Faculty Profiles - SAWA Yoshihiko

写真a

SAWA Yoshihiko

Organization

Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor

Contact information

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Degree

(BLANK) ( Hokkaido University )

Research Interests

解剖学
免疫学
血管学
Anatomy
Immunology
Microcirculation

Research Areas

Life Science / Oral biological science

Education

Hokkaido University 歯学研究科歯学基礎系

- 1995

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Country： Japan

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Hokkaido University 歯学部歯学科

- 1991

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Country： Japan

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Research History

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Deparment of Oral Function & Anatomy Professor

2017.7

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福岡歯科大学歯学部（2013より口腔歯学部）教授（2011より講座主任、2016年よりアニマルセンター長）

2005.7 - 2017.6

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北海道大学大学院歯学研究科助教授

2004.4 - 2005.6

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北海道大学大学院歯学研究科助教授

2000.4 - 2004.3

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北海道大学歯学部助教授

2000.2 - 2000.3

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北海道大学歯学部講師

1999.4 - 2000.1

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エドワード・ハインズJr在郷軍人病院（シカゴ）文部省在外研究員（若手）

1998.10 - 1999.9

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北海道大学歯学部助手

1995.5 - 1999.3

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北海道大学歯学部研究生

1995.4 - 1995.5

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北大歯学部助手

1995 - 1999

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Professional Memberships

アメリカ臨床解剖学会

2009.6

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日本分子生物学会

2009.5

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日本癌学会

2009.5

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日本リンパ学会

1995.5

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日本微小循環学会（平成２０年より評議員）

1995.5

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International Association for Dental Research

1995.5

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歯科基礎医学会（平成１２年より評議員）

1995.5

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日本解剖学会（平成１２年より評議員）

1995.5

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Committee Memberships

日本学術振興会科学研究費委員会挑戦的研究部会第57小委員会II

2020

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日本学術振興会科学研究費委員会（医歯薬学III）専門委員・スタート支援

2017

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日本学術振興会科学研究費委員会（医歯薬学III）専門委員・スタート支援

2016

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日本学術振興会科学研究費委員会（医歯薬学III）専門委員・スタート支援

2014

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日本学術振興会科学研究費委員会（医歯薬学III）専門委員・スタート支援

2012

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Papers

Study of Podoplanin-Deficient Mouse Bone with Mechanical Stress. Reviewed International journal

Takenori Kanai, Kyoko Osawa, Koichiro Kajiwara, Yoshiaki Sato, Yoshihiko Sawa

Dentistry journal 13 ( 2 ) 2025.1

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Objective: We investigated morphological differences in osteocyte processes between aged mice and our original podoplanin-conditional knockout (cKO) mice in which the floxed exon 3 of podoplanin was deleted by Dmp-1-driven Cre (Dmp1-Cre;PdpnΔ/Δ). Methods: SEM observation on osteocyte cell process, histochemistry for bone remodeling with mechanostress, and RT-PCR for RANKL and M-CSF in podoplanin cKO mouse bone with mechanostress was investigated. Results: SEM observations showed fewer and thinner osteocyte processes in femurs from 23-week-old Dmp1-Cre;PdpnΔ/Δ mice than from 23-week-old wild-type mice, while the numbers of osteocyte processes in femurs and calvarias were similar in 23-week-old Dmp1-Cre;PdpnΔ/Δ mice and 48-week-old wild-type mice. Furthermore, cell process numbers in femurs and calvarias were significantly smaller in 23-week-old Dmp1-Cre;PdpnΔ/Δ mice than in 48-week-old wild-type mice. In the test for differences in alveolar bone resorption under mechanical stress between Dmp1-Cre;PdpnΔ/Δ and wild-type mice, the area of TRAP-positive resorption pits was larger in wild-type mice than in Dmp1-Cre;PdpnΔ/Δ mice. In a quantitative tissue PCR analysis, the mRNA expression levels of RANKL and M-CSF in alveolar bone under mechanical stress were significantly lower in Dmp1-Cre;PdpnΔ/Δ mice than in wild-type mice. These results suggest that a reduction in cell process formation in osteocytes with podoplanin cKO affected the absorption of alveolar bone under mechanical stress in Dmp1-Cre;PdpnΔ/Δ mice. Conclusions: In podoplanin-deficient bone, the deformation of osteocyte processes by mechanical stimuli is not recognized as a stress due to the lower number of cell processes with podoplanin deficiency; therefore, the production of osteoclast migration/differentiation factors by activated osteocytes is not fully induced and macrophage migration to alveolar bone with mechanical stress appeared to be suppressed. These results indicate that podoplanin-dependent osteocyte process formation indirectly plays a key role in sensing mechanical stress in bone.

DOI： 10.3390/dj13020061

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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells. Reviewed International journal

Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

BMC nephrology 26 ( 1 ) 38 - 38 2025.1

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Diabetes treatments by the control of sodium-glucose cotransporter 2 (SGLT2) is commonly conducted while there are still uncertainties about the mechanisms for the SGLT2 overexpression in kidneys with diabetes. Previously, we have reported that glomeruli and proximal tubules with diabetic nephropathy express toll-like receptor TLR2/4, and that the TLR ligand lipopolysaccharide (LPS) of periodontal pathogens have caused nephropathy in diabetic model mice. Recently, many researchers suggested that the periodontal pathogenic bacteria Fusobacterium (F.) nucleatum has the TLR4-associated strong activator of the colorectal inflammation and cancer. The present study aimed to investigate the possibility of F. nucleatum as an exacerbation factor of diabetes through the renal SGLT2 induction. METHODS: The induction of the SGLT2 by F. nucleatum LPS (Fn-LPS) were investigated in the streptozotocin-induced diabetic mouse renal tissue and cultured renal proximal epithelial cells. The changes of blood glucose levels and survival curves in diabetic mice with Fn-LPS were analyzed. The Fn-LPS-induced SGLT2 production in the diabetic mouse renal tissue and in the cultured proximal epithelial cells was examined by ELISA, quantitative RT-PCR, and immunohistochemical analysis. RESULTS: The SGLT2 expression in the cultured mouse tubular epithelial cells was significantly increased by TNF- or co-culture with Fn-LPS-supplemented J774.1 cells. The period to reach diabetic condition was significantly shorter in Fn-LPS-administered diabetic mice than in diabetic mice. All Fn-LPS-administered-diabetic mice reached humane endpoints during the healthy period of all of the mice administered Fn-LPS only. The promotion of the SGLT2 expression at the inner lumen of proximal tubules were stronger in the Fn-LPS-administered-diabetic mice than in diabetic mice. The renal tissue SGLT2 mRNA amounts and the number of renal proximal tubules with overexpressed SGLT2 in the lumen were more in the Fn-LPS-administered-diabetic mice than in diabetic mice. CONCLUSIONS: This study suggests that F. nucleatum causes the promotion of diabetes through the overexpression of SGLT2 in proximal tubules under the diabetic condition. Periodontitis with F. nucleatum may be a diabetic exacerbating factor.

DOI： 10.1186/s12882-025-03965-z

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The Abnormal Expression of Tubular SGLT2 and GULT2 in Diabetes Model Mice with Malocclusion-Induced Hyperglycemia. Reviewed International journal

Koichiro Kajiwara, Sachio Tamaoki, Yoshihiko Sawa

Biomedicines 13 ( 2 ) 2025.1

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Background: A relationship between malocclusion and the promotion of diabetes has been suggested. In hyperglycemia, the expression of sodium-glucose cotransporter 2 (SGLT2) and the facilitative glucose transporter 2 (GLUT2) is upregulated in proximal tubular cells, leading to an increase in renal glucose reabsorption. The present study aimed to investigate whether malocclusion contributes to diabetic exacerbation. Methods: Streptozotocin (STZ)-induced diabetic mice with malocclusion due to cutting molars were investigated based on increased blood glucose levels. PCR and immunohistochemical analyses were performed on diabetic mice kidneys to investigate the expression of SGLT2 and GLUT2. Results: Animal experiments were performed using 32 mice for 21 days. The time to reach a diabetic condition in STZ-administered mice was shorter with malocclusion than without malocclusion. The increase and mean blood glucose levels in STZ-administered mice were steeper and higher with malocclusion than without malocclusion. Urea albumin, BUN, and CRE levels were higher in diabetic mice with malocclusion than in diabetic mice without. Immunoreaction with anti-SGLT2 and anti-GLUT2 in the renal tissue of STZ-administered mice was stronger with malocclusion than without malocclusion. The amounts of SGLT2 and GLUT2 mRNA in the renal tissue in STZ-administered mice were higher with malocclusion than without malocclusion. The amounts of TNF-a and IL-6 mRNA in the large intestinal tissue in STZ-administered mice were higher with malocclusion than without malocclusion. Conclusions: Our results indicate that malocclusion accelerates the tubular expression of SGLT2 and GLUT2 under hyperglycemia. Malocclusion may be a diabetes-exacerbating factor with increased poor glycemic control due to shortened occlusion time resulting from swallowing food without chewing.

DOI： 10.3390/biomedicines13020267

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ポドプラニンノックアウトマウスにおける下顎前歯歯槽骨の骨リモデリング機構について

梶原弘一郎, 沢禎彦, 玉置幸雄

日本矯正歯科学会大会プログラム・抄録集 83回 187 - 187 2024.10

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Language：Japanese Publisher：(公社)日本矯正歯科学会

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Morphological Study for the Osteocytes in Podoplanin-Conditional Knockout Mice Reviewed

Kyoko Osawa, Takenori Kanai, Natsumi Ushijima, Koichiro Kajiwara, Yoshihiko Sawa, Yoshiaki Sato

Journal of Hard Tissue Biology 32 ( 4 ) 213 - 222 2023.10

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Authorship：Corresponding author Publishing type：Research paper (scientific journal) Publisher：Society for Hard Tissue Regenerative Biology

DOI： 10.2485/jhtb.32.213

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糖尿病マウス腎におけるSGLT2 and VCAM-1発現について

梶原弘一郎, 沢禎彦

Journal of Oral Biosciences Supplement 2023 [P3 - 05 2023.9

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Language：Japanese Publisher：(一社)歯科基礎医学会

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P.gingivalis LPS誘導性糖尿病モデルマウス腎でのSGLT2過剰発現について(Overexpression of SGLT2 in the kidney of a P.gingivalis LPS-induced diabetic nephropathy mouse model) Reviewed

梶原弘一郎, 沢禎彦

Journal of Oral Biosciences Supplement 2022 370 - 370 2022.9

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Authorship：Last author,　Corresponding author Language：Japanese Publisher：(一社)歯科基礎医学会

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Maxillofacial morphological characteristics in growing orthodontic patients with non‐syndromic oligodontia Reviewed

Taiki Suyama, Hiroyuki Ishikawa, Sachio Tamaoki, Remi Higa, Shunsuke Takata, Yoshihiko Sawa

Orthodontics & Craniofacial Research 2021.12

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Authorship：Last author Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1111/ocr.12548

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ocr.12548
Overexpression of SGLT2 in the kidney of a P. gingivalis LPS-induced diabetic nephropathy mouse model. Reviewed International journal

Koichiro Kajiwara, Yoshihiko Sawa

BMC Nephrology 22 ( 1 ) 287 - 287 2021.8

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The overexpression of sodium-glucose cotransporter 2 (SGLT2) in diabetic kidneys has been reported. It has also been established that the diabetic glomerular endothelium expresses the toll-like receptors TLR2 and TLR4. The present study aims to examine the renal SGLT2 induction by the TLR2/4 ligand Porphyromonas (P.) gingivalis lipopolysaccharide (Pg-LPS) in mouse diabetic nephropathy. METHODS: Immunohistochemical study and tissue RT-PCR analyses were performed on mouse kidneys in streptozotocin (STZ)-induced diabetic ICR mice (STZ-ICR), in healthy ICR mice administered Pg-LPS (LPS-ICR), and in diabetic ICR mouse kidneys with Pg-LPS-induced nephropathy (LPS-STZ). RESULTS: In the quantitative analysis of blood sugar levels, the mean time to reach 600 mg/dl was shorter in the LPS-STZ than in the STZ-ICR kidneys. The rise in blood glucose levels was significantly steeper in the LPS-STZ than in the STZ-ICR kidneys. According to these data the LPS-STZ model suggests a marked glucose intolerance. The expression of SGLT2 was significantly stronger in the whole of the renal parenchyma of the LPS-STZ than in the LPS-ICR or in the STZ-ICR. The expression of SGLT2 was observed both in the renal tubules and around the renal tubules, and in the glomeruli of the LPS-STZ kidneys. In the analysis by tissue real-time PCR and cell ELISA, the expression of the SGLT2 gene and protein was significantly stronger in the LPS-STZ than in the LPS-ICR or in the STZ-ICR. There were no differences in the renal SGLT2 production in the LPS-ICR and the STZ-ICR kidneys. CONCLUSIONS: Abnormally high renal expression of SGLT2 occurs in diabetic kidneys with P. gingivalis LPS. Periodontitis may be an exacerbating factor in diabetic nephropathy as well as in diabetes.

DOI： 10.1186/s12882-021-02506-8

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Expression of SARS-CoV-2 entry factors in human oral tissue. Reviewed International journal

Yoshihiko Sawa, Soichiro Ibaragi, Tatsuo Okui, Junro Yamashita, Tetsuro Ikebe, Hiroyuki Harada

Journal of Anatomy 238 ( 6 ) 1341 - 1354 2021.6

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The distribution of cells expressing SARS-CoV-2 entry factor angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in human oral tissues were tested. The investigation was conducted with normal flesh tissue and paraffin-embedded specimens. The ACE2 and TMPRSS2 expression was detected with all subjects in the normal mucosa of the keratinized stratified squamous epithelia of the tongue and non-keratinized stratified squamous epithelia of the lip and cheek. It was found that ACE2 is expressed in the cytoplasm and on the cell membrane mainly in the stratum granulosum of the epithelia while the TMPRSS2 is strongly expressed on the cell membrane mainly in the stratum granulosum and stratum spinosum, but not in the stratum basale. Antibodies' reactions for ACE2 and TMPRSS2 were not observed in the nuclei or keratin layer. The expression of ACE2 and TMPRSS2 in the oral epithelia appears to be general, and the expression was also observed in the mucous and serous acini of the labial glands. The SARS-CoV-2 may transiently attach to the oral mucosa and the minor salivary glands which are present under all of the oral mucosa. The oral cavity can be considered an important organ for SARS-CoV-2 attachment and may provide a preventive medical avenue to guard against COVID-19 by preventing saliva from scattering.

DOI： 10.1111/joa.13391

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Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy. Reviewed International journal

Koichiro Kajiwara, Yoshihiko Sawa, Takahiro Fujita, Sachio Tamaoki

BMC Nephrology 22 ( 1 ) 3 - 3 2021.1

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The present study aims to examine the expression of leukocyte adhesion molecules and renal metabolic factors in diabetic mouse kidneys with periodontal pathogen Pg-LPS-induced nephropathy. BACKGROUND: We recently reported that the glomerular endothelium expresses toll-like receptor (TLR)2 and TLR4 in diabetic environments and TLR2/4 ligand Porphyromonas (P.) gingivalis lipopolysaccharides (Pg-LPS) induce nephropathy in diabetic mice. It is thought that Pg-LPS promotes the chronic inflammation with the overexpression of leukocyte adhesion molecules and renal-specific metabolic enzymes by the recognition of Pg-LPS via TLR in the diabetic kidneys. There have been no reports of the effects of periodontopathic bacteria on the expression of leukocyte adhesion molecules and the accumulation of physiologically active substances in the kidney. METHODS: The immunohistochemical investigation was performed on diabetic mouse kidney with Pg-LPS-induced nephropathy with glomerulosclerosis in glomeruli. RESULTS: There were no vessels which expressed vascular cell adhesion molecule-1 (VCAM-1), E-selectin, or fibroblast growth factor (FGF) 23 in streptozotocin (STZ)-induced diabetic ICR mice (STZ-ICR), or in healthy ICR mice administered Pg-LPS (LPS-ICR). However, in diabetic ICR mouse kidneys with Pg-LPS-induced nephropathy (LPS-STZ) the expression of VCAM-1 and the accumulation of FGF23 were observed in renal tubules and glomeruli, and the expression of E-selectin was observed in renal parenchyma and glomeruli. The angiotensin-converting enzyme 2 (ACE2) was detected in the proximal tubules but not in other regions of ICR, STZ-ICR, or LPS-ICR. In LPS-STZ ACE2 was detected both in renal tubules as well as in glomeruli. The Mac-1 and podoplanin-positive cells increased in the renal parenchyma with diabetic condition and there was the distribution of a large number of Mac-1-positive cells in LPS-STZ. CONCLUSIONS: The Pg-LPS may induce diabetic renal inflammation such as glomerulosclerosis and tubulitis with infiltration of Mac-1/podoplanin positive macrophages via glomerular overexpression of VCAM-1 and E-selectin, resulting in accumulation of both ACE2 and FGF23 which were unmetabolized with the inflammation-induced kidney damage under the diabetic condition. Periodontitis may be a critical factor in the progress of nephropathy in diabetic patients.

DOI： 10.1186/s12882-020-02203-y

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Cancellation of the Calcification in Cultured Osteoblasts by CLEC-2

Takenori Kanai, Yoshihiko Sawa, Yoshiaki Sato

Journal of Hard Tissue Biology 30 ( 1 ) 53 - 62 2021

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Authorship：Corresponding author Publisher：Society for Hard Tissue Regenerative Biology

DOI： 10.2485/jhtb.30.53

J-GLOBAL

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Effect of bisphosphonates on healing of tooth extraction wounds in infectious osteomyelitis of the jaw Reviewed International journal

Junro Yamashita, Naruhiko Sawa, Yoshihiko Sawa, Shoji Miyazono

Bone 143 115611 - 115611 2020.8

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

OBJECTIVES: Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) and infectious osteomyelitis of the jaw (OMJ) in antiresorptive-naïve patients are different disease entities. Although osteoclast inhibition is at the center of the pathogenesis of ARONJ, the role of osteoclast inhibition in infectious OMJ is unknown. The objective of this study was to determine the effect of bisphosphonate osteoclast inhibition in infectious OMJ. METHODS: Osteomyelitis was induced in mice by S. aureus inoculation. The establishment of OMJ was verified by the culture of bone marrow samples obtained from the mandible. Infected animals received either zoledronic acid (ZA) or saline starting at week-2. Treated animals along with non-infected animals underwent tooth extractions at week-4 post-infection. Healing was assessed every week using in vivo micro-computed tomography and intraoral photos. Animals were euthanized at week-8 and cervical lymph nodes were assessed for lymphatic and blood vessels. RESULTS: Tooth extraction wounds did not heal in animals with OMJ. These wounds were characterized by incomplete soft tissue coverage, sporadic bone fill in the sockets, and inflammatory cell accumulation in the connective tissue at 4 weeks after tooth extractions. Conversely, the majority of tooth extraction wounds in the infected animals treated with ZA had improved healing with better bone fill than even non-infected control animals. Consistently, atrophic lymphatic vessels were noted in the draining lymph nodes in animals with OMJ. However, infected animals treated with ZA had lymphatic vessels that were unaltered and showed a similar appearance to those in non-infected control animals. CONCLUSION: ZA treatment promoted wound healing in the jaw with infectious osteomyelitis. Clearly, antiresorptive therapy is contraindicated in patients with ARONJ. However, our finding suggests that osteoclast inhibition is potentially an effectual remedy for infectious OMJ in antiresorptive-naïve patients.

DOI： 10.1016/j.bone.2020.115611

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Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes. International journal

Naruhiko Sawa, Hiroki Fujimoto, Yoshihiko Sawa, Junro Yamashita

Scientific reports 9 ( 1 ) 13842 - 13842 2019.9

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Language：English Publishing type：Research paper (scientific journal)

Osteocytes are terminally differentiated osteoblasts embedded in the bone matrix. Evidence indicates that cells in the mesenchymal lineage possess plasticity. However, whether or not osteocytes have the capacity to dedifferentiate back into osteoblasts is unclear. This study aimed to clarify the dedifferentiation potential of osteocytes. Mouse calvarial osteoblasts were isolated and maintained in normal two-dimensional (2D) or collagen gel three-dimensional (3D) cultures. In 2D cultures, osteoblasts exhibited a typical fibroblast-like shape with high Alpl and minimal Sost, Fgf23, and Dmp1 expression and osteoblasts formed mineralised nodules. When these osteoblasts were transferred into 3D cultures, they showed a stellate shape with diminished cytoplasm and numerous long processes and expression of Alpl decreased while Sost, Fgf23, and Dmp1 were significantly increased. These cells were in cell cycle arrest and showed suppressed mineralisation, indicating that they were osteocytes. When these osteocytes were recovered from 3D cultures and cultured two-dimensionally again, they regained adequate cytoplasm and lost the long processes, resulting in a fibroblast-like shape. These cells showed high Alpl and low Sost, Fgf23, and Dmp1 expression with a high mineralisation capability, indicating that they were osteoblasts. This report shows that osteocytes possess the capacity to dedifferentiate back into mature osteoblasts without gene manipulation.

