2024/12/19 更新

写真a

ニシオカ ヒロミ
西岡 弘美
NISHIOKA Hiromi
所属
医歯薬学域 助手
職名
助手
外部リンク

学位

  • 薬学博士 ( 岡山大学 )

研究キーワード

  • 有機化学

  • Synthetic Chemistry

  • Organic Chemistry

  • 合成化学

研究分野

  • ライフサイエンス / 薬系化学、創薬科学

学歴

  • 岡山大学   Faculty of Pharmaceutical Science  

    - 1992年

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  • 岡山大学   Faculty of Pharmaceutical Sciences  

    - 1992年

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    国名: 日本国

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経歴

  • 岡山大学   学術研究院医歯薬学域   助手

    2022年4月 - 現在

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  • 岡山大学   学術研究院医歯薬学域   助教

    2021年4月 - 2022年3月

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  • 岡山大学   医歯薬学総合研究科   助教

    2004年4月 - 2021年3月

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  • - Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2004年

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所属学協会

 

論文

  • Competitive binding assay with an umbelliferone-based fluorescent rexinoid for retinoid X receptor ligand screening 査読

    Shoya Yamada, Mayu Kawasaki, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Maho Takioku, Hiromi Nishioka, Yasuo Takeuchi, Makoto Makishima, Tomoharu Motoyama, Sohei Ito, Hiroaki Tokiwa, Shogo Nakano, Hiroki Kakuta

    Journal of Medicinal Chemistry   62 ( 19 )   8809 - 8818   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.jmedchem.9b00995

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  • Correction to Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Tri 査読

    Shibahara O, Watanabe M, Takamura Y, Yamada S, Akehi M, Sasaki T, Akahoshi A, Hanada T, Hirano H, Nakatani S, Nishioka H, Takeuchi Y, Kakuta H

    Journal of medicinal chemistry   62 ( 9 )   4780 - 4781   2019年5月

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  • Structure-activity relationship of indoloquinoline analogs anti-MRSA 査読

    Zhao M, Kamada T, Takeuchi A, Nishioka H, Kuroda T, Takeuchi Y

    Bioorg. Med. Chem. Lett.   25   5551 - 5554   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Palladium-catalyzed hydrogenation with use of ionic liquid bis(2-hydroxyethyl)ammonium formate [BHEA][HCO2] as a solvent and hydrogen source 査読

    Hideyuki Suzuki, Seiki Yoshioka, Ami Igesaka, Hiromi Nishioka, Yasuo Takeuchi

    TETRAHEDRON   69 ( 31 )   6399 - 6403   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We designed ionic liquid bis(2-hydroxyethyl)ammonium formate [BHEA][HCO2] for use as a solvent and hydrogen donor for hydrogenation. Catalytic hydrogenation of aromatic ketones, nitro groups, and olefins with PdCl2 in [BHEA][HCO2] generated the corresponding reduction products. Selective reduction of aromatic ketones over aliphatic ketones was observed. Hydrogenolysis of benzyl ethers and benzyl amines also proceeded. All these reactions were successfully carried out in good to excellent yields under mild and nonflammable conditions. In addition, the ionic liquid and Pd source can be reused several times. (C) 2013 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tet.2013.05.103

    Web of Science

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  • Non-flammable and reusable hydrogenation of aromatic ketones in ionic liquid 査読

    Hideyuki Suzuki, Hiromi Nishioka, Yasuo Takeuchi

    TETRAHEDRON LETTERS   53 ( 28 )   3686 - 3688   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    A novel method of hydrogenation of aromatic ketones in the ionic liquid [BHEA][HCO2] was developed; this method is more enhanced in terms of flammability and reusability as compared to the conventional method (H-2 and Pd/C). The reductive selectivities of aromatic and aliphatic ketones in this method were observed. (C) 2012 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tetlet.2012.05.066

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MISC

  • Controlled hydrogenation of diphenylacetylene using alkylammonium formate

    Hideyuki Suzuki, Ikkyu Satoh, Hiromi Nishioka, Yasuo Takeuchi

    TETRAHEDRON LETTERS   58 ( 40 )   3834 - 3837   2017年10月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    A simple and straightforward semihydrogenation of alkyne to alkene with triethanolamine and formic acid in the presence of PdCl2 has been described. Although hydrogenation using formic acid as a hydrogenation source has been used in combination with amines previously, few reports are available concerning the associated reactivity. We demonstrated that reactivity changes depending on the type of amine used in the hydrogenation. Further, this reaction requires no strict time control, making it a useful tool in organic synthesis. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tetlet.2017.08.054

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  • Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imagin・・・

    Osamu Shibahara, Masaki Watanabe, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Hiroyuki Hirano, Shunsuke Nakatani, Hiromi Nishioka, Yasuo Takeuchi, Hiroki Kakuta

    Journal of Medicinal Chemistry, Journal of Medicinal and Pharmaceutical Chemistry   60 ( 16 )   7139 - 7145   2017年8月

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    記述言語:英語  

    Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof

    DOI: 10.1021/acs.jmedchem.7b00817

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  • Synthesis and Anti-human Immunodeficiency Virus Activity of the Skeleton Isomers of 3H,4H-Di-(O)-(−)-camphanoyl-(+)-khellactone

    Nishioka H, Uesugi K, Ueda N, Kondo Y, Tsuji M, Abe H, Harayama T, Hamasaki T, Baba M, Takeuchi Y

    Chem. Pharm. Bull.   59 ( 8 )   1075 - 1076   2011年8月

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  • Synthesis of (-)-Actinonin

    Shin-ichi Inoue, Hiromi Nishioka, Hitoshi Abe, Takashi Harayama, Yasuo Takeuchi

    SYNTHESIS-STUTTGART   2011 ( 11 )   1705 - 1710   2011年6月

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    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent.

    DOI: 10.1055/s-0030-1260461

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  • Synthesis of acinetobactin

    Yasuo Takeuchi, Satoru Ozaki, Masahiro Satoh, Ken-Ichiro Mimura, Sei-Ichi Hara, Hitoshi Abe, Hiromi Nishioka, Takashi Harayama

    Chemical and Pharmaceutical Bulletin   58 ( 11 )   1552 - 1553   2010年11月

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    記述言語:英語  

    A structure involving the absolute configuration of acinetobactin (1b) was clarified. It was reconfirmed that preacinetobactin (1a) produced 1b by a rearrangement reaction. © 2010 Pharmaceutical Society of Japan.

    DOI: 10.1248/cpb.58.1552

    Scopus

    PubMed

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講演・口頭発表等

  • Pd反応系を用いたビアリール閉環反応における有機塩基の影響

    日本薬学会第124年会  2004年 

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  • Wittig 試薬を用いた Coumarin 環形成反応における酸素官能基の影響

    第39回日本薬学会・日本病院薬剤師会中国四国支部学術大会  2000年 

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担当授業科目

  • 化学系基礎実習 (2024年度) 1・2学期  - その他5~9

  • 化学系基礎実習 (2024年度) 1・2学期  - その他5~9

  • 臨床準備教育C (2024年度) 特別  - その他

  • 薬学基本実習 (2024年度) 第1学期  - その他5~9

  • 薬学基本実習 (2024年度) 第1学期  - その他5~9

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