Faculty Profiles - YORIFUJI Takashi

Papers - YORIFUJI Takashi

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Non-woven Masks and SARS-CoV-2 Infection in a Cluster Setting in Japan Reviewed

Yukari Takahashi, Soshi Takao, Tomoka Kadowaki, Naomi Matsumoto, Takashi Yorifuji

Japanese Journal of Infectious Diseases 78 ( 2 ) 110 - 113 2025.3

Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries Reviewed

Tetsuya Yumoto, Takafumi Obara, Takashi Hongo, Atsuyoshi Iida, Kohei Tsukahara, Morihiro Katsura, Yutaka Kondo, Hideto Yasuda, Shigeki Kushimoto, Takashi Yorifuji, Hiromichi Naito, Atsunori Nakao, Tetsuya Yumoto, Atsuyoshi Iida, Morihiro Katsura, Yutaka Kondo, Hideto Yasuda, Shigeki Kushimoto, Hiromichi Naito, Tomoya Ito, Motoyoshi Yamamoto, Yoshihiro Yamamoto, Hiroto Manase, Nozomi Takahashi, Akinori Osuka, Suguru Annen, Nobuki Ishikawa, Kazushi Takayama, Keita Minowa, Kenichi Hakamada, Akari Kusaka, Mineji Hayakawa, Shota Kawahara, Satoshi Hirano, Marika Matsumoto, Kohei Kusumoto, Hiroshi Kodaira, Chika Kunishige, Keiichiro Toma, Yusuke Seino, Michio Kobayashi, Masaaki Sakuraya, Takafumi Shinjo, Shigeru Ono, Haruka Taira, Kazuhiko Omori, Yoshio Kamimura, Atsushi Shiraishi, Rei Tanaka, Yukihiro Tsuzuki, Yukio Sato, Noriaki Kyogoku, Masafumi Onishi, Kaichi Kawai, Kazuyuki Hayashida, Keiko Terazumi, Akira Kuriyama, Susumu Matsushime, Osamu Takasu, Toshio Morita, Nagato Sato, Wataru Ishii, Michitaro Miyaguni, Shingo Fukuma, Yosuke Nakabayashi, Yoshimi Ohtaki, Kiyoshi Murata, Masayuki Yagi, Tadashi Kaneko, Shigeru Takamizawa, Akihiro Yasui, Yasuaki Mayama, Masafumi Gima, Ichiro Okada, Asuka Tsuchiya, Koji Ishigami, Yukiko Masuda, Yasuo Yamada, Hiroshi Yasumatsu, Kenta Shigeta, Kohei Kato, Fumihito Ito, Yoshitaka Saegusa, Tomohiko Azuma, Shima Asano, Takehiro Umemura, Norihiro Goto, Takao Yamamoto, Junichi Ishikawa, Elena Yukie Uebayashi, Shunichiro Nakao, Yuko Ogawa, Takashi Irinoda, Yuki Narumi, Miho Asahi, Takayuki Ogura, Takashi Hazama, Shokei Matsumoto, Daisuke Miyamoto, Keisuke Harada, Narumi Kubota, Yusuke Konda, Takeshi Asai, Tomohiro Muronoi, Kazuhide Matsushima, Toru Hifumi, Kasumi Shirasaki, Shigeyuki Furuta, Atsuko Fujikawa, Makoto Takaoka, Kaori Ito, Satoshi Nara, Atsushi Tanikawa, Masato Tsuchikane, Naoya Miura, Naoki Sakoda, Tadaaki Takada, Shogo Shirane, Akira Endo, Keita Nakatsutsumi, Kenta Sugiura, Yusuke Hagiwara, Tamotsu Gotou

Scientific Reports 15 ( 1 ) 8502 - 8502 2025.3

Impact of coronavirus disease 2019 emergency declarations on surgeries for deep neck infection incidence in Japan Reviewed

