1 expression and clinical prognosis. So far, this study is the largest case study on PD-L1 expression in tongue SCCs. METHODS: This is a case-control study that analyzed 121 tongue SCCs. Paraffin-embedded sections and clinical data were obtained retrospectively and immunohistochemistry with PD-L1 was performed. RESULTS: 11.6% contained ≥ 50% of PD-L1-positive cells, 57.1% of these cases had a poor prognosis with nodal metastasis. Among cases of T1/2 primary lesions with nodal metastasis, cases of high PD-L1 expression had a significantly shorter disease-free survival than cases of no PD-L1 expression (p = 0.018). The hazard ratio for high PD-L1 expression was 3.21 (95 per cent CI, 1.26-8.72) compared with no PD-L1 expression after adjusting for other factors. CONCLUSIONS: These data indicate that PD-L1 upregulation in tongue SCCs is associated with a more advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors might hence constitute potential adjuvant therapy for tongue SCCs with PD-L1 upregulation.

    DOI: 10.1007/s00795-020-00261-7

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  • Correction to: PD-L1 expression in tongue squamous cell carcinoma.

    Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

    Medical molecular morphology   54 ( 1 )   68 - 68   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In the original publication of the article an affiliation should be added to the first author “Naoki Akisada” as given below:5Departments of Otolaryngology Head and Neck Surgery,Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama 700‑8558,Japan

    DOI: 10.1007/s00795-020-00270-6

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  • The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study 国際誌

    Yuji Yada, Kohei Kitagawa, Shinji Sakamoto, Atsushi Ozawa, Akihiro Nakada, Hiroko Kashiwagi, Yuko Okahisa, Soshi Takao, Manabu Takaki, Yoshiki Kishi, Norihito Yamada

    ACTA PSYCHIATRICA SCANDINAVICA   143 ( 3 )   227 - 237   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Objective There is no report that statistically evaluates the therapeutic reference (350-600 ng/ml) and adverse drug reaction (ADR) range (>1000 ng/ml) of clozapine (CLZ) recommended by the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) consensus guidelines in an isolated and large sampling study.Methods We administered CLZ to 131 Japanese patients with treatment-resistant schizophrenia in a multicenter cross-sectional study. Plasma CLZ concentrations were assayed by high-performance liquid chromatography using trough sampling. The Brief Psychiatric Rating Scale (BPRS) and severe dose-dependent ADR (sedation, myoclonus, and seizures) were analyzed statistically after adjusting for possible confounders.Results The daily CLZ dosage showed a moderately positive relationship with the plasma concentration (r = 0.49, p 0.001). Every 100 ng/ml increase in plasma CLZ concentration improved the total BPRS score 1.95% (95% CI: 0.89-3.01, p 0.001) and the odds ratio (OR) 1.38 (95% CI: 1.14-1.66, p = 0.001) for BPRS response. Compared with concentrations below 350 ng/ml CLZ, 350-600 ng/ml (11.12%; 95% CI: 2.52-19.72, p = 0.012) and 600-1000 ng/ml (11.05%; 95% CI: 2.40-19.71, p = 0.013) showed significant improvement in the total BPRS score. Dosages above 1000 ng/ml showed greater improvement (25.36%; 95% CI: 13.08-37.64, p 0.001) of the total BPRS score but more severe ADRs than dosages below 1000 ng/ml (OR: 31.72; 95% CI: 1.04-968.81, p = 0.048).Conclusion The AGNP therapeutic reference range (350-600 ng/ml) is useful, and a dose above 1000 ng/ml is potentially more effective but carries the risk of severe ADRs in the central nervous system.

    DOI: 10.1111/acps.13264

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  • The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study. 国際誌

    Yuji Yada, Kohei Kitagawa, Shinji Sakamoto, Atsushi Ozawa, Akihiro Nakada, Hiroko Kashiwagi, Yuko Okahisa, Soshi Takao, Manabu Takaki, Yoshiki Kishi, Norihito Yamada

    Acta psychiatrica Scandinavica   143 ( 3 )   227 - 237   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    OBJECTIVE: There is no report that statistically evaluates the therapeutic reference (350-600 ng/ml) and adverse drug reaction (ADR) range (>1000 ng/ml) of clozapine (CLZ) recommended by the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) consensus guidelines in an isolated and large sampling study. METHODS: We administered CLZ to 131 Japanese patients with treatment-resistant schizophrenia in a multicenter cross-sectional study. Plasma CLZ concentrations were assayed by high-performance liquid chromatography using trough sampling. The Brief Psychiatric Rating Scale (BPRS) and severe dose-dependent ADR (sedation, myoclonus, and seizures) were analyzed statistically after adjusting for possible confounders. RESULTS: The daily CLZ dosage showed a moderately positive relationship with the plasma concentration (r = 0.49, p < 0.001). Every 100 ng/ml increase in plasma CLZ concentration improved the total BPRS score 1.95% (95% CI: 0.89-3.01, p < 0.001) and the odds ratio (OR) 1.38 (95% CI: 1.14-1.66, p = 0.001) for BPRS response. Compared with concentrations below 350 ng/ml CLZ, 350-600 ng/ml (11.12%; 95% CI: 2.52-19.72, p = 0.012) and 600-1000 ng/ml (11.05%; 95% CI: 2.40-19.71, p = 0.013) showed significant improvement in the total BPRS score. Dosages above 1000 ng/ml showed greater improvement (25.36%; 95% CI: 13.08-37.64, p < 0.001) of the total BPRS score but more severe ADRs than dosages below 1000 ng/ml (OR: 31.72; 95% CI: 1.04-968.81, p = 0.048). CONCLUSION: The AGNP therapeutic reference range (350-600 ng/ml) is useful, and a dose above 1000 ng/ml is potentially more effective but carries the risk of severe ADRs in the central nervous system.

    DOI: 10.1111/acps.13264

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  • Excess All-Cause Mortality During the COVID-19 Outbreak in Japan.

    Takashi Yorifuji, Naomi Matsumoto, Soshi Takao

    Journal of epidemiology   31 ( 1 )   90 - 92   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    DOI: 10.2188/jea.JE20200492

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  • MACC1 expression is an indicator of recurrence in early-stage glottic cancer 国際誌

    Takuma Makino, Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Soshi Takao, Hidenori Marunaka, Kentaro Miki, Naoki Akisada, Yusuke Akagi, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

    Japanese Journal of Clinical Oncology   50 ( 4 )   392 - 398   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer. Methods Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n = 52) were immunohistochemically analyzed to explore MACC1 expression. The clinical records associated with each case were also examined. Recurrence-free survival (RFS) was estimated using the Kaplan- Meier method, and between-group RFS differences were assessed using the log-rank test. The multivariate analyses were evaluated using the Cox's proportional-hazard model. Results Patients were treated with only radiotherapy (RT) (n = 37, including 18 with T1 disease and 19 with T2 disease), or with chemoradiotherapy (CRT) (n = 15, including 1 with T1 disease and 14 with T2 disease). Eleven patients demonstrated local recurrence and two patients experienced cervical lymph node recurrence. Tumor specimens were MACC1-positive in 9 of the 13 (69.2%) patients with local or neck recurrence, and 7 of the 11 (63.6%) patients with local recurrence. The RFS rate of patients who were treated with only RT was significantly lower than that of patients who were treated with CRT (P = 0.0243). The RFS rate was significantly lower in cases with MACC1 expression than in those without MACC1 expression (P = 0.0003). Multivariate analysis revealed that MACC1 expression was an independent risk factor of local recurrence (P = 0.0016). Conclusion MACC1 is an independent indicator of recurrence related to RFS in early-stage glottic cancer.

    DOI: 10.1093/jjco/hyz206

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  • Switching strategies for antipsychotic monotherapy in schizophrenia: a multi-center cohort study of aripiprazole

    Yoshiaki Obayashi, Satoshi Mitsui, Shinji Sakamoto, Nozomu Minao, Bunta Yoshimura, Toshiki Kono, Yuji Yada, Yuko Okahisa, Soshi Takao, Yoshiki Kishi, Toshihiko Takeda, Manabu Takaki, Norihito Yamada

    PSYCHOPHARMACOLOGY   237 ( 1 )   167 - 175   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Rationale Changing antipsychotics of patients with chronic schizophrenia involves several risks. Switching to aripiprazole is especially difficult. We investigated switching methods and related factors for successful switching patients with chronic schizophrenia to aripiprazole. Objectives This study was a multi-center historical cohort study and approved by the research ethics committee of Okayama University Hospital and Okayama Psychiatric Medical Center. We compared survival proportions of 178 chronic schizophrenia patients who continued aripiprazole monotherapy for 6 months after non-direct switching (add-on switching (n = 45), cross switching (n = 62)) or direct switching (n = 71). We adjusted possible confounders using a Cox proportional hazards model. Results Of patients with chronic schizophrenia, 56.7% (101/178) were switched to aripiprazole monotherapy, and 55.0% (98/178) showed improvement in symptoms as demonstrated by the Clinical Global Impression Severity score. Kaplan-Meier survival curves showed that non-direct switching had a higher survival proportion than direct switching (log-rank test, p = 0.012). Even after adjusting for several variables using a Cox proportional hazards model, add-on switching had a significantly lower hazard at 6 months than direct switching (hazard ratio 0.42, 95% confidence interval 0.21-0.82, P = 0.01). In cases of switching to aripiprazole for psychiatric symptoms, non-direct switching had a lower hazard than direct switching (hazard ratio 0.41, 95% confidence interval 0.21-0.81, P = 0.01) but was not significant for adverse reaction. When aripiprazole was switched from olanzapine, add-on switch showed the lowest hazard ratio for continuation (hazard ratio 0.29, 95% confidence interval 0.07-1.11, P = 0.07). Conclusions Flexibility in strategies when switching to aripiprazole may induce a better outcome for patients with chronic schizophrenia.

    DOI: 10.1007/s00213-019-05352-7

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  • 統合失調症患者におけるアリピプラゾール単剤治療への切替方法についての検討(多施設コホート研究) 国際誌

    大林芳明, 大林芳明, 大林芳明, 大林芳明, 光井聡, 酒本真次, 皆尾望, 吉村文太, 耕野敏樹, 矢田勇慈, 岡久祐子, 高尾総司, 来住由樹, 武田俊彦, 高木学, 山田了士

    日本臨床精神神経薬理学会プログラム・抄録集   237 ( 1 )   167 - 175   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00213-019-05352-7

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  • Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis. 査読 国際誌

    Oka A, Ninomiya T, Fujiwara T, Takao S, Sato Y, Gion Y, Minoura A, Haruna SI, Yoshida N, Sakuma Y, Izuhara K, Ono J, Taniguchi M, Haruna T, Higaki T, Kariya S, Koyama T, Takabayashi T, Imoto Y, Sakashita M, Kidoguchi M, Nishizaki K, Fujieda S, Okano M

    Allergology international : official journal of the Japanese Society of Allergology   69 ( 3 )   417 - 423   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.alit.2019.12.004

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  • Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. 国際誌

    Akiko Sugaya, Kunihiro Fukushima, Soshi Takao, Norio Kasai, Yukihide Maeda, Akie Fujiyoshi, Yuko Kataoka, Shin Kariya, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   126   109619 - 109619   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: Reading and writing skills are important for hearing-impaired children since these skills help them to develop their language skills, but the prevalence of reading/writing difficulties and its effects on language development aspects among them are unclear. In this study, we identified language development features and demographic factors of Japanese hearing-impaired children diagnosed as having reading/writing difficulties. METHODS: We analyzed data from a total of 546 sever-to-profound pre-school and elementary school hearing-impaired children for this study. Children with reading/writing difficulties (Group A) were defined as children obtaining low scores (-1.5 SD compared to others in the same grade) in the Screening Test of Reading and Writing for Japanese Primary School Children (STRAW), and we compared other language development features (communication ability, vocabulary, syntax and academic achievement) and demographic factors to those of hearing-impaired children with normal reading and writing skills (Group B). We assessed language development domains as outcomes using the Assessment of Language Development for Japanese Children (ALADJIN) package, and analyzed the results stratified by age groups (5-6, 7-8, 9-10, and 11-12 years) using multiple regression analyses. RESULTS: The prevalence of reading/writing difficulties was 20.1% among the participants. Almost all point estimates in each language development domain showed better odds ratios (OR) except Criterion Referenced Test -II (CRT-II) mathematics in 11- to 12-year-olds in fully-adjusted models. Among 9- to 10-year-olds, the ORs (95% confidence interval) for fair academic achievement measured by CRT-II were 2.60 (1.09-6.20) for Japanese and 3.02 (1.29-7.11) for mathematics in Group B, even after adjusting for possible confounding factors. CONCLUSIONS: Reading and writing are important for language development of hearing-impaired children, especially for academic achievement during the middle phase of elementary school. Screening for reading/writing difficulties is important for appropriate intervention and to prevent language and academic delays among hearing-impaired children.

    DOI: 10.1016/j.ijporl.2019.109619

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  • 初期診断が気分障害であった患者における抗NMDA受容体抗体保有率の検討 査読 国際誌

    河合弘樹, 高木学, 酒本真次, 柴田敬, 土田彩加, 吉村文太, 矢田勇慈, 矢田勇慈, 松本菜見子, 佐藤恒太, 阿部康二, 岡久祐子, 来住由樹, 高尾総司, 筒井幸, 神林崇, 神林崇, 田中恵子, 山田了士

    日本臨床精神神経薬理学会プログラム・抄録集   29 ( 9 )   1041 - 1050   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.euroneuro.2019.07.137

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  • Relationship between workplace social capital and suicidal ideation in the past year among employees in Japan: a cross-sectional study. 国際誌

    Daisuke Hori, Soshi Takao, Ichiro Kawachi, Yuh Ohtaki, Christina-Sylvia Andrea, Tsukasa Takahashi, Nagisa Shiraki, Tomohiko Ikeda, Yu Ikeda, Shotaro Doki, Yuichi Oi, Shinichiro Sasahara, Ichiyo Matsuzaki

    BMC public health   19 ( 1 )   919 - 919   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: A growing body of evidence has demonstrated the associations between social capital and health. In residential or geographical areas, social capital has attracted attention for its protective effects against suicide. However, to this date, the relationship between social capital and suicidal ideation is not fully elaborated in the occupational setting. Therefore, the aim of the present study was to examine the association between workplace social capital and suicidal ideation in the past year among employees in Japan. METHODS: A cross-sectional, web-based survey was conducted in February/March 2017 via an anonymous self-administered questionnaire distributed to workers in Tsukuba Science City, Japan. Binomial logistic regressions were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for suicidal ideation in the past year, controlling for age group, marital status, educational attainment, and annual household income. The results were shown stratified by sex and occupation. RESULTS: In total, 7255 of 19,481 workers responded, out of which we could analyze 6325 responses (4030 men, 2295 women). The prevalence of suicidal ideation in the past year was 5.9% for men and 7.8% for women. Low workplace social capital was statistically significantly associated with suicidal ideation both for men (OR = 2.57, 95% CI = 1.72-3.83) and for women (OR = 1.75, 95% CI = 1.15-2.66), compared with high workplace social capital after controlling for socioeconomic factors. CONCLUSION: Higher workplace social capital was associated with a reduced risk of suicidal ideation in the past year. Promoting workplace social capital could contribute to preventing suicide among employees in Japan.