DOI： 10.1038/s41598-019-50236-7

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Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes Reviewed International journal

Sawa N, Fujimoto H, Sawa Y, Yamashita J

Scientific Reports 25;9 ( 1 ) 13842 - 21788 2019.9

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Language：English Publishing type：Research paper (scientific journal)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

DOI： 10.1038/s41598-020-78856-4

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Maxillofacial morphological factors related to acceleration of maxillary growth attributed to facial mask treatment: a structural superimposition study. Reviewed International journal

Takashi S Kajii, Yui Sakaguchi, Yoshihiko Sawa, Sachio Tamaoki

Progress in orthodontics 20 ( 1 ) 2 - 2 2019.1

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Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Anatomical textbooks mention that the contact between the pterygoid process and the palatine's pyramidal process is not a "suture" but "conjugation.".The aim was to evaluate the maxillofacial morphological factor responding most to the orthopedic force of facial mask treatment, using the structural superimposition analysis. METHODS: Thirty-one girls with Angle Class III malocclusion treated using a facial mask (FM group) and 11 girls with pseudo-Class III malocclusion (pseudo-III group) were examined. Lateral cephalograms at pre- and posttreatment were analyzed to evaluate maxillofacial changes. Cephalometric structural superimposition analysis originating with Björk and Skieller was also performed. RESULTS: In the FM group, a multiple linear regression model showed that maxillary sutural growth was significantly associated with counter-clockwise rotation of the maxilla and treatment changes in the anteroposterior distance from the pterygomaxillary fissure to the maxillary anterior alveolus, not changes in the distance from the nasion to the maxillary anterior alveolus. CONCLUSIONS: Structural superimposition analysis showed that counter-clockwise rotation of the maxilla and changes in the distance from the pterygomaxillary fissure to the maxillary anterior alveolus responded most to the orthopedic force of facial mask treatment. The analysis implicated that the pterygoid fissure-palatine's pyramidal process conjugation responds most to facial mask treatment among maxillofacial sutures and conjugation, and that the difference in the response induces maxillary counter-clockwise rotation.

DOI： 10.1186/s40510-018-0254-9

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LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer Reviewed International journal

Akihiro Miyazaki, Hiromi Nakai, Tomoko Sonoda, Yoshihiko Hirohashi, Mika K. Kaneko, Yukinari Kato, Yoshihiko Sawa, Hiroyoshi Hiratsuka

Oncotarget 9 ( 30 ) 21156 - 21165 2018.4

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Impact Journals LLC

DOI： 10.18632/oncotarget.24986

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Expression and dynamics of podoplanin in cultured osteoblasts with mechanostress and mineralization stimulus Reviewed

Tomohiro Takenawa, Takenori Kanai, Tetsuya Kitamura, Yoshitaka Yoshimura, Yoshihiko Sawa, Junichiro Iida

Acta Histochemica et Cytochemica 51 ( 1 ) 41 - 52 2018

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Society of Histochemistry and Cytochemistry

DOI： 10.1267/ahc.17031

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The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors Reviewed International journal

Koichiro Kajiwara, Shunsuke Takata, Thao T. To, Kenyo Takara, Yuji Hatakeyama, Sachio Tamaoki, Richard Peters Darveau, Hiroyuki Ishikawa, Yoshihiko Sawa

Diabetology and Metabolic Syndrome 9 ( 1 ) 73 - 73 2017.9

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：BioMed Central Ltd.

DOI： 10.1186/s13098-017-0271-8

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Distinct Role of Transforming Growth Factor-Beta 1 and Fibroblast Growth Factors in Human Amelobastoma Epithelial Cell Proliferation

Yuko Matsuda, Naoko Kamogashira, Yuji Hatakeyama, Toshinari Mikami, Kazuki Nakashima, Junko Hatakeyama, Sachio Tamaoki, Yoshihiko Sawa, Hiroyuki Ishikawa

Biochemistry and Molecular Biology 2 ( 1 ) 1 - 5 2017.9

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Language：English Publishing type：Research paper (scientific journal) Publisher：Science Publishing Group

DOI： 10.11648/j.bmb.20170201.11

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Morphological study of tooth development in podoplanin-deficient mice Reviewed International journal

Kenyo Takara, Naoki Maruo, Kyoko Oka, Chiaki Kaji, Yuji Hatakeyama, Naruhiko Sawa, Yukinari Kato, Junro Yamashita, Hiroshi Kojima, Yoshihiko Sawa

PLOS ONE 12 ( 2 ) e0171912 2017.2

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0171912

Web of Science

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Effects of a chemically synthesized leucine-rich amelogenin peptide (csLRAP) on chondrogenic and osteogenic cells Reviewed

Yuko Matsuda, Yuji Hatakeyama, Kazuki Nakashima, Naoko Kamogashira, Junko Hatakeyama, Sachio Tamaoki, Yoshihiko Sawa, Hiroyuki Ishikawa

Journal of Hard Tissue Biology 26 ( 1 ) 51 - 60 2017

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Language：English Publishing type：Research paper (scientific journal) Publisher：Society of Hard Tissue Regenerative Biology

DOI： 10.2485/jhtb.26.51

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レクチンを用いた歯根膜におけるオキシタラン線維の検出の検討

鴨頭奈央子, 藤田隆寛, 中島一記, 松田裕子, 畠山雄次, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 42 ( 増補 ) 38 - 38 2016.12

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Language：Japanese Publisher：福岡歯科大学学会

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化学合成により作製されたLRAPの骨芽細胞分化に与える影響

松田裕子, 畠山雄次, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 42 ( 増補 ) 35 - 35 2016.12

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Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin. Reviewed International journal

Yukinari Kato, Satoshi Ogasawara, Hiroharu Oki, Ryusuke Honma, Michiaki Takagi, Yuki Fujii, Takuro Nakamura, Noriko Saidoh, Hazuki Kanno, Mitsuo Umetsu, Satoshi Kamata, Hiroshi Kubo, Mitsuhiro Yamada, Yoshihiko Sawa, Kei-Ichi Morita, Hiroyuki Harada, Hiroyoshi Suzuki, Mika Kato Kaneko

Monoclonal antibodies in immunodiagnosis and immunotherapy 35 ( 2 ) 109 - 16 2016.4

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Podoplanin (PDPN) is a type-I transmembrane sialoglycoprotein, which possesses a platelet aggregation-stimulating (PLAG) domain in its N-terminus. Among the three PLAG domains, O-glycan on Thr52 of PLAG3 is critical for the binding with C-type lectin-like receptor-2 (CLEC-2) and is essential for platelet-aggregating activity of PDPN. Although many anti-PDPN monoclonal antibodies (mAbs) have been established, almost all mAbs bind to PLAG domains. We recently established CasMab technology to produce mAbs against membranous proteins. Using CasMab technology, we produced a novel anti-PDPN mAb, LpMab-17, which binds to non-PLAG domains. LpMab-17 clearly detected endogenous PDPN of cancer cells and normal cells in Western-blot, flow cytometry, and immunohistochemistry. LpMab-17 recognized glycan-deficient PDPN in flow cytometry, indicating that the interaction between LpMab-17 and PDPN is independent of its glycosylation. The minimum epitope of LpMab-17 was identified as Gly77-Asp82 of PDPN using enzyme-linked immunosorbent assay. Of interest, LpMab-17 did not bind to monkey PDPN, whereas the homology is 94% between human PDPN and monkey PDPN, indicating that the epitope of LpMab-17 is unique compared with the other anti-PDPN mAbs. The combination of different epitope-possessing mAbs could be advantageous for the PDPN-targeting diagnosis or therapy.

DOI： 10.1089/mab.2015.0077

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Differentiation of Apical Bud Cells in a Newly Developed Apical Bud Transplantation Model Using GFP Transgenic Mice as Donor. Reviewed International journal

Naoki Maruo, Ryuji Sakagami, Yasunori Yoshinaga, Kazuhiko Okamura, Yoshihiko Sawa

PLoS one 11 ( 3 ) e0150766 2016

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Rodent mandibular incisors have a unique anatomical structure that allows teeth to grow throughout the lifetime of the rodent. This report presents a novel transplantation technique for studying the apical bud differentiation of rodent mandibular incisors. Incisal apical end tissue with green fluorescent protein from transgenic mouse was transplanted to wild type mice, and the development of the transplanted cells were immunohistologically observed for 12 weeks after the transplantation. Results indicate that the green fluorescent apical end tissue replaced the original tissue, and cells from the apical bud differentiated and extended toward the incisal edge direction. The immunostaining with podoplanin also showed that the characteristics of the green fluorescent tissue were identical to those of the original. The green fluorescent cells were only found in the labial side of the incisor up to 4 weeks. After 12 weeks, however, they were also found in the lingual side. Here the green fluorescent cementocyte-like cells were only present in the cementum close to the dentin surface. This study suggests that some of the cells that form the cellular cementum come from the apical tissue including the apical bud in rodent incisors.

DOI： 10.1371/journal.pone.0150766

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Intracellular Signaling Pathway Activation via TGF-β Differs in the Anterior and Posterior Axis During Palatal Development

Higa Arisa, Oka Kyoko, Kira-Tatsuoka Michiko, Tamura Shougo, Itaya Satoshi, Toda Masako, Ozaki Masao, Sawa Yoshihiko

Journal of Hard Tissue Biology 25 ( 2 ) 195 - 204 2016

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Language：English Publisher：THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

It is important to understand the different mechanisms involved in anterior hard and posterior soft palate development to prevent and treat patients with cleft palate. Genetic analyses of humans and gene-mutated mice with cleft palate have shown that TGF-β signaling has a critical role in palatogenesis. However, the intracellular signaling pathway of TGF-β during palatogenesis in the anterior-posterior axis has not yet been fully understood. In the present study, the expression patterns of intracellular molecules Smad2/3 and phospho-p38 (Pp38) were examined at embryonic days 13.5, 14.0, and 14.5 (E13.5, E14.0, and E14.5) in mice. It was found that Smad3 was activated in anterior palatal mesenchyme and in the medial edge epithelium (MEE) region, with TGF-β3 expressed at E13.5. On the other hand, Pp38 was more expressed in posterior palatal mesenchyme and strongly expressed in the entire palatal epithelium at E13.5. These opposing expression patterns between Smad3 and Pp38 in palatal mesenchyme were also observed at E14.0. Interestingly, Pp38 expression was inhibited in MEE from E14.0. Generally, from E14.5, the tissue specificities of hard and soft palate started showing their characteristics following the activation of cell differentiation in palatal mesenchyme, and the medial edge seam (MES) of the palatal epithelium started to disappear for fusion to occur. At this stage, Smad3 was also more expressed in anterior palatal mesenchyme, while expression of Pp38 was activated in posterior palatal mesenchyme. Pp38 expression was inhibited, but Smad3 was activated in the MES. These results suggest that TGF-β signaling plays various roles, such as in cell proliferation and differentiation of palatal mesenchyme and in the disappearance of the MES, through different intracellular signaling pathways in anterior-posterior palatal mesenchyme and epithelium.

DOI： 10.2485/jhtb.25.195

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Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development Reviewed

M. Kira-Tatsuoka, K. Oka, E. Tsuruga, M. Ozaki, Y. Sawa

Journal of Periodontal Research 50 ( 6 ) 714 - 720 2015.12

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DOI： 10.1111/jre.12256

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Intermittent Administration of Parathyroid Hormone Ameliorates Periapical Lesions in Mice Reviewed International journal

Masato Otawa, Ryuichiro Tanoue, Hirofumi Kido, Yoshihiko Sawa, Junro Yamashita

JOURNAL OF ENDODONTICS 41 ( 5 ) 646 - 651 2015.5

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DOI： 10.1016/j.joen.2014.12.008

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歯周病原菌由来LPSによるTLRを介した糖尿病性腎症の促進について

高田俊輔, 梶原弘一郎, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 40 ( 増補 ) 31 - 31 2014.12

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01332&link_issn=&doc_id=20150831220016&doc_link_id=%2Fcc3fkode%2F2014%2F0040s1%2F016%2F0031-0031%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcc3fkode%2F2014%2F0040s1%2F016%2F0031-0031%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
ヒト無色素毛様体上皮細胞およびヒト歯根膜線維芽細胞におけるオキシタラン線維の分解過程

川越慈, 敦賀英知, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 40 ( 増補 ) 36 - 36 2014.12

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マウス下顎切歯歯胚の幹細胞におけるSox2およびOct4の発現 Reviewed

丸尾直樹, 岡村和彦, 沢禎彦, 坂上竜資

Journal of Oral Biosciences Supplement 2014 160 - 160 2014.9

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Language：Japanese Publisher：(一社)歯科基礎医学会

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Immunohistochemical Study of Amelogenin and Lysosome-Associate Membrane Proteins (LAMPs) in Cartilage Reviewed

Yuji Hatakeyama, Junko Hatakeyama, Kyoko Oka, Eichi Tsuruga, Tetsuichiro Inai, Hisashi Anan, Yoshihiko Sawa

INTERNATIONAL JOURNAL OF MORPHOLOGY 32 ( 2 ) 618 - 626 2014.6

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Expression of Toll-Like Receptor 2 in Glomerular Endothelial Cells and Promotion of Diabetic Nephropathy by Porphyromonas gingivalis Lipopolysaccharide Reviewed International journal

Yoshihiko Sawa, Shunsuke Takata, Yuji Hatakeyama, Hiroyuki Ishikawa, Eichi Tsuruga

PLOS ONE 9 ( 5 ) e97165 2014.5

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DOI： 10.1371/journal.pone.0097165

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Microfibril-associated glycoprotein-1 controls human ciliary zonule development in vitro. Reviewed

Takahiro Fujita, Eichi Tsuruga, Kaori Yamanouchi, Yoshihiko Sawa, Hiroyuki Ishikawa

Acta histochemica et cytochemica 47 ( 1 ) 11 - 7 2014.2

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The ciliary zonule in the eye, also known as Zinn's zonule, is composed of oxytalan fibers, which are bundles of microfibrils consisting mainly of fibrillin-1. However, it is still unclear which of the microfibril-associated molecules present in the ciliary zonule controls oxytalan fibers. Microfibril-associated glycoprotein-1 (MAGP-1) is the only microfibril-associated molecule identified in the human ciliary zonule. In the present study, we used siRNA against MAGP-1 in cultures of human non-pigmented ciliary epithelial cells to examine the extracellular deposition and appearance of fibrillin-1 employing Western blotting and immunofluorescence. MAGP-1 suppression led to a reduction of fibrillin-1 deposition. Immunofluorescence also confirmed that RNAi-mediated down-regulation of MAGP-1 led to suppression of fiber development. These results suggest that MAGP-1 plays a crucial role in the extracellular deposition of fibrillin-1 during formation of the human ciliary zonule.

DOI： 10.1267/ahc.13038

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Distribution of podoplanin-expressing cells in the mouse nervous systems. Reviewed

Miwa Tomooka, Chiaki Kaji, Hiroshi Kojima, Yoshihiko Sawa

Acta histochemica et cytochemica 46 ( 6 ) 171 - 7 2013.12

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Podoplanin is a mucin-type glycoprotein which was first identified in podocytes. Recently, podoplanin has been successively reported as a marker for brain and peripheral nerve tumors, however, the distribution of podoplanin-expressing cells in normal nerves has not been fully investigated. This study aims to examine the podoplanin-expressing cell distribution in the mouse head and nervous systems. An immunohistochemical study showed that the podoplanin-positive areas in the mouse peripheral nerve and spinal cord are perineurial fibroblasts, satellite cells in the dorsal root ganglion, glia cells in the ventral and dorsal horns, and schwann cells in the ventral and dorsal roots; in the cranial meninges the dura mater, arachnoid, and pia mater; in the eye the optic nerve, retinal pigment epithelium, chorioidea, sclera, iris, lens epithelium, corneal epithelium, and conjunctival epithelium. In the mouse brain choroid plexus and ependyma were podoplanin-positive, and there were podoplanin-expressing brain parenchymal cells in the nuclei and cortex. The podoplanin-expressing cells were astrocyte marker GFAP-positive and there were no differences in the double positive cell distribution of several portions in the brain parenchyma except for the fornix. The results suggest that podoplanin may play a common role in nervous system support cells and eye constituents.

DOI： 10.1267/ahc.13035

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Leucine Rich Amelogenin Peptideによる軟骨形成の誘導

畠山純子, 畠山雄次, 松本典祥, 春名千英子, 諸冨孝彦, 泉利雄, 沢禎彦, 笹野泰之, 阿南壽

日本歯科保存学雑誌 56 ( 6 ) 560 - 569 2013.12

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歯の発生におけるLecin rich Amelogenin peptideの発現解析

畠山純子, 畠山雄次, 松本典祥, 春名千英子, 諸富孝彦, 泉利雄, 沢禎彦, 阿南壽

福岡歯科大学学会雑誌 39 ( 増補 ) 36 - 36 2013.12

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I型とII型糖尿病モデルマウスにおける腎リンパ管新生について

内山貴誠, 高田俊輔, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 39 ( 増補 ) 28 - 28 2013.12

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糖尿病モデルマウス腎糸球体におけるTLR2とTLR4の発現

高田俊輔, 内山貴誠, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 39 ( 増補 ) 36 - 36 2013.12

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Quantitative evaluation of myofibroblast apoptosis during wound healing in rat palate after post-operative administration of basic fibroblast growth factor (bFGF). International journal

Yuichiro Hata, Hiroyuki Ishikawa, Takeshi Ueki, Takashi S Kajii, Sachio Tamaoki, Eichi Tsuruga, Yoshihiko Sawa, Kunihisa Taniguchi

Acta odontologica Scandinavica 71 ( 6 ) 1501 - 7 2013.11

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OBJECTIVE: Excessive wound contraction apparently inhibits maxillary growth; thus, myofibroblast apoptosis needs to be accelerated in mucoperiosteal denudation after palatoplasty. The aim of this study was to evaluate myofibroblast apoptosis during wound healing in mucoperiosteal denudation of rat palates immediately after post-operative administration of basic fibroblast growth factor (bFGF). MATERIALS AND METHODS: A total of 100 male Wistar rats aged 20 days were divided into control, scar, sham and bFGF groups (n = 25 each). In the scar, sham and bFGF groups, mucoperiosteum was removed from the palate and fibrin glue was applied to the exposed bone surface immediately after surgery. In the bFGF group, 10 μL of 2 μg/μL bFGF solution was injected into the operated area beneath the fibrin glue. At 2, 5, 7, 14 and 28 days post-operatively, myofibroblast apoptosis during the wound healing process was investigated by double immunofluorescence staining. The apoptotic area of myofibroblasts was measured using image software. RESULTS: In the bFGF group, at 2 days, apoptosis of myofibroblasts in the lamina propria and submucosa was marked, as compared with the other three groups and apoptosis of myofibroblasts was scarcely seen at 5 days. At 5 and 7 days, the apoptotic area of myofibroblasts in the bFGF group was statistically significantly smaller when compared to the scar and sham groups. CONCLUSION: The results confirmed that bFGF injection immediately after surgery accelerated apoptosis of myofibroblasts in mucoperiosteal denudation of rats. This may reduce maxillary growth retardation due to excessive wound contraction.

DOI： 10.3109/00016357.2013.773370

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Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.

Takanobu Uchiyama, Shunsuke Takata, Hiroyuki Ishikawa, Yoshihiko Sawa

Acta histochemica et cytochemica 46 ( 2 ) 97 - 104 2013.4

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The dynamics of the renal lymphatic circulation in diabetic nephropathy is not fully elucidated. The present study evaluated the effect of diabetic nephropathy on the renal lymphatic circulation in streptozotocin (STZ)-induced type 1 diabetic mice (ICR-STZ) and in type 2 diabetic KK/Ta mice which were fed a high fat diet (KK/Ta-HF). The diabetic mouse kidneys developed edema because of the nephropathy. In control mice renal lymphatic vessels distributed in the cortex but rarely in the medulla while in ICR-STZ and KK/Ta-HF mice, there were many lymphatic vessels with small lumen in both cortex and medulla. Total numbers and areas of renal blood vessels in the diabetic mice were similar to those in the controls while the total numbers and areas of renal lymphatic vessels were larger in diabetic mice than in the controls. There were statistically significant differences in the numbers of lymphatic vessels with diameters of 50-100 µm between the ICR-STZ and the control ICR mice, and in the numbers of lymphatic capillaries with diameters smaller than 50 µm between the KK/Ta-HF and the control KK/Ta mice. The diabetic nephropathy may induce the lymphangiogenesis or result in at least the renal lymphatic vessel expansion.

DOI： 10.1267/ahc.13006

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Immunohistochemical Study of Lysosome-Associated Membrane Proteins During Periodontal Ligament Development Reviewed

Yuji Hatakeyama, Junko Hatakeyama, Kyoko Oka, Eichi Tsuruga, Tetsuichiro Inai, Yoshihiko Sawa

JOURNAL OF HARD TISSUE BIOLOGY 22 ( 2 ) 233 - 239 2013.4

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Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes. International journal

Hideki Fujii, Naoki Ohnishi, Kazuho Shimura, Masafumi Sakamoto, Tohru Ohkawara, Yoshihiko Sawa, Koichi Nishida, Yasuo Ohkawara, Tatsuro Kobata, Kanji Yamaguchi, Yoshito Itoh

World journal of gastroenterology 19 ( 11 ) 1834 - 40 2013.3

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Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology. The disease is characterized histologically by interface hepatitis, biochemically by increased aspartate aminotransferase and alanine aminotransferase levels, and serologically by increased autoantibodies and immunoglobulin G levels. Here we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes (HLLNs, diameter, 50 mm). Based on these observations, the differential diagnoses were AIH, lymphoma, or Castleman's disease. Liver biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute AIH. Lymph node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration; immunohistochemical examination excluded the presence of lymphoma cells. Thereafter, he was administered corticosteroid therapy: after 2 mo, the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in size. We could not find AIH cases with such enlarged lymph nodes (diameter, 50 mm) in our literature review. Hence, we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated, humoral immune response in AIH.

DOI： 10.3748/wjg.v19.i11.1834

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Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.

