Updated on 2024/10/18

写真a

 
ITO Takehiko
 
Organization
Faculty of Education Professor
Position
Professor
External link

Degree

  • 博士（医学） ( 岡山大学 )

Research Interests

  • School Health and Safety

  • Small area analysis

  • Industrial Health

  • School physician

  • Drug abuse and dependence

  • Prevention of heat related disorders

  • Small area analysis

  • School health and school safety

  • 学校安全

  • Drug abuse prevention

  • Industrial Health

  • Prevention of heat related disorders

Research Areas

  • Life Science / Nutrition science and health science

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Hygiene and public health (laboratory)

Education

  • Okayama University   大学院医学研究科   脳代謝医学(神経化学)

    1989.4 - 1993.3

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    Country： Japan

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  • Okayama University    

    - 1993

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  • Okayama University   医学部   医学科

    1983.4 - 1989.3

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    Country： Japan

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  • Okayama University    

    - 1989

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Research History

  • Okayama University   Graduate School of Education   Professor

    2008.4

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  • Okayama University   Faculty of Education   Professor

    2007.4 - 2008.3

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  • Okayama University   Faculty of Education Training Coruse for School Nurse Teachers   Associate Professor

    1997.4 - 2007.3

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  • University of Mississippi Medical Center   Depatment of Pharmacology and Toxicology   Reasearch Associate

    1993.4 - 1996.5

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  • Okayama University   教育学部附属特別支援学校

    2007.4

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  • Hyogo University of Teacher Education   社会調査研究センター

    2007.4 - 2008.3

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  • Professor,Faculty of Education,Okayama University

    2007 - 2008

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  • Hyogo University of Teacher Education   社会調査研究センター

    2006.4 - 2007.3

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  • Hyogo University of Teacher Education   大学院連合学校教育学研究科

    1999.10 - 2007.3

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  • Associate Professor

    1999 - 2007

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  • University of Tsukuba   大学院 医科学研究科

    1998.4 - 2002.3

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  • Associate Professor,Faculty of Education,Okayama University

    1997 - 2007

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  • Reasearch Associate,University of Mississippi Medical Center

    1993 - 1996

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Professional Memberships

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Committee Memberships

  • 日本公衆衛生学会   代議員  

    2021.7 - 2023.7   

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    Committee type：Academic society

    日本公衆衛生学会

  • 日本公衆衛生学会   代議員  

    2017 - 2019   

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    Committee type：Academic society

    日本公衆衛生学会

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  • 日本安全教育学会第18回岡山大会   実行委員長  

    2016.10 - 2017.9   

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    Committee type：Academic society

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  • 日本産業衛生学会温熱環境研究会   世話人  

    2015   

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    Committee type：Academic society

    日本産業衛生学会温熱環境研究会

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  • 日本学校保健学会   第62回日本学校保健学会年次大会 実行委員長  

    2014 - 2015   

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    Committee type：Academic society

    日本学校保健学会

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  • 岡山スポーツ医科学研究会   幹事  

    2013   

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    Committee type：Academic society

    岡山スポーツ医科学研究会

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  • 日本公衆衛生学会   査読委員  

    2012 - 2017   

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    Committee type：Academic society

    日本公衆衛生学会

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  • 日本産業衛生学会   代議員  

    2005 - 2010   

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    Committee type：Academic society

    日本産業衛生学会

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Papers

  • A Nationwide Survey on the Support System for Students with Special Educational Needs in Correspondence High Schools in Japan Reviewed

    Yuka Tanaka, Munehisa Yoshitoshi, Takehiko Itoh

    Japanese Journal on Developmental Disabilities   43 ( 2 )   214 - 225   2021.8

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  • The effectiveness of Okayama University program during expansion period of COVID-19 infection Reviewed

    Hisao SUZUKI, Yuji KOBAYASHI, Akemi OTA, Isao TAKAMARU, Nobuko KURASAKI, Chihiro EDAMATSU, Masaki SUGA, Atsushi SUMIMOTO, Kayo SHITARA, Tomohiro YASUDA, Kyoko NOGUCHI, Michiko SHO, Reiko NOGAMI, Hiroshi MATSUI, Kohei TAKEDA, Masami MIYAZAKI, Masako MIZUKAMI,Rie SHIOSHIMA, Kyoichi NAKAYAMA, Yu AKIHARA, Hiroki OBATA, Takehiko ITO

    Japanese Journal of Physical Education and Sport for Higher Education   18   49 - 55   2021.3

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  • 子どもたちが快適に学び育つ学校環境の創造と対策

    伊藤武彦

    労働の科学   76 ( 3 )   8 - 16   2021.3

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    Language：Japanese  

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  • A Study on How School Health Activities can be Conducted to Promote the Acquisition of a Healthy Life-style : Health Guidance for Groups that a Yogo Teacher Taught Invited Reviewed

    23 ( 2 )   3 - 16   2020.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • 学校における暑熱環境の改善と快適な学習環境確保への工夫 (特集 地球温暖化と熱中症の予防) Invited

    伊藤 武彦

    労働の科学 = Digest of science of labour   72 ( 4 )   213 - 219   2017.4

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    Language：Japanese   Publisher：大原記念労働科学研究所  

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  • How Yogo Teachers of attached schools get involved in student teaching

    紙川 未央, 本田 浩江, 北原 章江, 古川 育実, 上村 弘子, 伊藤 武彦, 住野 好久, 三村 由香里

    岡山大学教師教育開発センター紀要   5   129 - 138   2015.3

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    Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：岡山大学教師教育開発センター  

    子どもの多様な健康課題に対応して，学校における安全・安心な環境の確保や子どもの心身の健康を守り，はぐくむことのできる体制構築が求められる今日，教育実習等においては，実習生を学校保健に対する関心・理解を高め，子どもの健康・安全な学校生活を考慮した教育活動を展開できる教員として育成することが重要となる。そこで，教育実習等の機会に附属学校園養護教諭が，学校保健活動を遂行できる教員養成を目的とした講義・演習を実施した。その結果，実習生は学校保健に対する認識を高めることができた。附属学校園養護教諭が教員養成に積極的に参画することは，学校保健活動を遂行できる教員養成に果たす役割が大きいといえる。

    DOI： 10.18926/CTED/53243

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  • Characterization of Elementary School Districts : A model study in Himeji City

    伊藤 武彦, 中山 いづみ

    研究集録   ( 158 )   23 - 26   2015.3

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    Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：岡山大学大学院教育学研究科  

    この研究では，小学校の通学区域を国勢調査結果や住民基本台帳データのうち小学校の通学区域（学区）別に編纂されているものを用いてそれらの類型化を試み，その結果を地図上に表現した。そのような類型が生じる背景にある人口学的な性質を考察し，学校ごとに濃淡がある児童生徒の種々の健康課題について，日常生活における背景を考察するためのツールとしての可能性に言及した。

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  • ニジェール共和国における健康教育推進のための教員研修の評価 Reviewed

    上村 弘子, 松枝 睦美, 三村由香里, 伊藤 武彦

    学校保健研究   54 ( 4 )   316 - 329   2012

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本学校保健学会  

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  • Improvement of heat environment of a gymnasium designed for dance lessons

    伊藤 武彦, 鈴木 久雄, 加賀 勝

    Environmental research & control   ( 32 )   8 - 11   2010

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    Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：岡山大学環境管理センター  

    Nowadays,we experience severe hot climate during summer.Ambient temperature and wet bulb globe temperature (WBGT) in our gymnasium designed for dance lessons exceeded exposure limits of both school health and industrial health. Such environment was our direct concern for risk of heat related disorders among students, guests and staffs using the facility. The building was old, and heat insulation seemed to be insufficient compared to recent standards for the building of the same kind. Introduction of a new air conditioning system to the facility was supposed to be avoided according to energy conservation policy. We considered that applying high-albedo paint to the roof would reflex the solar infrared irradiation and block the heat influx, thus lowering the ambient temperature inside the gymnasium. The renovation of the roof resulted in improved ambient temperature and WBGT. We concluded that application of high-albedo paint might be a useful technique to control high ambient temperature in similar buildings and to reduce risk of heat related disorders.

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  • 特別講演 熱中症を科学する ([日本養護教諭教育学会第16回]学術集会報告) Invited

    伊藤 武彦

    日本養護教諭教育学会誌   12 ( 1 )   129 - 133   2009.3

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    Language：Japanese   Publisher：日本養護教諭教育学会  

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  • 大学生の身体活動・運動ステージと歩数の関係 Reviewed

    岡崎勘造, 鈴木久雄, 伊藤武彦, 高橋香代

    ウォーキング研究   13   213 - 219   2009

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  • A simple device to measure and record wet bulb globe temperature for prevention of heat disorders

    伊藤 武彦, 三村 由香里, 鈴木 久雄

    Bulletin of Graduate School of Education, Okayama University   140 ( 140 )   7 - 11   2009

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：岡山大学大学院教育学研究科  

    熱中症予防対策に使用する目的で,湿球黒球温度を自動的に連続して測定･記録できる簡便な装置を試作した｡この装置を本学グラウンドに設置し,2008年夏季の暑熱環境の測定を行った結果に若干の考察を加えて報告した。

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  • The half-life of Ascaris lumbricoides prevalence in Japanese school children. Reviewed

    Carmen Miwa Kurosawa, Takehiko Ito, Jiro Takaki, Bin-Ling Wang, Da-Hong Wang, Tomoko Takigawa, Keiki Ogino

    Acta medica Okayama   62 ( 5 )   303 - 12   2008.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：OKAYAMA UNIV MED SCHOOL  

    In the present study, we examined the dynamic of school-health-based parasite control and the related socio-economic influences. This is an ecological study based on data from 46 prefectures in Japan. The exponential decay of Ascaris lumbricoides prevalence was calculated by iterative least-squares method. Pearson's correlation and multiple linear regression model analysis were performed to assess the associations between the prevalence of Ascaris lumbricoides in Japanese school children and socio-economic variables such as the prefecture income per capita, the percentage of primary industry, the population density per 1 km2, the diffusion rate of population under water supply, and the percentage of upper secondary school enrollment. The results indicated that the parasite carrier rate was higher in younger students. The half-life of Ascaris lumbricoides prevalence was approximately 3 years with significant variation among prefectures. Multiple regression analyses showed that the decrease of infection in elementary and lower secondary school children had a significant positive association with primary industry and a significant negative association with prefecture income per capita. The school-health-based parasite intervention differs by prefecture and has changed over time according to the respective prefectural stage of economic development.

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  • 保健医療情報の地図表示システムの構築 Invited Reviewed

    伊藤武彦, 関 明彦, 吉良尚平

    厚生の指標   50 ( 15 )   19 - 25   2003.12

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：厚生統計協会  

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  • 岡山県下における診療科目別医療施設の分布と年次推移 Invited Reviewed

    関 明彦, 伊藤武彦, 吉良尚平

    厚生の指標   49 ( 11 )   10 - 16   2002.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：厚生統計協会  

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  • Obesity and the risk of diabetes mellitus in middle-aged Japanese men. Reviewed

    Akihiko Seki, Tomoko Takigawa, Takehiko Ito, Etsuko Fukuoka, Kayo Takahashi, Shohei Kira

    Acta medica Okayama   56 ( 5 )   255 - 60   2002.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：OKAYAMA UNIV MED SCHOOL  

    The morbidity of diabetes mellitus is increasing gradually in Japanese populations. It is important to clarify the risk factors of diabetes in Japanese populations in order to take adequate measures against the increasing morbidity of diabetes. In order to evaluate the link between past and concurrent obesity and diabetes in middle-aged Japanese men, we conducted a worksite-based historical cohort study in Okayama, Japan in 1999. Annual health examination data of middle-aged male workers in a worksite were collected. The relative risks of past and concurrent obesity for developing diabetes were calculated. Subjects with a past history of obesity at between 40 and 50 years of age had a significantly higher risk of developing diabetes by age 55 than did subjects in the normal weight group. These results suggest that, in order to prevent diabetes in middle-aged Japanese men, health guidance for normal weight maintenance should be provided not only for middle-aged men, but also for men under age 40.

    DOI： 10.18926/AMO/31704

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  • Distribution of inhaled m-Xylene in rat brain and its effect on GABA(A) receptor binding Reviewed

    T Ito, K Yoshitome, T Horike, S Kira

    Journal of Occupational Health   44 ( 2 )   69 - 75   2002.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPAN SOC OCCUPATIONAL HEALTH  

    Organic solvents generally depress the central nervous system (CNS), similarly to volatile anesthetics. The precise mechanism of their action on the CNS, however, is not fully understood, and remains to be clarified. This study is focused on how inhaled m-xylene distributes in the brain, and whether region specific change in GABA A receptor binding takes place due to the exposure. To conduct this study, we first developed a simple exposure system suitable for inhalation experiments with small animals. Using this system, six-week-old male Sprague-Dawley rats were exposed to m-xylene vapor (2000 ppm) 4 h/d, for 5 consecutive days. At the end of the exposure, m-xylene levels in four different regions of the brain were measured by head-space gas chromatography. Also 14 mum-thick frozen sections of the brain were made, and [S-35] t-butylbicyclophosphorothionate (TBPS) binding autoradiography was performed. Uneven distribution of m-xylene in the brain was observed. The concentration in the cerebellum (976+/-93.4 mug/g tissue) was the highest, while that in the cerebral cortex (467+/-43.6 mug/g tissue) was the lowest. [S-35]TBPS binding was significantly greater in the molecular layer of the cerebellum (control: 12.6+/-0.64, m-xylene 16.0+/-1.34 fmol/mg tissue). These results suggest that m-xylene is distributed unevenly in the rat brain, and acute exposure to m-xylene at a high concentration alters [S-35]TBPS binding, which may reflect changes in GABA A receptor characteristics.

