Updated on 2021/12/16

写真a

 
MITSUNOBU Fumihiro
 
Organization
Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • Doctor(Medical Science) ( Okayama University )

Research Interests

  • spa therapy

  • Chronic obstructive pulmonary disease

  • Bronchial asthma

  • 温泉療法

  • 慢性閉塞性肺疾患

  • 気管支喘息

Research Areas

  • Environmental Science/Agriculture Science / Chemical substance influence on environment

  • Environmental Science/Agriculture Science / Radiation influence

  • Life Science / Rehabilitation science

  • Life Science / Respiratory medicine

Education

  • Okayama University    

    - 1988

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  • Okayama University   医学研究科   腫瘍生化学

    - 1988

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    Country: Japan

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  • Okayama University    

    - 1984

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  • Okayama University   医学部   医学科

    - 1984

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    Country: Japan

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Research History

  • - 岡山大学医歯薬学総合研究科 教授

    2008

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  • - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2008

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  • Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2002 - 2008

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  • 岡山大学医歯薬学総合研究科 准教授

    2002 - 2008

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2001 - 2008

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  • Associate Professor,Okayama Univiersity Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2001 - 2008

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  • Associate Professor,University Hospital of Medicine and Dentistry,Okayama University

    2001 - 2002

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  • Okayama University   Okayama University Hospital

    2001 - 2002

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  • Senior Assistant Professor,University Hospital of Medicine and Dentistry,Okayama University

    1994 - 2001

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  • Okayama University   Okayama University Hospital

    1994 - 2001

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  • Research Associate,University Hospital of Medicine and Dentistry,Okayama University

    1990 - 1994

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  • Okayama University   Medical School

    1990 - 1994

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  • Okayama University   Okayama University Hospital

    1990 - 1994

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  • Research Associate

    1990 - 1994

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  • 南カリフォルニア大学医学部研究員 未設定

    1988 - 1990

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Professional Memberships

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Committee Memberships

  • 日本アレルギー学会   代議員  

    2020.10   

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  • 日本温泉気候物理医学会   理事  

    2019.5   

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    Committee type:Academic society

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  • 日本呼吸器学会   代議員  

    2015   

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    Committee type:Academic society

    日本呼吸器学会

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  • 日本アレルギー学会   代議員  

    2015   

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    Committee type:Academic society

    日本アレルギー学会

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  • 日本アレルギー学会   喘息ガイドライン専門部会  

    2009   

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    Committee type:Academic society

    日本アレルギー学会

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  • 日本温泉気候物理医学会   理事  

    2009   

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    Committee type:Academic society

    日本温泉気候物理医学会

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  • 日本温泉気候物理医学会   評議員  

    2008   

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    Committee type:Academic society

    日本温泉気候物理医学会

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  • 日本内科学会   中国地方会代議員  

    2005   

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    Committee type:Academic society

    日本内科学会

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  • 日本老年医学会   代議員  

    2000.6   

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    Committee type:Academic society

    日本老年医学会

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Papers

  • Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model Reviewed

    Takahiro Kataoka, Shota Naoe, Kaito Murakami, Ryohei Yukimine, Yuki Fujimoto, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of Clinical Biochemistry and Nutrition   2022

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Society for Free Radical Research Japan  

    DOI: 10.3164/jcbn.21-91

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  • Erratum to: Evaluation of the redox state in mouse organs following radon inhalation. Reviewed International journal

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of radiation research   62 ( 5 )   945 - 945   2021.9

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  • Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions. Reviewed International journal

    Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

    Journal of radiation research   62 ( 5 )   861 - 867   2021.8

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    Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.

    DOI: 10.1093/jrr/rrab069

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  • Dosimetry of radon progeny deposited on skin in air and thermal water. Reviewed International journal

    Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Journal of radiation research   62 ( 4 )   634 - 644   2021.5

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    It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. An interesting proposal has emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of this study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or treatment assessments. We thus first estimated the skin deposition velocities of radon progeny in air and thermal water based on data from the latest human studies. Skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e. basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to 'radon exposure' was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.

    DOI: 10.1093/jrr/rrab030

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  • Evaluation of the redox state in mouse organs following radon inhalation. "jointly worked" Reviewed International journal

    Kataoka T, Kanzaki N, Sakoda A, Shuto H, Yano J, Naoe S, Tanaka H, Hanamoto K, Terato H, Mitsunobu F, Yamaoka K

    JOURNAL OF RADIATION RESEARCH   62 ( 2 )   206 - 216   2021.1

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    Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m3 for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.

    DOI: 10.1093/jrr/rraa129

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  • Evaluation of the redox state in mouse organs following radon inhalation

    「Kataoka T」「Kanzaki N」「Sakoda A」「Shuto H」「Yano J」「Naoe S」「Tanaka H」「Hanamoto K」「Terato H」「Mitsunobu F」「Yamaoka K」

    Journal of Radiation Research (J Radiat Res.)   62 ( 2 )   206 - 216   2021.1

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    DOI: 10.1093/jrr/rraa129

    Other Link: https://academic.oup.com/jrr

  • Comparison of antioxidative effects between radon and thoron inhalation in mouse organs. Reviewed International journal

    Kobashi Y, Kataoka T, Kanzaki N, Ishida T, Sakoda A, Tanaka H, Ishimori Y, Mitsunobu F, Yamaoka K

    Radiation and environmental biophysics   59 ( 3 )   473 - 482   2020.8

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    Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

    DOI: 10.1007/s00411-020-00843-0

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  • Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Reviewed International journal

    Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

    Journal of radiation research   58 ( 5 )   614 - 625   2017.9

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    Radon therapy using radon (222Rn) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Mice inhaled radon at a concentration of 2000 Bq/m3 for 24 h or were provided with hot spring water for 2 weeks. The activity density of 222Rn ranged from 663 Bq/l (start point of supplying) to 100 Bq/l (end point of supplying). Mice were then orally administered ethanol at three concentrations. The ulcer index (UI), an indicator of mucosal injury, increased in response to the administration of ethanol; however, treatment with either radon inhalation or hot spring water inhibited the elevation in the UI due to ethanol. Although no significant differences in antioxidative enzymes were observed between the radon-treated groups and the non-treated control groups, lipid peroxide levels were significantly lower in the stomachs of mice pre-treated with radon or hot spring water. These results suggest that hot spring water drinking and radon inhalation inhibit ethanol-induced gastric mucosal injury.

    DOI: 10.1093/jrr/rrx021

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  • Measurements of radon activity concentration in mouse tissues and organs. Reviewed International journal

    Ishimori Y, Tanaka H, Sakoda A, Kataoka T, Yamaoka K, Mitsunobu F

    Radiation and environmental biophysics   56 ( 2 )   161 - 165   2017.5

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    The purpose of this study is to investigate the biokinetics of inhaled radon, radon activity concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m3 of radon in air. Radon activity concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon activity concentration in mouse blood was 0.410 ± 0.016 Bq/g when saturated with 1 MBq/m3 of radon activity concentration in air. In addition, average partition coefficients obtained were 0.74 ± 0.19 for liver, 0.46 ± 0.13 for muscle, 9.09 ± 0.49 for adipose tissue, and 0.22 ± 0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon activity concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.

    DOI: 10.1007/s00411-017-0682-9

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  • Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice. Reviewed International journal

    Etani R, Kataoka T, Kanzaki N, Sakoda A, Tanaka H, Ishimori Y, Mitsunobu F, Yamaoka K

    Journal of radiation research   57 ( 3 )   250 - 7   2016.6

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    Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.

    DOI: 10.1093/jrr/rrw014

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  • Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial. "jointly worked" Reviewed

    KIkuchi H, Shiozawa N, Takata S, Ashida K, Mitsunobu F

    9   9 - 15   2014.1

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    DOI: 10.2147/COPD.S50860.

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  • Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial. Reviewed International journal

    Hiroshi Kikuchi, Nobuyoshi Shiozawa, Shingo Takata, Kozo Ashida, Fumihiro Mitsunobu

    International journal of chronic obstructive pulmonary disease   9   9 - 15   2014

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    PURPOSE: Controlled clinical trials evaluating the efficacy of repeated Waon therapy for patients with chronic obstructive pulmonary disease (COPD) have yet to be conducted. The purpose of the present study was to evaluate whether repeated Waon therapy exhibits an adjuvant effect on conventional therapy for COPD patients. PATIENTS AND METHODS: This prospective trial comprised 20 consecutive COPD patients who satisfied the criteria of the Global initiative for chronic Obstructive Lung Disease (GOLD) guidelines, stages 1-4. They were assigned to either a Waon or control group. The patients in the Waon group received both repeated Waon therapy and conventional therapy, including medications, such as long-acting inhaled β2 agonists, long-acting anticholinergics and xanthine derivatives, and pulmonary rehabilitation. The Waon therapy consisted of sitting in a 60°C sauna room for 15 minutes, followed by 30 minutes of being warmed with blankets once a day, 5 days a week, for a total of 20 times. The patients in the control group received only conventional therapy. Pulmonary function and the 6-minute walk test were assessed before and at 4 weeks after the program. RESULTS: The change in vital capacity (0.30 ± 0.4 L) and in peak expiratory flow (0.48 ± 0.79 L/s) in the Waon group was larger than the change in the vital capacity (0.02 ± 0.21 L) (P=0.077) and peak expiratory flow (-0.11 ± 0.72 L/s) (P=0.095) in the control group. The change in forced expiratory flow after 50% of expired forced vital capacity in the Waon group, 0.08 (0.01-0.212 L/s), was larger than that in the control group, -0.01 (-0.075-0.04 L/s) (P=0.019). Significant differences were not observed in the change in any parameters in the 6-minute walk test. Data are presented as means ± standard deviation or median (25th-75th percentile). CONCLUSION: The addition of repeated Waon therapy to conventional therapy for COPD patients can possibly improve airway obstruction.

    DOI: 10.2147/COPD.S50860

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  • Absorbed doses of lungs from radon retained in airway lumens of mice and rats. Reviewed International journal

    Sakoda A, Ishimori Y, Yamaoka K, Kataoka T, Mitsunobu F

    Radiation and environmental biophysics   52 ( 3 )   389 - 95   2013.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    This paper provides absorbed doses arising from radon gas in air retained in lung airway lumens. Because radon gas exposure experiments often use small animals, the calculation was performed for mice and rats. For reference, the corresponding computations were also done for humans. Assuming that radon concentration in airway lumens is the same as that in the environment, its progeny's production in and clearance from airways were simulated. Absorbed dose rates were obtained for three lung regions and the whole lung, considering that secretory and basal cells are sensitive to radiation. The results showed that absorbed dose rates for all lung regions and whole lung generally increase from mice to rats to humans. For example, the dose rates for the whole lung were 25.4 in mice, 41.7 in rats, and 59.9 pGy (Bq m⁻³)⁻¹ h⁻¹ in humans. Furthermore, these values were also compared with lung dose rates from two other types of exposures, that is, due to inhalation of radon or its progeny, which were already reported. It was confirmed that the direct inhalation of radon progeny in the natural environment, which is known as a cause of lung cancer, results in the highest dose rates for all species. Based on the present calculations, absorbed dose rates of the whole lung from radon gas were lower by a factor of about 550 (mice), 200 (rats), or 70 (humans) than those from radon progeny inhalation. The calculated dose rate values are comparatively small. Nevertheless, the present study is considered to contribute to our understanding of doses from inhalation of radon and its progeny.

    DOI: 10.1007/s00411-013-0478-5

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  • Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation. Reviewed International journal

    Y Nishiyama, T Kataoka, J Teraoka, A Sakoda, H Tanaka, Y Ishimori, F Mitsunobu, T Taguchi, K Yamaoka

    Physiological research   62 ( 1 )   57 - 66   2013

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    We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas.

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  • Lung dosimetry of inhaled radon progeny in mice. Reviewed International journal

    Sakoda A, Ishimori Y, Fukao K, Yamaoka K, Kataoka T, Mitsunobu F

    Radiation and environmental biophysics   51 ( 4 )   425 - 42   2012.11

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    Biological response of exposure to radon progeny has long been investigated, but there are only few studies in which absorbed doses in lungs of laboratory animals were estimated. The present study is the first attempt to calculate the doses of inhaled radon progeny for mice. For reference, the doses for rats and humans were also computed with the corresponding models. Lung deposition of particles, their clearance, and energy deposition of alpha particles to sensitive tissues were systematically simulated. Absorbed doses to trachea and bronchi, bronchioles and terminal bronchioles, alveolar-interstitial regions, and whole lung were first provided as a function of monodisperse radon progeny particles with an equilibrium equivalent radon concentration of 1 Bq m(-3) (equilibrium factor, 0.4 and unattached fraction, 0.01). Based on the results, absorbed doses were then calculated for (1) a reference mine condition and (2) a condition previously used for animal experiments. It was found that the whole lung doses for mice, rats, and humans were 34.8, 20.7, and 10.7 nGy (Bq m(-3))(-1) h(-1) for the mine condition, respectively, while they were 16.9, 9.9, and 6.5 nGy (Bq m(-3))(-1) h(-1) for the animal experimental condition. In both cases, the values for mice are about 2 times higher than those for rats, and about 3 times higher than those for humans. Comparison of our data on rats and humans with those published in the literature shows an acceptable agreement, suggesting the validity of the present modeling for mice. In the future, a more sophisticated dosimetric study of inhaled radon progeny in mice would be desirable to demonstrate how anatomical, physiological, and environmental parameters can influence absorbed doses.

    DOI: 10.1007/s00411-012-0431-z

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  • Study on effects of thoron and thermal treatment for aging-related diseases in humans Reviewed

    Aoyama Y, Kataoka T, Nakagawa Sh, Sakoda A, Ishimori Y, Mitsunobu F, Yamaoka K

    IRANIAN JOURNAL OF RADIATION RESEARCH   9 ( 4 )   221 - 229   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IJRR-IRANIAN JOURNAL RADIATION RES  

    Background: The aim of this study was to analyze the effects of thoron and thermal treatment for aging-related diseases in humans. Materials and Methods: All subjects inhaled thoron with a high concentration (about 4900 Bq/m(3)) for 2 weeks. Blood pressures were measured and blood samples were collected after each treatment 1, 2 and 3 weeks after the first treatment. Results: The alpha-atrial natriuretic peptide level of the rheumatoid arthritis group was increased and the blood pressure was significantly decreased. Superoxide dismutase activity of rheumatoid arthritis group was significantly increased by treatment. In addition, thoron and thermal treatment significantly enhanced the concanavalin A-induced mitogen response and increased the level of CD4-positive cells; it decreased the level of CD8-positive cells. The results suggest that thoron and thermal treatment activates antioxidative function. Furthermore, these findings suggest that thoron and thermal treatment prevents diabetic ketoacidosis and contributes to the prevention of aging-related diseases. Conclusion: Thoron and thermal therapy may be part of the mechanism for the alleviation of diabetes mellitus and rheumatoid arthritis. Iran. J. Radiat. Res., 2012; 9(4): 221-229

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  • Performance of the first Japanese large-scale facility for radon inhalation experiments with small animals. Reviewed International journal

    Ishimori Y, Mitsunobu F, Yamaoka K, Tanaka H, Kataoka T, Sakoda A

    Radiation protection dosimetry   146 ( 1-3 )   31 - 3   2011.7

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    A radon test facility for small animals was developed in order to increase the statistical validity of differences of the biological response in various radon environments. This paper illustrates the performances of that facility, the first large-scale facility of its kind in Japan. The facility has a capability to conduct approximately 150 mouse-scale tests at the same time. The apparatus for exposing small animals to radon has six animal chamber groups with five independent cages each. Different radon concentrations in each animal chamber group are available. Because the first target of this study is to examine the in vivo behaviour of radon and its effects, the major functions to control radon and to eliminate thoron were examined experimentally. Additionally, radon progeny concentrations and their particle size distributions in the cages were also examined experimentally to be considered in future projects.

    DOI: 10.1093/rpd/ncr100

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  • Study of the response of superoxide dismutase in mouse organs to radon using a new large-scale facility for exposing small animals to radon. Reviewed International journal

    Kataoka T, Sakoda A, Ishimori Y, Toyota T, Nishiyama Y, Tanaka H, Mitsunobu F, Yamaoka K

    Journal of radiation research   52 ( 6 )   775 - 81   2011

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN RADIATION RESEARCH SOC  

    We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose-rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.

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  • A comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse Reviewed

    Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Teruaki Toyota, Yuki Yamamoto, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Radiation Safety Management   10 ( 1 )   1 - 7   2011

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    DOI: 10.12950/rsm.10.1

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  • Lung function and blood markers of nutritional status in non-COPD aging men with smoking history: a cross-sectional study. Reviewed International journal

    Shiozawa N, Hayashimoto K, Suzuki E, Kikuchi H, Takata S, Ashida K, Watanabe M, Hosaki Y, Mitsunobu F

    International journal of chronic obstructive pulmonary disease   5   233 - 40   2010.8

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    PURPOSE: Cigarette smoking and advanced age are well known as risk factors for chronic obstructive pulmonary disease (COPD), and nutritional abnormalities are important in patients with COPD. However, little is known about the nutritional status in non-COPD aging men with smoking history. We therefore investigated whether reduced lung function is associated with lower blood markers of nutritional status in those men. SUBJECTS AND METHODS: This association was examined in a cross-sectional study of 65 Japanese male current or former smokers aged 50 to 80 years: 48 without COPD (non-COPD group), divided into tertiles according to forced expiratory volume in one second as percent of forced vital capacity (FEV(1)/FVC), and 17 with COPD (COPD group). RESULTS: After adjustment for potential confounders, lower FEV(1)/FVC was significantly associated with lower red blood cell count (RBCc), hemoglobin, and total protein (TP); not with total energy intake. The difference in adjusted RBCc and TP among the non-COPD group tertiles was greater than that between the bottom tertile in the non-COPD group and the COPD group. CONCLUSION: In non-COPD aging men with smoking history, trends toward reduced nutritional status and anemia may independently emerge in blood components along with decreased lung function even before COPD onset.

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  • Effect of spa Therapy on the six-minute Walk Test in patients with chronic obstructive pulmonary disease Reviewed

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    日本温泉気候物理医学会雑誌   71 ( 4 )   241 - 249   2008

  • 急性期病院におけるDischarege Planningを核とした「高齢者・在宅・緩和医療プロフェショナル養成コース」の概要 Reviewed

    小松裕和, 光延文裕, 土居弘幸, 小出典男

    岡山医学会雑誌   120 ( 1 )   1 - 5   2008

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  • The effects of spa therapy combined with dietary supplementation with n-3 fatty acids on serum eosinophil cationic protein in asthmatic subject. Reviewed

    Takata S, Ashida K, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Mitsunobu F

    J Jpn Assoc Phys Med Balneol Climatol   2006

  • Effect of foot baths containing artificial CO2 on peripheral circulation. Reviewed

    Hosaki Y, Ashida K, Hamada M, Fujii M, Iwagaki N, Takata S, Tabuki K, Mitsunobu F

    J Jpn Assoc Phys Med Balneol Climatol   2006

  • The elevation of p53 protein level and SOD activity in the resident blood of the Misasa radon hot spring district. Reviewed International journal

    Kiyonori Yamaoka, Fumihiro Mitsunobu, Shuji Kojima, Misako Shibakura, Takahiro Kataoka, Katsumi Hanamoto, Yoshiro Tanizaki

    Journal of radiation research   46 ( 1 )   21 - 4   2005.3

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    To clarify the mechanism by which radon hot springs prevent cancer or not, in this study, blood was collected from residents in the Misasa hot spring district and in a control district. The level of a representative cancer-suppressive gene, p53, and the activity of a representative antioxidant enzyme, superoxide dismutase (SOD), were analyzed as indices. The level of serum p53 protein in the males in the Misasa hot spring district was found to be 2-fold higher than that in the control district, which is a significant difference. In the females in the Misasa hot spring district, SOD activity was approximately 15% higher than that in the control district, which is also statistically significant, and exceeded the reference range of SOD activity despite advanced age. These results suggested that routine exposure of the residents in the Misasa hot spring district to radon at a concentration about 3 times higher than the national mean induces trace active oxygen in vivo, potentiating products of cancer-suppressive gene and antioxidant function. As the p53 protein level was high in the residents in the Misasa hot spring district, apoptosis of cancer cells may readily occur.

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  • The use of computed tomography to assess asthma severity. Reviewed International journal

    Fumihiro Mitsunobu, Yoshiro Tanizaki

    Current opinion in allergy and clinical immunology   5 ( 1 )   85 - 90   2005.2

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    PURPOSE OF REVIEW: Chronic inflammation in asthma can also lead to airway remodeling, which contributes to airway narrowing. It may be possible to assess and quantify the extent of airway remodeling in vivo using computed tomography. This review examines recent developments in the evaluation of asthma severity using computed tomography, and the effect of treatment assessed by computed tomography. RECENT FINDINGS: Asthma patients have thicker airways on computed tomography scans than do healthy control individuals, and the degree of thickening is related to the severity of disease, airflow obstruction, and airway reactivity. Recent studies have indicated that patients with severe asthma and irreversible airflow obstruction had longer disease duration, a greater inflammatory process and more airway abnormalities, assessed by high-resolution computed tomography, suggestive of airway remodeling. Other studies have shown that high-resolution computed tomography lung density correlates with airflow limitation and lung volume (but not with lung transfer factor), and also correlates with patient age and severity of asthma. More recently, two publications demonstrated the effect of treatment on airway wall thickness and lung density assessed by computed tomography in patients with asthma. SUMMARY: High-resolution computed tomography is one of the most useful tools for imaging airways and parenchyma. Computed tomography scanning may be useful in determining which patients might benefit from more or less treatment. With additional advances in technology, it is likely that quantitative assessment by computed tomography will ultimately be a valuable tool for the study and treatment of chronic airway diseases.

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  • Reduction in Costs of drugs Used for the Treatment of Asthma by Spa Therapy in Relation to Disease Severity Reviewed

    ASHIDA Kozo, MITSUNOBU Fumihiro, HOSAKI Yasuhiro, HAMADA Masanori, IWAGAKI Naohumi, FUJII Makoto, TAKATA Shingo, TANIZAKI Yoshiro

    The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine   68 ( 3 )   166 - 174   2005

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    Effects of long-term spa therapy on reduction of the costs of drugs used for the treatment were examined in 23 patients with asthma. The costs of drugs used per patient for 1 year when spa therapy started (1997) were compared with the costs used for 1 year after spa therapy for 3 years (2000). 1. The decrease in the total costs of all drugs was \31, 910 in patients with stage 1, \74, 900 in those with stage 2, \113, 450 in stage 3, and \180, 910 in stage 4. The % decrease of the costs of drugs used was 34.2% in stage 1, 46.3% in stage 2, 37.1% in stage 3, and 42.4% in stage 4. The results showed that the reduction in the costs of drugs tended to increase as asthma severity increased, and that the % decrease of the costs was higher in stage 2 and 4, in which the %decrease was more than 40%. 2. The reduction of costs of each drug, bronchodilators, glucocorticoids, antiallergic agents, mucolytics, and antibiotics after spa therapy, was significant in patients with stage 3 and stage 4, whose severity was considerably increased. However, the decrease in the costs of these drugs after spa therapy was not significant in patients with stage 1 and 2. The reduction of the costs more than 50% was observed in bronchodilators, antiallergic agents, mucolytics, and antibiotics in patients with stage 4, in whom the reduction of the costs of these drugs was significant. The results obtained here suggest that the costs of drugs used for asthma treatment could be reduced by spa therapy in patients with more increased severity.

