Faculty Profiles - YORIFUJI Takashi

Papers - YORIFUJI Takashi

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Non-woven Masks and SARS-CoV-2 Infection in a Cluster Setting in Japan Reviewed

Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji

Japanese Journal of Infectious Diseases 78 ( 2 ) 110 - 113 2025.3

Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries Reviewed

Tetsuya Yumoto, Takafumi Obara, Takashi Hongo, Atsuyoshi Iida, Kohei Tsukahara, Morihiro Katsura, Yutaka Kondo, Hideto Yasuda, Shigeki Kushimoto, Takashi Yorifuji, Hiromichi Naito, Atsunori Nakao, Tetsuya Yumoto, Atsuyoshi Iida, Morihiro Katsura, Yutaka Kondo, Hideto Yasuda, Shigeki Kushimoto, Hiromichi Naito, Tomoya Ito, Motoyoshi Yamamoto, Yoshihiro Yamamoto, Hiroto Manase, Nozomi Takahashi, Akinori Osuka, Suguru Annen, Nobuki Ishikawa, Kazushi Takayama, Keita Minowa, Kenichi Hakamada, Akari Kusaka, Mineji Hayakawa, Shota Kawahara, Satoshi Hirano, Marika Matsumoto, Kohei Kusumoto, Hiroshi Kodaira, Chika Kunishige, Keiichiro Toma, Yusuke Seino, Michio Kobayashi, Masaaki Sakuraya, Takafumi Shinjo, Shigeru Ono, Haruka Taira, Kazuhiko Omori, Yoshio Kamimura, Atsushi Shiraishi, Rei Tanaka, Yukihiro Tsuzuki, Yukio Sato, Noriaki Kyogoku, Masafumi Onishi, Kaichi Kawai, Kazuyuki Hayashida, Keiko Terazumi, Akira Kuriyama, Susumu Matsushime, Osamu Takasu, Toshio Morita, Nagato Sato, Wataru Ishii, Michitaro Miyaguni, Shingo Fukuma, Yosuke Nakabayashi, Yoshimi Ohtaki, Kiyoshi Murata, Masayuki Yagi, Tadashi Kaneko, Shigeru Takamizawa, Akihiro Yasui, Yasuaki Mayama, Masafumi Gima, Ichiro Okada, Asuka Tsuchiya, Koji Ishigami, Yukiko Masuda, Yasuo Yamada, Hiroshi Yasumatsu, Kenta Shigeta, Kohei Kato, Fumihito Ito, Yoshitaka Saegusa, Tomohiko Azuma, Shima Asano, Takehiro Umemura, Norihiro Goto, Takao Yamamoto, Junichi Ishikawa, Elena Yukie Uebayashi, Shunichiro Nakao, Yuko Ogawa, Takashi Irinoda, Yuki Narumi, Miho Asahi, Takayuki Ogura, Takashi Hazama, Shokei Matsumoto, Daisuke Miyamoto, Keisuke Harada, Narumi Kubota, Yusuke Konda, Takeshi Asai, Tomohiro Muronoi, Kazuhide Matsushima, Toru Hifumi, Kasumi Shirasaki, Shigeyuki Furuta, Atsuko Fujikawa, Makoto Takaoka, Kaori Ito, Satoshi Nara, Atsushi Tanikawa, Masato Tsuchikane, Naoya Miura, Naoki Sakoda, Tadaaki Takada, Shogo Shirane, Akira Endo, Keita Nakatsutsumi, Kenta Sugiura, Yusuke Hagiwara, Tamotsu Gotou

Scientific Reports 15 ( 1 ) 8502 - 8502 2025.3

Impact of coronavirus disease 2019 emergency declarations on surgeries for deep neck infection incidence in Japan Reviewed

Kensuke Uraguchi, Naomi Matsumoto, Shohei Fujimoto, Takashi Yorifuji, Mizuo Ando

Journal of Infection and Chemotherapy 31 ( 3 ) 102601 - 102601 2025.3

Efficacy of telerehabilitation for patients after hip fracture surgery: A systematic review and meta-analysis Reviewed

Takahiro Tsuge, Norio Yamamoto, Shunsuke Taito, Takanori Miura, Daijo Shiratsuchi, Takashi Yorifuji

Journal of Telemedicine and Telecare 31 ( 2 ) 174 - 183 2025.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Introduction

This study aimed to determine the efficacy of telerehabilitation for patients after hip fracture surgery through a systematic review and meta-analysis.

Methods

Eight electronic databases were searched in August 2022. The primary outcomes were mobility outcomes, activities of daily living (ADL) outcomes, and all adverse events, whereas the secondary outcomes were pain, health-related quality of life, and fall efficacy scale score.

Results

Seven randomized controlled trials were eligible for this study. The evidence regarding the effect of telerehabilitation on mobility outcomes (standardized mean difference (SMD): 0.05, 95% confidence interval (CI): −0.39 to 0.48) and all adverse events (risk ratio: 1.14, 95% CI: 0.62 to 2.21) was very uncertain. A clinically irrelevant but significant mean difference (MD) in ADL outcomes was found (MD: 4.82, 95% CI: 2.63 to 7.01). Telerehabilitation may result in a slight increase in fall efficacy scale score (SMD: 0.26, 95% CI: −0.02 to 0.54) and little to no difference in pain (MD: −1.0, 95% CI: −18.31 to 16.31).

Conclusions

The efficacy of telerehabilitation for patients after hip fracture surgery was uncertain with respect to the mobility outcomes, all adverse events, and pain, with no clinically meaningful differences in ADL outcomes. Telerehabilitation may be necessary to be considered for patients after hip fracture surgery to improve their confidence in their ability to perform daily activities without falling. Therefore, medical staff may consider telerehabilitation for hip fractures.

DOI： 10.1177/1357633x231181632

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Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/1357633X231181632

Outdoor playing during preschool was associated with a reduced risk of school‐age obesity in Japan Reviewed

Takahiro Tsuge, Naomi Matsumoto, Soshi Takao, Takashi Yorifuji

Acta Paediatrica 114 ( 2 ) 303 - 309 2025.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Aim

This study investigated the association between outdoor play habits during preschool and school‐age obesity.

Methods

We conducted a longitudinal cohort study of all children born in Japan during 2 weeks in January and July 2001. We defined outdoor play habits at age 2.5 years (third survey) as exposure, while parent‐reported height and weight at age 7 years (seventh survey) were defined as overweight and obesity status using the WHO reference. Logistic regression models were used to estimate odds ratios (ORs) for associations between preschool outdoor play habits and school‐age obesity, adjusting for parental and child factors.

Results

Of 53 575 children born, 42 812 had data on outdoor play habits at age 2.5 years, with 91% (38 970) having such habits. At age 7 years, 31 743/42 812 (74%) children had height and weight data, with 3249/31 743 (10%) classified as overweight or obesity (BMI SD score ≥1.0). Outdoor play habits were negatively associated with obesity (adjusted OR 0.85, 95% confidence interval (CI): 0.74–0.97).

Conclusion

Outdoor play habits in early preschool years are associated with a reduced risk of school‐age obesity. Parents and caregivers may consider encouraging their children to outdoor play habits at an early age to help prevent obesity later in life.

DOI： 10.1111/apa.17441

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Association Between Dinner-to-Bed Time and Gastroesophageal Reflux-Related Diseases in Children Reviewed

Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

Cureus 17 ( 1 ) e77709 - e77709 2025.1

Cesarean delivery on child health and development in Japanese nationwide birth cohort Reviewed

Naomi Matsumoto, Takashi Mitsui, Kei Tamai, Tomoya Hirota, Hisashi Masuyama, Takashi Yorifuji

Scientific Reports 15 ( 1 ) 2485 - 2485 2025.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997–1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups.

DOI： 10.1038/s41598-025-87043-2

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Other Link： https://www.nature.com/articles/s41598-025-87043-2

Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan. Reviewed

Shigehara K., Matsumoto N., Tsuge M., Uda K., Saito Y., Yashiro M., Yorifuji T., Ikeda M., Tsukahara H.

Allergy Asthma Clin Immunol. 21 ( 1 ) 4 - 4 2025.1

Impact of high blood pressure on the risk of mortality among Japanese people aged 65 years and older Reviewed

Akagi S., Takao S., Matsuo R., Matsumoto N., Yorifuji T.

Geriatr Gerontol Int. 25 ( 1 ) 82 - 89 2025.1

ABCC8 haploinsufficiency in a mother-daughter pair with young-onset diabetes with and without neonatal hypoglycemia. Reviewed

Uehara E., Shimura N., Matsubara K., Kageyama I., Yorifuji T., Fukami M.

Clin Pediatr Endocrinol. 34 ( 1 ) 66 - 69 2025.1

In Vitro Fertilization and Long-Term Child Health and Development: Nationwide birth cohort study in Japan Reviewed

Matsumoto N., Mitsui T., Kadowaki T., Mitsuhashi T., Hirota T., Masuyama H., Yorifuji T.

Eur J Pediatr. 184 ( 1 ) 24 - 24 2024.11

A nationwide longitudinal survey of infantile injury and its recurrence in Japan. Reviewed

Hiraoka T., Obara T., Matsumoto N., Tsukahara K., Hongo T., Nojima T., Hisamura M., Yumoto T., Nakao A., Yorifuji T., Naito H.

Sci Rep. 14 ( 1 ) 24716 - 24716 2024.10

Respiratory Severity Score and Neurodevelopmental Outcomes at Age 3 Years in Extremely Preterm Infants Reviewed

Tamai K, Takeuchi A, Nakamura M, Matsumoto N, Yorifuji T, Kageyama M

American Journal of Perinatology 41 ( 13 ) 1841 - 1847 2024.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Georg Thieme Verlag KG

Objective We aimed to examine the association between respiratory severity score (RSS; mean airway pressure × fraction of inspired oxygen) and neurodevelopmental outcomes in extremely preterm infants.

Study Design This was a single-center, retrospective cohort study. We analyzed data from extremely preterm infants who were admitted to the neonatal intensive care unit at Okayama Medical Center between 2010 and 2019. Infants without invasive respiratory management during the first day of life were excluded. The exposure variable was the highest RSS during the first day of life. RSS was categorized into two groups: low (<3.5) and high (≥3.5) RSS. The primary outcome was death or neurodevelopmental impairment at age 3 years, defined as cognitive impairment (developmental quotient <70) or the presence of cerebral palsy. Secondary outcomes were the components of the primary outcome. We conducted robust Poisson regression analyses to investigate the association between RSS category and primary and secondary outcomes, adjusting for perinatal confounders.

Results The cohort included 97 infants with neurodevelopmental data, of whom 34 and 63 infants were in the low- and high-RSS categories, respectively. The median (interquartile range) gestational age and birth weight were 26.0 (24.7–26.9) and 25.7 (24.6–26.7) weeks and 761 (584–866) and 806 (618–898) g for infants in the low- and high-RSS categories, respectively. Compared with infants in the low-RSS category, those in the high-RSS category had a greater risk of death or neurodevelopmental impairment at age 3 years (26.3 vs. 42.3%; adjusted risk ratio [RR], 2.0; 95% confidence interval [CI], 1.1–3.5) and neurodevelopmental impairment at age 3 years (17.6 vs. 28.6%; adjusted RR, 2.7; 95% CI, 1.3–5.9).

Conclusion High RSS (≥3.5) during the first day of life was associated with an increased risk of neurodevelopmental impairment at age 3 years in extremely preterm infants.

Key Points

DOI： 10.1055/a-2267-4719

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Prognostic performance of gray-white matter ratio in adult out-of-hospital cardiac arrest patients after receiving extracorporeal cardiopulmonary resuscitation Reviewed

Hongo T, Naito H, Nasu M, Yumoto T, Kosaki Y, Yorifuji T, Hifumi T, Inoue A, Sakamoto T, Kuroda Y, Nakao A, SAVE-J II Study Group

Resuscitation 203 110351 - 110351 2024.10

Neurectomy for allergic rhinitis in Japan: Increasing trends and surgeon preferences Reviewed

Makihara S, Hosoya K, Uraguchi K, Maeda Y, Komachi T, Yorifuji T, Ando M, Matsune S, Okubo K

Auris Nasus Larynx 51 ( 5 ) 834 - 839 2024.10

Zinc deficiency is a potential risk factor for COVID-19 progression to pneumonia requiring oxygen therapy Reviewed

Fujita K, Ocho K, Kadowaki T, Yorifuji T, Hagiya H, Otsuka F

Journal of Infection and Chemotherapy 30 ( 10 ) 978 - 982 2024.10

Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan Reviewed

Takanaga S., Matsumoto N., Kadowaki T., Takao S., Yorifuji T.

Acta Med Okayama. 78 ( 5 ) 363 - 370 2024.10

Postnatal weight loss and neurodevelopmental outcomes at age 3 years in extremely preterm infants: a cohort study. Reviewed

Tamai K., Matsumoto N., Yorifuji T., Takeuchi A., Nakamura M., Kageyama M.

BMC Pediatr. 24 ( 1 ) 618 - 618 2024.9

Antibody Titers and the Risk of Infection During the SARS-CoV-2 Omicron Phase in Bizen City, Japan Reviewed

Kadowaki T, Sasaki A, Matsumoto N, Mitsuhashi T, Hagiya H, Takao S, Yorifuji T

The Journal of Infectious Diseases 230 ( 3 ) 662 - 669 2024.9

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Understanding the association between the immune response and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has implications for forthcoming prevention strategies. We evaluated the association between antibody titers and the risk of infection for the general population during the Omicron-dominant phase.

Methods

This was a prospective cohort study of residents or people affiliated with institutions in Bizen City, which included 1899 participants. We measured the titers of antibodies against SARS-CoV-2 repeatedly every 2 months from June 2022 to March 2023. Infection status was obtained from self-reported questionnaires and the official registry. We estimated risk ratios (RRs) for infection within 2 months of the date of each antibody measurement with 95% confidence intervals (CIs) based on antibody titer categories and spline functions.

Results

Compared with the &lt;2500 arbitrary unit (AU)/mL category, the 2500–5000, 5000–10 000, and ≥10 000 AU/mL categories had adjusted RRs of 0.81 (95% CI, .61–1.08), 0.51 (95% CI, .36–.72), and 0.41 (95% CI, .31–.54), respectively. The spline function showed a nonlinear relationship between antibody titer and risk.

Conclusions

Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future prevention strategies.

DOI： 10.1093/infdis/jiae207

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Efficacy of Protein and Essential Amino Acid Supplementation in Lower Limb Surgeries: A Systematic Review and Meta-Analysis. Reviewed

Hagiyama A., Yamamoto N., Watanabe J., Tsuge T., Nakashima Y., Nakao S., Sato H., Yorifuji T.

Cureus. 16 ( 9 ) e69212 - e69212 2024.9

Shifting paradigms in endoscopic sinus surgery: a comprehensive analysis from Japan’s national database Reviewed

Makihara S, Uraguchi K, Fujimoto S, Shimizu A, Kariya S, Okano M, Yorifuji T, Ando M

Acta Oto-Laryngologica 144 ( 9 ) 503 - 508 2024.9

Survey of pharyngeal foreign bodies in Japan: An ecological study using the nationwide claims data Reviewed

Tanaka S, Uraguchi K, Suzuki E, Matsumoto N, Tsumura M, Fujimoto S, Miyamoto S, Yorifuji T, Ando M

International Journal of Pediatric Otorhinolaryngology 184 112055 - 112055 2024.9

Kinetics of SARS-CoV-2 antibody titers after booster vaccinations during an Omicron surge in Japan Reviewed

Matsumoto N, Sasaki A, Kadowaki T, Mitsuhashi T, Takao S, Yorifuji T

Vaccine 42 ( 21 ) 126156 - 126156 2024.8

Antibody levels and the risk of SARS-CoV-2 infection during the Omicron surge Reviewed

Sasaki A, Kadowaki T, Matsumoto N, Mitsuhashi T, Takao S, Yorifuji T

GHM Open 4 ( 1 ) 52 - 53 2024.7

Pediatric otitis media in Japan: A nationwide longitudinal study of the pre- and post-pneumococcal conjugate vaccine eras born in 2001 and 2010 Reviewed

Uraguchi K, Matsumoto N, Mitsuhashi T, Takao S, Makihara S, Ando M, Yorifuji T

Vaccine 42 ( 19 ) 4081 - 4087 2024.7

Association Between Clinical Remission of Infantile-Onset Allergic Rhinitis During the School-Age Period and the Type of Housing: A Longitudinal Population-Based Japanese Study Reviewed

Uraguchi K, Matsumoto N, Mitsuhashi T, Takao S, Makihara S, Ando M, Yorifuji T

Journal of Pediatric Health Care 38 ( 4 ) 629 - 636 2024.7

Longitudinal changes in antibody titers in a nursing home in which COVID-19 clusters occurred Reviewed

Kadowaki T, Sasaki A, Matsumoto N, Mitsuhashi T, Takao S, Yorifuji T

American Journal of Infection Control 52 ( 7 ) 765 - 769 2024.7

Emergency Dispatches for Suicide Attempts during the COVID-19 Pandemic in Okayama, Japan: An Interrupted Time-series Analysis Reviewed

Yamamura Y, Matsumoto N, Takao S, Yorifuji T

JMA Journal 7 ( 3 ) 418 - 422 2024.7

Impact of sex of bystanders who perform cardiopulmonary resuscitation on return of spontaneous circulation in out-of-hospital cardiac arrest patients: A retrospective, observational study Reviewed

Nakamura S, Nojima T, Obara T, Hongo T, Yumoto T, Yorifuji T, Nakao A, Naito H

Resuscitation Plus 18 100659 - 100659 2024.6

Association between mean airway pressure during high-frequency oscillatory ventilation and pulmonary air leak in extremely preterm infants during the first week of life Reviewed

Tamai K, Takeuchi A, Nakamura M, Nakamura K, Matsumoto N, Yorifuji T, Kageyama M

Frontiers in Pediatrics 12 1410627 - 1410627 2024.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

Background

While positive pressure ventilation has been considered an important contributing factor associated with pulmonary air leaks, studies examining the association between specific ventilatory settings during acute-phase high-frequency oscillatory ventilation (HFOV) and pulmonary air leaks among extremely preterm infants are limited.

Methods

This was a single-center retrospective cohort study conducted at an institution that primarily used HFOV after intubation in extremely preterm infants. We analyzed data from extremely preterm infants born between 2010 and 2021. The primary outcome was pulmonary air leakage during the first 7 days of life. The exposure variable was the maximum mean airway pressure (MAP) on HFOV during the first 7 days of life or before the onset of pulmonary air leaks. Maximum MAP was categorized into three groups: low (7–10 cmH₂O), moderate (11–12 cmH₂O), and high (13–15 cmH₂O) MAP categories. We conducted robust Poisson regression analyses after adjustment for perinatal confounders, using the low MAP category as the reference.

Results

The cohort included 171 infants (low MAP, 123; moderate MAP, 27; and high MAP, 21). The median (interquartile range) gestational age and birth weight were 25.7 (24.3–26.7), 25.7 (24.9–26.9), and 25.3 (24.3–26.6) weeks and 760 (612–878), 756 (648–962), and 734 (578–922) g for infants in the low, moderate, and high MAP categories, respectively. Compared to infants in the low MAP category, those in the high MAP category had a higher incidence of pulmonary air leaks (4.1% vs. 33.3%; adjusted risk ratio, 5.4; 95% confidence interval, 1.6–18.5). In contrast, there was no clear difference in the risk of pulmonary air leaks between the moderate and low MAP categories (3.7% vs. 4.1%; adjusted risk ratio, 0.9; 95% confidence interval, 0.1–6.1).