    DOI： 10.1539/joh.44.69

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  • Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain Reviewed

    S Abe, T Suzuki, T Ito, M Yamaguchi, A Baba, T Hori, H Kurita, H Shiraishi, N Okado

    Neuropsychopharmacology   25 ( 2 )   173 - 184   2001.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

    Recent animal studies regarding phencyclidine (PCP), which induces psychotic symptoms in humans, have suggested that g-roup II metabotropic glutamate receptors (mGluRs) represent a novel target for the treatment of PCP psychosis. In the present study, we used in situ hybridization to investigate the gene expressions of the mGluR 1-5 subtypes following single and repeated administration of PCP in rats. A single administration Of PCP (7.5mg/kg, i.p.,) resulted in a significant decrease in the mGluR5 inRNA expression of group I inGluR in the subcortical regions (thalamus (-15%), central gray (-23%), inferior colliculus (-23%), and nucleus accumbens (-10%)) and hippocampal formation (CA1 (-14%), CA2 (-15%), CA3 (-18%), and dentate gyrus (-18%)). After repeated PCP administration for 14 days,, the mGluR2 inRNA expression of group II inGluR in the anterior cingulate cortex (-23%) and the mGluR4 mRNA expression of group III mGluR in the cortical regions (parietal (-11%), temporal (-13%) and entorhinal cortices (-18%)), the caudate putamen (-12%), thalamus (-17%), and subiculum (-25%) were significantly decreased. These results indicate that PCP affects not only group II mGluR but also group I and III of mGluR, and it is of particular interest that mGluR2 subtype is involved in a development of behavioral abnormality following repeated PCP administration. Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain. [Neuropsychopharmacology 25:173-184,2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

    DOI： 10.1016/S0893-133X(00)00250-5

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  • Effects of cocaine administration on receptor binding and subunits mRNA of GABA(A)-benzodiazepine receptor complexes Reviewed

    T Suzuki, S Abe, M Yamaguchi, A Baba, T Hori, H Shiraishi, T Ito

    SYNAPSE   38 ( 2 )   198 - 215   2000.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-LISS  

    The effects of intermittent intraperitoneal (i.p.) administration of cocaine (20 mg/kg) on GABA(A)-benzodiazepine (BZD) receptors labeled by t-[S-35]butylbicyclophosphorothionate (TBPS), and on several types of mRNA subunits were investigated in rat brain by in vitro quantitative receptor autoradiography and in situ hybridization. Phosphor screen imaging with high sensitivity and a wide linear range of response was utilized for imaging analysis. There was a significant decrease in the level of alpha 1, alpha 6, beta 2, beta 3, and gamma 2 subunits mRNA, with no alteration of [S-35]TBPS binding in any regions in the brain of rats at 1 h following a single injection of cocaine. In chronically treated animals, the mean scores of stereotyped behavior were increased with the number of injections, The level of beta 3 subunit mRNA was decreased in the cortices and caudate putamen, at 24 h after a final injection of chronic administrations for 14 days. In the withdrawal from cocaine, the frontal cortex and hippocampal complexes showed a significant increase in [S-35]TBPS binding and alpha 1 and beta 3 subunit mRNA in the rats 1 week after a cessation of chronic administration of cocaine; These findings suggest that the disruption of GABA(A)-BZD receptor formation is closely involved in the development of cocaine-related behavioral disturbances. Further studies on the physiological functions on GABA(A)-BZD receptor complex will be necessary for an explanation of the precise mechanisms underlying the acute effects, development of hypersensitization, and withdrawal state of cocaine. (C) 2000 Wiley-Liss, Inc.

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  • Measurement of benzo(a)pyrene in sea water and in mussels in the Seto Inland Sea, Japan Reviewed

    S Kira, T Katsuse, Y Nogami, T Ito

    Billetin of Environmental Contamination and Toxicology   65 ( 5 )   631 - 637   2000.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER-VERLAG  

    DOI： 10.1007/s001280000170

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  • Time-course effects of a single administration of cocaine on receptor binding and subunit mRNAs of GABA(A) receptors Reviewed

    Mika Yamaguchi, Toshihito Suzuki, Shuzo Abe, Atsuomi Baba, Takehiko Ito, Nobuo Okado

    Molecular Brain Research   81 ( 1-2 )   155 - 163   2000.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

    We investigated the time-course effects of a single administration of cocaine (20 mg/kg) on GABA(A) receptor binding labeled by t- [35S]butylbicyclophophorothionate (TBPS) and on several types of GABA(A) receptor subunit mRNAs in the rat brain by in vitro quantitative receptor autoradiography and in situ hybridization. The levels of α1, β2, and β3 subunit mRNAs in several brain regions such as the cortex, cerebellum, and striatum were significantly decreased within 1 h, while β3 subunit mRNA was increased in the dentate gyrus. All of these changes were transient, occurring within 1 h after the injection of cocaine. In the cortex and cerebellum, the reduction in α1 subunit mRNA was followed by a significant decrease in [35S]TBPS receptor binding, which occurred 4 h after cocaine injection. These findings suggest that acute cocaine administration discretely regulates GABA(A) receptor subunit mRNA levels in several brain regions through a change in transcription or turnover rates of subunit mRNAs, which may be closely related to cocaine-induced behavioral abnormalities. (C) 2000 Elsevier Science B.V.

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  • Improved blue rayon hanging technique that can measure a time-weighted average concentration of benzo(a)pyrine in sea water Reviewed

    S. Kira, H. Horiguchi, Y. Nogami, T. Komatsu, K. Fujisawa, T. Ito, H. Hayatsu

    Bulletin of Environmental Contamination and Toxicology   59 ( 6 )   941 - 947   1997.12

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  • Oxidative stress alters arginine metabolism in rat brain: effect of sub-convulsive hyperbaric oxygen exposure. Reviewed International journal

    T Ito, K Yufu, A Mori, L Packer

    Neurochemistry international   29 ( 2 )   187 - 95   1996.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Ltd  

    The effect of hyperbaric oxygenation on arginine metabolism was investigated. Rats were exposed to oxygen at 3 atmospheres absolute for 2 h. Under these conditions, lipid peroxidation and activation of the anti-oxidant system were observed. Levels of thiobarbiturate reactive substances and carbon-centered radicals were increased in the cerebral cortex, while superoxide dismutase activity was also increased in the mitochondrial and cytosolic fraction of cerebrocortical homogenates. This suggested that the increase of both Mn and Cu,Zn-superoxide dismutase activities was probably an early compensatory reaction to oxidative stress. Levels of arginine as well as its metabolite, guanidinoacetic acid, were increased in the cerebral cortex. This increase seemed to be, at least in part, explained by a decrease in the arginase activity in the same region. Moreover, arginase activity in the brain showed heterogeneous distribution. Arginine: glycine amidinotransferase activity was decreased in the pons-medulla oblongata. The observed effects of hyperbaric oxygenation seem to favor nitric oxide generation.

    DOI： 10.1016/0197-0186(95)00119-0

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  • Pharmacology of barbiturate tolerance/dependence: GABA(A) receptors and molecular aspects Reviewed

    T Ito, T Suzuki, SE Wellman, IK Ho

    Life Sciences   59 ( 3 )   169 - 195   1996.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

    Barbiturates are central nervous system depressants that are used as sedatives, hypnotics, anesthetics and anticonvulsants. However, prolonged use of the drugs produces physical dependence, and the drugs have a high abuse liability. The gamma-aminobutyric acid, (GABA(A)) receptor is one of barbiturates' main sites of action, and therefore it is thought to play a pivotal role in the development of tolerance to and dependence on barbiturates. Recent advances in the study of the GABA(A) receptor/chloride channel complex allow us to examine possible mechanisms that underlie barbiturate tolerance/dependence in a new light. In this minireview, we mainly focus on molecular and cellular aspects of the action of barbiturates and the possible mechanisms that contribute to development of tolerance to and dependence on barbiturates.

    DOI： 10.1016/0024-3205(96)00199-3

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  • Chronic pentobarbital administration alters gamma-aminobutyric acidA receptor alpha 6-subunit mRNA levels and diazepam-insensitive [3H]Ro15-4513 binding. Reviewed International journal

    T Ito, T Suzuki, S E Wellman, I K Ho

    Synapse (New York, N.Y.)   22 ( 2 )   106 - 13   1996.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-Liss Inc.  

    In order to study the chronic effects of pentobarbital, a positive GABAA receptor modulator, on the inverse agonist binding of the benzodiazepine site, binding of [3H]Ro15-4513 and levels of GABAA receptor alpha 6-subunit mRNA were investigated in the brains of pentobarbital-tolerant/dependent animals, using receptor autoradiography and in situ hybridization histochemistry in consecutive brain sections. Pentobarbital was administered to rats either 60 mg/kg, i.p., once, for acute treatment, or 300 micrograms/10 microliters/h i.c.v. continuously for 6 days via osmotic minipumps to render rats tolerant to pentobarbital. Rats assigned to the dependent group were sacrificed 24 h after discontinuance of pentobarbital infusion, while those assigned to the tolerant group were sacrificed at the end of infusion. The alpha 6 subunit mRNA was increased in the tolerant group only. Diazepam-insensitive [3H]Ro15-4513 binding was increased in the cerebellar granule layer of pentobarbital-tolerant and -dependent rats. No alterations in these parameters were observed in acutely treated animals. These data suggest that chronic pentobarbital treatment induced expression of alpha 6-subunit mRNA. This was in contrast to alpha 1- and gamma 2-subunit mRNA, which in tolerant animals are unchanged, but for which withdrawal triggers a surge in levels. Because the alpha 6-subunit is a major component of the diazepam-insensitive [3H]Ro15-4513 binding site, the increased diazepam-insensitive [3H]Ro15-4513 binding implied de novo synthesis of the receptor subunit protein.

    DOI： 10.1002/(SICI)1098-2396(199602)22:2<106::AID-SYN3>3.0.CO;2-H

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  • A novel quantitative receptor autoradiography and in situ hybridization histochemistry technique using storage phosphor screen imaging. Reviewed International journal

    T Ito, T Suzuki, D K Lim, S E Wellman, I K Ho

    Journal of neuroscience methods   59 ( 2 )   265 - 71   1995.7

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    A new technique of image acquisition for quantitative receptor autoradiography and in situ hybridization histochemistry was developed using storage phosphor screen imaging. This method was at least 4-5 times faster than conventional film densitometry. Two of the advantages of the phosphor screen method are high sensitivity and wide linear range of response. Other aspects of this method were compared with those of conventional densitometry. Use of storage phosphor screen imaging will allow greatly increased speed of pharmacological screening procedures that utilize quantitative autoradiography.

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  • A study of the experiences of sexual minorities in sex education at school Reviewed

    Marie WADA, Takehiko ITO

    Adolescentology   40 ( 2 )   232 - 243   2022.6

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  • 学校保健と地域の連携～小山町の実践に学ぶ連携・協働の重要性～

    東亜里紗, 遠藤彩華, 高田真帆, 徳永百合, 濱田芽生, 伊藤恵子, 伊藤武彦

    おかやま保健福祉研究   23   72 - 75   2017.1

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  • カタラーゼ遺伝子を指標とした有害化学物質に対するリスク評価法の開発(第3報)

    堀田 昌子, 汪 達紘, 益岡 典芳, 伊藤 武彦, 関 明彦, 山本 秀樹, 吉良 尚平

    日本衛生学雑誌   60 ( 2 )   256 - 256   2005.3

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  • カタラーゼ遺伝子を指標とした有害化学物質に対するリスク評価法の開発(第2報)

    堀田 昌子, 汪 達紘, 益岡 典芳, 伊藤 武彦, 関 明彦, 山本 秀樹, 瀧川 智子, 吉良 尚平

    日本衛生学雑誌   59 ( 2 )   165 - 165   2004.3

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  • カタラーゼ遺伝子の変異を指標とした有害化学物質に対するリスク評価法の開発(第1報)

    堀田 昌子, 汪 達紘, 益岡 典芳, 伊藤 武彦, 関 明彦, 山本 秀樹, 中山 祥嗣, 瀧川 智子, 吉良 尚平

    日本衛生学雑誌   58 ( 1 )   197 - 197   2003.3

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  • Elevation of antioxidant potency in mice brain by low-dose X-ray irradiation and its effect on Fe-NTA-induced brain damage Reviewed

    Kiyonori Yamaoka, Shuji Mori, Takaharu Nomura, Takehito Taguchi, Takehiko Ito, Katsumi Hanamoto, Shuji Kojima

    Physiological Chemistry and Physics and Medical NMR   34 ( 2 )   119 - 132   2002

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    The increase in lipid peroxide levels in mice brain following Fe 3+ administration was about 50% of that when 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) was administered. This may be due to excessive oxidation by Fe3+, and was supported by the decrease in activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), Na+,K+-ATPase activity and membrane fluidity after Fe3+ administration. Relatively low-dose X-ray irradiation (0.5 Gy) inhibited lipid peroxidation associated with Fe 3+ administration and restored the decreased activities of the above antioxidant enzymes and Na+K+-ATPase, and membrane fluidity to the levels in the non-Fe3+-administered group. In the purine metabolism system, uric acid decreased after Fe3+ administration, which may be due to transient impairment of the system for production of uric acid from xanthine by excessive oxidation by Fe3+. However, 0.5 Gy irradiation inhibited this decrease in uric acid, increasing its level to that in the non Fe3+-administrated group. This may be due to factors such as rapid recovery of the activities of the above antioxidant enzymes and Na+,K+-ATPase, and membrane fluidity after 0.5 Gy irradiation. In addition, since no changes were observed in xanthine and uric acid, increased inosine and hypoxanthine may have advanced to a salvage pathway leading to not xanthine but inosine 5′-monophosphate (IMP).