Shunsuke Takata, Yoshihiko Sawa, Takanobu Uchiyama, Hiroyuki Ishikawa

Acta histochemica et cytochemica 46 ( 1 ) 35 - 42 2013.2

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Diabetic conditions promote glomerulosclerosis by mesangial cells but the mechanisms are not fully elucidated. The present study evaluated the expression of toll-like receptor 4 in glomerular endothelial cells in the streptozotocin (STZ)-induced type 1 diabetic mouse (ICR-STZ) and the type 2 diabetic KK/TaJcl mouse which were fed a high fat diet feed (KK/Ta-HF). In the ICR-STZ and KK/Ta-HF almost glomeruli were immunostained with anti-TLR4 but there was no glomerulus immunostained by ani-TLR4 in the control ICR and KK/Ta. Laser-scanning confocal microscopy showed that the TLR4-positive region did not coincide with the podoplanin-positive region but coincide with the PECAM-1- and VE-cadherin-positive regions in the glomeruli of the ICR-STZ and KK/Ta-HF. The in situ hybridization showed that almost signals for TLR4 mRNA were present in the glomerulus of the ICR-STZ and KK/Ta-HF to a stronger extent than in the control ICR and KK/Ta. These suggest that glomerular endothelial cells usually express the TLR4 gene and hyperglycemia in the diabetic condition induces the TLR4 protein expression in the glomerular capillary endothelial cells. Cytokine productions through the TLR signaling pathway in glomerular endothelial cells may allow mesangial cells to produce extracellular matrix proteins in the diabetic milieu.

DOI： 10.1267/ahc.13002

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Matrix Metalloproteinase-2 Degrades Fibrillin-1 and Fibrillin-2 of Oxytalan Fibers in the Human Eye and Periodontal Ligaments In Vitro Reviewed

Megumi Kawagoe, Eichi Tsuruga, Kyoko Oka, Yoshihiko Sawa, Hiroyuki Ishikawa

ACTA HISTOCHEMICA ET CYTOCHEMICA 46 ( 5 ) 153 - 159 2013

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DOI： 10.1267/ahc.13024

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Cellular turnover in epithelial rests of Malassez in the periodontal ligament of the mouse molar Reviewed International journal

Kyoko Oka, Masakazu Morokuma, Kyoko Imanaka-Yoshida, Yoshihiko Sawa, Keitaro Isokawa, Masaki J Honda

European Journal of Oral Sciences 120 ( 6 ) 484 - 494 2012.12

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DOI： 10.1111/eos.12003

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Latent transforming growth factor-β binding protein 2 negatively regulates coalescence of oxytalan fibers induced by stretching stress Reviewed International journal

Eichi Tsuruga, Kyoko Oka, Yuji Hatakeyama, Keitaro Isokawa, Yoshihiko Sawa

Connective Tissue Research 53 ( 6 ) 521 - 527 2012.12

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DOI： 10.3109/03008207.2012.702816

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Chimeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity Reviewed International journal

Mika Kato Kaneko, Akiko Kunita, Shinji Abe, Yuta Tsujimoto, Masashi Fukayama, Kaoru Goto, Yoshihiko Sawa, Yasuhiko Nishioka, Yukinari Kato

Cancer Science 103 ( 11 ) 1913 - 1919 2012.11

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DOI： 10.1111/j.1349-7006.2012.02385.x

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歯周組織においてFibulin-4はLOXL2/エラスチン複合体形成を調節する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 38 ( 増補 ) 37 - 37 2012.11

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小児癌の抗癌剤治療が引き起こす永久歯の形成障害について

西村紗和, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 38 ( 増補 ) 29 - 29 2012.11

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Intracellular interaction of EMILIN-1 with fibrillin-1 in human periodontal ligament cells Reviewed

Yuka Nakatomi, Eichi Tsuruga, Yoshinori Yamauchi, Megumi Kawagoe, Kaori Yamanouchi, Kazuki Nakashima, Yoshihiko Sawa, Hiroyuki Ishikawa

Orthodontic Waves 71 ( 2 ) 66 - 69 2012.6

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DOI： 10.1016/j.odw.2012.01.002

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The expression of podoplanin and classic cadherins in the mouse brain Reviewed International journal

Chiaki Kaji, Miwa Tomooka, Yukinari Kato, Hiroshi Kojima, Yoshihiko Sawa

Journal of Anatomy 220 ( 5 ) 435 - 446 2012.5

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DOI： 10.1111/j.1469-7580.2012.01484.x

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Factors associated with the overall survival of elderly patients with hepatocellular carcinoma. International journal

Hideki Fujii, Yoshito Itoh, Naoki Ohnishi, Masafumi Sakamoto, Tohru Ohkawara, Yoshihiko Sawa, Koichi Nishida, Yasuo Ohkawara, Kanji Yamaguchi, Masahito Minami, Takeshi Okanoue

World journal of gastroenterology 18 ( 16 ) 1926 - 32 2012.4

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AIM: To identify the factors associated with overall survival of elderly patients with hepatocellular carcinoma (HCC). METHODS: A total of 286 patients with HCC (male/female: 178/108, age: 46-100 years), who were diagnosed and treated by appropriate therapeutic procedures between January 2000 and December 2010, were enrolled in this study. Patients were stratified into two groups on the basis of age: Elderly (≥ 75 years old) and non-elderly (< 75 years old). Baseline clinical characteristics as well as cumulative survival rates were then compared between the two groups. Univariate and multivariate analyses were used to identify the factors associated with prolonged overall survival of patients in each group. Cumulative survival rates in the two groups were calculated separately for each modified Japan Integrated Stage score (mJIS score) category by the Kaplan-Meier method. In addition, we compared the cumulative survival rates of elderly and non-elderly patients with good hepatic reserve capacity (≤ 2 points as per mJIS). RESULTS: In the elderly group, the proportion of female patients, patients with absence of hepatitis B or hepatitis C viral infection, and patients with coexisting extrahepatic comorbid illness was higher (56.8% vs 31.1%, P < 0.001; 27.0% vs 16.0%, P = 0.038; 33.8% vs 22.2%, P = 0.047; respectively) than that in the non-elderly group. In the non-elderly group, the proportion of hepatitis B virus (HBV)-infected patients was higher than that in the elderly group (9.4% vs 0%, P = 0.006). The cumulative survival rates in the elderly group were 53.7% at 3 years and 32.9% at 5 years, which were equivalent to those in the non-elderly group (55.9% and 39.4%, respectively), as shown by a log-rank test (P = 0.601). In multivariate analysis, prolonged survival was significantly associated with the extent of liver damage and stage (P < 0.001 and P < 0.001, respectively), but was not associated with patient age. However, on individual evaluation of factors in both groups, stage was significantly (P < 0.001) associated with prolonged survival. Regarding mJIS scores of ≤ 2, the rate of female patients with this score was higher in the elderly group when compared to that in the non-elderly group (P = 0.012) and patients ≥ 80 years of age tended to demonstrate shortened survival. CONCLUSION: Survival of elderly HCC patients was associated with liver damage and stage, but not age, except for patients ≥ 80 years with mJIS score ≤ 2.

DOI： 10.3748/wjg.v18.i16.1926

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Roles of Collagen and Periostin Expression by Cranial Neural Crest Cells during Soft Palate Development Reviewed International journal

Kyoko Oka, Masaki J. Honda, Eichi Tsuruga, Yuji Hatakeyama, Keitaro Isokawa, Yoshihiko Sawa

Journal of Histochemistry and Cytochemistry 60 ( 1 ) 57 - 68 2012.1

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DOI： 10.1369/0022155411427059

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Immunohistochemical examination of novel rat monoclonal antibodies against mouse and human podoplanin Reviewed

Chiaki Kaji, Yuta Tsujimoto, Mika Kato Kaneko, Yukinari Kato, Yoshihiko Sawa

Acta Histochemica et Cytochemica 45 ( 4 ) 227 - 237 2012

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DOI： 10.1267/ahc.12008

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Fibrillin-1 and Fibrillin-2 Are Essential for Formation of Thick Oxytalan Fibers in Human Nonpigmented Ciliary Epithelial Cells In Vitro Reviewed International journal

Kaori Yamanouchi, Eichi Tsuruga, Kyoko Oka, Yoshihiko Sawa, Hiroyuki Ishikawa

CONNECTIVE TISSUE RESEARCH 53 ( 1 ) 14 - 20 2012

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DOI： 10.3109/03008207.2011.602767

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Immunohistochemical and immunocytochemical localization of amylase in rat parotid glands and von Ebner's glands by ion etching-immunoscanning electron microscopy Reviewed

Junko Yahiro, Tetsuichiro Inai, Akihito Tsutsui, Atsuko Sato, Toshikazu Nagato, Kunihisa Taniguchi, Eichi Tsuruga, Yoshihiko Sawa

Acta Histochemica et Cytochemica 44 ( 5 ) 201 - 212 2011.8

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DOI： 10.1267/ahc.10039

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Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation Reviewed International journal

Mika Kato Kaneko, Wei Tian, Shingo Takano, Hiroyuki Suzuki, Yoshihiko Sawa, Yasukazu Hozumi, Kaoru Goto, Kentaro Yamazaki, Chifumi Kitanaka, Yukinari Kato

Biochemical and Biophysical Research Communications 406 ( 4 ) 608 - 613 2011.3

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DOI： 10.1016/j.bbrc.2011.02.102

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Stretch stimuli increase fibulin-5/EMILIN-1 complex on oxytalan fibers in human periodontal ligament cells Reviewed

Kazuki Nakashima, Eichi Tsuruga, Yuka Nakatomi, Yoshinori Yamauchi, Yuichiro Hata, Sachio Tamaoki, Yoshihiko Sawa, Hiroyuki Ishikawa

Orthodontic Waves 70 ( 1 ) 15 - 20 2011.3

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DOI： 10.1016/j.odw.2010.09.001

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EMILIN-1 regulates the amount of oxytalan fiber formation in periodontal ligaments in vitro Reviewed International journal

Yuka Nakatomi, Eichi Tsuruga, Kazuki Nakashima, Yoshihiko Sawa, Hiroyuki Ishikawa

Connective Tissue Research 52 ( 1 ) 30 - 35 2011.2

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DOI： 10.3109/03008207.2010.502982

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Expression of podoplanin and classical cadherins in salivary gland epithelial cells of klotho-deficient mice Reviewed

Ikuko Amano, Yuri Imaizumi, Chiaki Kaji, Hiroshi Kojima, Yoshihiko Sawa

Acta Histochemica et Cytochemica 44 ( 6 ) 267 - 276 2011

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DOI： 10.1267/ahc.11037

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The effect of valproic Acid on mesenchymal pluripotent cell proliferation and differentiation in extracellular matrices. International journal

Yuji Hatakeyama, Junko Hatakeyama, Atsushi Takahashi, Kyoko Oka, Eichi Tsuruga, Tetsuichiro Inai, Yoshihiko Sawa

Drug target insights 5 1 - 9 2011

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Valproic acid (2-n-propylpentanoic acid, VPA) is a widely used antiepileptic and anticonvulsant drug. Previous studies have reported that VPA effects osteogenesis in vivo and in vitro, yet it remains unclear whether VPA promotes cell differentiation of osteoblasts derived from mesenchymal cells. The purpose of this study was to clarify the effect of VPA on undifferentiated pluripotent mesenchymal cell proliferation and differentiation into osteoblasts while analyzing the impact of the absence or presence of extracellular matrices (ECMs). Mouse mesenchymal cells were cultured on non-coated plastic, type I collagen-coated, and fibronectin-coated plates in the absence or presence of VPA. A cell proliferation assay was performed in which modified formazan dye content was analyzed and proliferation nuclear antigen (PCNA)-positive cells were counted at various concentrations of VPA. A high concentration of VPA did not clearly alter cell morphology, but large numbers of stress fibers were observed in these cells and the cell proliferation ratio was decreased with positive PCNA counts. In the presence of matrices, the cell proliferation ratio decreased at low VPA concentrations compared with the ratio obtained in the absence of these ECMs. On the other hand, VPA promoted osteoblastic differentiation in the presence of type I collagen. These findings indicate that for undifferentiated mesenchymal cells, VPA promotes a decrease in the cell proliferation rate in the presence of ECMs and promotes osteoblastic differentiation, both of which could provide insight into additional mechanisms of osteoblastic cell differentiation caused by VPA.

DOI： 10.4137/DTI.S6534

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歯根膜オキシタラン線維形成過程におけるEMILIN-1の機能

中冨佑香, 中島一記, 久永豊, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 69回 184 - 184 2010.9

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Immunoelectron microscopic study of podoplanin localization in mouse salivary gland myoepithelium Reviewed

Minoru Hata, Ikuko Amano, Eichi Tsuruga, Hiroshi Kojima, Yoshihiko Sawa

Acta Histochemica et Cytochemica 43 ( 2 ) 77 - 82 2010

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DOI： 10.1267/ahc.10011

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Immunohistochemical examination for the distribution of podoplanin-expressing cells in developing mouse molar tooth germs Reviewed

Yuri Imaizumi, Ikuko Amano, Eichi Tsuruga, Hiroshi Kojima, Yoshihiko Sawa

Acta Histochemica et Cytochemica 43 ( 5 ) 115 - 121 2010

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DOI： 10.1267/ahc.10023

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Fibulin-4 and -5, but not Fibulin-2, are Associated with Tropoelastin Deposition in Elastin-Producing Cell Culture Reviewed

Yoshinori Yamauchi, Eichi Tsuruga, Kazuki Nakashima, Yoshihiko Sawa, Hiroyuki Ishikawa

Acta Histochemica et Cytochemica 43 ( 6 ) 131 - 138 2010

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DOI： 10.1267/ahc.10026

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Immunohistochemical examination on the distribution of cells expressed lymphatic endothelial marker podoplanin and LYVE-1 in the mouse tongue tissue Reviewed

Yuya Noda, Ikuko Amano, Minoru Hata, Hiroshi Kojima, Yoshihiko Sawa

Acta Histochemica et Cytochemica 43 ( 2 ) 61 - 68 2010

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DOI： 10.1267/ahc.10008

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Fibulin-5 contributes to microfibril assembly in human periodontal ligament cells Reviewed

Yutaka Hisanaga, Kazuki Nakashima, Eichi Tsuruga, Yuka Nakatomi, Yuji Hatakeyama, Hiroyuki Ishikawa, Yoshihiko Sawa

Acta Histochemica et Cytochemica 42 ( 5 ) 151 - 157 2009.10

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DOI： 10.1267/ahc.09021

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Stretching stimulates fibulin-5 expression and controls microfibril bundles in human periodontal ligament cells Reviewed

K. Nakashima, E. Tsuruga, Y. Hisanaga, H. Ishikawa, Y. Sawa

Journal of Periodontal Research 44 ( 5 ) 622 - 627 2009.10

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DOI： 10.1111/j.1600-0765.2008.01170.x

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Integrin αvβ3 regulates microfibril assembly in human periodontal ligament cells Reviewed

E. Tsuruga, A. Sato, T. Ueki, K. Nakashima, Y. Nakatomi, H. Ishikawa, T. Yajima, Y. Sawa

Tissue and Cell 41 ( 2 ) 85 - 89 2009

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

DOI： 10.1016/j.tice.2008.07.005

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Expression of podoplanin in the mouse tooth germ and apical bud cells Reviewed

Yoshihiko Sawa, Kana Iwasawa, Hiroyuki Ishikawa

Acta Histochemica et Cytochemica 41 ( 5 ) 121 - 126 2008.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1267/ahc.08019

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Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α Reviewed

Kana Iwasawa, Takeshi Kameyama, Hiroyuki Ishikawa, Yoshihiko Sawa

Acta Histochemica et Cytochemica 41 ( 5 ) 115 - 120 2008.10

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DOI： 10.1267/ahc.08017

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Expression of podoplanin in the mouse salivary glands Reviewed International journal

Minoru Hata, Takeshi Ueki, Atsuko Sato, Hiroshi Kojima, Yoshihiko Sawa

Archives of Oral Biology 53 ( 9 ) 835 - 841 2008.9

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DOI： 10.1016/j.archoralbio.2008.02.006

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Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium Reviewed International journal

Yoshihiko Sawa, Eichi Tsuruga, Kana Iwasawa, Hiroyuki Ishikawa, Shigemitsu Yoshida

Cell and Tissue Research 333 ( 2 ) 237 - 252 2008.8

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DOI： 10.1007/s00441-008-0625-5

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The expression of E-selectin and chemokines in the cultured human lymphatic endothelium with lipopolysaccharides Reviewed International journal

Yoshihiko Sawa, Eichi Tsuruga

Journal of Anatomy 212 ( 5 ) 654 - 663 2008.5

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DOI： 10.1111/j.1469-7580.2008.00892.x

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Expression of junctional adhesion molecules on the human lymphatic endothelium Reviewed International journal

Takeshi Ueki, Kana Iwasawa, Hiroyuki Ishikawa, Yoshihiko Sawa

MICROVASCULAR RESEARCH 75 ( 2 ) 269 - 278 2008.3

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DOI： 10.1016/j.mvr.2007.07.005

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LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium Reviewed International journal

Yoshihiko Sawa, Takeshi Ueki, Minoru Hata, Kana Iwasawa, Eichi Tsuruga, Hiroshi Kojima, Hiroyuki Ishikawa, Shigemitsu Yoshida

Journal of Histochemistry and Cytochemistry 56 ( 2 ) 97 - 109 2008.2

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DOI： 10.1369/jhc.7A7299.2007

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Effects of bFGF on suppression of collagen type I accumulation and scar tissue formation during wound healing after mucoperiosteal denudation of rat palate Reviewed International journal

Wookjin Choi, Hitoshi Kawanabe, Yoshihiko Sawa, Kunihisa Taniguchi, Hiroyuki Ishikawa

ACTA ODONTOLOGICA SCANDINAVICA 66 ( 1 ) 31 - 37 2008

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DOI： 10.1080/00016350701884612

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Effects of TNF-alpha on leukocyte adhesion molecule expressions in cultured human lymphatic endothelium Reviewed International journal

Yoshihiko Sawa, Yukitaka Sugimoto, Takeshi Ueki, Hiroyuki Ishikawa, Atuko Sato, Toshikazu Nagato, Shigemitsu Yoshida

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55 ( 7 ) 721 - 733 2007.7

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DOI： 10.1369/jhc.6A7171.2007

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[A case of recrudescent groove pancreatitis, which was in remission by proximal gastrectomy with vagotomy for gastric cancer].

Hideki Aragane, Hideki Fujii, Takaharu You, Atuhiro Morita, Morimichi Miyazaki, Kiyoshi Morita, Tohru Ohkawara, Shinji Fukumitu, Yoshihiko Sawa, Yasuo Ohkawara

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 103 ( 5 ) 537 - 42 2006.5

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This report describes our experience with a 60 year old male who suffered from a recrudescence of groove pancreatitis. He had been treated by conservative medication therapy by proton pump inhibitor used for therapy of duodenal ulcer, and was in remission. During a follow-up one year later, endoscopy revealed gastric cancer, for which a proximal gastrectomy and vagotomy were performed. The patient continues to remain in remission for the groove pancreatitis. Our experience with the clinical course of this disease, in which treatment for duodenal ulcer was used effectively, offers new insights into the progression and therapy of groove pancreatitis.

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Intracellular distribution of desmoplakin in human odontoblasts Reviewed International journal

Y Sawa, S Kuroshima, Y Yamaoka, S Yoshida

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 53 ( 9 ) 1099 - 1108 2005.9

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DOI： 10.1369/jhc.4A6525.2005

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Expression of cys-cys chemokine ligand 21 on human gingival lymphatic vessels Reviewed International journal

S Kuroshima, Y Sawa, Y Yamaoka, K Notani, S Yoshida, N Inoue

TISSUE & CELL 36 ( 2 ) 121 - 127 2004.4

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DOI： 10.1016/j.tice.2003.10.004

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Reduction of alkaline phosphatase activity in aged human osteogenic periodontal ligament fibroblasts exhibiting short telomeres Reviewed International journal

Y Sawa, Y Yamaoka, S Kuroshima, S Yoshida

CELL AND TISSUE RESEARCH 315 ( 3 ) 331 - 337 2004.3

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DOI： 10.1007/s00441-003-0837-7

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Expression of Toll-like receptors 2 and 4 on human intestinal lymphatic vessels Reviewed International journal

S Kuroshima, Y Sawa, T Kawamoto, Y Yamaoka, K Notani, S Yoshida, N Inoue

Microvascular Research 67 ( 1 ) 90 - 95 2004.1

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DOI： 10.1016/j.mvr.2003.09.005

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Plastic casts and confocal laser scanning microscopy applied to the observation of enamel tubules in the red Kangaroo (Macropus rufus).

Masatsugu Suzuki, Natsumi Ushijima, Ayako Kohno, Yoshihiko Sawa, Shigemitsu Yoshida, Mitsuo Sekikawa, Noriyuki Ohtaishi

Anatomical science international 78 ( 1 ) 53 - 61 2003.3

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Scanning electron microscopy for plastic casts and confocal laser scanning microscopy for Villanueva bone-stained ground sections were used together to observe enamel tubules in red kangaroo molars. Although the tubular structures such as terminals, bends, expansions, splits, divergences and rejoinings in this species were within the variations of marsupial species, their morphological characteristics were demonstrated with extremely clear and persuasive images. Thus, the combined observations of plastic casts by scanning electron microscopy and Villanueva bone-stain sections by confocal laser scanning microscopy were found to be of value for the investigation of enamel tubules and tubular structures in other hard tissues.