    DOI: 10.1186/s12889-019-7244-9

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  • Reciprocity of social support is associated with psychological distress and suicidal ideation in older Japanese people: A population-based study. 国際誌

    Yuki Mizuno, Hiroyuki Hikichi, Masayuki Noguchi, Ichiro Kawachi, Soshi Takao

    Social science & medicine (1982)   230   131 - 137   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.socscimed.2019.04.010

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  • Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis. 査読 国際誌

    Koyama T, Kariya S, Sato Y, Gion Y, Higaki T, Haruna T, Fujiwara T, Minoura A, Takao S, Orita Y, Kanai K, Taniguchi M, Nishizaki K, Okano M

    Allergology international : official journal of the Japanese Society of Allergology   68 ( 2 )   216 - 224   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.alit.2018.09.002

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  • Risk factors of thrombosis in a single method of microsurgical head and neck reconstruction: A multi-institutional study of 773 reconstructions with a free jejunal graft after total pharyngolaryngoesophagectomy for hypopharyngeal cancer 査読

    Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   38 ( 11 )   1688 - 1694   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Background. The risk factors for thrombus formation in anastomotic vessels in free-flap head and neck reconstruction have been previously reported. However, the evidence is inconsistent.
    Methods. In total, 773 patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled at 12 institutions in Japan from 1995 to 2006. Both the resection area and the applied reconstruction method were constrained to overcome the limitations of previous studies. After the exclusion of recurrent cases, odds ratios (ORs) and 95% confidence intervals (CIs) for thrombosis were calculated in a multivariate logistic regression analysis.
    Results. Postoperative anastomotic thrombosis developed in 23 patients (3.0%). In the multivariate analysis, the OR for thrombosis per 100-mL increase in blood loss was 1.24 (95% CI = 1.02-1.51), even after controlling for other risk factors.
    Conclusion. Our results show that the blood loss volume is an independent risk factor for thrombosis in free tissue grafts. (C) 2016 Wiley Periodicals, Inc.

    DOI: 10.1002/hed.24504

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  • Home visits by commissioned welfare volunteers and psychological distress: a population-based study of 11,312 community-dwelling older people in Japan 査読

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Soshi Takao

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   30 ( 12 )   1156 - 1163   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    ObjectiveNovel countermeasures to increase healthcare expenditures should be explored in rapidly aging societies, including Japan. Social support is a resource for the older people that effectively reduces psychological distress, with or without specialized health service provision. This cross-sectional study was conducted to determine whether home visits by commissioned welfare volunteers (organizations of community residents assigned by national or local governments) are associated with a lower risk of psychological distress among the older people.
    MethodsQuestionnaires were sent in August 2010 to all residents aged 65years in three municipalities (n=21,232) in Okayama Prefecture in Japan; 13,929 were returned (response rate=65.6%). The final sample size for the analysis was 11,312 participants. Home visits, psychological distress (Kessler Psychological Distress Scale: K6&gt;5), and severe psychological distress (K6&gt;13) were measured by the questionnaire. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for psychological distress, adjusting for age, gender, education, marital status, and qualification for long-term care insurance.
    ResultsThe prevalence was 41.4% for psychological distress and 6.5% for severe psychological distress among all participants. Home visits were significantly associated with a lower risk of psychological distress after adjusting for the covariates (OR: 0.71, 95% CI: 0.65-0.77). These associations were comparable for men and women. The association was clearer for severe psychological distress (OR: 0.51, 95% CI: 0.43-0.61).
    ConclusionsHome visits by commissioned welfare volunteers are significantly associated with a lower risk of psychological distress among older people. Copyright (c) 2015 John Wiley & Sons, Ltd.

    DOI: 10.1002/gps.4268

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  • Community-level social capital and psychological distress among the elderly in Japan: a population-based study 査読

    Kobayashi T, Suzuki E, Noguchi M, Kawachi I, Takao S

    PLoS ONE   10 ( 11 )   e0142629   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • How long should we continue S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck?

    Misato Hirai, Yorihisa Orita, Soshi Takao, Tomoyasu Tachibana, Hidenori Marunaka, Seiichiro Makihara, Kentaro Miki, Yasuyuki Noyama, Sayaka Fuji, Akiko Torigoe, Yasuharu Sato, Kazunori Nishizaki

    ACTA OTO-LARYNGOLOGICA   135 ( 10 )   1079 - 1085   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Conclusion: It appears that patients with SCCHN should be recommended to take S-1 for more than 1 year and, if possible, more than 2 years, as adjuvant chemotherapy for SCCHN. Objectives: There is no established consensus on the duration of administration of S-1 as adjuvant chemotherapy for squamous cell carcinoma of the head and neck (SCCHN). Since it might be difficult to undergo prospective randomized study to identify the optimal duration of the administration period of S-1 without a standard, the authors have undergone a retrospective clinical study to decide the tentative standard of therapeutic duration of S-1 as adjuvant chemotherapy for SCCHN. Methods: The clinical records of 89 patients with SCCHN who underwent adjuvant chemotherapy with S-1 were investigated. Results: The median duration of S-1 administration as adjuvant chemotherapy for SCCHN was 7 months (range = 0.1-58 months). Disease-free survivals (DFSs) were generally longer when S-1 administration periods were longer. After adjusting for prognostic factors, S-1 administration periods of 24 months or longer showed significantly lower hazard ratios (HRs) than 0-12 months.

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  • Novel and simple prognostic index for nasal natural killer/T- cell lymphoma

    Hiroyuki Hanakawa, Yorihisa Orita, Yasuharu Sato, Soshi Takao, Hidenori Marunaka, Tokiwa Morishita, Yasuhiko Yamashita, Yasutaka Hori, Shuhei Domae, Ikuo Inokuchi, Seiko Akagi, Eisei Kondo, Noriko Iwaki, Kana Motomiya, Hirokazu Okumura, Tadashi Yoshino, Kazunori Nishizaki

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   36 ( 4 )   551 - 556   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    BackgroundFew studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma.
    MethodsThis was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals.
    ResultsHigh serum levels of C-reactive protein (1.0 mg/dL), lactate dehydrogenase (350 IU/L), and soluble interleukin-2 receptor (sIL-2R; 600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2.
    ConclusionOur NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma. (c) 2013 Wiley Periodicals, Inc. Head Neck36: 551-556, 2014

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  • Social support and suicidal ideation in Japan: are home visits by commissioned welfare volunteers associated with a lower risk of suicidal ideation among elderly people in the community?

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Yoko Kishimoto, Soshi Takao

    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY   49 ( 4 )   619 - 627   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER HEIDELBERG  

    Aims Social support has consistently been reported to be effective in reducing suicidal ideation. This cross-sectional study was performed to determine whether home visits by commissioned welfare volunteers (i.e., organizations of community residents appointed by national or prefectural governments) are associated with a lower risk of suicidal ideation among the elderly.
    Methods In August 2010, questionnaires were sent to all residents aged &gt;= 65 years in three municipalities (n = 21,232) in Okayama prefecture, Japan, and 13,929 returned the questionnaire (response rate: 65.6 %). We finally analyzed 11,218 subjects. Both home visits by commissioned welfare volunteers and suicidal ideation within the last 30 days were assessed in the questionnaire. Odds ratios (ORs) and 95 % confidence intervals (CIs) for suicidal ideation were calculated adjusting for age, sex, educational attainment, and marital status. We then additionally adjusted for instrumental and emotional support, separately.
    Results The prevalence of suicidal ideation was 10.0 % and higher in women than in men (11.4 % vs. 8.0 %). Home visits were significantly associated with a lower risk of suicidal ideation after adjusting for instrumental and emotional support, respectively (OR: 0.60, 95 % CI: 0.53-0.69; OR: 0.67, 95 % CI: 0.59-0.78). In sex-stratified analysis, the association was clearer for women than for men: the corresponding ORs among women were 0.55 (95 % CI: 0.46-0.65) and 0.61 (95 % CI: 0.52-0.73), whereas they were 0.71 (95 % CI: 0.56-0.90) and 0.78 (95 % CI: 0.61-0.99) among men.
    Conclusion Our findings suggest that home visits by commissioned welfare volunteers are significantly associated with lower suicidal ideation among the elderly, particularly in women.

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  • The Bright Side and Dark Side of Workplace Social Capital: Opposing Effects of Gender on Overweight among Japanese Employees

    Tomoko Kobayashi, Etsuji Suzuki, Tuula Oksanen, Ichiro Kawachi, Soshi Takao

    PLOS ONE   9 ( 1 )   e88084   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: A growing number of studies have sought to examine the health associations of workplace social capital; however, evidence of associations with overweight is sparse. We examined the association between individual perceptions of workplace social capital and overweight among Japanese male and female employees.
    Methodology/Principal Findings: We conducted a cross-sectional survey among full-time employees at a company in Osaka prefecture in February 2012. We used an 8-item measure to assess overall and sub-dimensions of workplace social capital, divided into tertiles. Of 1050 employees, 849 responded, and 750 (624 men and 126 women) could be linked to annual health check-up data in the analysis. Binomial logistic regression models were used to calculate odds ratios and 95% confidence intervals for overweight (body mass index: &gt;= 25 kg/m(2), calculated from measured weight and height) separately for men and women. The prevalence of overweight was 24.5% among men and 14.3% among women. Among men, low levels of bonding and linking social capital in the workplace were associated with a nearly 2-fold risk of overweight compared to high corresponding dimensions of social capital when adjusted for age, sleep hours, physiological distress, and lifestyle. In contrast, among women we found lower overall and linking social capital to be associated with lower odds for overweight even after covariate adjustment. Subsequently, we used multinomial logistic regression analyses to assess the relationships between a 1 standard deviation (SD) decrease in mean social capital and odds of underweight/overweight relative to normal weight. Among men, a 1-SD decrease in overall, bonding, and linking social capital was significantly associated with higher odds of overweight, but not with underweight. Among women, no significant associations were found for either overweight or underweight.
    Conclusions/Significance: We found opposite gender relationships between perceived low linking workplace social capital and overweight among Japanese employees.

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  • Group involvement and self-rated health among the Japanese elderly: an examination of bonding and bridging social capital

    Yoko Kishimoto, Etsuji Suzuki, Toshihide Iwase, Hiroyuki Doi, Soshi Takao

    BMC PUBLIC HEALTH   13   1189   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: To date, only a small amount of research on bonding/bridging social capital has separately examined their effects on health though they have been thought to have differential effects on health outcomes. By using a large population-based sample of elderly Japanese people, we sought to investigate the association between bonding and bridging social capital and self-rated health for men and women separately.
    Methods: In August 2010, questionnaires were sent to all residents aged &gt;= 65 years in three municipalities in Okayama prefecture (n = 21232), and 13929 questionnaires were returned (response rate: 65.6%). Social capital was measured from survey responses to questions on participation in six different types of groups: a) the elderly club or sports/hobby/culture circle; b) alumni association; c) political campaign club; d) citizen's group or environmental preservation activity; e) community association; and f) religious organization. Participant perception of group homogeneity (gender, age, and previous occupation) was used to divide social capital into bonding or bridging. Odds ratios (ORs) and 95% confidence intervals (CIs) for poor self-rated health were calculated.
    Results: A total of 11146 subjects (4441 men and 6705 women) were available for the analysis. Among men, bonding and bridging social capital were inversely associated with poor self-rated health (high bonding social capital; OR: 0.55, 95% CI: 0.31-0.99; high bridging social capital; OR: 0.62, 95% CI: 0.48-0.81) after adjusting for age, educational attainment, smoking status, frequency of alcohol consumption, overweight, living arrangements, and type-D personality. The beneficial effect among women was more likely limited to bonding social capital (high bonding social capital; OR: 0.34, 95% CI: 0.12-1.00), and the association between bridging social capital and self-rated health was less clear (high bridging social capital; OR: 0.69, 95% CI: 0.44-1.07).
    Conclusions: Bonding/bridging social capital could have differential associations with self-rated health among the Japanese elderly depending on the individual's sex. Considering the lack of consensus on how to measure bonding and bridging social capital, however, we need to carefully assess the generalizability of our findings. Further research is warranted to identify health-relevant dimensions of social capital in different cultural or economic settings.

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  • Workplace Determinants of Social Capital: Cross-Sectional and Longitudinal Evidence from a Finnish Cohort Study

    Tuula Oksanen, Ichiro Kawachi, Anne Kouvonen, Soshi Takao, Etsuji Suzuki, Marianna Virtanen, Jaana Pentti, Mika Kivimaki, Jussi Vahtera

    PLOS ONE   8 ( 6 )   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Objective: To examine which contextual features of the workplace are associated with social capital.Methods: This is a cohort study of 43,167 employees in 3090 Finnish public sector workplaces who responded to a survey of individual workplace social capital in 2000-02 (response rate 68%). We used ecometrics approach to estimate social capital of work units. Features of the workplace were work unit's demographic and employment patterns and size, obtained from employers' administrative records. We used multilevel-multinomial logistic regression models to examine cross-sectionally whether these features were associated with social capital between individuals and work units. Fixed effects models were used for longitudinal analyses in a subsample of 12,108 individuals to examine the effects of changes in workplace characteristics on changes in social capital between 2000 and 2004.Results: After adjustment for individual characteristics, an increase in work unit size reduced the odds of high levels of individual workplace social capital (odds ratio 0.94, 95% confidence interval 0.91-0.98 per 30-person-year increase). A 20% increase in the proportion of manual and male employees reduced the odds of high levels of social capital by 8% and 23%, respectively. A 30% increase in temporary employees and a 20% increase in employee turnover were associated with 11% (95% confidence interval 1.04-1.17) and 24% (95% confidence interval 1.18-1.30) higher odds of having high levels of social capital respectively). Results from fixed effects models within individuals, adjusted for time-varying covariates, and from social capital of the work units yielded consistent results.Conclusions: These findings suggest that workplace social capital is contextually patterned. Workplace demographic and employment patterns as well as the size of the work unit are important in understanding variations in workplace social capital between individuals and workplaces.

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  • Individual-level social capital and self-rated health in Japan: An application of the Resource Generator

    Tomoko Kobayashi, Ichiro Kawachi, Toshihide Iwase, Etsuji Suzuki, Soshi Takao

    SOCIAL SCIENCE & MEDICINE   85   32 - 37   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Despite accumulating evidence of associations between social capital and health in public health research, a criticism of the field has been that researchers have exclusively focused on concepts of social cohesion to the exclusion of individual-level approaches. In the present study, we evaluated the association between social capital measured by the Resource Generator (an individual-level assessment of access to social capital) and self-rated health among Japanese population in a cross-sectional study. A postal survey of 4000 randomly selected residents in Okayama City (western Japan) was conducted in February 2009. We divided the overall scores from the Resource Generator Japan scale into quartiles. Odds ratios (ORs) and 95% confidence intervals (CIs) for self-rated health were calculated separately by sex. Individuals with the highest quartile of scores had significantly lower odds of poor health compared to the lowest group after covariate adjustment among both men and women (men; OR: 0.45, 95% CI: 0.24-0.86, women; OR: 0.44, 95% CI: 0.25-0.79, respectively) and there were also significant dose-response relationships. In the sub-domains of Resource Generator Japan scale, a differential pattern was observed by sex. Women showed a clear dose response relationship with health across all four sub-scales (domestic resources, expert advice, personal skills, and problem solving resources). In contrast, only the domain of expert advice exhibited a strong association with men's health. Among both men and women individual-level social capital measured by the Resource Generator was related to reduced odds of poor health even after taking into account individual confounders. Although we cannot exclude reverse causation due to the cross-sectional design, our study adds to the accumulating evidence of the potential utility of the Resource Generator for evaluating the relationship between individual-level access to social capital and health. (C) 2013 Elsevier Ltd. All rights reserved.

