Faculty Profiles - ZAMAMI Yoshito

MISC - ZAMAMI Yoshito

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土-P3-501 経管投与患者に対する安全な抗がん薬治療の推進に向けた簡易懸濁法の適応性評価(がん薬物療法(その他),ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)

天野学, 比知屋寛之, 大竹祐貴子, 東薫, 伴英里香, 筧幸子, 安智美, 清原義史, 座間味義人, 井上徹雄, 田中一穂, 木原零, 倉田なおみ, 森山雅弘, 駒田富佐夫

日本医療薬学会年会講演要旨集 23 335 - 335 2013.8

ECMO(膜型人工肺)回路の薬物吸着に影響する因子は何か?

飯田淳義, 市場晋吾, 林久美子, 武本あかね, 北村佳久, 千堂年昭, 座間味義人, 名倉弘哲, 松木範明, 氏家良人

日本救急医学会雑誌 24 ( 8 ) 570 - 570 2013.8

P2-109 地域連携に伴う薬剤感受性の変化 : 特定抗菌薬使用への介入の効果(感染制御(その他),ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)

畑中由香子, 藤田和也, 足立恵子, 北村直之, 座間味義人

日本医療薬学会年会講演要旨集 22 396 - 396 2012.10

血管周囲CGRP神経伝達に及ぼす5-hydroxytryptamine(5-HT)の影響

三宅夏樹, 藤井裕士, 高取真吾, 座間味義人, 川崎博巳

日本薬理学雑誌 139 ( 3 ) 25P - 25P 2012.3

[Insulin resistance-induced hypertension and perivascular nerves-an approach to elucidate the mechanisms involved].

Shingo Takatori, Yoshito Zamami, Narumi Hashikawa-Hobara, Hiromu Kawasaki

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 139 ( 2 ) 70 - 4 2012.2

Language：Japanese Publisher：The Japanese Pharmacological Society

インスリン抵抗性は，カロリーの摂取過剰，運動不足，肥満等が原因となり食後高血糖が継続することで，末梢組織におけるインスリンの糖取込み効果が得られにくくなった状態を示す．病態初期には，インスリン分泌が維持されているため，結果として血中のインスリン値が上昇して高インスリン血症を生じる．その後，膵臓&beta;細胞の疲弊の結果，インスリン分泌不全となり糖尿病へ進展するので，糖尿病の前段階の病態である．また，脂質異常症および高血圧の発症やそれらの進展に深く関与するほか，脳や心臓などに動脈硬化症を起こしやすくなることが明らかにされている．しかしながら，糖尿病に伴う高血圧についてはその発現機序が十分に明らかにされていない．そこで我々は，インスリン抵抗性により誘導される高血圧（インスリン抵抗性高血圧）の発症メカニズムの解明を目的として，血管周囲神経を介した血管調節機構に及ぼす高インスリン血症および高血糖の影響について検討を行い，（1）血管拡張性神経（カルシトニン遺伝子関連ペプチド，CGRP神経）の分布減少と機能低下，（2）交感神経の分布増加と機能亢進などのメカニズムを介して，高血圧の発症・進展に関与しているという新たな知見を得た．これらの研究成果は，インスリン抵抗性高血圧の病態解明に繋がるのみならず，インスリン抵抗性時に認められる神経リモデリング作用に基づいて神経因性疼痛などの神経変性疾患の治療薬開発など新しい研究分野の創出にも新たな知見をもたらし，社会的貢献は非常に大きいと考えられる．

DOI： 10.1254/fpj.139.70

P-0589 経腸栄養剤を用いた疎水性薬剤の簡易懸濁法適用の検討(一般演題ポスター発表,医薬品情報・データベース,Enjoy Pharmacists' Lifestyles)

座間味義人, 松永康臣, 合葉哲也, 天野学, 小山敏広, 四宮一昭, 北村佳久, 黒崎勇二, 佐々木健二, 野田真吾, 千堂年昭, 川崎博己, 五味田裕

日本医療薬学会年会講演要旨集 21 280 - 280 2011.9

Paracrine control of mesenteric perivascular axo-axonal interaction

H. Kawasaki, S. Takatori, Y. Zamami, T. Koyama, M. Goda, K. Hirai, P. Tangsucharit, X. Jin, N. Hobara, Y. Kitamura

ACTA PHYSIOLOGICA 203 ( 1 ) 3 - 11 2011.9

Language：English Publishing type：Book review, literature introduction, etc. Publisher：WILEY-BLACKWELL