Conclusion

Extremely preterm infants requiring high MAP (≥13 cmH₂O) in acute-phase HFOV had a higher risk of pulmonary air leak during the first 7 days of life.

DOI： 10.3389/fped.2024.1410627

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Long-term, patient-centered, frailty-based outcomes of older critical illness survivors from the emergency department: a post hoc analysis of the LIFE Study Reviewed

Hongo T, Yumoto T, Inaba M, Taito S, Yorifuji T, Nakao A, Naito H, LIFE Study Investigators.

BMC Geriatrics 24 ( 1 ) 257 - 257 2024.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Evidence indicates frailty before intensive care unit (ICU) admission leads to poor outcomes. However, it is unclear whether quality of life (QOL) and activities of daily living (ADL) for survivors of critical illness admitted to the ICU via the emergency department remain consistent or deteriorate in the long-term compared to baseline. This study aimed to evaluate long-term QOL/ADL outcomes in these patients, categorized by the presence or absence of frailty according to Clinical Frailty Scale (CFS) score, as well as explore factors that influence these outcomes.

Methods

This was a post-hoc analysis of a prospective, multicenter, observational study conducted across Japan. It included survivors aged 65 years or older who were admitted to the ICU through the emergency department. Based on CFS scores, participants were categorized into either the not frail group or the frail group, using a threshold CFS score of < 4. Our primary outcome was patient-centered outcomes (QOL/ADL) measured by the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) and the Barthel Index six months post-ICU admission, comparing results from baseline. Secondary outcomes included exploration of factors associated with QOL/ADL six months post-ICU admission using multiple linear regression analyses.

Results

Of 514 candidates, 390 participants responded to the EQ-5D-5L questionnaire, while 237 responded to the Barthel Index. At six months post-admission, mean EQ-5D-5L values declined in both the not frail and frail groups (0.80 to 0.73, p = 0.003 and 0.58 to 0.50, p = 0.002, respectively); Barthel Index scores also declined in both groups (98 to 83, p < 0.001 and 79 to 61, p < 0.001, respectively). Multiple linear regression analysis revealed that baseline frailty (β coefficient, -0.15; 95% CI, − 0.23 to − 0.07; p < 0.001) and pre-admission EQ-5D-5L scores (β coefficient, 0.14; 95% CI, 0.02 to 0.26; p = 0.016) affected EQ-5D-5L scores at six months. Similarly, baseline frailty (β coefficient, -12.3; 95% CI, − 23.9 to − 0.80; p = 0.036) and Barthel Index scores (β coefficient, 0.54; 95% CI, 0.30 to 0.79; p < 0.001) influenced the Barthel Index score at six months.

Conclusions

Regardless of frailty, older ICU survivors from the emergency department were more likely to experience reduced QOL and ADL six months after ICU admission compared to baseline.

DOI： 10.1186/s12877-024-04881-x

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Other Link： https://link.springer.com/article/10.1186/s12877-024-04881-x/fulltext.html

Staged repair for complete atrioventricular septal defect in patients weighing less than 4.0 kg. Reviewed

Kobayashi Y, Kasahara S, Sano S, Suzuki H, Suzuki E, Yorifuji T, Kotani Y

J Thorac Cardiovasc Surg. 167 ( 3 ) 1136 - 1144 2024.3

A nationwide birth cohort in Japan showed increased risk of early childhood hospitalisation in infants born small for gestational age Reviewed

Ohyama A, Matsumoto N, Tamai K, Washio Y, Yoshimoto J, Yorifuji T, Tsukahara H

Acta Paediatrica 113 ( 3 ) 480 - 485 2024.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Aim

To examine associations between children being born small for gestational age and childhood hospitalisation following term and preterm births.

Methods

This study included 34 564 children from a nationwide population‐based longitudinal survey starting in 2010, comprising 32 603 term births and 1961 preterm births. Children's hospitalisation history was examined during two observational periods, 6–18 and 6–66 months of age. Logistic regression analysis was conducted, adjusting for child and parental confounders, with children born appropriate for gestational age as reference.

Results

Children born small for gestational age were more likely to be hospitalised during early childhood than those born appropriate for gestational age. The odds ratio (95% confidence interval) for hospitalisation from 6 to 66 months of age was 1.19 (1.05–1.34) in term children born small for gestational age and 1.47 (1.05–2.06) for preterm children born small for gestational age, compared with those born appropriate for gestational age. The risk of hospitalisation from 6 to 66 months of age in children born small for gestational age was observed for bronchitis/pneumonia.

Conclusion

We observed the adverse effects of small for gestational age on hospitalisation during early childhood in both term and preterm births, particularly for bronchitis and pneumonia.

DOI： 10.1111/apa.17032

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Longitudinal antibody dynamics after COVID-19 vaccine boosters based on prior infection status and booster doses Reviewed

Matsumoto N, Sasaki A, Kadowaki T, Mitsuhashi T, Takao S, Yorifuji T

Scientific Reports 14 ( 1 ) 4564 - 4564 2024.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Global concern over COVID-19 vaccine distribution disparities highlights the need for strategic booster shots. We explored longitudinal antibody responses post-booster during the Omicron wave in a Japanese cohort, emphasizing prior infection and booster doses. This prospective cohort study included 1763 participants aged 18 years and older with at least three vaccine doses (7376 datapoints). Antibody levels were measured every 2 months. We modeled temporal declines in antibody levels after COVID-19 vaccine boosters according to prior infection status and booster doses using a Bayesian linear mixed-effects interval-censored model, considering age, sex, underlying conditions, and lifestyle. Prior infection enhanced post-booster immunity (posterior median 0.346, 95% credible interval [CrI] 0.335–0.355), maintaining antibody levels (posterior median 0.021; 95% CrI 0.019–0.023) over 1 year, in contrast to uninfected individuals whose levels had waned by 8 months post-vaccination. Each additional booster was correlated with higher baseline antibody levels and slower declines, comparing after the third dose. Female sex, older age, immunosuppressive status, and smoking history were associated with lower baseline post-vaccination antibodies, but not associated with decline rates except for older age in the main model. Prior infection status and tailored, efficient, personalized booster strategies are crucial, considering sex, age, health conditions, and lifestyle.

DOI： 10.1038/s41598-024-55245-9

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Other Link： https://www.nature.com/articles/s41598-024-55245-9

Treatment interruption in hypertensive patients during the COVID‐19 pandemic: An interrupted time series analysis using prescription data in Okayama, Japan Reviewed

Nakamura N, Mitsuhashi T, Matsumoto N, Hayase S, Yorifuji T

Journal of General and Family Medicine 25 ( 2 ) 102 - 109 2024.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Background

The COVID‐19 pandemic has impacted healthcare behaviors, leading to fewer pediatric visits in Japan and potentially fewer visits by adult patients. However, existing Japanese studies on treatment interruptions have generally relied on questionnaire‐based methods. In this study, we assessed the impact of the pandemic on antihypertensive treatment interruption using real‐world prescription data.

Methods

We conducted an interrupted time series analysis using the National Health Insurance Database in Okayama Prefecture, Japan. Participants included individuals aged 40–69 years with at least one antihypertensive prescription between 2018 and 2020. Treatment interruption was defined as a 3‐month or longer gap in prescriptions after medication depletion. We used segmented Poisson regression with models unadjusted and adjusted for seasonality and over‐dispersion to assess monthly treatment interruptions before and after Japan's April 2020 emergency.

Results

During the study period, 23.0% of 55,431 participants experienced treatment interruptions. Cyclical fluctuations in interruptions were observed. The crude analysis indicated a 1.2‐fold increase in treatment interruptions following the pandemic; however, the adjusted models showed no significant changes. Even among higher‐risk groups, such as women, younger adults, and those with shorter prescriptions, no significant alterations were observed.

Conclusion

We found no significant impact of the COVID‐19 pandemic on antihypertensive treatment interruption in Okayama Prefecture. The less severe outbreak in the area or increased use of telemedicine and extended prescriptions may have contributed to treatment continuity. Further research is needed using a more stable and comprehensive database, broader regional data, and detailed prescription records to validate and extend our findings.

DOI： 10.1002/jgf2.678

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COVID-19 pandemic and language development in children at 18 months: a repeated cross-sectional study over a 6-year period in Japan Reviewed

Matsuo R, Matsumoto N, Mitsuhashi T, Yorifuji T

Archives of Disease in Childhood 109 ( 2 ) 158 - 164 2024.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：BMJ

Objective

To evaluate the impact of the COVID-19 pandemic experience on language development among children, we compared language development at 18 months of age, before and during the pandemic in Japan, where strict control measures continued over a long period.

Methods

This was a repeated cross-sectional study and we included children who attended the 18-month health check-up provided by the Okayama City Public Health Center between January 2017 and December 2022 (n=33 484). We compared indicators of language development before (from January 2017 to February 2020) and during (from March 2020 to December 2022) the pandemic. Our primary outcome was the proportion of children who required follow-up for language development by the Public Health Center. The secondary outcome was the proportion of children who could not say three or more meaningful words. We estimated risk ratios (RRs) and their 95% CIs, adjusted for potential confounders.

Results

The prevalence of the primary outcome was 33.5% before the pandemic and 36% during the pandemic. Compared with before the pandemic, increased RRs for the primary and secondary outcomes were observed during the pandemic, with RRs (95% CIs) of 1.09 (1.06–1.13) for the primary outcome and 1.11 (1.05–1.17) for the secondary outcome. Although the statistical interactions were not significant, the RRs were higher for children cared for at home than those in nursery schools and with ≤3 family members than those with ≥4 family members.

Conclusions

The COVID-19 pandemic was associated with an increased risk of impaired language development in children at 18 months. More extensive support is needed for higher risk families, as well as follow-up of long-term language development in children affected by the COVID-19 pandemic.

DOI： 10.1136/archdischild-2023-325926

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Delivery room intubation and neurodevelopment among extremely preterm infants Reviewed

Tamai K, Matsumoto N, Yorifuji T, Takeuchi A, Nakamura M, Nakamura K, Kageyama M, Neonatal Research Network of Japan

Pediatric Research 95 ( 7 ) 1897 - 1902 2024.1

Correction: longitudinal impact of the COVID-19 pandemic on the development of mental disorders in preadolescents and adolescents Reviewed

Matsumoto N, Kadowaki T, Takanaga S, Shigeyasu Y, Okada A, Yorifuji T

BMC Public Health 24 ( 1 ) 45 - 45 2024.1

Complementary and Alternative Medicine Use, Cancer Screening, and Medical Checkups in Japan from 2001 to 2013: A Repeated Cross-Sectional Study. Reviewed

Matsuki N, Suzuki E, Mitsuhashi T, Subramanian SV, Takao S, Yorifuji T

J Integr Complement Med. 30 ( 1 ) 47 - 56 2024.1

An Internet-based survey of hepatitis B vaccination status among acupuncturists in Japan. Reviewed

Matsuki N., Suzuki E., Tsuda T., Doi H., Yorifuji T.

Japanese Acupuncture and Moxibustion 18 8 - 14 2024

Characteristics of Abnormalities in Somatosensory Submodalities Observed in Residents Exposed to Methylmercury Reviewed

Takaoka S, Fujino T, Shigeoka SI, Yorifuji T

Toxics 11 ( 12 ) 1023 - 1023 2023.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Hundreds of thousands of people living along the Yatsushiro Sea coast have been exposed to methylmercury from the contaminated water of the Chisso factory in Minamata. The most common neurological disorder caused by methylmercury is somatosensory disturbance, but very few studies have been conducted in the world to determine its pathophysiology and origin, including the Japanese cases, which have produced numerous intoxicated individuals. We have already shown in previous studies the body part where the disorder occurs and that its cause is not peripheral nerve damage but damage to the parietal lobes of the cerebrum. We reanalyzed the results of subjective symptoms, neurological findings, and quantitative sensory measurements in 197 residents (63.2 ± 10.7 years old) from contaminated areas exposed to methylmercury from seafood and 130 residents (63.7 ± 9.3 years old) from control areas, the same subjects as in previous studies, to determine the characteristics of somatosensory disturbance in detail. The most commonly affected sensory modalities were superficial peripheral touch and pain in the extremities, followed by two-point discrimination and deep senses, and in the most severe cases, full-body sensory dysfunction and impairment of all sensory submodalities. The severity of sensory submodalities correlated with each other but not with peripheral nerve conduction test indices, further confirming the correctness of our assertion about the responsible foci of sensory disturbance. The health effects of chronic methylmercury toxicosis can be elucidated by a detailed examination of sensory deficits.

DOI： 10.3390/toxics11121023

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Effect of stomach inflation during cardiopulmonary resuscitation on return of spontaneous circulation in out-of-hospital cardiac arrest patients: A retrospective observational study. Reviewed

Naito H, Hanafusa H, Hongo T, Yumoto T, Yorifuji T, Weissman A, Rittenberger JC, Guyette FX, Fujishima M, Maeyama H, Nakao A

Resuscitation. 109994 2023.12

Obesity, overweight, and severe prognosis in COVID-19 patients in Japan. Reviewed

Kadowaki T, Matsumoto N, Matsuo R, Mitsuhashi T, Sasaki A, Takao S, Yorifuji T

J Infect Chemother. 29 ( 12 ) 1109 - 1113 2023.12

Fine Particulate Matter and Diabetes Prevalence in Okayama, Japan. Reviewed

Tani Y, Kashima S, Mitsuhashi T, Suzuki E, Takao S, Yorifuji T

Acta Med Okayama. 77 ( 6 ) 607 - 612 2023.12

Review of a Series of Surveys on Adverse Reactions to the COVID-19 mRNA-1273 Vaccine at Okayama University. Reviewed

Matsumoto N, Higuchi C, Miyaji C, Mitsuhashi T, Hagiya H, Takao S, Yorifuji T

Acta medica Okayama 77 ( 6 ) 567 - 575 2023.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.

DOI： 10.18926/AMO/66148

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Epidemiology and Reporting Characteristics of Systematic Reviews in Orthopedic Journals: A Meta-Epidemiological Study Reviewed

Yamamoto N, Taito S, Miura T, Ariie T, Tomita Y, Ogihara H, Shiratsuchi D, Yorifuji T, Tsujimoto Y

Journal of Clinical Medicine 12 ( 22 ) 7031 - 7031 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Systematic reviews (SRs) with complete reporting or rigorous methods can lead to less biased recommendations and decisions. A comprehensive analysis of the epidemiological and reporting characteristics of SRs in orthopedics is lacking. We evaluated 360 SRs, including 165 and 195 published in orthopedic journals in 2012 and 2022. According to the established reporting guidelines, we examined these SRs for key epidemiological characteristics, including focus areas, type of meta-analysis (MA), and reporting characteristics. Most SRs (71%) were therapy-related, with a significant proportion originating from authors in the USA, UK, and China. Pairwise MA was performed on half of the SRs. The proportion of protocol registrations improved by 2022 but remained low (33%). Despite a formal declaration of adherence to the reporting guidelines (68%), they were often not used and reported enough. Only 10% of the studies used full search strategies, including trial registries. Publication bias assessments, subgroup analyses, and sensitivity analyses were not even planned. The risk of bias assessment improved in 2022; however, the certainty of the evidence remained largely unassessed (8%). The use and reporting of standard methods in orthopedic SRs have remained suboptimal. Thus, authors, peer reviewers, journal editors, and readers should criticize the results more.

DOI： 10.3390/jcm12227031

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Association between infant breastfeeding practices and timing of peak height velocity: A nationwide longitudinal survey in Japan. Reviewed

Higuchi Y, Matsumoto N, Fujiwara S, Ebuchi Y, Furujo M, Nakamura K, Kubo T, Yorifuji T

Pediatr Res. 94 ( 5 ) 1845 - 1854 2023.11

Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review Reviewed

Tsuge M, Uda K, Eitoku T, Matsumoto N, Yorifuji T, Tsukahara H

Int J Mol Sci. 24 ( 20 ) 15450 - 15450 2023.10

Effectiveness of the original COVID-19 vaccine in preventing COVID-19 exacerbations during the Omicron wave: A population-based study in Okayama, Japan. Reviewed

Matsumoto N, Mitsuhashi T, Matsuo R, Kadowaki T, Takao S, Yorifuji T

JMA J. 6 ( 4 ) 463 - 46 2023.10

Does Participation in the Setouchi Triennale Foster Social Capital? : A Cross-Sectional Study Reviewed

Miyaji C, Takao S, Habu H, Matsumoto N, Aoo K, Nishita Y, Tsuri M, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 443 - 449 2023.10

Childcare and Child Development in Japan. Reviewed

Murata A, Matsumoto N, Miyaji C, Takao S, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 479 - 490 2023.10

Participation in the Setouchi Triennale and the Health of Residents in Naoshima: A Cross-Sectional Study Reviewed

Habu H, Takao S, Miyaji C, Matsumoto N, Aoo K, Nishita Y, Tsuri M, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 491 - 497 2023.10

Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study Reviewed

Kei Tamai, Naomi Matsumoto, Takashi Yorifuji, Akihito Takeuchi, Makoto Nakamura, Kazue Nakamura, Misao Kageyama

Scientific Reports 13 ( 1 ) 14990 - 14990 2023.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

The purpose of this study was to assess the associations between delivery room intubation (DRI) and severe intraventricular hemorrhage (IVH), as well as other neonatal outcomes, among extremely preterm infants without low Apgar scores using data from a large-scale neonatal registry data in Japan. We analyzed data for infants born at 24–27 gestational weeks between 2003 and 2019 in Japan using robust Poisson regression. Infants with low Apgar scores (≤ 1 at 1 min or ≤ 3 at 5 min) were excluded. The primary outcome was severe IVH. Secondary outcomes were other neonatal morbidities and mortality. The full cohort included 16,081 infants (intubation cohort, 13,367; no intubation cohort, 2714). The rate of DRI increased over time (78.6%, 2003–2008; 83.4%, 2009–2014; 87.8%, 2015–2019), while the rate of severe IVH decreased (7.1%, 2003–2008; 5.7%, 2009–2014; 5.3%, 2015–2019). Infants with DRI had a higher risk of severe IVH than those without DRI (6.8% vs. 2.3%; adjusted risk ratio, 1.86; 95% confidence interval, 1.33–2.58). The results did not change substantially when stratified by gestational age. Despite conflicting changes over time in DRI and severe IVH, DRI was associated with an increased risk of severe IVH among extremely preterm infants in Japan.

DOI： 10.1038/s41598-023-41010-x

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Other Link： https://www.nature.com/articles/s41598-023-41010-x

Antibody Titers After a Third and Fourth SARS-CoV-2 Vaccine Dose in Bizen City, Japan Reviewed

Tomoka Kadowaki, Ayako Sasaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Journal of Epidemiology 33 ( 9 ) 484 - 486 2023.9

Association between handwashing and gargling education for children and prevention of respiratory tract infections: a longitudinal Japanese children population-based study. Reviewed

Uraguchi K, Mitsuhashi T, Matsumoto N, Takao S, Makihara S, Ando M, Yorifuji T

Eur J Pediatr. 182 ( 9 ) 4037 - 4047 2023.9

A population-based longitudinal study on glycated hemoglobin levels and new-onset chronic kidney disease among non-diabetic Japanese adults Reviewed

Yukari Okawa, Etsuji Suzuki, Toshiharu Mitsuhashi, Toshihide Tsuda, Takashi Yorifuji

Scientific Reports 13 ( 1 ) 13770 - 13770 2023.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the relationship between HbA1c levels and subsequent CKD development in greater detail than previous studies. Longitudinal data of annual checkups of 7176 Japanese non-diabetic people (male: 40.4%) from 1998 to 2022 was analyzed. HbA1c values were categorized into < 5.0%, 5.0–5.4%, 5.5–5.9%, and 6.0–6.4%. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m². The descriptive statistics at study entry showed that higher HbA1c values were associated with male, older, overweight or obese, hypertensive, or dyslipidemic people. During a mean follow-up of 7.75 person-years, 2374 participants (male: 40.0%) developed CKD. The Weibull accelerated failure time model was selected because the proportional hazards assumption was violated. The adjusted time ratios of developing CKD for HbA1c levels of 5.5–5.9% and 6.0–6.4% compared with 5.0–5.4% were 0.97 (95% confidence interval: 0.92–1.03) and 1.01 (95% confidence interval: 0.90–1.13), respectively. There was no association between HbA1c in the prediabetic range and subsequent CKD development.