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Production of colony-stimulating factor in human dental pulp fibroblasts Reviewed

Y Sawa, Y Horie, Y Yamaoka, N Ebata, T Kim, S Yoshida

JOURNAL OF DENTAL RESEARCH 82 ( 2 ) 96 - 100 2003.2

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Cultured periodontal ligament fibroblasts express diverse connexins Reviewed International journal

Y Yamaoka, Y Sawa, N Ebata, N Ibuki, S Yoshida

TISSUE & CELL 34 ( 6 ) 375 - 380 2002.12

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DOI： 10.1016/S0040-8166(02)00038-1

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Different expressions of connexin 43 and 32 in the fibroblasts of human dental pulp Reviewed

N Ibuki, Y Yamaoka, Y Sawa, T Kawasaki, S Yoshida

TISSUE & CELL 34 ( 3 ) 170 - 176 2002.6

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DOI： 10.1016/S0040-8166(02)00028-9

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Immunoelectron microscopic study of PECAM-1 expression on lymphatic endothelium of the human tongue Reviewed

N Ebata, Y Sawa, Y Nodasaka, Y Yamaoka, S Yoshida, Y Totsuka

TISSUE & CELL 33 ( 3 ) 211 - 218 2001.6

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Desmoplakin as a specific marker of lymphatic vessels Reviewed

N Ebata, Y Nodasaka, Y Sawa, Y Yamaoka, S Makino, Y Totsuka, S Yoshida

MICROVASCULAR RESEARCH 61 ( 1 ) 40 - 48 2001.1

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DOI： 10.1006/mvre.2000.2280

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Double expressions of connexin 43 and 32 in human periodontal ligament fibroblasts Reviewed

Y Yamaoka, Y Sawa, N Ebata, N Ibuki, S Yoshida, T Kawasaki

TISSUE & CELL 32 ( 4 ) 328 - 335 2000.8

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Desmosomal proteins in cultured and intact human periodontal ligament fibroblasts Reviewed

Y Yamaoka, Y Sawa, N Ebata, S Yoshida, T Kawasaki

TISSUE & CELL 31 ( 6 ) 605 - 609 1999.12

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Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans Reviewed

L Dong, KI Shibata, Y Sawa, A Hasebe, Y Yamaoka, S Yoshida, T Watanabe

INFECTION AND IMMUNITY 67 ( 6 ) 3061 - 3065 1999.6

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Lymphatic endothelium of the human tongue expresses multiple leukocyte adhesion molecules Reviewed

N Ebata, Y Sawa, Y Ashikaga, Y Yamaoka, M Suzuki, Totsuka, V, S Yoshida

TISSUE & CELL 31 ( 1 ) 34 - 38 1999.2

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歯周疾患に起因する糖尿病性腎症と糖尿病増悪連鎖

梶原弘一郎, 沢禎彦（ Role： Joint author）

北隆館 2024.10

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ネッター頭頸部・口腔顎顔面の臨床解剖学アトラス

Norton, Neil Scott, 前田, 健康（Chapter 14 舌）

エルゼビア・ジャパン,医歯薬出版 (発売) 2018.9 （ ISBN:9784263458266 ）

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Total pages：xiv, 706p Language：Japanese

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臨床免疫・アレルギー科特別増刊号『サイトカインのすべて』

矢田純一, 宮坂信之（ Role： Joint author , 4.ケモカイン 6) CXCL-6）

科学評論社 2012.5

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口腔解剖学 = Oral anatomy

井出, 吉信, 前田, 健康, 天野, 修, 脇田, 稔, 山下, 靖雄（血管学総論）

医歯薬出版 2009.11 （ ISBN:9784263456347 ）

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Total pages：212p Language：Japanese

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糖尿病マウス腎におけるSGLT2and VCAM-1発現について

梶原弘一郎, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2023 2023

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P.gingivalis LPS誘導性糖尿病性腎症モデルマウスにおけるSGLT2の過剰発現についての研究

梶原弘一郎, 沢禎彦, 玉置幸雄

日本解剖学会総会・全国学術集会抄録集(CD-ROM) 128th 2023

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Diabetic nephropathy and the exacerbation of diabetes caused by the periodontal disease

梶原弘一郎, 沢禎彦

月刊細胞 55 ( 4 ) 2023

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P.gingivalis LPS誘導性糖尿病性腎症マウスにおけるSGLT2の過剰発現について

梶原弘一郎, 沢禎彦, 玉置幸雄

日本解剖学会総会・全国学術集会講演プログラム・抄録集 127th 2022

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ビスフォスフォネートによる骨吸収抑制は敗血症マウスの萎縮胸腺を再生させる

山下潤朗, 藤本啓貴, 沢稔彦, 平野雅裕, 沢禎彦, 宮園祥爾

日本再生医療学会総会(Web) 20th 2021

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Study on overexpression of SGLT2 in the kidney of a P. gingivalis LPS-induced diabetic nephropathy mouse model

梶原弘一郎, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2021 2021

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Porphyromonas gingivalis LPSが誘発する糖尿病性腎症における腎臓の生理活性分子の発現に関する免疫組織化学的研究

Kajiwara Koichiro, 藤田隆寛, 沢禎彦

Journal of Oral Biosciences Supplement 2020 216 - 216 2020.9

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Language：Japanese Publisher：(一社)歯科基礎医学会

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敗血症マウスにゾレドロン酸を投与すると免疫系が賦活され治癒が加速する

山下潤朗, 藤本啓貴, 平野雅裕, 沢禎彦, 沢稔彦

日本骨形態計測学会雑誌 30 ( 1 ) S98 - S98 2020

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Immunohistochemical study for the expression of renal physiologically active molecules in Porphyromonas gingivalis LPS-induced diabetic nephropathy

KAJIWARA Koichiro, 藤田隆寛, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2020 2020

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CLEC-2を介した頭蓋冠骨芽細胞の石灰化抑制

高良憲洋, 梶原弘一郎, 藤田隆寛, 坂上竜資, 沢禎彦, 小島寛

日本解剖学会総会・全国学術集会講演プログラム・抄録集 125th 237 - 237 2020

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Porphyromonas. gingivalis LPSが誘導する糖尿病性腎症の発症とTLR4阻害剤による効果

梶原弘一郎, 高良憲洋, 藤田隆寛, 坂上竜資, 小島寛, 沢禎彦

Journal of Oral Biosciences Supplement 2019 343 - 343 2019.10

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ポドプラニン欠損マウスにおけるフェノタイプの検討

高良憲洋, 梶原弘一郎, 藤田隆寛, 坂上竜資, 小島寛, 沢禎彦

日本解剖学会総会・全国学術集会講演プログラム・抄録集 124th 2019

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Podoplaninを基軸とする骨研究の新展開

沢禎彦

岡山歯学会雑誌 38 ( 1 ) 1 - 10 2019

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CLEC-2による頭蓋冠骨芽細胞の石灰化抑制

高良憲洋, 梶原弘一郎, 藤田隆寛, 坂上竜資, 沢禎彦, 小島寛

Journal of Oral Biosciences Supplement (Web) 2019 2019

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Porphyromonas.gingivalis LPSが誘導する糖尿病性腎症の発症とTLR4阻害剤による効果

梶原弘一郎, 高良憲洋, 藤田隆寛, 坂上竜資, 小島寛, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2019 2019

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P.gingivalis LPSに起因する糖尿病性腎症の発症とTLR阻害剤による予防効果に関する研究

梶原弘一郎, 高良憲洋, 高田俊輔, 玉置幸雄, 吉永泰周, 沢禎彦, 坂上竜資

日本歯周病学会会誌 60 ( 秋季特別 ) 129 - 129 2018.10

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ポドプラニンを基軸とする基礎研究の展開

沢禎彦

岡山歯学会雑誌 37 ( 2 ) 78 - 79 2018

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P.gingivalis LPSに起因する糖尿病性腎症の発症とTLR阻害剤による予防効果に関する研究

梶原弘一郎, 高良憲洋, 高田俊輔, 玉置幸雄, 吉永泰周, 沢禎彦, 坂上竜資

日本歯周病学会会誌(Web) 60 2018

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小児がんの化学療法に起因する多数歯欠損に対し矯正治療とインプラント補綴治療を行った長期経過症例

北城紗和, 沢禎彦, 稲田浩子, 玉置幸雄, 石川博之

日本矯正歯科学会大会プログラム・抄録集 77th 340 - 340 2018

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培養骨芽細胞の石灰化におけるpodoplaninの役割

竹縄智紘, KIM T., 北村哲也, 佐藤嘉晃, 沢禎彦, 飯田順一郎

日本矯正歯科学会大会プログラム・抄録集 77th 243 - 243 2018

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Porphyromonas gingivalis lipopolysaccharideが誘導する糖尿病性腎症とTLR4阻害の効果

梶原弘一郎, 高田俊輔, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 43 ( 1 ) 22 - 22 2017.12

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ヒト歯根膜線維芽細胞のオキシタラン線維形成における成長因子の影響

鴨頭奈央子, 松田裕子, 畠山雄次, 沢禎彦, 石川博之

日本再生歯科医学会学術大会および総会プログラム・抄録集 14th ( 1 ) 23 - 23 2017

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化学合成ロイシンリッチアメロジェニンペプチドの骨芽細胞および軟骨細胞動態に与える影響

松田裕子, 鴨頭奈央子, 畠山雄次, 沢禎彦, 玉置幸雄, 石川博之

日本矯正歯科学会大会プログラム・抄録集 76th 192 - 192 2017

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LAMP1は化学合成されたロイシンリッチアメロジェニンペプチドの骨芽細胞分化に関与する

松田裕子, 畠山雄次, 中島一記, 鴨頭奈央子, 畠山純子, 玉置幸雄, 沢禎彦, 石川博之

再生医療 16 2017

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LAMP-1は化学合成ロイシンリッチアメロジェニンペプチドの骨芽細胞分化に関与する

松田裕子, 畠山雄次, 中島一記, 鴨頭奈央子, 畠山純子, 玉置幸雄, 沢禎彦, 石川博之

日本再生歯科医学会学術大会および総会プログラム・抄録集 14th ( 1 ) 22 - 22 2017

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Wnt1-Cre;PdpnΔ/Δマウス歯・骨の形態学的検討

高良憲洋, 加地千晶, 畠山雄次, 小島寛, 沢禎彦

日本解剖学会総会・全国学術集会講演プログラム・抄録集 122nd 2017

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著明な転位を認めた有痛性分裂膝蓋骨骨折の1例

今村惠一郎, 萎沢利行, 村瀬鎮雄, 曽雌茂, 間浩通, 奥津裕也, 清水禎彦

埼玉県医学会雑誌 51 ( 1 ) 241 - 246 2016.11

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Wheat Germ Agglutinin(WGA)によるヒト歯根膜線維芽細胞由来オキシタラン線維の検出の検討

鴨頭奈央子, 藤田隆寛, 中島一記, 松田裕子, 畠山純子, 畠山雄次, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement 2016 446 - 446 2016.9

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Wheat Germ Agglutinin(WGA)によるヒト歯根膜線維芽細胞由来オキシタラン線維の検出の検討

鴨頭奈央子, 藤田隆寛, 中島一記, 松田裕子, 畠山純子, 畠山雄次, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement (Web) 2016 2016

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レクチンを用いた歯根膜におけるオキシタラン線維の検出の検討

鴨頭奈央子, 藤田隆寛, 中島一記, 松田裕子, 畠山雄次, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 42 ( 1 ) 22 - 22 2016

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化学合成により作製されたLRAPの骨芽細胞分化に与える影響

松田裕子, 畠山雄次, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 42 ( 1 ) 21 - 21 2016

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歯周組織形成過程におけるLysosome-associated membrane proteins(LAMPs)の免疫組織学的局在の検討

畠山雄次, 畠山純子, 岡暁子, 稲井哲一朗, 沢禎彦

日本歯科医師会雑誌 69 ( 5 ) 506 - 506 2016

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Porphyromonas gingivalis lipopolysaccharideによる糖尿病性腎症の発症に関する研究

梶原弘一郎, 高田俊輔, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 42 ( 増補 ) 38 - 38 2016

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持続的機械ストレス環境下でのpodoplanin発現

竹縄智紘, KIM T., 高草木祐理, 北村哲也, 佐藤嘉晃, 沢禎彦, 飯田順一郎

日本矯正歯科学会大会プログラム・抄録集 75th 197 - 197 2016

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正常マウス骨組織におけるポドプラニンの発現

沢禎彦

日本歯科医師会雑誌 69 ( 5 ) 506 - 506 2016

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A8 GFPマウスをドナーとするapical bud分化モデルの開発(一般口演3,第42回福岡歯科大学学会総会抄録)

丸尾直樹, 坂上竜資, 吉永泰周, 岡村和彦, 沢禎彦

福岡歯科大学学会雑誌 41 28 - 28 2015.12

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小児がん治療経験者における永久歯形成障害の左右差について(Laterality of tooth formation anomalies in long-term survivors treated by anti-cancer chemotherapies of pediatric cancers)

西村紗和, 沢禎彦, 稲田浩子, 上田耕一郎, 梶井貴史, 石川博之, 水田祥代

日本小児血液・がん学会雑誌 52 ( 4 ) 255 - 255 2015.10

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ペプチド固相合成法(F-moc法)により作製されたLRAPの軟骨および骨形成に与える影響

松田裕子, 畠山雄次, 中島一記, 鴨頭奈央子, 畠山純子, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement 2015 410 - 410 2015.9

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ペプチド固相合成法(F-moc法)により作製されたLRAPの軟骨および骨形成に与える影響

松田裕子, 畠山雄次, 中島一記, 鴨頭奈央子, 畠山純子, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement (Web) 2015 2015

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GFPマウスをドナーとするapical bud分化モデルの開発

丸尾直樹, 坂上竜資, 吉永泰周, 岡村和彦, 沢禎彦

福岡歯科大学学会雑誌 41 ( 1 ) 16 - 17 2015

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エナメルマトリックスデリバディブによる軟骨細胞分化および増殖に与えるLAMP-3の関与に関する検討

松田裕子, 畠山雄次, 沢禎彦, 石川博之

日本再生歯科医学会学術大会および総会プログラム・抄録集 13th ( 1 ) 55 - 55 2015

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オキシタラン線維形成における歯原性上皮細胞の関与

吉良迪子, 板家智, 尾崎正雄, 岡暁子, 沢禎彦

Journal of Oral Biosciences Supplement 2014 132 - 132 2014.9

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軟骨細胞動態におけるGrowth/Differentiation Factorsの機能的差異に関する検討(The study of functional differentiation of GDFs in chondrocyte cell kinetics)

畠山雄次, 松田裕子, 畠山純子, 岡暁子, 阿南壽, 稲井哲一朗, 石川博之, 沢禎彦

Journal of Oral Biosciences Supplement 2014 193 - 193 2014.9

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オキシタラン線維形成における歯原性上皮細胞の関与

吉良迪子, 板家智, 尾崎正雄, 岡暁子, 沢禎彦

Journal of Oral Biosciences Supplement 2014 144 - 144 2014.9

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歯周病原菌由来TLRリガンドによる糖尿病性腎症の促進

高田俊輔, 梶原弘一郎, 石川博之, 沢禎彦

Journal of Oral Biosciences Supplement 2014 159 - 159 2014.9

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歯の発生において、Fibrillin-1とFibrilin-2は上皮間葉で異なる発現を示す

吉良迪子, 岡暁子, 板家智, 敦賀英知, 沢禎彦, 尾崎正雄

福岡歯科大学学会雑誌 40 ( 1 ) 46 - 46 2014.7

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歯周病原菌由来TLRリガンドによる糖尿病性腎症の促進

高田俊輔, 梶原弘一郎, 石川博之, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2014 2014

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糖尿病環境下の腎糸球体におけるtoll-like receptor(TLR)2と4の発現

高田俊輔, 内山貴誠, 敦賀英知, 畠山雄次, 石川博之, 沢禎彦

糖尿病 57 ( 5 ) 389 - 389 2014

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オキシタラン線維形成における歯原性上皮細胞の関与

吉良迪子, 吉良迪子, 板家智, 尾崎正雄, 岡暁子, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2014 2014

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歯周病原菌由来LPSによるTLRを介した糖尿病性腎症の促進について

高田俊輔, 梶原弘一郎, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 40 ( 1 ) 17 - 17 2014

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マウス下顎切歯歯胚の幹細胞におけるSox2およびOct4の発現

丸尾直樹, 岡村和彦, 沢禎彦, 坂上竜資

Journal of Oral Biosciences Supplement (Web) 2014 2014

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歯根膜線維形成に対する歯原性上皮細胞の関与

板家智, 吉良迪子, 田村翔悟, 比嘉ありさ, 敦賀英知, 沢禎彦, 岡暁子, 尾崎正雄

小児歯科学雑誌 52 ( 2 ) 224 - 224 2014

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無線LANを活用したeラーニングによる組織学実習に対する学生の評価

畠山雄次, 北河憲雄, 稲井哲一朗, 沢禎彦

日本歯科医学教育学会総会・学術大会プログラム・抄録集 33rd 108 - 108 2014

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小児がんに対する化学療法と永久歯欠損率について

西村紗和, 沢禎彦, 稲田浩子, 梶井貴史, 石川博之, 水田祥代

日本小児血液・がん学会雑誌 51 ( 4 ) 340 - 340 2014

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タイプI型とII型糖尿病マウスにおける腎リンパ管増生について

内山貴誠, 高田俊輔, 石川博之, 沢禎彦

糖尿病 57 ( 5 ) 390 - 390 2014

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歯根膜オキシタラン線維の形成過程におけるMAGP-1解析

藤田隆寛, 山之内香, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 10 ( 1 ) 43 - 43 2014

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ヒト無色素毛様体上皮細胞およびヒト歯根膜線維芽細胞におけるオキシタラン線維の分解過程

川越慈, 敦賀英知, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 40 ( 1 ) 19 - 19 2014

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エナメル芽細胞におけるLeucine-rich Amelogenin Peptideの局在

畠山純子, 畠山雄次, 松本典祥, 泉利雄, 沢禎彦, 笹野泰之, 阿南壽

日本歯科保存学会学術大会プログラムおよび講演抄録集(Web) 140th 99 - 99 2014

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口蓋発生時のFibrillin1蛋白の発現は細胞増殖を調節している

比嘉ありさ, 岡暁子, 吉良迪子, 敦賀英知, 沢禎彦, 尾崎正雄

日本口蓋裂学会雑誌 39 ( 2 ) 196 - 196 2014

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Porphyromonas gingivalis由来LPSは腎糸球体のTLR2/4を介して糖尿病性腎症を促進する

高田俊輔, 梶原弘一郎, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 73rd 184 - 184 2014

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歯の発生において、Fibrillin-1とFibrillin-2は上皮-間葉で異なる発現を示す

吉良迪子, 岡暁子, 板家智, 敦賀英知, 沢禎彦, 尾崎正雄

福岡歯科大学学会雑誌 39 ( 増補 ) 30 - 30 2013.12

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糖尿病環境下の糸球体内皮細胞におけるTLR2とTLR4の発現

高田俊輔, 内山貴誠, 敦賀英知, 畠山雄次, 石川博之, 沢禎彦

Journal of Oral Biosciences Supplement 2013 128 - 128 2013.9

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タイプ1型と2型糖尿病マウスにおける腎リンパ管新生

内山貴誠, 高田俊輔, 敦賀英知, 畠山雄次, 石川博之, 沢禎彦

Journal of Oral Biosciences Supplement 2013 209 - 209 2013.9

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内臓脂肪ゲノムバンクの構築と新規内臓脂肪関連遺伝子の同定

中山一大, 柳沢佳子, 岩本禎彦, 宮下洋, 田原康玄, 恩田智彦, 片嶋充弘, 岡田浩一, 福島省吾, 香川靖雄

DNA多型 21 245 - 249 2013.5

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The expression of Fibrillin-1 and -2 during palatal development

HIGA Arisa, OKA Kyoko, KIRA Michiko, TSURUGA Eichi, SAWA Yoshihiko, OZAKI Masao

51 ( 2 ) 155 - 155 2013.4

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糖尿病モデルマウス腎糸球体におけるTLR2とTLR4の発現

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糖尿病合併症 27 ( Supplement 1 ) 139 - 139 2013

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I型とII型糖尿病モデルマウスにおける腎リンパ管新生について

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福岡歯科大学学会雑誌 39 ( 1 ) 43 - 44 2013

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日本矯正歯科学会大会プログラム・抄録集 72nd 206 - 206 2013

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ヒト歯根膜オキシタラン線維の分解機構

川越慈, 敦賀英知, 沢禎彦, 石川博之

日本歯周病学会学術大会プログラムおよび講演抄録集 56th ( 春季特別 ) 102 - 102 2013

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日本矯正歯科学会大会プログラム・抄録集 72nd 201 - 201 2013

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歯根膜オキシタラン線維形成におけるMAGP-1の解析

山之内香, 敦賀英知, 沢禎彦, 石川博之

日本歯周病学会学術大会プログラムおよび講演抄録集 56th ( 春季特別 ) 102 - 102 2013

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日本矯正歯科学会大会プログラム・抄録集 72nd 152 - 152 2013

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Journal of Oral Biosciences Supplement (Web) 2013 2013

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タイプ1型と2型糖尿病マウスにおける腎リンパ管新生

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糖尿病モデルマウスの腎リンパ管増生について

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日本解剖学会総会・全国学術集会講演プログラム・抄録集 118th 2013

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糖尿病モデルマウス腎糸球体におけるTLR2とTLR4の発現

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福岡歯科大学学会雑誌 39 ( 1 ) 52 - 52 2013

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歯の発生において,Fibrillin-1とFibrillin-2は上皮一間葉で異なる発現を示す

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福岡歯科大学学会雑誌 39 2013

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糖尿病環境下の腎糸球体におけるTLR2とTLR4の発現について

高田俊輔, 内山貴誠, 敦賀英知, 畠山雄次, 石川博之, 沢禎彦

日本解剖学会総会・全国学術集会講演プログラム・抄録集 118th 2013

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正常マウスグリア細胞が発現するポドプラニンとカドヘリン

加地千晶, 友岡みわ, 畠山雄次, 敦賀英知, 小島寛, 沢禎彦

日本解剖学会総会・全国学術集会講演プログラム・抄録集 118th 2013

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ヒト歯根膜線維芽細胞によるオキシタラン線維の分解過程

川越慈, 山之内香, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 9 ( 1 ) 60 - 60 2013

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歯の発生におけるLecin rich Amelogenin peptideの発現解析