Immunohistochemical study of rat mesenteric arteries showed dense innervation of adrenergic nerves, calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves), nitric oxide-containing nerves (nitrergic nerves). Double-immunostaining revealed that most CGRPergic or nitrergic nerves were in close contact with adrenergic nerves. CGRPergic and transient receptor potential vanilloid-1 (TRPV1)-immunopositive nerves appeared in the same neurone. In rat perfused mesenteric vascular beds without endothelium and with active tone, perfusion of nicotine, or bolus injection of capsaicin and acetylcholine and periarterial nerve stimulation (PNS) lowered pH levels of out flowed perfusate concomitant with vasodilation. Cold-storage denervation of preparations abolished pH lowering induced by nicotine and PNS. Guanethidine inhibited PNS- and nicotine-, but not acetylcholine-and capsaicin-, induced pH lowering. Pharmacological analysis showed that protons were released not only from adrenergic nerves but also from CGRPergic nerves. A study using a fluorescent pH indicator demonstrated that nicotine, acetylcholine and capsaicin applied outside small mesenteric artery lowered perivascular pH levels, which were not observed in Ca(2+) free medium. Exogenously injected hydrochloric acid in denuded preparations induced pH lowering and vasodilation, which was inhibited by denervation, TRPV1 antagonists and capsaicin without affecting pH lowering. These results suggest that excitement of adrenergic nerves releases protons to activate TRPV1 in CGRPergic nerves and thereby induce vasodilation. It is also suggested that CGRPergic nerves release protons with exocytosis to facilitate neurotransmission via a positive feedback mechanism. Keywords adrenergic nerves, axo-axonal transmitter, CGRPergic nerves, mesenteric artery, protons, TRPV1.

DOI： 10.1111/j.1748-1716.2010.02197.x

Otsuka Long‐Evans Tokushima Fatty(OLETF)ラットにおけるインスリン抵抗性と血管周囲神経分布異常に対する杜仲葉エキス(ELE)の影響

高取真吾, 座間味義人, 川崎博己, 細尾信悟, 平田哲也, 和田篤敬

日本杜仲研究会定期大会講演要旨集 6th 27 2011.7

インスリン抵抗性モデルラット摘出脂肪細胞におけるアディポサイトカイン放出に及ぼす杜仲葉エキスおよび杜仲葉成分の影響

座間味義人, 高取真吾, 金きん, 平田哲也, 細尾信悟, 和田篤敬, 佐々木健二, 川崎博己

日本杜仲研究会定期大会講演要旨集 6th 26 2011.7

疎水性薬剤に対する経腸栄養剤を用いた簡易懸濁法適用の検討

松永康臣, 座間味義人, 大西順子, 小山敏広, 四宮一昭, 高取真吾, 北村佳久, 佐々木健二, 川崎博己, 野田真吾

日本薬学会年会要旨集 131年会 ( 4 ) 258 - 258 2011.3

ラット摘出脂肪細胞における遊離脂肪酸の放出に及ぼす杜仲葉エキスおよび杜仲葉成分の影響

座間味義人, 橋川成美, 橋川直也, 金シン, 細尾信悟, 平田哲也, 和田篤敬, 高取真吾, 佐々木健二, 川崎博己

日本薬学会年会要旨集 131年会 ( 3 ) 202 - 202 2011.3

Otsuka Long-Evans Tokushima Fatty(OLETF)ラットにおけるインスリン抵抗性と血管周囲神経分布異常に対する杜仲葉エキス(ELE)の影響