DOI： 10.1038/s41598-023-40300-8

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Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan Reviewed

Kataoka Takahiro, Habu Hiroshi, Tanaka Ayumi, Naoe Shota, Murakami Kaito, Fujimoto Yuki, Yukimine Ryohei, Takao Soshi, Mitsunobu Fumihiro, Yorifuji Takashi, Yamaoka Kiyonori

Acta Med Okayama. 77 ( 4 ) 387 - 394 2023.8

Effect of 2-week postpartum check-ups on screening positive for postpartum depression: a population-based cohort study using instrumental variable estimation in Japan. Reviewed

Nakamura N, Mitsuhashi T, Nakashima Y, Matsumoto N, Yorifuji T

Fam Pract. cmad074 2023.7

Longitudinal impact of the COVID-19 pandemic on the development of mental disorders in preadolescents and adolescents Reviewed

Matsumoto N, Kadowaki T, Takanaga S, Shigeyasu Y, Okada A, Yorifuji T

BMC Public Health 23 ( 1 ) 1308 - 1308 2023.7

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

School closures and social distancing may have affected mental health among preadolescent and adolescent children, who are in a social developmental stage. Rates of anxiety, depression, and stress have been reported to have increased during the COVID-19 pandemic among teenagers worldwide. However, most studies have measured children's mental health in cross-sectional studies or short-term comparisons before and after lockdowns and school closures, and few studies have tracked the long-term effects on mental health among children and adolescents, despite the pandemic lasting more than 2 years.

Methods

An interrupted time-series analysis was performed for longitudinal changes in the monthly number of new mental disorders (eating disorders, schizophrenia, mood disorders, and somatoform disorders). Using a nationwide multicenter electronic health records database in Japan, we analyzed data of patients aged 9 to 18 years from 45 facilities that provided complete data throughout the study period. The study period covered January 2017 to May 2021, defining a national school closure as an intervention event. We modeled the monthly new diagnoses of each mental disorder using a segmented Poisson regression model.

Results

The number of new diagnoses throughout the study period was 362 for eating disorders, 1104 for schizophrenia, 926 for mood disorders, and 1836 for somatoform disorders. The slope of the regression line in monthly number of new diagnoses increased in the post-pandemic period for all targeted mental disorders (change in slope for eating disorders 1.05, 95% confidence interval [CI] 1.00–1.11; schizophrenia 1.04, 95% CI 1.01–1.07; mood disorders 1.04, 95% CI 1.01–1.07; and somatoform disorders 1.04 95% CI 1.02–1.07). The number of new diagnoses for schizophrenia and mood disorders increased early after school closure; while eating disorders showed an increasing trend several months later. Somatoform disorders showed a decreasing trend followed by an increasing trend. Time trends by sex and age also differed for each mental disorder.

Conclusions

In the post-pandemic period, the number of new cases increased over time for eating disorders, schizophrenia, mood disorders, and somatoform disorders. The timing of increase and trends by sex and age differed for each mental disorder.

DOI： 10.1186/s12889-023-16228-z

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Efficacy of telerehabilitation for patients after hip fracture surgery: A systematic review and meta-analysis. Reviewed

Tsuge T, Yamamoto N, Taito S, Miura T, Shiratsuchi D, Yorifuji T

J Telemed Telecare. 1357633X231181632 2023.7

Prevalence, reasons, and timing of decisions to withhold/withdraw life-sustaining therapy for out-of-hospital cardiac arrest patients with extracorporeal cardiopulmonary resuscitation Reviewed

Hiromichi Naito, Masaaki Sakuraya, Takashi Hongo, Hiroaki Takada, Tetsuya Yumoto, Takashi Yorifuji, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, Atsunori Nakao

Critical Care 27 ( 1 ) 252 - 252 2023.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Extracorporeal cardiopulmonary resuscitation (ECPR) is rapidly becoming a common treatment strategy for patients with refractory cardiac arrest. Despite its benefits, ECPR raises a variety of ethical concerns when the treatment is discontinued. There is little information about the decision to withhold/withdraw life-sustaining therapy (WLST) for out-of-hospital cardiac arrest (OHCA) patients after ECPR.

Methods

We conducted a secondary analysis of data from the SAVE-J II study, a retrospective, multicenter study of ECPR in Japan. Adult patients who underwent ECPR for OHCA with medical causes were included. The prevalence, reasons, and timing of WLST decisions were recorded. Outcomes of patients with or without WLST decisions were compared. Further, factors associated with WLST decisions were examined.

Results

We included 1660 patients in the analysis; 510 (30.7%) had WLST decisions. The number of WLST decisions was the highest on the first day and WSLT decisions were made a median of two days after ICU admission. Reasons for WLST were perceived unfavorable neurological prognosis (300/510 [58.8%]), perceived unfavorable cardiac/pulmonary prognosis (105/510 [20.5%]), inability to maintain extracorporeal cardiopulmonary support (71/510 [13.9%]), complications (10/510 [1.9%]), exacerbation of comorbidity before cardiac arrest (7/510 [1.3%]), and others. Patients with WLST had lower 30-day survival (WLST vs. no-WLST: 36/506 [7.1%] vs. 386/1140 [33.8%], p < 0.001). Primary cerebral disorders as cause of cardiac arrest and higher severity of illness at intensive care unit admission were associated with WLST decisions.

Conclusion

For approximately one-third of ECPR/OHCA patients, WLST was decided during admission, mainly because of perceived unfavorable neurological prognoses. Decisions and neurological assessments for ECPR/OHCA patients need further analysis.

DOI： 10.1186/s13054-023-04534-2

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Other Link： https://link.springer.com/article/10.1186/s13054-023-04534-2/fulltext.html

Neurological and Neurocognitive Impairments in Adults with a History of Prenatal Methylmercury Poisoning: Minamata Disease. Reviewed

Yorifuji T, Kadowaki T, Yasuda M, Kado Y

Int J Environ Res Public Health. 20 ( 12 ) 6172 - 6173 2023.6

Early childhood exposure to maternal smoking and obesity: A nationwide longitudinal survey in Japan. Reviewed International journal

Miho Yamashita, Takashi Yorifuji, Naomi Matsumoto, Toshihide Kubo, Hirokazu Tsukahara

Clinical obesity 13 ( 3 ) e12572 - e12572 2023.6

Language：English Publishing type：Research paper (scientific journal)

Involuntary exposure to tobacco smoke is suspected to be one of the risks factors that are associated with obesity in children. The purpose of this study was to examine the relationship between early childhood exposure to tobacco smoke and the risk of obesity and overweight in Japan. This study utilized a nationwide, population-based longitudinal survey. The participants were restricted to 32 081 children who had available information on maternal smoking history as well as childhood height and weight. We conducted a binomial log-linear regression analysis with children of non-smoking mothers as the reference group. The children with mothers who were smokers had a higher risk of developing obesity or being overweight compared to the children with mothers who were nonsmokers. The risk ratios were 1.20 (95% confidence interval [CI]: 1.09-1.32) for overweight and 1.17 (95% CI: 0.95-1.44) for obesity. Early exposure to maternal smoking increases the risk of being overweight and having obesity during childhood. The increased risk is more pronounced among children with mothers, smoked heavily, or parents, who were smokers.

DOI： 10.1111/cob.12572

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Quality of life and physical/psychosocial factors in children and adolescents with orthostatic intolerance. Reviewed

Shigeyasu Y, Okada A, Fujii C, Tanaka C, Sugihara A, Horiuchi M, Yorifuji T, Tsukahara H

Biopsychosoc Med. 17 ( 1 ) 23 - 23 2023.6

Association of Prehospital Physician Presence During Pediatric Out-of-Hospital Cardiac Arrest With Neurologic Outcomes Reviewed

Takafumi Obara, Tetsuya Yumoto, Tsuyoshi Nojima, Takashi Hongo, Kohei Tsukahara, Naomi Matsumoto, Takashi Yorifuji, Atsunori Nakao, Jonathan Elmer, Hiromichi Naito

Pediatric Critical Care Medicine 24 ( 5 ) e244 - e252 2023.5

Disease and Injury Trends following Heavy Rains in Western Japan in 2018. Reviewed

Hashimoto C, Yorifuji T, Murakami K, Suganami S

JMA J. 6 ( 2 ) 129 - 137 2023.4

Association between prehospital advanced life support by emergency medical services personnel and neurological outcomes among adult out-of-hospital cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study. Reviewed

Yumoto T, Hongo T, Hifumi T, Inoue A, Sakamoto T, Kuroda Y, Yorifuji T, Nakao A, Naito H, SAVE‐J II study group

J Am Coll Emerg Physicians Open. 4 ( 2 ) e12948 - e12948 2023.4

Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department. Reviewed

Inaba M, Naito H, Yorifuji T, Nakamichi C, Maeyama H, Ishikawa H, Shime N, Uemori S, Ishihara S, Takaoka M, Ohtsuka T, Harada M, Nozaki S, Kohama K, Sakurai R, Sato S, Muramatsu S, Yamashita K, Mayumi T, Aita K, Nakao A, he LIFE Study Investigators

Sci Rep. 13 ( 1 ) 5433 - 5433 2023.4

Frailty and all-cause and cause-specific mortality in Japan Reviewed

Rumi Matsuo, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Archives of Gerontology and Geriatrics 107 104906 - 104906 2023.4

Evaluating the Coping Behavior of Children with Psychosomatic Disorders under Frustrating Situations Simulated Using the Rosenzweig Picture-Frustration Study. Reviewed

Sugihara A, Okada A, Horiuchi M, Yabe M, Shigeyasu Y, Fujii C, Tanaka C, Yorifuji T, Tsukahara H

Acta Med Okayama. 77 ( 2 ) 185 - 192 2023.4

Evaluation of the association of birth order and group childcare attendance with Kawasaki disease using data from a nationwide longitudinal survey. Reviewed

Namba T, Takeuchi A, Matsumoto N, Tsuge M, Yashiro M, Tsukahara H, Yorifuji T

Front Pediatr. 11 1127053 - 1127053 2023.3

Heat Exposure Following the Rainy Season Is Associated With an Increased Risk of Cardiovascular Emergency Among the Elderly in Japan. Reviewed

Fujimoto R, Suzuki E, Kashima S, Nakamura K, Naito H, Nakao A, Ito H, Yorifuji T

J Am Heart Assoc. 12 ( 6 ) e027046 - e027046 2023.3

Adverse Reactions and Attitudes Toward the BNT162b2 COVID-19 Vaccine in Children 5 to 11 Years of Age in Japan Reviewed

Naomi Matsumoto, Junya Shimizu, Yuji Yokoyama, Hirokazu Tsukahara, Takashi Yorifuji

Journal of Epidemiology 33 ( 2 ) 110 - 111 2023.2

Do Complementary and Alternative Medicine Users Also Use Conventional Medicine? A Repeated Cross-Sectional Study in Japan from 1995 to 2013. Reviewed International journal

Nobuyoshi Matsuki, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Journal of integrative and complementary medicine 29 ( 2 ) 119 - 126 2023.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Introduction: It is recommended that users of complementary and alternative medicine (CAM) also seek conventional medical care to prevent the loss of access to appropriate medical care. However, the status of such use is unknown. The aim of this study was to examine the time trends in the proportion of CAM users who also receive conventional medical care for the same symptoms. Methods: This is a repeated cross-sectional study. Of data for 753,978 respondents to the Comprehensive Survey of Living Conditions, which was conducted seven times between 1995 and 2013, data from 17,707 individuals who used acupuncture, moxibustion, anma-massage-shiatsu, or judo therapy were analyzed. Cross-classified multilevel logistic regression models with individuals as level 1 and survey year and cohort as level 2 were used to calculate odds ratios (ORs) and 95% credible intervals (CIs) for combined use of CAM and conventional medical care. Age was entered as an individual-level variable. The period effect after 2003 was entered as a survey year-level variable because the number of eligible persons providing CAM treatments has increased since 2003. Results: Among the 17,707 CAM users, 11,567 (65.3%) were women. When age was entered as an explanatory variable, the results showed that both older men and women tended to receive conventional medical care (women, OR: 1.04, 95% CI: 1.03-1.04; men, OR: 1.03, 95% CI: 1.02-1.04). Additional examination of the possible period effect after 2003 showed a positive (although nonsignificant) association (women, OR: 1.36, 95% CI: 0.89-1.99; men, OR: 1.37, 95% CI: 0.94-1.91). Conclusions: As patient age increased, patients combined CAM use with conventional medicine. The findings also suggested that the combined use of CAM and conventional medicine has increased since 2003.

DOI： 10.1089/jicm.2022.0631

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Examining the association between vaccine reactogenicity and antibody titer dynamics after the third dose of BNT162b2 vaccine using a mixed-effects model Reviewed

Naomi Matsumoto, Hideharu Hagiya, Masanori Nakayama, Masanori Furukawa, Toshiharu Mitsuhashi, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

Journal of Infection and Chemotherapy 29 ( 1 ) 39 - 42 2023.1

Breastfeeding at 6 months of age had a positive impact on overweight and obesity in Japanese adolescents at 15 years of age. Reviewed International journal

Tomoka Kadowaki, Naomi Matsumoto, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Acta paediatrica (Oslo, Norway : 1992) 112 ( 1 ) 106 - 114 2023.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

AIM: A number of studies have indicated the potential benefits that breastfeeding has on reducing childhood obesity, but few studies have evaluated the effect on adolescent obesity. We examined the association between breastfeeding and overweight or obesity at 15 years of age using data from a large nationwide longitudinal study launched by the Japanese Government in 2001. METHODS: We analysed data for 26 164 participants with known infant feeding practices at 6 months of age, namely the duration of breastfeeding or formula feeding. Overweight or obesity at 15 years of age were calculated based on the subject's self-reported height and weight. Multinomial logistic regression analysis adjusted the data for child factors, namely sex, siblings, birth weight and physical activity clubs and the maternal factors of age, educational attainment and smoking status. RESULTS: Formula feeding was associated with an increased risk of overweight or obesity at 15 years of age. The adjusted odds ratios (95% confidence intervals) were 0.99 (0.89-1.09) for partial breastfeeding and 1.23 (1.02-1.48) for formula feeding, when exclusive breastfeeding was the reference category. CONCLUSION: Breastfeeding during infancy had potential benefits for overweight or obesity among 15-year-old adolescents. Our results provide further evidence of the importance of breastfeeding.

DOI： 10.1111/apa.16551

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Adverse reactions in young children receiving the coronavirus disease 2019 vaccine Reviewed

Matsumoto N, Shimizu J, Yokoyama Y, Tsukahara H, Yorifuji T

Pediatrics International 65 ( 1 ) e15696 - e15696 2023.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Background

We sought to investigate the occurrence of adverse reactions in Japanese children aged 6 months to 4 years who received the BNT162b2 coronavirus disease 2019 (COVID‐19) vaccine, to examine parental considerations, and to evaluate potential risk factors associated with post‐vaccination fever.

Methods

This cross‐sectional survey study targeted 1617 children aged 6 months to 4 years who received their primary doses of BNT162b2 from November 10, 2022, to April 30, 2023, in Okayama Prefecture. We surveyed the occurrence of local and systemic reactions within 1 week after vaccination, and described the incidence proportions of adverse reactions for 515 participants overall and by age group. The study also examined the impact of previous COVID‐19 infection and co‐administration of the seasonal influenza vaccine on post‐vaccination fever. A survey also assessed parents' reasons for vaccinating their children and the sources of information they used.

Results

Adverse reactions were infrequent (5.2%, with fever ≥37.5°C; no cases exceeded 39°C) and did not increase with vaccine doses administered. The risk of post‐vaccination fever was not statistically associated with a history of COVID‐19—the adjusted risk ratio (aRR) was 0.99, and the 95% confidence interval (CI) was 0.41–2.39—but was associated with co‐administration of the seasonal influenza vaccine (aRR 3.24, 95% CI 1.14–9.18). Parental decisions regarding vaccination were influenced by official government guidelines and primary care physicians' opinion.

Conclusion

This study provides valuable insight into the safety profile of the BNT162b2 vaccine in Japanese children aged 6 months to 4 years. Further research involving larger cohorts and appropriate control groups is needed.

DOI： 10.1111/ped.15696

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Exposure to fine particulate matter and acute upper- and lower-respiratory tract infections (AURI and ALRI) in children under five years of age in India Reviewed

Kawuli Abudureyimu, Made Ayu Hitapretiwi Suryadhi, Takashi Yorifuji, Toshihihe Tsuda

Archives of Environmental & Occupational Health 78 ( 1 ) 1 - 6 2023

Exposure of Ambient PM 2.5 and Acute Upper-and Lower Respiratory Infection in Children Under the Age of Five in South and Southeast Asia Reviewed

Suryadhi Made Ayu Hitapretiwi, Abudureyimu Kawuli, Ekawati Ni Komang, Ruma I Made Winarsa, Suryadhi Putu Ayu Rhamani, Yorifuji Takashi

Asian Journal of Water, Environment and Pollution 20 ( 2 ) 41 - 49 2023

Differential Associations of Frailty with the Incidence of Mild and Severe Disabilities in Older Adults: A 3-Year Cohort Study Reviewed

Akikazu Hagiyama, Soshi Takao, Rumi Matsuo, Takashi Yorifuji

Annals of Geriatric Medicine and Research 26 ( 4 ) 309 - 315 2022.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：The Korean Geriatrics Society

Background: Frailty is associated with the incidence of disability in older adults; however, few studies have investigated differences in the association of frailty with mild and severe disabilities according to Japanese long-term care insurance certification. This study separately investigated the associations between frailty and the incidence of mild and severe disabilities.Methods: This 3-year retrospective cohort study included community-dwelling adults in Okayama City aged ≥65 years. We assessed frailty status using the Kihon Checklist and defined the outcomes as mild and severe disabilities according to long-term care insurance certifications. We applied multinomial logistic regression analysis to investigate the association between frailty and the incidence of mild and severe disabilities.Results: The analysis included a total of 36,043 participants. For mild disability, the odds ratios (ORs) comparing frail to robust and prefrail to robust were 3.85 (95% confidence interval [CI], 3.36–4.42) and 1.82 (95% CI, 1.58–2.10), respectively. Similarly, the corresponding ORs for severe disability were 4.35 (95% CI, 3.55–5.34) and 1.78 (95% CI, 1.43–2.21), respectively. In the age-stratified analysis of mild disability, the pre-old group (aged 65–74 years) with frail showed a higher association than the old-age group (aged ≥75 years) with frail. Regarding severe disability, the older group with frailty showed a higher association than the pre-old group with frailty.Conclusion: The results showed that both prefrail and frail were associated with the incidence of mild and severe disabilities, with different patterns of association between the pre-old and old age groups.