畠山純子, 畠山雄次, 松本典祥, 春名千英子, 諸富孝彦, 泉利雄, 沢禎彦, 阿南壽

福岡歯科大学学会雑誌 39 ( 1 ) 52 - 52 2013

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小児がん治療後の歯科的長期フォローアップ

西村紗和, 沢禎彦, 稲田浩子, 上田耕一郎, 石川博之, 水田祥代

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細胞伸展装置を用いた擬似的歯根膜におけるオキシタラン線維の走行解析

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九州矯正歯科学会雑誌 9 ( 1 ) 60 - 60 2013

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Leucine-rich Amelogenin Peptide Promotes Chondrogenesis

畠山純子, 畠山雄次, 松本典祥, 春名千英子, 諸冨孝彦, 泉利雄, 沢禎彦, 笹野泰之, 阿南壽

日本歯科保存学雑誌 56 ( 6 ) 2013

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オキシタラン線維は線維芽細胞長軸に直交し走行する

中島一記, 山内由宣, 藤田隆寛, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement 2012 120 - 120 2012.9

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歯周組織におけるFibulin-4とLOXL2/エラスチン複合体の解析

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement 2012 157 - 157 2012.9

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歯根膜形成におけるLysosome-associated membrane protein-1(LAMP-1)の免疫組織化学的局在について

畠山雄次, 畠山純子, 岡曉子, 敦賀英知, 稲井哲一朗, 沢禎彦

Journal of Oral Biosciences Supplement 2012 158 - 158 2012.9

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成長板軟骨におけるアメロジェニンおよびLAMP-1の免疫組織学的研究

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日本結合組織学会学術大会抄録集 44th 74 - 74 2012

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毛様体小帯の形成においてFibrillin-1とFibrillin-2は必須である

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日本結合組織学会学術大会抄録集 44th 23 - 23 2012

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歯の発生におけるFibrillin1およびFibrillin2の発現

吉良迪子, 岡暁子, 敦賀英知, 沢禎彦, 尾崎正雄

小児歯科学雑誌 50 ( 2 ) 169 - 169 2012

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サイトカインの種類 4.ケモカイン 6)CXCL6

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月刊臨床免疫・アレルギー科 57 ( Suppl.21 ) 292 - 295 2012

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マウス歯周組織形成過程におけるLysosome-associated membrane protein-1(LAMP-1)の免疫組織学的検討

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解剖学雑誌 87 ( 2 ) 47 - 47 2012

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EMILIN-1はfibrillin-1と細胞内で結合してオキシタラン線維の形成量を調節している

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日本結合組織学会学術大会抄録集 44th 66 - 66 2012

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Fibulin-4はLOXL2/エラスチン複合体形成を調節する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

日本結合組織学会学術大会抄録集 44th 67 - 67 2012

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軟口蓋発生におけるPeriostinの役割

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日本口蓋裂学会雑誌 37 ( 2 ) 128 - 128 2012

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Fibulin-4は弾性線維形成過程においてLOXL-2/エラスチン複合体形成を調整する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 71st 167 - 167 2012

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歯周組織におけるFibulin-4とLOXL2/エラスチン複合体の解析

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement (Web) 2012 2012

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歯周組織においてFibulin-4はLOXL2/エラスチン複合体形成を調節する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 38 ( 1 ) 78 - 78 2012

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比嘉ありさ, 比嘉ありさ, 岡暁子, 吉良迪子, 吉良迪子, 敦賀英知, 沢禎彦, 尾崎正雄

福岡歯科大学学会雑誌 38 ( 1 ) 79 - 79 2012

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九州矯正歯科学会雑誌 8 ( 1 ) 88 - 88 2012

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ラット口蓋部瘢痕組織における弾性系線維に対するbFGF投与の効果

植木猛士, 秦雄一郎, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 8 ( 1 ) 88 - 88 2012

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細胞伸展刺激によりオキシタラン線維は歯根膜線維芽細胞長軸に直交し走行する

中島一記, 山内由宣, 藤田隆寛, 玉置幸雄, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 71st 287 - 287 2012

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オキシタラン線維は線維芽細胞長軸に直交し走行する

中島一記, 山内由宣, 藤田隆寛, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences Supplement (Web) 2012 2012

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歯根膜形成におけるLysosome-associated membrane protein-1(LAMP-1)の免疫組織化学的局在について

畠山雄次, 畠山純子, 岡曉子, 敦賀英知, 稲井哲一朗, 沢禎彦

Journal of Oral Biosciences Supplement (Web) 2012 2012

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小児癌の抗癌剤治療が引き起こす永久歯の形成障害について

西村紗和, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 38 ( 1 ) 68 - 68 2012

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The Elastic System Fiber Formation in the Wound Healing Process for Rat Palates and the Influences of bFGF Administration

植木猛士, 秦雄一郎, 盛冨雅則, 阿部朗子, 玉置幸雄, 敦賀英知, 沢禎彦, 谷口邦久, 石川博之

福岡歯科大学学会雑誌 38 ( 1 ) 19 - 25 2012

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小児がんに対する自家末梢血幹細胞移植を付帯する超大量化学療法後に発生する歯の形成障害について

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九州矯正歯科学会雑誌 7 ( 1 ) 66 - 66 2011.12

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歯根膜のオキシタラン線維形成過程においてEMILIN-1はFibrillin-1沈着量の調節を行う

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 7 ( 1 ) 64 - 64 2011.12

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歯周組織の弾性線維形成過程においてFibulin-4とFibulin-5はエラスチン沈着に関与する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 7 ( 1 ) 64 - 64 2011.12

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DNA多型の臨床応用高脂血症感受性遺伝子TRIB1は高血圧とも関連する

石塚裕美, 中山一大, 小川歩美, 柳沢佳子, 後藤孝也, 岩本禎彦, 宮下洋

DNA多型 19 271 - 274 2011.5

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マウス顎下腺の顆粒管における胎盤カドヘリンの産生

天野郁子, 今泉友里, 野田雄也, 加地千晶, 友岡みわ, 畠山雄次, 敦賀英知, 小島寛, 沢禎彦

Journal of Oral Biosciences 53 ( Supplement ) 195 - 195 2011

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オキシタラン線維の形成過程におけるLTBP-2の機能について

敦賀英知, 岡暁子, 中島一記, 畠山雄次, 石川博之, 沢禎彦

解剖学雑誌 86 ( 1 ) 21 - 21 2011

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Fibulinは歯周組織の弾性線維形成過程においてエラスチン/LOX複合体を形成する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 70th 231 - 231 2011

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ラット口蓋の創傷治癒過程においてbFGF投与は瘢痕組織による歯列成長抑制を緩和する

秦雄一郎, 植木猛士, 敦賀英知, 沢禎彦, 谷口邦久, 石川博之

日本矯正歯科学会大会プログラム・抄録集 70th 305 - 305 2011

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軟口蓋発生時に特徴的にあらわれる細胞外基質とその役割

岡暁子, 敦賀英知, 畠山雄次, 吉良迪子, 尾崎正雄, 沢禎彦

小児歯科学雑誌 49 ( 4 ) 423 - 423 2011

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正常マウスの脳におけるポドプラニンとカドヘリンの共発現

加地千晶, 友岡みわ, 天野郁子, 今泉友里, 野田雄也, 畠山雄次, 敦賀英知, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 38th ( 1 ) 51 - 52 2011

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術直後のbFGF投与がラット口蓋の創傷治癒過程におけるコラーゲン線維の蓄積と歯列幅径に与える効果

秦雄一郎, 植木猛士, 玉置幸雄, 敦賀英知, 沢禎彦, 谷口邦久, 石川博之

日本口蓋裂学会雑誌 36 ( 2 ) 112 - 112 2011

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ヒト無色素毛様体上皮細胞によるオキシタラン線維形成

山之内香, 川越慈, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 38th ( 1 ) 47 - 47 2011

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顔面発生におけるFibrillin 1およびFibrillin 2の発現

吉良迪子, 岡暁子, 敦賀英知, 沢禎彦, 尾崎正雄

福岡歯科大学学会総会プログラム・予稿集 38th 2011

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EMILIN-1のオキシタラン線維形成における量の調節機構

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences 53 ( Supplement ) 184 - 184 2011

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EMILIN-1は歯根膜オキシタラン線維の形成量を調節する

中冨佑香, 敦賀英知, 山内由宣, 中島一記, 沢禎彦, 石川博之

日本結合組織学会学術大会抄録集 43rd 133 - 133 2011

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Fibulin-4はエラスチン/LOXL-2複合体形成に関係し,弾性線維の形成を調整する

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 38th ( 1 ) 47 - 47 2011

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歯根膜オキシタラン線維形成過程におけるEMILIN-1の役割

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 70th 230 - 230 2011

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Growth/Differentiation Factor-5(GDF-5)による歯髄由来細胞の象牙芽細胞分化に与える影響

畠山雄次, 畠山純子, 岡暁子, 敦賀英知, 稲井哲一朗, 沢禎彦

解剖学雑誌 86 ( 1 ) 21 - 21 2011

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口腔組織と脳におけるポドプラニンとカドヘリンの共発現

加地千晶, 友岡みわ, 天野郁子, 今泉友里, 野田雄也, 畠山雄次, 敦賀英知, 小島寛, 沢禎彦

Journal of Oral Biosciences 53 ( Supplement ) 136 - 136 2011

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歯周組織の弾性線維形成過程におけるFibulinとエラスチン/LOX複合体の解析

山内由宣, 中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences 53 ( Supplement ) 184 - 184 2011

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小児がんに対するブスルファンの超大量投与療法が引き起こす永久歯の形成障害について

西村紗和, 沢禎彦, 稲田浩子, 石川博之

日本矯正歯科学会大会プログラム・抄録集 70th 203 - 203 2011

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アメロジェニン遺伝子機能喪失マウスの歯根形成完了期におけるセメント質吸収に関する組織学的検討

畠山雄次, 畠山純子, 岡暁子, 敦賀英知, 稲井哲一朗, 沢禎彦

Journal of Oral Biosciences 53 ( Supplement ) 184 - 184 2011

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小児がん治療のためのブスルファン投与が引き起こす永久歯の形成障害について

西村紗和, 沢禎彦, 稲田浩子, 石川博之

Journal of Oral Biosciences 53 ( Supplement ) 137 - 137 2011

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超大量化学療法が誘起する歯の形成障害に及ぼす通常化学療法の相乗効果の検討

西村紗和, 沢禎彦, 稲田浩子, 石川博之

日本小児血液・がん学会学術集会・日本小児がん看護学会・がんの子供を守る会公開シンポジウムプログラム・総会号 53rd-9th-16th ( プログラム・総会号 ) 381 - 381 2011

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New trends in the study of podoplanin as a cell morphological regulator

Yoshihiko Sawa

Japanese Dental Science Review 46 ( 2 ) 165 - 172 2010.8

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DOI： 10.1016/j.jdsr.2010.01.003

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歯根膜組織に存在する歯原性上皮幹細胞

岡暁子, 諸隈正和, 諸隈正和, 沢禎彦, 磯川桂太郎, 本田雅規

再生医療 9 2010

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歯根膜のオキシタラン線維形成過程におけるEMILIN-1の機能

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

解剖学雑誌 85 ( 2 ) 87 - 87 2010

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マウス軟口蓋・口蓋腱膜形成におけるTGF-βシグナルの役割

岡暁子, 本田雅規, 敦賀英知, 畠山雄次, 磯川桂太郎, 沢禎彦

解剖学雑誌 85 ( Supplement ) 179 - 179 2010

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細胞伸展刺激によりfibulin-5は発現しオキシタラン線維の凝集を調節する

中島一記, 中冨佑香, 久永豊, 久永豊, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 69th 184 - 184 2010

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Fibulin-4とFibulin-5は微細線維へのエラスチン沈着に関係する

山内由宜, 内冨佑香, 中嶋一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 37th ( 1 ) 29 - 29 2010

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LTBP-2・fibulin-5複合体によるオキシタラン線維形成の制御

敦賀英知, 中島一記, 岡暁子, 石川博之, 沢禎彦

日本結合組織学会学術大会抄録集 42nd 2010

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ラット口蓋部の創傷治癒における筋線維芽細胞のアポトーシスに対するbFGF投与の定量的評価

植木猛士, 秦雄一郎, 敦賀英知, 沢禎彦, 谷口邦久, 石川博之

日本矯正歯科学会大会プログラム・抄録集 69th 257 - 257 2010

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歯根膜オキシタラン線維形成過程におけるEMILIN-1の機能

中冨佑香, 中島一記, 久永豊, 敦賀英知, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 69th ( 1 ) 108 - 108 2010

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オキシタラン線維の形成過程におけるfibulin-5の発現と機能

中島一記, 中冨佑香, 山内由宣, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 37th ( 1 ) 34 - 34 2010

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アメロジェニン遺伝子欠損マウスにおけるセメント質吸収亢進過程に関する検討

畠山雄次, 畠山純子, 稲井哲一朗, 沢禎彦

日本結合組織学会学術大会抄録集 42nd 2010

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骨芽細胞におけるGrowth/Differentiation Factor-5(GDF-5)のMatrix Metalloproteinases(MMPs)酵素活性制御に関する検討

畠山雄次, 畠山純子, 沢禎彦

解剖学雑誌 85 ( 2 ) 87 - 87 2010

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EMILIN-1はオキシタラン線維の形成量を調節する

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 37th ( 1 ) 28 - 28 2010

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小児血液腫瘍の化学療法が引き起こす歯の形成障害について

西村紗和, 稲田浩子, 沢禎彦, 石川博之

日本矯正歯科学会大会プログラム・抄録集 69th 302 - 302 2010

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造血幹細胞移植療法が引き起す歯の形成障害について

西村紗和, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 37th ( 1 ) 35 - 35 2010

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TGF-βシグナルは,軟口蓋間葉細胞の細胞増殖と基質産生を促進する

岡暁子, 本田雅規, 敦賀英知, 畠山雄次, 磯川桂太郎, 沢禎彦

Journal of Oral Biosciences 52 ( Supplement ) 94 - 94 2010

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EMILIN-1は伸展刺激により増加するオキシタラン線維の形成量を調節する

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences 52 ( Supplement ) 123 - 123 2010

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イオンエッチング走査電顕による糖尿病ラット唾液腺の観察

八尋純子, 敦賀英知, 沢禎彦

解剖学雑誌 85 ( 2 ) 87 - 87 2010

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小児血液腫瘍の治療がもたらした歯の形成障害について

西村紗和, 稲田浩子, 沢禎彦, 石川博之

日本小児血液学会・日本小児がん学会・日本小児がん看護学会・財団法人がんの子供を守る会公開シンポジウムプログラム・総会号 52nd-26th-8th-15th ( プログラム・総会号 ) 394 - 394 2010

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リンパ管内皮細胞のケモカイン発現

岩澤佳奈, 中島一記, 畠山雄次, 敦賀英知, 沢禎彦

解剖学雑誌 85 ( 2 ) 87 - 87 2010

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伸展は歯周組織におけるフィブリン-5発現を刺激し、ミクロ繊維束を制御する(Stretching stimulates fibulin-5 expression, and controls microfibril bundles in periodontium)

中島一記, 敦賀英知, 石川博之, 沢禎彦

解剖学雑誌 84 ( 2 ) 70 - 70 2009.6

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歯周組織においてインテグリンαvβ3はオキシタラン線維形成を制御する(Integrin αvβ3 regulates oxytalan fibers formation in periodontium)

敦賀英知, 中島一記, 石川博之, 沢禎彦

解剖学雑誌 84 ( 2 ) 70 - 70 2009.6

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Stretching modulates oxytalan fibers in human periodontal ligament cells

E. Tsuruga, K. Nakashima, H. Ishikawa, T. Yajima, Y. Sawa

JOURNAL OF PERIODONTAL RESEARCH 44 ( 2 ) 170 - 174 2009.4

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DOI： 10.1111/j.1600-0765.2008.01099.x

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P-1 マウスリンパ管における白血球接着因子の発現(ポスター1,第35回福岡歯科大学学会総会抄録)

岩澤佳奈, 植木猛士, 天野郁子, 野田雄也, 沢禎彦, 石川博之

福岡歯科大学学会雑誌 35 ( 1 ) 47 - 47 2009.3

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EGFR遺伝子変異と関連する患者因子について

田中知明, 松岡優, 須谷顕尚, 長井良昭, 小山信之, 宮沢仁志, 金澤實, 清水禎彦, 池淵研二, 森田智視, 小林国彦, 萩原弘一

日本薬学会年会要旨集 129年会 ( 4 ) 274 - 274 2009.3

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マウス唾液腺のリンパ管分布に関する免疫組織化学的検索

野田雄也, 久保田智彦, 天野郁子, 畑実, 今泉友里, 敦賀英知, 畠山雄次, 小島寛, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 147 - 147 2009

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ポドプラニンの唾液腺筋上皮特異性に関する研究

畑実, 天野郁子, 敦賀英知, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 33 - 33 2009

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口蓋発生における神経堤由来細胞の動態

岡暁子, 畠山雄次, 敦賀英知, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 33 - 34 2009

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リンパ管内皮細胞における白血球接着因子の発現に関する研究

岩澤佳奈, 敦賀英知, 石川博之, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 113 - 113 2009

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マウス歯胚におけるポドプラニンの発現について

今泉友里, 畑実, 天野郁子, 野田雄也, 畠山雄次, 敦賀英知, 小島寛, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 74 - 74 2009

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骨芽細胞におけるGrowth/Differentiation Factor-5のMatrix Metalloproteinases酵素活性制御に関する検討

畠山雄次, 丸谷由里子, 畠山純子, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 124 - 124 2009

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マウス歯胚におけるポドプラニンの発現について

今泉友里, 天野郁子, 野田雄也, 畠山雄次, 岡暁子, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 33 - 33 2009

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歯根膜のオキシタラン線維形成過程におけるEMILIN-1の機能解析

中冨佑香, 中島一記, 久永豊, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 5 ( 1 ) 73 - 73 2009

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細胞伸展装置を用いた歯根膜オキシタラン線維の解析-Fibulin-5の発現と機能解析-

中島一記, 中冨佑香, 久永豊, 敦賀英知, 沢禎彦, 石川博之

九州矯正歯科学会雑誌 5 ( 1 ) 56 - 56 2009

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口腔組織内リンパ管分布の検索に有用な内皮細胞抗原の検討

野田雄也, 畑実, 天野郁子, 今泉友里, 敦賀英知, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 47 - 47 2009

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歯根膜オキシタラン線維形成過程におけるEMILIN-1の機能

中冨佑香, 中島一記, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences 51 ( Supplement ) 143 - 143 2009

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TNF-αはマウス舌リンパ管にICAM-1とVCAM-1の発現を誘導する

岩澤佳奈, 植木猛士, 西村紗和, 中島一記, 中冨佑香, 敦賀英知, 畠山雄次, 石川博之, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 164 - 164 2009

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LYVE-1陽性マクロファージの口腔粘膜における分布

西村紗和, 植木猛士, 中冨佑香, 中島一記, 岩澤佳奈, 畠山雄次, 敦賀英知, 石川博之, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 161 - 161 2009

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Klotho遺伝子発現欠如マウスの老化唾液腺における筋上皮の分布について

天野郁子, 畑実, 野田雄也, 今泉友里, 敦賀英知, 畠山雄次, 小島寛, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 146 - 146 2009

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細胞伸展刺激によるオキシタラン線維の凝集機構

中島一記, 中冨佑香, 敦賀英知, 沢禎彦, 石川博之

Journal of Oral Biosciences 51 ( Supplement ) 93 - 93 2009

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マウス口腔上皮と唾液腺筋上皮におけるポドブラニンの発現について

畑実, 岩澤佳奈, 天野郁子, 野田雄也, 今泉友里, 敦賀英知, 小島寛, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 85 - 85 2009

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LTBP-2・fibulin-5複合体によるオキシタラン線維形成の制御

敦賀英知, 中島一記, 中冨佑香, 畠山雄次, 石川博之, 沢禎彦

Journal of Oral Biosciences 51 ( Supplement ) 144 - 144 2009

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fibulin-5はオキシタラン線維の凝集を調節する

中島一記, 中冨佑香, 久永豊, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 34 - 34 2009

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歯根膜のオキシタラン線維形成過程におけるEMILIN-1の機能

中冨佑香, 中島一記, 久永豊, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 35 - 35 2009

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klotho遺伝子抑制マウスの唾液腺における筋上皮特異抗原の発現に関する研究

天野郁子, 畑実, 野田雄也, 今泉友里, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 36th ( 1 ) 47 - 47 2009

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術直後のbFGFの局所投与はラット口蓋部の創傷治癒における筋線維芽細胞のアポトーシスを促進する

秦雄一郎, 植木猛士, 敦賀英知, 沢禎彦, 谷口邦久, 石川博之

日本矯正歯科学会大会プログラム・抄録集 68th 250 - 250 2009

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大腸菌由来リポポリサッカライドによるTHP-1細胞のマトリックスメタロプロテアーゼ9の発現誘導(Matrix metalloproteinase 9 induction by Escherichia coli lipopolysaccharide in THP-1 cells)

沢禎彦, 敦賀英知

福岡歯科大学学会雑誌 34 ( 4 ) 113 - 123 2008.12

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リンパ管内皮細胞のリポタイコ酸およびリポポリサッカライドによるCXCL11およびCX3CL1の産生誘導(Induction of CXCL11 and CX3CL1 chemokine expressions in the human lymphatic endothelium with lipoteichoic acid and lipopolysaccharide)

沢禎彦, 敦賀英知

福岡歯科大学学会雑誌 34 ( 4 ) 125 - 132 2008.12

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Immunocytochemical localization of parotin subunit in submandibular glands of the Japanese Monkey, Macaca fuscata

