Updated on 2024/11/06

写真a

 
TERATO Hiroaki
 
Organization
Advanced Science Research Center Professor
Position
Professor
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Degree

  • PhD ( Hiroshima University )

Research Interests

  • 酸化損傷

  • DNA修復酵素

  • 放射線抵抗性

  • DNA

  • 塩基損傷

  • 脱アミノ化

  • ストレス応答

  • 付加体形成

  • 塩基対合

  • Endo VIII

  • シッフ塩基

  • 損傷乗り越え複製

  • 修復酵素

  • タンパク誘導

  • DNA修復

  • オキザニン

  • 塩基除去修復

  • 活性酸素

  • チミングリコール

  • ヌクレオチド除去修復

  • 放射線

  • Endo III

  • DNA複製

  • 突然変異

  • ヒストン

  • DNAグリコシラーゼ

  • クロスリンク

  • 窒素酸化物

  • DNA損傷

  • 放射線照射の影響 環境因子の生物に対する影響 酵素学 核酸の生化学

  • Influence of radiation exposure(=irradiation) Influence of environmental factors on organism Enzymology Biochemistry of nucleic acids

  • 一酸化窒素

Research Areas

  • Environmental Science/Agriculture Science / Chemical substance influence on environment

  • Environmental Science/Agriculture Science / Radiation influence

  • Environmental Science/Agriculture Science / Environmental impact assessment

  • Life Science / Molecular biology

  • Environmental Science/Agriculture Science / Environmental policy and social systems

Education

  • Kochi University   理学研究科   生物学

    1987.4 - 1989.3

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    Country: Japan

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  • Kochi University    

    - 1989

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  • Kochi University   理学部   生物

    1983.4 - 1987.3

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    Country: Japan

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  • Kochi University    

    - 1987

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Research History

  • Okayama University   Advanced Science Research Center   Professor

    2018.4

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  • Saga University   Instrumental Analysis Center   Associate Professor

    2010.5 - 2018.3

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  • Hiroshima University   Graduate School of Science

    1994.4 - 2010.4

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  • Hiroshima University   アイソトープ中央実験施設   Research Assistant

    1991.12 - 1994.3

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Professional Memberships

  • Atomic Energy Society of Japan

    2010.4

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  • The Society of Antibacterial and Antifungal Agents, Japan

    2009.4

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  • THE JAPAN RADIATION RESEARCH SOCIETY

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  • THE JAPANESE ENVIRONMENTAL MUTAGEN SOCIETY

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  • JAPAN HEALTH PHYSICS SOCIETY

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Committee Memberships

  • 日本原子力学会   中国・四国支部委員  

    2021.4   

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  • 日本アイソトープ協会中国・四国支部委員   中国・四国支部委員  

    2019.4   

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    Committee type:Academic society

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  • 日本アイソトープ協会   放射線安全取扱部会本部委員  

    2019.4 - 2024.3   

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  • 佐賀県   佐賀県立図書館協議会委員  

    2016.4 - 2018.3   

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    Committee type:Municipal

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  • 佐賀市   佐賀市空き家等審議会委員  

    2013.4 - 2016.3   

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    Committee type:Municipal

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Papers

  • Comparison of mutation spectra induced by gamma-rays and carbon ion beams Reviewed

    Yuka Tokuyama, Kanae Mori, Midori Isobe, Hiroaki Terato

    Journal of Radiation Research   65 ( 4 )   491 - 499   2024.6

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    The ionizing radiation with high linear energy transfer (LET), such as a heavy ion beam, induces more serious biological effects than low LET ones, such as gamma- and X-rays. This indicates a difference in the DNA damage produced by low and high LET radiations and their biological effects. We have been studying the differences in DNA damage produced by gamma-rays and carbon ion beams. Therefore, we analyze mutations induced by both ionizing radiations to discuss the differences in their biological effects in this study. pUC19 plasmid DNA was irradiated by carbon ion beams in the solution containing 1M dimethyl sulfoxide to mimic a cellular condition. The irradiated DNA was cloned in competent cells of Escherichia coli. The clones harboring some mutations in the region of lacZα were selected, and the sequence alterations were analyzed. A one-deletion mutation is significant in the carbon-irradiated DNA, and the C:G↔T:A transition is minor. On the other hand, the gamma-irradiated DNA shows mainly G:C↔T:A transversion. These results suggest that carbon ion beams produce complex DNA damage, and gamma-rays are prone to single oxidative base damage, such as 8-oxoguanine. Carbon ion beams can also introduce oxidative base damage, and the damage species is 5-hydroxycytosine. This was consistent with our previous results of DNA damage caused by heavy ion beams. We confirmed the causal DNA damage by mass spectrometry for these mutations.