DOI： 10.4235/agmr.22.0097

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Association Between Fever and Antibody Titer Trends After a Third Dose of the mRNA-1273 Vaccine. Reviewed

Naomi Matsumoto, Tomoka Kadowaki, Rumi Matsuo, Ayako Sasaki, Chikara Miyaji, Chigusa Higuchi, Masanori Nakayama, Yasue Sakurada, Hideharu Hagiya, Soshi Takao, Fumio Otsuka, Takashi Yorifuji

Journal of epidemiology 32 ( 12 ) 567 - 569 2022.12

Impact of COVID-19 pandemic-associated reduction in respiratory viral infections on childhood asthma onset in Japan Reviewed International journal

Naomi Matsumoto, Tomoka Kadowaki, Satoe Takanaga, Masanori Ikeda, Takashi Yorifuji

The Journal of Allergy and Clinical Immunology: In Practice 10 ( 12 ) 3306 - 3308.e2 2022.12

Early-stage antibody kinetics after the third dose of BNT162b2 mRNA COVID-19 vaccination measured by a point-of-care fingertip whole blood testing. Reviewed International journal

Hideharu Hagiya, Yasuhiro Nakano, Masanori Furukawa, Naruhiko Sunada, Toru Hasegawa, Yasue Sakurada, Kou Hasegawa, Koichiro Yamamoto, Hiroko Ogawa, Takafumi Obara, Kouhei Ageta, Naomi Matsumoto, Rumi Matsuo, Tomoka Kadowaki, Akihito Higashikage, Takao Hikita, Takashi Yorifuji, Shinichi Toyooka, Yoshinobu Maeda, Yoshinori Yokokura, Fumio Otsuka, Masanori Nakayama

Scientific reports 12 ( 1 ) 20628 - 20628 2022.11

Language：English Publishing type：Research paper (scientific journal)

Amid the Coronavirus Disease 2019 pandemic, we aimed to demonstrate the accuracy of the fingertip whole blood sampling test (FWT) in measuring the antibody titer and uncovering its dynamics shortly after booster vaccination. Mokobio SARS-CoV-2 IgM & IgG Quantum Dot immunoassay (Mokobio Biotechnology R&D Center Inc., MD, USA) was used as a point-of-care FWT in 226 health care workers (HCWs) who had received two doses of the BNT162b2 mRNA vaccine (Pfizer-BioNTech) at least 8 months prior. Each participant tested their antibody titers before and after the third-dose booster up to 14-days. The effect of the booster was observed as early as the fourth day after vaccination, which exceeded the detection limit (> 30,000 U/mL) by 2.3% on the fifth day, 12.2% on the sixth day, and 22.5% after the seventh day. Significant positive correlations were observed between the pre- and post-vaccination (the seventh and eighth days) antibody titers (correlation coefficient, 0.405; p < 0.001). FWT is useful for examining antibody titers as a point-of-care test. Rapid response of antibody titer started as early as the fourth day post-vaccination, while the presence of weak responders to BNT162b2 vaccine was indicated.

DOI： 10.1038/s41598-022-24464-3

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Glasgow‐Blatchford score combined with nasogastric aspirate as a new diagnostic algorithm for patients with nonvariceal upper gastrointestinal bleeding Reviewed

Toshiyuki Wakatsuki, Tomohiko Mannami, Shinichi Furutachi, Hiroki Numoto, Tsuyoshi Umekawa, Mayu Mitsumune, Tsukasa Sakaki, Hanako Nagahara, Yasushi Fukumoto, Takashi Yorifuji, Shin'ichi Shimizu

DEN Open 3 ( 1 ) e185 - e185 2022.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Objectives

The Glasgow‐Blatchford score (GBS) is a widely used risk assessment tool for patients with upper gastrointestinal bleeding. However, it only identifies a relatively low proportion of patients at low risk for adverse events and poor outcomes. We developed a simple diagnostic algorithm combining the GBS and nasogastric aspirate and evaluated its diagnostic performance.

Methods

A total of 115 consecutive patients with suspected nonvariceal upper gastrointestinal bleeding who underwent nasogastric tube placement and upper endoscopy at our emergency department were prospectively evaluated. We compared the diagnostic accuracy of the GBS and our algorithm for predicting high‐risk endoscopic lesions (HRELs) using receiver operating characteristic curve analysis.

Results

Thirty‐five patients had HRELs. Compared with the GBS, our algorithm showed superior performance with respect to the prediction of HRELs (area under the curve, 0.639 and 0.854, respectively; p < 0.001). With set optimal threshold values, the algorithm identified a significantly higher proportion of patients who did not have HRELs than the GBS (23.5% vs. 2.6%, p < 0.001).

Conclusions

The novel algorithm has improved the diagnostic performance of the GBS and predicted more patients who did not have HRELs than the GBS alone. After further validation, it may be a useful tool for making clinical management decisions for patients with nonvariceal upper gastrointestinal bleeding.

DOI： 10.1002/deo2.185

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Timing of REGEN-COV administration and progression to severe COVID-19 Reviewed

Tomoka Kadowaki, Sato Imajou, Naomi Matsumoto, Soshi Takao, Takashi Yorifuji

Journal of Infection and Chemotherapy 28 ( 11 ) 1459 - 1463 2022.11

Poor vaccine responsiveness towards third-dose mRNA vaccine of COVID-19 in Japanese older people Reviewed

Hideharu Hagiya, Takao Hikita, Tomohiro Habu, Masaki Asada, Takashi Yorifuji, Shinichi Toyooka, Fumio Otsuka, Masanori Nakayama

Journal of Infection 85 ( 4 ) 436 - 480 2022.10

Oral cleaning habits and the copy number of periodontal bacteria in pregnant women and its correlation with birth outcomes: an epidemiological study in Mibilizi, Rwanda Reviewed

Hiroaki Arima, Akintije Simba Calliope, Hideki Fukuda, Theoneste Nzaramba, Marie Goretti Mukakarake, Takayuki Wada, Takashi Yorifuji, Leon Mutesa, Taro Yamamoto

BMC Oral Health 22 ( 1 ) 428 - 428 2022.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Since 1996, many studies have reported that periodontal disease during pregnancy may be a risk factor for preterm birth and low birth weight; however, in Africa, periodontal disease is considered a non-high-priority disease. In addition, there are few dental facilities in rural Rwanda; thus, the oral condition of pregnant women has not been investigated. The objective of this study was to assess the tooth brushing habits of pregnant women in rural Rwanda and evaluate whether periodontal bacteria in the oral cavity of pregnant women are related to birth outcomes or oral cleaning habits.

Methods

A questionnaire survey and saliva collection were conducted for pregnant women in the catchment area population of Mibilizi Hospital located in the western part of Rwanda. Real-time PCR was performed to quantitatively detect total bacteria and 4 species of periodontal bacteria. The relationship of the copy number of each bacterium and birth outcomes or oral cleaning habits was statistically analyzed.

Results

Among the participants, high copy numbers of total bacteria, Tannerella forsythia, and Treponema denticola were correlated with lower birth weight (p = 0.0032, 0.0212, 0.0288, respectively). The sex ratio at birth was higher in women who had high copy numbers of Porphyromonas gingivalis and T. denticola during pregnancy (p = 0.0268, 0.0043). Furthermore, regarding the correlation between oral cleaning habits and the amount of bacteria, the more frequently teeth were brushed, the lower the level of P. gingivalis (p = 0.0061); the more frequently the brush was replaced, the lower the levels of P. gingivalis and T. forsythia (p = 0.0153, 0.0029).

Conclusions

This study suggested that improving tooth brushing habits may reduce the risk of periodontal disease among pregnant women in rural Rwanda. It also indicated that the amount of bacteria is associated with various birth outcomes according to the bacterial species. Both access to dental clinics and the oral cleaning habits of pregnant women should be important considerations in efforts to alleviate reproductive-related outcomes in rural Africa.

DOI： 10.1186/s12903-022-02443-4

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Correlation Between National Surveillance and Search Engine Query Data on Respiratory Syncytial Virus Infections in Japan Reviewed

Kazuhiro Uda, Hideharu Hagiya, Takashi Yorifuji, Toshihiro Koyama, Mitsuru Tsuge, Masato Yashiro, Hirokazu Tsukahara

BMC Public Health. 22 ( 1 ) 1517 - 1517 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Research Square Platform LLC

Abstract

BackgroundThe respiratory syncytial virus (RSV) disease burden is significant, especially in infants and patients with an underlying disease, and prophylaxis with palivizumab is recommended for these high-risk groups. Early recognition of a RSV epidemic is important for timely administration of palivizumab. We herein aimed to assess the correlation between national surveillance and Google Trends data pertaining to RSV infections in Japan.MethodsThe retrospective survey was performed between January 1, 2018, and November 14, 2021, and evaluated the correlation of national surveillance and Google Trends data. Joinpoint regression was used to analyze the data to evaluate the points at which changes in trends occurred. ResultsAs a result, a strong correlation was observed every study year (2018 [r=0.87, p<0.01], 2019 [r=0.83, p<0.01], 2020 [r=0.83, p<0.01], and 2021 [r=0.96, p<0.01]). The change-points in the Google Trends data indicating the start of the RSV epidemic in 2018 and 2021 were observed earlier than by sentinel surveillance and in 2019 and 2020 simultaneously with sentinel surveillance.ConclusionsOur data suggested that Google Trends has the potential to enable early identification of the RSV epidemic. In countries without a national surveillance system, Google Trends may serve as an alternative early warning system.

DOI： 10.21203/rs.3.rs-1332314/v1

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Association between Immediate Postoperative Radiographic Findings and Failed Internal Fixation for Trochanteric Fractures: Systematic Review and Meta-Analysis Reviewed

Norio Yamamoto, Yasushi Tsujimoto, Suguru Yokoo, Koji Demiya, Madoka Inoue, Tomoyuki Noda, Toshifumi Ozaki, Takashi Yorifuji

Journal of Clinical Medicine 11 ( 16 ) 4879 - 4879 2022.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Failed internal fixations for trochanteric fractures have a strong negative impact owing to increased postoperative mortality and high medical costs. However, evidence on the prognostic value of postoperative radiographic findings for failed internal fixations is limited. We aimed to clarify the association between comprehensive immediate postoperative radiographic findings and failed internal fixation using relative and absolute risk measures. We followed the meta-analysis of observational studies in epidemiology guidelines and the Cochrane handbook. We searched specific databases in November 2021. The outcomes of interest were failed internal fixation and cut-out. We pooled the odds ratios and 95% confidence intervals using a random-effects model and calculated the number needed to harm for each outcome. Thirty-six studies involving 8938 patients were included. The certainty of evidence in the association between postoperative radiographic findings and failed internal fixation or cut-out was mainly low or very low except for the association between intramedullary malreduction on the anteromedial cortex and failed internal fixation. Moderate certainty of evidence supported that intramedullary malreduction on the anteromedial cortex was associated with failed internal fixation. Most postoperative radiographic findings on immediate postoperative radiographs for trochanteric fractures were uncertain as prognostic factors for failed internal fixations.

DOI： 10.3390/jcm11164879

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Standardized incidence ratios of malignant neoplasms among patients with pneumoconiosis Reviewed

Tatsuya Michibata, Takashi Yorifuji

Occupational Medicine 72 ( 6 ) 378 - 385 2022.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Patients with pneumoconiosis, such as silicosis and asbestosis, have a high risk of lung cancer. However, whether these patients are at high risk for neoplasms other than lung cancer and mesothelioma remains inconclusive.

Aims

To examine whether patients with pneumoconiosis have a higher incidence of malignant neoplasms other than lung cancer.

Methods

We conducted a cohort study using the medical records of patients with pneumoconiosis who visited our two hospitals from 1 January 1991 through 31 December 2017. We identified the occurrence of malignant neoplasms and calculated the incidences and standardized incidence ratios (SIRs) compared with those of the general population.

Results

One hundred and seventy patients with pneumoconiosis (163 men, 7 women) including 142 patients with silicosis, 24 with asbestosis and 4 with pneumoconiosis were identified. The mean age was 66.8 years. The proportion of smokers was 79%. Forty-seven malignant neoplasms occurred. Most malignant neoplasms were lung cancer (n = 22), while some were digestive cancers such as gastric cancer (n = 9), oesophageal cancer (n = 3) and colorectal cancer (n = 3). Participants presented increased risks for lung cancer (SIR: 10.86, 95% confidence interval [CI]: 7.15–16.49), gastric cancer (SIR: 2.55, 95% CI: 1.22–5.35) and oesophageal cancer (SIR: 5.78, 95% CI: 1.86–17.92).

Conclusions

Compared with the general population, patients with pneumoconiosis had an increased risk of malignant neoplasms of the digestive system in addition to lung cancer. Clinicians should consider testing for digestive system cancers as well as for lung cancers in these patients.

DOI： 10.1093/occmed/kqac011

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Preterm birth and Kawasaki disease: a nationwide Japanese population-based study. Reviewed International journal

Akihito Takeuchi, Takahiro Namba, Naomi Matsumoto, Kei Tamai, Kazue Nakamura, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Hirokazu Tsukahara, Takashi Yorifuji

Pediatric research 92 ( 2 ) 557 - 562 2022.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Previous studies showed that preterm birth increased the risk for hospital admissions in infancy and childhood due to some acute diseases. However, the risk of preterm children developing Kawasaki disease remains unknown. In the present study, we investigate whether preterm birth increased the morbidity of Kawasaki disease. METHODS: We included 36,885 (34,880 term and 2005 preterm) children born in 2010 in Japan. We examined the association between preterm birth and hospitalization due to Kawasaki disease using a large nationwide survey in Japan. RESULTS: In log-linear regression models that were adjusted for children's characteristics (sex, singleton birth, and parity), parental characteristics (maternal age, maternal smoking, paternal smoking, maternal education, and paternal income), and residential area, preterm infants were more likely to be hospitalized due to Kawasaki disease (adjusted risk ratio: 1·55, 95% confidence interval: 1.01-2.39). We then examined whether breastfeeding status modified the potential adverse effects of preterm birth on health outcome. Preterm infants with partial breastfeeding or formula feeding had a significantly higher risk of hospitalization due to Kawasaki disease compared with term infants with exclusive breastfeeding. CONCLUSIONS: Preterm infants were at a high risk for Kawasaki disease, and exclusive breastfeeding might prevent this disease among preterm infants. IMPACT: Previous studies showed that preterm birth increased the risk for hospital admissions in infancy and childhood due to some acute diseases, however, the risk of preterm children developing Kawasaki disease remains unknown. This Japanese large population-based study showed that preterm infants were at a high risk for Kawasaki disease for the first time. Furthermore, this study suggested that exclusively breastfeeding might prevent Kawasaki disease among preterm infants.

DOI： 10.1038/s41390-021-01780-4

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Sports participation and preterm birth: a nationwide birth cohort in Japan. Reviewed International journal

Kei Tamai, Naomi Matsumoto, Akihito Takeuchi, Makoto Nakamura, Kazue Nakamura, Misao Kageyama, Yosuke Washio, Hirokazu Tsukahara, Takashi Yorifuji

Pediatric research 92 ( 2 ) 572 - 579 2022.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Children born preterm may be less physically active than children born term because of neurocognitive problems, reduced lung function, and poor physical fitness. We evaluated sports participation of children and adolescents who had been born preterm (<37 weeks) and early term (37-38 weeks) in 2001. METHODS: Data from a nationwide longitudinal survey (n = 47,015, including 2375 children born preterm) were analyzed. As indicators of sports participation, we used responses to questions about participation in sports clubs at 7 and 10 years old and in extracurricular school sports at 15 years old. RESULTS: Children born very preterm (25-31 weeks) and moderately to late preterm (32-36 weeks) were less likely to participate in sports clubs at 7, 10, and 15 years old than children born full term (39-41 weeks). Compared with children born full term, the adjusted risk ratios for participation in extracurricular school sports at 15 years old were 0.86 (95% confidence interval: 0.75-0.98) for children born very preterm, 0.92 (0.88-0.97) for children born moderately to late preterm, and 1.00 (0.98-1.02) for children born early term. CONCLUSIONS: Our findings suggest that preterm birth is associated with less participation in organized sports during childhood and adolescence than full-term birth. IMPACT: Research investigating associations between preterm birth and physical activity among children born in the 2000s is limited. This study shows that preterm birth was associated with less participation in organized sports during childhood and adolescence than full-term birth, especially in boys, and the participation in organized sports of children born preterm decreased as gestation shortened. During childhood, boys born early term were also less likely to participate in organized sports than boys born full term, suggesting a continuum with preterm births. These findings offer important additional insights into the limited evidence available for predicting future health outcomes for preterm infants.

DOI： 10.1038/s41390-021-01808-9

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Neonatal sepsis and Kawasaki disease Reviewed

Akihito Takeuchi, Noriko Sugino, Takahiro Namba, Kei Tamai, Kazue Nakamura, Makoto Nakamura, Misao Kageyama, Takashi Yorifuji, Motoki Bonno

European Journal of Pediatrics 181 ( 8 ) 2927 - 2933 2022.8

Social Capital and Post-traumatic Stress Disorder among Heavy Rainfall and Flood Victims in Japan. Reviewed

Miyaji C, Takao S, Noguchi M, Okazaki T, Sato S, Yorifuji T

Acta Med Okayama. 76 ( 4 ) 439 - 446 2022.8

Effects of Tanden Breathing on Constipation: A Randomized Controlled Trial. Reviewed

Habu H, Mitsuhashi T, Tokinobu A, Yorifuji T, Takao S

Acta Med Okayama 76 ( 4 ) 391 - 398 2022.8

Mid-term (30- to 90-day) neurological changes in out-of-hospital cardiac arrest patients: A nationwide retrospective study (the JAAM-OHCA registry) Reviewed

Hiromichi Naito, Tsuyoshi Nojima, Takashi Yorifuji, Noritomo Fujisaki, Atsunori Nakao

The American Journal of Emergency Medicine 58 27 - 32 2022.8

Adverse reactions and attitudes toward vaccines among young populations one month after receiving a second dose of mRNA-1273 in Japan Reviewed

Naomi Matsumoto, Chigusa Higuchi, Toshiharu Mitsuhashi, Hideharu Hagiya, Soshi Takao, Takashi Yorifuji

Global Health & Medicine 4 ( 2 ) 141 - 143 2022.4

Emotional work stress reactions of emergency medical technicians involved in transporting out-of-hospital cardiac arrest patients with “do not attempt resuscitation” orders Reviewed

Ryo Tanabe, Takashi Hongo, Yasuhiro Mandai, Mototaka Inaba, Takashi Yorifuji, Atsunori Nakao, Jonathan Elmer, Hiromichi Naito

Resuscitation 173 61 - 68 2022.4

Long-term exposure to fine particle matter and all-cause mortality and cause-specific mortality in Japan: the JPHC Study Reviewed

Norie Sawada, Tomoki Nakaya, Saori Kashima, Takashi Yorifuji, Tomoya Hanibuchi, Hadrien Charvat, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Hiroyasu Iso, Shoichiro Tsugane

BMC Public Health 22 ( 1 ) 466 - 466 2022.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Many epidemiological studies have reported the association between exposure to particulate matter and mortality, but long-term prospective studies from Asian populations are sparse. Furthermore, associations at low levels of air pollution are not well clarified. Here, we evaluated associations between long-term exposure to particulate matter <2.5 µg/m³ (PM_2.5) and mortality in a Japanese cohort with a relatively low exposure level.

Methods

The Japan Public Health Center-based Prospective Study (JPHC Study) is a prospective cohort study of men and women aged 40-69 years in 1990 who were followed up through 2013 for mortality. In this cohort of 87,385 subjects who did not move residence during follow-up, average PM_2.5 levels from 1998 to 2013 by linkage with 1-km² grids of PM_2.5 concentration were assigned to the residential addresses of all participants. To avoid exposure misclassification, we additionally evaluated the association between 5-year (1998-2002) cumulative exposure level and mortality during the follow-up period from 2003 to 2013 in 79,078 subjects. Cox proportional hazards models were used to calculate the association of long-term exposure to PM_2.5 on mortality, with adjustment for several individual confounding factors.