Junko Yahiro, Kunihisa Taniguchi, Eichi Tsuruga, Yoshihiko Sawa

Journal of Nara Medical Association 59 ( 5 ) 149 - 155 2008.10

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ヒト歯周靱帯細胞におけるインテグリンαvβ3によるミクロフィブリル線維形成(microfibril assembly)の制御(Integrin alphavbeta3 regulates microfibril assembly in human periodontal ligament cells)

敦賀英知, 中島一記, 中冨佑香, 石川博之, 沢禎彦

Journal of Oral Biosciences 50 ( Suppl. ) 166 - 166 2008.9

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牽引はフィブリン-5発現を刺激し、オキシタラン線維形成を制御する(Stretching stimulates fibulin-5 expression, and controls oxytalan fibers assembly)

中島一記, 中冨佑香, 敦賀英知, 石川博之, 沢禎彦

Journal of Oral Biosciences 50 ( Suppl. ) 166 - 166 2008.9

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歯周靱帯におけるオキシタラン線維の牽引による変調(Stretching modulates oxytalan fibers in periodontal ligaments)

中冨佑香, 中島一記, 敦賀英知, 石川博之, 沢禎彦

Journal of Oral Biosciences 50 ( Suppl. ) 166 - 166 2008.9

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GDF-5の軟骨形成細胞凝集への影響

畠山雄次, 沢禎彦

Journal of Oral Biosciences 50 ( Supplement ) 200 - 200 2008

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イオンエッチング免疫走査電顕法による免疫組織細胞化学的研究

八尋純子, 谷口邦久, 沢禎彦

Journal of Oral Biosciences 50 ( Supplement ) 130 - 130 2008

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マウス口腔上皮におけるポドプラニンの発現

畑実, 岩澤佳奈, 植木猛士, 小島寛, 沢禎彦

福岡歯科大学学会雑誌 34 ( 1 ) 28 - 28 2008

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マウスリンパ管における白血球接着因子の発現

岩澤佳奈, 植木猛士, 天野郁子, 野田雄也, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 35th ( 1 ) 34 - 35 2008

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オキシタラン線維の沈着過程におけるEMILINの役割

中冨佑香, 敦賀英知, 中島一記, 久永豊, 石川博之, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 35th ( 1 ) 35 - 35 2008

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リンパ管内皮細胞における白血球接着因子の発現

植木猛士, 岩澤佳奈, 畑実, 敦賀英知, 沢禎彦, 石川博之

福岡歯科大学学会総会プログラム・予稿集 35th ( 1 ) 34 - 34 2008

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マウス口腔上皮におけるポドプラニンの発現

畑実, 植木猛士, 岩澤佳奈, 小島寛, 沢禎彦

解剖学雑誌 83 ( 1 ) 33 - 33 2008

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リンパ管内皮細胞におけるjunctional adhesion moleculeの発現

植木猛士, 岩澤佳奈, 石川博之, 沢禎彦

福岡歯科大学学会雑誌 34 ( 1 ) 28 - 28 2008

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ヒトリンパ管内皮細胞におけるjunctional adhesion moleculeの発現

植木猛士, 岩澤佳奈, 石川博之, 沢禎彦

解剖学雑誌 83 ( 1 ) 32 - 32 2008

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細胞伸展刺激により発現が促進されるfibulin-5は,オキシタラン線維の凝集を調節する

中島一記, 敦賀英知, 中冨佑香, 久永豊, 石川博之, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 35th ( 1 ) 36 - 36 2008

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内皮細胞における白血球接着因子の発現(Leukocyte Adhesion Molecule Expressions on Vascular Endothelium)

沢禎彦

福岡歯科大学学会雑誌 33 ( 4 ) 159 - 170 2007.12

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口蓋部創傷治癒過程におけるbFGF投与後のcollagen remodelingの病理組織学的観察

崔旭鎮, 川鍋仁, 秦雄一郎, 石川博之, 谷口邦久, 沢禎彦

九州矯正歯科学会雑誌 3 ( 1 ) 102 - 102 2007.12

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長野県内における透析患者様の通院状況について

武舎玲子, 富澤良策, 古家悟, 西澤幸子, 稲玉益子, 井沢好雄, 太田喜義, 内山篤, 高井博子, 唐木芳昭, 松本史郎, 大西禎彦

長野県透析研究会誌 30 ( 1 ) 132 - 133 2007.9

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接合部接着分子を発現する口腔リンパ管(Oral lymphatic vessels express junctional adhesion molecules)

植木猛士, 岩澤佳奈, 畑実, 敦賀英知, 石川博之, 沢禎彦

Journal of Oral Biosciences 49 ( Suppl. ) 185 - 185 2007.8

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ヒト口腔粘膜上皮におけるpodoplaninの発現(Expression of podoplanin in the human oral mucous epithelium)

岩澤佳奈, 植木猛士, 畑実, 敦賀英知, 石川博之, 沢禎彦

Journal of Oral Biosciences 49 ( Suppl. ) 186 - 186 2007.8

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マウス唾液腺におけるpodoplaninの発現(Expression of podoplanin in the mouse salivary glands)

畑実, 植木猛士, 佐藤敦子, 小島寛, 沢禎彦

Journal of Oral Biosciences 49 ( Suppl. ) 192 - 192 2007.8

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ビタミン関連酵素の多型とテイラーメイド栄養

香川靖雄, 日笠志津, 影山光代, 百合本真弓, 金胎芳子, 小島早貴, 石井由香, 柳沢佳子, 平岡真実, 岩本禎彦

ビタミン 81 ( 4 ) 142 - 142 2007.4

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Fibulin-5は微細線維上に存在し,微細線維の形成を調節する

敦賀英知, 矢嶋俊彦, 沢禎彦

Journal of Oral Biosciences 49 ( Supplement ) 181 - 181 2007

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口蓋部創傷治癒過程におけるbFGF投与は瘢痕組織の形成を抑制する

CHOI Wook-Jin, 谷口邦久, 川鍋仁, 沢禎彦, 秦雄一郎, 石川博之

日本口蓋裂学会雑誌 32 ( 2 ) 244 - 244 2007

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マウス口腔上皮におけるポドプラニンの発現

畑実, 岩澤桂奈, 植木猛士, 小島寛, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 34th 2007

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リンパ管内皮細胞におけるjunctional adhesion moleculeの発現

植木猛士, 岩澤桂奈, 畑実, 石川博之, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 34th 2007

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ラット口蓋部骨露出創の治癒過程においてbFGF投与がcollagen remodelingに与える効果

崔旭鎮, 川鍋仁, 秦雄一郎, 石川博之, 谷口邦久, 沢禎彦

福岡歯科大学学会総会プログラム・予稿集 33rd ( 1 ) 51 - 52 2006

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MMP-2によるヒト歯根膜線維芽細胞増殖の抑制(Matrix metalloproteinase 2 suppresses the proliferation of human periodontal ligament fibroblasts)

山口穣治, 沢禎彦, 黒嶋伸一郎, 山岡雄司, 吉田重光, 飯田順一郎

北海道歯学雑誌 26 ( 2 ) 115 - 124 2005.12

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TNFαによるヒトリンパ内皮細胞におけるVCAM-1及びICAM-1の誘導(The induction of VCAM-1 and ICAM-1 in human lymphatic endothelial cells by TNFα)

沢禎彦, 山岡雄司, 吉田重光

Journal of Oral Biosciences 47 ( Suppl. ) 185 - 185 2005.9

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MMP2(matrix metalloproteinase2)によるPDLF(periodontal ligament fibroblast)増殖の抑制(The suppression of PDLF proliferation by MMP2)

山口穣治, 沢禎彦, 黒嶋伸一郎, 山岡雄司, 吉田重光, 飯田順一郎

Journal of Oral Biosciences 47 ( Suppl. ) 159 - 159 2005.9

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THP-1細胞におけるプロテアーゼE感受性LPS複合体のMMP9産生誘導

沢禎彦, 黒嶋伸一郎, 山岡雄司, 吉田重光

解剖学雑誌 80 ( 1 ) 13 - 13 2005

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TLR4/MD-2を介したLPS認識によるCCR6の発現抑制

黒嶋伸一郎, 沢禎彦, 山岡雄司, 吉田重光, 井上農夫男

Journal of Oral Biosciences 47 ( Supplement ) 144 - 144 2005

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Connexin43のC末端はG0-G1期におけるp27の分解を抑制する

山岡雄司, 沢禎彦, 黒嶋伸一郎, 吉田重光

Journal of Oral Biosciences 47 ( Supplement ) 189 - 189 2005

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Expression of cys-cys chemokine ligand 21 on lymphatic vessels of human dental pulp

黒嶋伸一郎, 黒嶋伸一郎, 沢禎彦, 山岡雄司, 井上農夫男, 吉田重光

北海道歯学雑誌 26 ( 2 ) 272 - 280 2005

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THP-1におけるCCR7の発現誘導はToll-like receptor4を介する

黒嶋伸一郎, 沢禎彦, 山岡雄司, 吉田重光, 井上農夫男

解剖学雑誌 80 ( 1 ) 13 - 13 2005

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THP-1におけるToll-like receptor4を介したCCR7の発現誘導

黒嶋伸一郎, 沢禎彦, 山岡雄司, 吉田重光, 井上農夫男

Journal of Oral Biosciences 46 ( 5 ) 453 - 453 2004

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ヒト歯髄象牙芽細胞におけるデスモプラキンの細胞内分布

沢禎彦, 黒嶋伸一郎, 山岡雄司, 吉田重光

Journal of Oral Biosciences 46 ( 5 ) 453 - 453 2004

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ヒト歯根膜線維芽細胞におけるN-cadherin及びcadherin-11の発現(Expression of N-cadherin and cadherin-11 in human periodontal ligament fibroblasts)

太田祥一, 山岡雄司, 沢禎彦, 黒嶋伸一郎, 吉田重光, 川崎貴生

北海道歯学雑誌 24 ( 2 ) 238 - 245 2003.12

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Production of bone-associated proteins in human periodontal ligament fibroblasts with telomeric attrition.

Y. Sawa, Y. Yamaoka, S. -L Kuroshima, S. Yoshida

JOURNAL OF DENTAL RESEARCH 82 B85 - B85 2003.6

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老化ヒト歯根膜線維芽細胞の骨関連蛋白の産生

沢禎彦, 黒嶋伸一郎, 山岡雄司, 吉田重光

歯科基礎医学会雑誌 45 ( 5 ) 331 - 331 2003

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ヒト歯肉リンパ管内皮細胞におけるcys-cys chemokine ligand21の発現

黒嶋伸一郎, 沢禎彦, 山岡雄司, 吉田重光, 井上農夫男

歯科基礎医学会雑誌 45 ( 5 ) 371 - 371 2003

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Periodontal ligament fibroblasts express diverse connexins.

Y Yamaoka, Y Sawa, N Ebata, N Ibuki, S Yoshida

JOURNAL OF DENTAL RESEARCH 81 A135 - A135 2002.3

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The telomere length of human periodontal ligament fibroblasts.

Y Sawa, Y Yamaoka, N Ebata, N Ibuki, S Yoshida

JOURNAL OF DENTAL RESEARCH 81 A135 - A135 2002.3

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ヒト歯根膜細胞が発現するコネキシンについて

山岡雄司, 沢禎彦, 吉田重光

解剖学雑誌 77 ( Suppl. ) APPENDIX23 - APPENDIX23 2002.3

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ヒト歯根膜線維芽細胞のテロメア長

沢禎彦, 山岡雄司, 江畑典幸, 吉田重光

歯科基礎医学会雑誌 44 ( 5 ) 427 - 427 2002

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口腔へん平上皮癌細胞株におけるconnexin 26およびconnexin43の検索

山岡雄司, 沢禎彦, 江畑典幸, 吉田重光

歯科基礎医学会雑誌 44 ( 5 ) 476 - 476 2002

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ヒト歯髄線維芽細胞のCSF産生について

沢禎彦, 山岡雄司, 江畑典幸, 伊吹直子, 吉田重光

歯科基礎医学会雑誌 43 ( 5 ) 568 - 568 2001

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培養ヒト歯根膜線維芽細胞が発現するconnexinの検索

山岡雄司, 沢禎彦, 伊吹直子, 江畑典幸, 吉田重光

歯科基礎医学会雑誌 43 ( 5 ) 571 - 571 2001

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Human periodontal ligament fibroblasts express connexin 43

Y Yamaoka, Y Sawa, H Takagi, N Ebata, S Yoshida, T Kawasaki

JOURNAL OF DENTAL RESEARCH 79 ( 5 ) 1250 - 1250 2000.5

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Immunohistochemical identification of lymphatic vessels by an antibody against desmoplakins

N Ebata, Y Sawa, Y Yamaoka, Y Totsuka

JOURNAL OF DENTAL RESEARCH 79 ( 5 ) 1247 - 1247 2000.5

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The in vitro life-span of human periodontal ligament fibroblasts

Y Sawa, A Phillips, J Hollard, S Yoshida, MW Braithwaite

TISSUE & CELL 32 ( 2 ) 163 - 170 2000.4

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DOI： 10.1054/tice.2000.0100

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Impairment of osteocalcin production in senescent periodontal ligament fibroblasts

Y Sawa, A Phillips, J Hollard, S Yoshida, MW Braithwaite

TISSUE & CELL 32 ( 2 ) 198 - 204 2000.4

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DOI： 10.1054/tice.2000.0104

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Immuno-electron microscopic study of the expression of desmosome-associated proteins in cultured human periodontal ligament fibroblasts.

野田坂佳伸, 山岡雄司, 江畑典幸, 沢禎彦, 吉田重光

北海道歯学雑誌 21 ( 1 ) 130 - 135 2000

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Expression of desmosomal proteins in cultured human fibroblasts.

Y Yamaoka, Y Sawa, N Ebata, S Yoshida, T Kawasaki

JOURNAL OF DENTAL RESEARCH 79 578 - 578 2000

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The in vitro lifespan of human periodontal ligament cells.

Y Sawa, S Yoshida, J Hollard, A Phillips, MW Braithwaite

JOURNAL OF DENTAL RESEARCH 79 578 - 578 2000

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Immunoelectron microscope study on the expression or PECAM-1 on the lymphatic endothelium.

N Ebata, Y Sawa, Y Yamaoka, S Yoshida, Y Totsuka

JOURNAL OF DENTAL RESEARCH 79 512 - 512 2000

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ヒト歯髄線維芽細胞におけるConnexin 43とConnexin 32の発現

伊吹直子, 山岡雄司, 沢禎彦, 吉田重光, 川崎貴生

歯科基礎医学会雑誌 42 ( 5 ) 457 - 457 2000

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老化ヒト歯根膜細胞のosteocalcin産生

沢禎彦, 山岡雄司, 江畑典幸, 伊吹直子, 吉田重光

歯科基礎医学会雑誌 42 ( 5 ) 493 - 493 2000

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歯根膜線維芽細胞におけるconnexin43およびconnexin32の検索

山岡雄司, 沢禎彦, 伊吹直子, 江畑典幸, 吉田重光

歯科基礎医学会雑誌 42 ( 5 ) 494 - 494 2000

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リンパ管内皮細胞におけるPECAM-1の局在に関する研究

江畑典幸, 沢禎彦, 野田坂佳伸, 山岡雄司, 吉田重光, 戸塚靖則

歯科基礎医学会雑誌 42 ( 5 ) 481 - 481 2000

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Human periodontal ligament fibroblasts express connexin 43.

山岡雄司, 沢禎彦, 伊吹直子, 江畑典幸, 吉田重光, 川崎貴生

北海道歯学雑誌 21 ( 1 ) 43 - 47 2000

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ヒト舌リンパ管内皮細胞における白血球接着因子発現の多様性

江畑典幸, 沢禎彦, 山岡雄司, 吉田重光, 戸塚靖則

歯科基礎医学会雑誌 41 ( 5 ) 492 - 492 1999.8

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歯根膜線維芽細胞におけるデスモゾーム構成蛋白の検索

山岡雄司, 沢禎彦, 江畑典幸, 吉田重光, 川崎貴生

歯科基礎医学会雑誌 41 ( 5 ) 448 - 448 1999.8

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Immunohistochemical study on leukocyte adhesion molecules expressed on lymphatic endothelium

Y Sawa, Y Yamaoka, N Ebata, Y Ashikaga, T Kim, M Suzuki, S Yoshida

MICROVASCULAR RESEARCH 57 ( 3 ) 292 - 297 1999.5

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DOI： 10.1006/mvre.1998.2137

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Expression of immunoglobulin superfamily members on the lymphatic endothelium of inflamed human small intestine

Y Sawa, K Shibata, MW Braithwaite, M Suzuki, S Yoshida

MICROVASCULAR RESEARCH 57 ( 2 ) 100 - 106 1999.3

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DOI： 10.1006/mvre.1998.2132

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Immunohistochemical demonstration of lymphatic vessels in human dental pulp

Y Sawa, S Yoshida, Y Ashikaga, T Kim, Y Yamaoka, M Suzuki

TISSUE & CELL 30 ( 5 ) 510 - 516 1998.10

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DOI： 10.1016/S0040-8166(98)80030-X

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歯髄リンパ管内皮細胞に発現する白血球接着因子の検索

山岡雄司, 沢禎彦, 鈴木正嗣, 吉田重光, 川崎貴生

歯科基礎医学会雑誌 40 ( 抄録 ) 444 - 444 1998.9

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ヒトリンパ管内皮細胞が発現する白血球接着因子

江畑典幸, 沢禎彦, 足利雄一, 鈴木正嗣, 吉田重光, 戸塚靖則

歯科基礎医学会雑誌 40 ( 抄録 ) 385 - 385 1998.9

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Lymphatic endothelium expresses PECAM-1

Y Sawa, S Yoshida, Y Ashikaga, T Kim, Yamaoka, V, H Shiroto

TISSUE & CELL 30 ( 3 ) 377 - 382 1998.6

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DOI： 10.1016/S0040-8166(98)80051-7

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Vascular endothelium of human dental pulp expresses diverse adhesion molecules.

Y Sawa, M Suzuki, S Yoshida

JOURNAL OF DENTAL RESEARCH 77 ( 5 ) 1297 - 1297 1998.5

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Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration

Y Sawa, S Yoshida, KI Shibata, M Suzuki, A Mukaida

TISSUE & CELL 30 ( 2 ) 281 - 291 1998.4

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DOI： 10.1016/S0040-8166(98)80077-3

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Relegation of monophyodont teeth in northern fur seals(Callorhinus ursinus). A histo-embryological and three-dimensional reconstruction study.

向井田純子, 鈴木正嗣, 沢禎彦

北海道歯学雑誌 19 ( 1 ) 19 - 31 1998

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Immuno-histochemical demonstration of the expression of adhesion molecules on the vascular endothelium in human dental pulp.

Y Sawa, M Suzuki, S Yoshida

JOURNAL OF DENTAL RESEARCH 77 673 - 673 1998

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An experimental study on the formation of scar tissue in the rat palate.

KIM T, CHU S, 沢禎彦, 梅田和宏, 石川博之, 中村進治, 吉田重光

北海道歯学雑誌 19 ( 1 ) 52 - 62 1998

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ヒト胸管特異的モノクローナル抗体を用いたヒト歯髄リンパ管の同定

沢禎彦

リンパ学 20 ( 2 ) 61 - 61 1997.11

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歯髄微小循環系内皮細胞が発現する白血球接着因子の検索

沢禎彦

歯科基礎医学会雑誌 39 ( 抄録 ) 435 - 435 1997.9

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Identification of lymphatic vessels by using a monoclonal antibody specific for the human thoracic duct

Y Sawa, A Mukaida, M Suzuki, S Yoshida

MICROVASCULAR RESEARCH 53 ( 2 ) 142 - 149 1997.3

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DOI： 10.1006/mvre.1996.2000

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Microcirculation and defence mechanisms in human dental pulp.

沢禎彦

北海道歯学雑誌 18 ( 2 ) 158 - 159 1997

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Numerical variations of teeth and morphological characteristics of supernumerary teeth in northern fur seals(Callorhinus ursinus).

向井田純子, 鈴木正嗣, 沢禎彦, 牛島夏未, 吉田重光

北海道歯学雑誌 18 ( 1 ) 1997

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ヒト歯髄のリンパ管に関する免疫組織化学的研究

沢禎彦

歯科基礎医学会雑誌 38 ( 抄録 ) 430 - 430 1996.8

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A plastic cast study of enamel tubules in the red kangaroo (Macropus rufus).

鈴木正嗣, 牛島夏未, 沢禎彦, 吉田重光

北海道歯学雑誌 17 ( 1 ) 1996

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THE ENHANCEMENT OF THE HUMAN-IMMUNOGLOBULIN-G FC FRAGMENT-BINDING ACTIVITY OF MYCOPLASMA-SALIVARIUM CELLS BY TRYPSIN TREATMENT IS ASCRIBED TO THE BINDING OF TRYPSIN TO THE FC FRAGMENT

Y SAWA, KI SHIBATA, T WATANABE

FEMS MICROBIOLOGY LETTERS 128 ( 1 ) 9 - 13 1995.4

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A Case report of the sternalis muscle and its innervation.

