研究者詳細 - 宮﨑　育子

論文 - 宮﨑　育子

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遺伝子改変によるパーキンソン病モデル．

浅沼幹人, 宮崎育子

脳の科学 292,165-170 2004年

ドパミン受容体とトランスポーター．

小川紀雄, 宮崎育子

脳の科学 292,53-59 2004年

Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases 査読

Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

CURRENT PHARMACEUTICAL DESIGN 10 ( 6 ) 695 - 700 2004年

記述言語：英語出版者・発行元：BENTHAM SCIENCE PUBL LTD

It is well known that nonsteroidal anti-inflammatory drugs (NSAIDs) possess anti-inflammatory, analgesic and antipyretic properties by inhibiting cyclooxygenase (COX), a prostaglandin-synthesizing enzyme. It has also been revealed that NSAIDs exert inhibitory effects on the generating system of nitric oxide radicals and modulating effects on transcription factors which are related to inflammatory reactions including cytokine expression. Recently, a number of studies have been conducted focusing on the neuroprotective effects of NSAIDs, since it has been reported that inflammatory processes are associated with the pathogenesis of several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. In the experimental model of Parkinson's disease, NSAIDs have also exerted neuroprotective effects which are based not only on their COX-inhibiting effects but also on other properties: inhibitory effects on nitric oxide synthesis, action as agonists for peroxisome proliferator-activated receptor gamma, and some unknown pharmacological effects. In this article, various pharmacological effects of NSAIDs except their inhibitory action on COX are reviewed, and possible neuroprotective effects of NSAIDs have been discussed on neurodegenerative diseases, especially Parkinson's disease.

DOI： 10.2174/1381612043453072

Web of Science

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PP4-061 抗体アレイを用いた下部尿路閉塞モデルラット膀胱平滑筋層におけるタンパク発現のprofiling(一般演題(ポスター))

藤田治, 横山光彦, 浅沼幹人, 宮崎育子, 小川紀雄, 公文裕巳

日本泌尿器科学会雑誌 95 ( 2 ) 545 - 545 2004年

Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketaprofen a non-steroidal anti-inflammatory drug 査読

ASANUMA M

Neurosci Lett 352 ( 1 ) 13 - 16 2003年11月

Overexpression of Cu–Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level 査読

M.Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

Neuroscience Research 47 ( 1 ) 31 - 37 2003年9月

Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells 査読

M Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

Biochimica et Biophysica Acta (BBA) - General Subjects 1619 ( 1 ) 39 - 52 2003年1月

アルツハイマー病脳で減少しているgrowth inhibitory factor (GIF) の加齢にともなう変化．

浅沼幹人, 宮崎育子, 東洋一郎, 田中健一, 小川紀雄

分子精神医学 2003年

ドパミンおよびその誘導体のキノン体生成を介したアポトーシス誘導性．

浅沼幹人, 宮崎育子, Haque ME, 東洋一郎, 小川紀雄

Prog Med 2003年

非ステロイド性消炎鎮痛薬の神経保護作用の新展開．

浅沼幹人, 宮崎育子, 辻武史, 小川紀雄

日本神経精神薬理学会雑誌 23,111-119 2003年

Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease 査読

Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

NEUROTOXICITY RESEARCH 5 ( 3 ) 165 - 176 2003年

記述言語：英語出版者・発行元：F P GRAHAM PUBLISHING CO

Dopamine (DA)- or L-dihydroxyphenylalanine- (L-DOPA-) induced neurotoxicity is thought to be involved not only in adverse reactions induced by long-term L-DOPA therapy but also in the pathogenesis of Parkinson!s disease. Numerous in vitro and in vivo studies concerning DA- or L-DOPA-induced neurotoxicity have been reported in recent decades. The reactive oxygen or nitrogen species generated in the enzymatical oxidation or auto-oxidation of an excess amount of DA induce neuronal damage and/or apoptotic or non-apoptotic cell death; the DA-induced damage is prevented by various intrinsic and extrinsic antioxidants. DA and its metabolites containing two hydroxyl residues exert cytotoxicity in dopaminergic neuronal cells mainly due to the generation of highly reactive DA and DOPA quinones which are dopaminergic neuron-specific cytotoxic molecules. DA and DOPA quinones may irreversibly alter protein function through the formation of 5-cysteinyl-catechols on the proteins. For example, the formation of DA quinone-alpha-synuclein consequently increases cytotoxic protofibrils and the covalent modification of tyrosine hydroxylase by DA quinones. The melanin-synthetic enzyme tyrosinase in the brain may rapidly oxidize excess amounts of cytosolic DA and L-DOPA, thereby preventing slowly progressive cell damage by auto-oxidation of DA, thus maintaning DA levels. Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in long-term L-DOPA-treated Parkinson's disease patients.

DOI： 10.1007/BF03033137

Web of Science

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The p53-activated Gene, PAG608, Requires a Zinc Finger Domain for Nuclear Localization and Oxidative Stress-induced Apoptosis 査読

Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, M. Emdadul Haque, Naoko Fujita, Ken-ichi Tanaka, Norio Ogawa

Journal of Biological Chemistry 277 ( 44 ) 42224 - 42232 2002年11月

Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain 査読

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Ken-ichi Tanaka, Md Emdadul Haque, Naoko Fujita, Norio Ogawa

Neuroscience Letters 327 ( 1 ) 61 - 65 2002年7月

The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals 査読

Michiyo Yoshioka, Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Youichirou Higashi, Masato Asanuma, Norio Ogawa

Neuroscience Research 43 ( 3 ) 259 - 267 2002年7月

Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice 査読

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Jean Lud Cadet, Norio Ogawa

Neuroscience Letters 325 ( 3 ) 191 - 194 2002年6月

GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum 査読

Ken-ichi Tanaka, Michiyo Yoshioka, Ikuko Miyazaki, Naoko Fujita, Norio Ogawa

Neuroscience Letters 321 ( 1-2 ) 45 - 48 2002年3月

Inhibition of Tyrosinase Reduces Cell Viability in Catecholaminergic Neuronal Cells 査読

Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

Journal of Neurochemistry 75 ( 4 ) 1771 - 1774 2002年1月

ニューロメラニン合成酵素チロシナーゼのドパミン神経障害への関与．

浅沼幹人, 東洋一郎, 宮崎育子, 小川紀雄

Prog Med 2002年

Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content 査読

Ken-ichi Tanaka, Naoko Wada-Tanaka, Ikuko Miyazaki, Masahiko Nomura, Norio Ogawa

Neurochemical Research 27 ( 4 ) 331 - 336 2002年

Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals 査読

Masato Asanuma, Sakiko Nishibayashi-Asanuma, Ikuko Miyazaki, Masahiro Kohno, Norio Ogawa

Journal of Neurochemistry 76 ( 6 ) 1895 - 1904 2001年12月

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