Results

Average PM_2.5 was 11.6 µg/m³. Average PM_2.5 exposure was not associated with all-cause mortality or cancer and respiratory disease mortality. However, average PM_2.5 was positively associated with mortality from cardiovascular disease (hazard ratio (HR) of 1.23 (95%CI=1.08-1.40) per 1-µg/m³ increase; in particular, HR in mortality from cerebrovascular disease was 1.34 (95%CI=1.11-1.61) per 1-µg/m³ increase. Additionally, these results using cumulative 5-year PM_2.5 data were similar to those using average PM_2.5 over 15 years.

Conclusions

We found evidence for a positive association between PM_2.5 exposure and mortality from cardiovascular disease in a Japanese population, even in an area with relatively low-level air pollution.

DOI： 10.1186/s12889-022-12829-2

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Effect of mRNA vaccines in preventing COVID-19 severe pneumonia among COVID-19 patients in Japan. Reviewed

Matsuo R, Matsumoto N, Kadowaki T, Mitsuhashi T, Takao S, Yorifuji T

J Epidemiol. 32 ( 3 ) 151 - 152 2022.3

Causal Effect of the Tokyo 2020 Olympic and Paralympic Games on the Number of COVID-19 Cases under COVID-19 Pandemic: An Ecological Study Using the Synthetic Control Method Reviewed

Norio Yamamoto, Toshiharu Mitsuhashi, Yuuki Tsuchihashi, Takashi Yorifuji

Journal of Personalized Medicine 12 ( 2 ) 209 - 209 2022.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Previous studies have not assessed the causal effect of the Olympic Games on the spread of pandemics. Using the synthetic control method and the national public city data in Japan recorded from February to September 2021, we estimated the causal effects of the Tokyo 2020 Olympic and Paralympic Games on the number of coronavirus disease 2019 (COVID-19) cases. The difference between the number of COVID-19 cases in Tokyo and a counterfactual “synthetic Tokyo” (created using synthetic control method) after the opening of the Tokyo 2020 Games (23 July 2021) widened gradually and then considerably over time. It was predicted that the Tokyo 2020 Games increased the number of COVID-19 cases in Tokyo by approximately 469.4 per 100,000 population from the opening of the event to 30 September. However, sensitivity analysis of the ratio of the pre- and post-game root mean square prediction errors using regression weights did not suggest robustness. Our results showed that the Tokyo 2020 Games probably increased the number of COVID-19 cases even under preventive regulations; however, the extent of this increase was difficult to estimate clearly due to an overlap with the fifth wave associated with the Delta variant.

DOI： 10.3390/jpm12020209

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Questionnaire Survey on COVID-19 Vaccination at Okayama University in Japan: Factors Promoting Vaccination Among Young Adults Reviewed

Chigusa Higuchi, Naomi Matsumoto, Yoshiaki Iwasaki, Takashi Yorifuji, Junichiro Yamazaki, Yasutomo Nasu, Hirofumi Makino

Journal of Disaster Research 17 ( 1 ) 21 - 30 2022.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Fuji Technology Press Ltd.

COVID-19 has been prevalent worldwide since 2019. Increasing COVID-19 vaccination coverage is an important measure to combat the disease. An online survey was conducted with university students and personnel who were vaccinated against COVID-19 at a mass vaccination event to examine the factors promoting vaccination among young adults. The online survey was conducted with persons vaccinated at Okayama University from June 5 to September 27, 2021. Although the number of those who had fever >37.5°C increased after the second vaccination compared to the first, the vaccinated persons got more satisfied after the second shot.

DOI： 10.20965/jdr.2022.p0021

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Reusable Medical Isolation Gowns with a Liquid Barrier: Washing Gowns in the Coronavirus Disease 2019 Pandemic Era? Reviewed

Naito H, Tsukahara K, Takao S, Yorifuji T, Nakao A

JMA Journal 5 ( 1 ) 107 - 108 2022.1

Association of nighttime sleep with behaviors in Japanese early childhood. Reviewed International journal

Yusuke Yamauchi, Soshi Takao, Naomi Matsumoto, Takashi Yorifuji

Pediatrics international : official journal of the Japan Pediatric Society 64 ( 1 ) e15354 - e15354 2022.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Preschool children in Asian countries, including Japan, sleep for a shorter duration at night than those in Europe and the USA. We examined the effects of the nighttime sleep duration on behavioral development in early childhood in Japan. METHODS: We used data from a large Japanese nationwide, population-based, longitudinal survey that began in 2001. We restricted the study participants to children born after 37 gestational weeks, with a birth weight ≥ 2500 g and singleton births (n = 41 890). The nighttime sleep duration was examined at 2.5 years old. Responses to survey questions regarding age-appropriate behavior at 5.5 years old were used as indicators of behavioral development. We conducted logistic regression analyses with adjustment for confounding factors, with ≥11 h of nighttime sleep as the reference group. RESULTS: The odds ratios for children who had ≤9 h of nighttime sleep, which was associated with being unable to listen with fidgeting and being unable to remain patient, were 1.26 (95% confidence interval, 1.14-1.39) and 1.27 (1.16-1.38), respectively. Children who had an irregular nighttime sleep duration were associated with age-appropriate behavioral inabilities. These results were similar in children who usually and sometimes took naps to those before stratification by the frequency of napping. CONCLUSION: A short nighttime sleep duration especially affects hyperactivity and impulsivity. An irregular nighttime sleep duration increases the inability to perform overall age-appropriate behaviors more than a short sleep duration. Ensuring a regular and sufficient nighttime sleep duration in early childhood is important for healthy behavioral development.

DOI： 10.1111/ped.15354

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Associations between Early Surgery and Postoperative Outcomes in Elderly Patients with Distal Femur Fracture: A Retrospective Cohort Study. Reviewed

Yamamoto N, Ohbe H, Tomita Y, Yorifuji T, Nakajima M, Sasabuchi Y, Miyamoto Y, Matsui H, Noda T, Yasunaga H

J Clin Med. 10 ( 24 ) 5800 - 5800 2021.12

Alcohol Consumption and Age-related Macular Degeneration: A Systematic Review and Dose-response Meta-analysis. Reviewed International journal

Jingjing Zhang, Toshiharu Mitsuhashi, Toshihiko Matsuo, Takashi Yorifuji, Jun Hamada, Yangyang Liu

Current eye research 46 ( 12 ) 1900 - 1907 2021.12

Language：English Publishing type：Research paper (scientific journal)

Purpose: To perform a systematic review on the association between alcohol consumption and risk of age-related macular degeneration (AMD) using a meta-analytical approach.Method: Systematic literature research was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Both categorical and dose-response meta-analysis was performed separately for early and late AMD. A fixed-effect model was used to calculate pooled effect estimates with 95% confidence interval (CI).Result: Seven studies were included in the analysis with 4,566 and 440 cases of early and late AMD, respectively. Compared to the nondrinkers or occasional drinkers, the pooled effect estimates for early AMD with moderate (1.19, 95% CI [1.03-1.37]) and heavy (1.24, [1.10-1.39]) alcohol consumption, but not light (0.95, [0.90-1.06]) alcohol consumption, were statistically significant. However, the pooled effect estimates for late AMD with light (1.03, [0.79-1.33]), moderate (1.13, [0.83-1.55]), and heavy (0.98, [0.63-1.53]) alcohol consumption were found to be insignificant. A linear dose-response relationship was established (P < .05) between alcohol consumption and risk of early AMD, and the pooled effect estimate for an increase in alcohol consumption of 10 g/day was 1.14 (1.08-1.21).Conclusion: Moderate and heavy alcohol consumption could increase the risk of early AMD, but not late AMD, with a linear dose-response relationship.

DOI： 10.1080/02713683.2021.1942070

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Trajectory of body mass index and height changes from childhood to adolescence: a nationwide birth cohort in Japan. Reviewed International journal

Naomi Matsumoto, Toshihide Kubo, Kazue Nakamura, Toshiharu Mitsuhashi, Akihito Takeuchi, Hirokazu Tsukahara, Takashi Yorifuji

Scientific reports 11 ( 1 ) 23004 - 23004 2021.11

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

To investigate the dynamics of body mass index (BMI) and height changes in childhood leading to obesity in adolescents. BMI Z-scores were calculated using the LMS (lambda-mu-sigma) method based on yearly height and weight information (age 1.5-15 years) from a nationwide Japanese birth cohort that started in 2001 (n = 26,711). We delineated the trajectories of BMI and height changes leading to obesity at age 15 years using mixed effect models. Children who became obese at the age of 15 years kept relatively high BMI z-scores through childhood for both genders, and had an increasing trend over time as opposed to the normal weight group, with an increasing slope during puberty. Early adiposity rebound was associated with overweight or obesity at the age of 15 years. Age at peak height velocity (APHV) occurred earlier in the obese/overweight group at age 15 years than in the normal weight group, and occurred later in the underweight group. Obese adolescents experienced early adiposity rebound timing and maintained a serial BMI z-score increase throughout childhood, with a greater slope at puberty. An earlier peak in height gain during puberty may have contributed to the observed patterns of BMI change.

DOI： 10.1038/s41598-021-02464-z

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Current Insights into Atopic March. Reviewed International journal

Mitsuru Tsuge, Masanori Ikeda, Naomi Matsumoto, Takashi Yorifuji, Hirokazu Tsukahara

Children (Basel, Switzerland) 8 ( 11 ) 1067 - 1067 2021.11

Language：English Publishing type：Research paper (scientific journal)

The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as "atopic march". Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset.

DOI： 10.3390/children8111067

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Association between Dental Caries and Influenza Infection in Children: A Japanese Nationwide Population-Based Study. Reviewed

Matsumoto N, Kadowaki T, Tsukahara H, Yorifuji T

Children (Basel). 8 ( 9 ) 780 - 780 2021.9

Short or Irregular Sleep Duration in Early Childhood Increases Risk of Injury for Primary School-Age Children: A Nationwide Longitudinal Birth Cohort in Japan. Reviewed

Obara T, Naito H, Tsukahara K, Matsumoto N, Yamamoto H, Yorifuji T, Nakao A

Int J Environ Res Public Health. 18 ( 18 ) 9512 - 9512 2021.9

Emergency dispatches for suicide attempts during the COVID-19 outbreak in Okayama, Japan: A descriptive epidemiological study Reviewed

Habu H, Takao S, Fujimoto R, Naito H, Nakao A, Yorifuji T

J Epidemiol. 31 ( 9 ) 511 - 517 2021.9

Association between Emergency Medical Services Transport Time and Survival in Patients with Traumatic Cardiac Arrest: A Nationwide Retrospective Observational Study Reviewed

Naito H, Yumoto T, Yorifuji T, Nojima T, Yamamoto H, Yamada T, Tsukahara K, Inaba M, Nishimura T, Uehara T, Nakao A

BMC Emerg Med. 21 ( 1 ) 104 - 104 2021.9

Early childhood exposure to maternal smoking and behavioral development. Reviewed International journal

Makiko Ariyoshi, Toshiharu Mitsuhashi, Naomi Matsumoto, Kazue Nakamura, Takashi Yorifuji

Archives of environmental & occupational health 77 ( 7 ) 568 - 575 2021.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

We examined the association between early childhood exposure to maternal smoking and behavioral issues at 8 years old using a large nationwide population-based longitudinal survey in Japan that began in 2001. We included 46,737 children with information about maternal smoking taken from the 6-month survey. We used logistic regression analysis to examine the hypothesis. Early childhood exposure to maternal smoking increased the risk of behavioral problems related to attention and aggressive or disruptive behavior. The adjusted odds ratios (95% confidence intervals) were 1.37 (1.22-1.54) for inability to wait their turn during play and 1.40 (1.27-1.55) for destroying toys and, compared with children of nonsmoking mothers. Children of mothers who were heavy smokers were more likely to develop behavioral problems than others. Stopping early childhood exposure to maternal exposure can protect children's neurodevelopment.

DOI： 10.1080/19338244.2021.1972278

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Effect of Patient Clinical Variables in Osteoporosis Classification Using Hip X-rays in Deep Learning Analysis. Reviewed

Yamamoto N, Sukegawa S, Yamashita K, Manabe M, Nakano K, Takabatake K, Kawai H, Ozaki T, Kawasaki K, Nagatsuka H, Furuki Y, Yorifuji T

Medicina (Kaunas). 57 ( 8 ) 846 - 846 2021.8

Television-watching in the early years of life and the association with parents' concerns about decreased visual acuity in their elementary school-aged child: results of a nationwide population-based longitudinal survey of Japan Reviewed

Matsuo T, Yorifuji T

Jpn J Ophthalmol. 65 ( 4 ) 561 - 568 2021.7

Excess all-cause mortality during the COVID-19 outbreak in Japan. Reviewed

Yorifuji T, Matsumoto N, Takao S

J Epidemiol. 31 ( 1 ) 90 - 92 2021.1

Environmental factors associated with expression of symptoms in children with autism Reviewed

Yoko Kado, Shigeru Oono, Takashi Yorifuji, Aki Mizumoto, Satoshi Sanada

HNUE Journal of Science, Educational Science 66 ( 4AB ) 3 - 10 2021

Intubation during a medevac flight: safety and effect on total prehospital time in the helicopter emergency medical service system Reviewed

Hiroki Maeyama, Hiromichi Naito, Francis X. Guyette, Takashi Yorifuji, Yuki Banshotani, Daisaku Matsui, Tetsuya Yumoto, Atsunori Nakao, Makoto Kobayashi

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 28 ( 1 ) 89 2020.12

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

<title>Abstract</title>
<sec>
<title>Introduction</title>
The Helicopter Emergency Medical Service (HEMS) commonly intubates patients who require advanced airway support prior to takeoff. In-flight intubation (IFI) is avoided because it is considered difficult due to limited space, difficulty communicating, and vibration in flight. However, IFI may shorten the total prehospital time. We tested whether IFI can be performed safely by the HEMS.

</sec>
<sec>
<title>Methods</title>
We conducted a retrospective cohort study in adult patients transported from 2010 to 2017 who received prehospital, non-emergent intubation from a single HEMS. We divided the cohort in two groups, patients intubated during flight (flight group, FG) and patients intubated before takeoff (ground group, GG). The primary outcome was the proportion of successful intubations. Secondary outcomes included total prehospital time and the incidence of complications.

</sec>
<sec>
<title>Results</title>
We analyzed 376 patients transported during the study period, 192 patients in the FG and 184 patients in the GG. The intubation success rate did not differ between the two groups (FG 189/192 [98.4%] vs. GG 179/184 [97.3%], <italic>p</italic> = 0.50). There were also no differences in hypoxia (FG 4/117 [3.4%] vs. GG 4/95 [4.2%], <italic>p</italic> = 1.00) or hypotension (FG 6/117 [5.1%] vs. GG 5/95 [5.3%], <italic>p</italic> = 1.00) between the two groups. Scene time and total prehospital time were shorter in the FG (scene time 7 min vs. 14 min, <italic>p</italic> < 0.001; total prehospital time 33.5 min vs. 40.0 min, <italic>p</italic> < 0.001).

</sec>
<sec>
<title>Conclusions</title>
IFI was safely performed with high success rates, similar to intubation on the ground, without increasing the risk of hypoxia or hypotension. IFI by experienced providers shortened transportation time, which may improve patient outcomes.

</sec>

DOI： 10.1186/s13049-020-00784-z

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Other Link： http://link.springer.com/article/10.1186/s13049-020-00784-z/fulltext.html

Antenatal Care Visits and Adverse Pregnancy Outcomes at a Hospital in Rural Western Province, Rwanda Reviewed

Akintije CS, Yorifuji T, Wada T, Mukakarake MG, Mutesa L, Yamamoto T

Acta Med Okayama. 74 ( 6 ) 495 - 503 2020.12

Delay in Emergency Medical Service Transportation Responsiveness during the COVID-19 Pandemic in a Minimally Affected Region Reviewed

Ageta K, Naito H, Yorifuji T, Obara T, Nojima T, Yamada T, Tsukahara K, Yakushiji H, Nakao A

Acta Med Okayama. 74 ( 6 ) 513 - 520 2020.12

Clinical Factors Affecting the Dose Conversion Ratio from Intravenous to Oral Tacrolimus Formulation among Pediatric Hematopoietic Stem Cell Transplantation Recipients Reviewed

Kanamitsu K, Yorifuji T, Ishida H, Fujiwara K, Washio K, Shimada A, Tsukahara H

Ther Drug Monit. 42 ( 6 ) 803 - 810 2020.12

Associations of Birth Weight for Gestational Age with Child Health and Neurodevelopment among Term Infants: A Nationwide Japanese Population-Based Study Reviewed

Kei Tamai, Takashi Yorifuji, Akihito Takeuchi, Yu Fukushima, Makoto Nakamura, Naomi Matsumoto, Yosuke Washio, Misao Kageyama, Hirokazu Tsukahara

The Journal of Pediatrics 226 135 - 141.e4 2020.11

Long-term exposure to nitrogen dioxide and natural-cause and cause-specific mortality in Japan Reviewed

Takashi Yorifuji, Saori Kashima

Science of The Total Environment 741 140465 - 140465 2020.11

Feasibility study of a portable transparent vinyl chloride shield for use in an ambulance during the COVID-19 pandemic Reviewed

Tsukahara K, Naito H, Nojima T, Yorifuji T, Nakao A

Crit Care. 24 ( 1 ) 651 - 651 2020.11

Continuing surgical education of non-technical skills Reviewed

Masaomi Yamane, Seiichiro Sugimoto, Etsuji Suzuki, Keiju Aokage, Mikio Okazaki, Junichi Soh, Makio Hayama, Yuji Hirami, Takashi Yorifuji, Shinichi Toyooka

Annals of Medicine and Surgery 58 177 - 186 2020.10

Exclusively Breastfeeding Modifies the Adverse Association of Late Preterm Birth and Gastrointestinal Infection: A Nationwide Birth Cohort Study Reviewed

Kazue Nakamura, Naomi Matsumoto, Makoto Nakamura, Akihito Takeuchi, Misao Kageyama, Takashi Yorifuji

Breastfeeding Medicine 15 ( 8 ) 509 - 515 2020.8

Comparison of Two Different Intensive Care Unit Systems for Severely Ill Children in Japan: Data from the JaRPAC Registry. Reviewed

Kohei Tsukahara, Hiromichi Naitou, Takashi Yorifuji, Nobuyuki Nosaka, Hirotsugu Yamamoto, Takaaki Osako, Atsunori Nakao

Acta medica Okayama 74 ( 4 ) 285 - 291 2020.8

Language：English Publishing type：Research paper (scientific journal)

The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted.