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  • Effects of Spa Therapy for Asthmatics with a Long History of Cigarette Smoking, Evaluated by Bronchial Hyperresponsiveness and Generation of Leukotrienes by Leucocytes Reviewed

    MITSUNOBU Fumihiro, HOSAKI Yasuhiro, ASHIDA Kozo, IWAGAKI Naofumi, NAGATA Takuya, FUJII Makoto, TAKATA Shingo, HAMADA Masanori, TANIZAKI Yoshiro

    The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine   68 ( 2 )   83 - 91   2005

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    The effects of spa therapy for asthmatics with a long history of cigarette smoking were studied, compared with the effects for those without smoking history. 1. Of 22 patients with smoking history, 15 (68.2%) had definite efficacy of spa therapy (4 had marked efficacy, and 11 had moderate efficacy), and the residual 7 had slight or no efficacy. In contrast, of 36 patients without smoking history, 29 (80.6%) had definite efficacy. The effects of spa therapy for asthmatics were significantly higher in never-smokers than in ex-smokers.<br>2. A significant increase in the production of IgE antibodies, bronchial hyperresponsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes was observed in ex-smokers compared with never-smokers. 3. The frequency of patients with a positive BAST against inhalant allergens was larger in subjects with slight or no efficacy than in those with marked or moderate efficacy in never-smokers, but not in ex-smokers. 4. Bronchial hyperresponsiveness was significantly increased in patients with slight or no efficacy than in those with marked or moderate efficacy both in ex-smokers and never-smoker. 5. The generation of LTB4 was more increased in subjects with slight or no efficacy than in those with efficacy both in ex-smokers and never-smokers, however, the differences were not significant. 5. The generation of LTC4 tended to be more increased in subjects with slight or no efficacy than in those with efficacy in never-smokers, but not in ex-smokers, although these were not significant. The results suggest that an increase in the production of IgE antibodies, bronchial hyperresponsiveness, and the generation of LTB4 and LTC4, which might be influenced by cigarette smoking, affect the effects of spa therapy for patients with asthma.

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  • Effects of radon and thennal therapy on osteoarthritis Reviewed

    K Yamaoka, F Mitsunobu, K Hanamoto, T Kataoka, Y Tanizaki

    HIGH LEVELS OF NATURAL RADIATION AND RADON AREAS: RADIATION DOSE AND HEALTH EFFECTS   1276   249 - 250   2005

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    We examined the temporal changes in antioxidants, immune-, vasoactive- and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and that the changes in vasoactive and pain-associated substances indicate increases in tissue perfusion brought about by radon therapy. (c) 2004 Published by Elsevier B.V.

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  • Clinical Effects of Radon and Thermal Therapy for Respiratory Diseases

    MITSUNOBU Fumihiro

    The Journal of Japanese Balneo-Climatological Association   68 ( 1 )   20 - 22   2004.11

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    DOI: 10.11390/onki1962.68.20

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  • Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. Reviewed International journal

    Yamaoka K, Mitsunobu F, Hanamoto K, Shibuya K, Mori S, Tanizaki Y, Sugita K

    Journal of radiation research   45 ( 1 )   83 - 8   2004.3

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    The radioactive and thermal effects of radon hot spring were biochemically compared under a sauna room or hot spring conditions with a similar chemical component, using the parameters that are closely involved in the clinic for radon therapy. The results showed that the radon and thermal therapy enhanced the antioxidation functions, such as the activities of superoxide dismutase (SOD) and catalase, which inhibit lipid peroxidation and total cholesterol produced in the body. Moreover the therapy enhanced concanavalin A (ConA)-induced mitogen response and increased the percentage of CD4 positive cells, which is the marker of helper T cells, and decreased the percentage of CD8 positive cells, which is the common marker of killer T cells and suppressor T cells, in the white blood cell differentiation antigen (CD8/CD4) assay. Furthermore, the therapy increased the levels of alpha atrial natriuretic polypeptide (alpha ANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level. The results were on the whole larger in the radon group than in the thermal group. The findings suggest that radon therapy contributes more to the prevention of life-style-related diseases related to peroxidation reactions and immune suppression than to thermal therapy. Moreover, these indicate what may be a part of the mechanism for the alleviation of hypertension, osteoarthritis (pain), and diabetes mellitus brought about more by radon therapy than by thermal therapy.

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  • Study on biologic effects of radon and thermal therapy on osteoarthritis. Reviewed International journal

    Yamaoka K, Mitsunobu F, Hanamoto K, Mori S, Tanizaki Y, Sugita K

    The journal of pain : official journal of the American Pain Society   5 ( 1 )   20 - 5   2004.2

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    UNLABELLED: Radon therapy uses radon (222Rn) gas, which mainly emits alpha-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain. PERSPECTIVE: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis.

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  • Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. Reviewed International journal

    F Mitsunobu, K Ashida, Y Hosaki, H Tsugeno, M Okamoto, N Nishida, T Nagata, Y Tanizaki, M Tanimoto

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology   34 ( 1 )   59 - 64   2004.1

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    BACKGROUND: Smoking is the most important cause of chronic obstructive pulmonary disease (COPD). However, the influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempted to clarify the influence of cigarette smoking on elderly asthmatics. METHODS: Forty-eight asthmatics over 70 years old (25 ex-smokers and 23 never-smokers) and 20 patients with COPD over 70 years old (all ex-smokers) were studied to determine the influence of cigarette smoking on IgE-mediated allergy (total IgE, IgE antibodies against inhalant allergens, bronchial hyper-responsiveness (BHR), generation of leukotriene (LT) B4 and C4), pulmonary function, and the relative area of lung showing attenuation values less than -950 Hounsfield units (RA950) on high-resolution computed tomography scans. RESULTS: The incidence of positive IgE antibodies against inhalant allergens, BHR, and the generation of leukotriene B4 (LTB4) by leucocytes were significantly increased in patients with a history of smoking compared with those without. Residual volume (%RV) was significantly increased, and diffusing capacity for carbon monoxide was significantly decreased in ex-smokers with asthma and COPD compared with never-smokers with asthma. Inspiratory RA950 and ratio of expiratory RA950 to inspiratory RA950 were significantly larger in asthmatics with a smoking history than in those without, and in COPD patients than in asthmatics. CONCLUSION: Cigarette smoking enhances the production of IgE antibodies, BHR, and generation of LTB4 by leucocytes in elderly asthmatics. Increased hyper-inflation or emphysematous changes of the lungs expressed by increased RA950, closely related to %RV, was more frequently observed in ex-smokers compared with never-smokers.

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  • Five-year observation of the effects of spa therapy for patients with pulmonary emphysema, evaluated by %low attenuation area (%LAA) of the lungs on high resolution CT, %DLco, and % residual volume (RV). Reviewed

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Hamada M, Tanizaki Y

    J Jpn Assoc Phys Med Balneol Climatol   2004

  • Improvement of hyperinflation of the lungs by spa therapy in patients with asthma Reviewed

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Hamada M, Tanizaki Y

    J Jpn Assoc Phys Med Balneol Climatol   2004

  • Decreased computed tomographic lung density during exacerbation of asthma. Reviewed International journal

    Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Tanizaki Y

    The European respiratory journal   22 ( 1 )   106 - 12   2003.7

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    Recently, it was shown that both mean lung density (MLD) and the relative lung area with an attenuation of <-950 HU (RA950) are related to severity of asthma in nonsmoking asthmatics. The aim of the present study was to examine whether reduced computed tomography (CT) lung density during exacerbation could change after treatment. A cross-sectional study was performed to compare CT lung density in 30 stable asthmatics, 30 unstable asthmatics and 25 control subjects. In order to investigate longitudinally the effect of treatment on decreased CT lung density, 17 asthmatics with an exacerbation were followed at the initiation of treatment and 2 months after relief. The MLD was significantly lower and the RA950 significantly higher in unstable asthmatics than in controls and stable asthmatics. Both MLD and RA950 changed significantly with administration of systemic glucocorticoid therapy. The changes in forced expiratory volume in one second correlated significantly with those in both MLD and RA950. The changes in residual volume also correlated significantly with those in both MLD and RA950. It was concluded that decreased computed tomographic lung density during an asthma exacerbation is at least partially reversible, and changes in mean lung density and the relative lung area with a radiation attenuation of <-950 HU are related to the change in forced expiratory volume in one second and residual volume.

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  • Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma. Reviewed International journal

    Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y

    Journal of radiation research   44 ( 2 )   95 - 9   2003.6

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    An increased systemic production of oxygen-free radicals by activated inflammatory cells is thought to be involved in the pathophysiology of asthma. The aim of this study is to evaluate the clinical effects of radon and thermal therapy on asthma in relation to antioxidant enzymes and lipid peroxide. Radon and thermal therapy were performed once a week. All subjects went to a hot bathroom with a high concentration of radon, and nasal inhalation of vapor from a hot spring was performed for 40 min once a day under conditions of high humidity. The room temperature was 48 degrees C; the room radon concentration was 2,080 Bq/m3. Blood samples were collected at 2 h, 14, and 28 days after the first therapy. A blood sample also was collected before the first therapy (at body temperature and background radon level) to be used as the control. The forced expiratory volume in one second (%FEV1) was significantly increased 28 days after the first therapy. On day 28, the catalase (CAT) activity was significantly increased in comparison with the control. The superoxide dismutase (SOD) activity was significantly increased compared to the control after first inhalation. On days 14 and 28, the lipid peroxide level was significantly decreased in comparison with the control. In conclusion, the present pilot study has shown that radon and thermal therapy improved the pulmonary function of asthmatics by increasing the reduced activities of antioxidant enzymes.

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  • A proton-pump inhibitor, rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux. Reviewed International journal

    H Tsugeno, M Mizuno, S Fujiki, H Okada, M Okamoto, Y Hosaki, S Ashida, F Mitsunobu, Y Tanizaki, Y Shiratori

    Scandinavian journal of gastroenterology   38 ( 5 )   456 - 61   2003.5

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    BACKGROUND: Treatment of gastroesophageal reflux (GER) with proton-pump inhibitors (PPI) improves symptoms of asthma in some patients. However, the effects of a PPI on ventilatory function are still controversial. In this study, we measured ventilatory function in asthma patients treated with a PPI in order to identify those in whom a therapeutic effect on asthma can be expected from the acid suppression. METHODS: From a cohort of 114 consecutive patients with bronchial asthma, 53 patients agreed to participate in the study and were treated with rabeprazole 20mg daily for 8 weeks during an asymptomatic, stable period with no exacerbations of their asthma. Of the 53 patients, 22 were diagnosed as GER on the basis of the QUEST questionnaire and endoscopic examination. The patients were monitored for improvement in ventilatory function. RESULTS: Four patients dropped out because of adverse drug reactions. All the patients with GER noted an improvement in reflux symptoms with PPI treatment. An improvement of more than 20% in peak expiratory flow (PEF) was observed in 8 of 21 GER patients but in none of the non-GER patients. Factors predictive of improvement in PEF with rabeprazole therapy were the QUEST score (odds ratio: 1.47, 95% CI: 1.06-2.04, P = 0.022) and steroid-dependency of asthma (odds ratio: 0.01, 95% CI: 0.001-0.31, P = 0.008). CONCLUSIONS: Treatment with rabeprazole is expected to ameliorate asthma in non-steroid-dependent patients who have symptomatic GER defined by the QUEST score.

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  • Effects of Spa Therapy Combined with Dietary Supplementation with n-3 Fatty Acids on Bronchial Asthma.

    Okamoto M, Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

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  • [Physiopathology and treatment of bronchial asthma of the aged]. Reviewed

    Yoshiro Tanizaki, Fumihiro Mitsunobu, Yasuhiro Hozaki, Kozo Ashida

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   92 ( 3 )   448 - 52   2003.3

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  • Complexity of terminal airspace geometry assessed by computed tomography in asthma. Reviewed International journal

    Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida K, Takata S, Yokoi T, Mishima M, Tanizaki Y

    American journal of respiratory and critical care medicine   167 ( 3 )   411 - 7   2003.2

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    Low attenuation areas in computed tomography images from patients with chronic obstructive pulmonary disease have been reported to represent macroscopic and/or microscopic emphysema. The cumulative size distribution of the clusters has been shown to follow a power law characterized by the exponent D, a measure of the complexity of the terminal airspace geometry. We have previously found increased low attenuation areas in nonsmoking subjects with asthma. We examined the size distribution of the clusters in nonsmoking subjects with asthma compared with both nonsmoking control subjects and subjects with asthma with a smoking history. The percentage of lung field occupied by low attenuation areas (LAA%) and D in subjects with asthma with a smoking history differed significantly from nonsmoking subjects with asthma and control subjects. In nonsmoking subjects with asthma, both parameters differed significantly between severe asthma and mild or moderate asthma. The LAA% differed significantly between moderate and mild asthma, but D did not. In mild and moderate asthma, a highly significant correlation between LAA% and D was observed in patients with a smoking history, but not in nonsmoking subjects with asthma. Our results suggest that decreased D is mostly related to emphysematous change, and both measurements of LAA% and D may provide useful information to characterize low attenuation areas in subjects with asthma.

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  • Assessment of etidronic acid plus alfacalcidol for the treatment of osteopenia in steroid-dependent asthmatics - A pilot study of five cases Reviewed

    Tsugeno H, Nakai M, Okamoto M, Yokoi T, Takata S, Nishida N, Ashida K, Mitsunobu F, Yuki H,, Tanizaki Y, Shiratori Y

    CLINICAL DRUG INVESTIGATION   23 ( 2 )   99 - 105   2003

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    Objective: Osteoporosis is generally known to be one of the most serious adverse effects of long-term corticosteroid administration. Recently it was discovered that corticosteroid-induced osteoporosis occurs not only in trabecular bone but also in cortical bone, leading to a reduction in cortical bone strength. To ameliorate corticosteroid-induced bone injury, we administered etidronic acid plus alfacalcidol to five steroid-dependent asthmatics for 4 years and monitored therapeutic responses in trabecular bone and cortical bone using peripheral quantitative computed tomography (pQCT).
    Patients and interventions: The five steroid-dependent asthmatic patients included two males and three females, with a mean age 68.2 years, taking a mean daily dose of oral prednisolone of 7 mg/day. Etidronic acid 200 mg/day was administered for 14 consecutive days every 4 months for 4 years, while alfacalcidol 0.5 mug was administered daily for 4 years.
    Main outcome measures and results: Every 4 months, the number of vertebral fractures was assessed by lateral vertebral radiographs, and the total radial bone mineral density (BMD). trabecular BMD, cortical BMD, Relative Cortical Volume (RCV) and Strength Strain Index (SSI) were assessed by pQCT (Stratec XCT-960). At follow-up, no new fractures had occurred, the trabecular BMD was found to be slightly increased (from 117.2 mg/cm(3) at baseline to 121.6 mg/cm(3) after 48 months). and no significant decreases were observed in the total BMD, cortical BMD, RCV or SSI.
    Conclusion: Based on these findings, etidronic acid plus alfacalcidol seems to be effective in preventing steroid-induced bone injury, not only in terms of trabecular and cortical BMD, but also in terms of cortical bone volume and strength, which may lead to a decrease in non-vertebral fractures. However, further investigation is required with a larger sample size and a longer administration period to confirm these findings.

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  • Spa Therapy for Patients with Respiratory Disease Admitted at Misasa Medical Center for Last 20 Years. Reviewed

    Mitusnobu F, Hosaki Y, Ashida K, Nishida N, Tsugeno H, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003

  • Long-term Spa Therapy Prevents the Progressive Pathological Changes of the lung in Patients with Pulmonary Emphysema. Reviewed

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003

  • Decrease in Low Attenuation Area (LAA) of the Lungs on High Resolution Computed Tomography (HRCT) by Long-term Spa Therapy in Patients with Asthma. Reviewed

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003

  • Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis. Reviewed International journal

    Tsugeno H,, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA   13 ( 8 )   650 - 6   2002.8

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    Despite an intriguing understanding of trabecular bone dynamics, little is known about corticosteroid-induced cortical bone loss and fractures. Recently, we verified a steroid-induced decrease in cortical bone volume and density using peripheral quantitative computed tomography (pQCT) in adult asthmatic patients given oral corticosteroids. Subsequently, the pQCT parameters and presence of vertebral fractures were investigated to further clarify the role of cortical bone quality in fractures in 86 postmenopausal (>5 years after menopause) asthmatic patients on high-dose oral steroid (>10 g cumulative oral prednisolone) (steroid group) and 194 age-matched controls (control group). Cortical and trabecular bone was subjected to measurement of various parameters using pQCT (Stratec XCT960). Relative Cortical Volume (RCV) was calculated by dividing the cortical area by the total bone area. Strength Strain Index (SSI) was determined in the radius based on the density distribution around the axis. Spinal fracture was assessed on lateral radiographs. Patients treated with high doses of oral steroid (>10 g cumulative oral prednisolone) were found to have an increased risk of fracture compared with control women receiving no steroid medication (odds ratio, 8.85; 95% CI, 4.21-18.60) after adjustment was made for years since menopause, body mass index and RCV. In both groups, the diagnostic and predictive ability of the pQCT parameters for vertebral fracture was assessed by the areas under their receiver operating characteristic (ROC) curves. All parameters were found to be significant predictors ( p<0.0001) in the control group. In the steroid group, however, the cortical bone mineral density (BMD) ( p = 0.001), RCV ( p<0.0001) and SSI ( p = 0.001) were found to be significant predictors, but not trabecular BMD ( p = 0.176). For comparison between the two groups, thresholds of all parameters for vertebral fracture were also calculated by the point of coincidence of sensitivity with specificity in ROC testing and the 90th percentile value. Although a rise in fracture threshold in the steroid group was suggested, considerable difference in the values obtained by the two methods of calculation precluded any conclusion. High-dose oral steroid administration was associated with an increased risk of fracture. Cortical bone parameters obtained by pQCT could play a role as good predictors of future corticosteroid-induced vertebral fractures.

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  • The Effects of Spa Therapy on Asthma-Relationship of the generation of leukotrienes B4 (LTB4) and C4 (LTC4) and bronchial Hyperresponsiveness- Reviewed

    Ashida K, Mitsunobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Yokoi T, Takata S, Tanizaki Y

    J. Jpn Assoc Phys Med Baln Clim   2002

  • Influence of age and disease severity on high resolution CT lung densitometry in asthma. Reviewed International journal

    Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y

    Thorax   56 ( 11 )   851 - 6   2001.11

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    BACKGROUND: Low attenuation areas (LAA) on computed tomographic (CT) scans have been shown to represent emphysematous changes in patients with chronic obstructive pulmonary disease (COPD). However, the significance of LAA is still controversial in patients with asthma. This study was undertaken to assess the usefulness of lung CT densitometry in the detection of airspace enlargement in association with asthma severity. METHODS: Forty five asthmatic subjects and 15 non-smoking controls were studied to determine the influence of age, pulmonary function, and asthma severity on mean lung density (MLD) and the relative area of the lung showing attenuation values less than -950 HU (RA(950)) on high resolution CT (HRCT) scans. RESULTS: In asthmatic patients both MLD and RA(950) correlated with parameters of airflow limitation (%FEV(1), FEV(1)/FVC, %FEF(25-75)) and lung volume (%TLC, %FRC, %RV), but not with lung transfer factor (%TLCO, %TLCO/VA). The results of HRCT lung densitometry also correlated with patient age and severity of asthma. CONCLUSIONS: Decreased CT lung density in non-smoking asthmatics is related to airflow limitation, hyperinflation and aging, but not with lung transfer factor.

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  • Low-attenuation areas of the lungs on high-resolution computed tomography in asthma. Reviewed International journal

    Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Tanizaki Y

    The Journal of asthma : official journal of the Association for the Care of Asthma   38 ( 5 )   413 - 22   2001.8

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    To investigate the low-attenuation areas of the lungs (LAA) in asthma, we compared the mean lung density (MLD) and the LAA in 22 asthmatics (12 ex-smokers and 10 nonsmokers) and 13 patients with chronic obstructive pulmonary disease (COPD) by high-resolution computed tomography. The MLD and the relative area of the lung with attenuation values lower than -950 Hounsfield Units at full inspiration (inspiratory RA950) were significantly different in nonsmoking asthmatics compared to patients with COPD and asthmatics with a smoking history. The MLD and the RA950 correlated significantly with the FEV1 in all groups and with the DL(CO) in patients with COPD and asthmatics with a smoking history but not in nonsmoking asthmatics. We concluded that the LAA in asthmatics with a smoking history indicates the presence of emphysema, but in nonsmoking asthmatics it reflects hyperinflation and nonemphysematous expiratory airflow limitation rather than emphysematous lesions.

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  • Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies in patients with chronic obstructive pulmonary disease. Reviewed International journal

    Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Takata S, Tanizaki Y

    The Journal of allergy and clinical immunology   107 ( 3 )   492 - 8   2001.3

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    BACKGROUND: How leukotrienes (LTs) and IgE-mediated allergy reflect clinical features in patients with chronic obstructive pulmonary disease (COPD) remains unclear. OBJECTIVE: Our goal was to determine whether LTB4 and LTC4 would correlate with airway obstruction and whether IgE-mediated allergy would influence the generation of LTs and bronchial hyperresponsiveness in patients with COPD. METHODS: We measured the pulmonary function, methacholine bronchial hyperresponsiveness, and generation of LTB4 and LTC4 from peripheral leukocytes stimulated with calcium ionophore A23187 in relation to the presence of specific IgE antibodies against inhalant allergens. RESULTS: The leukocytes of patients with COPD generated significantly more LTB4 (with allergy, P <.001; without allergy, P <.001) and LTC4 (with allergy, P <.001; without allergy, P <.01) than the leukocytes of the control subjects. LTC4 production was significantly higher in the allergic COPD subjects than in the nonallergic COPD patients (P <.01), but the amount of LTB4 generated was not significantly different. FEV(1) significantly correlated with the level of both LTB4 (with allergy, r = -0.556, P =.0375; without allergy, r = -0.731, P =.0046) and LTC4 (with allergy, r = -0.764, P =.0043; without allergy, r = -0.526, P =.0414) generation in COPD. The log(10) of the minimum dose of methacholine was significantly higher in COPD patients without allergy than in those with allergy (P <.05). CONCLUSION: Enhanced LT generation from peripheral leukocytes is observed in patients with COPD, and the presence of specific IgE antibodies against inhalant allergens enhances LTC4 generation, bronchial hyperresponsiveness, and the relationship between LTC4 generation and airway obstruction.

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  • A patient with severe palindromic rheumatism and frequent episodes of pain. Reviewed

    Takata S, Harada S, Mitsunobu F, Mifune T, Hosaki Y, Asida K, Tsugeno H, Okamoto M, Iwahashi M, Kawashima M, Yamamura M, Makino H, Tanizaki Y

    Internal medicine (Tokyo, Japan)   40 ( 2 )   140 - 3   2001.2

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    A 44-year-old man began to experience episodes of joint pain with erythema in his knees, elbows, shoulders, and hands in April 1996. He was diagnosed as having palindromic rheumatism. Due to the increasing frequency and severity of these episodes, he was admitted to our hospital in May 1999. Heat therapy to the affected area produced a rapid improvement in symptoms. In addition, the continued use of physical therapy during symptom-free periods tended to reduce the frequency and severity of pain attacks. We present this case and discuss treatment options in patients with palindromic rheumatism.