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  • Residential proximity to major roads and adverse birth outcomes: a hospital-based study 査読

    Yorifuji, Takashi, Naruse, Hiroo, Kashima, Saori, Takao, Soshi, Murakoshi, Takeshi, Doi, Hiroyuki, Kawachi, Ichiro

    ENVIRONMENTAL HEALTH   12 ( 34 )   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: Exposure to air pollution has been demonstrated to increase the risk of preterm birth and low birth weight (LBW). Although evidence has accumulated on characteristics associated with increased risk of air pollution-related health effects, most studies have been conducted in the adult population and evidence on reproductive outcomes is limited. We examined whether socio-economic position (SEP) and parental characteristics (parental behavior and co-morbidity) modified the relationship between air pollution and adverse birth outcomes. Methods: Data were extracted from a perinatal hospital database based in Shizuoka, Japan. We restricted the analysis to mothers who delivered live-born single births from January 1997 to December 2010 (n = 16,615). Each birth was assigned proximity to major roads. Multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated for the outcomes of preterm birth and term LBW. We stratified subjects by individual/area-level SEP and parental characteristics. We then measured interactions on the additive scale between the respective factors and exposure. Results: Lower SEP at both individual and area levels was asso

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  • Shift Work and Diabetes Mellitus among Male Workers in Japan: Does the Intensity of Shift Work Matter? 査読

    Katsuhiko Ika, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Hiroyuki Doi

    ACTA MEDICA OKAYAMA   67 ( 1 )   25 - 33   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The purpose of this study was to examine the association between shift work and diabetes mellitus by separating shift workers according to the intensity of their shift work (seasonal shift work and continuous shift work). Between May and October 2009, we collected data from annual health checkups and questionnaires at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate: 96.2%, men/women = 1,314/287). Diabetes mellitus was defined as hemoglobin Alc &gt;= 6.5% and fasting blood sugar &gt;= 126 mg/dl. After exclusions, which included all the women and clerical workers because they did not work in shifts, we analyzed 475 skilled male workers. After adjusting for age, smoking status, frequency of alcohol consumption, and cohabitation status, odds ratios for diabetes mellitus were 0.98 (95% confidence interval [CI]: 0.28-4.81) and 2.10 (95% CI: 0.77-5.71) among seasonal shift workers and continuous shift workers, respectively, compared with non-shift workers. In an age-stratified analysis (&lt; 45 years vs. &gt;= 45 years), the association between continuous shift work and diabetes mellitus was more pronounced among older participants. Compared with non-shift workers, the risk of diabetes mellitus was increased among continuous shift workers, whereas its effect is limited among seasonal shift workers.

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  • Critical Appraisal of the 1977 Diagnostic Criteria for Minamata Disease

    Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada, Ichiro Kawachi

    ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH   68 ( 1 )   22 - 29   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD  

    Large-scale food poisoning caused by methylmercury was identified in Minamata, Japan, in the 1950s (Minamata disease). Although the diagnostic criteria for the disease remain current, few studies have been carried out to assess the diagnostic accuracy of the criteria. From a 1971 population-based investigation, data from 2 villages were selected: Minamata (high-exposure area; n = 779) and Ariake (low-exposure area; n = 755). The authors examined the prevalence of neurologic signs characteristic of methylmercury poisoning and the validity of the criteria. A substantial number of residents in the exposed area exhibited neurologic signs even after excluding officially certified patients. Using paresthesia of the extremities as the gold standard of diagnosis, the criteria had a sensitivity of 66%. The current diagnostic criteria as well as the official certification system substantially underestimate the incidence of Minamata disease.

    DOI: 10.1080/19338244.2011.627894

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  • Contribution of smoking to the gender gap in life expectancy in Japan 査読

    Yorifuji, T, Takao, S, Inoue, S, Tanihara, S, Kawachi, I

    Public Health   127 ( 5 )   482 - 484   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Clarifying the Use of Aggregated Exposures in Multilevel Models: Self-Included vs. Self-Excluded Measures

    Etsuji Suzuki, Eiji Yamamoto, Soshi Takao, Ichiro Kawachi, S. V. Subramanian

    PLOS ONE   7 ( 12 )   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: Multilevel analyses are ideally suited to assess the effects of ecological (higher level) and individual (lower level) exposure variables simultaneously. In applying such analyses to measures of ecologies in epidemiological studies, individual variables are usually aggregated into the higher level unit. Typically, the aggregated measure includes responses of every individual belonging to that group (i.e. it constitutes a self-included measure). More recently, researchers have developed an aggregate measure which excludes the response of the individual to whom the aggregate measure is linked (i.e. a self-excluded measure). In this study, we clarify the substantive and technical properties of these two measures when they are used as exposures in multilevel models.Methods: Although the differences between the two aggregated measures are mathematically subtle, distinguishing between them is important in terms of the specific scientific questions to be addressed. We then show how these measures can be used in two distinct types of multilevel models-self-included model and self-excluded model-and interpret the parameters in each model by imposing hypothetical interventions. The concept is tested on empirical data of workplace social capital and employees' systolic blood pressure.Results: Researchers assume group-level interventions when using a self-included model, and individual-level interventions when using a self-excluded model. Analytical re-parameterizations of these two models highlight their differences in parameter interpretation. Cluster-mean centered self-included models enable researchers to decompose the collective effect into its within-and between-group components. The benefit of cluster-mean centering procedure is further discussed in terms of hypothetical interventions.Conclusions: When investigating the potential roles of aggregated variables, researchers should carefully explore which type of model-self-included or self-excluded-is suitable for a given situation, particularly when group sizes are relatively small.

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  • Workplace social capital and risk of chronic and severe hypertension: a cohort study

    Tuula Oksanen, Ichiro Kawachi, Markus Jokela, Anne Kouvonen, Etsuji Suzuki, Soshi Takao, Marianna Virtanen, Jaana Pentti, Jussi Vahtera, Mika Kivimaki

    JOURNAL OF HYPERTENSION   30 ( 6 )   1129 - 1136   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: The association between workplace factors and the development of hypertension remains uncertain. We examined the risk of hypertension as a function of workplace social capital, that is, social cohesion, trust and reciprocity in the workplace.
    Methods: A total of 11 777 male and 49 145 female employees free of chronic hypertension at baseline in 2000-2004 were followed up for incident hypertension until the end of 2005 (the Finnish Public Sector Study). We used survey responses from the participants and their coworkers in the same work unit to assess workplace social capital at baseline. Follow-up for incident hypertension was based on record linkage to national health registers (mean follow-up 3.5 years, 1424 incident hypertension cases).
    Results: Male employees in work units characterized by low workplace social capital were 40-60% more likely to develop chronic hypertension compared to men in work units with high social capital [age-adjusted hazard ratio 1.57, 95% confidence interval (CI) 1.15-2.14 for self-assessed social capital and 1.41, 95% CI 1.01-1.97 for coworkers' assessment]. According to path analysis adjusted for covariates, the association between low self-reported social capital and hypertension was partially mediated by obesity (P for pathway = 0.02) and alcohol consumption (P = 0.03). For coworker-assessed social capital, the corresponding mediation pathways did not reach statistical significance (P = 0.055 and 0.22, respectively). No association between workplace social capital and hypertension was found for women.
    Conclusion: These data suggest that low self-reported workplace social capital is associated with increased near-term risk of hypertension in men in part due to unhealthy lifestyle.

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  • Long working hours and metabolic syndrome among Japanese men: a cross-sectional study

    Tomoko Kobayashi, Etsuji Suzuki, Soshi Takao, Hiroyuki Doi

    BMC PUBLIC HEALTH   12   395   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: The link between long working hours and health has been extensively studied for decades. Despite global concern regarding metabolic syndrome, however, no studies to date have solely evaluated the relationship between long working hours and that syndrome. We therefore examined the association between long working hours and metabolic syndrome in a cross-sectional study.
    Methods: Between May and October 2009, we collected data from annual health checkups and questionnaires from employees at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate: 96.2%; 1,314 men, 287 women). After exclusions, including women because of a lack of overtime work, the analysis was performed for 933 men. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for metabolic syndrome. Further, we conducted a stratified analysis by age-group (&lt;40 years vs. &gt;= 40 years).
    Results: Metabolic syndrome was identified in 110 workers (11.8%). We observed a positive association between working hours and metabolic syndrome after adjusting for age, occupation, shift work, smoking status, frequency of alcohol consumption, and cohabiting status. Compared with subjects who worked 7-8 h/day, multivariate ORs for metabolic syndrome were 1.66 (95% CI, 0.91-3.01), 1.48 (95% CI, 0.75-2.90), and 2.32 (95% CI, 1.04-5.16) for those working 8-9 h/day, 9-10 h/day, and &gt;10 h/day, respectively. Similar patterns were obtained when we excluded shift workers from the analysis. In age-stratified analysis, the corresponding ORs among workers aged &gt;= 40 years were 2.02 (95% CI, 1.04-3.90), 1.21 (95% CI, 0.53-2.77), and 3.14 (95% CI, 1.24-7.95). In contrast, no clear association was found among workers aged &lt;40 years.
    Conclusions: The present study suggests that 10 h/day may be a trigger level of working hours for increased risk of metabolic syndrome among Japanese male workers.

    DOI: 10.1186/1471-2458-12-395

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  • Does Open-air Exposure to Volatile Organic Compounds near a Plastic Recycling Factory Cause Health Effects? (vol 54, pg 79, 2012)

    Takashi Yorifuji, Miyuki Noguchi, Toshihide Tsuda, Etsuji Suzuki, Soshi Takao, Saori Kashima, Yukio Yanagisawa

    JOURNAL OF OCCUPATIONAL HEALTH   54 ( 3 )   254 - 254   2012年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

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  • Maternal Working Hours and Early Childhood Overweight in Japan: A Population-based Study 査読

    Toshiharu Mitsuhashi, Etsuji Suzuki, Soshi Takao, Hiroyuki Doi

    JOURNAL OF OCCUPATIONAL HEALTH   54 ( 1 )   25 - 33   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Maternal Working Hours and Early Childhood Overweight in Japan: A Population-based Study: Toshiharu MITSUHASHI, et al. Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Objectives: There has been a growing concern that maternal employment could have adverse or beneficial effects on children's health. Although recent studies demonstrated that maternal employment was associated with a higher risk of childhood overweight, the evidence remains sparse in Asian countries. We sought to examine the relationship between maternal working hours and early childhood overweight in a rural town in Okayama Prefecture. Methods: In February 2008, questionnaires were sent to parents of all preschool children aged &gt;= 3 yr in the town to assess maternal working status (working hours and form of employment), children's body mass index, and potential confounders. Childhood overweight was defined following the age and sex-specific criteria of the International Obesity Task Force. Odds ratios (ORs) and 95% confidence intervals (CIs) for childhood overweight were estimated in a logistic regression. We used generalized estimating equations with an exchangeable correlation matrix, considering the correlation between siblings. Results: We analyzed 364 preschool children. Adjusting for each child's characteristics (age, sex), mother's characteristics (age, obesity, educational attainment, smoking status, and social participation), and family's characteristics (number of siblings), children whose mothers work &lt;8 h/day had a substantially lower risk for being overweight (OR: 0.28, 95% CI: 0.09, 0.93) compared with children of non-working mothers, whereas the relationship was less pronounced among children whose mothers work &gt;= 8 h/day (OR: 0.71, 95% CI: 0.19, 2.68). We observed similar patterns in a stratified analysis by the form of maternal employment. Conclusion: Short maternal working hours are associated with a lower odds of early childhood overweight. (J Occup Health 2012; 54: 25-33)

    DOI: 10.1539/joh.11-0100-OA

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  • Does open-air exposure to volatile organic compounds near a plastic recycling factory cause health effects? 査読

    Yorifuji T, Noguchi M, Tsuda T, Suzuki E, Takao S, Kashima S, Yanagisawa Y

    Journal of occupational health   54 ( 2 )   79 - 87   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1539/joh.11-0202-oa

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  • The role of medicine in the decline of post-War infant mortality in Japan 査読

    Takashi Yorifuji, Shinichi Tanihara, Sachiko Inoue, Soshi Takao, Ichiro Kawachi

    PAEDIATRIC AND PERINATAL EPIDEMIOLOGY   25 ( 6 )   601 - 608   2011年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Yorifuji T, Tanihara S, Inoue S, Takao S, Kawachi I. The role of medicine in the decline of post-War infant mortality in Japan. Paediatric and Perinatal Epidemiology 2011; 25: 601-608.
    The infant mortality rate (IMR) in Japan declined dramatically in the immediate post-War period (1947-60) in Japan. We compared the time trends in Growth Domestic Product (GDP) in Japan against declines in IMR. We then conducted a prefecture-level ecological analysis of the rate of decline in IMR and post-neonatal mortality from 1947 to 1960, focusing on variations in medical resources and public health strategies. IMR in Japan started to decline after World War II, even before the era of rapid economic growth and the introduction of a universal health insurance system in the 1960s. The mortality rates per 1000 infants in 2009 were 2.38 for IMR, 1.17 for neonatal mortality and 1.21 for post-neonatal mortality. The rate of decline in IMR and preventable IMR (PIMR) during the post-War period was strongly correlated with prefectural variations in medical resources (per capita physicians, nurses, and proportion of in-hospital births). The correlation coefficients comparing the number of physicians in 1955 with the declines in IMR and PIMR from 1947 to 1960 were 0.46 [95% confidence interval (CI) 0.19, 0.66] and 0.39 [95% CI 0.11, 0.61], respectively. By contrast, indicators of public health strategies were not associated with IMR decline. The IMR in Japan has been decreasing and seems to be entering a new era characterised by lower neonatal compared with post-neonatal mortality. Furthermore, the post-War history of Japan illustrates that improvement in infant mortality is attributable to the influence of medical care, even in the absence of rapid economic development.

    DOI: 10.1111/j.1365-3016.2011.01216.x

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  • Workplace Social Capital and Adherence to Antihypertensive Medication: A Cohort Study

    Tuula Oksanen, Ichiro Kawachi, Anne Kouvonen, Etsuji Suzuki, Soshi Takao, Noora Sjosten, Marianna Virtanen, Jaana Pentti, Jussi Vahtera, Mika Kivimaki

    PLOS ONE   6 ( 9 )   e24732   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    Background: While hypertension is a common and treatable health problem, adherence to antihypertensive medication remains a challenge. This study examines the hypothesis that workplace social capital may influence adherence to antihypertensive medication among hypertensive employees.
    Methodology/Principal Findings: We linked survey responses to nationwide pharmacy records for a cohort of 3515 hypertensive employees (mean age 53.9 years, 76% women) who required continuous antihypertensive drug therapy (the Finnish Public Sector study). A standard scale was used to measure workplace social capital from co-workers&apos; assessments and self-reports in 2000-2004. Non-adherence to antihypertensive medication was determined based on the number of days-not-treated at the year following the survey using comprehensive prescription records. Negative binomial regression models were conducted adjusting for socio-demographic characteristics, duration of hypertension, behaviour-related risk factors, and co-morbid conditions. The overall rate of days-not-treated was 20.7 per person-year (78% had no days-not-treated). Higher age, obesity, and presence of somatic co-morbidities were all associated with better adherence, but this was not the case for co-worker-assessed or self-reported workplace social capital. The rate of days-not-treated was 19.7 per person-year in the bottom fourth of co-worker-assessed workplace social capital, compared to 20.4 in the top fourth. The corresponding rate ratio from the fully-adjusted model was 0.95 (95% confidence interval (CI) 0.58-1.56). In a subgroup of 907 new users of antihypertensive medication this rate ratio was 0.98 (95% CI 0.42-2.29).
    Conclusions/Significance: We found no consistent evidence to support the hypothesized effect of workplace social capital on adherence to drug therapy among employees with chronic hypertension.