DOI： 10.18926/AMO/60365

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Improved outcomes for out-of-hospital cardiac arrest patients treated by emergency life-saving technicians compared with basic emergency medical technicians: A JCS-ReSS study report Reviewed

Hiromichi Naito, Tetsuya Yumoto, Takashi Yorifuji, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui

Resuscitation 153 251 - 257 2020.8

Exposure to particulate matter (PM2.5) and prevalence of diabetes mellitus in Indonesia Reviewed

Made Ayu Hitapretiwi Suryadhi, Putu Ayu Rhamani Suryadhi, Kawuli Abudureyimu, I Made Winarsa Ruma, Akintije Simba Calliope, Dewa Nyoman Wirawan, Takashi Yorifuji

Environment International 140 105603 - 105603 2020.7

A Simple Prognostic Benefit Scoring System for Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score Reviewed

Yamamoto H, Yamamoto H, Soh J, Suzuki E, Namba K, Suzawa K, Miyoshi K, Otani S, Okazaki M, Sugimoto S, Yamane M, Yorifuji T, Takahashi K, Toyooka S

Ann Surg Oncol. 28 ( 7 ) 3884 - 3890 2020.7

Geographical Differences and the National Meeting Effect in Patients with Out-of-Hospital Cardiac Arrests: A JCS–ReSS Study Report Reviewed

Tetsuya Yumoto, Hiromichi Naito, Takashi Yorifuji, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui

International Journal of Environmental Research and Public Health 16 ( 24 ) 5130 - 5130 2019.12

Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The “national meeting effect” refers to worse patient outcomes when medical professionals attend academic meetings and hospitals have reduced staffing. The aim of this study was to examine differences in outcomes of patients with out-of-hospital cardiac arrest (OHCA) admitted during, before, and after meeting days according to meeting location and considering regional variation of outcomes, which has not been investigated in previous studies. Using data from a nationwide, prospective, population-based, observational study in Japan, we analyzed adult OHCA patients who underwent resuscitation attempts between 2011 and 2015. Favorable one-month neurological outcomes were compared among patients admitted during the relevant annual meeting dates of three national scientific societies, those admitted on identical days the week before, and those one week after the meeting dates. We developed a multivariate logistic regression model after adjusting for confounding factors, including meeting location and regional variation (better vs. worse outcome areas), using the “during meeting days” group as the reference. A total of 40,849 patients were included in the study, with 14,490, 13,518, and 12,841 patients hospitalized during, before, and after meeting days, respectively. The rates of favorable neurological outcomes during, before, and after meeting days was 1.7, 1.6, and 1.8%, respectively. After adjusting for covariates, favorable neurological outcomes did not differ among the three groups (adjusted OR (95% CI) of the before and after meeting dates groups was 1.03 (0.83–1.28) and 1.01 (0.81–1.26), respectively. The “national meeting effect” did not exist in OHCA patients in Japan, even after comparing data during, before, and after meeting dates and considering meeting location and regional variation.

DOI： 10.3390/ijerph16245130

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Association of Japan Coma Scale score on hospital arrival with in-hospital mortality among trauma patients. Reviewed

Yumoto T, Naito H, Yorifuji T, Aokage T, Fujisaki N, Nakao A

BMC emergency medicine 19 ( 1 ) 65 2019.11

Lessons from an early-stage epidemiological study on Minamata disease. Reviewed

Yorifuji T

Journal of epidemiology 30 ( 1 ) 12 - 14 2019.11

Breastfeeding and risk of food allergy: A nationwide birth cohort in Japan. Reviewed

Matsumoto N, Yorifuji T, Nakamura K, Ikeda M, Tsukahara H, Doi H

Allergology international : official journal of the Japanese Society of Allergology 69 ( 1 ) 91 - 97 2019.9

Nitrogen dioxide and acute respiratory tract infections in children in Indonesia. Reviewed

Suryadhi MAH, Abudureyimu K, Kashima S, Yorifuji T

Archives of environmental & occupational health 75 ( 5 ) 274 - 280 2019.6

Long-term exposure to fine particulate matter and natural-cause and cause-specific mortality in Japan Reviewed

Takashi Yorifuji, Saori Kashima, Yasunari Tani, Junji Yamakawa, Hiroyuki Doi

Environmental Epidemiology 3 ( 3 ) e051 - e051 2019.6

Catch-up growth and behavioral development among preterm, small-for-gestational-age children: A nationwide Japanese population-based study. Reviewed International journal

Akihito Takeuchi, Takashi Yorifuji, Mariko Hattori, Kei Tamai, Kazue Nakamura, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Tatsuya Ogino, Katsuhiro Kobayashi, Hiroyuki Doi

Brain & development 41 ( 5 ) 397 - 405 2019.5

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine the relationship between the catch-up growth of preterm, SGA children and their behavioral development. METHODS: We analyzed data from a large Japanese, nationwide, population-based, longitudinal survey that started in 2001. We restricted the study participants to preterm children with information on height at 2 years of age (n = 1667). Catch-up growth for SGA infants was defined as achieving a height at 2 years of age above -2.0 standard deviations for chronological age. We then used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations of SGA/catch-up status with neurobehavioral development both at 5.5 and 8 years of age, adjusting for potential infant- and parent-related confounding factors. RESULTS: Twenty-six percent of preterm SGA infants failed to catch up. SGA children without catch-up growth were more likely to be unable to listen without fidgeting (OR 2.51, 95% CI: 1.06-5.93) and unable to focus on one task (OR 2.66, 95% CI: 1.09-6.48) compared with non-SGA children at 5.5 years of age. Furthermore, SGA children without catch-up growth were at significant risk for inattention at 8 years of age. CONCLUSIONS: SGA infants with poor postnatal growth were at risk for attention problems throughout preschool-age to school-age among preterm infants. Early detection and intervention for attention problems among these infants is warranted.

DOI： 10.1016/j.braindev.2018.12.004

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Correction: Takaoka, S., et al. Survey of the Extent of the Persisting Effects of Methylmercury Pollution on the Inhabitants around the Shiranui Sea, Japan. Toxics 2018, 6, 39. Reviewed

Takaoka S, Fujino T, Kawakami Y, Shigeoka SI, Yorifuji T

Toxics 7 ( 2 ) 22 2019.4

Effects of Household Air Pollution From Solid Fuel Use and Environmental Tobacco Smoke on Child Health Outcomes in Indonesia. Reviewed

Suryadhi MAH, Abudureyimu K, Kashima S, Yorifuji T

Journal of occupational and environmental medicine 61 ( 4 ) 335 - 339 2019.4

Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit. Reviewed

Atsuyoshi Iida, Hiromichi Naito, Takashi Yorifuji, Yoshito Zamami, Akane Yamada, Tadashi Koga, Toru Imai, Toshiaki Sendo, Atsunori Nakao, Shingo Ichiba

Acta medica Okayama 73 ( 2 ) 101 - 107 2019.4

Language：English

Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.

DOI： 10.18926/AMO/56645

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Long-term Trends in Prevalence of Neural Tube Defects in Japan. Reviewed

Yorifuji T

Journal of epidemiology 29 ( 4 ) 123 - 124 2019.4

Population-based longitudinal study showed that children born small for gestational age faced a higher risk of hospitalisation during early childhood. Reviewed

Yoshimoto J, Yorifuji T, Washio Y, Okamura T, Watanabe H, Doi H, Tsukahara H

Acta paediatrica (Oslo, Norway : 1992) 108 ( 3 ) 473 - 478 2019.3

Early childhood exposure to maternal smoking and Kawasaki Disease: A longitudinal survey in Japan. Reviewed

Yorifuji T, Tsukahara H, Doi H

The Science of the total environment 655 141 - 146 2019.3

Associations of gestational age with child health and neurodevelopment among twins: A nationwide Japanese population-based study. Reviewed International journal

Kei Tamai, Takashi Yorifuji, Akihito Takeuchi, Makoto Nakamura, Yosuke Washio, Hirokazu Tsukahara, Hiroyuki Doi, Misao Kageyama

Early human development 128 41 - 47 2019.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The prevalence of multiple births has recently increased. However, the association between gestational age and long-term morbidity among twins remains unclear. AIMS: To examine the association of gestational age with child health and neurological development in early childhood among twins. STUDY DESIGN: Population-based longitudinal study. SUBJECTS: We included 947 children from 479 pairs of twins with information on gestational age. OUTCOME MEASURES: Hospitalization was used as an indicator of physical health, and responses to questions about age-appropriate behaviors were used as an indicator of neurobehavioral development. We conducted binomial log-linear regression analyses, controlling for both child and maternal variables in the model. We accounted for correlations within the pairs with generalized estimating equations. RESULTS: The early term group (i.e., 37 to 38 weeks of gestation) had a lower risk of poor child health and unfavorable neurodevelopment compared with the full term group (≥39 weeks of gestation) and preterm group (<37 weeks of gestation). Compared with the early term group, the adjusted risk ratios for hospitalization for all causes during the period from 7 to 18 months of age was 2.2 (95% confidence interval: 1.3-3.8) for very preterm children (<32 weeks of gestation), 1.1 (0.8-1.6) for moderately and late preterm children (32 to 36 weeks of gestation), and 1.8 (1.0-3.2) for full term children. CONCLUSION: We observed a U-shaped association of gestational age with child health and neurodevelopment. The early term group had the lowest risk of poor outcomes among twins.

DOI： 10.1016/j.earlhumdev.2018.11.005

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Long-stay pediatric patients in Japanese intensive care units: their significant presence and a newly developed, simple predictive score. Reviewed

Knaup E, Nosaka N, Yorifuji T, Tsukahara K, Naito H, Tsukahara H, Nakao A, JaRPAC Study Group

Journal of intensive care 7 38 2019

Mortality in trauma patients admitted during, before, and after national academic emergency medicine and trauma surgery meeting dates in Japan. Reviewed

Yumoto T, Naito H, Ihoriya H, Yorifuji T, Nakao A

PloS one 14 ( 1 ) e0207049 2019

Acute exposure to sulfur dioxide and mortality: Historical data from Yokkaichi, Japan. Reviewed

Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K

Archives of environmental & occupational health 74 ( 5 ) 271 - 278 2019

Air quality management policy and reduced mortality rates in Seoul Metropolitan Area: A quasi-experimental study Reviewed

Changwoo Han, Youn-Hee Lim, Takashi Yorifuji, Yun-Chul Hong

Environment International 121 600 - 609 2018.12

Association of early daycare attendance with allergic disorders in children: a longitudinal national survey in Japan. Reviewed

Tokinobu A, Yorifuji T, Yamakawa M, Tsuda T, Doi H

Archives of environmental & occupational health 75 ( 1 ) 18 - 26 2018.12

Life Satisfaction, Interpersonal Relationships, and Learning Influence Withdrawal from School: A Study among Junior High School Students in Japan Reviewed

Sachiko Inoue, Tsuguhiko Kato, Takashi Yorifuji

International Journal of Environmental Research and Public Health 15 ( 10 ) 2309 - 2309 2018.10

Authorship：Last author Publishing type：Research paper (scientific journal) Publisher：MDPI AG

School absenteeism, particularly among junior high school students, has increased annually in Japan. This study demonstrates the relationship between subjective adjustment to school life and students’ absenteeism. Data were collected from 17,378 junior high school students in Japan. A longitudinal design was used for the study. Teachers were asked to distribute the Adaptation Scale for School Environments on Six Spheres (ASSESS) questionnaire to junior high school students and ask the students to fill out the questionnaire at the beginning of the 2014 academic year in April 2014, and the relationship between their subjective adjustment and absenteeism as measured by the total number of absent days during the 2014 academic year was evaluated by logistic regression and a survival analysis model. Low life satisfaction was associated with absences. The corresponding odds ratio (OR) was higher for seventh graders (OR 3.29, confidence interval (CI): 2.41–4.48, hazard ratio (HR) 5.57, CI: 3.51–8.84) than for students in other grades. Interpersonal relationships were significantly related to absenteeism for seventh and eighth graders in the group with scores less than 39 points. Lower adjustment to learning seemed to be related to absenteeism for seventh and eighth graders. For effective interventions, a well-designed study that uses detailed information regarding life-related covariates is necessary.

DOI： 10.3390/ijerph15102309

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Intelligence test at preschool-age predicts reading difficulty among school-aged very low birth weight infants in Japan. Reviewed International journal

Akihito Takeuchi, Tatsuya Ogino, Tatsuya Koeda, Makio Oka, Takashi Yorifuji, Toshimitsu Takayanagi, Kazuo Sato, Noriko Sugino, Motoki Bonno, Makoto Nakamura, Misao Kageyama

Brain & development 40 ( 9 ) 735 - 742 2018.10

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To elucidate whether the results of an intelligence test at preschool age are predictive of reading difficulty (RD) at school age among very low birth weight infants (VLBWI). METHODS: Subjects were 48 Japanese children whose birth weight was <1500 g and who regularly visited a follow-up clinic. All subjects completed the Wechsler Intelligence Scale for Children-III (WISC-III) during the last grade of kindergarten, and four reading tasks during the second to fourth grade of elementary school. All participants had a full-scale intelligence quotient score of 85 or higher. Subjects with a standard deviation reading time score greater than 2.0 in two or more tasks were considered to have RD. We evaluated the associations between each WISC-III score and RD using logistic regression analyses. Furthermore, we performed receiver operating characteristic (ROC) analysis to determine a cutoff WISC-III score predictive of RD. RESULTS: In the mutually-adjusted model, the adjusted odds ratio per 1 score increase of freedom from distractibility (FD) was 0.832 (95% confidence interval: 0.720-0.962). In the ROC analysis, an FD score of <95.5 was chosen as the cutoff value for predicting RD (sensitivity, 0.77; specificity, 0.74). CONCLUSION: The present study indicated that a lower FD score at preschool age, which was associated with deficits in verbal working memory and attention, is a risk factor for RD at school age among Japanese VLBWI. Further investigation is desired to clarify the cognitive deficits underlying RD in Japanese-speaking preterm children, and to establish appropriate interventions for these children.

DOI： 10.1016/j.braindev.2018.05.002

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Disease and injury trends among evacuees in a shelter located at the epicenter of the 2016 Kumamoto earthquakes, Japan Reviewed

Takashi Yorifuji, Takushi Sato, Toru Yoneda, Yoshiomi Kishida, Sumie Yamamoto, Taro Sakai, Hiroshi Sashiyama, Shuko Takahashi, Hayato Orui, Daisuke Kato, Taro Hasegawa, Yoshihiro Suzuki, Maki Okamoto, Hideki Hayashi, Shigeru Suganami

Archives of Environmental & Occupational Health 73 ( 5 ) 284 - 291 2018.9

Accelerated functional losses in ageing congenital Minamata disease patients Reviewed

Takashi Yorifuji, Shigeru Takaoka, Philippe Grandjean

Neurotoxicology and Teratology 69 49 - 53 2018.9

Comparison of land use regression models for NO2 based on routine and campaign monitoring data from an urban area of Japan Reviewed

Saori Kashima, Takashi Yorifuji, Norie Sawada, Tomoki Nakaya, Akira Eboshida

Science of The Total Environment 631-632 1029 - 1037 2018.8

Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan. Reviewed

Goto S, Nosaka N, Yorifuji T, Wada T, Fujii Y, Yashiro M, Washio Y, Hasegawa K, Tsukahara H, Morishima T

Acta medica Okayama 72 ( 4 ) 351 - 357 2018.8

National data showed that delayed sleep in six-year-old children was associated with excessive use of electronic devices at 12 years Reviewed

Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue

Acta Paediatrica 107 ( 8 ) 1439 - 1448 2018.8

Survey of the Extent of the Persisting Effects of Methylmercury Pollution on the Inhabitants around the Shiranui Sea, Japan Reviewed

Shigeru Takaoka, Tadashi Fujino, Yoshinobu Kawakami, Shin-ichi Shigeoka, Takashi Yorifuji

Toxics 6 ( 3 ) 39 - 39 2018.7

Authorship：Last author Publishing type：Research paper (scientific journal) Publisher：MDPI AG

In 1956 methylmercury poisoning, known as Minamata disease, was discovered among the inhabitants around the Shiranui Sea, Kyushu, Japan. Although about five hundred thousand people living in the area had supposedly been exposed to methylmercury, administrative agencies and research institutes had not performed any subsequent large scale, continuous health examination, so the actual extent of the negative health effects was not clearly documented. In 2009, we performed health surveys in order to examine residents in the polluted area and to research the extent of the polluted area and period of pollution. We analyzed data collected on 973 people (age = 62.3 ± 11.7) who had lived in the polluted area and had eaten the fish there and a control group, consisting of 142 persons (age = 62.0 ± 10.5), most of whom had not lived in the polluted area. Symptoms and neurological signs were statistically more prevalent in the four groups than in the control group and were more prevalent and severe in those who had eaten most fish. The patterns of positive findings of symptoms and neurological findings in the four groups were similar. Our data indicates that Minamata disease had spread outside of the central area and could still be observed recently, almost 50 years after the Chisso Company’s factory had halted the dumping of mercury polluted waste water back in 1968.

DOI： 10.3390/toxics6030039

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Self-rated School Adjustment and Absenteeism: An Epidemiological Study Reviewed

Sachiko Inoue, Tsuguhiko Kato, Takashi Yorifuji

Health Behavior and Policy Review 5 ( 3 ) 59 - 66 2018.5

Birth order and paediatric allergic disease: A nationwide longitudinal survey Reviewed

T. Kikkawa, T. Yorifuji, Y. Fujii, M. Yashiro, A. Okada, M. Ikeda, H. Doi, H. Tsukahara

Clinical & Experimental Allergy 48 ( 5 ) 577 - 585 2018.5

Maternal smoking as a risk factor for childhood intussusception Reviewed

Yasuo Nakahara, Takashi Yorifuji, Toshihide Kubo, Hiroyuki Doi

Archives of Environmental & Occupational Health 73 ( 2 ) 96 - 101 2018.3

Cushing’s sign and severe traumatic brain injury in children after blunt trauma: a nationwide retrospective cohort study in Japan Reviewed

Tetsuya Yumoto, Hiromichi Naito, Takashi Yorifuji, Hiroki Maeyama, Yoshinori Kosaki, Hirotsugu Yamamoto, Kohei Tsukahara, Takaaki Osako, Atsunori Nakao

BMJ Open 8 ( 3 ) e020781 - e020781 2018.3

Publishing type：Research paper (scientific journal) Publisher：BMJ

<sec><title>Objective</title>We tested whether Cushing’s sign could predict severe traumatic brain injury (TBI) requiring immediate neurosurgical intervention (BI-NSI) in children after blunt trauma.

</sec><sec><title>Design</title>Retrospective cohort study using Japan Trauma Data Bank.

</sec><sec><title>Setting</title>Emergency and critical care centres in secondary and tertiary hospitals in Japan.

</sec><sec><title>Participants</title>Children between the ages of 2 and 15 years with Glasgow Coma Scale motor scores of 5 or less at presentation after blunt trauma from 2004 to 2015 were included. A total of 1480 paediatric patients were analysed.

</sec><sec><title>Primary outcome measures</title>Patients requiring neurosurgical intervention within 24 hours of hospital arrival and patients who died due to isolated severe TBI were defined as BI-NSI. The combination of systolic blood pressure (SBP) and heart rate (HR) on arrival, which were respectively divided into tertiles, and its correlation with BI-NSI were investigated using a multiple logistic regression model.

</sec><sec><title>Results</title>In the study cohort, 297 (20.1%) exhibited BI-NSI. After adjusting for sex, age category and with or without haemorrhage shock, groups with higher SBP and lower HR (SBP ≥135 mm Hg; HR ≤92 bpm) were significantly associated with BI-NSI (OR 2.84, 95% CI 1.68 to 4.80, P<0.001) compared with the patients with normal vital signs. In age-specific analysis, hypertension and bradycardia were significantly associated with BI-NSI in a group of 7–10 and 11–15 years of age; however, no significant association was observed in a group of 2–6 years of age.

</sec><sec><title>Conclusions</title>Cushing’s sign after blunt trauma was significantly associated with BI-NSI in school-age children and young adolescents.