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  • 気管支喘息および肺気腫に対する温泉療法.;最近9年間(1992年-2000年)の入院症例1271例の解析ー Reviewed

    光延文裕, 御舩尚志, 保崎泰弘, 芦田耕三, 柘野浩史, 岡本 誠, 西田典数, 横井 正, 高田真吾, 谷崎勝朗, 越智浩二

    日温気物医誌   63:65-72   2001

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  • Effect of spa therapy on low attenuation area (LAA) of the lungs on high-resolution computed tomography (HRCT) and pulmonary function in patients with asthma. Reviewed

    Ashida K, Mitsunobu F, Mifune T, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Yokoi T, Takata S, Tanizaki Y

    J. Jpn Assoc Phys Med Baln Clim   2001

  • Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients. Reviewed International journal

    H Tsugeno, B Goto, T Fujita, M Okamoto, T Mifune, F Mitsunobu, K Ashida, Y Hosaki, T Tsuji, Y Tanizaki

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA   12 ( 4 )   266 - 70   2001

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    Despite a deepening understanding of the influence of glucocorticoids (GC) on trabecular bone, little is known about GC-induced cortical bone loss. To elucidate the mechanism of GC-induced loss of cortical bone strength with particular reference to cortical bone loss, changes in cortical density, relative cortical volume, and the Strength Strain Index (SSI) based on biomechanical analyses of the geographic distribution of cortical bone material were measured. These parameters were compared, using peripheral quantitative computed tomography (pQCT), among the following age-matched groups: 68 postmenopausal asthmatic patients receiving high-dose oral GC in addition to inhaled GC (oral GC group), 68 postmenopausal asthmatic patients receiving only inhaled GC (inhaled GC group) and 69 postmenopausal controls without asthma or GC therapy (control group). Cortical bone mineral density (BMD) was measured, relative cortical volume was obtained by dividing the cortical area by the total bone area using pQCT (Stratec XCT960), and the Strength Strain Index (SSI) was calculated in the radius based on the density distribution around the axis. Spinal fracture was assessed on lateral radiographs. The number of vertebral fractures per patient correlated highly with cortical BMD, relative cortical volume and SSI values at the radius. The number of vertebral fractures per patient and the number of patients with fracture were similar between the control and inhaled GC group, both being significantly lower than those in the oral GC group. Total BMD, trabecular BMD, cortical BMD, relative cortical volume and SSI were similar between the first two, being significantly higher than in the last group. The slopes of cortical volume-density relationship, however, were identical among the three groups, indicating the persistence of cortical bone remodeling and a similar degree of calcification regardless of GC administration.

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  • Correlation between efficacy of spa therapy and bronchial hyperresponsiveness in elderly patients with asthma. Reviewed

    Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Ochi K, Tanizaki Y

    Jpn Assoc Phys Med Baln Clim   2001

  • Basic study on radon effects and thermal effects on humans in radon therapy. Reviewed International journal

    Yamaoka K, Mifune T,, Mitsunobu F, Kojima S, Mori S, Shibuya K, Tanizaki Y, Sugita K

    Physiological chemistry and physics and medical NMR   33 ( 2 )   133 - 8   2001

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    Because most of the diseases to which radon (222Rn) therapy is applied are related to activated oxygen, in this study the effect of the radioactivity of radon and the thermal effect were compared under a room or a hot spring condition with the same chemical component using as the parameters the activity of superoxide dismutase (SOD), which is an oxidation inhibitor, and lipid peroxide and low density lipoprotein (LDL)-cholesterol, which are closely involved in arteriosclerosis. Results show that the SOD activity was significantly increased, and the lipid peroxide and LDL-cholesterol levels were significantly decreased on days 6 and 7 of study. The results were about 2-fold larger in the radon group than in the thermo group. This suggests that the anti-oxidation function was more enhanced by radon therapy than by thermo therapy, and suggests that radon therapy may help to prevent the causes of life style-related diseases such as arteriosclerosis. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.

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  • Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. Reviewed International journal

    F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, M Okamoto, S Harada, S Takata, Y Tanizaki, M Harada

    The European respiratory journal   16 ( 3 )   504 - 8   2000.9

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    Leukotrienes (LTs) are pro-inflammatory mediators that contribute to the pathophysiological features of asthma. The relationship between the amounts of LTB4 and LTC4 produced by the leukocytes of asthmatic patients on the one hand and immunoglobulin E (IgE)-mediated allergy, asthma exacerbations and bronchial hyperresponsiveness was studied. Leukocytes were obtained from peripheral blood drawn from 29 atopic and 27 nonatopic asthmatics during exacerbations and clinically controlled periods, as well as from 20 control individuals. The leukocytes were stimulated with calcium ionophore A23187 to induce LTB4 and LTC4 production. Allergy was assessed by means of specific serum IgE or by positive skin tests, whereas bronchial hyperresponsiveness was measured by methacholine challenge. The leukocytes of the asthmatics generated significantly more LTB4 (p<0.05) and LTC4 (p<0.01) than those of controls. The leukocytes of patients with atopic asthma generated significantly more LTC4 than those of patients with nonatopic asthma (p<0.01). Significantly more LTC4 was produced by leukocytes obtained during exacerbations, than by those obtained during clinically controlled periods (p<0.01). In addition, there was a significant correlation between LTB4 generation by leukocytes and the degree of bronchial hyperresponsiveness to methacholine (r=-0.792, p<0.0001). These results suggest that leukotriene C4 production by leukocytes is associated with immunoglobulin E-mediated allergy and asthma exacerbations, and further that generation of leukotriene B4 is closely related to bronchial hyperresponsiveness in patients with asthma.

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  • Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Reviewed International journal

    M Okamoto, F Mitsunobu, K Ashida, T Mifune, Y Hosaki, H Tsugeno, S Harada, Y Tanizaki, M Kataoka, K Niiya, M Harada

    International archives of allergy and immunology   122 ( 2 )   137 - 42   2000.6

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    BACKGROUND: Dietary sources of alpha-linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with asthma, as has been reported with the consumption of other long-chain n-3 fatty acids. METHODS: The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n-3 fatty acids). Group A consisted of patients in whom the leucocyte generation of LTC4 was suppressed by dietary perilla seed oil. Group B consisted of those in whom LTC4 generation was not suppressed. RESULTS: LTC4 generation by leucocytes decreased significantly in group A after 2 (p < 0.05) and 4 weeks (p < 0.05); conversely, it increased significantly in group B after 4 weeks (p < 0.05). The two study groups differed significantly in terms of LTC4 generation by leucocytes after 4 weeks of dietary supplementation (p < 0.05). Ventilatory parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05). Values of PEF, FVC, FEV(1) and maximum expiratory flow at 25% of the forced vital capacity (V(25)) differed significantly between groups A and B prior to dietary supplementation. Serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks. Serum levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL cholesterol and phospholipid differed significantly between the two study groups prior to dietary supplementation. Serum levels of triglyceride and LDL cholesterol differed significantly between the two study groups after 4 weeks of dietary supplementation. CONCLUSIONS: Dietary supplementation with perilla seed oil in selected patients with asthma suppresses the generation of LTC4 and is associated with clinical features such as respiratory function and lipometabolism.

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  • [Current topics on inhalation therapy for obstructive pulmonary diseases]. Reviewed

    F Mitsunobu, T Mifune, Y Tanizaki

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   89 ( 5 )   995 - 1002   2000.5

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  • IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. relationship to family history of the disease. Reviewed International journal

    F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, M Okamoto, S Harada, Y Tanizaki

    Age and ageing   29 ( 3 )   215 - 20   2000.5

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    OBJECTIVE: to uncover any differences in the age-related and IgE-mediated pathophysiology of the airways in asthmatics. METHODS: we examined the relationship of both IgE-mediated bronchial hyperresponsiveness and the cell content of bronchoalveolar lavage fluid with a family history of asthma in 263 patients with asthma classified according to age at onset. RESULTS: bronchial hyperresponsiveness decreased significantly as age at onset increased in those without a family history. Responsiveness was significantly higher in patients who were > or = 60 years of age at onset who had a family history than in those who did not (P < 0.05). The proportion of lymphocytes in bronchoalveolar lavage fluid was significantly higher in patients between 50 and 59 years old at onset who had a family history than those who did not (P < 0.05). These results suggest that bronchial hyperresponsiveness and the proportion of bronchoalveolar lavage lymphocytes differ according to the presence or absence of a family history, a finding which is closely related to IgE-mediated allergy in elderly patients at onset. CONCLUSIONS: our findings suggest (i) the possibility of asthma induced by non-IgE-mediated allergy in elderly patients and (ii) that bronchial responsiveness is also influenced by IgE-mediated allergy and age at onset.

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  • Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. Reviewed

    M Okamoto, F Mitsunobu, K Ashida, T Mifune, Y Hosaki, H Tsugeno, S Harada, Y Tanizaki

    Internal medicine (Tokyo, Japan)   39 ( 2 )   107 - 11   2000.2

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    OBJECTIVE: The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. METHODS AND SUBJECTS: 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. RESULTS: The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV(1.0) (p<0.05) and V(25) (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV(1.0) (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation. CONCLUSION: These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.

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  • Glucocorticoid-induced cortical bone porosity in postmenopausal patients with asthma Reviewed

    H Tsugeno, B Goto, M Okamoto, S Harada, T Mifune, Y Hosaki, F Mitsunobu, K Ashida, Y Tanizaki

    OSTEOPOROSIS INTERNATIONAL   11   S131 - S131   2000

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  • Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography. Reviewed International journal

    H Tsugeno, M Nakai, M Okamoto, S Harada, T Mifune, F Mitsunobu, K Ashida, Y Hosaki, Y Tanizaki, T Tsuji

    The European respiratory journal   14 ( 4 )   923 - 7   1999.10

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    Chronic use of systemic glucocorticoids results in progressive bone loss and pathologic fractures. This study identified the predictive variables for bone loss and used peripheral quantitative computed tomography (pQCT) to measure changes in cortical and trabecular bone in patients receiving systemic glucocorticoid therapy of prednisone 15.4 g. Eighty-four asthmatic patients were included in the study. Vertebral fractures were diagnosed via plain spinal radiograms. pQCT was used to measure cortical and trabecular bone mineral density. Multiple regression analysis identified variables with predictive value. The cumulative dose of glucocorticoid correlated with the bone mineral density (p<0.05) and the trabecular bone density (p<0.01). Among patients > or = 65 yrs of age, the cumulative dose of glucocorticoid correlated with the occurrence of vertebral fractures (p<0.05), total bone mineral density (p<0.01) and cortical bone mineral density (p<0.01). Bone mineral density in the distal radius measured by pQCT and the vertebral bodies by axis QCT were correlated, regardless of whether systemic glucocorticoids were administered. Glucocorticoid administration not only decreases trabecular but also cortical bone mineral density. Since cortical bone provides strength and stiffness, it appears that the loss of cortical bone is responsible for the increased incidence of fracture seen in patients receiving systemic glucocorticoid therapy.

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  • Giant cell arteritis associated with rheumatoid arthritis monitored by magnetic resonance angiography. Reviewed

    S Harada, F Mitsunobu, F Kodama, Y Hosaki, T Mifune, H Tsugeno, M Okamoto, M Yamamura, H Makino, Y Tanizaki

    Internal medicine (Tokyo, Japan)   38 ( 8 )   675 - 8   1999.8

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    A 57-year-old Japanese woman with well controlled rheumatoid arthritis visited our hospital with a severe bitemporal headache and marked fatigue. Based on the classification criteria by the American College of Rheumatology, she was diagnosed as having giant cell arteritis. Magnetic resonance (MR) angiography was performed, from which stenotic changes in the bilateral superficial temporal arteries were strongly suspected. Corticosteroid therapy was quickly started. The patient followed an uneventful course with no complications. Therapeutic effect was confirmed by MR angiographic findings obtained 4 weeks after the initiation of therapy.

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  • [Age-related changes of IgE-mediated allergic reaction in patients with late onset asthma--relationship between IgE-mediated allergy and age at onset]. Reviewed

    S Yokota, F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, Y Tanizaki

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   35 ( 5 )   367 - 73   1998.5

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    We examined age-related changes in the IgE-mediated allergic reaction in patients with late onset asthma, whose asthma first occurred at over 40 years. 1. The number of patients with a high serum IgE level (over 300 IU/ml) was larger in patients with an age of onset between 40 and (40-49 years group) and in patients older than 60 at age of onset (60-year group) than in patients with an age of onset between 50 and 59 (50-59 year group). 2. A positive RAST score to house dust mite (HDm) allergen was more frequently found in the 40-49 year group and in the 60- year group than in the 50-59 year group. Frequency of positive RAST score to HDm in the 50-59 year group was significantly lower (p < 0.01) than in early-onset asthma patients (age at onset less than 39 years). 3 Frequency of family history of asthma in the 50-59 years group was high, being equal to that of early-onset asthma patients. 4 In the 50-59 year group, the frequency of severe asthma was comparatively higher than that of the other groups. The frequency of IgE-mediated allergic reaction changed in regard to age of onset of asthma, and allergic reactions in late-onset asthma partially resembled those of early-onset asthma. These results suggest that an atopic constitution is related to the onset of bronchial asthma in the elderly.

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  • Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. Reviewed International journal

    F Mitsunobu, T Mifune, Y Hosaki, K Ashida, S Yokota, H Tsugeno, Y Tanizaki

    The Journal of asthma : official journal of the Association for the Care of Asthma   35 ( 4 )   367 - 72   1998

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    The release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells and peripheral blood stimulated with Ca ionophore A23187 was compared between atopic and nonatopic asthma. The proportion of basophilic cells in BAL fluid was significantly higher in atopic than in nonatopic asthma (p < 0.01); however, no significant differences were present in the other BAL cells between the two asthma types. The concentration of histamine in BAL fluid was significantly higher in younger patients (20-59 years) with atopic than in nonatopic asthma (p < 0.01). In contrast, the concentration of LTC4 was significantly higher in nonatopic than in younger patients with atopic asthma (p < 0.01). The release of histamine from BAL cells (p < 0.001) and peripheral blood (p < 0.01) was significantly larger in younger patients with atopic than in nonatopic asthma. The generation of LTC4 by BAL cells was significantly larger in nonatopic than in younger (p < 0.01) and older patients with atopic asthma (60+ years) (p < 0.05). These results suggest that both histamine and LTC4 participate in the onset mechanism of atopic asthma, and only LTC4 participates in that of nonatopic asthma.

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  • [Psychological investigation on spa therapy in patients with bronchial asthma]. Reviewed

    S Yokota, T Mifune, F Mitsunobu, Y Hosaki, K Ashida, H Tsugeno, Y Tanizaki, K Saitou, S Tada, M Harada

    Arerugi = [Allergy]   46 ( 6 )   511 - 9   1997.6

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    To evaluate the effects of complex spa therapy (swimming training in a hot spring pool + fango therapy + inhalation of iodine salt solution) on psychological factors, three psychological examinations; CMI (Cornell Medical Index), SDS (Self-Rating Depression Scale) and CAI (Comprehensive Asthma Inventory); were given 25 patients with bronchial asthma (10 male, 15 female, mean age 60 years), and the results of these examinations were compared before and after spa therapy. 1. Physical symptoms, respiratory system and CIJ symptoms by CMI were significantly improved after spa therapy, however the improvement of psychical symptoms was not significant. 2. In SDS, 11 of 25 patients showed more than 40 points, indicating depressive state. The number of such patients decreased from 11 to 2 and the mean SDS score significantly improved from 38.7 to 34.2 after spa therapy. 3. Conditioning, suggestion, fear of expectation, frustration, flight into illness, negative attitudes towards prognosis, and decreased motivation towards therapy by CAI were significantly reduced after spa therapy, with the reduction in negative attitudes towards prognosis and decreased motivation towards therapy being relatively large. Furthermore, CAI score, which is the average of the categories in CAI, was also significantly decreased from 37.9 to 28.4 after spa therapy. These results suggested that complex spa therapy improves psychological factors in patients with bronchial asthma.

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  • A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma Reviewed

    Kozo Ashida, Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki, Takao Tsuji

    Allergology International   46 ( 3 )   181 - 185   1997

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    N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P &lt
    0.05). The generation of leukotriene B4(LTB4) by peripheral leukocytes stimulated with the Ca2+ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X106cells by dietary supplementation (P&lt
    0.05). The generation of leukotriene C4(LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106cells after supplementation with perilla seed oil (P &lt
    0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma. © 1997, Japanese Society of Allergology. All rights reserved.

    DOI: 10.2332/allergolint.46.181

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  • IgE-mediated allergy in elderly patients with asthma

    Mitsunobu Fumihiro, Mifune Takashi, Hosaki Yasuhiro, Ashida Kouzou, Tsugeno Hirofumi, Yokota Satoshi, Tanizaki Yoshiro, Tada Shinya, Harada Mine

    Allergol. Int.   46 ( 4 )   237 - 241   1997

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    The incidence of a positive family history with asthma and levels of serum IgE and IgE antibodies were examined in 136 patients with asthma in relation to age at onset of the disease. The frequency of subjects with a family history of asthma ranged from 37.9 to 75.0% in all groups classified by age at onset. The frequency of patients with a high serum IgE level (≥150IU/mL) was higher (51.7-63.2%) in all groups than the frequency of patients with a low serum level (<150IU/mL). The mean level of serum IgE was significantly higher in patients with a family history than in those without a family history, in subjects between the ages of 50 and 59 years at onset (mean age 63.4 years; P<0.02) and in those over the age of 60 years at onset (74.0 years; P<0.01). The number of patients with a positive RAST score either to house dust mite (HDM), cockroach, and Candida tended to decrease as the age at onset increased. However, the frequency of positive RAST to HDM was higher in patients with a family history and who were over the age of 50 years at onset compared with those patients between the ages of 40 and 49 years at onset, although the frequency was significantly higher in patients with family history than in those without family history (P<0.02). These results suggest that IgE-mediated allergic reactions are significant not only in those patients who are younger, but also in elderly patients with asthma.

    DOI: 10.2332/allergolint.46.237

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  • Reduction of Glucocorticoids by Spa Therapy in Patients with Steroid-Dependent Intractable Asthma(SDIA).

    HOSAKI Yasuhiro, MIFUNE Takashi, MITSUNOBU Fumihiro, YOKOTA Satoshi, TANIZAKI Yoshiro, OCHI Koji, HARADA Hideo, IKEDA Satoru, TAKETA Kazuhisa

    The Journal of Japanese Balneo-Climatological Association   59 ( 4 )   201 - 208   1996

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    DOI: 10.11390/onki1962.59.201

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  • Action Mechanisms of Spa Therapy on Pathophysiological Changes of Airways in Patients with Asthma. Comparison between effective and noneffective cases with simple bronchoconstriction type.:Comparison between effective and noneffective cases with simple bronchoconstriction type

    YOKOTA Satoshi, MIFUNE Takashi, MITSUNOBU Fumihiro, HOSAKI Yasuhiro, TANIZAKI Yoshiro, OCHI Koji, HARADA Hideo, IKEDA Satoru, TAKETA Kazuhisa

    The Journal of Japanese Balneo-Climatological Association   59 ( 4 )   243 - 250   1996

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    DOI: 10.11390/onki1962.59.243

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  • Action Mechanisms of Spa Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD).

    TANIZAKI Yoshiro, KITANI Hikaru, MIFUNE Takashi, MITSUNOBU Fumihiro

    The Journal of Japanese Balneo-Climatological Association   57 ( 3 )   183 - 190   1994

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    DOI: 10.11390/onki1962.57.183

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  • Ten-year Study on Spa Therapy in 329 Patients with Bronchial Asthma.

    TANIZAKI Yoshiro, KITANI Hikaru, MIFUNE Takashi, MITSUNOBU Fumihiro, OCHI Koji, HARADA Hideo, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   57 ( 2 )   142 - 150   1994

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    DOI: 10.11390/onki1962.57.142

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  • Distant Effect of Spa Therapy on Bronchial Asthma in Relation to Cellular Composition of the Airways and Ventilatory Function.

    TANIZAKI Yoshiro, KITANI Hikaru, MIFUNE Takashi, MITSUNOBU Fumihiro, KAJIMOTO Kazuhiro, OCHI Koji, HARADA Hideo, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   57 ( 3 )   199 - 208   1994

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    DOI: 10.11390/onki1962.57.199

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  • IgE-mediated allergic reaction in drug-induced asthma. Reviewed

    H Kitani, K Kajimoto, K Sugimoto, T Mifune, F Mitsunobu, S Yokota, J Hiramatsu, M Kawaraya, Y Tanizaki

    Acta medica Okayama   47 ( 5 )   317 - 21   1993.10

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    Immunoallergological studies were carried out to clarify the differences between 24 patients with drug-induced asthma (DIA) and 240 with non-drug-induced asthma (non-DIA). The mean values of age, skin reaction to Candida albicans (C. albicans), serum IgE levels, specific IgE antibodies to house dust (HD) and C. albicans, bronchial sensitivity and leukotriene B4 (LTB4) synthesis from peripheral venous blood in patients with DIA were not significantly different from those in patients with non-DIA. In contrast, the frequency of positive skin reaction to HD and histamine release from peripheral basophils by anti-IgE were significantly lower in DIA than in non-DIA. These results agree with the reports that DIA was often observed in non-atopic asthma. But, the mean value of serum IgE was very high in DIA as well as in non-DIA. This result suggests that IgE mediated reaction in DIA is important. Furthermore, the proportion of neutrophils in bronchoalveolar lavage fluid (BALF) was significantly lower in DIA than in non-DIA. Our findings suggest that a decrease of intrapulmonary neutrophils might play an important role in the pathophysiology of DIA.

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  • Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA). Reviewed

    T Mifune, Y Tanizaki, H Kitani, M Okazaki, F Mitsunobu, K Kajimoto, I Kimura

    Acta medica Okayama   47 ( 5 )   323 - 8   1993.10

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    The effects of long-term glucocorticoid therapy on chemical mediator and cellular reaction in the airways were examined in 69 patients with bronchial asthma. The histamine release induced by Ca ionophore A23187 from cells in the bronchoalveolar lavage (BAL) fluid of atopic asthmatics was significantly lower in the subgroup with steroid-dependent intractable asthma (SDIA) than in non-SDIA patients (p < 0.05). In contrast, histamine release in nonatopic SDIA patients did not differ from nonatopic non-SDIA patients. The release of leukotriene C4 (LTC4) was significantly lower in atopic patients with SDIA (p < 0.02). However, there was no significant difference in LTC4 release between nonatopic patients with SDIA and without SDIA. The proportion of BAL lymphocytes was significantly lower in atopic patients with SDIA than in those without it (p < 0.05), although there was no significant difference between the nonatopic patients with and without SDIA. These results show that glucocorticoids affect humoral and cellular events in the airways of atopic asthmatics more than in those of nonatopic asthmatics.

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  • Cell-mediated immunity in bronchial asthma evaluated by purified protein derivative- and Candida albicans-skin reaction. Reviewed

    F Mitsunobu, H Kitani, M Okazaki, T Mifune, T Okano, N Honke, Y Tanizaki

    Acta medica Okayama   47 ( 4 )   229 - 32   1993.8

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    Cell-mediated immunity was examined in 45 patients with bronchial asthma by observing the delayed cutaneous reaction to purified protein derivative (PPD) and Candida albicans (C. albicans). The delayed skin reaction to PPD showed a decrease with age starting between 50 and 59 years old. The delayed reaction to PPD decreased more prominently with aging, being significantly depressed in the patients aged over 70 years than in those aged between 30 and 49 years (induration, p < 0.02; flare, p < 0.01). The C. albicans-induced skin reaction was significantly lower in the patients aged over 70 years than in those between 60 and 69 years old (induration, p < 0.01; flare, p < 0.05). The delayed skin reaction to PPD and C. albicans was significantly depressed in the patients with a serum IgE level over 1001 IU/ml. Delayed skin reaction to PPD and C. albicans was more depressed with aging and an elevated serum IgE, and the age (50-59 years) at the initiation of depression in the PPD-induced delayed skin reaction was younger than that (over 70 years) in the C. albicans-induced reaction.