    DOI: 10.1371/journal.pone.0024732

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  • Diesel vehicle emission and death rates in Tokyo, Japan: A natural experiment

    Takashi Yorifuji, Ichiro Kawachi, Mariko Kaneda, Soshi Takao, Saori Kashima, Hiroyuki Doi

    SCIENCE OF THE TOTAL ENVIRONMENT   409 ( 19 )   3620 - 3627   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Evidence linking air pollution with adverse cardiopulmonary outcomes is accumulating. However, few studies have been conducted to evaluate whether vehicle emission control improves public health. We thus evaluated the effect of a diesel emission control law on mortality rates in 23 wards of Tokyo metropolitan area, Japan. We obtained daily counts of mortality and concentrations of nitrogen dioxide (NO2) and particulate matter less than 2.5 mu m in diameter (PM2.5) from April 2003 to December 2008. Time-series and interrupted time-series analysis were employed to analyze the data in two periods: prior to the introduction of tighter restrictions (April 2003 to March 2006) and after the enforcement (April 2006 to December 2008). Concentrations of air pollutants gradually decreased during the study period: from 36.3 ppb (NO2) and 22.8 mu g/m(3) (PM2.5) to 32.1 ppb and 20.3 mu g/m(3), respectively. Air pollutants were positively associated with circulatory and pulmonary disease mortality, especially cerebrovascular disease. Each same-day PM2.5 increase of 10 mu g/m(3) was associated with a 1.3% increase in cerebrovascular mortality rate (95% confidence interval: 0.2-2.4). Rate ratios were attenuated after the enforcement in most of the outcomes, probably due to reduced toxicity of the pollutants. In the crude interrupted time-series analysis, reductions of standardized mortality rates after the enforcement were the greatest in high traffic areas. Even after adjustment of longer-time trend, mortality rate from cerebrovascular disease was reduced by 8.50% (p<.001) with dose-response relationship. However, the declines in other cause-specific mortality became equivocal. This natural experiment in Tokyo suggests that emission controls improved air quality. Although suggestive, further data are needed to conclusively demonstrate an impact on mortality rates. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.scitotenv.2011.06.002

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  • Regional disparities in compliance with tobacco control policy in Japan: an ecological analysis 査読

    Takashi Yorifuji, Shinichi Tanihara, Soshi Takao, Ichiro Kawachi

    TOBACCO CONTROL   20 ( 5 )   374 - 379   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:B M J PUBLISHING GROUP  

    Background The slow progress of tobacco control policy in Japan reflects the tension among the interests of the Finance Ministry (which remains the majority shareholder of Japan Tobacco, Inc), the Health Ministry, tobacco growers and consumers.
    Methods We sought to examine regional disparities in compliance with national tobacco control legislation (the 2003 Health Promotion Law). Specifically, we sought to examine whether prefecture-level compliance with legislation was correlated with decreases in smoking prevalence, and decreases in lung cancer mortality rates. We also examined whether prefectural involvement in growing tobacco was associated with lower compliance with the law.
    Results From 2001 to 2007, higher prefectural compliance with tobacco control laws was associated with decreased prevalence of smoking. Decreased tobacco consumption was in turn associated with declining lung cancer mortality. Prefectures involved in growing tobacco exhibited lower levels of compliance with national tobacco control laws. The same prefectures also exhibited the worst improvement in smoking prevalence.
    Conclusions This study in Japan suggests that tobacco control policies are being unevenly implemented across prefectures, and that measures to counteract the influence of local tobacco culture are required to reduce the disparities in regional tobacco control outcomes in that country.

    DOI: 10.1136/tc.2010.041442

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  • Workplace Social Capital and All-Cause Mortality: A Prospective Cohort Study of 28043 Public-Sector Employees in Finland

    Tuula Oksanen, Ichiro Kawachi, S. V. Subramanian, Mika Kivimaki, Jaana Pentti, Paula Salo, Marianna Virtanen, Jussi Vahtera, Soshi Takao, Etsuji Suzuki, Anne Kouvonen

    AMERICAN JOURNAL OF PUBLIC HEALTH   101 ( 9 )   1742 - 1748   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PUBLIC HEALTH ASSOC INC  

    Objectives. We examined the association between workplace social capital and all-cause mortality in a large occupational cohort from Finland.
    Methods. We linked responses of 28043 participants to surveys in 2000 to 2002 and in 2004 to national mortality registers through 2009. We used repeated measurements of self- and coworker-assessed social capital. We carried out Cox proportional hazard and fixed-effects logistic regressions.
    Results. During the 5-year follow-up, 196 employees died. A 1-unit increase in the mean of repeat measurements of self-assessed workplace social capital (range 1-5) was associated with a 19% decrease in the risk of all-cause mortality (age- and gender-adjusted hazard ratio [HR]=0.81; 95% confidence interval [CI) =0.66, 0.99). The corresponding point estimate for the mean of coworker-assessed social capital was similar, although the association was less precisely estimated (age- and gender-adjusted HR=0.77; 95% CI=0.50, 1.20). In fixed-effects analysis, a 1-unit increase in self-assessed social capital across the 2 time points was associated with a lower mortality risk (odds ratio=0.81; 95% CI=0.55, 1.19).
    Conclusions. Workplace social capital appears to be associated with lowered mortality in the working-aged population. (Am J Public Health. 2011;101: 1742-1748. doi:10.2105/AJPH.2011.300166)

    DOI: 10.2105/AJPH.2011.300166

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  • Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan 査読

    Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada

    ENVIRONMENT INTERNATIONAL   37 ( 5 )   907 - 913   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Introduction: It is well-known that prenatal or postnatal exposure to methylmercury can produce neurological signs in adults and children, exemplified by a case of large-scale poisoning in Minamata, Japan, in the 1950s. However, evidence regarding whether pre- or postnatal exposure to methylmercury causes psychiatric symptoms (e.g., impairment of intelligence and mood and behavioral dysfunction) is still limited-excluding cases of fetal Minamata disease patients.
    Methods: We evaluated the effects of pre- or postnatal exposure to methylmercury on psychiatric symptoms using data derived from a 1971 population-based survey in Minamata and neighboring communities. We adopted residential areas as an exposure indicator and psychiatric symptoms as the outcome. Then, we estimated the adjusted prevalence odds ratio (POR) and confidence interval (Cl) of psychiatric symptoms in relation to residential area.
    Results: There were 904 participants in Minamata (high exposure area), 1700 in Goshonoura (middle exposure area), and 913 in Ariake (low exposure area). Compared to the Ariake area, participants in the Minamata area manifested psychiatric symptoms more frequently: PORs for impairment of intelligence and mood and behavioral dysfunction were 5.2 (95% Cl: 3.7-7.3) and 4.4 (95% Cl: 2.9-6.7), respectively. Furthermore, participants with psychiatric symptoms in the Minamata area more frequently had neurological signs. Peaks in prevalence of psychiatric symptoms occurred around age 20 and in older age adults in the area. These findings did not change when we excluded those who had been officially certified as Minamata disease patients by that time.
    Conclusions: The present study suggests a relationship between pre- or postnatal exposure to methylmercury and psychiatric symptoms among the general population in Minamata even after excluding officially certified patients. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.envint.2011.03.008

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  • Residential Proximity to Major Roads and Preterm Births

    Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    EPIDEMIOLOGY   22 ( 1 )   74 - 80   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: Preterm births cause a large public-health burden, and air pollution is considered to be a potential risk factor. We evaluated the association between proximity to major roads (as an index for air pollution) and preterm births, classified by gestational age and specific clinical manifestations.Methods: Data on parental information and birth outcomes were extracted from the database maintained by the perinatal hospital in Shizuoka, Japan. We restricted the analysis to mothers who delivered liveborn single births from 1997 to 2008 (n = 14,226). Using the geocoded residential information, each birth was classified on its proximity to major roads. We estimated the multivariate-adjusted odds ratios and their 95% confidence intervals (CIs) for the association of proximity to major roads with preterm births, using logistic regression.Results: We found positive associations between proximity to major roads and preterm births at all gestational ages. Living within 200 m increased the risk of births before 37 weeks by 1.5 times (95% CI = 1.2-1.8), birth before 32 weeks by 1.6 times (1.1-2.4), and births before 28 weeks by 1.8 times (1.0-3.2). Proximity specifically increased the risk of preterm births with preterm premature rupture of the membranes and with pregnancy hypertension.Conclusions: This study demonstrates that exposure to traffic-related air pollution increases even the risk of preterm births of less than 30 weeks' gestational age and proposes a possible mechanism.

    DOI: 10.1097/EDE.0b013e3181fe759f

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  • Environmental factors and seasonal influenza onset in Okayama city, Japan: case-crossover study

    Tsuchihashi Y, Yorifuji T, Takao S, Suzuki E, Mori S, Doi H, Tsuda T

    Acta Medica Okayama   65 ( 2 )   97 - 103   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/45268

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  • Long-term exposure to methylmercury and its effects on hypertension in Minamata 査読

    Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M

    Environmental Research   110 ( 1 )   40 - 46   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.envres.2009.10.011

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  • Multi-level, cross-sectional study of workplace social capital and smoking among Japanese employees

    Suzuki E, Fujiwara T, Takao S, Subramanian SV, Yamamoto E, Kawachi I

    BMC Public Health   10   2010年

  • Does low workplace social capital have detrimental effect on workers’ health?

    Suzuki E, Takao S, Subramanian SV, Komatsu H, Doi H, Kawachi I

    Social Science & Medicine   70 ( 9 )   1367 - 1372   2010年

  • Green tea consumption and mortality among Japanese elderly people: the prospective Shizuoka elderly cohort. 査読

    Suzuki E, Yorifuji T, Takao S, Komatsu H, Sugiyama M, Ohta T, Ishikawa-Takata K, Doi H

    Annals of epidemiology   19 ( 10 )   732 - 739   2009年10月

  • Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: a population-based cohort study. 査読

    Suzuki E, Yorifuji T, Ueshima K, Takao S, Sugiyama M, Ohta T, Ishikawa-Takata K, Doi H

    Preventive medicine   49 ( 2-3 )   135 - 141   2009年8月

  • Impact of Breastfeeding on Body Weight of Preschool Children in a Rural Area of Japan: Population-based Cross-sectional Study 査読

    Hirokazu Komatsu, Takashi Yorifuji, Toshibide Iwase, Ayako Sasaki, Soshi Takao, Hiroyuki Doi

    ACTA MEDICA OKAYAMA   63 ( 1 )   49 - 55   2009年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    To investigate the effect of exclusive breastfeeding on the likelihood of Japanese preschool children being overweight, population-based cross-sectional survey data from M town in Japan were used. Using the population registry of this town, all 616 preschool children were identified, and a self-administered questionnaire was sent to their parents. The exposure variable of interest was exclusive breastfeeding from. birth to 6 months, and the outcome variable of interest was the children being overweight at preschool age. Statistical analyses used included logistic regression and sensitivity analyses. In the final analyses, we included 448 preschool children. Although all point estimates indicated a protective effect, logistic regression analyses showed no significant reduction in being overweight due to exclusive breastfeeding in the unadjusted model (odds ratio (OR)= 0.70, 95% confidence intervals: 0.30-1.64), the model adjusted for birth weight (OR = 0.70, 95% CI: 030-1.63), the model adjusted for child lifestyle (OR = 0.71, 95% CI: 0.30-1.67), or the model adjusted for parental factors (OR=0.46, 95% CI: 0.15-1.37). In sensitivity analyses, point estimates were not significant, but a protective effect was observed. In conclusion, our results suggest that breastfeeding might have a protective effect on Japanese preschool children against being overweight, although statistical significance was not observed due to the limitation of the statistical power of the findings.

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  • Total mercury content in hair and neurologic signs: historic data from Minamata

    Yorifuji T, Tsuda T, Takao S, Suzuki E, Harada M

    Epidemiology   20 ( 2 )   188 - 193   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/EDE.0b013e318190e73f

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  • Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Morality in Japan: Shizuoka Study 査読

    Takashi Yorifuji, Saori Kashima, Etsuji Suzuki, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    The journal of obstetrics and gynaecology research   19 ( 6 )   S195   2008年11月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/01.ede.0000340088.39958.8b

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  • [Utilization, needs, and related factors for e-learning and its application to education and training in occupational safety and health among enterprises in Japan]. 査読

    Toshiharu Mitsuhashi, Soshi Takao, Akizumi Tsutsumi, Norito Kawakami

    Sangyo eiseigaku zasshi = Journal of occupational health   48 ( 5 )   183 - 91   2006年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    In order to know utilization, needs, and related factors for e-learning and its application to education and training in occupational safety and health (OSH) among enterprises in Japan, a questionnaire survey was conducted of enterprises randomly selected from those with 1,000 or more employees and those with 999 or less (500 for each). Data from 134 (56 and 78, respectively) enterprises were analyzed (response rate, 13%). Among total enterprises, 19% had introduced and 16% planned to introduce e-learning. However, only 7% of larger enterprises and less than 3% of smaller enterprises used e-learning for education and training in OSH. On the other hand, 80-90% of enterprises responded positively to considering the use of e-learning for education and training on various OSH topics for various users. Highly rated merits of e-learning were "can use whenever", "can use anywhere"; and its highly rated obstacles were "cost", "individual PC not available", "insufficient information on efficacy". However, the merit "can monitor training" was significantly associated with the use/plan of e-learning. "Good contents not available" was more frequent among enterprises which used/planned e-learning. The study indicated a greater need for e-learning based OSH education and training, despite a currently low rate of its use. Improvement of e-learning platforms and contents, reduction of cost, and improvement of e-learning infrastructure at work may be needed to facilitate the use of e-learning in OSH.

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  • 職場における管理監督者メンタルヘルス研修前後の知識・態度・行動の変化 査読

    西内 恭子, 高尾 総司, 峰山 幸子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   323 - 323   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 心理社会的職業性ストレスと仕事のパフォーマンス 自記式質問紙による検討 査読

    堤 明純, 川上 憲人, 高尾 総司, 峰山 幸子, 西内 恭子

    産業衛生学雑誌   46 ( 臨増 )   426 - 426   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 管理監督者の傾聴的態度スキルと一般従業員のメンタルヘルスの関連についての検討 査読

    峰山 幸子, 高尾 総司, 西内 恭子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   323 - 323   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職場における管理監督者向けメンタルヘルス基礎研修のRCTによる効果評価 査読

    津田 佳穂, 高尾 総司, 峰山 幸子, 西内 恭子, 堤 明純, 川上 憲人

    産業衛生学雑誌   46 ( 臨増 )   322 - 322   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 疾病を抱える社員の労務管理アドバイス : メンタルヘルス・がん・糖尿病・脳卒中

    馬場, 三紀子, 大嶽, 達哉, 高尾, 総司

    新日本法規出版  2020年9月  ( ISBN:9784788287778

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    総ページ数:4, 276p   記述言語:日本語

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  • 面接シナリオによるメンタルヘルス対応の実務 : ケーススタディ

    高尾, 総司, 森, 悠太, 前園, 健司

    労働新聞社  2020年9月  ( ISBN:9784897618272

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    総ページ数:177p   記述言語:日本語

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  • 社会疫学

    Berkman, Lisa F., 河内, 一郎, Glymour, M. Maria, 高尾, 総司, 藤原, 武男, 近藤, 尚己

    大修館書店  2017年9月  ( ISBN:9784469268294

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    総ページ数:2冊   記述言語:日本語

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  • 完全攻略!もう悩まないストレスチェック制度

    高尾, 総司

    労働新聞社  2016年2月  ( ISBN:9784897615882

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    総ページ数:108p   記述言語:日本語

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  • 健康管理は社員自身にやらせなさい : 労務管理によるメンタルヘルス対策の極意

    高尾, 総司, 岩瀬, 敏秀, 三橋, 利晴, 井家, 克彦

    保健文化社  2014年5月  ( ISBN:9784938435172

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    総ページ数:239p   記述言語:日本語

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  • ソーシャル・キャピタルと健康政策 : 地域で活用するために

    河内, 一郎, 高尾, 総司, Subramanian, S. V., 近藤, 尚己, 白井, こころ, 近藤, 克則

    日本評論社  2013年8月  ( ISBN:9784535586420

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    総ページ数:viii, 455p   記述言語:日本語

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  • Global perspectives on social capital and health

    河内, 一郎, 高尾, 総司, Subramanian, S. V.