</sec>

DOI： 10.1136/bmjopen-2017-020781

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Intrauterine and Early Postnatal Exposure to Particulate Air Pollution and Kawasaki Disease: A Nationwide Longitudinal Survey in Japan Reviewed

Takashi Yorifuji, Hirokazu Tsukahara, Saori Kashima, Hiroyuki Doi

The Journal of Pediatrics 193 147 - 154 2018.2

Effects of tongue cleaning on Ayurvedic digestive power and oral health-related quality of life: A randomized cross-over study Reviewed

A. Tokinobu, T. Yorifuji, M. Sasai, H. Doi, T. Tsuda

Complementary Therapies in Medicine 36 9 - 13 2018.2

Catch-Up Growth and Neurobehavioral Development among Full-Term, Small-for-Gestational-Age Children: A Nationwide Japanese Population-Based Study Reviewed

Akihito Takeuchi, Takashi Yorifuji, Kazue Nakamura, Kei Tamai, Shigehiro Mori, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Tatsuya Ogino, Katsuhiro Kobayashi, Hiroyuki Doi

The Journal of Pediatrics 192 41 - 46 2018.1

Temporal trends of infant and birth outcomes in Minamata after severe methylmercury exposure Reviewed

Takashi Yorifuji, Saori Kashima, Made Ayu Hitapretiwi Suryadhi, Kawuli Abudureyimu

Environmental Pollution 231 1586 - 1592 2017.12

Are People With a History of Disease More Susceptible to a Short-term Exposure to Asian Dust? Reviewed

Saori Kashima, Takashi Yorifuji, Etsuji Suzuki

Epidemiology 28 S60 - S66 2017.10

Impact of maternal and paternal smoking on birth outcomes Reviewed

Sachiko Inoue, Hiroo Naruse, Takashi Yorifuji, Tsuguhiko Kato, Takeshi Murakoshi, Hiroyuki Doi, S.V. Subramanian

Journal of Public Health 39 ( 3 ) 557 - 566 2017.9

Is there an obesity paradox in the Japanese elderly population? A community-based cohort study of 13 280 men and women Reviewed

Kenji Yamazaki, Etsuji Suzuki, Takashi Yorifuji, Toshihide Tsuda, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

GERIATRICS & GERONTOLOGY INTERNATIONAL 17 ( 9 ) 1257 - 1264 2017.9

New age-based weight estimation formulae for Japanese children Reviewed

Nobuyuki Nosaka, Takashi Yorifuji, Emily Knaup, Kohei Tsukahara, Takashi Muguruma, Ayumi Okada, Hirokazu Tsukahara, Hiroyuki Doi

Pediatrics International 59 ( 6 ) 727 - 732 2017.6

Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder Reviewed

Takashi Yorifuji, Kenichi Matsuoka, Philippe Grandjean

Environmental Research 155 86 - 91 2017.5

Association of maternal age with child health: A Japanese longitudinal study Reviewed

Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue, Hiroyuki Doi, Akira Eboshida, Ichiro Kawachi

PLOS ONE 12 ( 2 ) e0172544 - e0172544 2017.2

Prenatal exposure to outdoor air pollution and child behavioral problems at school age in Japan Reviewed

Takashi Yorifuji, Saori Kashima, Midory Higa Diez, Yoko Kado, Satoshi Sanada, Hiroyuki Doi

Environment International 99 192 - 198 2017.2

Behavioral outcomes of school-aged full-term small-for-gestational-age infants: A nationwide Japanese population-based study Reviewed

Akihito Takeuchi, Takashi Yorifuji, Kyohei Takahashi, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Tatsuya Ogino, Katsuhiro Kobayashi, Hiroyuki Doi

Brain and Development 39 ( 2 ) 101 - 106 2017.2

Maternal smoking location at home and hospitalization for respiratory tract infections among children in Japan Reviewed

Michiyo Yamakawa, Takashi Yorifuji, Tsuguhiko Kato, Toshihide Tsuda, Hiroyuki Doi

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 72 ( 6 ) 343 - 350 2017

Fine-particulate Air Pollution from Diesel Emission Control and Mortality Rates in Tokyo A Quasi-experimental Study Reviewed

Takashi Yorifuji, Saori Kashima, Hiroyuki Doi

EPIDEMIOLOGY 27 ( 6 ) 769 - 778 2016.11

Children's Media Use and Self-Regulation Behavior: Longitudinal Associations in a Nationwide Japanese Study Reviewed

Sachiko Inoue, Takashi Yorifuji, Tsuguhiko Kato, Satoshi Sanada, Hiroyuki Doi, Ichiro Kawachi

MATERNAL AND CHILD HEALTH JOURNAL 20 ( 10 ) 2084 - 2099 2016.10

Development of a Japanese scale for assessment of paediatric normal weight Reviewed

Nobuyuki Nosaka, Takashi Yorifuji, Emily Knaup, Takashi Muguruma, Ayumi Okada, Hirokazu Tsukahara, Hiroyuki Doi

RESUSCITATION 105 E12 2016.8

Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA) Reviewed

Christopher J. Portier, Bruce K. Armstrong, Bruce C. Baguley, Xaver Baur, Igor Belyaev, Robert Belle, Fiorella Belpoggi, Annibale Biggeri, Maarten C. Bosland, Paolo Bruzzi, Lygia Therese Budnik, Merete D. Bugge, Kathleen Burns, Gloria M. Calaf, David O. Carpenter, Hillary M. Carpenter, Lizbeth Lopez-Carrillo, Richard Clapp, Pierluigi Cocco, Dario Consonni, Pietro Comba, Elena Craft, Mohamed Aqiel Dalvie, Devra Davis, Paul A. Demers, Anneclaire J. De Roos, Jamie DeWitt, Francesco Forastiere, Jonathan H. Freedman, Lin Fritschi, Caroline Gaus, Julia M. Gohlke, Marcel Goldberg, Eberhard Greiser, Johnni Hansen, Lennart Hardell, Michael Hauptmann, Wei Huang, James Huff, Margaret O. James, C. W. Jameson, Andreas Kortenkamp, Annette Kopp-Schneider, Hans Kromhout, Marcelo L. Larramendy, Philip J. Landrigan, Lawrence H. Lash, Dariusz Leszczynski, Charles F. Lynch, Corrado Magnani, Daniele Mandrioli, Francis L. Martin, Enzo Merler, Paola Michelozzi, Lucia Miligi, Anthony B. Miller, Dario Mirabelli, Franklin E. Mirer, Saloshni Naidoo, Melissa J. Perry, Maria Grazia Petronio, Roberta Pirastu, Ralph J. Portier, Kenneth S. Ramos, Larry W. Robertson, Theresa Rodriguez, Martin Roosli, Matt K. Ross, Deodutta Roy, Ivan Rusyn, Paulo Saldiva, Jennifer Sass, Kai Savolainen, Paul T. J. Scheepers, Consolato Sergi, Ellen K. Silbergeld, Martyn T. Smith, Bernard W. Stewart, Patrice Sutton, Fabio Tateo, Benedetto Terracini, Heinz W. Thielmann, David B. Thomas, Harri Vainio, John E. Vena, Paolo Vineis, Elisabete Weiderpass, Dennis D. Weisenburger, Tracey J. Woodruff, Takashi Yorifuji, Il Je Yu, Paola Zambon, Hajo Zeeb, Shu-Feng Zhou

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH 70 ( 8 ) 741 - 745 2016.8

Breastfeeding and Risk of Kawasaki Disease: A Nationwide Longitudinal Survey in Japan Reviewed

Takashi Yorifuji, Hirokazu Tsukahara, Hiroyuki Doi

PEDIATRICS 137 ( 6 ) 2016.6

Neurodevelopment in full-term small for gestational age infants: A nationwide Japanese population-based study Reviewed

Akihito Takeuchi, Takashi Yorifuji, Kyohei Takahashi, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Tatsuya Ogino, Hiroyuki Doi

BRAIN & DEVELOPMENT 38 ( 6 ) 529 - 537 2016.6

Acute exposure to fine and coarse particulate matter and infant mortality in Tokyo, Japan (2002-2013) Reviewed

Takashi Yorifuji, Saori Kashima, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 551 66 - 72 2016.5

Secondary sex ratio in regions severely exposed to methylmercury "Minamata disease" Reviewed

Takashi Yorifuji, Saori Kashima

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 89 ( 4 ) 659 - 665 2016.5

Preterm birth and behavioural outcomes at 8 years of age: a nationwide survey in Japan Reviewed

Midory Higa Diez, Takashi Yorifuji, Yoko Kado, Satoshi Sanada, Hiroyuki Doi

ARCHIVES OF DISEASE IN CHILDHOOD 101 ( 4 ) 338 - 343 2016.4

Association between Short Maternal Height and Low Birth Weight: A Hospital-based Study in Japan Reviewed

Sachiko Inoue, Hiroo Naruse, Takashi Yorifuji, Tsuguhiko Kato, Takeshi Murakoshi, Hiroyuki Doi, S. V. Subramanian

JOURNAL OF KOREAN MEDICAL SCIENCE 31 ( 3 ) 353 - 359 2016.3

Asian dust effect on cause-specific mortality in five cities across South Korea and Japan Reviewed

Saori Kashima, Takashi Yorifuji, Sanghyuk Bae, Yasushi Honda, Youn-Hee Lim, Yun-Chul Hong

ATMOSPHERIC ENVIRONMENT 128 20 - 27 2016.3

Neurological and neuropsychological functions in adults with a history of developmental arsenic poisoning from contaminated milk powder Reviewed

Takashi Yorifuji, Tsuguhiko Kato, Hitoshi Ohta, David C. Bellinger, Kenichi Matsuoka, Philippe Grandjean

Neurotoxicology and Teratology 53 75 - 80 2016.1

Prenatal Exposure to Traffic-related Air Pollution and Child Behavioral Development Milestone Delays in Japan Reviewed

Takashi Yorifuji, Saori Kashima, Midory Higa Diez, Yoko Kado, Satoshi Sanada, Hiroyuki Doi

EPIDEMIOLOGY 27 ( 1 ) 57 - 65 2016.1

Effects of Ayurvedic Oil-Dripping Treatment with Sesame Oil vs. with Warm Water on Sleep: A Randomized Single-Blinded Crossover Pilot Study Reviewed

Akiko Tokinobu, Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE 22 ( 1 ) 52 - 58 2016.1

Associations of acute exposure to fine and coarse particulate matter and mortality among older people in Tokyo, Japan Reviewed

Takashi Yorifuji, Saori Kashima, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 542 354 - 359 2016.1

Neurological and neurocognitive functions from intrauterine methylmercury exposure Reviewed

Takashi Yorifuji, Yoko Kado, Midory Higa Diez, Toshihiro Kishikawa, Satoshi Sanada

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 ( 3 ) 170 - 177 2016

Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan Reviewed

Takashi Yorifuji, Toshihide Tsuda

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 ( 4 ) 231 - 236 2016

Intrauterine Exposure to Methylmercury and Neurocognitive Functions: Minamata Disease Reviewed

Takashi Yorifuji, Tsuguhiko Kato, Yoko Kado, Akiko Tokinobu, Michiyo Yamakawa, Toshihide Tsuda, Satoshi Sanada

Archives of Environmental & Occupational Health 70 ( 5 ) 297 - 302 2015.9

Long-Term Effects of Breastfeeding on Children's Hospitalization for Respiratory Tract Infections and Diarrhea in Early Childhood in Japan Reviewed

Michiyo Yamakawa, Takashi Yorifuji, Tsuguhiko Kato, Sachiko Inoue, Akiko Tokinobu, Toshihide Tsuda, Hiroyuki Doi

MATERNAL AND CHILD HEALTH JOURNAL 19 ( 9 ) 1956 - 1965 2015.9

Breast-feeding and hospitalization for asthma in early childhood: a nationwide longitudinal survey in Japan Reviewed

Michiyo Yamakawa, Takashi Yorifuji, Tsuguhiko Kato, Yoshitada Yamauchi, Hiroyuki Doi

PUBLIC HEALTH NUTRITION 18 ( 10 ) 1756 - 1761 2015.7

Health Impact Assessment of PM10 and PM2.5 in 27 Southeast and East Asian Cities Reviewed

Takashi Yorifuji, Sanghyuk Bae, Saori Kashima, Toshihide Tsuda, Hiroyuki Doi, Yasushi Honda, Ho Kim, Yun-Chul Hong

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 57 ( 7 ) 751 - 756 2015.7

Non-Linear Concentration-Response Relationships between Ambient Ozone and Daily Mortality Reviewed

Sanghyuk Bae, Youn-Hee Lim, Saori Kashima, Takashi Yorifuji, Yasushi Honda, Ho Kim, Yun-Chul Hong

PLOS ONE 10 ( 6 ) ee0129423 2015.6

Poor toddler-age sleep schedules predict school-age behavioral disorders in a longitudinal survey. Reviewed International journal

Katsuhiro Kobayashi, Takashi Yorifuji, Michiyo Yamakawa, Makio Oka, Sachiko Inoue, Harumi Yoshinaga, Hiroyuki Doi

Brain & development 37 ( 6 ) 572 - 578 2015.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Behavioral problems are often associated with poor sleep habits in children. We investigated whether undesirable toddler-age sleep schedules may be related to school-age behavioral problems. METHODS: We analyzed the data of a nationwide longitudinal survey with available results from 2001 to 2011. The participants were 41,890 children. The predictors were waking time and bedtime at 2years of age, and the outcomes were assessed by determining the presence or absence of three attention problems and four aggressiveness problems at 8years of age. In logistic regression models with adjustments for confounding factors, we estimated odds ratios (ORs) and confidence intervals (CIs) for the association between toddler sleep schedules and behavior during primary-school age years. RESULTS: The outcomes of attention problems and aggressiveness problems were observed in 1.7% and 1.2% of children, respectively, at 8years of age. The OR of an irregular or late morning waking time at 2years of age with the outcome of aggressiveness problems was 1.52 (95% CI, 1.04-2.22) in comparison to an early waking time. The OR of an irregular or late bedtime with attention problems was 1.62 (95% CI, 1.12-2.36), and the OR of an irregular or late bedtime with aggressiveness problems was 1.81 (95% CI, 1.19-2.77) in comparison to an early bedtime. CONCLUSION: Poor toddler-age sleep schedules were found to predict behavioral problems during primary-school age years. Thus, good and regular sleep habits appear to be important for young children's healthy development.

DOI： 10.1016/j.braindev.2014.10.004

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Cancer and non-cancer excess mortality resulting from mixed exposure to polychlorinated biphenyls and polychlorinated dibenzofurans from contaminated rice oil: "Yusho" Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda, Akira Eboshida

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 88 ( 4 ) 419 - 430 2015.5

Residential proximity to major roads and obstetrical complications Reviewed

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Takeshi Murakoshi, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 508 188 - 192 2015.3

Outdoor air pollution and term low birth weight in Japan Reviewed

Takashi Yorifuji, Saori Kashima, Hiroyuki Doi

ENVIRONMENT INTERNATIONAL 74 106 - 111 2015.1

Association of breast feeding with early childhood dental caries: Japanese population-based study Reviewed

Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue, Keiko Saito, Hiroyuki Doi, Ichiro Kawachi

BMJ OPEN 5 ( 3 ) e006982 2015

Asian dust and daily emergency ambulance calls among elderly people in Japan Reviewed

Saori Kashima, Takashi Yorifuji, Etsuji Suzuki

Journal of Occupational and Environmental Medicine 56 ( 12 ) 1277 - 1283 2014.12

Hourly differences in air pollution and risk of respiratory disease in the elderly: a time-stratified case-crossover study Reviewed

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Environmental Health 13 ( 1 ) 67 2014.12

Outdoor air pollution and out-of-hospital cardiac arrest in Okayama, Japan Reviewed

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Journal of Occupational and Environmental Medicine 56 ( 10 ) 1019 - 1023 2014.10

Breastfeeding and behavioral development: a nationwide longitudinal survey in Japan. Reviewed

Yorifuji T, Kubo T, Yamakawa M, Kato T, Inoue S, Tokinobu A, Doi H

J Pediatr. 164 ( 5 ) 1019 - 1025 2014.5

Correspondence to the Editor Re Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease Reviewed

Takashi Yorifuji, Saori Kashima, Eiji Yamamoto

ENVIRONMENT INTERNATIONAL 64 69 - 70 2014.3

Minamata Reviewed

T. Yorifuji, T. Tsuda

Encyclopedia of Toxicology: Third Edition 340 - 344 2014.1

Industrial distributions of severe occupational injuries among workers in Thailand. Reviewed International journal

Michiyo Yamakawa, Pornchai Sithisarankul, Takashi Yorifuji, Sarunya Hengpraprom, Narin Hiransuthikul, Hiroyuki Doi, Soshi Takao

Journal of occupational health 55 ( 5 ) 415 - 21 2014

Language：English

BACKGROUND: In industrializing countries, occupational safety and health have been affected by globalization. However, a lack of reliable data prevents evaluation of this situation. Therefore, we examined industrial distributions and risks of severe occupational injuries among workers in Thailand, which is one of the few industrializing countries that compiles nationwide data. METHODS: Data on workers who made claims for occupational injuries from 2007 to 2009 were extracted from the Workmen's Compensation Fund records in Thailand. Among 501,334 claimants, we evaluated the industrial distributions of severe occupational injuries (i.e., permanent disability and death). We then examined the associations between industry and those injuries, using proportionate ratios (PRs) between each industrial category and the overall distribution of occupational injuries. RESULTS: The number of workers in manufacturing making claims for severe occupational injuries was the largest among all industrial categories (319,114/501,334 injuries), although the total number of occupational injuries recently declined. Additionally, workers in manufacturing experienced severe occupational injuries more often compared with the overall distribution of occupational injuries. The PRs (95% confidence interval) for manufacturing were 1.17 (1.14-1.20) in men and 1.33 (1.27-1.38) in women. After adjusting for individual characteristics, the results did not substantially change. CONCLUSIONS: Manufacturing seems to have the largest burden of occupational injuries in industrializing countries like Thailand.

DOI： 10.1539/joh.13-0085-fs

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Cardiovascular emergency hospital visits and hourly changes in air pollution Reviewed

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Stroke 45 ( 5 ) 1264 - 1268 2014

Outdoor particulate matter exposure and lung cancer: A systematic review and meta-analysis Reviewed

Ghassan B. Hamra, Neela Guha, Aaron Cohen, Francine Laden, Ole Raaschou-Nielsen, Jonathan M. Samet, Paolo Vineis, Francesco Forastiere, Paulo Saldiva, Takashi Yorifuji, Dana Loomis

Environmental Health Perspectives 122 ( 9 ) 906 - 911 2014

Social Cohesion and Mortality: A Survival Analysis of Older Adults in Japan Reviewed

Sachiko Inoue, Takashi Yorifuji, Soshi Takao, Hiroyuki Doi, Ichiro Kawachi

AMERICAN JOURNAL OF PUBLIC HEALTH 103 ( 12 ) E60 - E66 2013.12

Who is at Risk of Inadequate Weight Gain During Pregnancy? Analysis by Occupational Status Among 15,020 Deliveries in a Regional Hospital in Japan Reviewed

Sachiko Inoue, Hiroo Naruse, Takashi Yorifuji, Takeshi Murakoshi, Hiroyuki Doi, Ichiro Kawachi

MATERNAL AND CHILD HEALTH JOURNAL 17 ( 10 ) 1888 - 1897 2013.12

The carcinogenicity of outdoor air pollution.

Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K, International Agency for, Research on Cancer Monograph Working, Group IARC

Lancet Oncol. 14 ( 13 ) 1262 - 1263 2013.12

Associations of Preterm Births with Child Health and Development: Japanese Population-Based Study Reviewed

Tsuguhiko Kato, Takashi Yorifuji, Sachiko Inoue, Michiyo Yamakawa, Hiroyuki Doi, Ichiro Kawachi

JOURNAL OF PEDIATRICS 163 ( 6 ) 1578 - U98 2013.12

Response to Fukuda et al.