Kensuke Uraguchi, Naomi Matsumoto, Shohei Fujimoto, Takashi Yorifuji, Mizuo Ando

Journal of Infection and Chemotherapy 31 ( 3 ) 102601 - 102601 2025.3

Efficacy of telerehabilitation for patients after hip fracture surgery: A systematic review and meta-analysis Reviewed

Takahiro Tsuge, Norio Yamamoto, Shunsuke Taito, Takanori Miura, Daijo Shiratsuchi, Takashi Yorifuji

Journal of Telemedicine and Telecare 31 ( 2 ) 174 - 183 2025.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Introduction

This study aimed to determine the efficacy of telerehabilitation for patients after hip fracture surgery through a systematic review and meta-analysis.

Methods

Eight electronic databases were searched in August 2022. The primary outcomes were mobility outcomes, activities of daily living (ADL) outcomes, and all adverse events, whereas the secondary outcomes were pain, health-related quality of life, and fall efficacy scale score.

Results

Seven randomized controlled trials were eligible for this study. The evidence regarding the effect of telerehabilitation on mobility outcomes (standardized mean difference (SMD): 0.05, 95% confidence interval (CI): −0.39 to 0.48) and all adverse events (risk ratio: 1.14, 95% CI: 0.62 to 2.21) was very uncertain. A clinically irrelevant but significant mean difference (MD) in ADL outcomes was found (MD: 4.82, 95% CI: 2.63 to 7.01). Telerehabilitation may result in a slight increase in fall efficacy scale score (SMD: 0.26, 95% CI: −0.02 to 0.54) and little to no difference in pain (MD: −1.0, 95% CI: −18.31 to 16.31).

Conclusions

The efficacy of telerehabilitation for patients after hip fracture surgery was uncertain with respect to the mobility outcomes, all adverse events, and pain, with no clinically meaningful differences in ADL outcomes. Telerehabilitation may be necessary to be considered for patients after hip fracture surgery to improve their confidence in their ability to perform daily activities without falling. Therefore, medical staff may consider telerehabilitation for hip fractures.

DOI： 10.1177/1357633x231181632

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Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/1357633X231181632

Outdoor playing during preschool was associated with a reduced risk of school‐age obesity in Japan Reviewed

Takahiro Tsuge, Naomi Matsumoto, Soshi Takao, Takashi Yorifuji

Acta Paediatrica 114 ( 2 ) 303 - 309 2025.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Aim

This study investigated the association between outdoor play habits during preschool and school‐age obesity.

Methods

We conducted a longitudinal cohort study of all children born in Japan during 2 weeks in January and July 2001. We defined outdoor play habits at age 2.5 years (third survey) as exposure, while parent‐reported height and weight at age 7 years (seventh survey) were defined as overweight and obesity status using the WHO reference. Logistic regression models were used to estimate odds ratios (ORs) for associations between preschool outdoor play habits and school‐age obesity, adjusting for parental and child factors.

Results

Of 53 575 children born, 42 812 had data on outdoor play habits at age 2.5 years, with 91% (38 970) having such habits. At age 7 years, 31 743/42 812 (74%) children had height and weight data, with 3249/31 743 (10%) classified as overweight or obesity (BMI SD score ≥1.0). Outdoor play habits were negatively associated with obesity (adjusted OR 0.85, 95% confidence interval (CI): 0.74–0.97).

Conclusion

Outdoor play habits in early preschool years are associated with a reduced risk of school‐age obesity. Parents and caregivers may consider encouraging their children to outdoor play habits at an early age to help prevent obesity later in life.

DOI： 10.1111/apa.17441

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Association Between Dinner-to-Bed Time and Gastroesophageal Reflux-Related Diseases in Children Reviewed

Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

Cureus 17 ( 1 ) e77709 - e77709 2025.1

Cesarean delivery on child health and development in Japanese nationwide birth cohort Reviewed

Naomi Matsumoto, Takashi Mitsui, Kei Tamai, Tomoya Hirota, Hisashi Masuyama, Takashi Yorifuji

Scientific Reports 15 ( 1 ) 2485 - 2485 2025.1

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world’s lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997–1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups.