    Springer  2013年  ( ISBN:9781461474630

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    総ページ数:x, 349 p.   記述言語:英語

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  • ケースメソッドによる公衆衛生教育 第4版

    篠原出版,東京  2009年 

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  • 職業性ストレスとがん罹患の関連性およびそのメカニズムに関する疫学的研究

    川上, 憲人, 堤, 明純, 津田, 敏秀, 中田, 光紀, 高尾, 総司, 廣川, 空実, 島津, 明人

    川上憲人  2008年5月 

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    総ページ数:175p  

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  • ソーシャル・キャピタルと健康

    河内, 一郎, Subramanian, S. V., Kim, Daniel H, 藤澤, 由和, 高尾, 総司, 濱野, 強

    日本評論社,東京  2008年  ( ISBN:9784535982932

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    総ページ数:217p   記述言語:日本語

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  • 岡山県メタボリックシンドローム改善支援マニュアル I.市町村アプローチ計画策定マニュアル

    岡山県保健福祉部健康対策課,岡山  2007年 

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  • 岡山県メタボリックシンドローム改善支援マニュアル II.市町村向け指導マニュアル

    岡山県保健福祉部健康対策課,岡山  2007年 

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  • ケースメソッドによる公衆衛生教育 第3版

    篠原出版,東京  2006年 

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  • 健康教育・健康管理のレシピ

    南山堂,東京  2005年 

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  • 不平等が健康を損なう

    河内, 一郎, Kennedy, Bruce P., 社会疫学研究会, 西, 信雄, 高尾, 総司, 中山, 健夫

    日本評論社,東京  2004年  ( ISBN:9784535982376

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    総ページ数:ix, 195p   記述言語:日本語

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  • 厚生労働科学研究費補助金健康科学総合研究事業 「行動科学に基づく簡便な生活習慣改善プログラムの開発と効果の検討」 平成15年度研究報告書 主任研究者 足達淑子

    2004年 

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  • 平成14年度中央労働災害防止協会委託 労働安全衛生に関する調査研究報告書

    2003年 

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  • 厚生労働科学研究費補助金健康科学総合研究事業 「行動科学に基づく簡便な生活習慣改善プログラムの開発と効果の検討」 平成14年度研究報告書 主任研究者 足達淑子

    2003年 

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  • 厚生労働省 職場におけるメンタルヘルス対策の事業者等支援事業調査研究報告書 「事業場における精神科医の産業医としての活用に関する調査研究報告書」 平成13年度 中央労働災害防止協会

    2002年 

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▼全件表示

MISC

  • 考察「しごとと健康」【再考】パワハラグレー対応

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 808 )   39 - 40   2021年10月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 考察「しごとと健康」【再考】療養の段階

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 807 )   38 - 39   2021年9月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】復帰基準の考え方

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 806 )   36 - 37   2021年8月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】家族の関与の重要性

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 805 )   31 - 32   2021年7月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】メンタル対応の大原則・三原則

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 804 )   35 - 36   2021年6月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】メンタル対応はなぜ難しいと言われるのか

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 803 )   36 - 37   2021年5月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」【再考】二つの健康管理

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 802 )   41 - 42   2021年4月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 考察「しごとと健康」 ブルーカラーのホワイトカラー化

    森 悠太, 前園 健司, 高尾 総司

    健康管理   68 ( 800 )   34 - 35   2021年2月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 従業員との適切な距離感とは

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 799 )   35 - 36   2021年1月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 片山組事件とメソッド

    森 悠太, 前園 健司, 高尾 総司

    健康管理   67 ( 798 )   36 - 37   2020年12月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

    J-GLOBAL

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  • 考察「しごとと健康」 「モジュラー型」メソッド

    森 悠太, 前園 健司, 高尾 総司

    健康管理   67 ( 797 )   37 - 38   2020年11月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 考察「しごとと健康」 治療上出社と判定出社

    森 悠太, 前園 健司, 高尾 総司

    健康管理   ( 796 )   37 - 38   2020年10月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 慢性統合失調症患者におけるアリピプラゾール単剤治療への切替方法についての検討(多施設コホート研究)

    大林 芳明, 光井 聡, 酒本 真次, 皆尾 望, 吉村 文太, 耕野 敏樹, 矢田 勇慈, 岡久 祐子, 高尾 総司, 来住 由樹, 武田 俊彦, 高木 学, 山田 了士

    精神神経学雑誌   116th ( 2020特別号 )   S426 - S426   2020年9月

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    記述言語:日本語   出版者・発行元:(公社)日本精神神経学会  

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  • AI、データサイエンス、因果推論 産業保健への展望

    鈴木 越治, 三橋 利晴, 山本 倫生, 高尾 総司, 頼藤 貴志, 山本 英二

    産業衛生学雑誌   62 ( 臨増 )   407 - 407   2020年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 健康生成・ストレス対処力SOCと職場のソーシャルキャピタル

    大井 雄一, 堀 大介, 高尾 総司, 室井 慧, 新井 陽, 池田 朝彦, 池田 有, 白木 渚, 高橋 司, 道喜 将太郎, 笹原 信一朗, 松崎 一葉

    産業衛生学雑誌   62 ( 臨増 )   400 - 400   2020年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 人事の主体的関与を引き出すメンタルヘルス対応方法の開発と試行

    森 悠太, 高尾 総司

    産業衛生学雑誌   62 ( 臨増 )   526 - 526   2020年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    J-GLOBAL

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  • 考察「しごとと健康」119 自治体事例の類型

    高尾総司, 森悠太

    健康管理   67 ( 2 )   2020年

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  • 考察「しごとと健康」126 ハイブリッド対応の問題点

    森悠太, 高尾総司, 前園健司

    健康管理   67 ( 9 )   2020年

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  • 考察「しごとと健康」122 産業医役割の原点回帰-面接シナリオによる実現-

    高尾総司, 森悠太

    健康管理   67 ( 5 )   2020年

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  • メンタルヘルス対応困難事例(新型うつを含む)を考える 病名に依存しないメンタルヘルス対応

    高尾 総司

    産業衛生学雑誌   61 ( 臨増 )   204 - 204   2019年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    J-GLOBAL

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  • 復職時の産業医意見と人事意見の関係 産業保健活動に関するニーズ調査から

    高尾 総司, 岸本 卓巳, 勝田 吉彰

    産業衛生学雑誌   60 ( 臨増 )   414 - 414   2018年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Relationship between pure-tone audiogram findings and speech perception among older Japanese persons

    Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

    Acta Oto-Laryngologica   138 ( 2 )   140 - 144   2018年2月

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    記述言語:英語   出版者・発行元:Taylor and Francis Ltd  

    Objective: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. Methods: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson’s correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. Results: SP correlated well (r = −0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = −0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). Conclusion: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

    DOI: 10.1080/00016489.2017.1378435

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  • 地域高齢者におけるソーシャル・キャピタルと希死念慮との関連

    野口正行, 小林朋子, 岩瀬敏秀, 鈴木越治, カワチ イチロー, 高尾総司

    日本社会精神医学会プログラム・抄録集   37th   2018年

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  • 高負荷社員のための「公平な」ストレスチェック制度の運用方法の開発と試行

    高尾総司, 岸本卓巳, 野口正行, 勝田吉彰, 梅木佳則, 小島健一, 村本浩, 山本正晴, 川瀬洋平, 西浦千尋

    総合健康推進財団研究報告書   2016   2018年

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  • 健康の社会的決定要因と総合診療 健康の社会的決定要因(ストレス,労働,失業)

    高尾総司

    ジェネラリスト教育コンソーシアム   10   2018年

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  • Risk factors for wound complications in head and neck reconstruction: 773 free jejunal reconstruction procedures after total pharyngolaryngoesophagectomy

    Narushi Sugiyama, Soshi Takao, Etsuji Suzuki, Yoshihiro Kimata

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   39 ( 10 )   2057 - 2069   2017年10月

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    記述言語:英語   出版者・発行元:WILEY  

    Background: Most studies that examined risk factors for wound complications after head and neck reconstruction analyzed various complications collectively. Moreover, they included a wide variety of resection areas and reconstruction materials. To overcome these limitations, both the resection area and reconstruction method were constrained in the present study.
    Methods: Patients who underwent free jejunal graft reconstruction after pharyngolaryngoesophagectomy for hypopharyngeal cancer were enrolled. The outcomes of interest were abscesses, fistulas, and cervical skin flap necrosis.
    Results: Abscesses, fistulas, and cervical skin flap necrosis developed in 19.3%, 11.3%, and 8.2% of 773 patients, respectively. A significant relationship was found between use of an open drain and abscess formation and between a longer operation time and cervical skin flap necrosis.
    Conclusion: Our findings suggest that use of an open drain, cardiovascular disease, and a longer operation time are significant risk factors for abscess formation, fistula formation, and cervical skin flap necrosis, respectively.

    DOI: 10.1002/hed.24874

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  • 産業医活動に対する満足度と肥満・喫煙の関連性

    植嶋 一宗, 高尾 総司

    産業衛生学雑誌   59 ( 臨増 )   396 - 396   2017年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 分散事業場における円滑な事例対応のための工夫 事前相談シートの活用について

    友常 祐介, 平岡 晃, 岡部 花枝, 監物 友理, 高尾 総司

    産業衛生学雑誌   59 ( 臨増 )   470 - 470   2017年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Social Capital and Suicidal Ideation in Community-Dwelling Older Residents: A Multilevel Analysis of 10,094 Subjects in Japan

    Masayuki Noguchi, Tomoko Kobayashi, Toshihide Iwase, Etsuji Suzuki, Ichiro Kawachi, Soshi Takao

    AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY   25 ( 1 )   37 - 47   2017年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective: Social capital, the collective resources of groups including perceptions of trust and reciprocity, is recognized as an important contributor to suicide. We examined the association of individual-and community-level social capital with suicidal ideation after adjusting for social support among older adults living in the community. Methods: In August 2010 we sent questionnaires to all residents aged 65 years and older living in 3 rural municipalities (N = 21,232) in Okayama Prefecture, Japan; 13,919 questionnaires were returned (response rate: 65.6%). The final analysis included 10,094 participants. The outcome variable was suicidal ideation. Exposure variables were individual-level mistrust and lack of reciprocity (level 1), and the aggregated responses of these variables from 35 communities in the municipalities (level 2). Covariates included age, sex, educational attainment, marital status, the number of cohabitants, years of residence, self-rated socioeconomic status, disability, social support, and psychological distress. Multilevel logistic regression analysis was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Results: After adjusting for social support and psychological distress, we found that mistrust and lack of reciprocity were only associated with suicidal ideation at the individual level. Stratified analysis showed that among subjects with psychological distress, mistrust was associated with suicidal ideation at individual (OR: 1.88; 95% CI: 1.42-2.51) and community levels (OR: 1.98; 95% CI: 1.02-3.81). Conclusions: Our findings show that individual-and community-level social capital is a possible protective factor for suicidal ideation, particularly for people with psychological distress.

    DOI: 10.1016/j.jagp.2016.10.014

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  • Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Akira Minoura, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    ONCOLOGY   93 ( 3 )   204 - 212   2017年

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    記述言語:英語   出版者・発行元:KARGER  

    Objective: We aimed to determine the distribution of tumor-associated macrophages (TAMs) in the development of tongue squamous cell carcinoma (SCC) and to elucidate the role of TAMs in the progression of tongue SCC. Methods: The expression of the macrophage markers nitric oxide synthase, Retnla, and mannose receptor 1 in the development of tongue SCC was longitudinally observed using real-time quantitative polymerase chain reaction. Additionally, an immunohistochemical study using an anti-mannose receptor (MR) antibody was performed. Results: The numbers of both of M1 and M2 macrophages in the tongues of mice treated with 4-nitroquinoline-1-oxide (4NQO) were significantly lower compared with those of normal tongues. The cyclo-oxygenase-2 (COX-2) inhibitor did not prevent cancer progression and did not affect the total number of macrophages in the tongues of 4NQO-treated mice. In the immunohistochemical studies, MR staining was observed in lymphangio-endothelium in the subepithelial area of the tongues. The staining intensity of the MR was significantly stronger in the 4NQO-treated mice compared with that in control mice and 4NQO-treated mice treated with the COX-2 inhibitor. Conclusion: TAMs may not contribute to the development of 4NQO-induced tongue SCC. MR expression is associated with the progression of 4NQO-induced tongue SCC. (C) 2017 S. Karger AG, Basel

    DOI: 10.1159/000477301

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  • The role of bacteriological studies in the management of peritonsillar abscess

    Tomoyasu Tachibana, Yorihisa Orita, Soshi Takao, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Iku Fujisawa, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   120 ( 5 )   772 - 773   2017年

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    掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.3950/jibiinkoka.120.772

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  • 上司教育による労務管理的メンタルヘルス一次予防

    高尾総司

    日本職業・災害医学会会誌   65   2017年

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  • The role of bacteriological studies in the management of peritonsillar abscess

    Tomoyasu Tachibana, Yorihisa Orita, Soshi Takao, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Iku Abe-Fujisawa, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

    AURIS NASUS LARYNX   43 ( 6 )   648 - 653   2016年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI LTD  

    Objective: Since most patients with peritonsillar abscess (PTA) can be successfully treated with surgical drainage and empirical antibiotic therapy, routine bacteriologic studies for all patients with PTA may be unnecessary. This study tried to evaluate which patients with PTA should certainly undergo bacteriologic studies.
    Methods: Hundred consecutive patients with PTA were treated and underwent culture tests of purulent contents obtained by surgical drainage between April 2008 and December 2013.
    Results: In 62 of the 100 patients, 71 pathogenic bacteria were identified; 61 (86%) were Gram-positive cocci (GPC), 8 (11%) were Gram-negative rods (GNR), and 6 (8%) were anaerobes. Normal flora were isolated in 27 patients, and culture results were negative in 11 patients. Although not significant, primary (without prior antibiotic therapy) case (odds ratio (OR) = 2.19; 95% CI, 0.95-5.05) and laryngeal edema (OR = 2.04; 95% CI, 0.82-5.03) showed a tendency of associations with detection of pathogenic bacteria. After taking into account interactions between smoking habit and laryngeal edema, the covariate-adjusted OR for non-smokers with laryngeal edema was significant and showed a strong relationship (OR = 7.43; 95% confidence interval, 1.05-52.73) compared to non-smokers without laryngeal edema.
    Conclusion: Although empirical antibiotic therapy was effective for most of the PTA patients, bacteriologic studies might be indispensable for the patients with laryngeal edema considering the failure of the first treatments. Particularly, the culture tests may be useful for non-smokers with laryngeal edema. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.anl.2016.01.009

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  • Regulatory T cells function at the early stage of tumor progression in a mouse model of tongue squamous cell carcinoma

    Kentaro Miki, Yorihisa Orita, Yuka Gion, Soshi Takao, Kyotaro Ohno, Mai Takeuchi, Toshihiro Ito, Hiroyuki Hanakawa, Tomoyasu Tachibana, Hidenori Marunaka, Takuma Makino, Akira Minoura, Akihiro Matsukawa, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

    CANCER IMMUNOLOGY IMMUNOTHERAPY   65 ( 11 )   1401 - 1410   2016年11月

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    記述言語:英語   出版者・発行元:SPRINGER  

    The objective of this study was to observe the distribution of regulatory T cells (Tregs) in the development of tongue squamous cell carcinoma (SCC) and to determine the role of Tregs in the progression of tongue SCC. A mouse model of 4-nitroquinoline-1-oxide (4NQO)-induced-tongue SCC was established. The expression of Forkhead box P3 (Foxp3), interleukin 10, transforming growth factor-beta, chemokine CC motif ligands 17, 20, and CC chemokine receptor 4 was determined using real-time quantitative polymerase chain reaction. Foxp3 expression was also analyzed using immunohistochemistry. The results were compared with those of control mice and of 4NQO-treated mice treated with a cyclooxygenase-2 (COX-2) inhibitor. Well to moderately differentiated tongue SCC was induced in all of the experimental mice. The amount of Tregs of the experimental mice was over 10 times as much as control mice at the early stage of tumor progression. COX-2 inhibitor did not prevent the progression of tongue SCC and did not reduce the total amount of Tregs. Tregs function at the early stage of the development of tongue SCC, and it may be effective to suppress Tregs at the early stage of tumor progression for the treatment and/or prevention of tongue SCC.