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  • [Changes in bronchoalveolar cell profiles of asthma patients induced by long-term glucocorticoid therapy]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, R Soda, T Kiyoshi, K Takahashi, I Kimura

    Nihon Kyobu Shikkan Gakkai zasshi   31 ( 6 )   717 - 24   1993.6

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    Effects of long-term glucocorticoid therapy on airway inflammatory cells were examined in 40 patients with bronchial asthma. 1. The dose of glucocorticoids required by asthmatic patients tended to increase and the level of serum cortisol tended to decrease with prolongation of the period of glucocorticoid therapy. 2. The proportion and number of lymphocytes in bronchoalveolar lavage (BAL) fluid decreased with prolongation of the period of glucocorticoid therapy. The proportion of BAL lymphocytes in asthmatic patients treated with glucocorticoids for more than 5 years was significantly lower than that in those treated for less than 4.9 years. 3. The proportion and number of BAL neutrophils increased with prolongation of the period of glucocorticoid therapy and the proportion of BAL neutrophils in patients treated with glucocorticoids for more than 10 years was significantly higher compared with those treated for less than 9.9 years. These findings indicate that long-term glucocorticoid therapy induces changes in airway inflammatory cell profiles, with a decrease in the number of lymphocytes and increase in the number of neutrophils.

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  • [Clinical features of bronchial asthma with mucus hypersecretion]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, R Soda, S Tada, K Takahashi, I Kimura

    Nihon Kyobu Shikkan Gakkai zasshi   31 ( 5 )   575 - 9   1993.5

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    Fifty patients with bronchial asthma were divided into four groups according to the amount of expectoration per day: 0-24, 25-49, 50-99 and 100+ ml/day. Clinical features of patients with mucus hypersecretion (more than 50 ml/day of expectoration) were evaluated by age, severity of disease, cellular composition of bronchoalveolar lavage (BAL) fluid, and ventilatory function. 1. The proportion of patients with steroid-dependent intractable asthma (SDIA) in each group increased with increase in mucus hypersecretion. 2. Many of the patients with mucus hypersecretion (more than 50 ml/day) were over the age of 40. 3. The proportion of BAL eosinophils was significantly higher in patients with hypersecretion (more than 50 ml/day) than in those with expectoration of less than 49 ml/day. There was a significant correlation between the proportion of BAL eosinophils and the amount of expectoration per day (r = 0.48, p < 0.05). Proportions of lymphocytes and neutrophils in the BAL fluid were not related to the amount of expectoration per day. 4. There was no significant correlation between the amount of expectoration per day and ventilatory function in patients with asthma in this study.

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  • [Correlation between proportion of BAL cells and ventilatory function in patients with asthma]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, R Soda, S Tada, K Takahashi, I Kimura

    Nihon Kyobu Shikkan Gakkai zasshi   31 ( 4 )   459 - 64   1993.4

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    The correlation between proportions of cells in bronchoalveolar lavage (BAL) fluid and ventilatory function was examined in 52 patients with asthma. 1. There was no significant correlation between the proportion of BAL lymphocytes and ventilatory function. 2. The proportion of BAL eosinophils correlated to a certain extent with ventilatory function: the values of %MMF, %V50 and %V25 were lower in patients with BAL eosinophils of 10-19.9% than in those with BAL eosinophils below 4.9%, and %V25 value was significantly lower in patients with a high proportion of BAL eosinophils (10-19.9%) compared with those with a low proportion of BAL eosinophils (0-4.9%). However, ventilatory function was not decreased in patients with BAL eosinophils of more than 20%. 3. The values of ventilatory parameters showed a tendency to decrease with increase in BAL neutrophils. The values of all parameters of obstructive ventilatory dysfunction were significantly lower in patients with BAL neutrophils of > 10% than in those with BAL neutrophils < 4.9%. A significant difference between patients with BAL neutrophils > 10% and < 9.9% was found in values of %V50 and %V25, and the values of %V50 and %V25 were significantly lower in patients with a high proportion of BAL neutrophils (> 10%) than in those with BAL neutrophils < 9.9%. These results suggest that the proportion of BAL eosinophils is to a certain extent related to ventilatory function of asthma patients and that the increase in proportion of BAL neutrophils is closely related to a decrease in values of obstructive ventilatory parameters.

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  • Clinical effects of complex spa therapy on patients with steroid-dependent intractable asthma (SDIA). Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, N Honke

    Arerugi = [Allergy]   42 ( 3 Pt 1 )   219 - 27   1993.3

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    The clinical effects of spa therapy (swimming training in a hot spring pool+inhalation of iodine salt solution+fango therapy) were examined in 52 patients with steroid-dependent intractable asthma (SDIA). Clinical effects were found in 36 of the 52 (69.2%) patients with SDIA. The efficacy was higher in the patients between the ages of 41 and 50 (87.5%) and between 51 and 60 (84.2%) than in those in the other age groups. Regarding clinical asthma types, the efficacy of spa therapy was higher in patients with type Ia-2 (83.4%), type Ib (77.8%) and type II (80.0%) than in those with type Ia-1 (54.2%). Efficacy seemed to be related to airway inflammation: the proportion of neutrophils and eosinophils in bronchoalveolar lavage (BAL) fluid was higher in patients with marked and moderate improvement compared with those with slight and no improvement. Ventilatory function was improved by complex spa therapy. %MMF and %V25 values increased by more than 20% after therapy in patients with type Ia-2, Ib and II asthma. Bronchial hyperreactivity to methacholine was suppressed after therapy. Any decreased function of the adrenocortical glands expressed by low serum cortisol levels improved after therapy, accompanied by a reduction in the dose of glucocorticoids necessary to control asthma attacks.

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  • A new modified classification of bronchial asthma based on clinical symptoms. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, T Okano, N Honke, I Kimura

    Internal medicine (Tokyo, Japan)   32 ( 3 )   197 - 203   1993.3

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    The clinical features of four asthma types, Ia-1 (bronchospasm with 0-49 ml/day of expectoration), Ia-2 (with 50-99 ml/day), Ib (over 100 ml/day), and II (bronchiolar obstruction), as classified by the clinical symptoms, were compared in 119 patients with bronchial asthma. The age of onset characteristic symptoms of each asthma type was in the 20's in types Ia-1 and Ia-2, in the 30's in type Ib, and in the 40's in type II patients. A significant increase in the number of neutrophils in bronchoalveolar lavage (BAL) fluid was found in type II patients. The proportion of BAL eosinophils was significantly higher in types Ia-2 and Ib asthma patients compared with that in type Ia-1 patients. The BAL eosinophil count was significantly higher in type Ib than in type Ia-2 patients. The FEV1.0% and %V25 values were significantly lower in patients with type II asthma than in the patients with the other asthma types. Steroid-dependent intractable asthma (SDIA) was more often observed in patients with type Ib or type II asthma.

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  • Characteristics of airway responses in patients with bronchial asthma. Evaluation of asthma classification systems based on clinical symptoms and clinical findings. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, N Honke, I Kimura

    Arerugi = [Allergy]   42 ( 2 )   123 - 30   1993.2

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    Asthma was classified into three types according to clinical symptoms (clinical diagnosis, C.D.): Ia. simple bronchoconstriction type (further divided into two subtypes, type Ia-1 with 0-49 ml/day of expectoration and type 1a-2 with 50-99 ml/day); Ib. bronchoconstriction + hypersecretion type, and II. bronchiolar obstruction type. Asthma was also classified by a score related to clinical findings and examinations (score diagnosis, S.D.). The clinical features of each type of asthma according to the two classifications methods were compared. Type 1a-2 and 1b patients (C.D.) were characterized by mucus hypersecretion (more than 50 ml/day) and eosinophilia in the bronchoalveolar lavage (BAL) fluid. The characteristic findings for type II asthmatics (C.D.) were a lower %V25 value (less than 10%) and an increased proportion of neutrophils (more than 20%) in the BAL fluid. All of the patients classified as types 1a-1, Ib, and II by clinical diagnosis were evaluated as having the same types of asthma by score diagnosis. Patients with type Ia-2 evaluated by clinical diagnosis were classified as type Ib by score diagnosis, since these two types had similar pathophysiological features represented by the increased proportion of eosinophils in the BAL fluid.

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  • [Characteristics of clinical asthma types in elderly patients with bronchial asthma]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   30 ( 2 )   116 - 22   1993.2

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    Asthma was classified into four types, Ia-1 (bronchospasm with 0-49 ml/day of expectoration), Ia-2 (with 5-99 ml/day), Ib (over 100 ml/day) and II (bronchiolar obstruction), according to clinical symptoms. Characteristics of airway responses in each clinical asthma type were compared between 25 elderly (mean age, 65.2 years) and 30 younger subjects (mean age, 44.9 years) with bronchial asthma, by observing ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. In patients with types 1a-2 and Ib, the %V25 value was significantly lower in the elderly subjects than in the younger subjects. 2. Comparing the values of ventilatory parameters of type Ia-1 cases with other asthma types, %V25 value was lower in other asthma types than in type Ia-1 in the elderly. All ventilatory parameters examined were generally lower in type II cases than in other asthma types in the elderly, but this difference was not significant. In contract, in the younger subjects, the values of %MMF, %V50 and %V25 were significantly lower in type II cases than in other asthma types. 3. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was higher in the younger patients with type II than in the elderly patients with the same type, although there was no significant difference between older and younger subjects. The proportion of BAL eosinophils in patients with type Ib was significantly higher in younger subjects than in elderly subjects. These results indicate that airway responses which are characteristic of each asthma type are stronger in younger patients than in elderly patients.

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  • [Release of histamine and leukotrienes C4 and B4, and bronchial hyperresponsiveness in elderly patients with asthma]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   30 ( 1 )   59 - 64   1993.1

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    Thirty patients with atopic asthma in whose asthma IgE-mediated allergic reaction participates, were selected for this study. They were divided into three age groups: elderly patients aged 60 and over, middle-aged patients between the ages of 40 and 59, and young patients between 20 and 39, to clarify the effects of aging on the mechanism of onset of asthma. In the cellular composition of bronchoalveolar lavage (BAL) fluid, the proportion of BAL lymphocytes was increased in elderly patients, and the proportion of BAL eosinophils was increased in young patients, although there was no statistically significant difference between the proportions of these cells in the three age groups. The proportion of BAL basophilic cells (basophils and mast cells) was significantly lower in elderly patients than in young patients (p < 0.05). The release of histamine from BAL cells was significantly lower in elderly patients than in middle-aged patients (p < 0.05) and young patients (p < 0.02). There was, however, no significant difference between the release of leukotrienes C4 (LTC4) and B4 (LTB4) in the three age groups. The release of histamine, LTC4 and LTB4 from peripheral leucocytes was not significantly different between the three age groups. Finally, Bronchial reactivity to methacholine showed a tendency to decrease with aging.

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  • Airway inflammation and bronchial hyperresponsiveness in patients with asthma. Comparison between atopic and nonatopic asthma. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, T Okano, N Honke, S Tada, K Takahashi, I Kimura

    Arerugi = [Allergy]   42 ( 1 )   26 - 33   1993.1

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    A relationship of cellular composition in the airways and the release of chemical mediators from the cells to bronchial hyperresponsiveness was examined in two age-matched asthma groups: 15 atopic and 15 nonatopic patients. 1. A significant correlation between the proportion of eosinophils in bronchoalveolar lavage (BAL) fluid and bronchial reactivity (BR) was found in patients with atopic and nonatopic asthma. The proportion of the cells (combined eosinophils and neutrophils) in BAL fluid was closely correlated with BR in patients with atopic asthma, but not in those with nonatopic asthma. There was no correlation between the proportion of BAL neutrophils and BR in the two asthma groups. 2. There was a significant correlation between histamine release from BAL cells and BR in patients with atopic asthma. In contrast, LTC4 release from BAL cells was significantly corrected with BR in patients with nonatopic asthma. The results suggest that the humoral and cellular components in the airways, that participate in bronchial hyperresponsiveness, are different between patients with atopic and nonatopic asthma.

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  • Changes in the proportions of bronchoalveolar lymphocytes, neutrophils and basophilic cells and the release of histamine and leukotrienes from bronchoalveolar cells in patients with steroid-dependent intractable asthma. Reviewed International journal

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, I Kimura

    International archives of allergy and immunology   101 ( 2 )   196 - 202   1993

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    The proportion of inflammatory cells in bronchoalveolar lavage (BAL) fluid and the release of chemical mediators from BAL and peripheral blood cells were examined in 40 patients with steroid-dependent intractable asthma (SDIA) to clarify the effects of a long-term glucocorticoid regimen on these cells. The proportion of BAL lymphocytes was significantly reduced (p < 0.01) and the proportion of BAL neutrophils was significantly increased (p < 0.01) in SDIA patients compared with non-SDIA patients. The proportion of basophilic cells (mast cells and basophils) in BAL fluid was significantly lower in SDIA patients compared to non-SDIA patients (p < 0.02). The values of six ventilatory parameters were significantly lower in SDIA patients with a high proportion of BAL neutrophils (more than 10%) compared with the values in non-SDIA patients. The release of histamine and leukotriene C4 (LTC4) from the BAL cells of patients with atopic asthma was significantly reduced in SDIA patients compared with non-SDIA patients (p < 0.05). These results show that the changes in the proportion of BAL cells are observed in patients with SDIA, and these changes are related to suppressed ventilatory function and a reduction in the release of histamine and LTC4 from BAL cells.

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  • Effects of glucocorticoids on humoral and cellular immunity and on airway inflammation in patients with steroid-dependent intractable asthma. Reviewed International journal

    Y Tanizaki, H Kitani, T Mifune, F Mitsunobu, K Kajimoto, K Sugimoto

    The Journal of asthma : official journal of the Association for the Care of Asthma   30 ( 6 )   485 - 92   1993

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    The effects of glucocorticoids on the proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid in relation to humoral and cellular immunity were studied in 56 patients with steroid-dependent intractable asthma. To analyze the mechanism responsible for reduced numbers of BAL lymphocytes, we divided the subjects into 4 groups according to their BAL lymphocyte proportions: 0-4.9%, 5.0-9.9%, 10.0-14.9%, and 15.0-20.0%. Serum IgG levels and the peripheral lymphocyte count were significantly reduced in patients with a low proportion of BAL lymphocytes (less than 9.9%) than in those with more than 10% BAL lymphocytes. Delayed cutaneous reactivity to purified protein derivative was suppressed in patients with a low proportion of BAL lymphocytes (less than 4.9%). The mean proportion of BAL neutrophils tended to increase as the proportion of BAL lymphocytes decreased. These results show that the reduction in BAL lymphocytes produced by glucocorticoids is associated with suppressed humoral and cellular immunity, and that under such conditions the proportion of BAL neutrophils increases.

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  • Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with bronchial asthma. Reviewed International journal

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, I Kimura

    The Journal of asthma : official journal of the Association for the Care of Asthma   30 ( 4 )   257 - 62   1993

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    Mucus hypersecretion was clinically analyzed in 46 adult patients with bronchial asthma, including 22 with steroid-dependent intractable asthma (SDIA). A large amount of expectoration, over 50 ml/day, was observed in 16 of these patients (34.8%), of whom 12 (75.0%) had SDIA and 13 (81.3%) were women. The mean amount of expectoration increased with increasing patient age, although no significant difference was found among the six age groups. A large amount of expectoration (over 50 ml/day) was clearly correlated with an increased proportion of eosinophils in bronchoalveolar lavage (BAL) fluid. The proportion of BAL eosinophils was significantly higher in patients with expectoration between 50 and 99 ml/day (p < 0.05) and over 100 ml/day (p < 0.01) than in patients whose expectoration volume was between 30 and 49 ml/day. These results show that in bronchial asthma patients, mucus hypersecretion is more often observed clinically in those with SDIA and in women, and that this hypersecretion is closely correlated with BAL eosinophilia, which is a feature of the pathophysiological changes that occur in the airways of these patients.

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  • Effects of long-term glucocorticoid therapy on bronchoalveolar cells in adult patients with bronchial asthma. Reviewed International journal

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, I Kimura

    The Journal of asthma : official journal of the Association for the Care of Asthma   30 ( 4 )   309 - 18   1993

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    The effects of long-term glucocorticoid therapy on airway inflammation were examined in 84 asthma patients. The proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly decreased in patients with steroid-dependent intractable asthma (SDIA) compared to results in non-SDIA patients, while BAL neutrophils were significantly increased in SDIA patients compared to results in non-SDIA patients. Regarding age, in patients under the age of 69 (except those between 30 and 39), BAL lymphocyte number was significantly decreased in SDIA compared with non-SDIA subjects, and in patients between 50 and 69, BAL neutrophils were significantly increased in SDIA compared with non-SDIA subjects. The number of BAL lymphocytes was significantly lower in patients with serum cortisol levels of less than 5.0 micrograms/dl than in those with levels of more than 5.1 micrograms/dl. BAL lymphocyte number was also significantly lower in patients who had received glucocorticoid therapy for more than 6 years than in those who had received such therapy for 2 years. These results show that long-term glucocorticoid therapy decreases the number of lymphocytes and increases neutrophil numbers in the airways.

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  • Effects of Salvia Officinalis Extract Bathing on Patients with Bronchial Asthma.

    OKAZAKI Morihiro, KITANI Hikaru, MIFUNE Takashi, MITSUNOBU Fumihiro, TANIZAKI Yoshiro, FUJIWARA Toshio, KAWASAKI Yoshimi

    The Journal of Japanese Balneo-Climatological Association   56 ( 2 )   113 - 118   1993

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    DOI: 10.11390/onki1962.56.113

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 7. Relationship between spa effects and airway inflammation.:7. Relationship between spa effects and airway inflammation

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OCHI Koji, HARADA Hideo, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 2 )   79 - 86   1993

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    DOI: 10.11390/onki1962.56.79

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 9. Suppression of bronchial hyperresponsiveness.:9. Suppression of bronchial hyperresponsiveness

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OKUDA Hiroyuki, OCHI Koji, HARADA Hideo, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 3 )   135 - 142   1993

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    DOI: 10.11390/onki1962.56.135

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  • Clinical Effects of Spa Therapy on Patients with Chronic Obstructive Bronchiolitis.

    TANIZAKI Yoshiro, KITANI Hikaru, MIFUNE Takashi, MITSUNOBU Fumihiro, KAJIMOTO Kazuhiro, NAKAGIRI Yoshiyasu, OCHI Koji, HARADA Hideo, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 4 )   211 - 219   1993

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    DOI: 10.11390/onki1962.56.211

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 11. Effects on asthma in the elderly.:11. Effects on asthma in the elderly

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, NAKAGIRI Yoshiyasu, OCHI Koji, HARADA Hideo, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 4 )   195 - 202   1993

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    DOI: 10.11390/onki1962.56.195

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 12. Effects on Asthma with Hypersecretion.:12. Effects on Asthma with Hypersecretion

    MITSUNOBU Fumihiro, KITANI Hikaru, MIFUNE Takashi, KAJIMOTO Kazuhiro, NAKAGIRI Yoshiyasu, TANIZAKI Yoshiro, OCHI Kouji, HARADA Hideo, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 4 )   203 - 210   1993

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    DOI: 10.11390/onki1962.56.203

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 8. Effects on suppressed function of adrenocortical glands.:8. Effects on suppressed function of adrenocortical glands

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OKUDA Hiroyuki, OCHI Koji, HARADA Hideo, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 2 )   87 - 94   1993

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    DOI: 10.11390/onki1962.56.87

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 10. Effects on asthma with bronchiolar obstruction.:10. Effects on asthma with bronchiolar obstruction

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, NAKAGIRI Yoshiyasu, OCHI Koji, HARADA Hideo, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   56 ( 3 )   143 - 150   1993

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    DOI: 10.11390/onki1962.56.143

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  • Asthma classification by pathophysiology and IgE-mediated allergic reaction: new concepts for classification of asthma. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, N Honke, Y Kusaura, I Kimura

    Acta medica Okayama   46 ( 5 )   381 - 7   1992.10

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    Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).

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  • Pathophysiological changes in the airways of asthma patients with aging. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, N Honke, I Kimura

    Arerugi = [Allergy]   41 ( 9 )   1380 - 7   1992.9

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    Pathophysiological changes in the airways with aging were examined in 78 patients with bronchial asthma. The FEV1.0% values in patients over the age of 71, and the %MMF, %V50 and %V25 values in those over 51 were significantly lower than those of patients between the ages of 10 and 30. The frequency of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly higher in patients aged between 61 and 70 than in those aged between 41 and 50 (p < 0.05). The frequency of each clinical asthma type changed with aging; the number of patients with simple bronchoconstriction type (type Ia) decreased with increasing age in patients under the age of 60, and the number of those with bronchiolar obstruction type (type II) increased with aging. The frequency of patients with bronchoconstriction+hypersecretion type (type Ib) showed a peak between the ages of 51 and 60. Bronchial reactivity to methacholine showed a tendency to decrease with aging. The release of histamine from leucocytes induced by Ca ionophore A23187 was significantly higher in patients between the ages of 10 and 30 than in those between the ages of 51 and 60 (p < 0.05) and between 61 and 70 (p < 0.01).

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  • Food-dependent exercise-induced anaphylaxis. Reviewed

    M Okazaki, H Kitani, T Mifune, F Mitsunobu, S Saito, N Asaumi, Y Tanizaki

    Internal medicine (Tokyo, Japan)   31 ( 8 )   1052 - 5   1992.8

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    A 58-year-old farmer was admitted to our hospital because of repeated episodes of anaphylaxis. He had experienced 12 episodes of anaphylactic shock over the previous 17 years. These attacks included three episodes of bee sting. In general, the episodes occurred during farm work (exercise) and within two hours of eating cake in the afternoon. Because an immediate skin reaction to wheat flour was highly positive, a diagnosis of wheat allergy was considered. These findings suggested that his illness was consistent with food-dependent exercise-induced anaphylaxis.

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  • Asthma classification by a score calculated from clinical findings and examinations in subjects sensitive to inhalant allergens. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, M Tanimizu, N Honke, Y Kusaura, K Ochi, H Harada

    Acta medica Okayama   46 ( 4 )   295 - 301   1992.8

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    Twenty-one patients with atopic asthma were classified into three types according to their symptoms (clinical diagnosis): Ia, simple bronchoconstriction; Ib, bronchoconstriction + hypersecretion; and II, bronchiolar obstruction, and this classification was compared with a classification made according to clinical findings and examinations (score diagnosis). Type Ib asthma was characterized by the increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF), while type II was characterized by ventilatory dysfunction in small airways and the increased incidence of neutrophils in BALF. Four patients, whose expectoration was between 50 and 99ml/day, of the 12 with type Ia assessed by clinical diagnosis were evaluated as type Ib by score diagnosis. One patient with type II by clinical diagnosis was assessed as questionable type II by score diagnosis. In the other 16 patients, the clinical and score diagnoses were the same.