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  • 国勢調査メッシュ統計データの表示・分析システムの構築 Reviewed

    関 明彦, 伊藤武彦, 松田咲子, 吉田秋子, 井上康二郎, 関 英一, 中林圭一, 吉良尚平

    厚生の指標   48 ( 6 )   8 - 14   2001.6

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  • Benzo(a)pyrene adsorbed to suspended solids in fresh water Reviewed

    Y Nogami, R Imaeda, T Ito, S Kira

    Environmental Toxicology   15 ( 5 )   500 - 503   2000.12

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    The solubility of benzo(a)pyrene (BaP) in water is small, and measured total BaP concentration (t-BaP) in fresh water is the sum of BaP dissolved in water (d-BaP) and BaP adsorbed to suspended solids (p-BaP). We have collected fresh water samples in a lake and rivers in Okayama Prefecture, Japan, and measured both d-BaP and p-BaP in each sample. The blue rayon method or solid-liquid extraction was used for extraction of BaP in water or in suspended solids, respectively. The measurement of BaP was done using high-performance liquid chromatography according to our previously reported method. The present data indicate that p-BaP was about 1.5 to 5 times higher than d-BaP. In general, the amount of suspended solids in each sample did not show a correlation to p-BaP. These results suggest that BaP adsorbed to suspended solids must be taken into account when assessment of t-BaP is done in any given fresh water sample. (C) 2000 by John Wiley & Sons, Inc.

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  • Differential expression of GABA(A) receptor subunit mRNAs and ligand binding sites in rat brain following phencyclidine administration Reviewed

    S Abe, T Suzuki, T Ito, A Baba, T Hori, H Kurita, M Yamaguchi, H Shiraishi

    Synapse   38 ( 1 )   51 - 60   2000.10

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    Recent biochemical observations have suggested the abnormalities in the gamma-amino-butyric acid (GABA)ergic system in schizophrenic brains. In the present study, we investigated the subunits gene expressions and ligand binding of the GABA(A) receptor following acute and chronic administration of phencyclidine (PCP), which induces schizophrenia-like symptoms, in rats using in situ hybridization and in vitro quantitative autoradiography. PCF i.p. administration at a daily dose of 7.5 mg/kg resulted in a significant decrease in expression of alpha 1 subunit mRNA in cerebral cortices (cingulate (-13%) and temporal cortex (-6%)) and hippocampal formation (CA1 (-11%), CA2 (-10%), CA3 (-11%) and dentate gyrus (-1.2%)) 1 h after a single treatment. In the repeated PCP administrations for 14 days, the expression of beta 2 mRNA in the cerebellum (-10%) and of beta 3 mRNA in the cerebral cortices (cingulate (-12%), parietal (-16%) and temporal cortex (-16%), caudate putamen (-18%), inferior colliculus (-18%), and cerebellum (-15%) were significantly decreased. In addition, [S-35] t-butylbicyclophosphorothionate (TBPS) binding was also reduced in layer IV of the frontoparietal cortex (-14%), inferior colliculus (-17%), and cerebellum (-12%) following chronic PCP treatment, while no changes were observed following acute PCP treatment. These results indicate that single and repeated administrations of PCP independently regulate the expression of GABA(A)/benzodiazepine (BZD) receptor subunits mRNA and its receptor binding in the brain. Synapse 38:51-60, 2000. (C) 2000 Wiley-Liss, Inc.

    DOI： 10.1002/1098-2396(200010)38:1<51::AID-SYN6>3.0.CO;2-A

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  • Effects of single and repeated administration of cocaine on NMDAR1 and mGluR5 subunits of glutamate receptors in rat brains Reviewed

    M Yamaguchi, T Suzuki, S Abe, A Baba, H Shiraishi, T Ito

    FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA   ( 1200 )   105 - 106   2000

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    The effects of single and repeated administration of cocaine on mRNA subunits of glutamate receptors were investigated in the rat brain by in situ hybridization. A significantly increased level of NMDAR1 subunits mRNA in the hippocampus was seen 1hr after a single injection of cocaine. Repeatedly treated-rats showed a decreased level of NMDAR1 subunit mRNA in the cortices, striatum, nucleus accumbens and ventral pallidum, and an increased level in the dentate gyrus 24 hrs after a final injection of chronic administration. During cocaine withdraw al, thecortes, striatum, hippocampus and cerebellum showed a significantly decreased level of NMDAR1 and mGluR5 subnuit mRNAs. These findings suggest that a reduction in glutamate receptor subunit mRNA level may reflect a compensatory don:regulation related to enhanced glumate transmission during sensitized and withdrawal state.

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  • Effects of single and repeated phencyclidine administration on the expression of subunit mRNA for NMDA receptors in rat brain Reviewed

    S Abe, T Suzuki, M Yamaguchi, A Baba, H Shiraishi, T Ito

    FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA   ( 1200 )   103 - 104   2000

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    To investigate the effects of phencyclidine (PCP) on N-methyl-d-aspartate (NMDA) receptors, we examined the effects of both single and repeated administrations of PCP on the NMDA receptor subunits in rat brain using in situ hybridization. Intraperitoneal (i.p.) administration of a daily dose of 7.5mg/kg PCP resulted in significantly decreased in expression of NMDAR2A subunit mRNA in the cingulate cortex Ih after a single administration. Repeated PCP administrations for 14 days resulted in significantly decreased the expression of NMDAR1(-) mRNA in the nucleus accumbens and piriform cortex. These results suggest that region-specific decreases of NMDA receptor subunits may represent a compensatory response to enhanced glutamate availability in the limbic region.

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  • Detection of benzo(a)pyrene and mutagenicity in water of Lake Baikal (Russia) and rivers in Okayama (Japan) using the blue rayon method: A simplified handling and transportation of samples from remote sites Reviewed

    S Kira, Y Nogami, T Ito, H Hayatsu

    Environmental Toxicology   14 ( 2 )   279 - 284   1999.5

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    Blue rayon, an adsorbent selective to compounds having three or more fused rings, for detecting benzo(a)pyrene and measuring mutagenicity was used in Lake Baikal (Russia), Asahi River, Sasagase River, and Lake Kojima (Okayama, Japan). One gram of blue rayon was immersed in 1 L of water in a bottle, and manually shaken for 30 min. The blue rayon was recovered and transported to the laboratory where the analyses for benzo(a)pyrene and the mutagenicity assay were performed. The recovered benzo(a)pyrene from the water sample ranged from 0.13 to 0.65 ng/L for take Baikal and from 0.13 to 1.41 ng/L for the rivers and the lake in Okayama. Six samples out of 11 from Lake Baikal showed positive but weak mutagenicity. No mutagenicity was found in the samples from the rivers and the lake in Okayama. The present method allows easy sampling at remote sites because there is no need for transporting voluminous water samples to the place where analysis is performed. (C) 1999 by John Wiley & Sons, Inc.

    DOI： 10.1002/(SICI)1522-7278(199905)14:2<279::AID-TOX9>3.0.CO;2-P

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  • Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital Reviewed

    Toshihito Suzuki, Takehiko Ito, Susan E. Wellman, Ing K. Ho

    European Journal of Pharmacology   354 ( 2-3 )   145 - 151   1998.8

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    We examined changes in benzodiazepine binding sites labeled by [3H]flunitrazepam in five nuclei of the thalamus, the central medial, central lateral, intermediodorsal, ventroposterior, and laterodorsal nuclei, in rats made tolerant to and dependent on pentobarbital. Animals were made tolerant by intracerebroventricular infusion with pentobarbital (300 μg (10 μl)-1 h-1 for six days) through pre-implanted cannulae. Pentobarbital dependence was assessed 24 h after abrupt withdrawal from pentobarbital. Pentobarbital-tolerant rats showed no significant change in [3H]flunitrazepam binding sites (B(max) and K(d)) in any nucleus examined in the thalamus. In the rats made dependent on pentobarbital, significant increases in the B(max) of [3H]flunitrazepam binding without changes in K(d) were noted in central medial and central lateral nuclei. GABAergic (γ-aminobutyric acid) neurons in the ventrobasal nucleus and in nuclei in the midline group are important in seizure regulation and arousal. These findings suggest that alterations of benzodiazepine receptors in certain nuclei of thalami are involved in the physiological changes induced by pentobarbital dependence. There were no changes in the binding parameters for [3H]flunitrazepam in pentobarbital-tolerant rats. Copyright (C) 1998 Elsevier Science B.V.

    DOI： 10.1016/S0014-2999(98)00447-6

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  • Measurement of a time-weighted average concentration of polycyclic aromatic hydrocarbons in seawater: An improved procedure of blue rayon hanging technique for monitoring benzo(a)pyrene Reviewed

    S. Kira, Y. Nogami, T. Ito, H. Hayatsu

    Marine Environmental Research   46 ( 1-5 )   267 - 271   1998.7

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    We have proposed a time-weighted measurement using blue rayon that selectively adsorbs and concentrates polycyclic aromatic hydrocarbons (PAH), e.g. benzo(a)pyrene (BaP). Though the method was demonstrated to be a convenient way to monitor PAH, the amount adsorbed to the blue rayon depends on the intensity of water stream and the level of PAH. The intensity of water stream was measured by 'plaster ball' method, while TWA of PAH in water was measured by a portable sampler using solid phase extraction cartridge. A level of BaP measured by the original blue rayon technique was corrected in this way by the water stream intensity, which correlated well with the TWA of BaP measured by the portable sampler. The improved blue rayon hanging method was applied to several field sites in the Seto Inland Sea of Japan. TWA of BaP ranged from 0.08 to 3.78 ng l-1. These results showed the possibility that the method could be used to evaluate pollution in aquatic environment.

    DOI： 10.1016/S0141-1136(97)00063-9

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  • Measurement of a time-weighted average concentration of benzo(a) pyrene in marine environment(共著) Reviewed

    Journal de Recherche Oceanographique   23 ( 1 )   31 - 35   1998.5

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  • Autoradiographic study on the pharmacological characteristics of [3H]3-OH-PCP binding sites in rat brain Reviewed

    Toshihito Suzuki, Toshifumi Yamamoto, Takafumi Hori, Atsuomi Baba, Hiroyasu Shiraishi, Takehiko Ito, John E. Piletz, Ing Kang Ho

    European Journal of Pharmacology   310 ( 2-3 )   243 - 255   1996.8

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    The pharmacological characteristics and the regional distribution of [3H]3-OH-PCP (1-[1(3-hydroxyphenyl)-cyclohexyl)piperidine) binding were investigated in rat brain by quantitative autoradiography. Kinetic analysis of [3H]3-OH-PCP binding revealed fast and slow components, in the association and dissociation studies. The regional distribution of binding closely corresponded to those of binding sites labeled by [3H]N-[1-(2-thienyl)-cyclohexyl]3,4-piperidine (TCP) and [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine maleate (MK 801). High densities of [3H]3-OH-PCP binding sites were found in the stratum radiatum and oriens of field CA1 in the hippocampus and in the outer layers of cerebral cortices. In contrast, low levels of binding were seen in the brain stem and the granular cell layer of the cerebellum. [3H]3-OH-PCP binding was strongly inhibited by MK 801 and 3-OH-PCP, while the potency of (+)-SKF 10047 in inhibiting [3H]3-OH-PCP binding was less in the cerebral cortex and hippocampus. The antagonists for the glutamate, glycine and polyamine recognition sites at the NMDA/PCP receptor complex displaced [3H]3-OH-PCP binding sites with a potency similar to that of [3H]MK 801. These findings suggest that the [3H]3-OH-PCP binding site is similar or identical to the PCP binding site labeled by [3H]TCP and [3H]MK 801.