高取真吾, 座間味義人, 平田哲也, 細尾信悟, 和田篤敬, 川崎博己

日本薬学会年会要旨集 131年会 ( 3 ) 162 - 162 2011.3

血管周囲神経における5-Hydroxytryptamine(5-HT)の動態と神経機能に及ぼす影響

高取真吾, 藤井裕士, 原直之, 座間味義人, 川崎博己

血管 34 ( 1 ) 60 - 60 2011.1

マウス下肢虚血モデルにおけるPhenol誘発血管周囲神経障害の影響

岩田久美子, 鳥越菜央, 合田光寛, 高取真吾, 座間味義人, 川崎博已

日本循環薬理学会口演要旨集 21st 46 2011

The inhibitory mechanisms of nerve growth factor (NGF) in mouse tumor growth

Shingo Takatori, Satoko Fukuhara, Mitsuhiro Goda, Narumi Hashikawa, Yoshito Zamami, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 74P - 74P 2011

Effect of angiotensin II type 2 receptors on NGF-mediated neurite outgrowth in apoE knockout mice

Narumi Hashikawa, Naoya Hashikawa, Chikao Yutani, Yoshito Zamami, Shingo Takatori, Mitsunobu Mio, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 69P - 69P 2011

Role of Angiontensin Receptors on Remodeling Perivascular Nerves

HOBARA NARUMI, GODA MITSUHIRO, HASHIKAWA NAOYA, JIN XIN, ZAMAMI YOSHITO, TAKATORI SHINGO, KAWASAKI HIROMU

薬学雑誌 130 ( 11 ) 1421 - 1425 2010.11

杜仲葉エキスによるインスリン抵抗性および血管周囲神経分布・機能異常の改善

高取真吾, 金きん, 座間味義人, 平田哲也, 細尾信悟, 和田篤敬, 川崎博己

日本杜仲研究会定期大会講演要旨集 5th 27 2010.7

Ameliorative Effect of Propolis on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

ZAMAMI YOSHITO, FUJIWARA HIROKI, HOSODA MIHO, HINO HAYATO, HIRAI KAZUHIRO, OKAMOTO KAZUAKI, JIN XIN, TAKATORI SHINGO, TAKAKI(DOI) SHIMA, KAWASAKI HIROMU

薬学雑誌 130 ( 6 ) 833 - 840 2010.6

Language：Japanese Publisher：日本薬学会

&nbsp;&nbsp;Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance.

DOI： 10.1248/yakushi.130.833

CiNii Article

J-GLOBAL

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Endothelial Modulation of Agonist-induced Vasoconstriction in Mesenteric Microcirculation

Xin Jin, Yukiko Otonashi-Satoh, Yoshito Zamami, Toshihiro Koyama, Pengyuan Sun, Yoshihisa Kitamura, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 130 ( 5 ) 723 - 728 2010.5

Language：English Publishing type：Book review, literature introduction, etc. Publisher：PHARMACEUTICAL SOC JAPAN

It is widely accepted that vascular endothelium regulates vasoconstriction via release of endothelium-derived relaxing factors (EDRF). The mesenteric circulation, which is the largest vascular bed, influences regulation of systemic blood pressure. However, the role of EDRF in the modulation of vascular tone in peripheral mesenteric circulation has not been extensively studied. Therefore, our recent studies investigated the role of the vascular endothelium in the regulation of methoxamine (alpha(1)-adrenoceptor agonist)-induced vasoconstriction and their age-related changes in rat mesenteric vascular beds. In mesenteric vascular beds with intact endothelium isolated from 8 week-old rats, the initial maximum vasoconstriction induced by continuous perfusion of methoxamine was time-dependently decreased during 3 hour-perfusion. Neither nitric oxide synthase inhibitor nor cyclooxygenase inhibitor altered this time-dependent reduction of methoxamine-induced vasoconstriction. Endothelium removal, K+-channel inhibitors and gap junction inhibitor significantly inhibited the time-dependent reduction of methoxamine-induced vasoconstriction. In the preparations with intact endothelium from 16 week-old rats, the time-dependent reduction of methoxamine-induced vasoconstriction disappeared. Furthermore, endothelium removal and treatment with cyclooxygenase inhibitor, thromboxane A(2) receptor antagonist or superoxide dismutase mimetic significantly reduced the methoxamine-induced vasoconstriction in the preparations from 16 week-old rats. These findings suggest that vascular endothelium acts to depress methoxamine-induced vasoconstriction by releasing endothelium-derived hyperpolarizing factor (EDHF), and dysfunction in this endothelial modulation develops with ageing.

DOI： 10.1248/yakushi.130.723

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