    DOI: 10.1007/s00262-016-1902-x

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  • Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes

    Shinji Sakamoto, Manabu Takaki, Yuko Okahisa, Yutaka Mizuki, Masatoshi Inagaki, Hiroshi Ujike, Toshiharu Mitsuhashi, Soshi Takao, Masashi Ikeda, Yosuke Uchitomi, Nakao Iwata, Norihito Yamada

    JOURNAL OF HUMAN GENETICS   61 ( 4 )   329 - 334   2016年4月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Many patients with schizophrenia have poor clinical and social outcomes. Some risk alleles closely related to the onset of schizophrenia have been reported to be associated with their clinical phenotypes, but the direct relationship between genetic vulnerability to schizophrenia and clinical/social outcomes of schizophrenia, as evaluated by both practical clinical scales and 'real-world' function, has not been investigated. We evaluated the clinical and social outcomes of 455 Japanese patients with schizophrenia by severity of illness according to the Clinical Global Impression-Severity Scale (CGI-S) and social outcomes by social adjustment/maladjustment at 5 years after the first visit. We examined whether 46 single nucleotide polymorphisms (SNPs) selected from a Japanese genome-wide association study of susceptibility to schizophrenia were associated with clinical and social outcomes. We also investigated the polygenic risk scores of 46 SNPs. Allele-wise association analysis detected three SNPs, including rs2623659 in the CUB and Sushi multiple domains-1 (CSMD1) gene, associated with severity of illness at end point. The severity of illness at end point was associated with treatment response, but not with the severity of illness at baseline. Three SNPs, including rs2294424 in the C6orf105 gene, were associated with social outcomes. Point estimates of odds ratios showed positive relationships between polygenic risk scores and clinical/social outcomes; however, the results were not statistically significant. Because these results are exploratory, we need to replicate them with a larger sample in a future study.

    DOI: 10.1038/jhg.2015.153

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  • 記述統計の結果を報告する際の検定の扱いについて CONSORT 2010声明とSTROBE声明を踏まえて

    鈴木 越治, 三橋 利晴, 高尾 総司, 津田 敏秀

    産業衛生学雑誌   57 ( 臨増 )   466 - 466   2015年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Social support and suicidal ideation in Japan: are home visits by commissioned welfare volunteers associated with a lower risk of suicidal ideation among elderly people in the community? (vol 49, pg 619, 2014)

    Masayuki Noguchi, Toshihide Iwase, Etsuji Suzuki, Yoko Kishimoto, Soshi Takao

    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY   50 ( 3 )   505 - 506   2015年3月

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    記述言語:英語   出版者・発行元:SPRINGER HEIDELBERG  

    DOI: 10.1007/s00127-014-0967-0

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  • 地域の見守り体制を作る 吉備中央町におけるソーシャル・キャピタル育成の試み(事例へのコメント)

    高尾総司

    保健師ジャーナル   70 ( 5 )   422 - 422   2014年

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  • Industrial distributions of severe occupational injuries among workers in Thailand. 国際誌

    Michiyo Yamakawa, Pornchai Sithisarankul, Takashi Yorifuji, Sarunya Hengpraprom, Narin Hiransuthikul, Hiroyuki Doi, Soshi Takao

    Journal of occupational health   55 ( 5 )   415 - 21   2014年

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    記述言語:英語   出版者・発行元:WILEY  

    BACKGROUND: In industrializing countries, occupational safety and health have been affected by globalization. However, a lack of reliable data prevents evaluation of this situation. Therefore, we examined industrial distributions and risks of severe occupational injuries among workers in Thailand, which is one of the few industrializing countries that compiles nationwide data. METHODS: Data on workers who made claims for occupational injuries from 2007 to 2009 were extracted from the Workmen's Compensation Fund records in Thailand. Among 501,334 claimants, we evaluated the industrial distributions of severe occupational injuries (i.e., permanent disability and death). We then examined the associations between industry and those injuries, using proportionate ratios (PRs) between each industrial category and the overall distribution of occupational injuries. RESULTS: The number of workers in manufacturing making claims for severe occupational injuries was the largest among all industrial categories (319,114/501,334 injuries), although the total number of occupational injuries recently declined. Additionally, workers in manufacturing experienced severe occupational injuries more often compared with the overall distribution of occupational injuries. The PRs (95% confidence interval) for manufacturing were 1.17 (1.14-1.20) in men and 1.33 (1.27-1.38) in women. After adjusting for individual characteristics, the results did not substantially change. CONCLUSIONS: Manufacturing seems to have the largest burden of occupational injuries in industrializing countries like Thailand.

    DOI: 10.1539/joh.13-0085-FS

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  • 効果的な産業医研修会実施のための産業医意識実態調査-産業医研修会参加とメンタルヘルス実務に対する態度の関連について-

    高尾総司, 岸本卓巳

    産業衛生学雑誌   56   2014年

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  • 問題発生時におけるルール・業務遂行レベルにもとづくメンタル対応

    高尾総司

    月刊人事労務   ( 9 )   4 - 15   2013年

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  • Type D Personality Is Associated with Psychological Distress and Poor Self-Rated Health among the Elderly: A Population-Based Study in Japan.

    Kasai Y, Suzuki E, Iwase T, Doi H, Takao S

    PLoS One.   8 ( 10 )   e77918-e77918   2013年

  • 職場のソーシャル・キャピタルと健康に関するレビュー

    鈴木越治, OKSANEN Tuula, VAHTERA Jussi, VAHTERA Jussi, KIVIMAKI Mika, KIVIMAKI Mika, KIVIMAKI Mika, 高尾総司

    産業衛生学雑誌   55   2013年

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  • 「しごとと健康」34 安全衛生管理体制と企業買収

    高尾総司

    健康管理   60 ( 1 )   2013年

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  • Social cohesion and mortality: a survival analysis of older adults in Japan.

    Inoue S, Yorifuji T, Takao S, Doi H, Kawachi I

    Am J Public Health.   103 ( 12 )   e60-e66   2013年

  • 個人レベルソーシャルキャピタルと主観的不健康 リソースジェネレーターを用いて

    小林 朋子, 岩瀬 敏秀, 三橋 利晴, 高尾 総司, 鈴木 越治

    産業衛生学雑誌   54 ( 臨増 )   503 - 503   2012年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 日本人男性労働者における交替勤務と糖尿病の関連 不定期および常時交替勤務の比較

    井家 克彦, 鈴木 越治, 三橋 利晴, 小林 朋子, 高尾 総司

    産業衛生学雑誌   54 ( 臨増 )   444 - 444   2012年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 母親の労働時間と小児の過体重の関連 追加報告

    三橋 利晴, 鈴木 越治, 高尾 総司, 津田 敏秀, 土居 弘幸

    産業衛生学雑誌   54 ( 臨増 )   362 - 362   2012年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 考察「しごとと健康」 職場における健康情報の管理

    三橋 利晴, 高尾 総司

    健康管理   ( 694 )   42 - 43   2012年4月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • Do bonding and bridging social capital have differential effects on self-rated health? A community based study in Japan

    Iwase T, Suzuki E, Takao S, Doi H, Kawachi I

    J Epidemiol Community Health   66 ( 5 )   557 - 562   2012年

  • Social capital and self-rated oral health among young people.

    Michiko Furuta, Daisuke Ekuni, Soshi Takao, Etsuji Suzuki, Manabu Morita, Ichiro Kawachi

    Community Dentistry and Oral Epidemiology   40 ( 2 )   97 - 104   2012年

  • 考察「しごとと健康」 健康診断・事後措置の問題解決(5)

    高尾 総司, 三橋 利晴

    健康管理   ( 690 )   40 - 41   2011年12月

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    記述言語:日本語   出版者・発行元:(株)保健文化社  

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  • 交代勤務による糖尿病への影響

    井家 克彦, 鈴木 越治, 三橋 利晴, 小林 朋子, 高尾 総司

    産業衛生学雑誌   53 ( 臨増 )   470 - 470   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 日本の病院におけるソーシャル・ネットワークと看護師の主観的不健康

    岩瀬 敏秀, 三橋 利晴, 高尾 総司, 津田 敏秀, 土居 弘幸

    産業衛生学雑誌   53 ( 臨増 )   500 - 500   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 母親の就業時間と小児の肥満の関連

    三橋 利晴, 鈴木 越治, 高尾 総司, 津田 敏秀

    産業衛生学雑誌   53 ( 臨増 )   552 - 552   2011年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • しごとと健康(14)健康診断・事後措置のパラダイムシフト1

    高尾総司, 鈴木越治

    健康管理   ( 5 )   34 - 35   2011年

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  • 企業の健康管理体制と実施状況の関連 サンプリング方法による相違

    井家 克彦, 三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   611 - 611   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 岡山県における企業の健康管理体制と従業員による客観的評価

    小林 朋子, 岩瀬 敏秀, 三橋 利晴, 植嶋 一宗, 井家 克彦, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   612 - 612   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 日本の職場における安全衛生の取り組みと従業員の主観的不健康 岡山県働き盛りの健康支援のための実態調査

    岩瀬 敏秀, 三橋 利晴, 植嶋 一宗, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   613 - 613   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 産業医選任の有無と肥満と喫煙の関連性 ランダムサンプル群とコンビニエントサンプル群における対比

    植嶋 一宗, 岩瀬 敏秀, 三橋 利晴, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   614 - 614   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職場における安全衛生の取り組みと従業員の主観的健康 岡山県働き盛りの健康支援のための実態調査

    高尾 総司, 鈴木 越治, 三橋 利晴, 岩瀬 敏秀, 植嶋 一宗, 井家 克彦, 小林 朋子, 土居 弘幸

    産業衛生学雑誌   52 ( 臨増 )   612 - 612   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 企業の安全衛生管理について取り組みと従業員のBMIと喫煙割合の関連 岡山県働き盛りの健康支援のための実態調査

    三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 井家 克彦, 小林 朋子, 鈴木 越治, 高尾 総司

    産業衛生学雑誌   52 ( 臨増 )   613 - 613   2010年5月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Is There Any Association between TV Viewing and Obesity in Preschool Children in Japan?

    Sasaki A, Yorifuji T, Iwase T, Komatsu H, Takao S, Doi H

    Acta Med Okayama   64 ( 2 )   137 - 142   2010年

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  • Physical Activity and Mortality Risk in the Japanese Elderly A Cohort Study

    Kazumune Ueshima, Kazuko Ishikawa-Takata, Takashi Yorifuji, Etsuji Suzuki, Saori Kashima, Soshi Takao, Masumi Sugiyama, Toshiki Ohta, Hiroyuki Doi

    American Journal of Preventive Medicine   38 ( 4 )   410 - 418   2010年

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  • Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan

    Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Hiroyuki Doi, Masumi Sugiyama, Kazuko Ishikawa-Takata, Toshiki Ohta

    Occupational and Environmental Medicine   67 ( 2 )   111 - 117   2010年

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  • しごとと健康(9)復職の三要件

    高尾総司, 鈴木越治

    健康管理   ( 12 )   34 - 35   2010年

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  • しごとと健康(1)二つの健康管理

    高尾総司, 鈴木越治

    健康管理   ( 4 )   42 - 43   2010年

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  • Does social capital promote physical activity? A population-based study in Japan.

    Ueshima K, Fujiwara T, Takao S, Suzuki E, Iwase T, Doi H, Subramanian SV, Kawachi I

    PLoS One.   5 ( 8 )   2010年

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  • ソーシャル・キャピタルと健康に関する調査 リソースジェネレータ結果記述

    三橋 利晴, 岩瀬 敏秀, 高尾 総司, 浜田 淳, 松岡 宏明, 中瀬 克己, 則安 俊昭

    日本公衆衛生学会総会抄録集   68回   239 - 239   2009年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • ソーシャル・キャピタルと健康に関する調査

    岩瀬 敏秀, 三橋 利晴, 高尾 総司, 松岡 宏明, 中瀬 克己, 則安 俊昭, 土居 弘幸

    日本公衆衛生学会総会抄録集   68回   238 - 238   2009年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 職場におけるリスクマネジメントに基づく過重労働対策の構築

    高尾 総司, 鈴木 越治, 神里 英吾, 三橋 利晴, 植嶋 一宗, 岩瀬 敏秀, 土居 弘幸

    産業衛生学雑誌   51 ( 臨増 )   639 - 639   2009年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 岡山県の企業における健康管理と従業員の主観的健康

    三橋 利晴, 高尾 総司, 土居 弘幸

    産業衛生学雑誌   51 ( 臨増 )   453 - 453   2009年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • Total hair mercury content and neurological signs in Minamata and neighboring communities.

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    Epidemiology   in press   2009年

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  • Minamata Disease: Catastrophic Poisoning due to a failed public health response

    Tsuda T, Yorifuji T, Takao S, Miyai M, Babazono A

    Journal of Public Health Policy   30 ( 1 )   54 - 67   2009年

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    記述言語:英語   出版者・発行元:PALGRAVE MACMILLAN LTD  

    We present the history of Minamata disease in a chronological order from the public health point of view. Because the appropriate public health response - to investigate and control the outbreak - as set out in the Food Sanitation Act was not conducted, no one knew how many became ill following the outbreak. Exposure could not be stopped. In our discussion, we offer two reasons as to why the Japanese public health agencies did not apply the Act: social circumstances in the 1950s and 1960s that placed emphasis on industrial development, and the Japanese medical community's lack of knowledge about the Act. The history of Minamata disease shows us the consequences when public health responses are not implemented. Minamata disease should be an invaluable lesson for future public health responses.

    DOI: 10.1057/jphp.2008.30

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  • Work-based Social Networks and Health Status among Japanese Employees.

    Suzuki E, Takao S, Subramanian SV, Doi H, Kawachi I

    J Epidemiol Community Health   63   692 - 696   2009年

  • Policy Implications of Social Capital for the Japanese Social Security System

    Jun Hamada, Soshi Takao

    ACTA MEDICA OKAYAMA   62 ( 5 )   275 - 283   2008年10月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We discuss the concept of social capital, which has received much attention recently. Social capital is important for the following 2 key reasons: (1) a highly democratic polity and a strong economic performance that attaches great importance to the public good can be achieved on the basis of high social capital; and (2) social capital can effect health status in the human population, and widening of income inequality harms human health through the erosion of social capital. In addition, there are 3 political implications of social capital for Japanese society: (1) social capital has implications for the political decision of whether Japanese society should adopt a "medium burden for medium welfare" or a "low burden for small welfare" model together with the concept of social overhead capital; (2) reciprocity, which is one of the primary components of social capital, is similar to the philosophy underlying the health care system of Japan; (3) Japanese society needs to change from a society that emphasizes the relationships between its members to a society that is open to outsiders and has sufficient opportunities.

    DOI: 10.18926/AMO/30971

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  • 企業の健康管理方針と従業員の主観的健康およびBMIの関連

    三橋 利晴, 高尾 総司, 土居 弘幸

    日本公衆衛生学会総会抄録集   67回   625 - 625   2008年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

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  • 職域における適正飲酒プログラムとは?

    高尾総司

    肥満と糖尿病   7 ( 4 )   583 - 585   2008年

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  • Long-term exposure to methylmercury and neurological signs in Minamata and its neighboring communities: a population-based study

    Yorifuji T, Tsuda T, Takao S, Harada M

    Epidemiology   19 ( 1 )   1 - 2   2008年

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  • 職場におけるリスクマネジメントに基づく健診事後措置プログラムの開発と評価-2症例の試行結果の報告-

    高尾総司, 鈴木越治, 神里英吾, 小松裕和, 植嶋一宗, 岩瀬敏秀, 土居弘幸

    日本産業衛生学会講演集(CD-ROM)   81st   2008年

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  • Effects of an education program for stress reduction on supervisor knowledge, attitudes, and behavior in the workplace: A randomized controlled trial

    Kyoko Nishiuchi, Akizumi Tsutsumi, Soshi Takao, Sachiko Mineyama, Norito Kawakami

    JOURNAL OF OCCUPATIONAL HEALTH   49 ( 3 )   190 - 198   2007年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Supervisors at work play a large role in stress management at the workplace. Providing supervisors with necessary information and useful skills might be one effective approach that will lead to stress reduction. However, very few studies have investigated the effect of supervisor education by using a rigorous study design. In a randomized controlled trial, we tried to clarify how an education program for stress reduction influences supervisor knowledge, attitudes, and behavior concerning stress management. The subjects were 46 supervisors of an old, established sake brewery manufacturer of 301 employees. The supervisors were assigned to either the intervention group (24 supervisors) or the control group (22 supervisors). We conducted a single-session education program that included the guidelines for worker mental health promotion to the intervention group. The education program was composed of a basic education lecture and active listening training. The effects of this program on supervisor knowledge, attitudes, and behavior were measured using an original, self-administered questionnaire. The intervention effect was tested by examining an interaction effect between groups and time (before education, three and six months after education). The education favorably affected supervisor knowledge (F=7.92; p=.001). As for behavior, the intervention effect was marginally statistically significant (F=2.51; p=.088). For the attitude score, however, there were no beneficial effects. In conclusion, the provision of necessary information and useful skills to supervisors seems to improve supervisor knowledge and behavior regarding stress management at the workplace for at least six months.