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  • Spa therapy improves ventilatory function in the small airways of patients with steroid-dependent intractable asthma (SDIA). Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, K Ochi, H Harada, I Kimura

    Acta medica Okayama   46 ( 3 )   175 - 8   1992.6

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    The improvement of ventilatory function by spa therapy was examined in 37 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. All subjects had been on long-term corticosteroid therapy before spa therapy. Spa therapy was found to improve the values of ventilatory parameters. The percent improvement in all subjects was +4.1% in %FVC, +8.9% in FEV1.0%, +9.8% in %PEFR, +22.0% in %MMF, +19.7% in %V50 and +28.2% in %V25, respectively. Relating to clinical asthma types, moderate improvement in %MMF and %V25 from 16.7% to 16.9% was observed in type Ia cases, and marked increase in %MMF, %V50 and %V25 was observed from 42.2% to 43.2% in type Ib cases. However, no significant increase was found in these parameters of types Ia or Ib after spa therapy. In patients with type II, a significant increase was shown in %V50 (p less than 0.05) and %V25 (p less than 0.01) after spa therapy. The results show that spa therapy improves the condition of small airways disorder in patients with SDIA.

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  • Humoral and cellular immunity to Candida albicans in patients with bronchial asthma. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu

    Internal medicine (Tokyo, Japan)   31 ( 6 )   766 - 9   1992.6

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    Delayed cutaneous reactivity to Candida albicans (C. albicans) and PPD (purified protein derivative) was examined in 52 patients with bronchial asthma in relation to the production of specific IgG4 antibodies against the antigen. 1. The frequency of a positive, immediate skin reaction to C. albicans was similar among the five age groups, ranging from 60.0% to 66.7%. 2. The incidence of a positive delayed skin reaction to C. albicans was lower in patients between the ages of 10 and 30 and tended to decrease with aging in the patients over the age of 51. 3. A delayed skin reaction to PPD was positive in patients between 31 and 50 with a higher incidence; this incidence decreased in patients over age 51. 4. The level of C. albicans-specific IgG4 antibodies was significantly higher (26.7 u/ml) in patients with a negative delayed skin reaction to the antigen than in those with a positive reaction (5.9 u/ml) (p less than 0.001). There was no correlation between delayed skin reaction to PPD and production of specific IgG4 antibodies.

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  • [Asthma classification by score calculated from clinical findings and examinations. Comparison between clinical diagnosis and score diagnosis]. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, N Kotoh, S Tada, K Takahashi, I Kimura

    Arerugi = [Allergy]   41 ( 4 )   489 - 96   1992.4

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    Asthma classification by clinical symptoms and signs (clinical diagnosis) was compared with the classification by score calculated from clinical findings and examinations (score diagnosis) in 25 patients with bronchial asthma. 1. Ten subjects classified as Ia (simple bronchoconstriction type) by clinical diagnosis were divided into 6 cases with expectoration of less than 49 ml a day and 4 cases with expectoration of between 50 and 99 ml. The level of serum IgE and number of eosinophils in BALF were significantly higher in the latter cases than in the former cases. The cases whose expectoration was from 50 to 99 ml a day were classified as Ib (bronchoconstriction with hypersecretion type) by score diagnosis. 2. The six subjects who were classified as type Ib by clinical diagnosis were also evaluated as type Ib by score diagnosis. 3. Nine of the 10 subjects classified as type II by clinical diagnosis were evaluated as type II by score diagnosis. One case, whose score was under 12 points, was evaluated as questionable type II by score diagnosis.

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  • Cellular composition of fluid in the airways of patients with house dust sensitive asthma, classified by clinical symptoms. Reviewed

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu, K Ochi, H Harada

    Internal medicine (Tokyo, Japan)   31 ( 3 )   333 - 8   1992.3

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    The cellular composition of bronchoalveolar lavage (BAL) fluid was observed in 28 patients with house dust mite-sensitive asthma. The proportion of neutrophils in the BAL fluid was significantly higher in the patients between the ages of 50 and 59 and those over 60 than in the patients younger than age 39. There was a significant difference in the number of neutrophils in patients aged 30-39 years and in those over 40 at the onset of disease. The cellular composition varied among the three types of asthma; the mean percentage of cells in the BAL fluid was 1.1% neutrophils and 21.3% eosinophils in type Ia (simple bronchoconstriction), 9.1% neutrophils and 23.0% eosinophils in type Ib (bronchoconstriction + hypersecretion), and 34.4% neutrophils and 12.0% eosinophils in type II (bronchiolar obstruction). The results suggested that an increased frequency of both neutrophils and eosinophils correlates with the mechanism of hypersecretion, and that a marked increase in the proportion of neutrophils is involved in bronchiolar obstruction.

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  • An increased level of specific IgG4 antibodies against Candida albicans in patients with bronchial asthma. Reviewed International journal

    Y Tanizaki, H Kitani, M Okazaki, T Mifune, F Mitsunobu

    The Journal of asthma : official journal of the Association for the Care of Asthma   29 ( 5 )   343 - 8   1992

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    Specific IgG4 antibodies against Candida albicans in sera were measured in 76 asthmatics. The increased level of specific IgG4 was found in cases 10-40 years old sensitive to house dust mite and/or Candida albicans, in cases with steroid-dependent intractable asthma (SDIA) and in elderly cases. The frequency of SDIA was the highest in cases 41 to 60 years old with higher frequency of increased IgG4 antibodies. The results show that specific IgG4 increases in relation to IgE-mediated immune response, long-term steroid therapy, and aging. All of these conditions may induce depressed cell-mediated immunity.

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 6. Comparison among three kinds of spa therapies.:6. Comparison among three kinds of spa therapies

    MITSUNOBU Fumihiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, OKUDA Hiroyuki, TANIZAKI Yoshiro

    The Journal of Japanese Balneo-Climatological Association   55 ( 4 )   185 - 190   1992

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    DOI: 10.11390/onki1962.55.185

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 2. Relationship to ventilatory function.:2. Relationship to ventilatory function

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OKUDA Hiroyuki, TAKATORI Akimasa, OCHI Kouji, HARADA Hideo

    The Journal of Japanese Balneo-Climatological Association   55 ( 2 )   82 - 86   1992

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    DOI: 10.11390/onki1962.55.82

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 3. Efficacy of fango therapy.:3. Efficacy of fango therapy

    KITANI Hiraku, MITSUNOBU Fumihiro, MIFUNE Takashi, OKAZAKI Morihiro, TANIZAKI Yoshiro

    The Journal of Japanese Balneo-Climatological Association   55 ( 3 )   127 - 133   1992

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    DOI: 10.11390/onki1962.55.127

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 4. Effects on steroid-dependent intractable asthma(SDIA).:4. Effects on steroid-dependent intractable asthma (SDIA)

    TANIZAKI Yoshiro, KITANI Hiraku, OKAZAKI Morohiro, MIFUNE Takashi, MITSUNOBU Fumihiro, TAKATORI Akimasa, OKUDA Hiroyuki, OCHI Kouji, HARADA Hideo

    The Journal of Japanese Balneo-Climatological Association   55 ( 3 )   134 - 138   1992

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    DOI: 10.11390/onki1962.55.134

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 1. Relationships to clinical asthma types and patient age.:1. Relationships to clinical asthma types and patient age

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OKUDA Hiroyuki, TAKATORI Akimasa, OCHI Kouji, HARADA Hideo

    The Journal of Japanese Balneo-Climatological Association   55 ( 2 )   77 - 81   1992

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    DOI: 10.11390/onki1962.55.77

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  • Clinical Effects of Spa Therapy on Bronchial Asthma. 5. Efficacy of inhalation with iodine salt solution.:5. Efficacy of inhalation with iodine salt solution

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, OKUDA Hiroyuki, OCHI Kouji, HARADA Hideo, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   55 ( 4 )   179 - 184   1992

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    DOI: 10.11390/onki1962.55.179

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  • Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma. Reviewed

    M Okazaki, H Kitani, T Mifune, F Mitsunobu, N Asaumi, Y Tanizaki, H Harada, K Takahashi, I Kimura

    Acta medica Okayama   45 ( 4 )   267 - 73   1991.8

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    Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

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  • Eight-year Study on Spa Therapy for Patients with Chronic Respiratory Disease. Annual changes in background and characteristics of asthmatics.:Annual changes in background and characteristics of asthmatics

    TANIZAKI Yoshiro, KITANI Hikaru, OKAZAKI Morihiro, MIFUNE Takashi, MITSUNOBU Fumihiro, TAKATORI Akimasa, OKUDA Hiroyuki, SODA Mitsuhiro, TAKAHASHI Kiyoshi, KIMURA Ikuro

    The Journal of Japanese Balneo-Climatological Association   54 ( 3 )   161 - 167   1991

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    Annual changes in age, age at onset, incidence of cases with steroiddependent intractable asthma, clinical asthma types and clinical efficacy rate were examined in 256 patients with chronic respiratory diseases, especially in 203 cases with bronchial asthma, admitted to Misasa Branch Hospital from 1982 to 1989.<br>1. A number of patients with respiratory diseases as well as asthmatics admitted each year, having spa therapy, increased from early year (1982) to later year (1989).<br>2. A number in cases with 40 year or over of age (also with 60 year or over of age) and cases with 40 year or over of age at onset showed a tendency to increase in later three years (1987-1989). A decreased frequency of cases with steroid-dependent asthma and of cases with type II (bronchiolar obstruction type) was observed in the later three years.<br>3. The clinical efficacy of spa therapy for bronchial asthma was Niger in the later three years than in early three years (1982-1984).

    DOI: 10.11390/onki1962.54.161

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  • Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Reviewed International journal

    T J Bos, F S Monteclaro, F Mitsunobu, A R Ball Jr, C H Chang, T Nishimura, P K Vogt

    Genes & development   4 ( 10 )   1677 - 87   1990.10

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    To assess the transforming capability of the c-Jun protein, we introduced the chicken c-jun proto-oncogene into a replication competent avian retroviral expression vector (RCAS). Viral Jun efficiently transformed chicken embryo fibroblasts (CEFs) when expressed from this vector. Overexpression of c-Jun leads to transformation of CEFs with an efficiency that is 15- to 25-fold less than that seen for v-Jun, suggesting that v-Jun contains structural features that increase its oncogenic potential relative to c-Jun. There are four structural differences between v-Jun and c-Jun. To determine the relative contribution that each of these structural differences between v-Jun and c-Jun has on oncogenic activity, several deletion and substitution mutants were constructed. Each of these mutants was expressed in CEF and assayed for transformation by focus formation. Analysis of the results reveals that deletion of a region of 27 amino acids near the amino terminus of c-Jun and deletion of 3'-untranslated sequences are critical in activating the full oncogenic potential of Jun.

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  • A mechanism of c-raf-1 activation: fusion of the lipocortin II amino-terminal sequence with the c-raf-1 kinase domain. Reviewed International journal

    F Mitsunobu, M Fukui, T Oda, T Yamamoto, K Toyoshima

    Oncogene   4 ( 4 )   437 - 42   1989.4

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    In order to understand the mechanism of oncogenic activation, we have analyzed the c-raf-1 gene from the GL-5-JCK human glioblastoma, which underwent rearrangement during transfection experiments. Nucleotide sequencing of cDNA clones derived from the 2.5 kb raf-mRNA, which is a major transcript of raf in NIH3T3 cells transformed with GL-5-JCK DNA, revealed that this mRNA contains sequences derived from the human c-raf-1 gene and the human lipocortin II gene. Translation of the 2.5 kb raf-mRNA predicted a fusion protein consisting of 16 amino-terminal amino acid residues of the lipocortin II and 370 carboxy-terminal amino acid residues of the c-raf-1 protein which contains the kinase domain. Expression of the lipocortin II-raf cDNA using the murine sarcoma virus long terminal repeat as promoter resulted in the transformation of NIH3T3 cells.

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  • Molecular cloning, complete nucleotide sequence, and gene structure of the provirus genome of a retrovirus produced in a human lymphoblastoid cell line. Reviewed International journal

    T Oda, S Ikeda, S Watanabe, M Hatsushika, K Akiyama, F Mitsunobu

    Virology   167 ( 2 )   468 - 76   1988.12

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    We found and characterized a type D retrovirus produced in a human lymphoblastoid cell line of B-cell lineage. The amino acid sequence of the N-terminal region of the purified major structural protein (PVTRSQGQVSSNTTGRASPHPDTHTIPE) revealed no high homology with any of the known retroviral amino acid sequences. We have cloned cDNA and the proviral genome integrated in the retrovirus-producing cells, and determined the complete nucleotide sequence and gene structures of the genome. The provirus genome is 8785 bp long and has the structure of LTR-gag-prt-pol-eny-LTR. The nucleotide sequences of the long terminal repeat (LTR) region and a part of the pol gene were closely related to the available sequences of squirrel monkey retrovirus (SMRV), and we designated this virus SMRVHLB' abbreviated as SMRV-H. The primer (tRNA(Lys)1,2)-binding sequence of SMRV-H (TGGCGCCCAGGACGTGGGGCTCGA) has a GG insertion, which is different from that of SMRV. The transmembrane protein of the 3' terminal region of env gene contains an amino acid sequence of an immunosuppressive peptide (EVVLQNRRGLDLLTAEQGGICLALQERCCFYANKS), in which R is unique in SMRV-H. The core sequence of the glucocorticoid regulatory element is found upstream of the two 42-bp imperfect repeats in the LTR. Sequences partially homologous to those of the rat IgE-binding protein gene are in gag and pol genes.

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  • Molecular cloning and characterization of an activated human c-raf-1 gene. Reviewed International journal

    M Fukui, T Yamamoto, S Kawai, F Mitsunobu, K Toyoshima

    Molecular and cellular biology   7 ( 5 )   1776 - 81   1987.5

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    Results of previous studies have shown that a raf-related transforming DNA sequence is present in NIH 3T3 transformants that are derived from GL-5-JCK human glioblastoma DNA transfection. The transforming DNA was molecularly cloned by using cosmid vector pJB8 to determine its structure and origin. Analyses of selected clones revealed that the transforming DNA consisted of three portions of human DNA sequences, with the 3' half of the c-raf-1 gene as its middle portion. This raf region was about 20 kilobases long and contained exons 8 to 17 and the poly(A) addition site. RNA blot analysis showed that the raf-related transforming DNA was transcribed into 5.3-, 4.8-, and 2.5-kilobase mRNAs; the 2.5-kilobase transcript was thought to be the major transcript. Immunoprecipitation analyses revealed that a 44-kilodalton raf-related protein was specifically expressed in the NIH 3T3 transformants. The raf-related transforming DNA was considered to be activated when its amino-terminal sequence was truncated and the DNA was coupled with a foreign promoter sequence. On hybridization analysis of the original GL-5-JCK glioblastoma DNA, no rearrangement of c-raf-1 was detectable in the tumor DNA. The rearrangement of c-raf-1 may have occurred during transfection or may have been present in a small population of the original tumor cells as a result of tumor progression.

    PubMed

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  • Expression of simian virus 40 small t antigen in Escherichia coli and purification of the antigen. Reviewed International journal

    S Ikeda, K Akiyama, F Mitsunobu, T Wada, M Hatsushika, S Watanabe, K Tsutsui, S Seki, T Oda

    Archiv fur Geschwulstforschung   57 ( 4 )   275 - 81   1987

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    A simian virus 40 (SV 40) DNA fragment encoding small t antigen was cloned in expression vector pUC8 for the purification of the antigen. The SV40 Hind III B fragment was inserted into the Hind III site of pUC8. A plasmid having the lacZ' and small t antigen genes in the same orientation was designated as pSVt. pSVt encodes the entire small t antigen and an extra 18 amino acids at the amino terminus of the antigen. E. coli transformed with pSVt produced hybrid small t antigen (22 kDa) which comprised about 6% of the total protein. The hybrid small t antigen reacted in immunoblot analysis with SV40-induced tumor-bearing hamster serum. Hybrid small t antigen was extracted from E. coli, and purified by preparative SDS-PAGE. The antigen was extracted from the gel using formic acid solution with high-yield. The gel-purified antigen showed the same antigenic reactivity as crude antigen.

    PubMed

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Books

  • 休養学基礎 : 疲労を防ぐ!健康指導に活かす : 正しい休養、評価、指導のすすめ方

    杉田, 正明, 片野, 秀樹, 日本リカバリー協会( Role: Contributor ,  【1章-2】休養モデルを促進する介入法と理論 ①入浴と温泉)

    メディカ出版  2021.7  ( ISBN:9784840475662

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    Total pages:225p   Language:Japanese

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  • Animal Study on Biological Responses by Radon Inhalation Making Use of Waste Rock which Contains Feeble Activity of Uranium (2) (Joint Research)

    Yuu Ishimori][Akihiro Sakoda][Hiroshi Tanaka][Fumihiro Mitsunobu][Kiyonori Yamaoka][Takahiro Kataoka][Reo Etani( Role: Joint author)

    Ningyo-toge Environmental Engineering Center, Sector of Decommissioning and Radioactive Waste Management, Japan Atomic Energy Agency  2016 

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  • The Possible Applications ofActivation of Bio-defense System by Radon Inhalation and its Applicable Possibility for Treatment of Lifestyle Diseases "jointly worked"

    ( Role: Joint author)

    Nova Science Publishers  2015.4 

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    Responsible for pages:133-148   Language:English

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  • The Possible Applications of Radon Inhalation Treatment as Antioxidant Therapy for Hepatopathy. Radon: Geology, Environmental Impact and Toxicity Concerns. "jointly worked"

    ( Role: Joint author)

    Nova Science Publishers  2015 

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    Responsible for pages:133-148   Language:English

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  • 極微量ウラン影響効果試験{共同研究}(共著)

    日本原子力研究開発機構 バックエンド研究開発部門 人形峠環境技術センター  2013 

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  • Animal Study on Biological Responses by Radon Inhalation Making Use of Waste Rock which Contains Feeble Activity of Uranium (Joint Research),"jointly worked"

    Yuu Ishimori][Akihiro Sakoda][Hiroshi Tanaka[Yuu Ishimori][Akihiro Sakoda][Hiroshi Tanaka][Fumihiro Mitsunobu][Kiyonori Yamaoka, ][Takahiro Kataoka][Reo Etani][Keiko Yamato][Yuuichi NIshiyama( Role: Joint author)

    Ningyo-toge Environmental Engineering Center, Sector of Decommissioning and Radioactive Waste Management, Japan Atomic Energy Agency  2013 

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  • Medical Guidebooku of Radioactive Spring

    Fumihiro Mitsunobu et. al( Role: Joint author)

    2012  ( ISBN:9784990469412

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    Responsible for pages:65-81   Language:Japanese

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  • 温泉の百科事典

    Fumihiro Mitsunobu( Role: Sole author)

    2012  ( ISBN:9784621085066

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    Responsible for pages:205-206, 209-210   Language:Japanese Book type:Dictionary, encyclopedia

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  • 放射線の安全に関するガイドブックー放射線と健康(共著)

    株式会社 ヒューレックス  2012  ( ISBN:9784990469412

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  • 診療の秘訣

    *光延文裕 他(診療の秘訣)

    新興医学出版社  2008 

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  • 「呼吸器疾患の運動療法と運動負荷テスト」

    光延 文裕

    克誠堂出版,東京  2007 

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    Responsible for pages:pp166-171  

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  • 「新入浴・温泉療法マニュアル」

    光延 文裕

    日本温泉気候物理医学会,東京  2007 

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    Responsible for pages:pp37-40  

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  • 「高齢者のための温泉療法」

    光延 文裕

    ライフ・サイエンス,東京  2007 

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    Responsible for pages:pp242-250  

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 新温泉医学

    *光延文裕、谷崎勝朗(?.温泉医学各論 1.温泉入浴の病態生理 温泉入浴と自律神経機能)

    日本温泉気候物理医学会  2004 

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    Responsible for pages:212-218  

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 新温泉医学

    日本温泉気候物理医学会  2004 

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  • 気道炎症におけるサイトカインネットワークと細胞内シグナル伝達に関する研究

    光延, 文裕

    光延文裕  2002.3 

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  • 平成11-13年度科学研究費補助金(基盤研究C)成果報告書

    光延文裕(気道炎症におけるサイトカインネットワークと細胞内シグナル伝達に関する研究)

    2001 

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MISC

  • ラドン吸入によるDNA酸化損傷の抑制効果に関する検討 Reviewed

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会プログラム・抄録集   74th (CD-ROM)   2021

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    J-GLOBAL

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  • The differences in redox status in mice organs affect the activation of antioxidative functions by radon inhalation Reviewed

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会秋の大会予稿集(CD-ROM)   2020   2020

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    J-GLOBAL

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  • Radon inhalation time dependent changes of hydrogen peroxide production in mice organs Reviewed

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会春の年会予稿集(CD-ROM)   2020   2020

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    J-GLOBAL

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  • ラドン吸入がマウス脳・肝臓に及ぼす酸化ストレスの変化特性 Reviewed

    片岡隆浩, 神崎訓枝, 迫田晃弘, 首藤妃奈, 矢野準喜, 直江翔太, 石田毅, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本酸化ストレス学会学術集会プログラム・抄録集   73rd   2020

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    J-GLOBAL

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  • The 84th Annual Meeting of the Japanese Society of Balneology, Climatology and Physical Medicine (BCPM) Invited

    Fumihiro Mitsunobu

    Okayama Igakkai Zasshi (Journal of Okayama Medical Association)   131 ( 3 )   171 - 172   2019.12

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    Authorship:Lead author   Language:Japanese   Publishing type:Meeting report   Publisher:Okayama Medical Association  

    DOI: 10.4044/joma.131.171

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  • Treatment results and research trends of radon therapy Invited

    Fumihiro Mitsunobu

    Journal of the Atomic Energy Society of Japan ATOMOΣ   61 ( 2 )   146 - 147   2019.2

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Atomic Energy Society of Japan  

    DOI: 10.3327/jaesjb.61.2_146

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  • ラドン吸入による抗酸化機能の亢進がマウス諸臓器中の過酸化水素産生に及ぼす作用

    片岡隆浩, 神崎訓枝, 迫田晃弘, 石田毅, 首藤妃奈, 矢野準喜, 田中裕史, 花元克巳, 寺東宏明, 光延文裕, 山岡聖典

    日本原子力学会中国・四国支部研究発表会要旨集   13th   2019

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    J-GLOBAL

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  • ラドンの皮脂成分での溶解特性

    石田 毅, 迫田 晃弘, 片岡 隆浩, 神崎 訓枝, 田中 裕史, 小橋 佑介, 柚木 勇人, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会大会講演要旨集   61回   79 - 79   2018.11

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  • ラドン療法条件の最適化に関する基礎的検討

    片岡 隆浩, 恵谷 玲央, 神崎 訓枝, 笹岡 香織, 迫田 晃弘, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会大会講演要旨集   59回   13 - 13   2016.10

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  • ラドン温泉における吸入または飲泉による高尿酸血症の抑制効果の比較検討

    恵谷 玲央, 片岡 隆浩, 神崎 訓枝, 迫田 晃弘, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    放射線ワークショップ講演論文集   1回   86 - 87   2015.10

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  • 三朝ラドン温泉の健康効果に関する最近の研究動向(共著)