R. Catalano, T. Yorifuji, I. Kawachi

American Journal of Human Biolog 25 ( 6 ) 860 - 860 2013.11

Breastfeeding and obesity among schoolchildren: a nationwide longitudinal survey in Japan. Reviewed International journal

Michiyo Yamakawa, Takashi Yorifuji, Sachiko Inoue, Tsuguhiko Kato, Hiroyuki Doi

JAMA pediatrics 167 ( 10 ) 919 - 25 2013.10

Language：English Publishing type：Research paper (scientific journal)

IMPORTANCE: Although it is suggested that breastfeeding is protective against obesity in children, the evidence remains inconclusive because of possible residual confounding by socioeconomic status or children's lifestyle factors. Most of the participants in the previous studies were children in Western developed countries, so studies in a different context are awaited. OBJECTIVE: To examine the associations of breastfeeding with overweight and obesity among schoolchildren in Japan, with adjustment for the potential confounders. DESIGN: Secondary data analyses of a nationwide longitudinal survey ongoing since 2001, with results collected from 2001 to 2009. SETTING: All over Japan. PARTICIPANTS: A total of 43,367 singleton children who were born after 37 gestational weeks and had information on their feeding during infancy. EXPOSURES: Five mutually exclusive infant feeding practice categories. MAIN OUTCOMES AND MEASURES: Underweight, normal weight (referent group), overweight, and obesity at 7 and 8 years of age defined by using international cutoff points of body mass index by sex and age. RESULTS: In multinomial logistic regression models with adjustment for children's factors (sex, television viewing time, and computer game playing time) and maternal factors (educational attainment, smoking status, and working status), exclusive breastfeeding at 6 to 7 months of age was associated with decreased risk of overweight and obesity compared with formula feeding. The adjusted odds ratios were 0.85 (95% CI, 0.69-1.05) and 0.55 (95% CI, 0.39-0.78) for overweight and obesity, respectively, at 7 years of age. Similar results were observed at 8 years of age. CONCLUSIONS AND RELEVANCE: Breastfeeding is associated with decreased risk of overweight and obesity among schoolchildren in Japan. Therefore, it would be better to encourage breastfeeding even in developed countries.

DOI： 10.1001/jamapediatrics.2013.2230

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Inhibitory Function and Working Memory in Attention Deficit/Hyperactivity Disorder and Pervasive Developmental Disorders: Does a Continuous Cognitive Gradient Explain ADHD and PDD Traits? Reviewed

Akihito Takeuchi, Tatsuya Ogino, Kaoru Hanafusa, Teruko Morooka, Makio Oka, Takashi Yorifuji, Yoko Ohtsuka

ACTA MEDICA OKAYAMA 67 ( 5 ) 293 - 303 2013.10

Regional impact of exposure to a polychlorinated biphenyl and polychlorinated dibenzofuran mixture from contaminated rice oil on stillbirth rate and secondary sex ratio Reviewed

Takashi Yorifuji, Saori Kashima, Akiko Tokinobu, Tsuguhiko Kato, Toshihide Tsuda

ENVIRONMENT INTERNATIONAL 59 12 - 15 2013.9

Air pollution: another cause of lung cancer Reviewed

Takashi Yorifuji, Saori Kashima

LANCET ONCOLOGY 14 ( 9 ) 788 - 789 2013.8

Visual evoked potentials in children prenatally exposed to methylmercury Reviewed

Takashi Yorifuji, Katsuyuki Murata, Kristian S. Bjerve, Anna L. Choi, Pal Weihe, Philippe Grandjean

NeuroToxicology 37 15 - 18 2013.7

Associations of Particulate Matter With Stroke Mortality A Multicity Study in Japan Reviewed

Takashi Yorifuji, Saori Kashima

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 55 ( 7 ) 768 - 771 2013.7

Association of Birth Length and Risk of Hospitalisation among Full-term Babies in Japan Reviewed

Tsuguhiko Kato, Takashi Yorifuji, Sachiko Inoue, Hiroyuki Doi, Ichiro Kawachi

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY 27 ( 4 ) 361 - 370 2013.7

Natural selection in utero: Evidence from the great east japan earthquake Reviewed

R. Catalano, T. Yorifuji, I. Kawachi

American Journal of Human Biology 25 ( 4 ) 555 - 559 2013.7

Contribution of smoking to the gender gap in life expectancy in Japan Reviewed

T. Yorifuji, S. Takao, S. Inoue, S. Tanihara, I. Kawachi

Public Health 127 ( 5 ) 482 - 484 2013.5

Residential proximity to major roads and adverse birth outcomes: a hospital-based study Reviewed

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Soshi Takao, Takeshi Murakoshi, Hiroyuki Doi, Ichiro Kawachi

ENVIRONMENTAL HEALTH 12 ( 1 ) 34 2013.4

Does Habitual Physical Activity Prevent Insomnia? A Cross-Sectional and Longitudinal Study of Elderly Japanese Reviewed

Sachiko Inoue, Takashi Yorifuji, Masumi Sugiyama, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

JOURNAL OF AGING AND PHYSICAL ACTIVITY 21 ( 2 ) 119 - 139 2013.4

Critical Appraisal of the 1977 Diagnostic Criteria for Minamata Disease Reviewed

Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada, Ichiro Kawachi

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 68 ( 1 ) 22 - 29 2013.1

Long-term exposure to traffic-related air pollution and the risk of death from hemorrhagic stroke and lung cancer in Shizuoka, Japan Reviewed

Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Kazuko Ishikawa-Takata, Toshiki Ohta, Ken-ichi Tsuruta, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 443 397 - 402 2013.1

Asian dust and daily all-cause or cause-specific mortality in western Japan Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda, Akira Eboshida

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 69 ( 12 ) 908 - 915 2012.12

Trends of preterm birth and low birth weight in Japan: a one hospital-based study Reviewed

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Takeshi Murakoshi, Tsuguhiko Kato, Sachiko Inoue, Hiroyuki Doi, Ichiro Kawachi

BMC PREGNANCY AND CHILDBIRTH 12 162 2012.12

Frequency of Antenatal Care Visits and Neonatal Mortality in Indonesia Reviewed

Juliani Ibrahim, Takashi Yorifuji, Toshihide Tsuda, Saori Kashima, Hiroyuki Doi

JOURNAL OF TROPICAL PEDIATRICS 58 ( 3 ) 184 - 188 2012.6

Does Open-air Exposure to Volatile Organic Compounds near a Plastic Recycling Factory Cause Health Effects? Reviewed

Takashi Yorifuji, Miyuki Noguchi, Toshihide Tsuda, Etsuji Suzuki, Soshi Takao, Saori Kashima, Yukio Yanagisawa

JOURNAL OF OCCUPATIONAL HEALTH 54 ( 2 ) 79 - 87 2012.3

Short-term effect of severe exposure to methylmercury on atherosclerotic heart disease and hypertension mortality in Minamata Reviewed

Sachiko Inoue, Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 417 291 - 293 2012.2

Epidemiological evidence on methylmercury neurotoxicity Reviewed

Jordi Julvez, Takashi Yorifuji, Anna L. Choi, Philippe Grandjean

Methylmercury and Neurotoxicity 13 - 35 2012.1

Residential proximity to major roads and placenta/birth weight ratio Reviewed

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Takeshi Murakoshi, Toshihide Tsuda, Hiroyuki Doi, Ichiro Kawachi

SCIENCE OF THE TOTAL ENVIRONMENT 414 98 - 102 2012.1

Evaluating the need for and effect of percutaneous transluminal angioplasty on arteriovenous fistulas by using total recirculation rate per dialysis session (o"Clearance Gapo") Reviewed

Toyomu Ugawa, Kazufumi Sakurama, Takashi Yorifuji, Munenori Takaoka, Yasuhiro Fujiwara, Narutoshi Kabashima, Daisuke Azuma, Takahiro Hirayama, Kohei Tsukahara, Sunao Morisada, Atsuyoshi Iida, Keitaro Tada, Naoki Shiba, Nobuo Sato, Shingo Ichiba, Koichi Kino, Masaki Fukushima, Yoshihito Ujike

Acta Medica Okayama 66 ( 6 ) 443 - 447 2012

Methyl Mercury Exposure at Niigata, Japan: Results of Neurological Examinations of 103 Adults Reviewed

Kimio Maruyama, Takashi Yorifuji, Toshihide Tsuda, Tomoko Sekikawa, Hiroto Nakadaira, Hisashi Saito

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 2012

The role of medicine in the decline of post-War infant mortality in Japan Reviewed

Takashi Yorifuji, Shinichi Tanihara, Sachiko Inoue, Soshi Takao, Ichiro Kawachi

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY 25 ( 6 ) 601 - 608 2011.11

Diesel vehicle emission and death rates in Tokyo, Japan: A natural experiment Reviewed

Takashi Yorifuji, Ichiro Kawachi, Mariko Kaneda, Soshi Takao, Saori Kashima, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 409 ( 19 ) 3620 - 3627 2011.9

Regional disparities in compliance with tobacco control policy in Japan: an ecological analysis Reviewed

Takashi Yorifuji, Shinichi Tanihara, Soshi Takao, Ichiro Kawachi

TOBACCO CONTROL 20 ( 5 ) 374 - 379 2011.9

Acute non-cancer mortality excess after polychlorinated biphenyls and polychlorinated dibenzofurans mixed exposure from contaminated rice oil: Yusho Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda

SCIENCE OF THE TOTAL ENVIRONMENT 409 ( 18 ) 3288 - 3294 2011.8

Environmental Health Research Implications of Methylmercury

Toshihide Tsuda, Takashi Yorifuji, Masazumi Harada

ENVIRONMENTAL HEALTH PERSPECTIVES 119 ( 7 ) A284 - A284 2011.7

Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan Reviewed

Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada

ENVIRONMENT INTERNATIONAL 37 ( 5 ) 907 - 913 2011.7

Environmental factors and seasonal influenza onset in Okayama city, Japan: case-crossover study.

Tsuchihashi Y, Yorifuji T, Takao S, Suzuki E, Mori S, Doi H, Tsuda T

Acta Med Okayama. 65 ( 2 ) 97 - 103 2011.4

Residential proximity to heavy traffic and birth weight in Shizuoka, Japan Reviewed

Saori Kashima, Hiroo Naruse, Takashi Yorifuji, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

ENVIRONMENTAL RESEARCH 111 ( 3 ) 377 - 387 2011.4

Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury Reviewed

Takashi Yorifuji, Frodi Debes, Pal Weihe, Philippe Grandjean

Neurotoxicology and Teratology 33 ( 2 ) 205 - 211 2011.3

Associations of Outdoor Air Pollution With Hemorrhagic Stroke Mortality Reviewed

Takashi Yorifuji, Ichiro Kawachi, Tetsuro Sakamoto, Hiroyuki Doi

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 53 ( 2 ) 124 - 126 2011.2

Increased Risk of Lung Cancer Mortality Among Residents Who Had Lived Near an Asbestos Product Manufacturing Plant Reviewed

Shinji Kumagai, Norio Kurumatani, Toshihide Tsuda, Takashi Yorifuji, Etsuji Suzuki

EPIDEMIOLOGY 22 ( 1 ) S75 - S76 2011.1

The History of Minamata Disease and Public Health Policy Reviewed

Toshihide Tsuda, Takashi Yorifuji

EPIDEMIOLOGY 22 ( 1 ) S99 - S99 2011.1

Residential Proximity to Major Roads and Preterm Births Reviewed

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

EPIDEMIOLOGY 22 ( 1 ) 74 - 80 2011.1

Recent Findings in Minamata Disease From a Population-based Study Conducted in 1971 Reviewed

Takashi Yorifuji, Toshihide Tsuda, Masazumi Harada

EPIDEMIOLOGY 22 ( 1 ) S99 - S100 2011.1

Epidemiology of Congenital Minamata Disease Patients Reviewed

Masazumi Harada, Takashi Yorifuji, Toshihide Tsuda

EPIDEMIOLOGY 22 ( 1 ) S100 - S100 2011.1

Environmental Exposure to Asbestos and Pleural Plaques Among Retirees in a Factory Without Asbestos Use in H City, Japan Reviewed

Takashi Yorifuji, Etsuji Suzuki, Toshihide Tsuda, Yuji Natori, Eisuke Matsui

EPIDEMIOLOGY 22 ( 1 ) S76 - S76 2011.1

Acute and Long-term Excess Mortality After Polychlorinated Biphenyls and Polychlorinated Dibenzofurans Mixed Exposure From Contaminated Rice Oil: Yusho Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda

EPIDEMIOLOGY 22 ( 1 ) S239 - S239 2011.1

Cancer excess after arsenic exposure from contaminated milk powder Reviewed

Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi, Philippe Grandjean

Environmental Health and Preventive Medicine 16 ( 3 ) 164 - 170 2011

Oseltamivir and Abnormal Behavior response Reviewed

Takashi Yorifuji, Etsuji Suzuki, Toshihide Tsuda

EPIDEMIOLOGY 21 ( 6 ) 916 - 916 2010.11

The authors respond Reviewed

Takashi Yorifuji, Etsuji Suzuki, Toshihide Tsuda

EPIDEMIOLOGY 21 ( 6 ) 916 2010.11

Increased Risk of Lung Cancer Mortality among Residents near an Asbestos Product Manufacturing Plant Reviewed

Shinji Kumagai, Norio Kurumatani, Toshihide Tsuda, Takashi Yorifuji, Etsuji Suzuki

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 16 ( 3 ) 268 - 278 2010.7

Factors Affecting Appropriate Management of Patients with Sexually Transmitted Infections in Japan Reviewed

Tomoe Kodama, Katsumi Nakase, Toshihide Tsuda, Takashi Yorifuji, Hiroyuki Doi

ACTA MEDICA OKAYAMA 64 ( 3 ) 171 - 179 2010.6

Is There Any Association between TV Viewing and Obesity in Preschool Children in Japan? Reviewed

Ayako Sasaki, Takashi Yorifuji, Toshihide Iwase, Hirokazu Komatsu, Soshi Takao, Hiroyuki Doi

ACTA MEDICA OKAYAMA 64 ( 2 ) 137 - 142 2010.4

Physical Activity and Mortality Risk in the Japanese Elderly A Cohort Study Reviewed

Kazumune Ueshima, Kazuko Ishikawa-Takata, Takashi Yorifuji, Etsuji Suzuki, Saori Kashima, Soshi Takao, Masumi Sugiyama, Toshiki Ohta, Hiroyuki Doi

AMERICAN JOURNAL OF PREVENTIVE MEDICINE 38 ( 4 ) 410 - 418 2010.4

Effects of Traffic-Related Outdoor Air Pollution on Respiratory Illness and Mortality in Children, Taking Into Account Indoor Air Pollution, in Indonesia Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda, Juliani Ibrahim, Hiroyuki Doi

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 52 ( 3 ) 340 - 345 2010.3

Unusual Cancer Excess After Neonatal Arsenic Exposure From Contaminated Milk Powder Reviewed

Takashi Yorifuji, Toshihide Tsuda, Philippe Grandjean

JOURNAL OF THE NATIONAL CANCER INSTITUTE 102 ( 5 ) 360 - 361 2010.3

Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan Reviewed

Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Hiroyuki Doi, Masumi Sugiyama, Kazuko Ishikawa-Takata, Toshiki Ohta

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 67 ( 2 ) 111 - 117 2010.2

Long-term exposure to methylmercury and its effects on hypertension in Minamata Reviewed

Takashi Yorifuji, Toshihide Tsuda, Saori Kashima, Soshi Takao, Masazumi Harada

ENVIRONMENTAL RESEARCH 110 ( 1 ) 40 - 46 2010.1

What has methylmercury in umbilical cords told us? - Minamata disease Reviewed

Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Masazumi Harada

SCIENCE OF THE TOTAL ENVIRONMENT 408 ( 2 ) 272 - 276 2009.12

Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort Reviewed

Etsuji Suzuki, Takashi Yorifuji, Soshi Takao, Hirokazu Komatsu, Masumi Sugiyama, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

Annals of Epidemiology 19 ( 10 ) 732 - 739 2009.10

Sleep duration, sleep quality and cardiovascular disease mortality among the elderly: A population-based cohort study Reviewed

Etsuji Suzuki, Takashi Yorifuji, Kazumune Ueshima, Soshi Takao, Masumi Sugiyama, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

PREVENTIVE MEDICINE 49 ( 2-3 ) 135 - 141 2009.8

UNSCEAR 2006 inadequately cited "A case control study of multiple myeloma at four nuclear facilities" (Ann Epidemiol 2000; 10: 144-153. by Wing S et al.) Reviewed

Toshihide Tsuda, Eiji Yamamoto, Takashi Yorifuji

ANNALS OF EPIDEMIOLOGY 19 ( 7 ) 519 - 519 2009.7

Oseltamivir and Abnormal Behaviors True or Not? Reviewed

Takashi Yorifuji, Etsuji Suzuki, Toshihide Tsuda

EPIDEMIOLOGY 20 ( 4 ) 619 - 621 2009.7

GREEN TEA CONSUMPTION AND MORTALITY AMONG JAPANESE ELDERLY: A POPULATION-BASED COHORT STUDY Reviewed

E. Suzuki, T. Yorifuji, S. Takao, H. Komatsu, M. Sugiyama, H. Doi

AMERICAN JOURNAL OF EPIDEMIOLOGY 169 S83 - S83 2009.6

Application of land use regression to regulatory air quality data in Japan Reviewed

Saori Kashima, Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi

SCIENCE OF THE TOTAL ENVIRONMENT 407 ( 8 ) 3055 - 3062 2009.4

Minamata disease: Catastrophic poisoning due to a failed public health response Reviewed

Toshihide Tsuda, Takashi Yorifuji, Soshi Takao, Masaya Miyai, Akira Babazono

JOURNAL OF PUBLIC HEALTH POLICY 30 ( 1 ) 54 - 67 2009.4

Total Mercury Content in Hair and Neurologic Signs Historic Data From Minamata Reviewed

Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

EPIDEMIOLOGY 20 ( 2 ) 188 - 193 2009.3

Impact of Breastfeeding on Body Weight of Preschool Children in a Rural Area of Japan: Population-based Cross-sectional Study Reviewed

Hirokazu Komatsu, Takashi Yorifuji, Toshibide Iwase, Ayako Sasaki, Soshi Takao, Hiroyuki Doi

ACTA MEDICA OKAYAMA 63 ( 1 ) 49 - 55 2009.2

Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Morality in Japan: Shizuoka Study Reviewed

T. Yorifuji, S. Kashima, E. Suzuki, S. Takao, T. Tsuda, M. Sugiyama, H. Doi

EPIDEMIOLOGY 19 ( 6 ) S195 - S195 2008.11

Causal interpretation based on DAGs Reviewed

Etsuji Suzuki, Hirokazu Komatsu, Takashi Yorifuji, Toshihide Tsuda

EPIDEMIOLOGY 19 ( 2 ) 361 - 361 2008.3

Long-term exposure to methylmercury and neurologic signs in Minamata and neighboring communities Reviewed

Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Masazumi Harada

EPIDEMIOLOGY 19 ( 1 ) 3 - 9 2008.1

Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury Reviewed

Takashi Yorifuji, Toshihide Tsuda, Norito Kawakami

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 80 ( 8 ) 679 - 688 2007.8

Health impact assessment of particulate matter in Tokyo, Japan Reviewed

Takashi Yorifuji, Eiji Yamamoto, Toshihide Tsuda, Norito Kawakami

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 60 ( 4 ) 179 - 185 2005.7

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