    DOI: 10.1539/joh.49.190

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  • Supervisors’ attitudes and skills for active listening with regard to job stress and psychological stress reactions among subordinate workers.

    Mineyama S, Tsutsumi A, Takao S, Nishiuchi K, Kawakami N

    J Occup Health   49 ( 2 )   81 - 87   2007年3月

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  • The Health of Japanese -What Can We Learn From America?

    Kawachi I, Fujisawa Y, Takao S

    Journal of the National Institute of Public Health   56 ( 2 )   114 - 121   2007年

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  • Income Inequality and Population Health: Recent Clues Concerning Pathways and Mechanisms.

    Kawachi I, Fujisawa Y, Takao S

    保健医療社会学論集   18 ( 2 )   29 - 35   2007年

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  • 職場における適正飲酒の行動介入プログラムの開発と評価

    高尾総司

    日本アルコール関連問題学会雑誌   9   101 - 108   2007年

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  • Effects of the job stress education for supervisors on psychological distress and job performance among their immediate subordinates: A supervisor-based randomized controlled trial

    Soshi Takao, Akizumi Tsutsumi, Kyoko Nishiuchi, Sachiko Mineyama, Norito Kawakami

    Journal of Occupational Health   48 ( 6 )   494 - 503   2006年11月

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    記述言語:英語  

    As job stress is now one of the biggest health-related problems in the workplace, several education programs for supervisors have been conducted to reduce job stress. We conducted a supervisor-based randomized controlled trial to evaluate the effects of an education program on their subordinates' psychological distress and job performance. The subjects were 301 employees (46 supervisors and 255 subordinates) in a Japanese sake brewery. First, we randomly allocated supervisors to the education group (24 supervisors) and the waiting-list group (22 supervisors). Then, for the allocated supervisors we introduced a single-session, 60-min education program according to the guidelines for employee mental health promotion along with training that provided consulting skills combined with role-playing exercises. We conducted pre- and post-intervention (after 3 months) surveys for all subordinates to examine psychological distress and job performance. We defined the intervention group as those subordinates whose immediate supervisors received the education, and the control group was defined as those subordinates whose supervisors did not. To evaluate the effects, we employed a repeated measures analysis of variance (ANOVA). Overall, the intervention effects (time x group) were not significant for psychological distress or job performance among both male (p=0.456 and 0.252) and female (p=0.714 and 0.106) subordinates. However, young male subordinates engaged in white-collar occupations showed significant intervention effects for psychological distress (p=0.012) and job performance (p=0.029). In conclusion, our study indicated a possible beneficial effect of supervisor education on the psychological distress and job performance of subordinates. This effect may vary according to specific groups.

    DOI: 10.1539/joh.48.494

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  • わが国の企業におけるeラーニングとこれによる労働安全衛生教育の利用状況、ニーズおよび関連要因

    三橋 利晴, 高尾 総司, 堤 明純, 川上 憲人

    産業衛生学雑誌   48 ( 5 )   183 - 191   2006年9月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

    わが国の企業におけるeラーニングとこれによる労働安全衛生教育の利用状況、ニーズおよびその促進・阻害要因を明らかにするために、従業員1,000人以上と同999人以下の企業それぞれから500社を抽出し、質問票による調査を実施し、有効回答した合計134社(回答率13%、企業規模それぞれ56社、78社)のデータを分析した。全体で19%の企業がeラーニングを導入済み、さらに16%の企業が導入を検討中であった。しかしeラーニングによる労働安全衛生教育の実施は従業員1,000人以上の企業でも7%、999人以下の企業では3%未満と低かった。一方eラーニングによる労働安全衛生教育についてはどの対象者、コンテンツでも8〜9割の企業が受講させることを考えると回答していた。eラーニングの利点としては「いつでも受講できる」、「どこからでも受講できる」が、導入の問題点としては「コスト」、「パソコンが1人に1台ずつない」、「学習効果が不明確」であった。しかしeラーニングの導入済みあるいは検討中には、「受講状況が把握できる」が有意な関連を示した。「優良なコンテンツが得られない」という問題点は、eラーニング導入済み・検討中の企業に多かった。eラーニングによる労働安全衛生教育はまだ導入している企業は少ないが、そのニーズは高い。eラーニングおよびこれによる労働安全衛生教育の推進のために、eラーニングのシステムおよびコンテンツの改善、導入コストの低減、企業のeラーニング導入インフラの改善が必要と考えた。(著者抄録)

    DOI: 10.1539/sangyoeisei.48.183

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  • Young epidemiologists' attitude towards Personal Data Protection

    G Kobashi, T Hoshuyama, K Ohta, H Sugimori, Oki, I, H Kanda, M Naito, S Takao, A Tamakoshi

    JOURNAL OF EPIDEMIOLOGY   16 ( 2 )   90 - 92   2006年3月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:JAPAN EPIDEMIOLOGICAL ASSOC  

    DOI: 10.2188/jea.16.90

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  • Effects of web-based supervisor training on job stressors and psychological distress among workers: A workplace-based randomized controlled trial

    N Kawakami, S Takao, Y Kobayashi, A Tsutsumi

    JOURNAL OF OCCUPATIONAL HEALTH   48 ( 1 )   28 - 34   2006年1月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Using workplaces as a unit for randomization, a randomized controlled trial was conducted to determine the effects of web-based supervisor training on the subject of worksite mental health on job stressors, supervisor support and psychological distress among subordinate workers. A total of eight workplaces of a sales and service company were randomly assigned to either training workplaces or non-training workplaces. Supervisors (n=23) at the training workplaces participated in web-based self-learning training on worksite mental health; supervisors (n=23) at the nontraining workplaces did not. A total of 81 subordinate workers under the trained supervisors (the intervention group) and 108 subordinate workers under the nontrained supervisors (the control group) completed the Brief Job Stress Questionnaire (BJSQ) at baseline and at a three-month follow-up. No significant intervention effect was observed for any scale of the BJSQ measuring job stressors, supervisor or coworker support, or psychological distress among subordinate workers (p &gt; 0.05). The item score of work autonomy changed very little in the intervention group, while it decreased in the control group during the follow-up period, yielding a significant intervention effect (p=0.02). The item score for a friendly atmosphere in the workplace increased in the intervention group, while the score remained stable in the control group, yielding a significant intervention effect (p=0.02). While the present study failed to show any clear effect of the webbased training of supervisors on reduction of job stressors, it may be useful for maintaining worker autonomy and improving the friendliness of the worksite atmosphere.

    DOI: 10.1539/joh.48.28

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  • 適正飲酒プログラムの開発と試行.

    高尾総司

    日本アルコール精神医学雑誌   13,3-9?   2006年

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  • 過重労働による健康障害を防止するために〜「やらねばならない事」と「やらなくても良い事」をズバっと整理する〜

    高尾総司

    よぼういがく別冊   36,1-52   2006年

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  • 上司の傾聴的態度と部下に認知される仕事の特徴とストレス反応

    峰山 幸子, 堤 明純, 高尾 総司, 西内 恭子, 川上 憲人

    産業ストレス研究   13 ( 1 )   66 - 66   2005年12月

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    記述言語:日本語   出版者・発行元:日本産業ストレス学会  

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  • Effects of web-based supervisor training on supervisor support and psychological distress among workers: A randomized controlled trial

    N Kawakami, Y Kobayashi, S Takao, A Tsutsumi

    PREVENTIVE MEDICINE   41 ( 2 )   471 - 478   2005年8月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Background. A randomized controlled trial was conducted to determine the effects of web-based supervisor training on worksite mental health on supervisor support and psychological distress among subordinate workers.
    Methods. Section chiefs in a computer engineering company were randomly assigned to either a training group (n = 9) or a non-training group (n = 7). The section chiefs in the training group participated in web-based self-learning training on worksite mental health. A total of 92 subordinate workers under the trained section chiefs (the intervention group) and 84 subordinate workers under the untrained section chiefs (the control group) completed a questionnaire at baseline and a 3-month follow-up.
    Results. The score of supervisor support greatly decreased in the control group during the follow-up period, and the score changed very little in the intervention group, with a significant intervention effect (P = 0.032). This pattern was more pronounced for one particular item dealing with the extent to which a supervisor listens to personal problems of subordinate workers (the intervention effect, P = 0.012). No intervention effect was observed for the score measuring co-worker support, psychological distress, or other job stressors among subordinate workers (P &gt; 0.05).
    Conclusions. It is suggested that the web-based training of supervisors on worksite mental health is useful in improving, or at least maintaining, supervisor support among subordinate workers. (c) 2005 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ypmed.2005.01.001

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  • Effects of a supervisory education for positive mental health in the workplace: A quasi-experimental study

    A Tsutsumi, S Takao, S Mineyama, K Nishiuchi, H Komatsu, N Kawakami

    JOURNAL OF OCCUPATIONAL HEALTH   47 ( 3 )   226 - 235   2005年5月

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    記述言語:英語   出版者・発行元:JAPAN SOC OCCUPATIONAL HEALTH  

    Single-session supervisory education was developed in conjunction with the Japanese national guidelines for the promotion of employee mental health. Totally 267 voluntary supervisors in a prefectural office were presented with comprehensive information on the role they had to fulfill to promote mental health in the workplace. Totally 864 office employees (53%) were evaluated to determine whether education had had an effect on their psychological distress and job performance. The findings from the departments in which more than one-third of the supervisors had attended education were compared to those from the departments in which no more than one-third of the supervisors had attended education. Three months after the education, the levels of psychological distress and, to a lesser extent, self-reported job performance improved among employees in the departments in which at least one-third of the supervisors attended the education compared to those from departments with lower attendance rates of the supervisors. For the psychological outcome, the positive educational effect was supported by statistically significant interaction terms between time and department category with adjustment for the confounders. Favorable changes were noted among supervisors who received the education in knowledge, attitude, and behavior regarding mental health practices. The behavioral changes were related to decreasing workplace problems and referral of employees to the liaison off ice and associated medical institutions. Despite several limitations, the findings suggest that providing supervisors with appropriate information has a positive effect on employee psychological well-being.

    DOI: 10.1539/joh.47.226

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  • P3023 職場における適正飲酒の行動介入プログラムの開発と評価 : 無作為化比較試験の途中経過

    高尾 総司, 三橋 利晴, 川上 憲人, 山津 幸司, 足達 淑子

    産業衛生学雑誌   47 ( 0 )   2005年4月

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    記述言語:日本語   出版者・発行元:公益社団法人日本産業衛生学会  

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  • D220 eラーニングによる労働安全衛生教育に関するニーズ・課題調査

    三橋 利晴, 高尾 総司, 川上 憲人, 堤 明純

    産業衛生学雑誌   47 ( 0 )   2005年4月

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    記述言語:日本語   出版者・発行元:公益社団法人日本産業衛生学会  

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  • Clostridium perfringens foodborne outbreak due to braised chop suey supplied by chafing dish

    H Ochiai, T Ohtsu, T Tsuda, H Kagawa, T Kawashita, S Takao, A Tsutsumi, N Kawakami

    ACTA MEDICA OKAYAMA   59 ( 1 )   27 - 32   2005年2月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    On February 13, 2002, a public health center in Hiroshima Prefecture, Japan, was notified that many individuals living at the Japan Maritime Self-Defence Force base had symptoms resembling those of food poisoning. Self-administered questionnaires requesting information regarding meal consumption and symptoms were distributed to all 281 members at the base. A case of the illness was defined as a member who had had watery or mucousy stool, or loose stool with abdominal cramps, more than twice a day after consuming dinner on February 12. Control of the illness was defined as a member with no symptoms. The dinner on February 12 was significantly associated with the illness (Mantel-Haenszel odds ratio: 3.59, 95% confidence interval: 1.06-12.20). A case-control study showed that, among the food supplied at dinner on February 12, the braised chop suey was significantly associated with the illness (odds ratio: 12.30, 95% confidence interval: 1.90-521.00). The braised chop suey had been stored in a chafing dish. An environmental investigation indicated that Clostridium perfringens (C. perfringens) in the chafing dish proliferated under an inappropriate heat-retention temperature, and the contaminated braised chop suey could have caused the food poisoning. This study demonstrated that the recommended heat-retention temperature (over 65 degreesC) should be confirmed thoroughly.

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  • 「社会疫学(Social Epidemiogy)の集い」のまとめ-第63回公衆衛生学会自由集会より-

    高尾総司

    日本健康教育学会ニュースレター   42,1-2   2005年

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  • 人を対象とした黒豆エキス含有クエン酸飲料の健康増進効果の評価

    落合裕隆, 谷口敏代, 児玉とも江, 藤原恭子, 高尾総司, 川上憲人

    日本公衆衛生学会総会抄録集   63rd   864   2004年10月

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  • ウエルシュ菌による食中毒アウトブレイク事例についての疫学調査

    落合裕隆, 大津忠弘, 香川治子, 河下寿昭, 津田敏秀, 高尾総司, 堤明純, 中瀬克己, 川上憲人

    日本衛生学雑誌   59 ( 2 )   146   2004年3月

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  • 小学校で発生した麻疹集団感染事例

    大津忠弘, 万代素子, 二宮忠矢, 松下明, 高尾総司, 落合裕隆, 津田敏秀, 中瀬克己

    日本衛生学雑誌   59 ( 2 )   145   2004年3月

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  • What expectations do young Japanese epidemiologists have for the future of epidemiology? A questionnaire survey of members of the young epidemiologists society for discussing the future of epidemiology.