DOI： 10.1038/s41598-025-87043-2

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Other Link： https://www.nature.com/articles/s41598-025-87043-2

Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan. Reviewed

Shigehara K., Matsumoto N., Tsuge M., Uda K., Saito Y., Yashiro M., Yorifuji T., Ikeda M., Tsukahara H.

Allergy Asthma Clin Immunol. 21 ( 1 ) 4 - 4 2025.1

Impact of high blood pressure on the risk of mortality among Japanese people aged 65 years and older Reviewed

Akagi S., Takao S., Matsuo R., Matsumoto N., Yorifuji T.

Geriatr Gerontol Int. 25 ( 1 ) 82 - 89 2025.1

ABCC8 haploinsufficiency in a mother-daughter pair with young-onset diabetes with and without neonatal hypoglycemia. Reviewed

Uehara E., Shimura N., Matsubara K., Kageyama I., Yorifuji T., Fukami M.

Clin Pediatr Endocrinol. 34 ( 1 ) 66 - 69 2025.1

In Vitro Fertilization and Long-Term Child Health and Development: Nationwide birth cohort study in Japan Reviewed

Matsumoto N., Mitsui T., Kadowaki T., Mitsuhashi T., Hirota T., Masuyama H., Yorifuji T.

Eur J Pediatr. 184 ( 1 ) 24 - 24 2024.11

A nationwide longitudinal survey of infantile injury and its recurrence in Japan. Reviewed

Hiraoka T., Obara T., Matsumoto N., Tsukahara K., Hongo T., Nojima T., Hisamura M., Yumoto T., Nakao A., Yorifuji T., Naito H.

Sci Rep. 14 ( 1 ) 24716 - 24716 2024.10

Respiratory Severity Score and Neurodevelopmental Outcomes at Age 3 Years in Extremely Preterm Infants Reviewed

Tamai K, Takeuchi A, Nakamura M, Matsumoto N, Yorifuji T, Kageyama M

American Journal of Perinatology 41 ( 13 ) 1841 - 1847 2024.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Georg Thieme Verlag KG

Objective We aimed to examine the association between respiratory severity score (RSS; mean airway pressure × fraction of inspired oxygen) and neurodevelopmental outcomes in extremely preterm infants.

Study Design This was a single-center, retrospective cohort study. We analyzed data from extremely preterm infants who were admitted to the neonatal intensive care unit at Okayama Medical Center between 2010 and 2019. Infants without invasive respiratory management during the first day of life were excluded. The exposure variable was the highest RSS during the first day of life. RSS was categorized into two groups: low (<3.5) and high (≥3.5) RSS. The primary outcome was death or neurodevelopmental impairment at age 3 years, defined as cognitive impairment (developmental quotient <70) or the presence of cerebral palsy. Secondary outcomes were the components of the primary outcome. We conducted robust Poisson regression analyses to investigate the association between RSS category and primary and secondary outcomes, adjusting for perinatal confounders.

Results The cohort included 97 infants with neurodevelopmental data, of whom 34 and 63 infants were in the low- and high-RSS categories, respectively. The median (interquartile range) gestational age and birth weight were 26.0 (24.7–26.9) and 25.7 (24.6–26.7) weeks and 761 (584–866) and 806 (618–898) g for infants in the low- and high-RSS categories, respectively. Compared with infants in the low-RSS category, those in the high-RSS category had a greater risk of death or neurodevelopmental impairment at age 3 years (26.3 vs. 42.3%; adjusted risk ratio [RR], 2.0; 95% confidence interval [CI], 1.1–3.5) and neurodevelopmental impairment at age 3 years (17.6 vs. 28.6%; adjusted RR, 2.7; 95% CI, 1.3–5.9).