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  • An autoradiographic study of [3H]flunitrazepam binding sites in the brain of rat made tolerant to and dependent on pentobarbital Reviewed

    Toshihito Suzuki, Takehiko Ito, Susan E. Wellman, Ing Kang Ho

    European Journal of Pharmacology   295 ( 2-3 )   169 - 179   1996.1

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    The effects of continuous administration of pentobarbital on the benzodiazepine receptor labeled by [3H]flunitrazepam were investigated. Animals were made tolerant to pentobarbital by intracerebroventricular (i.c.v.) infusion with pentobarbital (300 μg/10 μl/h) for 6 days through pre-implanted cannulae connected to osmotic mini-pumps. The dependent rats were assessed 24 h after cessation of pentobarbital infusion. Changes in [3H]flunitrazepam binding were examined in 37 brain regions at a concentration of [3H]flunitrazepam of 1 nM. In subsequent saturation studies, the binding parameters B(max) and K(D) were also investigated in 17 brain regions, most of which showed significant changes in [3H]flunitrazepam binding in experiments using a fixed concentration of radioligand. The pentobarbital-tolerant rats showed a significant increase in B(max) with an increase in K(D) for [3H]flunitrazepam in the ventroposterior nucleus of thalamus. In the dependent rats, a significant increase in B(max) for [3H]flunitrazepam binding, without a change in K(D), was observed in all layers of the frontal cortex, the caudate-putamen, olfactory tubercle, and some nuclei in thalamus, compared to those in the control. Increased [3H]flunitrazepam binding in the molecular layer of the olfactory bulb, the ventral pallidum, and the cerebellum of the pentobarbital dependent rats at a fixed concentration of [3H]flunitrazepam was also observed. There was no significant change in [3H]flunitrazepam binding in the hippocampus and several nuclei of the brain stem. These findings suggest that benzodiazepine receptors are closely involved in the development of tolerance to and dependence on pentobarbital. Further studies on changes in γ-aminobutyric acid (GABA)A receptor subunit mRNA or the effects of pentobarbital on GABA(A) receptor phosphorylation would be necessary for an explanation of the precise mechanisms underlying the development of tolerance to and dependence on pentobarbital.

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  • Measurement of adenosine triphosphate in the brain of mice exposed to normobaric hyperoxygenation

    Ito T, Katayama Y, Edamatsu R, Yufu K, Mori A

    Medical Science Research   23   373 - 374   1995.6

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  • Quantitative Autoradiographic Localization of [H-3] 3-OH-PCP (1-(1(3-Hydroxyphenyl)Cyclohexyl)Piperidine) Binding-Sites In Rat-Brain Reviewed

    T SUZUKI, T YAMAMOTO, T HORI, S ABE, T MOROJI, H SHIRAISHI, T ITO, IK HO

    BRAIN RESEARCH BULLETIN   37 ( 4 )   431 - 435   1995

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    Binding of a novel radioligand, [H-3]3-OH-PCP (1-(1(3-hydroxyphenyl)cyclohexyl)piperidine), to N-methyl-D-aspartate (NMDA) receptor-coupled and -uncoupled PCP sites was investigated in the rat brain. The highest densities of [H-3]3-OH-PCP binding were observed in the hippocampal formation, notably in the stratum radiatum and oriens of CA1 region, and dentate gyrus, There were relatively high levels of binding in the olfactory system, superficial layer of cortices, the amygdala and the thalamus. In contrast, lower levels of binding were found in the globus pallidus, cerebellum, and brain stem, except for the superior colliculus. These findings demonstrate that [H-3]3-OH-PCP binds to discrete regions within the rat brain, Its distribution is consistent with autoradiographic localization of [H-3]TCP and [H-3]MK-801 binding sites in the rat brain, suggesting that [H-3]3-OH-PCP binds to NMDA/PCP ion-channel complexes in preference to sigma sites.

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  • Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital. Reviewed International journal

    T Suzuki, T Ito, S E Wellman, I K Ho

    Life sciences   57 ( 5 )   PL63-9   1995

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    Changes in benzodiazepine binding sites labeled by [3H]flunitrazepan (FNZ) in twenty discrete brain regions of rats made tolerant to and dependent upon pentobarbital were examined. Animals were rendered tolerant by intracerebroventricular (i.c.v.) infusion with pentobarbital (300 micrograms/ 10 microliters/ hr for six days) through pre-implanted cannulae connected to osmotic mini-pumps. The pentobarbital dependence was assessed 24 hr after abrupt withdrawal from pentobarbital. In the tolerant rats, a significant increase in [3H]FNZ binding sites was found in layer IV of frontal cortex and the molecular layer of olfactory bulb. [3H]FNZ binding sites in the pentobarbital dependent rats were significantly increased in layers I-III and V-VI of frontal cortex, caudate-putamen, olfactory tubercle, globus pallidus and ventral pallidum, in addition to those observed in the tolerant group. There was, however, no significant difference in the hippocampus and several regions in the hindbrain in either pentobarbital-treated group. Taken together with characteristics of subtypes of benzodiazepine receptors and changes in GABA-benzodiazepine receptor complexes elucidated in our previous studies, these findings suggest that both types of benzodiazepine receptors are involved in the development of pentobarbital intoxication mediated by GABAA receptors.

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  • Detection of waterborne mutagens and characterization of chemicals in selected Galveston sites after an oil spill Reviewed

    Kira S, Itoh T, Hayatsu H, Taketa K, Zheng Y, Li R, Holliday TL, Giam CS

    Bulletin of Environmental Contamination and Toxicology   53 ( 2 )   285 - 291   1994.8

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  • Changes in Biogenic Amine Neurotransmitters in Rabbit Brain after Radon Inhalation

    YAMAOKA K.

    Neurosciences   20 ( 1 )   17 - 22   1994.1

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  • Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats Reviewed

    Kiyonri Yamaoka, Rei Edamatsu, Takehiko Itoh, Mori Akitane

    Free Radical Biology and Medicine   16 ( 4 )   529 - 534   1994

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    We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity. © 1994.

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  • Changes in Specific Amino-Acid-Residues And Na+,K+-Atpase Activity in Cell-Membranes of Rat Cerebral-Cortex by Low-Dose X-Irradiation Reviewed

    K YAMAOKA, K ISHII, R EDAMATSU, T ITO, A MORI

    PHYSIOLOGICAL CHEMISTRY AND PHYSICS AND MEDICAL NMR   26 ( 4 )   323 - 328   1994

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    This study examines the influence of low dose X-irradiation on the structure and transport function of cell membranes of rat cerebral cortex. We found that unlike high dose irradiation which promotes membrane damage, low dose irradiation stimulates the SH group of membrane proteins and enhances the ability to control the membrane transport mechanism as reflected by an increase in Na+, K+-ATPase activity. The concentration of cysteine (Cys) significantly increased at 25-100 cGy and the concentration of cystine (Cys-Cys) significantly decreased at 25 cGy. It showed no dose dependent changes in tyrosine (Tyr), phenylalanine (Phe) and glycine (Gly). Similarly phospholipid and cholesterol levels were unchanged. Na+, K+-ATPase activities significantly decreased at 100 cGy or higher but significantly increased at doses of 25 and 50 cGy.

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  • Effects of ferric citrate injection on the composition of bile acids in rats Reviewed

    Noda Y, Ogura M, Edamatsu R, Itoh T, Yufu K, Mori A

    Research Communications in Chemical Pathology and Pharmacology   81 ( 3 )   373 - 376   1993.9

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  • Effect of hyperbaric oxygenation on the Na+, K(+)-ATPase and membrane fluidity of cerebrocortical membranes after experimental subarachnoid hemorrhage. Reviewed International journal

    K Yufu, T Itoh, R Edamatsu, A Mori, M Hirakawa

    Neurochemical research   18 ( 9 )   1033 - 9   1993.9

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    It is reported that CNS hemorrhage causes membrane dysfunction and may exacerbate this damage as a result of secondary ischemia or hypoxia. Since hyperbaric oxygenation improves oxygen metabolism, it may reduce this membrane damage. The present study was conducted to reveal whether hyperbaric oxygenation influences membrane alteration after hemorrhage. Thirty minutes after subarachnoid hemorrhage induction, rats were treated with hyperbaric oxygenation 2 ATA for 1 hour. Rats were decapitated 2 hours after subarachnoid hemorrhage induction. Na+, K(+)-ATPase activity measurement and spin-label studies were performed on crude synaptosomal membranes. Subarachnoid hemorrhage decreased Na+, K(+)-ATPase activity. Spin label studies showed that hydrophobic portions of near the membrane surface became more rigid and the mobility of the membrane protein labeled sulfhydryl groups decreased after subarachnoid hemorrhage. Hyperbaric oxygenation significantly ameliorated most of the subarachnoid hemorrhage induced alterations. We conclude that hyperbaric oxygenation may be a beneficial treatment for acute subarachnoid hemorrhage.

    DOI： 10.1007/BF00966765

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  • The effect of hyperbaric oxygen on lipid peroxidation, antioxidant activity and guanidines and amino acids metabolism in rat brain Reviewed

    ITOH Takehiko

    Okayama Igakkai Zasshi (Journal of Okayama Medical Association)   105 ( 3 )   291 - 302   1993

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    Authorship：Lead author   Language：Japanese   Publisher：Okayama Medical Association  

    Lipid peroxidation, free radical contents, antioxidant activity, guanididno compound metabolism and changes in amino acid contents in rat brain were studied to clarify the effect of a clinically relevant dose of hyperbaric oxygen (HBO). Seven-week-old rats were exposed to HBO at 3 atmosphere absolute for 2 hours. An increase in thiobarbituric acid reactive substances and carbon centered radicals was observed after exposure. Superoxide dismutaselike activity also increased. The measurement of guanidino compounds revealed a significant rise in arginine and guanidinoacetic acid (GAA) levels. Since arginase activity decreased while there was no significant alteration in arginine: glycine-amidinotransferase activity, these changes in enzyme activities seem to cause the increase of arginine and GAA levels. In relation to guanidino compound metabolism, the amino acid contents were determined. An increase in glutamine and taurine levels were observed and these seemed to favor the defense mechanism. These data suggested that ongoing lipid peroxidation in the brain was caused by HBO, and that the defense mechanism against the oxidative stress was activated in response.

    DOI： 10.4044/joma1947.105.3-4_291

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  • 2-Guanidinoethanol increased dopamine release and 3,4-dihydroxyphenylacetic acid content, but not homovanillic acid content in the rat brain: Electroneurochemical and enzymological studies Reviewed

    Isao Yokoi, Hideaki Kabuto, Katsuhisa Hukuyama, Yutaka Nishijima, Takehiko Itoh, Katsumi Yufu, Kenji Akiyama, Akitane Mori

    Neurochemical Research   17 ( 7 )   735 - 740   1992.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Kluwer Academic Publishers-Plenum Publishers  

    The effects of 2-guanidinoethanol (GEt) on the release of monoamines and on the activity of their degrading enzymes were studied in order to investigate why 3,4-dihydroxyphenylacetic acid (DOPAC) increased to a much greater extent than homovanillic acid (HVA) after GEt injection into rat brain. In differential pulse voltammograms recorded using an electrochemically treated carbon fiber electrode, two distinct oxidation peaks, one at 130mV (DOPAC peak) and the other at 300 mV (5-hydroxyindoleacetic acid (5-HIAA) peak), were observed. In the hippocampus, the DOPAC peak increased markedly compared to the peak height recorded prior to the intracerebroventricular injection of GEt (6μmol). Although the DOPAC peak height increased to 350% 4 hours after GEt injection, the 5-HIAA peak showed no change. In the striatum, the DOPAC peak increased to 150% 3 hours after GEt injection. Serial changes in the extracellular levels of DOPAC, HVA, and 5-HIAA were monitored in the striatum after GEt injection, using an in vivo brain micro-dialysis technique. Although the DOPAC levels strated to increase 80 minutes after GEt injection, HVA and 5-HIAA levels showed no change. On the other hand, monoamineoxidase, which metabolizes dopamine to DOPAC, was not activated and catechol-0-methyltransferase, which metabolizes DOPAC to HVA, were not inhibited by 5 mM of GEt in vitro. These data suggested that GEt increased the release of dopamine, but not of serotonin, and that GEt might restrict the DOPAC transport system. © 1992 Plenum Publishing Corporation.

    DOI： 10.1007/BF00968014

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  • Free Radical in Brain of Spontaneously Epileptic Rat(SER). Reviewed

    MORI Akitane, KATAYAMA Yasuto, EDAMATSU Rei, ITOH Takehiko, YUFU Katsumi, NODA Yasuko, TAKAYAMA Misako

    Proceedings of The Japanese Society of Animal Models for Human Diseases   8   27 - 33   1992

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Association for Laboratory Animal Science  

    The spontaneously epileptic rat (SER; &lt;I&gt;zi/zi&lt;/I&gt;, &lt;I&gt;tm/tm&lt;/I&gt;) is the double mutant obtained by mating the tremor rat (TRM; &lt;I&gt;tm/tm&lt;/I&gt;) with the zitter rat (ZI; &lt;I&gt;zi/zi&lt;/I&gt;), exhibits tonic convulsions and absencelike seizures without external stimulation, and has marked vacuolation and hypomyelination in the brain. Vacuole formation is seen widely in the brain of TRM rat as same as SER. As free radical and its related materials may possibly participate to form vacuole in the brain of SER and TRM rats, free radicals (&amp;sdot;C, &amp;sdot;OH, &amp;sdot;H), TBARS level, SOD activity and content of fatty acids were investigated.&lt;BR&gt;During maturation, free radicals and Cu, Zn-SOD activities in the brain of SER did not change, but TBARS levels in cerebellum and pons-medulla oblongata increased. On the other hand, in pons-medulla oblongata of TRM rats, Cu, Zn-SOD activity and &amp;sdot;OH radical increased during maturation. In the same region of the 24-week-old TRM rats, TBARS level increased and the content of arachidonic acid (C&lt;SUB&gt;22: 4&lt;/SUB&gt;) decreased significantly compared with those in WTC rats. These results suggest that vacuole formation may be caused by lipid peroxidation of membrane.