    片岡隆浩, 迫田晃弘, 恵谷玲央, 石森 有, 光延文裕, 山岡聖典

    温泉科学   64 ( 4 )   380 - 387   2015

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    岡山大学病院三朝医療センターではラドン温泉を活用したラドン療法が実施されており、適応症として例えば変性性関節症に伴う疼痛がある。臨床試験による実証報告例は多くあるものの、なぜ有効であるかのメカニズムの解明に関する研究報告例は少ない。本稿では、放射能効果の観点から近年得られた筆者らのラドン健康効果の研究成果を中心に概説した。すなわち、小動物用ラドン吸入装置を開発し、三朝医療センターに隣接した三朝ラドン効果研究施設内に設置した。これを用い、例えば、マウス諸臓器中の抗酸化酵素活性のラドン濃度・吸入時間の依存性について検討した。その結果、多くの臓器でsuperoxide dismutase(SOD)活性が増加したことから、ラドン吸入は抗酸化機能を亢進させることがわかった。また、streptozotocin(STZ)誘導マウスI型糖尿病の症状緩和について検討した。その結果、ラドン吸入による膵臓中の抗酸化機能の亢進に伴い膵島の酸化ストレスが緩和されることでインスリンの分泌機能の低下が抑制され、I型糖尿病が緩和することもわかった。以上の所見などから、ラドン吸入は抗酸化機能などを亢進させ活性酸素由来の疾患の症状を緩和するメカニズムの一端が明らかにできた。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00191&link_issn=&doc_id=20150513080001&doc_link_id=%2Ffd5onsen%2F2015%2F006404%2F003%2F0380-0387%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffd5onsen%2F2015%2F006404%2F003%2F0380-0387%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • ラドン含有の吸入と飲泉によるマウス1型糖尿病の抑制効果の比較検討

    片岡 隆浩, 西山 祐一, 迫田 晃弘, 恵谷 玲央, 神崎 訓枝, 田中 裕史, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会大会講演要旨集   57回   159 - 159   2014.9

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  • ラドン吸入によるマウス腎障害の抑制効果における抗酸化機能の関与の検討

    恵谷 玲央, 片岡 隆浩, 西山 祐一, 迫田 晃弘, 神崎 訓枝, 田中 裕史, 石森 有, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会大会講演要旨集   57回   136 - 136   2014.9

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  • Complex Spa Therapy for Chronic Respiratory Disease

    ASHIDA Kozo, TAKATA Shingo, KIKUCHI Hiroshi, HOSAKI Yasuhiro, MITSUNOBU Fumihiro

    The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine   78 ( 1 )   35 - 36   2014

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    DOI: 10.11390/onki.78.35

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  • ラドン吸入によるマウス肝障害の抑制効果とその医療応用の可能性

    片岡 隆浩, 西山 祐一, 恵谷 玲央, 高田 裕司, 迫田 晃弘, 石森 有, 光延 文裕, 田口 勇仁, 山岡 聖典

    日本放射線影響学会大会講演要旨集   56回   145 - 145   2013.10

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  • 慢性閉塞性肺疾患患者の運動耐容能に対する温泉療法の有効性の検討

    高田 真吾, 芦田 耕三, 保崎 泰弘, 岩垣 尚史, 菊池 宏, 光延 文裕, 渡邉 益宜

    鳥取医学雑誌   36 ( 4 )   149 - 149   2008.12

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  • 長期吸入療法患者に対する吸入薬再指導の有用性について

    小沼 利光, 河崎 陽一, 勝部 理早, 名和 秀起, 千堂 年昭, 光延 文裕

    日本病院薬剤師会雑誌   44 ( 11 )   1615 - 1618   2008.11

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    慢性呼吸器疾患において吸入薬が重要な治療薬とされているが、正しい吸入手技を行っているにもかかわらず、患者が手技に不安を感じている症例を経験した。そこで、吸入薬のアドヒアランス向上を目的として、吸入療法を継続的に行っている入院患者に改めて吸入指導を行った。サルメテロール、フルチカゾン、チオトロピウム、ブデソニドのいずれか1つ以上を吸入している患者を対象に、正しく吸入できるようになるまで1週間ごとに服薬指導を行った。どの器具においてもほぼすべての患者が吸入器具をセットできていたが、約半数程度の患者が息止めをできていなかった。また、指導回数3回以上を要した患者は14.3%であり、再指導の必要性が明らかとなった。継続使用している患者においては器具の手技よりも吸入動作に問題点があることが示唆されたため、薬剤師をはじめとする医療スタッフは、吸入動作の確認に重点をおいて再指導を行うことが重要であると考えられた。(著者抄録)

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  • 21-P2-387 不溶性微粒子数測定器を用いた注射剤混合調製による配合変化の検討(品質管理,来るべき時代への道を拓く)

    成本 由佳, 河崎 陽一, 名和 秀起, 光延 文裕, 千堂 年昭

    日本医療薬学会年会講演要旨集   18   2008.9

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  • 呼気流量を考慮することにより吸入器具を変更できた一症例

    小沢利光, 河崎陽一, 勝部理早, 名和秀起, 光延文裕

    岡大三朝医療センター研究報告   76   49 - 52   2008

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  • 2002-2007年における当院市中肺炎入院症例の臨床的研究

    高田真吾, 保﨑泰弘, 芦田耕三, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   12 - 17   2008

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  • 呼吸器疾患の温泉療法ー25年間の入院症例2762例を対象にー

    光延文裕, 保﨑泰弘, 芦田耕三, 岩垣尚史, 高田真吾, 菊池宏, 濱田全紀

    岡大三朝医療センター研究報告   76   1 - 11   2008

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  • A case with persistent asthma symptoms despite fluticasone treatment in which concomitant treatment with montelukast and perilla seed oil-rich supplementation significantly improved asthma control

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    岡大三朝医療センター研究報告   76   53 - 59   2008

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  • Effect of spa Therapy on the six-minute Walk Test in patients with chronic obstructive pulmonary disease

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    岡大三朝医療センター研究報告   76   24 - 30   2008

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  • 肝細胞癌の経過中に肝原発腺扁平上皮癌を合併した1例

    高田真吾, 芦田耕三, 保﨑泰弘, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   41 - 48   2008

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  • ケトプロフェン湿布剤により全身性麻疹様紅斑を来した1例

    高田真吾, 芦田耕三, 保﨑泰弘, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   35 - 40   2008

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  • 帯状疱疹後神経痛に対する温泉を利用したリハビリテーションの経験

    濱田全紀, 光延文裕, 保﨑泰弘, 芦田耕三, 岩垣尚史, 高田真吾, 菊池宏

    岡大三朝医療センター研究報告   76   31 - 34   2008

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  • 慢性閉塞性肺疾患患者の運動耐容能・肺機能に対する温熱療法の有効性についての検討ーpilot study-

    菊池宏, 保﨑泰弘, 芦田耕三, 濱田全紀, 岩垣尚史, 高田真吾, 光延文裕

    岡大三朝医療センター研究報告   76   18 - 23   2008

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  • 慢性閉塞性肺疾患治療の進歩-安定期の治療を中心に-

    光延文裕

    鳥取医学雑誌   36   107 - 113   2008

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  • IgG4関連疾患

    平松万尚, 浅野基, 松下公紀, 三好智子, 中村好男, 水島孝明, 小出典男, 片岡仁美, 越智浩二, 光延文裕

    岡大三朝医療センター研究報告   60 - 65   2008

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  • 気管支喘息における高分解能CT(high-resolution computed tomography)による評価の有用性 : 岡山大学医学賞(砂田賞)を受賞して

    光延 文裕

    岡山醫學會雜誌   116 ( 3 )   229 - 234   2005.1

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    Language:Japanese   Publisher:岡山医学会  

    気管支喘息は気道の慢性炎症性疾患であり, 本質的に可逆性障害と考えられるが, 持続的慢性炎症によって生ずる肺実質を含む気道の器質的変化すなわち気道リモデリングが原因で不可逆性気流制限をきたし得ることが知られている. 最近, 高分解能CT (HRCT; high-resolution computed tomography) によって気管支壁肥厚, 気管支拡張, 気腫化, モザイク状低吸収域などの変化の評価が可能であることが報告されている. 気管支喘息患者の気道壁は健常者に比較して肥厚しており, その肥厚の程度は喘息の重症度, 気流制限, 気道反応性に関連していることが明らかになっている. 気道リモデリングを反映するHRCTの異常所見は, 慢性気流制限を有する重症喘息患者においてしばしば認められ, 長期の罹病期間や強い気道炎症と関係するとされている. 我々は, HRCTにおける-950Hounsfield unit (HU) 以下のlow attenuation area (RA(950)) は非喫煙喘息患者においても検出され, 気流制限, 肺気量, 喘息の重症度と相関しているが, 肺拡散能との有意の相関は認めないことを報告してきた. 最近, フラクタル解析によってRA(950)は, 喫煙歴を有する喘息患者では気腫性変化を示すのに対し, 非喫煙喘息患者では非気腫性変化 (過膨張) を示す可能性を示した. さらに, HRCTによって評価された気道壁肥厚およびRA950は, 治療によって改善することが認められており, HRCTは喘息の治療効果判定に有用である可能性が示唆された.

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  • ベラプロスト投与におけるASO患者の末梢循環の改善効果

    保崎泰弘, 光延文裕

    Progress in medicine   2005

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  • Manifold Effects of Thermal Therapy

    KUBOTA Kazuo, MITSUNOBU Fumihiro

    68 ( 1 )   17 - 17   2004.11

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  • Enhanced leukotriene generation and bronchial hyperresponsiveness in asthmatics with allergic rhinitis

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Fujii M, Takata S, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004

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  • Characteristics of the eldely in high-resolition computed tomography ling densitometry.

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Yokoi Y, Hamada M, Tanizaki Y

    Ann Rep Misasa med Center Okayama Univ. Med Dent Sch.   2004

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  • Cigarette smoking enhances LTB4generation by leucocytes associated with bronchial hyperresponsiveness in asthma in the elderly.

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Yokoi T, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ.med Dent Sch.   2004

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  • Clinical effects of longterm spa therapy on pulmonary emphysema.Evaluation by pulmonary function and pathological changes of termonal airspace of the lung.

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Yokoi T, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Dent Sch.   2004

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  • Spa therapy and bronchial hyperresponsiveness associated with cigarette smoking in asthmatics in the elderly

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Fujii M, Takata S, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004

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  • Comparison of pathophysiological changes of asthma between younger and older patients with asthma in relation to long-term cigarette smoking

    Mitsunobu F, Hosaki Y, Ashida K, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004

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  • Effects of spa therapy on reduction of the costs of the drugs used for the treatment of asthma in the elderly in relation to disease severity

    Ashida K, Mitsunobu F, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004

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  • 高齢者喘息における気腫化傾向 加齢変化と病的変化(肺気腫)の相違点

    光延文裕, 保崎泰弘, 芦田耕三, 岩垣尚史, 永田拓也, 藤井誠, 濱田全紀, 谷崎勝朗

    岡山大学三朝医療センター研究報告   2004

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  • 気管支喘息患者におけるモンテルカストの有用性についての検討

    北村佳久, 三宅悟, 横山紀子, 川上英冶, 荒木博陽, 柴田和彦, 五味田裕, 光延文裕, 谷崎勝朗

    岡山大学三朝医療センター研究報告   2004

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  • 温泉療法が腰痛症患者のQOLに及ぼす効果

    横井正, 千田益生, 濱田全紀, 光延文裕, 保崎泰弘, 芦田耕三, 岩垣尚史, 永田拓也, 藤井誠, 高田真吾, 谷崎勝朗, 井上一

    岡山大学三朝医療センター研究報告   2004

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  • 呼吸器疾患の温泉療法 22年間の入院症例2298例を対象に

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三, 岩垣尚史, 永田拓也, 藤井誠, 高田真吾, 横井正, 濱田全紀

    岡山大学三朝医療センター研究報告   2004

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  • Spa therapy for bronchial asthma: Studies at the Misasa Medical Center

    Khai Vu, Fumihiro Mitsunobu

    Alternative and Complementary Therapies   10 ( 3 )   144 - 150   2004

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    Language:English   Publishing type:Book review, literature introduction, etc.   Publisher:Mary Ann Liebert Inc.  

    DOI: 10.1089/1076280041138243

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  • Spa therapy for bronchial asthma: Studies at the Misasa Medical Center

    Khai Vu, Fumihiro Mitsunobu

    Alternative and Complementary Therapies   10 ( 3 )   144 - 150   2004

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    DOI: 10.1089/1076280041138243

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  • 気管支喘息における温泉療法による薬剤費の削減の臨床的検討ー投与方法による検討

    芦田耕三, 光延文裕, 保崎泰弘, 濱田全紀, 岩垣尚史, 藤井誠, 高田真吾, 谷崎勝朗

    岡山大学三朝医療センター研究報告   2004

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  • 呼吸器疾患の温泉療法ー1982年から2004年までの23年間の入院症例2485例を対象にー

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三, 濱田全紀, 岩垣尚史, 藤井誠, 高田真吾

    岡山大学三朝医療センター研究報告   2004

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  • IgE-mediated allergy and cigarette smoking enhance the generation of leukotrienes B4(LTB4) and C4(LTC4) by leucocytes and bronchial hyperresponsiveness in pations with atopic asthma.

    Ashida K, Mitsunobu F, Hosaki Y, Iwagaki N, Nagata N, Fujii M, Takata S, Yokoi T, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ. Med Dent Sch   2004

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  • Difference in low attenuation area(LAA) of the lungs on high resolution computed tomography(HRCT)between asthma and pulmonary emphysema in relation to cigarette smoking.

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, nagata T, Fujii M, Takata S, Yokoi T, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ. Med Dent Sch.   2004

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  • 呼吸器疾患に対する温泉療法ーその臨床効果と作用機序ー

    光延文裕, 保崎泰弘, 芦田耕三, 濱田全紀, 山岡聖典, 谷崎勝朗

    岡山大学三朝医療センター研究報告   75:61-73   2004

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  • Cigarette smoking and pathophysiology of asthma and pulmonary emphysema.

    Ashida K, Mitsunobu F, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med. Center Okayama Univ   75,74-87   2004

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  • 【成人喘息の多様性】喘息病態の多様性 喘息病態における加齢の影響

    谷崎勝朗, 光延文裕

    喘息   17(2):43-46   2004

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  • 【COPDの薬物療法の最新の話題】吸入ステロイド薬 ベクロメタゾン・ブデソニドの比較

    光延文裕, 谷崎勝朗

    日本胸部臨床   63(2):144-150   2004

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  • レーザードプラー血流計による高齢者の末梢循環の数量的解析

    保崎泰弘, 光延文裕, 芦田耕三, 柘野浩史, 西田典数, 永田拓也, 高田真吾, 横井正, 谷崎勝朗, 越智浩二, 福田哲也, 白鳥康史

    岡大三朝医療センター研究報告   2003

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  • 呼吸器疾患の温泉療法-21年間の入院症例2129例を対象に-

    谷崎勝朗, 光延文裕, 保﨑泰弘, 芦田耕三, 西田典数, 柘野浩史, 永田拓也, 横井正, 高田真吾

    岡大三朝医療センター研究報告   2003

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  • Effects of spa therapy combined with dietary supplementation with α-linolenic acids on bronchial asthma.

    Okamoto M, Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • Airflow, the volume and transfer factor of lungs in elderly asthmatics with ling-term cigarette smoking.

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • BNPの著明な高値が持続した高齢者陳旧性心筋梗塞患者(高齢者のBNPについての考察も加えて)

    西田典数, 芦田耕三, 光延文裕, 保崎泰弘, 柘野浩史, 岡本誠, 永田拓也, 高田真吾, 横井正, 中井睦郎, 槙野博史, 谷崎勝朗

    岡大三朝医療センター研究報告   2003

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  • Effect of aging on the pathophysiology of asthma observed by IgE-mediated allergy, pulmonary function,low attenuation area of the lungs on HRCT, and LTB4,LTC4 generation.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • An increase in bronchial hyperresponsiveness by cigarette smoking in elderly patients with asthma.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • Long-term cigarette smoking influences low attenuation area of the lungs on high-resolution CT in elderly patients with asthma, compared with pulmonary emphysema.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • Infiuence of long-term cigarette smoking on changes of lung density by high-resolution computed tomography in asthmatics-4 years follow-up study-.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Nakai M, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • 高齢者気管支喘息の病態に及ぼす加齢及び喫煙の影響について(2)

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 永田拓也, 高田真吾, 横井正

    岡大三朝医療センター研究報告   73,93-101   2003

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  • 高齢者の内科診療 アレルギー・膠原病 高齢者気管支喘息の病態と治療

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三

    日本内科学会雑誌   92(3),448-452   2003

  • 気管支喘息に対する温泉療法

    光延文裕, 谷崎勝朗

    日本医事新報   4,116,105   2003

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  • 呼吸器疾患症例における温泉療法の効果 アンケートを利用して

    寺崎佳代, 山本貞枝, 吉尾慶子, 西村伸子, 光延文裕, 谷崎勝朗

    岡大三朝医療センター研究報告   2003

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  • 温泉療法が骨関節症患者のQOLに及ぼす効果

    横井正, 千田益生, 光延文裕, 保崎泰弘, 芦田耕三, 西田典数, 柘野浩史, 永田拓也, 高田真吾, 谷崎勝朗, 井上一

    岡大三朝医療センター研究報告   2003

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  • 【COPD(慢性閉塞性肺疾患)の治療】 COPDをめぐる臨床エビデンス 経口及び吸入ステロイド薬はCOPD患者の予後を改善するか

    光延文裕, 谷崎勝朗

    EBMジャーナル   4(4),446-450   2003

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  • 早期診断にて軽快したMPO-ANCA関連血管炎の一例

    市川裕久, 芦田耕三, 小野勝一郎, 高田真吾, 横井正, 永田拓也, 岡本誠, 柘野浩史, 西田典数, 保崎泰弘, 光延文裕, 谷崎勝朗, 野口善範, 谷本光音

    岡大三朝医療センター研究報告   2003

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  • Bromocriptineにより白血球減少症及び血小板減少症をきたしたパーキンソン病の1例

    高田真吾, 御舩尚志, 光延文裕, 岡本誠, 西田典数, 柘野浩史, 芦田耕三, 保崎泰弘, 横井正, 谷崎勝朗, 新谷憲治, 谷本光音

    岡大三朝医療センター研究報告   2003

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  • Yawning associated with anterior chest pain in a patient with asthma

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003

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  • 高齢者気管支喘息の病態におよぼす加齢および喫煙の影響について

    光延 文裕, 保崎 泰弘, 芦田 耕三, 柘野 浩史, 岡本 誠, 西田 典数, 横井 正, 高田 真吾, 谷崎 勝朗

    岡大三朝分院研究報告   ( 72 )   74 - 79   2002.2

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    Language:Japanese   Publisher:岡山大学医学部附属病院三朝医療センター  

    高齢者喘息の病態に対する加齢および喫煙の影響について,若干の検討を加えた。高齢者喘息,特に70才以上の喘息では,HRCT上の1950HU以下の肺のlow attenuation area(LAA)は,苦青年者喘息と比べ有意に増加していた.また,同時にこの年齢層では残気量の有意の増加,拡散能の有意の低下が見られた.% LAAと% 1秒量との間には,喘息の非喫煙例,喫煙例,肺気腫(全例喫煙例),いずれにおいても相関が見られた。しかし,% LAAと拡散能との間には,喘息の喫煙例および肺気腫では相関が見られたが,非喫煙例では有意の相関は見られなかった。これは,喫煙の拡散能におよぽす影響が大きいことを示唆しているものと考えられた。

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  • 体表面血流量の評価(その6) 末梢循環障害の非侵襲的早期診断と治療効果(2)

    保崎泰弘, 光延文裕, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 高田真吾, 横井正, 谷崎勝朗

    血栓と循環   2002

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  • Effects of aging on bronchoalveolar lavage(BAL) cells in patients with asthma.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi Y, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • 腰痛症患者における腰椎MRI画像所見の検討

    高田真吾, 横井正, 西田典数, 岡本誠, 柘野浩史, 芦田耕三, 保﨑泰弘, 御舩尚志, 光延文裕, 谷崎勝朗, 新谷憲治, 谷本光音

    岡大三朝分院研究報告   2002

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  • 男性ステロイド依存性喘息患者に対する4年間のエチドロネート投与の経験.

    柘野浩史, 岡本誠, 高田真吾, 横井正, 西田典数, 芦田耕三, 保崎泰弘, 光延文裕, 谷崎勝朗, 中井睦郎, 穐山恒雄, 長谷川寿一, 辻孝夫

    岡大三朝分院研究報告   2002

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  • 解離性大動脈瘤と冠動脈狭窄病変のマルチスライス(多列検出器型高速)CT画像診断(解離性上行大動脈瘤と狭心症を合併した一患者の診断と考察を元に)

    西田典数, 芦田耕三, 光延文裕, 保﨑泰弘, 柘野浩史, 岡本誠, 高田真吾, 横井正, 中井睦郎, 槇野博史, 谷崎勝朗

    岡大三朝分院研究報告   2002

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  • 呼吸器疾患に対する温泉療法―最近20年間の入院症例1934例を対象にー

    谷崎勝朗, 光延文裕, 保﨑泰弘, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 高田真吾, 横井正

    岡大三朝分院研究報告   2002

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  • RA患者のQOL -SF-36を用いて-

    横井正, 千田益生, 光延文裕, 保崎泰弘, 芦田耕三, 西田典数, 柘野浩史, 岡本誠, 高田真吾, 谷崎勝朗, 井上 一

    岡大三朝分院研究報告   2002

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  • The role of leukotrienes B4 (LTB4) and C4(LTC4) in pathophysiology of asthma in the elderly.Relationship to bronchial hyperresponsiveness and FEV1.0%.

    Mitusnobu F, Hosaki, Ashida K, Tsugeno H, Okamoto M, Nshida N, Takata S, Yokoi T, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • Effects of α-linolenic acid-rich supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism

    Okamoto M, Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Yokoi T, Takata S, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • The generation of leukotrienes B4(LTB4) and C4(LTC4) and bronchial hyperresponsiveness in patients with asthma and spa therapy

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • Non-invasive study for peripheral circulation in patients with diabetes mellitus

    Hosaki Y, Mitusnobu F, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Tanizaki Y, Ochi K, Tsuji T

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • %Low attenuation area (%LAA) of the lungs on high resolution computed tomography (HRCT),associated with pulmonary function in elderly patients with asthma.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi Y, Nakai M, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002

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  • 温泉医学・将来の展望―温泉を利用した疾患の治療 ⑤ 吸器疾患

    光延文裕, 谷崎勝朗

    日温気物医誌   2002

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  • 多価不飽和脂肪酸と免疫機能

    岡本誠, 光延文裕, 芦田耕三, 谷崎勝朗

    臨床免疫   2002

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  • 気管支喘息

    谷崎勝朗, 光延文裕, 御舩尚志, 保崎泰弘, 芦田耕三

    Medicament News   2001

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  • 老年者の喘息

    谷崎勝朗, 御舩尚志, 光延文裕, 保崎泰弘, 芦田耕三

    医学と薬学   2001

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  • 気管支喘息・慢性気管支炎

    谷崎勝朗, 光延文裕

    臨床と研究   2001

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  • 呼吸器疾患

    光延文裕, 御舩尚志, 谷崎勝朗

    日温気物医誌   2001

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  • 肺外に起因する慢性咳嗽の病態とその対策

    谷崎勝朗, 御舩尚志, 光延文裕

    アレルギーの臨床   2001

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  • 喘息の治療;併用薬剤の注意点

    谷崎勝朗, 光延文裕, 御舩尚志

    臨床成人病   2001

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  • Effects of spa therapy on pulmonary emphysema in relation to IgE-mediated allergy

    MITSUNOBU F

    J Jpn Asoc Phys Med Balneol Climatol   63   120 - 126   2000

  • Association of the mean CT number by high resolution computed tomography (HRCT) with generation of leukotrienes B4 (LTB4) and C4 (LTC4) in patients with pulmonary emphysema.

