Faculty Profiles - ZAMAMI Yoshito

MISC - ZAMAMI Yoshito

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Effect of Postprandial Hyperglycemia and Hyperinsulinemia on Vascular Responsiveness

ZAMAMI YOSHITO, TAKATORI SHINGO, IWATANI YUKIKO, YAMAWAKI KOSUKE, MIYASHITA SATOKO, YABUMAE NANA, TAKAYAMA FUSAKO, MIO MITSUNOBU, KAWASAKI HIROMU

薬学雑誌 128 ( 3 ) 419 - 424 2008.3

光に不安定な薬剤の簡易懸濁法を用いた経管投与方法について

座間味義人, 槙田崇志, 安藤哲信, 倉田なおみ, 合葉哲也, 黒崎勇二, 北村佳久, 千堂年昭, 高山房子, 川崎博己, 五味田裕

日本薬学会年会要旨集 128年会 ( 4 ) 220 - 220 2008.3

食後高血糖時の急性高インスリン状態における交感神経機能亢進とAngiotensin II Type 1受容体の関与

座間味義人, 高取真吾, 宮下智子, 薮前奈々, 細田美穂, 岩谷有希子, 高山房子, 見尾光庸, 川崎博己

血管 31 ( 1 ) 38 - 38 2008.1

フルクトース負荷ラットにおける血管周囲神経分布異常のピオグリタゾンによる改善

網谷慶介, 座間味義人, 細田美穂, 合田光寛, 北村佳久, 川崎博己

日本薬理学会近畿部会プログラム・要旨集 114th 47 2008

Changes in mesenteric perivascular nerve function in fructose-drinking rats (FDR)

Nana Yabumae, Miho Hosoda, Yoshito Zamami, Hiroki Fujiwara, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 195P - 195P 2008

Role of redox action in abnormal neuronal regulation of vascular tone induced by acute hyperinsulinemia correspond to postprandial hyperglycemia

Yoshito Zamami, Shingo Takatori, Yukiko Iwatani, Xin Jin, Toshihiro Koyama, Yoshihisa Kitamura, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 128 ( 0 ) 70 - 72 2008

Language：Japanese Publisher：PHARMACEUTICAL SOC JAPAN

Transient postprandial hyperglycemia has been shown to contribute to the development of hypertension in patients with type 2 diabetes. Previously, we reported that acute hyperglycemia and hyperinsulinemia correspond to postprandial hyperglycemia elicits altered neuronal regulation of vascular tone, which partly contributes to the development of hypertension. However, the underlying mechanism remains unclear. In the present study, we investigated the role of redox action in abnormal neuronal regulation of vascular tone induced by acute hyperglycemia and hyperinsulinemia by measuring vascular responses to spinal cord stimulation and i.v. bolus injections of noradrenaline and CGRP in pithed rats, which have no vasoreflex. In pithed rats treated with octreotide, which increased blood glucose levels without increasing serum insulin levels, glucose infusion caused only significant augmentation of adrenergic nerve-mediated pressor responses, which was not affected by ascorbic acid infusion. Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemia, significantly augmented adrenergic nerve-mediated pressor response and reduced CGRPerglic nerve-mediated depressor response, which were ameliorated by ascorbic acid infusion. These findings suggest that redox action is involved in occurrence of altered neuronal regulation of vascular tone in acute hyperinsulinemic state.

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ラット腸間膜動脈におけるアゴニスト誘発収縮に対する内皮依存性抑制の特徴

金シン, 音無由紀子, 座間味義人, 孫鵬遠, 北村佳久, 川崎博己

日本薬理学会近畿部会プログラム・要旨集 113rd 45 2008

Effect of Propolis on Insulin Resistance in Fructose-drinking Rats

ZAMAMI Yoshito, TAKATORI Shingo, KOYAMA Toshihiro, GODA Mitsuhiro, IWATANI Yukiko, DOI Shima, KAWASAKI Hiromu

Journal of the Pharmaceutical Society of Japan 127 ( 12 ) 2065 - 2073 2007.12

Language：Japanese Publisher：公益社団法人日本薬学会

Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300mg/kg, p. o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.