    DOI： 10.1538/expanim1992.8.27

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  • Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain Reviewed

    Yokoi I, Itoh T, Yufu K, Akiyama K, Satoh M, Murakami S, Kabuto H, Mori A

    Neurochemical Research   16 ( 10 )   1155 - 1159   1991.10

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  • 包括的健康教育の指導者養成の理論と実践

    伊藤, 武彦, 上村, 弘子（ Role： Joint editor ,  共編著，分担執筆）

    大学教育出版  2024.3  （ ISBN:9784866922973 ）

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    Total pages：vii , 175p   Language：Japanese

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  • グランドデザインから考える小児保健ガイドブック

    秋山, 千枝子, 五十嵐, 隆, 岡, 明, 平岩, 幹男（ Role： Contributor ,  各論F ４． 健康教育）

    診断と治療社  2021.4  （ ISBN:9784787824738 ）

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  • 健康教育の理論と実践 : わが国と外国の事例をもとに

    伊藤, 武彦, 松村, 京子, 鬼頭, 英明（ Role： Joint editor ,  共編者および分担執筆：第1章1節「包括的健康教育プログラムの構築を目指して―序論―」，第6章「私たちの包括的健康教育のこれから―まとめに代えて―」）

    日本学校保健会,丸善出版 (発売)  2018.3  （ ISBN:9784903076188 ）

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  • 公衆衛生領域における連携と協働：理念から実現に向けて

    伊藤 武彦（ Role： Contributor ,  学校保健と地域社会―連携と協働を求めて―）

    日本公衆衛生協会  2015.10 

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  • 今日の小児治療指針 第15版

    （ Role： Contributor ,  学校環境衛生とその対策）

    医学書院  2012  （ ISBN:9784260012317 ）

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  • 学校組織マネジメントとスクールリーダー

    学文社  2007 

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  • Effect of hyperbaric oxygen exposure on brain arginase and arginine : glycine amidinotransferase activity(共著)

    "Guanidino Compounds in Biology and Medicine II"John Libbey, London 

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  • Effect of hyperbaric hyperoxygenation on guanidino compounds in rat brain. in ed: DeDyne PP, Marescau B, et. al. “Guanidino compounds in biology and medicine” pp. 403-408

    John Libbey, London  （ ISBN:086196330X ）

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  • Effect of hyperbaric oxygen exposure on brain arginase and arginine : glycine amidinotransferase activity(共著)

    "Guanidino Compounds in Biology and Medicine II"John Libbey, London 

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  • Effect of hyperbaric oxygen exposure on brain arginase and arginine : glycine amidinotransferase activity in "Guanidino Compounds in Biology and Medicine II" pp. 87-91

    John Libbey, London  （ ISBN:0861965434 ）

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  • The effect of hyperoxygenation on the membrane fluidity of mouse synaptosome in ed. Yagi K, Kondo M, et al., “Oxygen Radicals”pp. 397-400

    Elsevier Science,Amsterdam  （ ISBN:0444894853 ）

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  • 生活・健康系教育連合講座 ( I 教育実践の歩み，今後の展望 )

    伊藤 武彦, 菊地 章

    教育実践学論集   0   S35 - S37   2017

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    Language：Japanese   Publisher：兵庫教育大学大学院連合学校教育学研究科  

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  • 小地域分析を用いた通学区域内のリスク分析の基礎的研究

    伊藤 武彦

    科学研究費補助金報告書基盤C   2010

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  • A study of intestinal parasito eggs in Japanese school children

    KUROSAWA Carmen, ITO Takehiko, WANG Bingling, TAKIGAWA Tomoko, OGINO Keiki

    日本衞生學雜誌   62 ( 2 )   654 - 654   2007.3

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  • Involvement of oxidative stress in pyrogallol-induced mutagenicity and cytotoxicity

    TAKEMURA Yoko, WANG Da Hong, SAURIASARI Rani, HORITA Masako, MASUOKA Noriyoshi, ITO Takehiko, OGINO Keiki

    日本衞生學雜誌   62 ( 2 )   634 - 634   2007.3

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  • 過疎地域の診療科目別医療施設分布と高齢者の受診行動に関する研究

    関 明彦, 伊藤武彦, 瀧川智子

    平成17年度〜平成18年度科学研究費補助金（基盤研究(C)）研究成果報告書   2007

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  • 有機溶剤曝露が幼若動物の脳内GABA神経系の発達に及ぼす影響についての実験的研究

    伊藤武彦

    平成15－16年度科学研究費補助金（基盤研究(C)（2））研究成果報告書   2006

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  • マネジメントのための地域診断－地域環境をとらえる指標－

    伊藤武彦

    平成16〜18年度兵庫教育大学連合研究科共同研究プロジェクトＤ 第２年次研究成果報告書 （兵庫教育大学連合学校教育学研究科）   2006

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  • 国内学会ニュース 第52回日本職業・災害医学会学術大会に参加して

    伊藤 武彦

    産業医学ジャーナル   28 ( 2 )   32 - 36   2005.3

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    Language：Japanese   Publisher：産業医学振興財団  

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  • P2072 小動物用気体吸入実験装置の試作

    伊藤 武彦, 吉良 尚平

    産業衛生学雑誌   47 ( 0 )   773 - 773   2005

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    Language：Japanese   Publisher：公益社団法人 日本産業衛生学会  

    DOI： 10.1539/sangyoeisei.KJ00003804404

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  • 第52回日本職業・災害医学会学術大会に参加して

    伊藤武彦

    産業医学ジャーナル   2005

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  • 学校をとりまく地域をどう分析するか

    伊藤武彦

    2004〜2006年度兵庫教育大学連合研究科共同研究プロジェクトＤ 第１年次研究成果報告書   2005

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  • 過疎地域の産科医療が抱える問題に関する研究

    関明彦, 伊藤武彦, 吉良尚平

    2003－2004年度科学研究費補助金（基盤研究C（2））研究成果報告書   2005

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  • 岡山大学における養護教諭養成カリキュラムの開発 (多様な教育実践の探究)

    高橋 香代, 伊藤 武彦, 三村 由香里

    教科教育学研究   21   145 - 158   2003

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    Language：Japanese   Publisher：日本教育大学協会第二常置委員会  

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  • 岡山大学における養護教諭養成カリキュラムの開発

    高橋香代, 伊藤武彦, 三村由香里, 河内信子, 小出彌生, 門田新一郎

    教科教育研究   2003

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  • 11.m-キシレン曝露による脳内m-キシレン濃度の経時的変化(第29回有機溶剤中毒研究会)

    伊藤 武彦, 吉留 敬, 堀家 徳士, 瀧川 智子, 中山 祥嗣, 関 明彦, 吉良 尚平

    産業衛生学雑誌   44 ( 1 )   29 - 29   2002

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    Language：Japanese   Publisher：公益社団法人 日本産業衛生学会  

    DOI： 10.1539/sangyoeisei.KJ00002552646

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  • 18.ホルムアルデヒドの高感度分析法(第45回中国四国合同産業衛生学会)

    堀家 徳士, 瀧川 智子, 伊藤 武彦, 吉良 尚平

    産業衛生学雑誌   44 ( 2 )   86 - 86   2002

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    Language：Japanese   Publisher：公益社団法人 日本産業衛生学会  

    DOI： 10.1539/sangyoeisei.KJ00002552764

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  • A simplified procedure for the analysis of aldehydes by hplc in biological samples

    HORIKE T, TAKIGAWA T, ITO T, KIRA S

    SANGYO EISEIGAKU ZASSHI   44 ( 0 )   639 - 639   2002

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    Language：Japanese   Publisher：Japan Society for Occupational Health  

    DOI： 10.1539/sangyoeisei.KJ00003948042

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  • Time course of m-xylene and its metabolite concentration in the rat brain under m-xylene exposure

    ITO T

    SANGYO EISEIGAKU ZASSHI   44 ( 0 )   800 - 800   2002

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    Language：Japanese   Publisher：Japan Society for Occupational Health  

    DOI： 10.1539/sangyoeisei.KJ00003948202

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  • 有機溶剤曝露後の脳内有機溶剤濃度とGABAA受容体の変化に関する研究

    伊藤武彦

    平成12－13年度科学研究費補助金（基盤研究C（2））研究成果報告書   2002

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  • Distribution of Inhaled m-Xylene in Rat Brain and its Effect on GABA_A Receptor Binding

    ITO Takehiko, YOSHITOME Kei, HORIKE Tokushi, KIRA Shohei

    SANGYO EISEIGAKU ZASSHI   44 ( 2 )   2002

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    Language：Japanese   Publisher：Japan Society for Occupational Health  

    DOI： 10.1539/joh.44.69

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  • Analysis of Aldehydes in Biological Samples

    HORIKE T, ITO T, USAMI M, Wang, DH, YAMAMOTO H, KIRA S

    産業衛生学雑誌 = Journal of occupational health   43   686 - 686   2001.3

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  • Effect of m-xylene exposure on GABA A receptors

    ITO T

    産業衛生学雑誌 = Journal of occupational health   43   556 - 556   2001.3

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  • 4.m-キシレン曝露の脳内GABA受容体に及ぼす影響(第28回有機溶剤中毒研究会)

    伊藤 武彦, 中山 祥嗣, 瀧川 智子, 吉良 尚平

    産業衛生学雑誌   43 ( 6 )   227 - 227   2001

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    DOI： 10.1539/sangyoeisei.KJ00002552570

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  • Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats

    Toshihito Suzuki, Toshihito Suzuki, Shuzo Abe, Mika Yamaguchi, Atsuomi Baba, Takafumi Hori, Hiroyasu Shiraishi, Takehiko Ito

    Synapse   38   167 - 176   2000.10

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    The acute effects of systemic administration of the anti-obesity agent sibutramine on extracellular dopamine (DA) in the nucleus accumbens of freely moving rats were studied using in vivo microdialysis and compared with the actions of phentermine and d-amphetamine at doses 1x and 3x their respective 2 h ED50 values to reduce food intake in rats. At the lower dose, sibutramine did not elevate extracellular DA concentrations; however, at the higher dose (6.0 mg kg-1, i.p.) it caused a modest and prolonged increase in extraneuronal DA. A maximal rise was observed at 60 min post-sibutramine treatment (+231% compared to controls) with DA levels remaining elevated for up to 160 min post treatment. In contrast, phentermine and d-amphetamine significantly enhanced DA efflux at both the lower and higher doses. These elevations of DA levels were significantly greater than that seen with the corresponding dose of sibutramine over 0-80 min post treatment. Maximal rises in DA levels resulting from the higher dose of each drug were +733% (phentermine, 3.9 mg kg-1, i.p.) and +603% (d-amphetamine, 1.5 mg kg-1, i.p.) compared to controls 40 min post treatment. The highest doses of phentermine and d-amphetamine increased rat locomotor activity up to 100 min and 160 min post treatment, respectively, whereas the equivalent sibutramine dose had no effect. These findings therefore suggest that dopaminergic reward mechanisms are not involved in the reduction of food intake by sibutramine. Furthermore, they are consistent with the view that sibutramine lacks abuse potential. (C) 2000 Wiley-Liss, Inc.