牛島夏未, 鈴木正嗣, 沢禎彦, 向井田純子, 吉田重光

北海道歯学雑誌 16 ( 2 ) 308 - 311 1995

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Mycoplasma salivarium(MS)のヒトIgG Fc結合活性について

沢禎彦

北海道歯学雑誌 15 ( 2 ) 276 - 290 1994.12

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MEMBRANE-PROTEINS WITH MOLECULAR MASSES OF 88-KDA, 90-KDA AND 150-KDA ARE RESPONSIBLE FOR BINDING OF HUMAN-IMMUNOGLOBULIN-G FC-FRAGMENT TO THE NATIVE CELLS OF MYCOPLASMA-SALIVARIUM

K SHIBATA, Y SAWA, S INOUE, M NODA, T WATANABE

FEMS MICROBIOLOGY LETTERS 123 ( 3 ) 305 - 309 1994.11

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DOI： 10.1016/0378-1097(94)90209-7

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Mycoplasma salivarium細胞のヒトIgG Fc結合活性について

沢禎彦

歯科基礎医学会雑誌 36 ( 抄録 ) 93 - 93 1994.9

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Mycoplasma salivarium細胞のヒトIgG Fc結合活性について

沢禎彦

日本細菌学雑誌 49 ( 2 ) 436 - 436 1994.3

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ACID-PHOSPHATASE PURIFIED FROM MYCOPLASMA-FERMENTANS HAS PROTEIN-TYROSINE PHOSPHATASE-LIKE ACTIVITY

KI SHIBATA, M NODA, Y SAWA, T WATANABE

INFECTION AND IMMUNITY 62 ( 1 ) 313 - 315 1994.1

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PURIFICATION AND CHARACTERIZATION OF MEMBRANE-PROTEIN (90 KDA) FROM MYCOPLASMA SALIVARIUM, WHICH BINDS IMMUNOGLOBULIN (IG)G FC FRAGMENT

Y SAWA, K SHIBATA, M NODA, T WATANABE

MICROBIOLOGY AND IMMUNOLOGY 38 ( 4 ) 257 - 262 1994

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Purification and Characterization of an Acid Phosphates from ┣DBMycoplasma fragments(/)-┫DB(共著)

Microbiology and Immunology 38 ( 2 ) 103 - 107 1994

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Human immunoglobulin G Fc binding activity of Mycoplasma salivarium.

沢禎彦

北海道歯学雑誌 15 ( 2 ) 1994

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ヒトIgGのFc部位と結合するMycoplasma salivariumの細胞膜タンパク質について

沢禎彦

歯科基礎医学会雑誌 35 ( 抄録 ) 185 - 185 1993.9

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Immunoglobulin G Fc Fragment‐Binding Proteins in Mycoplasma salivarium Cells

Yoshihiko Sawa, Tsuguo Watanabe, Ken‐ichiro Shibata

Microbiology and Immunology 36 ( 6 ) 655 - 659 1992

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Presentations

Immunohistochemical study on the abnormal expression of tubular SGLT2 in diabetes model mice with malocclusion-induced hyperglycemia

Kajiwara, K., Sawa, Y.

72th Japanese Association of Dental Research 2024.11.17

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Event date： 2024.11.16 - 2024.11.17

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Abnormal expression of SGLT2 in the kidney of a P. gingivalis LPS-induced diabetic nephropathy mouse model

Kajiwara K, Sawa Y, Fujita T, Tamaoki S

JADR, WEB 2021

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Presentation type：Poster presentation

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An immunohistochemical study on the expression of bioactive molecules in the mouse kidney in P. gingivalis LPS-induced diabetic nephropathy

Kajiwara K, Sawa Y, Fujita T, Tamaoki S

JADR 2020

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Development of scar suppression method applying TGF-β function of microfibril protein

Fujita T, Kajiwara K, Takara K, Sakagami R, Kojima H, Sawa Y, Tamaoki S

2019

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Effect of TLR4 inhibitors on porphyromonas gingivalis LPS-induced diabetic nephropathy

Kajiwara K, Takara K, Fujita T, Kanai T, Sakagami R, Kojima H, Sawa Y, Tamaoki S

2019

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CLEC-2 suppresses calcification in calvarial osteoblasts

Takara K, Kajiwara K, Fujita T, Kanai T, Tamaoki S, Sakagami R, Sawa Y, Kojima H

2019

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Presentation type：Poster presentation

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Study for the diabetic nephropathy;promoted by Porphyromonas gingivalis lipopolysaccharide a;the prevension effect by TLR blocker

Kajiwara K, TakaraK, Takata S, Tamaoki S, Yoshinaga Y, Sawa Y, Sakagami R

2018

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Effects of TLR4 blocking on diabetic nephropathy promoted by the Porphyromonas gingivalis lipopolysaccharide.

Kajiwara K, Takata S, Fujita T, Takara K, Hatakeyama Y, Tamaoki S, Ishikawa H, Sawa Y

2017

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Porphyromonas Gingivalis lipopolysaccharide promote diabetic nephropathy through TLR2.

Kajiwara K, Takata S, Hatakeyama Y, Ishikawa H, Sawa Y

IADR 2016

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The morphological investigation of head and neck organs in the systemic podoplanin knockout mice.

Takara K, Kaji C, Hatakeyama Y, Kojima H, Sawa Y

2016

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The cytokine inductions in glomerular endothelial cells with Porphyromonas gingivalis lipopolysaccharide through TLR2.

Takata S, Kajiwara K, Hatakeyama Y, Ishikawa H, Sawa Y

2016

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Study for the apical bud differentiation model using green mice.

Maruo S, Kajiwara K, Ishikawa H, Sawa Y

IADR 2016

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The expression of podoplanin and bone-associated proteins after mechanical stress.

Takenawa S, Kim T, Takakusaki Y, SatoY, Iida J, Sawa Y

IADR 2016

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Research Projects

骨細胞のPDPN依存性機械受容による破骨細胞誘導と骨改造機構の研究

Grant number：25K13262 2025.04 - 2028.03

日本学術振興会科学研究費助成事業基盤研究(C)

金井壮律, 沢禎彦, 足利雄一

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Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

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骨形成環境による腫瘍排他的ニッチの分子機序の解明：新たながん治療戦略の可能性

Grant number：24K02643 2024.04 - 2028.03

日本学術振興会科学研究費助成事業基盤研究(B)

寺町順平, 冨永辰也, 原田武志, 日浅雅博, 沢禎彦

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Grant amount：\18590000 （ Direct expense: \14300000 、 Indirect expense：\4290000 ）

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Preventive medical research for the nephropathy complication mechanism and diabetes exacerbation through TLR linkage between diabetes and periodontal disease

Grant number：23K09474 2023.04 - 2026.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

梶原弘一郎、沢禎彦

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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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The oral-lung axis mediated by exosomes from oral epithelial cells in COVID-19 and the drug discovery

Grant number：22K19623 2022.06 - 2024.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory) Grant-in-Aid for Challenging Research (Exploratory)

沢禎彦, 加藤幸成, 寺町順平

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Grant amount：\6500000 （ Direct expense: \5000000 、 Indirect expense：\1500000 ）

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Elucidation of the molecular basis of oral-renal association by periodontal disease exosomes in exacerbation of diabetes and complications of nephropathy

Grant number：22H03302 2022.04 - 2025.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

沢禎彦

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Grant amount：\17550000 （ Direct expense: \13500000 、 Indirect expense：\4050000 ）

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Molecular basis of the oral-renal linkage by periodontal disease exosomes in exacerbation of diabetes and complications of nephropathy

Grant number：23K24560 2022.04 - 2025.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

沢禎彦, 加藤幸成, 寺町順平, 坂上竜資

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Grant amount：\17550000 （ Direct expense: \13500000 、 Indirect expense：\4050000 ）

申請者らは、まず、腎糸球体が通常は発現しない自然免疫受容体toll-like receptor TLR2/4を糖尿病環境で異常発現すること、さらに糖尿病モデルマウスを用いて、糖尿病環境で腎に異常発現したTLR2/4は、歯周病原細菌Porphyromonas (P.) gingivalisの有するTLR2リガンドlipopolysaccharide (LPS) に応答して腎症を起こすこと、さらに、尿細管における、通常は発現しない白血球接着因子vascular cell adhesion molecule-1 (VCAM-1)の異常発現と、白血球浸潤による尿細管間質性炎を誘起することを見出した。重度の歯周疾患ではP. gingivalisなど歯周病原細菌はブラッシングで容易に血中に入り菌血症を起こす。血中の歯周病原細菌成分は体循環から腎に入り、構造の複雑な糸玉状の糸球体血管から排除できず糖尿病環境でTLRなど自然免疫系を活性化して腎症の引き金を引くと予想した。一方、sodium-glucose cotransporter 2 (SGLT2)阻害薬の腎症抑制効果が脚光を浴びている。本研究では、糖尿病モデルマウスを用いて、TLR4結合による大腸癌誘発などTLR4活性化による病原性が注目されている歯周病原菌Fusobacterium (F.) nucleatumが、糖尿病の増悪と生存曲線による生存率の有意な低下を引き起こすことを証明した。続いてF. nucleatumがSGLT2の通常は発現しない腎糸球体および遠位尿細管および近位尿細管の内側壁における過剰発現と糖代謝異常の加速を起こすこと、すなわち、糖尿病の増悪の一つの機序が、歯周病原細菌による糸球体・尿細管の炎症性刺激が尿細管におけるSGLT2の異常発現と糖代謝異常に引き続く糖尿病増悪を引き起こす可能性を見出すに至った。

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骨破壊腫瘍進展と骨病変形成における細胞内情報伝達系の恒常的活性化機構の解明と制御

Grant number：21H03111 2021.04 - 2025.03

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B)

寺町順平, 原田武志, 沢禎彦, 安倍正博, 日浅雅博

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Grant amount：\17160000 （ Direct expense: \13200000 、 Indirect expense：\3960000 ）

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骨破壊腫瘍進展と骨病変形成における細胞内情報伝達系の恒常的活性化機構の解明と制御

Grant number：23K21485 2021.04 - 2025.03

日本学術振興会科学研究費助成事業基盤研究(B)

寺町順平, 原田武志, 沢禎彦, 日浅雅博, 安倍正博

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Grant amount：\17160000 （ Direct expense: \13200000 、 Indirect expense：\3960000 ）

本研究では、腫瘍細胞内あるいは腫瘍微小環境側の破骨細胞や骨髄間質細胞での様々な細胞内情報伝達系の恒常的な活性化機構の解明を目的としている。申請者は、セリン、スレオニンフォスファターゼであるPP2Aの内因性阻害因子であるCIP2Aに着目し、CIP2AによるPP2A活性の低下が腫瘍進展や骨病変形成に関わっていることを見出した。今年度は、以下の結果を見出した。① MC3T3-E1を用いた骨芽細胞培養系にCIP2A抑制剤であるTD-52を処理したところ、石灰化結節が誘導され、骨芽細胞分化が促進された。② 骨髄間質細胞と骨髄腫細胞を共培養すると、骨髄間質細胞のCIP2Aの発現が誘導され、VCAM1やVEGFの産生が誘導された。さらに、このように誘導されたCIP2Aは骨髄腫細胞に対する薬剤耐性を惹起した。③ 骨髄腫骨微小環境で高産生されている、TNF-αやIL-6はTAK1の活性化を誘導し、骨髄間質細胞のCIP2A発現を誘導した。
また、今年度の結果の一部を、論文2報に発表した。

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The study of the normal regulatory mechanism in the alveolar bone by PDPN-dependent mechanosensing

Grant number：21K10153 2021.04 - 2024.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

金井壮律, 佐藤嘉晃, 沢禎彦, 足利雄一

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Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）

矯正学的機械的（メカニカル）ストレス環境にある顎骨において、メカニカルストレスを骨リモデリングにトランスダクションする骨細胞の決定的分子は未解決である。代表者らはメカニカルストレスが骨細胞のポドプラニンpodoplanin産生と石灰化を促進し、この石灰化がpodoplanin特異抗体およびpodoplanin受容体である血小板CLEC-2で強力に阻害されることを報告した。また、podoplanin遺伝子Pdpn をコンディショナルにノックアウト (cKO) したマウスWnt1-Cre;PdpnΔ/Δでは矯正学的メカニカルストレスを負荷した顎骨で破骨細胞の集積が見られないことを見出し、podoplaninが骨細胞のメカノトランスダクションを仲介して石灰化に関与すると着想した。本研究は、骨細胞のpodoplaninを介するメカノトランスダクションの分子経路を、Pdpn cKOマウスと培養Pdpn cKO骨細胞、および矯正学的メカニカルストレス実験を応用して可視化することを目的とする。具体的には、矯正学的メカニカルストレスがPdpn cKOマウス顎骨の骨細胞の石灰化物産生と骨リモデリングを促進せず、歯牙移動が急速に起こること、またメカニカルストレスが培養骨芽細胞の石灰化物産生を促進することからメカニカルストレス誘導性のRhoA-ERM-MLCアッセンブリー形成、骨関連タンパク産生の細胞内伝達経路の活性化と石灰化物産生が、培養Pdpn cKO骨細胞では起こらないこと、さらに、CLEC-2陽性マクロファージ系細胞・破骨細胞のpodoplanin陽性骨細胞との接触が骨細胞に突起の収縮、骨芽細胞への幼若化あるいは細胞死による石灰化能の低下をもたらし、Pdpn cKO骨細胞ではそれが起こらないことを示す。

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Study on epidemiological meta-analysis of diabetic nephropathy focusing on complex systems of periodontal disease and intestinal immune disturbance

Grant number：18H03015 2018.04 - 2021.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

SAWA Yoshihiko

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Grant amount：\17550000 （ Direct expense: \13500000 、 Indirect expense：\4050000 ）

It is known that diabetic patients with periodontitis are more likely to develop nephropathy than patients without periodontitis, and that diabetes is more likely to worsen, but the mechanism is unknown. This study showed that renal glomeruli in diabetic patients express TLRs that react with bacterial components and overreact to bacterial components. The intestinal bacteria that enter the blood are sterilized by the liver, but the bacteria that enter the blood from oral tissue due to periodontitis enter the kidneys directly. Glomeruli with complex structures cannot eliminate bacterial components and activate TLRs to release inflammatory factors. As a result, it was suggested that leukocyte adhesion factors and physialogical substances are overproduced in the kidney to promote nephropathy, and that SGLT2, which is responsible for sugar reabsorption, is abnormally expressed and diabetes is exacerbated.

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Elucidation of cancer stem cell niche formation mechanisms of CAF derived from oral tissue using Pdpn-cKO mouse

Grant number：17K19777 2017.06 - 2019.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory) Grant-in-Aid for Challenging Research (Exploratory)

SAWA YOSHIHIKO, HATAKEYAMA YUJI

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Grant amount：\6500000 （ Direct expense: \5000000 、 Indirect expense：\1500000 ）

We aim to discover oncoproteins that promote environmental maintenance for metastasis. In this study, we developed mice where fibroblasts can not make podoplanin (cKO mice) and transplanted cancer cells in mice, it was shown that the formation of fibroblasts around transplanted cancer was weaker in cKO than in the normal, and metastasis was significantly reduced in cKO mice. Therefore, we developed an antibody to cancer-type podoplanin that produced in the human oral carcinoma but not in the normal, and investigated tongue cancer, it was shown that metastasis and recurrence were significantly higher in cancer-type podoplanin-positive patients than in the negative, and that the five-year new metastasis-free survival rate was reduced in cancer-type podoplanin-positive patients. We think that the expression of cancer-type podoplanin is useful as a prognostic factor (July 26, 2018 press release, Okayama University).

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Podoplanin -dependent bone formation mechanism with orthodontic mechanostress.

Grant number：15K11333 2015.04 - 2019.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

Kanai Takenori, Takenawa Tomohiro, Sato Yoshiaki

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Grant amount：\4940000 （ Direct expense: \3800000 、 Indirect expense：\1140000 ）

The expression of podoplanin in cultured osteoblasts subjected to elongation straining was significantly larger than that in cells without straining, and the expression increased with duration of elongation time. The podoplanin mRNA amount in cultured osteoblasts subjected to straining in non-mineralization medium was significantly larger than in unstrained cells in mineralization medium. The cultured osteoblasts increased podoplanin production with longer durations of elongation straining and reached a plateau within 3-5 days. There are significantly less of mineralization products in osteoblasts cultured with antibodies for podoplanin, as well as in cells with both antibodies for osteopontin, and osteocalcin as positive controls. These findings may suggest that mechanostress induces the production of podoplanin, and that podoplanin may contribute to the mineralization in osteoblasts in bone under the circumstances with mechanostress.

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Study on control of scar formation after cleft palate with a wound healing model using rat skin

Grant number：15K11358 2015.04 - 2018.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

Ishikawa Hiroyuki

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Grant amount：\4810000 （ Direct expense: \3700000 、 Indirect expense：\1110000 ）

Postoperative scar tissue on palates is considered to induce maxillary growth inhibition in cleft lip and palate patients. We characterized the role of TRP channels in the release of TGF-β1 from keratinocytes and the differentiation of fibroblasts to identify possible promising pharmacological approaches to prevent scar formation and contractures. The 3D culture model was made from rat skin seeded on a collagen gel in which dermal fibroblasts had been embedded. Among the TRP channel inhibitors tested, the TRPV2 inhibitors attenuated most potently keratinocyte-dependent and -independent collagen gel contraction due to TGF-β signaling as well as TGF-β1 release from keratinocytes and α-SMA production in myofibroblasts. TRPV2 was expressed in the epidermis and keratinocyte layers of the model. Compounds targeting TRPV2 channels would ameliorate wound contraction through the inhibition of TGF-β1 release and the differentiation of dermal fibroblasts in a culture model.

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Elucidation of the pathogenic mechanism of diabetic nephropathy by oral microorganism-derived blood TLR ligand and development for prevention

Grant number：15H05060 2015.04 - 2018.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

SAWA YOSHIHIKO

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Grant amount：\17680000 （ Direct expense: \13600000 、 Indirect expense：\4080000 ）

Diabetes is known to increase the possibility of becoming nephropathy when it comes to periodontitis, but the mechanism is not known. In an experiment using diabetic mice, we found that blood vessels of a urine generating device, called glomeruli of the kidney, express 'toll-like receptors' that recognize bacterial components when it comes to diabetes. We also found that injection of periodontal disease pathogen into mucosa of diabetic mouse oral cavity causes nephropathy. It is thought that germs of periodontal disease enter the blood vessels of the oral cavity, go around the body, enter the kidney and bind to the receptor and cause nephropathy. In periodontitis, bacteria easily enter the blood vessel with tooth brushing. For people with diabetes, prevention of periodontitis is considered to prevent the diabetic nephropathy.

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Investigation of the influence on oral health of childhood cancer treatment

Grant number：26860834 2014.04 - 2017.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)

Nishimura Sawa, Ishikawa Hiroyuki, Sawa Yoshihiko, Inada Hiroko, Suita Sachiyo

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Grant amount：\3510000 （ Direct expense: \2700000 、 Indirect expense：\810000 ）

This study aimed to investigate the laterality of tooth formation anomalies in pediatric cancers. The 46 long-term survivors treated for pediatric cancers were divided into two groups to analyze for the incidence of tooth agenesis (TA) and microdonts (MO): a conventional chemotherapy (CC, n=26); a high-dose chemotherapy followed by blood stem cell transplantation (HDC, n=20). It was revealed that anti-cancer chemotherapies induce TA/MO more in maxilla than in mandible symmetrically and HDC is prone to induce asymmetrical TA/MO in mandible. The mandible is a free bone supplied by the inferior alveolar artery whereas the maxilla is a complex supplied by the sphenopalatine artery, posterior and anterior superior alveolar arteries, and greater palatine artery. It is thought that anti-cancer treatments affect tooth buds stronger in maxilla than in mandible based on the blood supply, and the laterality of blood supply may induce the laterality of TA/MO.

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The promotion mechanisms of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors in glomerular endothelial cells.

Grant number：25670803 2013.04 - 2015.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research

SAWA YOSHIHIKO, HATAKEYAMA Yuji, OKA Kyoko

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Grant amount：\3770000 （ Direct expense: \2900000 、 Indirect expense：\870000 ）

We showed that the glomerulus blood endothelial cells with Diabetes mellitus expressed toll-like receptors (TLRs), and that all of the diabetic mice injected with Porphyromonas gingivalis LPS, which is the ligand of TLRs and the causative agent of periodontitis, died for diabetic nephropathy within all survival periods of non-diabetic mice with the LPS likewise. Diabetic nephropathy might be a cause in oral bacteria entering in the circulation because bacteria easily enter into the blood vessels of the patients with severe periodontitis by toothbrushing. The bacteria entering into the circulation at the intestine go to the liver but at the oral and maxillofacial circulation bacteria anatomically reach to kidney. Now, we began the study to prophylactically inhibit diabetic nephropathy by using the TLR antagonists.

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Chimeric PLAG-immunoglobulin protein-induced anti-tumor immune response

Grant number：23659884 2011 - 2012

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research

SAWA Yoshihiko, KATO Yukinari, TANIGUCHI Kunihisa, TSURUGA Eichi, HATAKEYAMA Yuji, OKA Kyoko

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Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）

We developed novel rat antibodies specific for human and mouse podoplanin (NZ-1.2, PMab-1) sold by MBL, Imgenex, Sigma, and Millipore. The antibodies suppressed the growth of podoplanin positive tumor cells transplanted under mouse buccal mucosa and the effect enhanced in mice immunized with podoplanin peptide. Podoplanin may useful molecule for immunotherapy of cancer.