DOI： 10.1248/yakushi.127.2065

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Effect of Long-term Treatment with Royal Jelly on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

NOMURA Masataka, MARUO Naomi, ZAMAMI Yoshito, TAKATORI Shingo, DOI Shima, KAWASAKI Hiromu

Journal of the Pharmaceutical Society of Japan 127 ( 11 ) 1877 - 1882 2007.11

Language：Japanese Publisher：公益社団法人日本薬学会

Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance.

DOI： 10.1248/yakushi.127.1877

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Acute hyperglycemia and hyperinsulinemia enhance adrenergic vasoconstriction and decrease calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats

ZAMAMI Yoshito, TAKATORI Shingo, YAMAWAKI Kousuke, MIYASHITA Satoko, YABUMAE Nana, TAKAYAMA Fusako, MIO Mitsunobu, KAWASAKI Hiromu

血管 30 ( 3 ) 81 - 86 2007.10

フルクトース負荷早期における血管反応性の変化

薮前奈々, 細田美穂, 座間味義人, 金きょう, 合田光寛, 小山敏広, 高取真吾, 高山房子, 川崎博己

日本薬理学雑誌 130 ( 3 ) 12P - 12P 2007.9

新しい薬効評価法を用いた治療薬の開発食後高血糖が血管反応性に及ぼす影響

座間味義人, 高取真吾, 山脇康佑, 宮下智子, 藪前奈々, 高山房子, 見尾光庸, 川崎博己

日本薬学会年会要旨集 127年会 ( 1 ) 291 - 291 2007.3

フルクトース負荷ラットのインスリン抵抗性に及ぼすプロポリス長期投与の影響

小山敏広, 土井志真, 高取真吾, 座間味義人, 合田光寛, 高山房子, 見尾光庸, 川崎博己

日本薬学会年会要旨集 127年会 ( 2 ) 133 - 133 2007.3

食後高血糖が血圧調節機構に及ぼす影響

座間味義人, 高取真吾, 山脇康佑, 宮下智子, 高山房子, 見尾光庸, 川崎博己

日本薬理学雑誌 129 ( 2 ) 32P - 32P 2007.2

食後高血糖を想定した急性高血糖状態における血管反応性の変化

座間味義人, 高取真吾, 山脇康佑, 宮下智子, 薮前奈々, 高山房子, 見尾光庸, 川崎博己

血管 30 ( 1 ) 27 - 27 2007.1

Effect of nitric-oxide synthase (NOS) inhibition on blood pressure response to spinal cord stimulation in pithed rats.

Kosuke Yamawaki, Satoshi Okuhata, Yoshito Zamami, Fusako Takayama, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 145P - 145P 2007

食後高血糖時の急性高インスリン状態におけるCGRP神経機能減弱とAngiotensin II Type 1受容体の関与

座間味義人, 高取真吾, 藪前奈々, 宮下智子, 細田美穂, 高山房子, 見尾光庸, 川崎博己

日本循環薬理学会口演要旨集 17th 42 2007

Histamine-induced cardiovascular responses in the pithed rat with a pretreatment of L-NAME

Shingo Takatori, Shinpei Takei, Yoshito Zamami, Hiromu Kawasaki, Mitsunobu Mio

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 146P - 146P 2007

Postprandial hyperglycemia influences neuronal regulation of blood pressure

座間味義人, 高取真吾, 山脇康佑

Journal of the Pharmaceutical Society of Japan 126 ( 0 ) 144 - 146 2006.9

食後高血糖が神経性血圧調節機能に及ぼす影響

座間味義人, 高取真吾, 山脇康佑, 宮下智子, 高山房子, 見尾光庸, 川崎博己

生体機能と創薬シンポジウム 2006 144 - 146 2006.9

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