研究者詳細 - 宮﨑　育子

論文 - 宮﨑　育子

分割表示 151 件中 141 - 151 件目／全件表示 >>

Progressive cortical atrophy after forebrain ischemia in diabetic rats 査読

Fumio Kondo, Masato Asanuma, Ikuko Miyazaki, Yoichi Kondo, Ken-ichi Tanaka, Hirohumi Makino, Norio Ogawa

Neuroscience Research 39 ( 3 ) 339 - 346 2001年3月

Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. 査読

Aoki Sogawa Chiharu, Asanuma Masato, Sogawa Norio, Miyazaki Ikuko, Nakanishi Tohru, Furuta Hiroaki, Ogawa Noriko

Acta Medica Okayama 55 ( 1 ) 1 - 9 2001年2月

記述言語：英語出版者・発行元：Okayama University Medical School

<p>The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.</p>

DOI： 10.18926/AMO/32031

Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist 査読

Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Md Emdadul Haque, Masato Asanuma, Norio Ogawa

Neurochemical Research 26 ( 1 ) 31 - 36 2001年

Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g) 査読

Chiharu Aoki Sogawa, Ikuko Miyazaki, Norio Sogawa, Masato Asanuma, Norio Ogawa, Hiroaki Furuta

Brain Research 853 ( 2 ) 310 - 316 2000年1月

Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist 査読

Motoyuki Iida, Ikuko Miyazaki, Ken-Ichi Tanaka, Hideaki Kabuto, Emi Iwata-Ichikawa, Norio Ogawa

Brain Research 838 ( 1-2 ) 51 - 59 1999年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Recent information suggests that free radicals are closely involved in the pathogenesis and/or progression of Parkinson's disease (PD). High-dose levodopa therapy has been suggested to increase oxidative stress, thereby accelerating the progression of PD. Based on this viewpoint, free radical scavenging, antioxidant and neuroprotective agents which may prevent the progression of PD have recently attracted considerable attention. For example, ergot derivative dopamine (DA) agonists have been reported to scavenge free radicals in vitro and show a neuroprotective effect in vivo. Non-ergot DA agonists have also recently been used in the treatment of PD despite the lack of substantial evidence for any free radical scavenging activity or antioxidant activity. The present study was conducted to assess the in vitro free radical scavenging and antioxidant activities of ropinirole, a non-ergot DA agonist, as well as its glutathione (GSH), catalase and superoxide dismutase (SOD) activating effects and neuroprotective effect in vivo. Ropinirole scavenges free radicals and suppresses lipid peroxidation in vitro, but these activities are very weak, suggesting that the antioxidant effect of ropinirole observed in vitro may be a minor component of its neuroprotective effect in vivo. Administration of ropinirole for 7 days increased GSH, catalase and SOD activities in the striatum and protected striatal dopaminergic neurons against 6- hydroxydopamine (6-OHDA) in mice. Pre-treatment with sulpiride prevented ropinirole from enhancing striatal GSH, catalase and SOD activities and abolished the protection of dopaminergic neurons against 6-OHDA. Our findings indicate that activation of GSH, catalase and SOD mediated via DA D2 receptors may be the principal mechanism of neuroprotection by ropinirole.

DOI： 10.1016/S0006-8993(99)01688-1

Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia 査読

Yoichi Kondo, Masato Asanuma, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

Neurochemical Research 24 ( 1 ) 9 - 13 1999年

Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis 査読

Emi Iwata-Ichikawa, Yoichi Kondo, Ikuko Miyazaki, Masato Asanuma, Norio Ogawa

Journal of Neurochemistry 72 ( 6 ) 2334 - 2344 1999年

記述言語：英語掲載種別：研究論文（学術雑誌）

We examined the effects of oxidative stress on rat cultured mesencephalic neurons and glial cells. Glial cells were more resistant to 6- hydroxydopamine (6-OHDA) and H2O2 toxicity than neurons. In glial cells, incubation with 6-OHDA and H2O2 induced a significant increase in the expression of γ-glutamylcysteine synthetase (the rate-limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA- response element (TRE)-binding activity. Furthermore, a subsequent elevation in cellular total glutathione content was also observed. In neurons, both agents decreased TRE-binding activity, and these cells failed to up-regulate the glutathione synthesis. We also examined the mechanisms of the neuroprotective effects of glial cells using a gila conditioned medium. Neurons maintained in gila conditioned medium up-regulated the level of TRE- binding activity, γ-glutamylcysteine synthetase mRNA expression, and total glutathione content in response to 6-OHDA or H2O2, and became more resistant to both agents than cells maintained in a normal medium. Neurons maintained in normal medium failed to up-regulate the glutathione synthesis. Our results suggest that transcriptional up-regulation of glutathione synthesis in glial cell appears to mediate brain glial cell resistance against oxidative stress, and that glial cells protect neurons via transcriptional up-regulation of the antioxidant system.

DOI： 10.1046/j.1471-4159.1999.0722334.x

Scopus

PubMed

researchmap

マウス脳内における鉄結合蛋白ラクトフェリンの分布

近藤洋一, 岩田恵美, 宮崎育子, 相見良成, 遠山育夫, 木村宏, 小川紀雄

神経化学 37 ( 3 ) 488 - 488 1998年9月

Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line 査読

Emi Iwata, Ikuko Miyazaki, Masato Asanuma, Azusa Iida, Norio Ogawa

Neuroscience Letters 251 ( 1 ) 49 - 52 1998年7月

Effects of repeated cyclosporin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain 査読

Kyoko Iida, Emi Iwata, Masato Asanuma, Sakiko N Asanuma, Marvin Gómez-Vargas, Ikuko Miyazaki, Tohru Nakanishi, Norio Ogawa

Neuroscience Research 30 ( 2 ) 185 - 193 1998年2月

Aniracetam ameriorates impaired pre-and post-synaptic cholinergic indices in gerbil hippocampus induced by transient forebrain ischemia. 査読

Yoichi Kondo, Masato Asanuma, Hideaki Kabuto, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

J. Brain Sci. 23 250 - 260 1997年

　前のページ - 次のページ　

<宮﨑 育子>

論文 - 宮﨑 育子

<宮﨑　育子>

論文 - 宮﨑　育子