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唾液腺筋上皮形態形成におけるRhoGTPaseの役割

2010 - 2012

科学研究費補助金

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Grant type：Competitive

唾液腺筋上皮形態形成はRhoが担う

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Induction of carcinogenesis in oral cancer cells by CLEC2-PLAG complex in the lymphatic microcirculation

2010 - 2012

Grant-in-Aid for Scientific Research

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Grant type：Competitive

Induction of carcinogenesis by CLEC2-PLAG complex

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Functional analysis of Rho-GTPase playing the re-arrangement of cytoskeleton in salivary gland epithelial cells

2010 - 2012

Grant-in-Aid for Scientific Research

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Grant type：Competitive

Functional of Rho in salivary gland epithelial cells

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Role of podoplanin in the differentiation of developmental odontoblasts

2010 - 2012

Grant-in-Aid for Scientific Research

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Grant type：Competitive

Role of podoplanin in developmental odontoblasts

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リンパ管内微小環境におけるCLEC2-PLAG 複合体の癌性形質誘導に関する研究

2010 - 2012

科学研究費補助金

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Grant type：Competitive

悪性腫瘍の転移機構

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Effects of alkylating agents to the tooth germ development

2010 - 2012

Cooperative Research

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Grant type：Competitive

Alkylating agents diminish tooth germ

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歯胚象牙芽細胞の分化機構で果たす内皮細胞由来シアル酸蛋白の寄与

2010 - 2012

科学研究費補助金

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Grant type：Competitive

象牙芽細胞の形態分化

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アルキル化剤が歯胚形成に及ぼす影響

2010 - 2012

共同研究

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Grant type：Competitive

アルキル化剤は歯胚を欠損させる

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CLEC2-PLAG complex-induced oncogenic transformation in the intra-lymphatic microenvironment

Grant number：22390345 2010 - 2012

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

SAWA Yoshihiko, KATO Yukinari, TANIGUCHI Kunihisa, TSURUGA Eichi, KAJIYA Hiroshi, HATAKEYAMA Yuji, OKA Kyoko

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Grant amount：\19890000 （ Direct expense: \15300000 、 Indirect expense：\4590000 ）

We developed novel antibodies specific for human and mouse podoplanin (PMab-1,NZ-1.2) sold in MBL, Imgenex, Sigma, and Millipore. Immunohistochemical studies on the oral squamous cell carcinoma (SCC) revealed that platelets exist between SCC and lymphatic endothelial cells at the luminal side of lymphatic vessels where SCC attached. The platelets may contribute to the lymphogenous metastasis of SCC. The adhesion activity to human lymphatic endothelial cells was higher in podoplanin-positive SCC than in podoplanin-negative SCC, and the adhesion of SCC was blocked by NZ-1.2. Anti-podoplanin may be useful for the inhibition of the lymphogenous metastasis of SCC.

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The basic study of effects of bFGF on control of post-operative scarring in cleft palate surgery

Grant number：20390526 2008 - 2011

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

ISHIKAWA Hiroyuki, SAWA Yoshihiko, TSURUGA Eichi, TANIGUCHI Kunihisa, HATA Yuichiro

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Grant amount：\18850000 （ Direct expense: \14500000 、 Indirect expense：\4350000 ）

The pharmaceutical modulation may reduce unfavorable effects of scarring after cleft palate surgery by the push-back method. This study investigated the effects of local bFGF administration immediately after mucoperiosteal denudation of rat palates on apoptosis in myofibroblasts, collagen changes and dento-alveolar growth during the wound healing. The results showed that bFGF induces rapid reductions in myofibroblasts, suppresses collagen typeIand elastic system fibers generation, and relieves dental arch constriction in the wound healing process after mucoperiosteal denudation of rat palates. These findings suggest that bFGF has the potential to reduce maxillary growth inhibition after cleft palate surgery by modulating the palatal wound healing process.

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The Clarification of the expression mechanism of functional molecules on human lymphatic endothelium in oral cavity

Grant number：18390483 2006 - 2009

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

YOSHIDA Shigemitsu, ISHISAKI Akira, DOMON Takanori, ASHIKAGA Yuichi, INOUE Kiichiro, KUROSHIMA Shinichiro, SAWA Yoshihiko

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Grant amount：\17560000 （ Direct expense: \15700000 、 Indirect expense：\1860000 ）

We investigated some proteins which play an important role in the immune system to clarify immune mechanisms via intraoral and extraoral lymphatic vessels. We showed that intraoral lymphatic vessels may differently play site-specific roles in immune systems, and extraoral lymphatic vessels have intracellular networks through these proteins. We discovered that systemic lymphatic vessels contribute to not only substance transport, but also immune mechanisms.

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象牙芽細胞におけるデスモプラキンカイネティクスに関する研究

Grant number：16659497 2004 - 2005

日本学術振興会科学研究費助成事業萌芽研究萌芽研究

沢禎彦, 吉田重光, 山岡雄司

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Grant amount：\3400000 （ Direct expense: \3400000 ）

本年度は、前年度に報告した以下の事柄に関して追試を行った。すなわち、ヒト歯髄象牙芽細胞におけるデスモゾーム蛋白の発現に関して、
1.ヒト歯髄象牙芽細胞はデスモプラキン-1、-2、プラコグロビン、デスモコリン-1、-2、-3、デスモグレイン-1、-2、-3のうち、デスモプラキンのみを発現する。
2.ヒト歯髄におけるプラキンファミリー蛋白の発現はデスモプラキンのみが特異的である。
3.デスモプラキンは象牙芽細胞の細胞体および細胞突起全体に拡散して発現する。
4.培養歯髄細胞ならびに象牙芽細胞では、デスモプラキンおよびプラコグロビン遺伝子を発現する。
5.培養歯髄細胞ならびに象牙芽細胞では、デスモコリン-1、-2、-3およびデスモグレイン-1、-2、-3の遺伝子を発現しない。
6.培養歯髄細胞ではデスモプラキン蛋白の発現は見られない。
7.分化培地を用いた培養でオステオカルシンおよびデンチンシアロホスホプロテインの遺伝子発現が陽性となった細胞ではデスモプラキン-1蛋白の発現が見られる。
8.オステオカルシンおよびデンチンシアロホスホプロテインの遺伝子発現が陽性となった細胞ではデスモプラキン蛋白に対するビメンチンの結合が見られる。
以上の研究成果は、デスモゾーム蛋白デスモプラキンがヒト歯髄象牙芽細胞の分化マーカーとなる可能性、また象牙芽細胞は通常のデスモゾームを形成しない可能性、さらに象牙芽細胞において、デスモプラキンはビメンチンと結合することで細胞内骨格分子として機能する可能性を示唆するものである。

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THE STUDY FOR REGULATION OF THE DEVELOPMENTAL DYNAMICS OF LYMPHATIC SYSTEMS IN HEAD AND NECK, AND FOR THE ADHESION SYSTEMS OF CANCER CELLS TO LYMPHATIC ENDOTHELIUM

Grant number：14370575 2002 - 2005

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

YOSHIDA Shigemitsu, SAWA Yoshihiko, SHIBATA Kei-ichiro, YAMAOKA Yuji

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Grant amount：\13900000 （ Direct expense: \13900000 ）

We have been cleared that the human lymphatic endothelium expresses desmoplakin which is a component of desmosome. In this study, the expression of desmosome-associated proteins ; desmoplakins and plakoglobin in plaque, and desmocollins and desmogleins in core was tested on the oral squamous cell carcinoma (OSCC) in the maxillary antrum and tongue. In the results, 1)lymphatic endothelium in cancer tissues expressed desmoplakins, 2)OSCC in lymphatic vessles overexpressed desmoplakins, and 3)OSCC developed a tendency to lose desmosomal core. In the study for the expression of desmosomal proteins on OSCC cell lines ; HSC2,HSC3,HSC4,HO1myu1,HO1N1,Ca.922,SAS,KB, it was observed that 1)all cell lines did not express desmoglein 1 and 2, 2)KB did not express desmoglein 1-3, 3)all cell lines except for Ca.922 did not express desmocollin 1, 4)HSC4,HO1myu1,HO1N1,SAS rarely express desmocollin 2, 5)all cell lines express desmocollin 3, plakoglobin, and desmoplakin 1 and 2, and 6)in HO1myu1,HO1N1,Ca.922, and SAS, desmoplakin expresses at cell-cell contact but in HSC2,HSC3, and HSC4, desmoplakin diffuses intracellularly. The OSCC may bind to lymphatic vessels with surface exposed desmoplakin overexpressed on cells. Furthermore the OSCC cells in both cell lines and tissues having p53 mutant also intracellulaly overexpressed desmoplakin. The over-expression of desmoplakin may be implicated of the p53 mutation. In the cell growth test for the human neonatal lymphatic endothelial cells (HNDLEC), it was showed that HNDLEC could not proliferate without vascular endothelium growth factor (VEGF) and insulin-like growth factor (IGF). The proliferative test of HNDLEC in co-culture with HSC2,HSC3,HSC4,HO1myul,HO1N1,Ca.922,SAS, and KB, it was suggested that the maintenance of cell viability of HNDLEC is longer in co-culture with HSC3, HO1myu1, SAS than in culture without them. Some OSCC may produce the growth factors which need to the lymphatic angiogenesis.

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THE STUDY FOR ADHESION SYSTEMS OF LYMPHOCYTES AND CANCER CELLS TO LYMPHATIC ENDOTHELIUM

Grant number：12470379 2000 - 2003

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)

SAWA Yoshihiko, YAMAOKA Yuji, YOSHIDA Shigemitsu

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Grant amount：\15500000 （ Direct expense: \15500000 ）

On the adhesion systems of cancer cells to lymphatic vessels we showed that desmoplakin is a specific marker for lymphatic endothelium (Ebata et al., 2001a, b). We are now investigating whether desmoplakin aids the adhesion of oral squamous cell carcinoma to lymphatic endothelium. On the adhesion systems of lymphocytes to lymphatic vessels we examined the expressions of cys-cys (C-C) chemokine ligand 21 (CCL21) expressing in secondary lymphoid tissues, and of toll-like receptor (TLR)2 and TLR4, using human small intestine. These expressions were not clearly detected on collecting lymphatic vessels but the expression of TLRs 2 and 4 was observed on the central lacteals and lymphatic capillaries expressing CCL21 in the lamina propria mucosae whereas the expression of CCL21 and TLRs was not clearly observed in blood vessels (Kuroshima et al., 2004a). The TLRs sense pathogen-associated molecular patterns (PAMPs) and induce cytokine production. Our results suggests that the expression of CCL21, and TLRs 2 and 4 is predominantly induced in the peripheral lymphatic endothelium of the small intestinal microcirculation, and that the lymphatic endothelium may contribute to allow lymphocytes to home into secondary lymphoid tissue through the expression of TLRs, PAMPs engagements of which result in the chemokine induction. In uninflamed human gingiva the CCL21 expression was detected on all lymphatic capillaries of the mucosal connective tissue papillae while there were two types of collecting lymphatic vessels expressing CCL21 or not. In inflamed gingiva no CCL21 expression was detected on lymphatic vessels. No blood vessels expressed CCL21. These results may suggest that the CCL21 expression is predominantly induced in the peripheral lymphatic endothelium of the uninflamed mucosal microcirculation of gingiva, and that under inflamed conditions a reduction of CCL21 occurs in lymphatic endothelium (Kuroshima et al., 2004b).

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歯根膜組織の老化機構に関する研究

Grant number：12877301 2000 - 2001

日本学術振興会科学研究費助成事業萌芽的研究萌芽的研究

沢禎彦, 山岡雄司, 吉田重光

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Grant amount：\1800000 （ Direct expense: \1800000 ）

本年度は,ヒト培養歯根膜細胞のテロメア長分析を行った.その結果,1)1回の分裂で切れるテロメア長は150bpで,50-100bp/回という従来の報告とほぼ一致した.2)平均的テロメア長は表皮線維芽細胞の平均的テロメア長である16kbpより短かった.3)ドナー年齢に相関したテロメア短小化は観察されなかった.4)同一のドナー由来の歯根膜組織から,平均3kbpの短いテロメア長を有する株と,平均13kbpの長いテロメア長を有する株が,またその両者をカバーする範囲のテロメア長を示す株が確立された.本結果から,歯根膜線維芽細胞は年齢に相関せず一般的に短いテロメアを有することが示唆され,表皮など他の一般的結合組織繊維芽細胞よりも細胞寿命の短い可能性が考えちれた.
一方,歯根膜細胞株のあるものは長いテロメアを示したことから,歯根膜におけるテロメラーゼ活性発現型歯根膜幹細胞の存在を考えた.テロメア長を検索した細胞株について,そのテロメラーゼ活性をTRAPアッセイによって測定し,また免疫染色によってテロメラーゼ蛋白発現を検索した.その結果,1)TRPPアッセイでは,典型的なテロメラーゼ活性を示す結果は得られなかったが,細胞株のテロメア長とは関係なく,弱いテロメラーゼ活性の存在を示唆する増幅されたTRAP産物が観察された.2)抗テロメラーゼ抗体陽性の細胞が観察された.以上について,申請者は現在投稿準備中であり,今後,歯根膜幹細胞の探究と分離を試み,培養歯根膜作製への応用を目標とする基盤研究を申請する.

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歯の再植の成否に関与する歯根膜細胞の活性に関する免疫組織化学的研究

Grant number：11877328 1999 - 2000

日本学術振興会科学研究費助成事業萌芽的研究萌芽的研究

吉田重光, 山岡雄司, 沢禎彦, 牧野修治郎

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Grant amount：\2000000 （ Direct expense: \2000000 ）

1.ヒト歯根膜組織ならびに培養ヒト線維芽細胞におけるGap junction関連蛋白[connexin(Cx)]の発現を検索した結果,歯根膜線維芽細胞はCx43,Cx32を発現すること,培養細胞においてCx43は細胞の辺縁ならびに核周囲に発現し,Cx32は核以外のすべての部位に広く発現することを報告した[北海道歯学雑誌,2000,vol.21,No.1,Tssue ＆ Cell,2000,32(4)].
しかしながら,本研究において発現が認められたCxがGap junctionを形成していることに関しては不明であり,免疫電顕的手法を用いた検索が必要であると考えられるため現在Cxの局在に関して検索中である.
2.ヒト歯根膜組織ならびに培養ヒト線維芽細胞におけるDesmosome関連蛋白の発現を検索した結果,歯根膜線維芽細胞にdesmoplakin, desmogrein, desmocollin Iおよびdesmocollin IIIが存在すること,さらにdesmoplakinとdesmogreinに関しては加齢にともない増加していく可能性があることを報告した[Tissue&Cell,1999,31(6)].これらDesmosome関連蛋白の局在に関して詳細な検討が必要であると考えられたため,培養細胞を免疫電顕によって検索した結果,上記Desmosome関連蛋白ならびにplakoglobinは,細胞膜近傍と分泌顆粒中に存在するものの,培養細胞間にdesmosomeを確認することは出来なかった[北海道歯学雑誌,2000,vol.21,No.1].
現在ヒト歯根膜組織を免疫電顕的手法にてdesmosomeの存在と上記蛋白の発現部位に関して検索している.

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Immuno-histochemical and microbiological study on the relationships between microcirculatory system and immuno-defence system in the dental pulp.

Grant number：09470389 1997 - 2000

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B). Grant-in-Aid for Scientific Research (B).

YOSHIDA Shigemitsu, SAWA Yoshihiko, SHIBATA Kenichiro, WATANABE Tsuguo, YAMAOKA Yuji, MAKINO Shujiroh

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Grant amount：\13500000 （ Direct expense: \13500000 ）

To clarify the relationships between microcirculatory system and immuno-defence system in the dental pulp, we examined human blood and lymphatic vessels immuno-histochemically and microbiologically. The results are summarized as follows :
1)In general, lymphatic vessels in healthy tissue express PECAM-1 only, but in inflamed tissue, they express PECAM-1, ICAM-1, ICAM-3, and VCAM-1.
2) In the submandibular lymph node, lymphatic vessels express PECAM-1 and ICAM-1.
3) In the tongue, lymphatic capillaries close to oral epithelitum express PECAM-1, ICAM-1, and ELAM-1, or PECAM-1 and ICAM-1. However, collecting lymphatic vessels express PECAM-1 only.
4) Mediation of inflammatory cytokines induce strong expression of PECAM-1, and expression of ICAM-1 on the lymphatic vessels.
5) Some oral microbial associates induce expression of leukocyte adhesion molecules and production of cytokines in the vascular endothelial cells.
6) In blood vessels of healthy dental pulp, there are strong expression of PECAM-1 and weak expression of MHC class II, ELAM-1, and ICAM-1.
7) In blood vessels of inflamed dental pulp, there are strong expression of PFCAM-1, MHC class II, ELAM-1, ICAM-1, ICAM-3, and VCAM-1.
8) In lymphatic vessels of healthy and inflamed dental pulp, there are strong expression of PECAM-1 and weak expression of ICAM-1.
9) PECAM-1 expression of the blood vessels was observed only on the luminal surface of the endothelium, but in the lymphatic vessels, it was found both on the luminal and abluminal surfaces of the endothelium.
10) Expression of desmoplakin is observed only in the lymphatic vessels, but not in the blood vessels, indicating that anti-desmoplakin antibody is useful to discriminate lymphatic vessels from blood vessels.

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口腔粘膜症患の発症機構におけるγδT細胞の関与に関する研究

Grant number：09877357 1997 - 1998

日本学術振興会科学研究費助成事業萌芽的研究萌芽的研究

吉田重光, 沢禎彦, 鈴木正嗣, 柴田健一郎

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Grant amount：\1900000 （ Direct expense: \1900000 ）

1. ヒトおよびBALB/cAnNCrjマウスγδT細胞についてのγδT細胞レセプター共通抗原に対する抗体(anti-pan-γδTCR)、およびanti-Vγ4を用いた免疫組織化学的検索
1) 腸管粘膜やリンパ節の組織切片で観察されるγδT細胞の細胞数と比較して、舌ならびに頬粘膜の組織切片で観察されるγδT細胞の細胞数は顕著に少ない。
2) TNF-αならびにIFN-γを投与したマウス舌粘膜では健常組織と比較してγδT細胞の増加は見られない。
3) BCG投与ならびにLPS長期連続投与したマウス舌ではanti-Pan-γδTCR陽性細胞およびVγ4型γδT細胞の両者の増加傾向が見られる。
2. 扁平苔癖および舌癌から得られた臨床材料についてのanti-pan-γδTCRを用いた検索
4) 扁平苔癖病巣中心部ではγδT細胞は観察されないものの、病巣辺縁部ではγδT細胞が観察される。
5) 舌癌では病巣中心部および辺縁部共にγδT細胞は観察されない。
以上の検索結果は、口腔粘膜に通常存在するγδT細胞の細胞数は腸管粘膜ほど多くないこと、急性炎症には関与しないこと、また粘膜異常の早期に出現し、これに関与する可能性のあることを示すものである。またγδT細胞の分化に関与することが知られているIL-7を長期投与したマウス舌組織切片において、観察されるγδT細胞の細胞数が増加傾向を示すことが観察されたが、このことは口腔粘膜における未分化T前駆細胞の存在を示唆している。

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組織内微小リンパ管の免疫学的機能に関する研究

Grant number：09771490 1997 - 1998

日本学術振興会科学研究費助成事業奨励研究(A) 奨励研究(A)

沢禎彦

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Grant amount：\2400000 （ Direct expense: \2400000 ）

申請者は平成10年度において以下の事実を明らかにした。1. ヒト健常組織のリンパ管は、白血球接着因子の中で、PECAM-1のみを発現する。2. ヒトリンパ節皮質辺縁には5'-nucleotidase活性とPECAM-1の発現がともに強い活性化リンパ球が観察される。以上1.2.の結果は、ヒトリンパ管内皮細胞がPECAM-1を介してリンパ球と接着する可能性を示すものである。3. CD4+およびCD8+αβ+T細胞が種々のヒト組織内リンパ管に存在する。4. 多数の血管がMHCclassIIを発現しているヒト炎症組織において、ICAM-1,ICAM-3,PECAM-1および
VCAM-1を発現しているリンパ管が存在する。5. マウスリンパ管は通常ICAM-1を発現しないが、TNF-αおよびIFN-yを腹腔に投与したマウスの腸管膜では、
ICAM-1を発現しているリンパ管が存在する。
以上3.4.5.の結果は、リンパ管は通常PECAM-1のみを発現するが、炎症組織内のリンパ管内皮細胞は種々の白血球接着因子を発現すること、その発現は炎症性サイトカイン依存性に増大することを示唆している。
本研究は、組織内リンパ球の組織からリンパ管内への移動にリンパ管内皮細胞が発現する接着因子が寄与する可能性を示すものである。このことは以後、免疫担当細胞のリンパ循環系のならびに腫瘍のリンパ節転移機構の研究に大きく貢献すると考えられる。

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免疫組織化学的手法による新しいリンパ管同定法の開発

Grant number：08771558 1996

日本学術振興会科学研究費助成事業奨励研究(A) 奨励研究(A)

沢禎彦

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Grant amount：\1100000 （ Direct expense: \1100000 ）

申請者は,これまで安定した結果の得られるヒト組織内微小リンパ管の特異的同定法が確立されていなかったことから、免疫組織化学的方法を用いたヒトリンパ管特異的同定法を開発し(印刷中)、専門学会に報告した(第42回日本解剖学会東北・北海道連合地方会、平成8年9月、山形。第38回歯科基礎医学会、平成8年10月、横須賀)。本方法は、ヒト胸管内皮細胞の膜蛋白特異的抵抗体が、抗ラミニン抗体で強く染色される血管様構造物に反応を示さず、リンパ管様構造物のみを認識することから確立した、抗体ヒト胸管抗体によるヒトリンパ管特異的免疫染色法である。また、抗ヒト胸管抗体でリンパ管を、さらに抗ラミニン抗体で血管を鑑別染色する二重染色法を確立した。本染色法は次の点で画期的であると思われる。1)反応が特異的であり、且つ通常の固定・染色操作で抗原決定基が失活しないことから、安定した血管が得られること。2)入手の容易な市販の抗体を用いた凍結切片に対する方法であることから、病理検査など一般的方法として有用であること。申請者はこれまでその存在に関して種々の論争のあった、ヒト歯髄リンパ管の光顕的同定を行った(投稿中)。また現在、本方法によって同定した種々の組織内微小リンパ管の内皮細胞について、イムノグロブリンスーパーファミリーの発現を検索し、リンパ管内皮細胞の細胞輸送機能を検討している(投稿準備中)。

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歯周病原細菌による糖尿病増悪の仕組み〜プロフェッショナル口腔ケアによる血糖値制御を目指して〜

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福岡県歯科医師会地域保健部 2025.2.1 - 2025.2.28

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