    DOI: 10.1093/jrr/rrae050

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  • Shielding Ability of a Novel Iron Ceramic Material for Gamma-Rays Reviewed

    Midori ISOBE, Hiroyuki MORI, Narufumi OKADA, Yuriko MANNAMI, Hiroaki TERATO

    Radiation Safety Management   22   1 - 6   2023.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Radiation Safety Management  

    DOI: 10.12950/rsm.230809

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  • 同時使用の制限を行うグループ別管理の導入とその実践のための取り組み Reviewed

    今田結, 磯辺みどり, 永松知洋, 寺東宏明, 花房直志

    日本放射線安全管理学会誌   21 ( 2 )   64 - 68   2022.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

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  • キャビテーション高電圧パルス放電プラズマが示す放射線耐性細菌を含む水混入微生物に対する殺滅効果 Invited

    寺東宏明, 德山由佳, 西山博稀, 松永貴志, 吉田祐紀, 猪原哲

    日本防菌防黴学会誌   50 ( 8 )   347 - 348   2022.8

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

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  • Sterilizing Ability of High-Voltage Pulsed Discharge Plasma with Cavitation for Microorganisms Including Radio-Resistant Bacterium in Water Reviewed

    HIROAKI TERATO, YUKA TOKUYAMA, HIROKI NISHIYAMA, TAKASHI MATSUNAGA, YUKI YOSHIDA, SATOSHI IHARA

    Biocontrol Science   27 ( 1 )   41 - 46   2022

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Society for Antibacterial and Antifungal Agents, Japan  

    DOI: 10.4265/bio.27.41

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MISC

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Presentations

  • NORM放射線源の212Pb/212Biジェネレーターを用いた非密封放射性同位元素の安全取扱実習

    今田結, 磯辺みどり, 永松知洋, 寺東宏明, 花房直志

    第5回日本放射線安全管理学会・日本保健物理学会合同大会  2024.12.16 

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    Event date: 2024.12.16 - 2024.12.18

    Language:Japanese   Presentation type:Poster presentation  

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  • 炭素イオン線を照射したプラスミドDNA上に生じる変異

    寺東宏明, 德山由佳, 磯辺みどり, 森加奈恵

    日本環境変異原ゲノム学会第53回大会  2024.12.8 

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    Event date: 2024.12.7 - 2024.12.8

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ガンマ線と炭素イオン線による塩基損傷と変異について

    寺東宏明, 磯辺みどり, 森加奈恵, 德山由佳

    日本放射線影響学会第67回大会  2024.9.27 

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    Event date: 2024.9.25 - 2024.9.28

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ガンマ線と炭素イオン線によって生じる塩基損傷と変異スペクトルの比較

    寺東宏明, 磯辺みどり, 森加奈恵, 德山由佳

    第48回中国地区放射線影響研究会  2024.8.23 

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    Event date: 2024.8.23

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ホウ素化合物を投与したがん細胞内のホウ素の分布および化学状態の 放射光・光電子顕微鏡による解明

    脇田高徳, 井川和代, 池田直, 寺東宏明, 村岡祐治, 横谷尚睦

    日本物理学会 2024年春季大会  2024.3.19 

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    Event date: 2024.3.18 - 2024.3.21

    Language:Japanese  

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Works

  • 細胞内酸化的塩基損傷の検出系の確立

    2001

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  • 酸化プリン損傷修復酵素OGG1の酵素特性の研究

    2000

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  • Characterization of oxoguanine DNA glycosylase, OGG1

    2000

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  • 脱塩基損傷高感度検出系の開発

    1998

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  • 酸化的ピリミジン損傷の哺乳類修復酵素の研究

    1998

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Awards

  • 寺島論文賞

    2010.11   日本放射線影響学会  

    寺東 宏明

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Research Projects

  • Involvement of DNA damage and mutation in heavy particle, BNCT, and alpha internal radiation therapy

    Grant number:22K12372  2022.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    寺東 宏明

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • Development of practical water purification system using water cavitation and plasma