    F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, M Okamoto, S Harada, S Takata, Y Tanizaki

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   159 ( 3 )   A816 - A816   1999.3

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:AMER LUNG ASSOC  

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  • Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years

    ( 69 )   1 - 8   1998.12

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    Language:Japanese  

    The kind of respiratory disease, age, and areas where patients came from were analyzed in 511 patients with chronic obstructive pulmonary disease (COPD) admitted at Misasa Medical Branch for last 5 years from 1993 to 1997. 1.For the last 5 years 594 patients with respiratory diseases were admitted at Misasa Medical Branch. Of these patients 511 (86.0%) were those with COPD. Of the 511, 416 (81.4%) were patients with asthma, 20 with chronic bronchitis, 27 with obstructive bronchiolitis, and 48 with pulmonary emphysema. 2.The number of patients with pulmonary emphysema showed a tendency to increase in recentyears. 3.Regarding the distribution of age of these patients, the number of patients over the age of 60 waslarger than the number of patients under the age of 59:patients between the ages of 60 and 69 were morefrequently observed in those coming from distant area(outside Tottori prefecture), and those over the age of70 in those coming from Tottori prefecture. 4. The number of patients from distant areas (outside Tottori prefecture) was considerably larger (48.4% in 1997)compared to the number of patients from Tottori prefecture. The number of patients from Okayama, Hyogo, Osaka, Hiroshima, Yamaguchi and Ehime was predominantly larger than the number of patients from other distant areas.

    CiNii Article

    CiNii Books

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  • Effects of spa therapy on patients with pulmonary emphysema. Relationship to disease severity evaluated by low attenuation area of the lung on high resolution computed tomography

    MITSUNOBU F

    J Jpn Assoc Phys Med Balneol Climatol   61   79 - 86   1998

  • Effects of spa therapy on asthmatics with low ventilatory function. Relationship to asthma type, patient age, and airway inflammation

    MITSUNOBU F

    J Jpn Assoc Phys Med Balneol Climatol   60   125 - 132   1997

  • Association of spa effects with generation of leukotrienes B4 and C4 by leucocytes in patients with asthma

    MITSUNOBU F

    J Jpn Assoc Phys Med Balneol Climatol   60   141 - 148   1997

  • Association of spa effects with generation of leukotrienes B4 and C4 in patients with asthma

    MITSUNOBU F

    J Jpn Assoc Phys Med Balneol Climatol   60   141 - 148   1997

  • 大腸前処置法の栄養評価としてのレチノール結合蛋白の有用性の検討

    加藤匡宏, 蓮岡英明, 越智浩二, 水島孝明, Chowdhury R, 松村直樹, 山本良一, 田中淳太郎, 原田英雄, 穐山恒雄, 横田聡, 光延文裕, 谷崎勝朗

    岡山大学三朝分院研究報告   67   71 - 74   1996.11

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  • Improvement of bronchial sensitivity by spa therapy in patients with asthma

    MITSUNOBU F

    J Jpn assoc Phys Med Balneol Climatol   58   241 - 248   1995

  • Sodium picosulfate, PEG腸管洗浄液併用によるTotal colonoscopyの前処置法に関する検討

    越智浩二, 原田英雄, Chowdhury Riaz, 田中淳太郎, 松本秀次, 妹尾敏伸, 水島孝明, 光延文裕, 谷崎勝朗:穐山恒雄, 中井睦郎, 蓮岡英明, 加藤匡宏

    岡山大学三朝分院研究報告   65   22 - 26   1994.9

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  • The oncogenicity of jun. International journal

    P K Vogt, T J Bos, F Mitsunobu, T Nishimura, F S Monteclaro, H Y Su

    Princess Takamatsu symposia   20   127 - 34   1989

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    The oncogenic transforming potential of the jun oncogene was investigated with viral constructs that contain various terminal deletions of v-jun, c-jun and recombinants between the viral and cellular genes. Cellular jun can induce transformation of chicken embryo fibroblasts with a low efficiency. High efficiency transformation is dependent on alterations in the major transactivator domain. A jun deletion that lacks the transactivator domain is non-transforming. These observations are compatible with the conclusion that transcriptional regulation plays an important part in jun oncogenesis. In cells transformed by viral jun and expressing high levels of viral jun expression of the cellular jun is not constitutively upregulated. Cellular jun may therefore not contribute to transformation in these cells.

    PubMed

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Presentations

  • 正常マウスとリウマチマウスではラドン吸入によるサイトカイン代謝に及ぼす影響は異なる

    直江 翔太, 片岡 隆浩, 村上 海斗, 雪峰 諒平, 藤本 有希, 神﨑 訓枝, 迫田 晃弘, 光延 文裕, 山岡 聖典

    日本原子力学会中国・四国支部第15回研究発表会  2021.10.30 

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    Event date: 2021.10.30

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン吸入によるマウス諸臓器中のレドックス状態の変化特性とDNA酸化損傷の抑制効果の検討

    片岡 隆浩, 首藤 妃奈, 直江 翔太, 矢野 準喜, 神﨑 訓枝, 迫田 晃弘, 田中 裕史, 花元 克巳, 光延 文裕, 寺東 宏明, 山岡 聖典

    日本原子力学会中国・四国支部第15回研究発表会  2021.10.30 

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    Event date: 2021.10.30

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン吸入はマウス脳・腎臓・小腸のDNA酸化損傷を抑制する

    片岡 隆浩, 首藤 妃奈, 直江 翔太, 矢野 準喜, 神﨑 訓枝, 迫田 晃弘, 田中 裕史, 花元 克巳, 光延 文裕, 寺東 宏明, 山岡 聖典

    日本放射線影響学会第64回大会  2021.9 

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    Event date: 2021.9.22 - 2021.9.24

    Language:Japanese   Presentation type:Poster presentation  

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  • ラドン吸入がマウス血液中のサイトカイン代謝に及ぼす効果に関する基礎研究

    直江 翔太, 片岡 隆浩, 藤本 有希, 村上 海斗, 雪峰 諒平, 神﨑 訓枝, 迫田 晃弘, 光延 文裕, 山岡 聖典

    日本放射線影響学会第64回大会  2021.9 

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    Event date: 2021.9.22 - 2021.9.24

    Language:Japanese   Presentation type:Poster presentation  

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  • ラドン吸入によるマウス諸臓器中のDNA酸化損傷抑制の濃度依存性に関する検討

    増川 祐伎, 片岡 隆浩, 首藤 妃奈, 直江 翔太, 矢野 凖喜, 神﨑 訓枝, 迫田 晃弘, 田中 裕史, 花元 克巳, 光延 文裕, 寺東 宏明, 山岡 聖典

    第58回アイソトープ・放射線研究発表会  2021.7 

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    Event date: 2021.7.7 - 2021.7.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

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  • トロン吸入とアスコルビン酸投与による急性アルコール性マウス肝障害の抑制効果に関する検討

    西 微香, 片岡 隆浩, 石田 毅, 直江 翔太, 首藤 妃奈, 矢野 凖喜, 神﨑 訓枝, 迫田 晃弘, 田中 裕史, 光延 文裕, 山岡 聖典

    第58回アイソトープ・放射線研究発表会  2021.7 

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    Event date: 2021.7.7 - 2021.7.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

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  • ラドン吸入によるDNA酸化損傷の抑制効果に関する検討

    片岡 隆浩, 神﨑 訓枝, 迫田 晃弘, 首藤 妃奈, 矢野 準喜, 直江 翔太, 田中 裕史, 花元 克巳, 寺東 宏明, 光延 文裕, 山岡 聖典

    第74回⽇本酸化ストレス学会/第21回⽇本NO学会 合同学術集会  2021.5 

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    Event date: 2021.5.19 - 2021.5.20

    Language:Japanese   Presentation type:Poster presentation  

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  • Alteration of redox state following radon inhalation depends on the antioxidant capacity of organs International conference

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    The 20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021)  2021.3 

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    Event date: 2021.3.15 - 2021.3.18

    Language:English   Presentation type:Oral presentation (general)  

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  • ラドン吸入による諸臓器中のレドックス状態の変化特性に関する比較検討

    矢野 準喜, 片岡 隆浩, 神崎訓枝, 迫田 晃弘, 首藤 妃奈, 直江 翔太, 田中 裕史, 花元 克巳, 寺東 宏明, 光延 文裕, 山岡 聖典

    日本原子力学会中国・四国支部第14回研究発表会  2020.12.12  日本原子力学会中国・四国支部

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    Event date: 2020.12.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

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  • Evaluation of redox status in various organs of mice by radon inhalation

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    The 63rd Annual Meeting of the Japanese Radiation Research Society  2020.10 

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    Event date: 2020.10.15 - 2020.10.17

    Language:Japanese   Presentation type:Poster presentation  

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  • Skin surface deposition of radon progeny and its resulting dose

    Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

    The 63rd Annual Meeting of the Japanese Radiation Research Society  2020.10 

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    Event date: 2020.10.15 - 2020.10.17

    Language:Japanese   Presentation type:Poster presentation  

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  • Basic study on the effect of radon inhalation on edema of mouse limbs

    Junki Yano, Takahiro Kataoka, Hina Shuto, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

    The 63rd Annual Meeting of the Japanese Radiation Research Society 

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    Event date: 2020.10.15 - 2020.10.17

    Language:Japanese   Presentation type:Poster presentation  

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  • Effects of radon inhalation on oxidative stress in mouse brain and liver.

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    2020.10 

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    Event date: 2020.10.6 - 2020.10.7

    Language:Japanese   Presentation type:Poster presentation  

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  • Differences in redox status in mice organs affect the activation of antioxidative functions by radon inhalation

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Atomic Energy Society of Japan Autumn Annual Meeting 2020  2020.9 

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    Event date: 2020.9.16 - 2020.9.18

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 主成分分析を用いたラドン吸入によるマウス諸臓器中の酸化ストレスの評価

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    2020.8.7 

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    Event date: 2020.8.7

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Radon inhalation time dependent changes in the hydrogen peroxide production in mice organs

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Tsuyoshi Ishida, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    Atomic Energy Society of Japan Spring Annual Meeting 2020  2020.3 

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    Event date: 2020.3.16 - 2020.3.19

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Evaluation of hydrogen peroxide induced oxidative stress by radon inhalation in mouse organs

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Tsuyoshi Ishida, Hina Shuto, Junki Yano, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    The 62nd Annual Meeting of the Japanese Radiation Research Society  2019.11 

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    Event date: 2019.11.14 - 2019.11.16

    Language:Japanese   Presentation type:Poster presentation  

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  • ラドン吸入による抗酸化機能の亢進がマウス諸臓器中の過酸化水素産生に及ぼす作用

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Tsuyoshi Ishida, Hina Shuto, Junki Yano, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    2019.9.20 

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    Event date: 2019.9.20

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン吸入によるマウス諸臓器中の過酸化水素産生に関する基礎的検討

    Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Tsuyoshi Ishida, Hina Shuto, Junki Yano, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

    2019.8.2 

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    Event date: 2019.8.2

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン水の皮脂成分への溶解度とその温度依存性に関する検討

    Tsuyoshi Ishida, Akihiro Sakoda, Takahiro Kataoka, Norie Kanzaki, Hiroshi Tanaka, Hayato Yunoki, Fumihiro Mitsunobu, Kiyonori Yamaoka

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    Event date: 2019.7.3 - 2019.7.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Frailty: The Status of Frailty in Our Hospital - Potential Utilization of Hot Springs Invited

    Kozo Ashida, Yasuo Morio, Fumihiro Mitsunobu

    The 84th Annual Meeting of the Japanese Society of Balneology, Climatology and Physical Medicine (BCPM)  2019.5.19 

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    Event date: 2019.5.18 - 2019.5.19

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • The role of balneology, climatology and physical medicine in the medical care for the elderly Invited

    Fumihiro Mitsunobu

    The 84th Annual Meeting of the Japanese Society of Balneology, Climatology and Physical Medicine (BCPM)  2019.5.18 

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    Event date: 2019.5.18 - 2019.5.19

    Language:Japanese   Presentation type:Oral presentation (keynote)  

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  • ラドン水の皮膚への作用に関する検討ー皮脂諸成分への溶解度とその温度依存性ー

    石田 毅, 迫田 晃弘, 片岡 隆浩, 神崎 訓枝, 田中 裕史, 柚木 勇人, 石森 有, 光延 文裕, 山岡 聖典

    日本原子力学会中国・四国支部第12回研究発表会  2018.11.17  一般社団法人日本原子力学会 中国・四国支部

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    Event date: 2018.11.17

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福山大学 宮地茂記念館(広島県 福山市)  

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  • ラドンの皮脂成分での溶解特性

    石田 毅, 迫田 晃弘, 片岡 隆浩, 神崎 訓枝, 田中 裕史, 小橋 佑介, 柚木 勇人, 石森 有, 光延 文裕, 山岡 聖典

    日本放射線影響学会第61回大会  2018  一般社団法人日本放射線影響学会

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    Event date: 2018.11.7 - 2018.11.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎県 長崎市 長崎ブリックホール  

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  • Comparative study on oxidative stress mitigation effect in mouse organs by inhalation of radon and thoron

    2018 

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    Event date: 2018.9.5 - 2018.9.7

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Treatment results and research trends of radon therapy

    Fumihiro Mitsunobu

    2018 

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    Event date: 2018.9.5 - 2018.9.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Basic study on the effects of radon water on skin. Solubility in sebum

    2018 

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    Event date: 2018.9.5 - 2018.9.7

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン水の皮膚に及ぼす影響の基礎的検討?皮脂成分への溶解特性?

    「石田 毅」「迫田 晃弘」「片岡 隆浩」「神? 訓枝」「田中 裕史」「小橋 佑介」「柚木 勇人」「石森 有」「光延 文裕」「山岡 聖典」

    第43回中国地区放射線影響研究会  中国地区放射線影響研究会

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    Event date: 2018.7.31

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島県 広島市 広島大学医学部 広仁会館  

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  • 呼吸器疾患と温泉入浴

    「光延 文裕」

    第39回温泉療法医教育研修会  日本温泉気候物理医学会

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    Event date: 2018.5.19 - 2018.5.20

    Language:Japanese  

    Venue:鹿児島県 鹿児島市 かごしま県民交流センター  

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  • The comparison of antioxidative effects of radon and thoron inhalation on mouse brain. International conference

    The 8th Annual Meeting of the International Society of Radiation Neurobiology  2018 

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    Event date: 2018.2.9 - 2018.2.10

    Language:English   Presentation type:Oral presentation (general)  

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  • Future direction of medical and nursing care in super-aged society International conference

    Fumihiro Mitsunobu

    the 46th Myanmar Health Research Congress  2018  Ministry of Health and Sports, the Republic of the Union of Myanmar

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    Event date: 2018.1.8 - 2018.1.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Ministry of Health and Sports, Yangon, Myanmar  

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  • ラドンとトロンの吸入による生物学的効果に関する比較検討?小動物用トロン吸入装置の試作と抗酸化機能の比較?

    「小橋 佑介」「片岡 隆浩」「神崎 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「山岡 聖典」

    日本放射線影響学会第60回大会  一般社団法人日本放射線影響学会

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    Event date: 2017.10.25 - 2017.10.28

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉県千葉市 京葉銀行文化プラザ  

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  • 小動物用トロン吸入装置を用いたラドンとトロンの吸入効果比較の基礎的検討

    「小橋 佑介」「片岡 隆浩」「神? 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「山岡 聖典」

    低線量放射線健康影響研究会2017  2017  低線量放射線健康影響研究会

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    Event date: 2017.9.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山県岡山市(岡山大学鹿田キャンパス)  

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  • 小動物用トロン吸入装置の試作とこれを用いたラドンとトロンの吸入効果比較の基礎的検討

    「小橋 佑介」「片岡 隆浩」「神? 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「山岡 聖典」

    日本原子力学会 中国・四国支部 第11回研究発表会  2017  日本原子力学会 中国・四国支部

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    Event date: 2017.9.20

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛県松山市(四国電力(株)原子力保安研修所)  

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  • アルコール誘導マウス胃粘膜障害に対するラドンの吸入と飲泉による抑制効果の比較検討

    「石田 毅」「片岡 隆浩」「恵谷 玲央」「神? 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「田口 勇仁」「山岡 聖典」

    平成29年度若手放射線生物学研究会専門研究会  2017  若手放射線生物学研究会

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    Event date: 2017.9.2 - 2017.9.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都文京区 東京大学 アイソトープ総合センター  

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  • 慢性呼吸器疾患に対する温熱療法

    光延 文裕

    平成29年度岡山呼吸器疾患研究会 第1回総会  2017  岡山呼吸器疾患研究会

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    Event date: 2017.8.26

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岡山  

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  • ラドンの吸入と飲泉の差異によるアルコール誘導マウス胃粘膜障害の抑制効果の比較検討

    「片岡 隆浩」「恵谷 玲央」「神? 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「田口 勇仁」「山岡 聖典」

    第54回アイソトープ・放射線研究発表会,  2017  公益社団法人 日本アイソトープ協会

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    Event date: 2017.7.5 - 2017.7.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • ラドンの吸入と飲泉によるアルコール誘導マウス胃粘膜障害の抑制作用の機序に関する比較検討

    「片岡 隆浩」「恵谷 玲央」「神? 訓枝」「迫田 晃弘」「田中 裕史」「石森 有」「光延 文裕」「田口 勇仁」「山岡 聖典」

    第70回日本酸化ストレス学会学術集会  2017  日本酸化ストレス学会

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    Event date: 2017.6.28 - 2017.6.29

    Language:Japanese   Presentation type:Poster presentation  

    Venue:つくば国際会議場,茨城県つくば市  

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  • COPDのリハビリテーション概論と和温療法

    光延 文裕

    第2回和温療法研修会  2017  和温療法研修センター

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    Event date: 2017.5.21

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

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  • Involvement of antioxidant function on suppressive effect of alcohol-induced mouse gastric mucosal injury by inhalation or drinking of radon

    2017 

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    Event date: 2017.3.27 - 2017.3.29

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • COPDのリハビリ概論と和温療法の効果

    光延文裕

    第1回和温療法研修会  2016  和温療法研修センター

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    Event date: 2016.11.27

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

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  • W1:ラドン温泉 低線量放射線の健康影響:ラドン温泉の健康効果とそのリスク W1-3 ラドン療法の臨床効果の実例と研究動向

    The 59th Annual Meeting of the Japanese Radiation Research Society  2016 

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    Event date: 2016.10.26 - 2016.10.28

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • ラドン療法条件の最適化に関する基礎的検討

    The 59th Annual Meeting of the Japanese Radiation Research Society  2016 

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    Event date: 2016.10.26 - 2016.10.28

    Language:Japanese   Presentation type:Poster presentation  

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  • ラドン温泉におけるアルコール誘導胃粘膜障害の抑制効果に関する検討

    「恵谷玲央」「片岡隆浩」「神?訓枝」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「田口勇仁」「山岡聖典」

    低線量放射線健康影響研究会2016  2016  低線量放射線健康影響研究会

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    Event date: 2016.9.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山  

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  • アルコール誘導マウス胃粘膜障害へのラドンの吸入と飲泉による抑制効果の組織・病理学的比較検討

    「石田 毅」「片岡隆浩」「恵谷玲央」「神?訓枝」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「田口勇仁」「山岡聖典」

    日本原子力学会中国・四国支部第10回研究発表会  2016  日本原子力学会中国・四国支部

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    Event date: 2016.9.16

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:坂出  

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  • Comparative study on the inhibitory effects of different types of radon treatment on oxidative damage in mice

    Takahiro Kataoka][Reo Etani][Norie Kanzaki][Kaori Sasaoka][Akihiro Sakoda][Hiroshi Tanaka][Yusuke Kobashi][Yuu Ishimori][Fumihiro Mitsunobu][Kiyonori Yamaoka

    2016 

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    Event date: 2016.9.7 - 2016.9.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ラドン療法の新規適応症に関する我々の研究動向

    「片岡隆浩」「神崎訓枝」「笹岡香織」「小橋佑介」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「山岡聖典」

    平成28年度若手放射線生物学研究会専門研究会  2016  若手放射線生物学研究会

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    Event date: 2016.9.3 - 2016.9.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • 三朝ラドン効果研究の意義と近年の研究動向

    「片岡隆浩」「神?訓枝」「笹岡香織」「小橋佑介」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「山岡聖典」

    第41回中国地区放射線影響研究会  2016  中国地区放射線影響研究会

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    Event date: 2016.7.26

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:放射線影響研究所(広島)  

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  • 水中運動の効果を評価し得る指標についての検討

    「加藤冠」「高野智子」「丸山和彦」「光延文裕」

    第81回日本温泉気候物理医学会総会・学術集会  2016  日本温泉気候物理医学会

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    Event date: 2016.5.14 - 2016.5.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬県渋川市伊香保温泉  

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  • 鉱泥浴槽中の細菌数の変化と殺菌法の検討

    「山成俊夫」「芦田耕三」「光延文裕「森尾泰夫」

    第81回日本温泉気候物理医学会総会・学術集会  2016  日本温泉気候物理医学会

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    Event date: 2016.5.14 - 2016.5.15

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬県渋川市伊香保温泉  

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  • ラドン温泉における吸入または飲泉による高尿酸血症の抑制効果の比較検討 International conference

    恵谷玲央, 片岡隆浩, 神?訓枝, 迫田晃弘, 田中裕史, 石森 有, 光延文裕, 山岡聖典

    日本放射線影響学会 第1回放射線ワークショップ~未来に繋ぐ放射線研究~  2015.10  日本放射線影響学会

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    Event date: 2015.10.16 - 2105.10.17

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:富山大学五福キャンパス 黒田講堂(富山県)  

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  • ラドン温泉における高尿酸血症の抑制効果に関する検討

    「恵谷玲央」「片岡隆浩」「神?訓枝」「迫田晃弘」「田中裕史」「石森有」「光延文裕」「山岡聖典」

    日本原子力学会 中国・四国支部 第9回研究発表会  2015  日本原子力学会 中国・四国支部

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    Event date: 2015.9.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口県宇部市  

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  • ラドン温泉の飲泉がオキソン酸誘導マウス高尿酸血症に及ぼす効果の検討 International conference

    「恵谷玲央」「片岡隆浩」「神崎訓枝」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「山岡聖典」

    平成27年度 若手放射線生物学研究会 専門研究会  2015  若手放射線生物学研究会

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    Event date: 2015.8.8 - 2015.8.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • ラドン吸入によるXOD活性の減少は尿酸値の増加を抑制する

    「恵谷玲央」「片岡隆浩」「神崎訓枝」「中田哲也」「迫田晃弘」「田中裕史」「石森 有」「光延文裕」「山岡聖典」

    第52回アイソトープ・放射線研究発表会  2015  日本アイソトープ協会

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    Event date: 2015.7.8 - 2015.7.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学弥生講堂(東京都)  

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  • 東京在住の喘息患者に対する温泉療法の効果と課題

    「加藤冠」「高野智子」「丸山和彦」「光延文裕」「森山俊男」

    第80回日本温泉気候物理医学会総会・学術集会  2015  日本温泉気候物理医学会

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    Event date: 2015.6.20 - 2015.6.21

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢プリンスホテル・ウエスト(長野県軽井沢町)  

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  • ラドン吸入によるマウス脳中SOD活性の増加とその機構に関する考察

    「片岡 隆浩」「恵谷 玲央」「神崎 訓枝」「小橋 佑介」「迫田 晃弘」「石森 有」「光延 文裕」「山岡 聖典」

    第68回日本酸化ストレス学会学術集会  2015  日本酸化ストレス学会学術集会

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    Event date: 2015.6.11 - 2015.6.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:かごしま県民交流センター(鹿児島県鹿児島市)  

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  • Measurements of radon concentration in mouse blood following radon inhalation International conference