Conclusion High RSS (≥3.5) during the first day of life was associated with an increased risk of neurodevelopmental impairment at age 3 years in extremely preterm infants.

Key Points

DOI： 10.1055/a-2267-4719

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Prognostic performance of gray-white matter ratio in adult out-of-hospital cardiac arrest patients after receiving extracorporeal cardiopulmonary resuscitation Reviewed

Hongo T, Naito H, Nasu M, Yumoto T, Kosaki Y, Yorifuji T, Hifumi T, Inoue A, Sakamoto T, Kuroda Y, Nakao A, SAVE-J II Study Group

Resuscitation 203 110351 - 110351 2024.10

Neurectomy for allergic rhinitis in Japan: Increasing trends and surgeon preferences Reviewed

Makihara S, Hosoya K, Uraguchi K, Maeda Y, Komachi T, Yorifuji T, Ando M, Matsune S, Okubo K

Auris Nasus Larynx 51 ( 5 ) 834 - 839 2024.10

Zinc deficiency is a potential risk factor for COVID-19 progression to pneumonia requiring oxygen therapy Reviewed

Fujita K, Ocho K, Kadowaki T, Yorifuji T, Hagiya H, Otsuka F

Journal of Infection and Chemotherapy 30 ( 10 ) 978 - 982 2024.10

Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan Reviewed

Takanaga S., Matsumoto N., Kadowaki T., Takao S., Yorifuji T.

Acta Med Okayama. 78 ( 5 ) 363 - 370 2024.10

Postnatal weight loss and neurodevelopmental outcomes at age 3 years in extremely preterm infants: a cohort study. Reviewed

Tamai K., Matsumoto N., Yorifuji T., Takeuchi A., Nakamura M., Kageyama M.

BMC Pediatr. 24 ( 1 ) 618 - 618 2024.9

Antibody Titers and the Risk of Infection During the SARS-CoV-2 Omicron Phase in Bizen City, Japan Reviewed

Kadowaki T, Sasaki A, Matsumoto N, Mitsuhashi T, Hagiya H, Takao S, Yorifuji T

The Journal of Infectious Diseases 230 ( 3 ) 662 - 669 2024.9

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Understanding the association between the immune response and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has implications for forthcoming prevention strategies. We evaluated the association between antibody titers and the risk of infection for the general population during the Omicron-dominant phase.

Methods

This was a prospective cohort study of residents or people affiliated with institutions in Bizen City, which included 1899 participants. We measured the titers of antibodies against SARS-CoV-2 repeatedly every 2 months from June 2022 to March 2023. Infection status was obtained from self-reported questionnaires and the official registry. We estimated risk ratios (RRs) for infection within 2 months of the date of each antibody measurement with 95% confidence intervals (CIs) based on antibody titer categories and spline functions.

Results

Compared with the &lt;2500 arbitrary unit (AU)/mL category, the 2500–5000, 5000–10 000, and ≥10 000 AU/mL categories had adjusted RRs of 0.81 (95% CI, .61–1.08), 0.51 (95% CI, .36–.72), and 0.41 (95% CI, .31–.54), respectively. The spline function showed a nonlinear relationship between antibody titer and risk.

Conclusions

Higher antibody titers were associated with a lower risk. We demonstrate the usefulness of measuring an antibody titers to determine the appropriate timing for future prevention strategies.

DOI： 10.1093/infdis/jiae207

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Efficacy of Protein and Essential Amino Acid Supplementation in Lower Limb Surgeries: A Systematic Review and Meta-Analysis. Reviewed

Hagiyama A., Yamamoto N., Watanabe J., Tsuge T., Nakashima Y., Nakao S., Sato H., Yorifuji T.

Cureus. 16 ( 9 ) e69212 - e69212 2024.9

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Papers - YORIFUJI Takashi