    Grant number:20K04446  2020.04 - 2023.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    猪原 哲, 寺東 宏明

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    循環型社会と安全安心が担保された社会を世界的な視点で実現するためには,水質浄化を含めた水処理は必須の課題であるものの,高度化・多様化した現在は,既存の水処理技術では限界がある。本研究は,水中プラズマを使った水処理装置の実用化を目指したものである。独自のプラズマ発生方式である「水中キャビテーション放電」を採用し,実用化のために必要な知見を明らかにすることを目的とした。当初の2020年度の実施計画は,プラズマリアクタの設計・試作を行い,プラズマ発生テストおよび殺菌効果の実証することであった。
    今年度の初期の研究において、実際の現地の被処理水の導電率(約50mS/m、国内の約5倍)を想定した電極設計とリアクタ設計が必要になることが分かった。これを受けて、イオン交換樹脂カートリッジを水処理装置に組み込み、プラズマ発生を促進する方法を検討したが、必要流量と水圧との関係からさらに検討が必要であることが分かった。高導電率中でも十分なプラズ発生が得られるためには、電極部でのキャビテーション気泡量を増加させる必要がある。3Dプリンターを用いて各種条件のリアクタを製作し、電極設置条件に対する気泡発生量の最適条件を実験的に調べた。

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  • Development of dormancy breaking technology for temperate fruit tree with pulsed high voltage application

    Grant number:17K06305  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ihara Satoshi

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    The rise in temperature due to climate change has an effect on agricultural products, especially on temperate fruit trees. Temperate fruit trees dormant during the growth cycle, but dormancy awakening is significantly affected by temperature rise. If dormancy and awakening are not sufficient, the yield will be reduced due to flowering and poor fruiting. Cyanamide is used as a dormant breaker, but its effect is not sufficient. This study is a basic study for the development of a technique for breaking dormancy of temperate fruit trees. Peach was selected as an experimental sample, and changes in germination rate by applying pulse power and quantitative analysis of plant hormones were performed. As a result, it was found that the abscisic acid concentration was changed by the application of pulse power, and it was clarified that the application of pulse power contributed to the physiological action in dormancy and arousal.

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  • Fundamental research on high speed water treatment for large volume water using water cavitation and plasma

    Grant number:26420238  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ihara Satoshi

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    Purpose of this research is to build technology on purification of water with large volume using one-path treatment. Especially water cavitation and discharge plasma were used simultaneously for purification in this research.
    Escherichia coli whose initial number density was 2×1015 m-3 was used as a specimen for testing. In our experiments, 5 pair of electrodes was used, and a sterilization ratio of about 83 %, 97 % were obtained at a treatment time of 6, 18 seconds, respectively. A treatment time of 6 seconds corresponds to one-path treatment. From the results, it seems that more than 90 % of sterilization ratio is obtained at 15 pair of electrodes.

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  • Elucidation of radiation biological effect with quantitative and qualitative analyses of base damage cluster

    Grant number:25340034  2013.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Terato Hiroaki, KONDO Toshihiro, TOKUYAMA Yuka

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

    Clustered DNA damage is a specific type of DNA damage with ionizing radiation. In this study, we analyzed the yield of clustered base damage in cultured cells irradiated with various heavy ion beams, and investigated the repair process in post-irradiation cultured cells. Chinese hamster ovary (CHO) cells were irradiated by carbon, silicon, argon and iron ion beams with LETs of 13, 55, 90 and 200 keV/μm, respectively. The cell electrophoresis indicated that clustered base damage yields decreased as the LET increased. Then, clustered DNA damage repair was investigated using DNA repair mutant cells. DNA double-strand breaks accumulated in the mutant cells lacking Xrcc1 after irradiation, and the cell viability decreased. On the other hand, mouse embryonic fibroblast (Mef) cells lacking both Nth1 and Ogg1 became more resistant than the wild type. Thus, clustered base damage seems to be involved in the expression of heavy ion beam biological effects via the repair process.

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Class subject in charge

  • Basic Radiation Medicine (2024academic year) special  - その他

  • Introduction of Safety and Health (2024academic year) Fourth semester  - 金5~6

  • Basic Radiation Medicine (2023academic year) special  - その他

  • Introduction of Safety and Health (2023academic year) Fourth semester  - 金5~6

  • Basic Radiation Medicine (2022academic year) special  - その他

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