    DOI： 10.1002/1098-2396(200011)38:2<167::AID-SYN8>3.0.CO;2-W

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  • Alteration in GABA receptors following xylene exposure to rats and distribution of xylene in their body

    ITO T

    産業衛生学雑誌 = Journal of occupational health   42   343 - 343   2000.3

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  • Measurement of a time-weighted average level (TWA) of benzo (a) pyrene in sea water by blue rayon hanging

    NAKAYAMA Shoji, TAKIGAWA Tomoko, NOGAMI Yusaku, ITO Takehiko, HAYATSU Hikoya, KIRA Shohei

    日本環境変異原学会大会プログラム・要旨集   ( 29 )   87 - 87   2000

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  • 4. 有機溶剤乱用のモデル動物作成(第45回労働衛生史研究会)

    伊藤 武彦, 関 明彦, 秀衡 隆志, 中山 祥嗣, 堀家 徳士, 王 達紘, 吉良 尚平

    産業衛生学雑誌   42 ( 1 )   31 - 31   2000

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    DOI： 10.1539/sangyoeisei.KJ00002552198

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  • Effects of acute and chronic phencyclidine administration on the expression of subunit mRNA for NMDA and GABA_A receptors in rat brain

    ABE Shuzo, SUZUKI Toshihito, BABA Atsuomi, KURITA Hirofumi, SHIRAISHI Hiroyasu, ITO Takehiko

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   19 ( 6 )   374 - 374   1999.12

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  • Effect of repeated administration of cocaine on a level of NMDA receptor subunit mRNA in rat brain

    SUZUKI Toshihito, ABE Shuzo, YAMAGUCHI Mika, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   19 ( 6 )   383 - 383   1999.12

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  • Time-dependent changes in a level of GABA_A receptor subunit mRNA following cocaine administration

    YAMAGUCHI Mika, SUZUKI Toshihito, ABE Shuzo, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   19 ( 6 )   424 - 424   1999.12

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  • 各種統計データを生かした小地区分析事業－公衆衛生学的地区調査－

    中林圭一, 吉田秋子, 吉良尚平, 今井香織, 伊藤武彦, 関 明彦

    平成10年度産学連携研究（岡山県保健福祉部保健福祉課；小地区分析検討事業）「各種統計データを生かした小地区分析事業－公衆衛生学的地区調査－」研究報告書   1999

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  • 青少年の薬物乱用防止に関する政策と教育 －日米比較研究－

    伊藤武彦

    1997年度（後期）松下国際財団研究助成報告書   1999

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  • Effects of cocaine on the binding sites and subunits mRNA of GABA_A-benzodiazepine (BZD) receptor complexes in rat brain

    YAMAGUCHI Mika, SUZUKI Toshihito, ABE Shuzo, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko, OKADO Nobuo

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   18 ( 6 )   387 - 387   1998.12

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  • Differential expression of GABA_A/benzodiazepine receptor subunit mRNA and ligand binding sites in rat brain following phencyclidine administration : An autoradiographic analysis

    ABE Shuzo, SUZUKI Toshihito, BABA Atsuomi, KURITA Hirofumi, SHIRAISHI Hiroyasu, ITO Takehiko, OKADO Nobuo

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   18 ( 6 )   311 - 311   1998.12

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  • Changes in Specific Amino Acid Residues and Na^+,K^+ -ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-Irradiation : Changes in Specific Amino Acid Residues and Na^+,K^+ -ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-Irradiation

    YAMAOKA Kiyonori, EDAMATSU Rei, ITOH Takehiko, MORI Akitane

    Journal of radiation research   35 ( 4 )   257 - 257   1994

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    Language：English   Publisher：the Japan Radiation Research Society  

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=233943

  • 9.Tremor rat脳におけるNa, K-ATPase活性ならびに膜流動性の変化について

    伊藤 武彦, 片山 泰人, 枝松 礼, 油布 克巳, 森 昭胤

    日本疾患モデル学会記録   9 ( 0 )   49 - 49   1993

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    Language：Japanese   Publisher：公益社団法人 日本実験動物学会  

    DOI： 10.1538/expanim1992.9.49

    CiNii Article

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Presentations

  • 卒業時健診と学校医が参加する教育的活動の可能性について-小学校と特別支援学校での実践から-

    日本学校保健学会第64回学術大会  2017 

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  • 学校保健と地域の連携 ～小山町の実践に学ぶ連携・協働の重要性～

    第23回岡山県保健福祉学会  2017 

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  • 寒冷期の小学校普通教室の気温とその環境についての考察

    第90回日本産業衛生学会  2017 

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  • 小学校の校舎の構造と教室内の気温について

    日本産業衛生学会平成28年度第1回温熱環境研究会  2016 

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  • 小学校普通教室の気温に及ぼす校舎の構造等の影響

    第89回日本産業衛生学会  2016 

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  • O市の小学校の屋内外の暑熱環境の実態

    第60回日本学校保健学会  2013 

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  • 教員の作業環境としての小学校の教室における暑熱環境の調査

    第86回日本産業衛生学会  2013 

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  • 岡山市の救急搬送例にみる運動時の熱中症について

    第37回岡山スポーツ医科学研究会  2013 

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  • 高齢者の室内熱中症予防のための居住環境調査

    第72回日本公衆衛生学会総会  2013 

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  • 小学校普通教室の暑熱環境に関する簡便な熱収支モデルの構築

    第60回日本学校保健学会  2013 

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  • 高齢者の熱中症予防のための居住環境実態調査－屋内外の暑熱負荷に着目して－

    第19回岡山県保健福祉学会  2013 

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  • 学校の温熱環境と産業保健・学校保健の課題について

    日本産業衛生学会平成25年度第1回温熱環境研究会  2013 

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  • Ｏ市における小学校の普通教室における暑熱環境とその対策について

    第85回日本産業衛生学会  2012 

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  • Ｏ市における熱中症救急搬送例の小学校区別分布について

    第71回日本公衆衛生学会総会  2012 

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  • 継続的自動測定を行ったO市の小学校の普通教室における暑熱環境の分析

    第59回日本学校保健学会  2012 

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  • 学校区などの小地域を単位とした熱中症予防対策の可能性について ～岡山市内の小学校・中学校の普通教室等の気温調査を基盤として～

    第18回岡山県保健福祉学会  2012 

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  • 岡山市内の湿球黒球温度（WBGT）の同時多点計測

    第34回岡山スポーツ医科学研究会  2010 

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  • O市内の同時多点測定による小地域の湿球黒球温度（WBGT）の分布について

    第69回日本公衆衛生学会総会  2010 

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  • Ｏ市における過去３年間の暑熱期の熱中症救急搬送例にみる屋外作業時の暑熱環境

    第83回日本産業衛生学会総会  2010 

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  • Ｏ市における過去３年間の暑熱期の熱中症救急搬送例と湿球黒球温度の関係について

    第68回日本公衆衛生学会総会  2009 

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  • 各種課外活動の現場における湿球黒球温度（WBGT）の暑熱期を通した測定

    第56 回日本学校保健学会  2009 

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  • 中学校における歯科保健統計にみる地域性の分析

    第56 回日本学校保健学会  2009 

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  • 推定湿球黒球温度を使った熱中症の発生状況の検討－岡山市における救急搬送例（2006〜2008年）のデータを用いて－

    第３３回岡山スポーツ医科学研究会  2009 

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  • 種々の学校現場での湿球黒球温度（WBGT）の測定

    平成21年度第2回日本産業衛生学会温熱環境研究会  2009 

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  • 本学大学生の課外活動中の暑熱環境に関する調査（2007年度）

    第32回岡山スポーツ医科学研究会  2008 

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  • 二次医療圏別の分娩取扱い施設数と医療圏外への分娩流出率、および、その年次推移

    第67回日本公衆衛生学会  2008 

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  • 熱中症を科学する

    日本養護教諭教育学会第16回学術集会  2008 

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  • 大学生における血管老化状態と食生活との関連

    第67回日本公衆衛生学会  2008 

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  • 昭和四十年代の中学校におけるう歯とその治療についての地域分析

    第５５回日本学校保健学会  2008 

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  • 小地域分析の学校安全への活用

    第５５回日本学校保健学会  2008 

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  • 学校周辺の夜間路面照度の多点式測定法の開発

    第54回日本学校保健学会  2007 

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  • 大学生の課外活動中の暑熱環境と自覚症状等に関する調査（速報）

    第31回岡山スポーツ医科学研究会  2007 

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  • 眼科・耳鼻咽喉科医療施設分布の地域格差

    第66回日本公衆衛生学会  2007 

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  • 日本の児童・生徒における寄生虫卵保有率に関する研究

    第77回日本衛生学会総会  2007 

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  • 染色剤に含まれるピロガロールの細胞毒性と活性酸素の関与

    第77回日本衛生学会総会  2007 

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  • CATassayを用いた最終処分場の浸出水，放流水における酸化ストレス調査

    第76回日本衛生学会  2006 

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  • 国勢調査小地域統計の学校安全への活用の提案

    第53回日本学校保健学会  2006 

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  • Changes in GABAA receptor binding in the brain of rats exposed to m-xylene

    Neuroscience 2006 (The 36th Annual meeting of Society for Neuroscience)  2006 

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  • 日本の児童における寄生虫卵保有率の変化に影響した要因についての研究

    第76回日本衛生学会  2006 

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  • Decreasing Number of Maternity Hospitals in Japan; Current Conditions and Problems

    FIGO 2006(International Federation of Gynecology & Obstetrics; the XVIII FIGO World Congress)  2006 

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  • 中国四国地方の産婦人科施設における分娩取扱い中止の状況とその理由

    第65回日本公衆衛生学会総会  2006 

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  • カタラーゼ変異遺伝子を導入した大腸菌における化学物質による細胞毒性と食品 由来酸化物質の抑制作用

    第16回中国四国生体ラジカル研究会  2005 

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  • 小動物用気体吸入実験装置の試作

    第78回日本産業衛生学会  2005 

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  • 阿新・真庭保健所管内の妊産婦の産科施設への受診動向 〜通院時間とそれに伴う負担感について〜

    第11回岡山県保健福祉学会  2005 

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  • カタラーゼ遺伝子を指標とした有害化学物質に対するリスク評価法の開発（第3報）

    第75回日本衛生学会  2005 

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  • iタウンページを利用した保健福祉施設分布分析

    第75回日本衛生学会  2005 

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  • 中国四国地方の分娩取扱施設の状況

    第59回日本産婦人科学会中国四国合同地方部会  2005 

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  • 遠距離の通院をしている妊婦に関する問題〜産科医への調査から〜

    第64回日本公衆衛生学会総会  2005 

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  • 学校を取り巻く地域環境の変遷と学校経営

    シンポジウム「学校経営におけるマネジメント能力をいかに育てるか－学校組織マネジメントの独自性と個別性－」  2005 

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  • 通学区域表示システムの作成とそれを用いた分析の試み

    第64回日本公衆衛生学会総会  2005 

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  • エクセル上の地図描画プログラムの作成（続報）

    第６３回日本公衆衛生学会  2004 

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  • 学校をとりまく地域をどう分析するか

    ワークショップ「スクールリーダー育成のための教育プログラムの開発」  2004 

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  • カタラーゼ遺伝子を指標とした有害化学物質に対するリスク評価法の開発（第2報）

    第74回日本衛生学会  2004 

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  • 過疎地域における妊産婦の産科施設への受診動向とその問題点

    第６３回日本公衆衛生学会  2004 

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  • カタラーゼ遺伝子の変異を指標とした有害化学物質に対するリスク評価法の開発（第一報）

    第73回日本衛生学会  2003 

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  • 小・中学校における長期欠席者の都道府県別時系列変化についての一考察

    第62回日本公衆衛生学会  2003 

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  • 地理情報システムを用いた保健統計教育の試み

    第73回日本衛生学会  2003 

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  • 統計情報の地図表示システム

    岡山大学リエゾン・オフィスフェア  2002 

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  • 保健医療情報の地図表示システムの構築

    第61回日本公衆衛生学会  2002 

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  • m-キシレン曝露による脳内m-キシレン濃度とその代謝産物の経時的変化

    第75回日本産業衛生学会  2002 

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  • 基本健康診査における生活習慣病一次予防の可能性 臨床医に対するアンケート調査から

    第72回日本衛生学会  2002 

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  • エクセル上の電子地図描画プログラムの作成

    第61回日本公衆衛生学会  2002 

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  • m-キシレン曝露による脳内m-キシレン濃度の経時的変化

    第29回有機溶剤中毒研究会  2001 

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  • A simplified procedure for the analysis of aldehydes by HPLC in aqueous and biological samples

    The 10th International Symposium on Toxicity Assessment  2001 

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  • Monitoring benzo(a)pyrene in sea water of the Seto Inland Sea, Japan,

    The 10th International Symposium on Toxicity Assessment  2001 

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  • 岡山県下の産科施設分布の現状とその課題

    第54回日本産婦人科学会中国四国合同地方部会総会ならびに学術講演会  2001 

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  • 国勢調査統計データの表示システムの構築

    第7回岡山県保健福祉学会  2001 

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  • 生体試料中のアルデヒド類測定法の検討

    第74回日本産業衛生学会  2001 

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  • m-キシレン曝露の脳内GABA受容体に及ぼす影響

    第74回日本産業衛生学会  2001 

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  • Revision of the training program for nurse teachers (Yogo-kyoyu) in Okayama University, Japan.