    Gen Kobashi, Tsutomu Hoshuyama, Hiroki Sugimori, Izumi Oki, Takashi Kadowaki, Hideyuki Kanda, Tetsuya Otani, Motoki Iwasaki, Mariko Naito, Soshi Takao

    Journal of epidemiology   14 ( 2 )   69 - 71   2004年3月

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  • Eラーニングによる管理監督者向けメンタルヘルス教育の部下のストレス軽減に対する効果 無作為化比較試験

    川上 憲人, 小林 由佳, 高尾 総司, 堤 明純

    産業衛生学雑誌   46 ( 臨増 )   325 - 325   2004年3月

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    記述言語:日本語   出版者・発行元:(公社)日本産業衛生学会  

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  • 職位と身体活動量

    高尾総司, 川上憲人

    産業医学ジャーナル   2004年

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  • Occupational class and physical activity among Japanese employees

    S Takao, N Kawakami, T Ohtsu

    SOCIAL SCIENCE & MEDICINE   57 ( 12 )   2281 - 2289   2003年12月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined the distribution of physical activity among different occupations in Japan. A questionnaire was sent to full-time employees at nine companies in Japan between 1996 and 1998, with an average response rate of 85.2%. Data from 20,654 respondents (17,637 male and 3017 female) were analyzed. We classified the occupations into eight groups according to the International Standard Classification of Occupations (1988). Daily energy expenditure, weekly physical activity, and monthly leisure-time physical activity (LTPA) were measured using a physical activity questionnaire and some additional questions. In males, LTPA was significantly different among occupations, with clerks having greater physical activity than managers and blue-collar workers (P&lt;0.001). The pattern was similar even after adjusting for education, age, and working hours. In females, the difference among occupations was not clear. The distribution of LTPA among occupations exhibits a "barrel-shape" in Japan. It was higher for intermediate class occupations such as clerks, which was in agreement with a lower coronary heart disease mortality observed in intermediate class occupations among Japanese male employees. (C) 2003 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0277-9536(03)00134-5

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  • 福山市における麻疹流行と予防接種実施状況について 第1報・その1

    吉井健哲, 大津忠弘, 田中知徳, 高尾総司, 落合裕隆, 谷原真一, 津田敏秀, 中瀬克己

    日本公衆衛生学会総会抄録集   62nd   818   2003年10月

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  • 福山市における麻疹流行と予防接種実施状況について 第1報・その2

    大津忠弘, 吉井健哲, 田中知徳, 高尾総司, 落合裕隆, 谷原真一, 津田敏秀, 中瀬克己

    日本公衆衛生学会総会抄録集   62nd   818   2003年10月

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  • 職業性ストレスの職場平均と職場内格差が労働者の抑うつに与える影響 : マルチレベル分析

    川上 憲人, 堤 明純, 高尾 総司, 原谷 隆史

    産業衛生学雑誌 = Journal of occupational health   45   2003年3月

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  • 職業がんとイニシエーター・プロモーター

    津田 敏秀, 大津 忠弘, 高尾 総司, 茂見 潤, 馬場園 明, 三野 善央

    産業衛生学雑誌 = Journal of occupational health   45   603 - 603   2003年3月

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  • P329禁煙支援・事例報告 その1

    高尾 総司, 大津 忠弘, 太田 充彦, 茂見 潤, 津田 敏秀, 堤 明純, 三野 善央, 川上 憲人

    産業衛生学雑誌   44 ( 0 )   2002年3月

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    記述言語:日本語   出版者・発行元:公益社団法人日本産業衛生学会  

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  • カラーを用いた健康教育の可能性

    高尾 総司

    日本健康教育学会NEWSLETTER   30,1-2   2002年

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  • 禁煙支援・事例報告 その2

    大津忠弘, 高尾総司, 太田充彦, 茂見潤, 津田敏秀, 堤明純, 三野善央, 川上憲人

    産業衛生学雑誌   44   2002年

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  • 喫煙とメンタルヘルスとの関連について-職域における調査より-

    大津忠弘, 三野善央, 茂見 潤, 太田充彦, 高尾総司, 津田敏秀, 安田誠史, 馬場園 明, 山本英二, 青山英康

    健康開発   2001年

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  • 嘱託産業医の楽しみ-臨床医から紹介状をいただいた事例-

    高尾総司

    産業医活動報告集   2001年

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  • 職場のメンタルヘルス-産業医の有効的活用-

    高尾総司

    日本健康教育学会NEWSLETTER   26,1-2   2001年

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  • 地球における産業保健指導の展開

    高尾 総司, 工藤 葉子, 山本 裕美, 清龍 聡, 石田 高男, 青山 英康

    産業衛生学雑誌 = Journal of occupational health   42   194 - 194   2000年3月

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共同研究・競争的資金等の研究

  • 人工知能を活用したメンタル休職者に対する復職判定面談支援システムの開発

    研究課題/領域番号:21K10446  2021年04月 - 2024年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    高尾 総司, 頼藤 貴志

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    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

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  • 地域・職域連携による橋渡し型ソーシャル・キャピタル醸成の評価に関する基礎的研究

    研究課題/領域番号:16K09098  2016年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    高尾 総司

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    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    「地域・職域連携の指標」として、一般化信頼に加えて、「村内」と「他市町村」の人への信頼の「ギャップ(不一致)」を考えた。具体的には、「一般的には信頼するのに、他市町村の人は信頼しない」というような回答が相当する。この「ギャップ」を曝露として、年齢、性別、主観的SES(Socioeconomic Status)、一般化信頼を調整した、主観的不健康(poor SRH; Self-rated health)およびK6を用いた心理的苦痛(K6>13)の、オッズ比と95%信頼区間は、それぞれ2.63(1.04-6.61)、2.50(0.59-10.56)であった。

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  • 職場のソーシャル・キャピタル醸成を目的とした介入評価および発展的活用の基盤整備

    研究課題/領域番号:25460802  2013年04月 - 2016年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    高尾 総司, 谷原 真一, 浜田 淳

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    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    本研究では、企業における運動イベントの機会を介入とみなし、ソーシャル・キャピタル(SC)が醸成されるかどうかを評価した。なお、対照群の設定が困難であったことから、デザイン上の工夫を行い、擬似的に比較を行った。結果の概要は、天井効果により運動イベントへの参加に伴う明確なSC醸成は観察できなかった。基盤整備に関しては、フィンランドの公務員コホートとのデータ・ハーモナイズ等について研究者間で意見交換した。

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  • ソーシャル・キャピタルを用いたメタボ対策等行政施策評価に関する実証的研究

    研究課題/領域番号:21790582  2009年 - 2011年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    高尾 総司, 谷原 真一, 中谷 友樹, 浜田 淳

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    配分額:3770000円 ( 直接経費:2900000円 、 間接経費:870000円 )

    特定保健指導のような保健施策の効果評価は容易でない。本研究は、ソーシャル・キャピタル(SC)を指標とした施策評価を目的とした。既存データ解析から、SCを結合型と橋渡し型に分けて測定する意義が示唆された。横断調査の結果、愛育委員等による声かけが有意に希死念慮を減少させることが示唆され、地域における声かけを行う小規模な介入を予定したが、東日本大震災に伴う計画の遅れから、企業における運動介入評価を実施した。

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  • ミクロデータを用いた健康水準の地理的格差に関する実証的解析

    研究課題/領域番号:20300297  2008年 - 2010年

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    中谷 友樹, 松田 亮三, 藤澤 由和, 濱野 強, 高尾 総司, 埴淵 知哉

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    配分額:17420000円 ( 直接経費:13400000円 、 間接経費:4020000円 )

    本研究は、地理情報システムや空間統計学的解析、マルチレベル分析、ジオデモグラフィクスなどの地理的分析方法論を、個人を単位としたミクロデータ資料に適用し、日本の大都市圏に存在する近隣地区(町丁字)レベルの健康の地理的格差の実態把握とこれを既定する要因の解明を目的とした。その結果、所得水準などの社会経済的水準の居住者構成のみならず、ソーシャル・キャピタルや安全性、歩きやすさなど居住地域の社会・建造環境も健康の地理的格差の形成に寄与しており、健康水準は大都市圏の微細な居住地帯(社会地区)分化と関連して構造化されていることが明らかとなった。所得水準などで把握される貧困・剥奪の集中を減じる対応とともに、健康に寄与する環境づくりの重要性が示唆された。

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  • 急性アルコール中毒防止のための若年者向け適正飲酒プログラムの開発および効果評価

    研究課題/領域番号:17790385  2005年 - 2007年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    高尾 総司

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    配分額:2500000円 ( 直接経費:2500000円 )

    急性アルコール中毒防止のための若年者向け適正飲酒プログラムの開発および効果評価を目的として、若年者(大学生等)向けの飲酒プログラムのレビュー、若年者がイッキ飲みに至る社会的、個人的要因を明らかにするための小規模な疫学調査、プログラムの試作・試行、等を実施した。
    1.若年者向けの既存の飲酒に対する介入方法として、Harvard University School of Public Healthにおいて実施されたCollege Alcohol Study(CAS)などを参考に検討した。CASでは、大学キャンパス内や近隣における飲酒関連ポリシーの厳格化(例;学生寮での飲酒禁止、近隣居酒屋での飲み放題提供の禁止)などが中心であり、基本的には本プログラムの趣旨には合いにくいものであった。
    2.大学生を対象に若年者がイッキ飲みに至る要因を明らかにするための疫学調査を実施した。調査前に大学生・大学院生を対象に要因の絞り込みを行うためにインタビューを実施したが、外部要因として「部活の(後輩に飲ませる)先輩」が挙げられるなど、本人への介入だけでは対処しにくい点もあった。調査結果として、これまで研究者らが対象としてきた中高年男性とは大きく異なる特性が明らかとなった。特に、中高年男性においては、飲酒量などの面において周囲から問題飲酒の予備群であろうと指摘を受ける当該対象者自身に、いくらかでも自身の飲酒を改善したい、改善しようという認識があったのに対し、若年者においては、本プログラムが対象とするような危険な飲酒の予備群(binge drinkingのあるもの、など)と考えられる対象者には、そもそも飲酒を改善したいとの認識が少なかった。
    3.したがって、中高年男性に対するプログラムでは飲酒のプラス面に焦点をあてることで希望による対象者募集が可能であったが、若年者に対するプログラムでは、募集することが容易ではなく、プログラムの試作に基づき、試行を実施したが、CASのような強制的な方法との併用により提供する必要性もあると考えられた。

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  • 職業性ストレスとがん罹患の関連性およびそのメカニズムに関する疫学的研究

    研究課題/領域番号:16390170  2004年 - 2007年

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    川上 憲人, 堤 明純, 島津 明人, 廣川 空美, 高尾 総司, 津田 敏秀, 中田 光紀

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    配分額:15130000円 ( 直接経費:14500000円 、 間接経費:630000円 )

    本研究では、職業性ストレスとがん罹患との関連性とそのメカニズムを明らかにすることを目的として、2つの前向きコホート研究(既存コホートデータと新規コホート)および職業性ストレスとがん罹患の媒介要因(免疫機能、抗酸化能などの生理指標および食事等のがん関連保健行動)との関係についての小規模な追跡研究を実施した。
    特に本研究では以下の3点を検討した。(1)2大職業性ストレス理論である「要求度-コントロール-社会的支援モデル」および「努カ-報酬不均衡モデル」に基づく職業性ストレスと全がんの罹患(および部位別のがん罹患)との関連性、(2)これ以外の職場の社会心理的な要因とがん罹患との関連性、(3)職業性ストレスとがん関連の生理指標(免疫機能および抗酸化能マーカー)および保健行動(喫煙、飲酒、栄養)との関連性。
    結果として、職業性ストレスは全がんの罹患リスクを増加させる可能性があることが示唆された。そのメカニズムの一部として、職業性ストレスによるDNA酸化があると考えられた。一方、食事や生活習慣は、職業性ストレスとがん罹患をつなぐ媒介変数としては大きな役割を果たしていないと推測された。

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  • ITを用いた耐糖能異常者に対する効果的健康教育法の開発およびその効果評価

    研究課題/領域番号:14770169  2002年 - 2004年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    高尾 総司

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    配分額:2600000円 ( 直接経費:2600000円 )

    ITを用いた耐糖能異常者に対する効果的な健康教育法の開発および効果評価を目的として,(1)健康教育法のレビュー,(2)webページを用いたコンテンツの試作,(3)試作コンテンツを用いたIT健康教育法の試行,を実施した.
    (1)これまでの健康教育法の内容の中心は,(1)食事,(2)運動,(3)減量,(4)飲酒の4領域であった.(1)〜(3)については,完成度の高い教材がそろっており,そのまま活用可能であった.しかし,(4)については質の高い教材が見あたらず,新たに飲酒に関するコンテンツ作成行った.
    (2)双方向性の特徴を活かし,知識を提供するだけでなく,記録表を送信したり,参加者同士が意見交換したりできるwebページの試作を行った.しかし,webページへのアクセスをユーザーIDとパスワードで制限したとしても,サーバー内に保管した個人情報を悪意のある第三者に悪用されることを防ぐこと等が技術的に困難であり,このため試作したコンテンツを公開しての試行は見送った.
    (3)いつでもweb化できるよう意識してコンテンツ制作を行ったが,試行においては,紙ベースの教材,又は電子メール(添付ファイル)を用いて行った.今回は,飲酒量をコントロールするためのコンテンツを無作為化比較試験のデザインで効果評価した.対象は企業に勤務する社員121名(8社)であり,割付は個人単位ではなく,5名程度のグループ単位で行った.10名を除外し,111名(介入群56名,対照群55名)についてrepeated measures ANOVAで解析を行った.介入群の1日当たりの飲酒量は純アルコール64.3gから57.3gに,対照群も54.6gから46.8gに有意(群内(介入前後)F値8.3(p=0.005))に減少した.interaction項はF値0.02(p=0.883)であり,有意な介入効果を認めなかった.

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  • 一般住民の精神健康に関する社会・心理・生理・分子遺伝疫学的研究

    研究課題/領域番号:13470082  2001年 - 2003年

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    川上 憲人, 大津 忠弘, 津田 敏秀, 堤 明純, 尾崎 紀夫, 高尾 総司, 三野 善央

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    配分額:13500000円 ( 直接経費:13500000円 )

    平成13〜14年度には、調査票日本語版の訳語の確認と本調査用面接用プログラム(CAPI)の準備、面接員トレーニングの実施、データの収集とクリーニングを行った。岡山市住民から無作為に抽出したサンプル(1607名)に対して調査依頼し、27名の面接員が最終的に925名に面接を実施した(転居、死亡など調査対象外の者を除く回収率66%)。岡山市におけるDSM-IVおよびICD-10診断基準による主要な精神障害の有病率では、大うつ病(うつ病)、特定の恐怖症、アルコール乱用が比較的多く、うつ病(DSM-IV大うつ病、ICD-10うつ病エピソード)はこれまでに7〜8%の者が、過去12ヶ月間に2.5-2.6%の者がこれを経験していた。平成15年7月3〜10日には世界精神保健調査研究者会議(フランス)に出席し、面接調査データの予備的な解析結果を報告し、解析計画について専門家のレビューを受けるとともに、研究打ち合わせを行った。
    平成15年度には、上記面接調査への回答者から精神障害該当者及び非該当者(1/3の確率で選ばれた者)からそれぞれ採血および生理心理学的調査の対象者合計260名を選び、調査への参加を依頼し、同意した者について採血と生理心理学的測定を実施した。この調査は岡山大学医学部ヒトゲノム・遺伝子解析研究倫理審査委員会で承認された手続きにより書面で同意を得た上で実施された。全血サンプルは一時岡山大学に凍結保存した後、藤田保健衛生大に搬送され、遺伝マーカーの測定を行った。精神障害および自殺行動に影響する社会心理的要因の解析、社会機能およびQOLを含む社会心理的要因の解析、職業性因子の解析を実施した。また遺伝マーカーおよび生理学的要因と精神障害との関連性を解析した。

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担当授業科目

  • 医学データサイエンス (2021年度) 特別  - その他

  • 基礎統計学 (2021年度) 特別  - その他

  • 環境・産業保健論 (2021年度) 特別  - その他

  • 生物統計学基礎論 (2021年度) 特別  - その他

  • 疫学・衛生学実習 (2021年度) 特別  - その他

  • 疫学・衛生学I(演習・実習) (2021年度) 特別  - その他

  • 疫学・衛生学I(講義・演習) (2021年度) 特別  - その他

  • 疫学・衛生学II(演習・実習) (2021年度) 特別  - その他

  • 疫学・衛生学II(講義・演習) (2021年度) 特別  - その他

  • 疫学統計分析・演習Ⅰ (2021年度) 特別  - その他

  • 疫学統計分析・演習Ⅱ (2021年度) 特別  - その他

  • 研究方法論応用 (2021年度) 特別  - その他

  • 社会医歯科学 (2021年度) 集中  - その他

  • 社会疫学特論 (2021年度) 特別  - その他

  • 社会疫学(応用) (2021年度) 特別  - その他

  • 衛生学 (2021年度) 特別  - その他

  • 医学データサイエンス (2020年度) 特別  - その他

  • 医療倫理・臨床倫理特論 (2020年度) 特別  - その他

  • 基礎統計学 (2020年度) 特別  - その他

  • 環境・産業保健論 (2020年度) 特別  - その他

  • 生物統計学基礎論 (2020年度) 特別  - その他

  • 疫学・衛生学実習 (2020年度) 特別  - その他

  • 疫学・衛生学I(演習・実習) (2020年度) 特別  - その他

  • 疫学・衛生学I(講義・演習) (2020年度) 特別  - その他

  • 疫学・衛生学II(演習・実習) (2020年度) 特別  - その他

  • 疫学・衛生学II(講義・演習) (2020年度) 特別  - その他

  • 疫学分析・演習Ⅱ (2020年度) 特別  - その他

  • 社会医歯科学 (2020年度) 集中  - その他

  • 社会疫学特論 (2020年度) 特別  - その他

  • 社会疫学(応用) (2020年度) 特別  - その他

  • 衛生学 (2020年度) 特別  - その他

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