    Biennial International School Nursing Conference  2001 

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  • 国勢調査地域メッシュの表示・分析システムの構築

    第59回日本公衆衛生学会  2000 

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  • 国勢調査データの町丁字別分析システムの構築

    第59回日本公衆衛生学会  2000 

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  • キシレンの生体内分布と脳内GABA受容体の変化

    第73回日本産業衛生学会  2000 

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  • Effect of m-xylene on [35S]t-butyl- bicyclophosphorothionate binding in the rat brain

    The 30th annual Meeting of the Society for Neuroscience  2000 

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  • m-キシレン曝露の脳内GABA受容体に及ぼす影響

    第28回有機溶剤中毒研究会  2000 

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  • 改良型ブルーレーヨン（BR）懸垂法による海水中Benzo(a)pyreneの時間加重平均値（TWA）の測定

    日本環境変異原学会第29回大会  2000 

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  • Measurement of benzo(A)Pyrene in sea water and in mussels in the Seto Inland Sea, Japan

    The 9th International Symposium on Toxicity Assessment  1999 

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  • 有機溶剤乱用のモデル動物作成

    第27回有機溶剤中毒研究会  1999 

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  • Benzo(a)pyrene adsorbed to suspended solid in fresh water

    The 9th International Symposium on Toxicity Assessment  1999 

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  • 地理情報システムによる国勢調査データを用いた小地区分析(II)システム活用の実際

    第58回日本公衆衛生学会  1999 

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  • 地理情報システムによる国勢調査データを用いた小地区分析(I)システムの構築

    第58回日本公衆衛生学会  1999 

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Works

  • 地理情報システムによる国勢調査データを用いた小地区分析

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  • 青少年の薬物乱用防止に関する政策と教育-日米比較研究-

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Awards

  • 第86回日本産業衛生学会優秀ポスター賞

    2013.5   教員の作業環境としての小学校の教室における暑熱環境の調査

    伊藤武彦

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    Country：Japan

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  • 岡山県保健福祉学会 保健福祉部長賞

    2013.1   岡山県保健福祉学会   高齢者の熱中症予防のための居住環境実態調査－屋内外の暑熱負荷に着目して－

    伊藤武彦, 鈴木久雄, 野口福子, 中瀬克己

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    Country：Japan

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  • 日本産業衛生学会GP奨励賞

    2012.5   日本産業衛生学会   ダンス練習場の暑熱環境改善の一事例

    伊藤武彦, 鈴木久雄, 加賀 勝

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  • 岡山県保健福祉学会 審査委員長賞

    2012.1   岡山県保健福祉学会   学校区などの小地域を単位とした熱中症予防の可能性について ～岡山市内の小学校・中学校の普通教室等の気温調査を基盤として

    伊藤武彦, 中山いづみ, 鈴木久雄

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  • 第５８回日本学校保健学会優秀発表賞

    2011.11   日本学校保健学会   デジタル簡易無線を使った学校間通信の可能性について

    伊藤武彦, 中山いづみ, 坂根弘子

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  • 岡山保健福祉学会会長賞（共同受賞）

    2001  

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  • 米国毒性学会中南部会最優秀論文賞(Society of Toxicology,South Central Chapter,Best Paper Award)

    1995  

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Research Projects

  • Cultivation of social capital in the cooperation and collaboration of school health and community health activities

    Grant number：16K01761  2016.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ito Takehiko

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    Grant amount：\3120000 （ Direct expense: \2400000 、 Indirect expense：\720000 ）

    Cooperation and collaboration in school health and community health activities that utilizes local social capital might itself cultivate social capital within the school district. We have conducted observation/participation study on good practices in school health in a local vicinity to determine the hypothesis were true. In such occasions, cooperation and collaboration in school health and community health activities seemed to enhance people in the community to know each other, share and solve the health issue that they saw in common. Such activities seemed to result in further enhancement of social capital.

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  • Basic study on risk analysis within a school district using small area analysis

    Grant number：19500578  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ITO Takehiko

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    Grant amount：\2340000 （ Direct expense: \1800000 、 Indirect expense：\540000 ）

    本研究では,児童生徒の登下校中の安全に大きく影響する通学区域内の安全について,小地域分析の手法を用いて分析・考察したもので,地域社会のリスクを,国勢調査の小地域統計データなどを組み合わせて分析し,背景となるリスクまたはリスク因子を電子地図の上で可視化することによって,通学区域内のリスクアセスメント・リスクコミュニケーションのためのツールを開発し,「根拠に基づく学校安全」の基盤的研究を行った。

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  • DEVELOPMENT AND ITS PRACTICAL USE OF SCREENING METHODS ON HAZARD IDENTIFICATION USING CATALASE MUTANT GENE AS A PREDICTIVE INDEX

    Grant number：17390173  2005 - 2007

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    WANG Da-hong, TSUTSUI Ken, SANO Kuniaki, MASUOKA Noriyoshi, ITO Takehiko, OGINO Keiki

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    Grant amount：\7520000 （ Direct expense: \7100000 、 Indirect expense：\420000 ）

    This research aimed at developing a screening method for hazard identification using catalase mutant E coli strains constructed by encoding the catalase cDNA from catalase mutant mice (Cs^b) and its corresponding wild type (Cs^a) into catalase-deficient K coli UM255. To assess the cytotoxicity of the chemicals, we employed a CAT assay (a zone of inhibition test of bacterial growth and colony-forming efficiency test using catalase mutant E coli strains). Lawsone exposure inhibited the growth of both Cs^a and Cs^b strains in a dose-dependent manner, in which Cs^b was more susceptible than Cs^a, showing the larger zone of growth inhibition surrounding the paper disc. Natural henna leaves did not show toxic effects, whereas two out of four samples of market henna products were shown toxicity effects. Catalase abolished zone of inhibition of henna products, and low concentration of exogenous MnSOD and Cu/ZnSOD eliminated the toxicity. We also exposed dithiothreitol (DTT) to catalase mutant E coli strains. The results show that DTT was also toxic to the catalase mutant K colis in dose dependent manner and significantly different between Cs^a and Cs^b. Catalase, CuZnSOD, and MnSOD also showed protective ability on tester strains. Treatment with waste disposal extracted by methanol and sterilized water showed a negative relation between the exposure dose and survival of these strains. The results support the usefulness of these newly established strains for hazard identification of oxidative chemicals in a risk assessment process.

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  • The geographical distribution of medical care facilities of several specialties in under populated areas and how elderly people's use of these facilities

    Grant number：17590542  2005 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    SEKI Akihiko, ITO Takehiko, TAKIGAWA Tomoko

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    Grant amount：\2200000 （ Direct expense: \2200000 ）

    1. The geographical distribution of medical facilities that provide ophthalmologic or otolaryngologic care
    The geographical distribution of medical facilities that provide ophthalmologic or otolaryngologic care was visualized using GIS. These facilities were unevenly distributed generally dense in urban areas.
    2. Medical care provided in the medical facilities under research
    The care provided in the hospitals in rural areas was somewhat restricted, e.g. outpatient clinic not open daily, no surgical operation provided. The restrictions seemed to deteriorate the regional difference in the care provided.
    3. Visits of elderly to the medical facilities in rural areas and difficulties they feel
    Percentage of people who visited the facilities by car was larger in rural areas than urban areas. Those who were not able to drive by themselves had no choice but to ask somebody to take them to the medical facilities by car, or to use public transportation system, which is not necessarily convenient in rural areas. The data suggested that the difficulties in transportation added restriction to frequent visit to the medical facilities.
    4. The problems pointed out by ophthalmologists or otolaryngologists
    Many ophthalmologists or otolaryngologists felt that patients must travel a long distance before they could get to their medical facilities, which might restrict the patients' visit to them. Some of these physicians had pointed out that the situation might lead to delayed diagnosis or prolonged therapy.
    We have verified that maintenance of medical facilities in rural areas was difficult in terms of economy. Together with less availability of employed doctors in rural areas, ophthalmologic or otolaryngologic care has been suspended.
    5. Conclusion
    The present study revealed that sociomedical issues specific to under populated area were apparent in the specialties of ophthalmology and otolaryngology. Considering the underlying cause of the problem, we supposed that similar phenomena prevailed in other specialized medical care.

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  • Problems of Maternity Medicine in Depopulated Areas

    Grant number：15590547  2003 - 2004

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    SEKI Akihiko, ITO Takehiko

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    Grant amount：\1600000 （ Direct expense: \1600000 ）

    1.Distribution of maternity hospitals in Japan
    Distribution of maternity hospitals was visualized as a map. In depopulated areas, many regions with no maternity hospital were detected form the map.
    2.Current conditions of pregnant women living in depopulated area
    Pregnant women in depopulated areas took remarkably longer time and felt remarkably severe burden for attending maternity hospitals than pregnant women in urban areas. Pregnant women who needed more than 30 min to reach their maternity hospitals felt burden with high percentage.
    3.Current conditions of maternity hospitals
    Questionnaires were sent to and collected from obstetrical and/or gynecological hospitals in Chugoku and Shikoku areas. Almost half of the hospitals which had gynecological department did not have obstetrical department. Almost half of the hospitals which had gynecological department but not had obstetrical department had closed down the obstetrical department in the last 10 years. It was estimated that approximately 5 percentage of pregnant women needed more than 60 min for attending their maternity hospitals. Half of the obstetricians answered that a pregnant woman who needed more than 60 min for attending her maternity hospital was clinically risky.
    4.Conclusion
    Our research revealed that pregnant women living in the depopulated areas felt burdens for the distance to attend their maternity hospitals and that obstetricians was afraid pregnant women living in the depopulated areas would get into clinical trouble. It was suspected that the disparity of distribution of maternity hospitals between rural and urban area would expand more than now. However, this problem was less acknowledged than the problem of the emergency care sections of pediatrics departments. It is dispensable to inform the problems of maternity medicine in depopulated areas to the public, and to make regional plans that assures adequate distribution of maternity hospitals in collaboration with the national and/or local governments.

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  • Experimental study on the effects of organic solvent exposure to development of GABAergic system in juvenile rats

    Grant number：15590512  2003 - 2004

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ITO Takehiko

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    Grant amount：\2800000 （ Direct expense: \2800000 ）

    1.Development of an exposure system suitable for exposing vapor of organic solvents to juvenile animals (rats) and inhalation study using the system
    An exposure system suitable for exposing vapor of organic solvents to juvenile animals was developed.
    The inner environment of the exposure chamber was designed for young rats. An ordinary mice cage with gas inlets and outlets was completely wrapped with a special gas-tight plastic bag, which was then used as the exposure chamber. With this system, inhalation study in three-week old rats was conducted. The protocol of the exposure was as follows : m-xylene at 250 ppm, 6 h/day for 14 consecutive days.
    2.Behavioral study
    Rotarod test was employed to see the effect of m-xylene of the development of the CNS. Generally co-ordination of the motor system is assessed with this test. Exposed rats showed better coordination than controls, and further study is warranted to explain the unexpected results.
    3.Histological study
    Brain sections were made after the series of exposures. The section was stained using Luxol Fast Blue and Cresyl Violet double stain, to see possible lesions involving myelin. No significant change was observed. Immunohistochemical studies using anti-glutamate decarboxylase antibody and anti-GABA_A receptor alpha 6 subunit antibody were done, but no significant change was pointed out.
    Receptor binding autoradiography using [^3H]Ro15-4513 was performed. The distribution of the binding was identical to that of signals in immunostain of GABA_A receptor alpha 6 subunit. No significant change was observed.
    The present results suggested that there may be some significant change in locomotor function with this exposure protocol. A study in catecholaminergic and/or serotonergic system should be included along with that in GABAergic systems in the future studies.

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  • Distribution of Exposed Organic Solvent in the Brain and its Effect on GABA_A Receptor

    Grant number：12670356  2000 - 2001

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ITO Takehiko

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    Grant amount：\2600000 （ Direct expense: \2600000 ）

    1. Establishment of a new system for exposing organic solvents to small animals
    A system suitable for exposing m-xylene to rats was made, and a series of experiments was conducted using this system. The exposure system was easy to handle, and was useful.
    2. Effects of m-xylene exposure on GABA_A receptor in the brain
    Autoradiographic study was done using three ligands specific to GABA_A receptors. Autoradiography using [^<35>S]t-butylbicyclophosphorothionate revealed a significant increase in the binding in the cerebellum, whereas that using [^3H]flunitrazepam showed no significant changes. To further investigate the possibility of a receptor subunit-specific effect of m-xylene, autoradiogram using [^3H]Ro15-4513 was obtained. Significant changes in binding were found in the II-IIIth layer of the cerebral cortex, CA1, Inferior colliculus and in the granule cells of the cerebellum. The increase in the binding in the granule cells seemed to be a subunit-specific change, possibly due to alteration in alpha6 subunit-containing receptors.
    3. Measurement of m-xylene concentration in several areas of the brain
    The levels of m-xylene on and after the exposure were measured, and referenced with its metabolite concentration in urine.
    4. Measurement of m-methylhippuric acid in urine on and after the exposure
    The levels of m-methylhippuric acid were measured on and after the exposure. While m-xylene level and m-methylhippuric acid level paralleled during the exposure, the two levels decreased in a different manner after the exposure.
    These findings taken together, the basic data to develop a new biological effect monitoring of m-xylene were obtained. The new biological monitoring method will use changes in GABA_A receptor as indices of biological effect, and metabolite of m-xylene in urine (m-methylhippuric acid and/or its precursor m-tolualdehyde) as indices of the exposure, respectively.

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  • Development of a method for measurement of a time-weighted average concentration of polycyclic mutagens in marine environment-for practiced utilization in monitoring of marine environment.

    Grant number：11557030  1999 - 2000

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B).  Grant-in-Aid for Scientific Research (B).

    KIRA Shohei, ITO Takehiko, HAYATSU Hikoya, NOGAMI Yusaku, FUJISAWA Kuniyasu, KOMATSU Teruhisa

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    Grant amount：\9100000 （ Direct expense: \9100000 ）

    (1) Results of measuring the time-weighted average (TWA) concentration of Benzo (a) pyrene (BaP) in the Seto Inland Sea, Japan.
    The values of the TWA concentration of BaP from 1999 to 2000 ranged from 0.16 to 8.77 ng/L for the sampling sites in Okayama seashore, from 0.08 to 7.04 ng/L for Osaka Bay sites and from undetectable level (0.01 ng/L) to 18.88 ng/L for the sites in Northern Kyushu.
    (2) Effects of water temperature on the decrease in weight of plaster balls.
    We gave a dissolving test by hanging a plaster ball in moving water and found that the decrease in weight of the plaster ball correlated well with water flow intensity, and the regression coefficient and the intercept of regression line were affected by water temperature. We obtained the following equation :
    C={ΔW-(0.1232T+0.2247)}/(0.0189T+0.8162)
    where C is water flow intensity (cm/sec), ΔW is the decrease in weight of plaster ball (g) and T is water temperature (℃) and Therefore, according to this equation, it becomes possible to correct the value of measured TWA if water temperature is known.
    (3) Preserving condition of blue rayon after hanging and the recovery rate of BaP.
    One nanogram of BaP was dissolved in distilled water in a beaker and let BaP adsorbed to BR.We then calculated the recovery rate from amount of BaP after keeping it under various conditions against the initial one that was obtained from extraction without preservation. They were 101.6±8.2% (for one week) and 100.0±6.8% (for two weeks) when BR was preserved with aluminium-foil-wrapping at -5℃, and 93.5±5.1% (for four weeks) when preserved with transparent-plastic-foil-wrapping at 15-2O℃. The amount of the BaP adsorbed to BR has maintained over 90% even in the room temperature. Our study provides a convenient and a practical procedure for long-distance transportation of the samples.
    (4) Relationship between the amount of BaP and mutagenicity in samples after BR hanging.
    We have reported that mutagenicity detected by fhe BR hanging technique positively correlated with the amount of BaP.The present study unexpectedly found some samples despite of small amount of BaP showed high mutagenicity. Most of these phenomena were observed on the samples hanging in estuaries of the rivers flowing through the cities. This fact suggests that the city sewages might contain highly mutagenic substances except for BaP.
    (5) Publications and presentation of the study.
    We have published and presented the study results in scientific journals and at some conferences (see references). Furthermore, we are preparing for presentations at following international symposiums in order to receive various evaluations from foreign scientists : (1) PRIMO11 (July 2001, Plymouth, UK), (2) ISTA10 (August 2001, Quebec, Canada), (3) 8thICEM (October 2001, Shizuoka, Japan).

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  • 有機溶剤(シンナー等)乱用のモデル動物の作成とその特性に関する研究

    Grant number：10770168  1998 - 1999

    日本学術振興会  科学研究費助成事業 奨励研究(A)  奨励研究(A)

    伊藤 武彦

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    Grant amount：\1800000 （ Direct expense: \1800000 ）

    本研究では、シンナー乱用の生体に及ぼす影響を検討するために以下のことを行った:
    1.再現性がよく定量的な実験が可能な曝露実験系を開発した
    曝露実験装置を作成し、装置の基礎的な特性に関する検討をおこなった。その結果、最大約2200ppmのm-xylene蒸気を含んだ空気を長時間にわたり実験動物(ラット)に対して安定して曝露できる再現性のよい実験系を開発した。この装置は気化器に装てんする有機溶剤を変更することにより種々の実験を遂行することが可能な点で汎用性があり、有用である。
    2.新たに開発した実験系を用いて、m-xyleneとその代謝産物の生体内分布を測定し、またGABA_A受容体の変化を画像化して検討した
    この曝露実験系を用いてラットに有機溶剤(2000ppmのm-xyleneを一日4時間連続五日間)を曝露する実験を行った。曝露濃度は、乱用時の吸入濃度を想定して設定した。曝露後に、各臓器への有機溶剤の分布を検討したところ、脂質含量の多い組織(脳、脂肪組織など)に多く分布していた。脳内では小脳内の濃度が最も高く、大脳のほぼ二倍であり、m-xyleneは不均一に分布することがわかった。また、代謝産物も各臓器で測定した。さらに、GABA_A受容体の分布を[^<35>S]TBPSを用いたオートラジオグラフィー法で画像化したところ、小脳においてリガンド結合量が増加していた。小脳はm-xyleneが最も高濃度であったことからGABA_A受容体の発現はm-xyleneの曝露により変化することが示唆された。この点は報告が見当たらない知見であり、現在運動失調との関連性を調べるとともに、受容体遺伝子の発現の状況など、分子レベルの検討を急いでいる。
    3.研究成果の教材への活用
    実験の過程において薬物乱用防止教育の教材として活用しうる画像等が得られたので、研究代表者の担当する授業等で積極的に用いた。

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  • Pharmacological and molecular mechanisms on amino acid receptor complexes in brain of animal model for drug abuse

    Grant number：10670889  1998 - 1999

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    SUZUKI Toshihito, ITO Takehiko, BABA Atsuomi, SHIRAISHI Hiroyasu

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    Grant amount：\3000000 （ Direct expense: \3000000 ）

    The effects of intermittent intraperitoneal (i.p.) administration of cocaine (20 mg/kg) on GABAィイD2AィエD2-benzodiazepine (BZD) receptors labeled by t-[ィイD135ィエD1S] butylbicyclophophorothionate (TBPS), and on several types of mRNA subunits were investigated in rat brain by in vitro quantitative receptor autoradiography and in situ hybridization. Phosphor screen imaging with high sensitivity and a wide linear range of response was utilized for imaging analysis. There was a significant decrease in the level of α1, α6, β2, β3, and γ2 subunits mRNA with no alteration of [ィイD135ィエD1S] TBPS binding in any regions in the brain of rats, at 1 hour following a single injection of cocaine. In chronically treated-animals, the mean scores of stereotyped behavior were increased with the number of injections. The level of β3 subunit mRNA was decreased in the cortices and caudate-putamen, at 24 hours after a final injection of chronic administrations for 14 days. In the withdrawal from cocaine, the frontal cortex and hippocampal complexes showed a significant increase in [ィイD135ィエD1S] TBPS binding and α1 and β3 subunit mRNA in the rats 1 week after a cessation of chronic administration of cocaine. These findings suggest that the disruption of GABAィイD2AィエD2-BZD receptor formation is closely involved in the development of cocaine-related behavioral disturbances. Further studies on the physiological functions on GABAィイD2AィエD2-BZD receptor complex will be necessary for an explanation of the precise mechanisms underlying the acute effects, development of hypersensitization, and withdrawal state of cocaine.

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  • Developmental Studies and Support IV(Basis of School Health Science B) （2022academic year） Second semester  - 木5,木6

  • Basic Pharmacology （2022academic year） 1st and 2nd semester  - 金5,金6

  • Basic Pharmacology （2022academic year） 1st and 2nd semester  - 金5～6

  • Seminar in School Health Care and Education （2022academic year） 1st-4th semester  - その他

  • Basic Human Anatomy (1) （2021academic year） 1st semester  - 金7,金8

  • Basic Human Anatomy (2) （2021academic year） Second semester  - 金7,金8

  • Basic Human Anatomy A （2021academic year） 1st semester  - 金7,金8

  • Basic Human Anatomy B （2021academic year） Second semester  - 金7,金8

  • Hands on Instruction on Anatomy and Physiology II （2021academic year） Summer concentration  - その他

  • Seminar　in　Basic Physiology （2021academic year） Summer concentration  - その他

  • Basic Human Physiology A （2021academic year） Third semester  - 金3,金4

  • Basic Human Physiology B （2021academic year） Fourth semester  - 金3,金4

  • Basic Physiology I (1) （2021academic year） Third semester  - 金3,金4

  • Basic Physiology I (2) （2021academic year） Fourth semester  - 金3,金4

  • Lecture on Human Body Structure, Function and Diseases a （2021academic year） 1st semester  - 金7～8

  • Lecture on Human Body Structure, Function and Diseases b （2021academic year） Second semester  - 金7～8

  • Public Health and Hygiene (1) （2021academic year） 1st semester  - 月7,月8

  • Public Health and Hygiene (2) （2021academic year） Second semester  - 月7,月8

  • Public Health and Hygiene A （2021academic year） 1st semester  - 月7,月8

  • Public Health and Hygiene B （2021academic year） Second semester  - 月7,月8

  • Public Health and Hygiene C （2021academic year） Third semester  - 金5～6

  • Approaches to Education （2021academic year） 1st semester  - 火1～2

  • School Health II (1) （2021academic year） 1st semester  - 木7～8

  • School Health II (2) （2021academic year） Second semester  - 木7～8

  • School Health / School Safety and Risk Management A （2021academic year） 1st semester  - 火1,火2

  • School Health / School Safety and Risk Management B （2021academic year） Second semester  - 火1,火2

  • Special Studies in School Health Science(Environment and Health A): Seminar （2021academic year） Third semester  - 木7,木8

  • Special Studies in School Health Science(Environment and Health B): Seminar （2021academic year） Fourth semester  - 木7,木8

  • Special Studies in School Health Science(Environment and Health A) （2021academic year） Third semester  - 木5,木6

  • Special Studies in School Health Science(Environment and Health B) （2021academic year） Fourth semester  - 木5,木6

  • Seminar in School Health A （2021academic year） 1st semester  - 木7～8

  • Seminar in School Health B （2021academic year） Second semester  - 木7～8

  • Seminar in Teaching Profession Practice (Secondary school B) （2021academic year） special  - その他

  • Seminar in Teaching Profession Practice （2021academic year） special  - その他

  • Methodologies of Educational Practical Research IA （2021academic year） 1st semester  - 木1,木2

  • Methodologies of Educational Practical Research IA （2021academic year） Second semester  - 木1,木2

  • Project Research in Educational Science （2021academic year） 1st-4th semester  - その他

  • Basic of Special Needs Education Ｃ （2021academic year） 1st semester  - 火5,火6

  • Environment and Health （2021academic year） Fourth semester  - 木1～2

  • Epidemiology and Hygiene （2021academic year） Fourth semester  - 金5～6

  • Epidemiology and Hygiene (1) （2021academic year） Third semester  - 金5,金6

  • Epidemiology and Hygiene (2) （2021academic year） Fourth semester  - 金5,金6

  • Developmental Studies and Support IV(Basis of School Health Science A) （2021academic year） 1st semester  - 木5,木6

  • Developmental Studies and Support IV(Basis of School Health Science B) （2021academic year） Second semester  - 木5,木6

  • Basic Pharmacology （2021academic year） 1st and 2nd semester  - 金5,金6

  • Basic Pharmacology （2021academic year） 1st and 2nd semester  - 金5～6

  • Seminar in School Health Care and Education （2021academic year） special  - その他

  • Basic Human Anatomy (1) （2020academic year） 1st semester  - 金7,金8

  • Basic Human Anatomy (2) （2020academic year） Second semester  - 金7,金8

  • Basic Human Anatomy A （2020academic year） 1st semester  - 金7,金8

  • Basic Human Anatomy B （2020academic year） Second semester  - 金7,金8

  • Hands on Instruction on Anatomy and Physiology II （2020academic year） Summer concentration  - その他

  • Seminar　in　Basic Physiology （2020academic year） Summer concentration  - その他

  • Basic Human Physiology A （2020academic year） Third semester  - 金3,金4

  • Basic Human Physiology B （2020academic year） Fourth semester  - 金3,金4

  • Basic Physiology I (1) （2020academic year） Third semester  - 金3,金4

  • Basic Physiology I (2) （2020academic year） Fourth semester  - 金3,金4

  • Lecture on Human Body Structure, Function and Diseases a （2020academic year） 1st semester  - 金7,金8

  • Lecture on Human Body Structure, Function and Diseases b （2020academic year） Second semester  - 金7,金8

  • Public Health and Hygiene (1) （2020academic year） 1st semester  - 月7,月8

  • Public Health and Hygiene (2) （2020academic year） Second semester  - 月7,月8

  • Public Health and Hygiene A （2020academic year） 1st semester  - 月7,月8

  • Public Health and Hygiene B （2020academic year） Second semester  - 月7,月8

  • School Health / School Safety and Risk Management A （2020academic year） 1st semester  - 火1,火2

  • School Health / School Safety and Risk Management B （2020academic year） Second semester  - 火1,火2

  • Special Studies in School Health Science(Environment and Health A): Seminar （2020academic year） Third semester  - 木7,木8

  • Special Studies in School Health Science(Environment and Health B): Seminar （2020academic year） Fourth semester  - 木7,木8

  • Special Studies in School Health Science(Environment and Health A) （2020academic year） Third semester  - 木5,木6

  • Special Studies in School Health Science(Environment and Health B) （2020academic year） Fourth semester  - 木5,木6

  • Seminar in Teaching Profession Practice (Secondary school B) （2020academic year） special  - その他

  • Seminar in Teaching Profession Practice （2020academic year） 1st-4th semester  - 月5,月6,月7,月8

  • Methodologies of Educational Practical Research IA （2020academic year） 1st semester  - 木1,木2

  • Methodologies of Educational Practical Research IA　 （2020academic year） Second semester  - 木1,木2

  • Project Research in Educational Science （2020academic year） 1st-4th semester  - その他

  • Environment and Health （2020academic year） Fourth semester  - 木1,木2

  • Epidemiology and Hygiene (1) （2020academic year） Third semester  - 金5,金6

  • Epidemiology and Hygiene (2) （2020academic year） Fourth semester  - 金5,金6

  • Developmental Studies and Support IV(Basis of School Health Science A) （2020academic year） 1st semester  - 木5,木6

  • Developmental Studies and Support IV(Basis of School Health Science B) （2020academic year） Second semester  - 木5,木6

  • Basic Pharmacology （2020academic year） 1st and 2nd semester  - 金5,金6

  • Seminar in School Health Care and Education （2020academic year） special  - その他

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