    「Yuu Ishimori」「Hiroshi Tanaka」「Akihiro Sakoda」「Takahiro Kataoka」「Kiyonori Yamaoka」「Fumihiro Mitsunobu」

    15th International Congress of Radiation Research  2015  International Congress of Radiation Research

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    Event date: 2015.5.25 - 2015.5.29

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kyoto International Conference Center(Kyoto)  

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  • ラドン吸入によるCCl4 誘導マウス肝障害の抑制効果とその医療応用の可能性 International conference

    「片岡隆浩」「西山祐一」「恵谷玲央」「高田裕司」「豊田晃章」「迫田晃弘」「石森有」「光延 文裕」「田口勇仁」「山岡聖典」

    第66 回日本酸化ストレス学会学術集会  2013  日本酸化ストレス学会

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    Event date: 2013.6.13 - 2013.6.14

    Language:Chinese   Presentation type:Poster presentation  

    Venue:ウインク愛知(名古屋市)  

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  • ラドン水の皮膚に及ぼす影響の基礎的検討-皮脂成分への溶解特性-

    第43回中国地区放射線影響研究会  2018 

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  • ラドン水の皮膚に及ぼす影響の基礎的検討 皮脂への溶解度

    日本原子力学会2018秋の大会  2018 

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  • ラドンの吸入または飲泉によるアルコール誘導マウス胃粘膜障害の抑制効果における抗酸化機能の関与

    日本原子力学会2017年春の年会  2017 

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  • ラドンとトロンの吸入による生物学的効果に関する比較検討―小動物用トロン吸入装置の試作と抗酸化機能の比較―

    日本放射線影響学会第60回大会  2017 

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  • マウス酸化障害抑制に及ぼすラドン各種摂取方法の比較検討

    日本原子力学会「2016年秋の大会」  2016 

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  • ラドン吸入がオキソン酸誘導マウス高尿酸血症に及ぼす効果の検討

    平成27年 若手放射線生物学研究会 第5回勉強会  2015 

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  • 三朝温泉と温泉療法

    日本温泉科学会第67回大会  2014 

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  • ラドン温泉において糖尿病の抑制に吸入と飲泉はどちらが有効か

    第67回日本酸化ストレス学会学術集会  2014 

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  • ラドン含有の吸入または飲泉がマウス糖尿病に及ぼす効果

    平成26年度 京都大学原子炉実験所専門研究会  2014 

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  • Effects of bathing containing artificial carbon dioxide and sodium chloride on several different symptoms: different of acute and chronic effects

    39th \World Congress of International Society of Medical Hydrology and Climatology  2014 

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  • Effects of radon inhalation on oxidative damage and possibility of clinical application for lifestyle diseases

    39th \World Congress of International Society of Medical Hydrology and Climatology  2014 

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  • ラドン含有の吸入と飲泉によるマウス1型糖尿病の抑制効果の比較検討

    日本放射線影響学会第57回大会  2014 

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  • ラドン吸入によるSOD の活性増加の濃度・吸入時間依存性およびその局在に関する検討

    日本原子力学会中国・四国支部 第8回研究発表会  2014 

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  • ラドン吸入によるマウス肝障害の抑制効果とその医療応用の可能性

    日本放射線影響学会第56回大会  2013 

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  • ラドン吸入試験におけるマウスの線量評価

    第46回日本保健物理学会研究発表会  2013 

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  • 東京の温泉療法医の役割について―都心に在住する患者に対する取り組みを通して(第3報)―

    第78回日本温泉気候物理医学会総会・学術集会  2013 

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  • Dose Assessment for Mice in the Radon Exposure Experiment

    2013 

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  • 高齢者の慢性疼痛性疾患に対する薬物療法

    第25回日本老年医学会中国地方会  2013 

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  • ラドン雰囲気におけるマウスの臓器吸収線量系統的検討

    日本放射線影響学会第56回大会  2013 

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  • The culture of hot spring wellness in Japan.

    Taipei Hot Spring Festival  2009 

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  • “Hot Spring Relate to Health ”.

    Taipei Hot Spring Festival  2009 

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  • “Overview of Evidence Based Medicine in Balneology Study”.

    Taipei Hot Spring Festival  2009 

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  • 水中運動の効果を評価し得る指標についての検討―東京の温泉療法医としての活動を通して

    第73回日本温泉気候物理医学会総会・学術集会  2008 

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  • 後期高齢者市中肺炎の予後因子に関する臨床的検討

    第104回日本内科学会講演会  2008 

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  • 高齢者市中肺炎の臨床的研究―非高齢者、前期高齢者と後期高齢者の比較検討―

    第20回日本老年医学会中国地方会  2008 

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  • COPD患者の運動耐用能・肺機能に対する温熱療法の有用性についての検討

    第48回日本呼吸器学会学術講演会  2008 

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  • 長期吸入療法患者に対する吸入薬再指導の有用性について

    第20回日本アレルギー学会春季臨床大会 2008.6.13  2008 

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  • 腹水が自然軽快を示し、脳結核腫、脊椎カリエスを合併した結核性腹膜炎の1例

    第98回日本内科学会中国地方会  2008 

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  • 食塩含有人工炭酸泉浴の各種症状に及ぼす治療効果について(その2):主観的治療効果と血流量の増加との関連について

    第73回日本温泉気候物理医学会総会・学術集会  2008 

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  • 慢性閉塞性肺疾患患者の運動耐容能に対する温泉療法の有効性の検討

    平成20年度鳥取県医師会秋季医学会  2008 

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  • 呼吸器疾患のリハビリテーション―慢性閉塞性肺疾患(COPD)と気管支喘息を中心に―

    平成20年度鳥取県医師会秋季医学会  2008 

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  • 運動耐用能・肺機能の改善に温熱療法が有効と考えられたCOPD患者の一例

    第43回日本呼吸器学会中国四国地方会  2008 

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  • 後期高齢者市中肺炎の臨床的検討―生存群と死亡群の比較検討―

    第50回日本老年医学会学術集会  2008 

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  • 肝機能異常を契機に発見されたサルコイドーシスの1例

    第99回日本内科学会中国地方会  2008 

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  • 食塩含有人工炭酸泉浴の各種症状に及ぼす治療効果について(その1):急性および慢性効果の相違について

    第73回日本温泉気候物理医学会総会・学術集会  2008 

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  • 鉱泥湿布による生体への有効性の調査研究

    第22回日本リハビリテーション医学会中国・四国地方会  2008 

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  • アトピー性皮膚炎患者におけるn-3系不飽和脂肪酸(PUFA)強化食の有効性についての検討

    第58回日本アレルギー学会秋季学術大会  2008 

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  • 人工炭酸泉浴(バブ浴)を用いた足浴の下肢末梢循環に及ぼす影響について(その2)

    第72回日本温泉気候物理医学会総会・学術集会  2007 

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  • 当院における市中肺炎入院炎症の臨床的検討

    第47回日本呼吸器学会学術講演会  2007 

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  • 慢性好酸球性肺炎の2例

    第19回日本アレルギー学会春季臨床大会号  2007 

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  • 健常成人に発症したサイトメガロウイルス関連胃病変の1例

    日本内科学会中国地方会  2007 

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  • 東京都心に存在する患者に対する温泉療法の今後の課題-東京の温泉療法医としての活動を通して

    第72回日本温泉気候物理医学会総会・学術集会  2007 

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  • 温泉療法が慢性閉塞性肺疾患(COPD)患者の運動耐溶能に及ぼす影響に関する検討

    第72回日本温泉気候物理医学会総会・学術集会  2007 

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  • 慢性閉塞性肺疾患患者における6分間歩行試験に対する温泉療法の有用性の検討

    日本呼吸器学会中国四国地方会  2007 

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  • 温泉療法が慢性疾患患者の健康関連QOLに及ぼす影響に関する検討

    第71回日本温泉気候物理医学会総会・学術集会  2006 

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  • 気管支喘息に対するn-3系不飽和脂肪酸強化食の有効性

    第103回日本内科学会講演会  2006 

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  • 慢性呼吸器疾患患者に対する当院の運動浴および温熱治療を中心としたリハビリテーション医療の治療効果に関する検討

    第46回日本呼吸器学会学術講演会  2006 

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  • 胃癌切除後に発症した顕微鏡的多発血管炎の1例

    第18回日本アレルギー学会春季臨床大会号  2006 

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  • 人工炭酸泉浴(バブ浴)を用いた足浴の下肢末梢循環に及ぼす影響について

    第71回日本温泉気候物理医学会総会・学術集会  2006 

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  • 東京都心に存在する患者に対する温泉療法について

    第71回日本温泉気候物理医学会総会・学術集会  2006 

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  • アルコール性肝障害として経過観察中80歳代にて発見された原発性胆汁性肝硬変の1例

    第18回日本老年学会中国地方会  2006 

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  • 薬物(sofalcone)の高齢者胃粘膜血流量に及ぼす影響の定量的観察

    第48回日本老年医学会学術集会・総会  2006 

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  • 高齢慢性疾患患者の健康関連のQOLに対する温泉療法の有効性に関する検討

    第48回日本老年医学会学術集会・総会  2006 

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  • 肝細胞癌の経過中に肝原発腺扁平上皮癌を合併した1例

    第94回 日本内科学会中国地方会  2006 

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  • 気管支喘息患者に対するn-3系不飽和脂肪酸強化食の血清ECP値に及ぼす影響

    第56回日本アレルギー学会秋季学術大会号  2006 

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  • 髄膜炎を契機に発見された進行大腸癌の1例

    第92回日本内科学会中国地方会  2005 

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  • 気管支喘息における長期間喫煙による病態的変化の若年者と高齢者の比較

    第17回日本アレルギー学会春季臨床大会 2005.6.4(岡山)  2005 

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  • 温泉療法による気管支喘息における肺の過膨張に対する改善作用―喫煙症例と非喫煙症例の比較検討―

    第70回日本温泉気候物理医学会総会 2005.5.27(冨山)  2005 

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  • 高齢気管支喘息患者に対する温泉療法の臨床効果に対する長期間喫煙の影響

    第45回日本呼吸器学会  2005 

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  • 気管支喘息に対する食事療法―8週間のn-3系不飽和脂肪酸強化食による検討―

    第45回日本呼吸器学会  2005 

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  • 気管支喘息における肺の過膨張に対する温泉療法の改善効果についての検討

    第102回日本内科学会講演会  2005 

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  • ケトプロフェン湿布剤により全身性麻疹様紅斑をきたした1例

    第17回日本アレルギー学会春季臨床大会  2005 

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  • 重症アトピー性皮膚炎患者に対し当院の温泉療法が有効であった3例

    第17回日本アレルギー学会春季臨床大会  2005 

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  • 東京都心に在住する患者に対する温泉療法について―東京の温泉療法医の果たす役割

    第70回日本温泉気候物理医学会総会  2005 

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  • 帯状疱疹後の神経痛に対する温泉療法の治療効果(その2)

    第70回日本温泉気候物理医学会総会  2005 

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  • 気管支喘息のn-3系不飽和脂肪酸強化食による食事療法

    第55回日本アレルギー学会秋季学術大会  2005 

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  • Mefloquineが著効した熱帯熱マラリアの1例

    第92回日本内科学会中国地方会  2005 

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  • 胃癌切除後に発症したANCA関連血管炎の1例

    第40回日本呼吸器学会中国四国地方会  2005 

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  • 再発性肺腺癌に対してラジオ波熱凝固療法が有効であった一例

    第40回日本呼吸器学会中国四国地方会  2005 

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  • 加齢における末梢循環血流量の経時的変化

    第47回日本老年医学会学術集会  2005 

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  • 気管支喘息患者における肺CT lung densitometryに対する加齢の影響―4年間の経過観察―

    第47回日本老年医学会学術集会  2005 

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  • 気管支喘息患者における肺CT lung densityの経年的変化―喫煙歴の有無による比較検討―

    第55回日本アレルギー学会秋季学術大会  2005 

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  • 巨大嚢胞を合併したインスリノーマの1例

    第17回日本老年医学会中国地方会  2005 

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  • 自己免疫性肝炎の経過中に遠位型腎尿細管性アシドーシス(1型)及び低カリウム性横紋筋融解症を合併した1例

    第93回日本内科学会中国地方会 2005.10.15(宇部)  2005 

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  • アクチノマイセス(放線菌)大腸炎の1例

    第93回日本内科学会中国地方会  2005 

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  • 各論4.呼吸器

    第25回温泉療法医研修会  2004 

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  • 高齢で肝炎の憎悪を認め、lamivudine投与が有効であったB型慢性肝炎の1例

    第90回日本内科学会中国地方会  2004 

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  • 呼吸器疾患の温泉療法ー22年間の入院症例2295例を対象にー

    第69回日本温泉気候物理医学会総会  2004 

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  • 肺気腫患者に対する5年間の温泉療法の臨床効果ー高分解能CT上のlow attenuation area、拡散能および残気量を中心にー

    第69回日本温泉気候物理医学会総会  2004 

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  • 気管支喘息における気道過敏性とロイコトリエン産生能との関連について

    第44回日本呼吸器学会総会  2004 

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  • COPD患者におけるHRCT上の%LAAと肺機能の経時的変化に関する検討

    第44回日本呼吸器学会総会  2004 

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  • 温泉治療対象者における閉塞性動脈硬化症の非侵襲的診断

    第69回日本温泉気候物理医学会総会  2004 

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  • 「温熱の多方面効果を科学する」2.呼吸器系の効果

    第69回日本温泉気候物理医学会総会  2004 

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  • 気管支喘息の気道過敏性に影響を及ぼす諸因子の検討

    第16回日本アレルギー学会春季臨床大会  2004 

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  • 気管支喘息における気道過敏性及びロイコトリエン産生に及ぼす諸因子の臨床的検討

    第101回日本内科学会総会  2004 

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  • 三朝におけるトロン濃度

    第47回日本放射線影響学会大会  2004 

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  • 三朝ラドン温泉地区住民の血液中のp53量とSOD活性の特性に関する検討

    第47回日本放射線影響学会大会  2004 

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  • 吸入ラドンの体内動態に関する基礎的検討 ―マウス体内からのラドン娘核種の検出―

    第47回日本放射線影響学会大会  2004 

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  • KL-6以上高値で推移した膠原病肺の1例

    第39回日本呼吸器学会中国四国地方会  2004 

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  • 高齢者喘息における気道過敏性およびロイコトリエン産性能

    第46回日本老年医学会学術集会・総会  2004 

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  • 高齢者の閉塞性動脈硬化症の非侵襲的早期診断

    第46回日本老年医学会学術集会・総会  2004 

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  • 高齢者気管支喘息における喫煙による気道過敏性の亢進と温泉療法の臨床効果

    第16回日本老年医学会中国地方会  2004 

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  • ケトプロフェン湿布剤により全身性麻疹様紅斑を来した1例

    第91回日本内科学会中国地方会  2004 

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  • 気管支喘息に対する年間薬剤費の重症度別検討

    第91回日本内科学会中国地方会  2004 

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  • 長期喫煙気管支喘息症例に対する温泉療法の臨床効果―気道過敏性,ロイコトリエン産生能による評価

    第54回日本アレルギー学会総会  2004 

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  • Characteristics of asthma in the elderly evaluated by high-resolution computed tomography and pulmonary function.

    13th ERS Annual Congress  2003 

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  • ラドン温泉適応症の機構に関する検討-ラドン効果とその他の効果との比較(2)- (平成15年10月6-8日、)

    第46回日本放射線影響学会  2003 

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  • 肺気腫に対するN-3系不飽和脂肪酸強化食の臨床効果

    第100回日本内科学会総会  2003 

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  • α-リノレン酸強化食の肺気腫に対する臨床効果

    第43回日本呼吸器学会総会  2003 

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  • 喫煙歴を有する気管支喘息患者の臨床的特徴

    第43回日本呼吸器学会総会  2003 

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  • 高齢者喘息における高分解能CT上の肺low attenuation area(LAA)に及ぼす長期間喫煙の影響 (平成15年6月18-20日、)

    第45回日本老年医学会学術集会  2003 

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  • 温泉療法が腰痛症患者のQOLに及ぼす効果 (平成15年6月17-19日、)

    第40回日本リハビリテーション医学会学術集会  2003 

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  • Fluvoxamineによりセロトニン症候群をきたしたParkinson病の1例

    第88回日本内科学会中国地方会  2003 

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  • 長期化学療法後にgefitinib(イレッサ)が奏功した術後再発肺腺癌の2例

    第88回日本内科学会中国地方会  2003 

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  • 当院における高齢者特発性間質性肺炎症例の臨床的検討

    第38回日本呼吸器学会中国四国地方会  2003 

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  • レーザードプラー血流計による高齢者の末梢循環の数量的解析

    第45回日本老年医学会学術集会  2003 

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  • Influence of long-term cigarette smoking on leukotriene production and bronchial hyperresponsiveness in asthmatics.

    99Th ATS/ALA International Conference  2003 

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  • 気管支喘息の病態に対する喫煙の影響 IgE反応系,気道過敏性,ロイコトリエン産生能を中心に

    第15回日本アレルギー学会春季臨床大会  2003 

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  • 早期診断早期治療にて軽快したMPO-ANCA関連血管炎の一例

    第15回日本アレルギー学会春季臨床大会  2003 

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  • 気管支喘息のIgE反応系,肺機能及び胸部HRCT所見に及ぼす長期喫煙の影響

    第100回日本内科学会総会  2003 

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  • Influence of aging and cigarette smoking on elderly patients with asthma.

    7th Asia/Oceania Regional Congress of Gerontology  2003 

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  • 感染を契機に急激に進行した高齢者特発性間質性肺炎の1例

    第15回日本老年医学会中国地方会  2003 

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  • 肝硬変及び肝細胞癌加療中に著しい血小板減少症を併発した1例

    第89回日本内科学会中国地方会  2003 

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  • 気管支喘息患者に対する温泉療法の薬剤費削減効果に対する検討

    第53回日本アレルギー学会総会  2003 

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  • Non-invasive study for peripheral circulation aged patients with arteriosclerosis and evaluation on therapy.

    7th Asia/Oceania Regional Congress of Gerontology  2003 

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  • 気管支喘息におけるn-3系脂肪酸補充療法の効果

    第2回呼吸ケアセミナー  2003 

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  • 気管支喘息における気道過敏性およびロイコトリエン産生能に及ぼす加齢および喫煙の影響

    第53回日本アレルギー学会総会  2003 

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  • ラドン温泉効果とマイナスイオン効果との関係に関する検討-ラドン療法用鉱石由来放射線とマイナスイオンの相関性-

    第46回日本放射線影響学会  2003 

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  • 胃食道逆流症治療による改善が期待されるのはどのような気管支喘息症例か?

    第42回日本呼吸器学会総会  2002 

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  • 白血球ロイコトリエン産生能における気管支喘息と肺気腫との比較検討

    第42回日本呼吸器学会総会  2002 

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  • 気管支喘息における肺のHRCT上のlow attenuation area および肺機能に及ぼす加齢の影響

    第99回日本内科学会講演会  2002 

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  • 高齢者喘息の病態的特徴-肺low attenuation area(LAA)<-950HU、肺機能、IgE反応系を中心に-

    第14回日本アレルギー学会春季臨床大会  2002 

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  • 呼吸器疾患症例における温泉療法の効果-アンケートを利用してー

    第67回日本温泉気候物理医学会総会  2002 

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  • 呼吸器疾患の温泉療法-地域医療と遠隔医療の比較-

    第67回日本温泉気候物理医学会総会 (平成14年5月16日-17日、  2002 

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  • 肺気腫の温泉療法-HRCT上の%LAAと温泉療法

    第67回日本温泉気候物理医学会総会  2002 

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  • 気管支喘息の温泉療法―High-resolution computed tomography(HRCT)上の%Low attenuation area と温泉療法-

    第67回日本温泉気候物理医学会総会 (平成14年5月16日-17日、  2002 

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  • 気管支喘息患者の免疫機能に対する熱気浴の効果

    第67回日本温泉気候物理医学会総会 (平成14年5月16日-17日、  2002 

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  • 胸部HRCT上のlow attenuation area(LAA)<-950HU及び肺機能で評価した気管支喘息患者の加齢変化

    第42回日本呼吸器学会総会  2002 

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  • 気管支喘息症例におけるステロイドによる病的椎体骨折閾値の検討

    第41回日本呼吸器学会総会  2001 

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  • 水中運動による肺気腫症例に対する呼吸器リハビリテーションの効果の基礎的検討

    第41回日本呼吸器学会総会  2001 

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  • α—リノレン酸強化食の気管支喘息に対する効果に影響する諸因子の検討

    第98回日本内科学会講演会  2001 

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  • 気管支喘息患者における肺機能と胸部高分解能CT(HRCT)上のLow attenuation area (LAA)に対する喫煙の影響

    第98回日本内科学会講演会  2001 

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  • 気管支喘息に対するN—3系不飽和脂肪酸強化食の効果に影響する諸因子の検討

    第41回日本呼吸器学会総会  2001 

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  • 高齢気管支喘息における気道過敏性と温泉療法の効果

    第66日本温泉気候物理医学会総会  2001 

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  • 高齢者の入浴, 温泉の問題点 3. 呼吸器疾患

    第66日本温泉気候物理医学会総会  2001 

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  • 気管支喘息におけるhigh-resolution computed tomography (HRCT)上のLow attenuation area (LAA) および換気機能に 及ぼす温泉療法の効果

    第66日本温泉気候物理医学会総会  2001 

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  • 温泉療法が著効した線維筋痛症の一例

    第84回日本内科学会中国地方会  2001 

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  • 気管支喘息の胸部高分解能CT(HRCT)によるLow attenuation area (LAA) の経時的変化

    第13回日本アレルギー学会春期臨床大会  2001 

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  • 寒冷負荷の末梢循環に及ぼす影響 その2

    第66日本温泉気候物理医学会総会  2001 

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  • 呼吸器疾患に対する温泉療法 —再入院症例を中心に—

    第66日本温泉気候物理医学会総会  2001 

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  • Bromocriptineにより白血球減少症及び血小板減少症をきたした Parkinson病の1例.

    第84回日本日本内科学会中国地方会  2001 

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  • ラベプラゾールテストを用いた気管支喘息増悪因子としての胃食道逆流の検討

    第13回日本アレルギー学会春期臨床大会  2001 

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  • 気管支喘息に対するN—3系不飽和脂肪酸強化食の長期摂取による臨床効果

    第13回日本アレルギー学会春期臨床大会  2001 

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  • 高齢気管支喘息症例のleukotriene産生能に関する臨床的検討

    第13回日本アレルギー学会春期臨床大会  2001 

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  • 水中における肺機能の比較—陸上との比較—

    第36回日本呼吸器学会中国四国地方会  2001 

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  • レーザードプラー血流計により測定された胃粘膜血流の 高齢者における特徴

    第43回日本老年医学会学術集会  2001 

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  • 高齢喘息患者の肺機能と胸部高分解能CT(HRCT)上のLow attenuation area (LAA) に及ぼす喫煙の影響

    第43回日本老年医学会学術集会  2001 

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  • 腰痛症患者における腰椎MRI画像所見の検討.

    第84回日本日本内科学会中国地方会  2001 

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  • Cortical bone parameters for the characterization of asthatic patients with glucocorticoid-induced vertebral fractures.

    Twenty-Third Annual Meeting of the American Society for Bone and Mineral Research  2001 

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  • 胃食道逆流症治療により改善が期待されるのはどのような気管支喘息症例か?

    第43回日本消化器病学会大会  2001 

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  • 気管支喘息の胸部高分解能CT(HRCT)によるLow attenuation area (LAA) —重症度との関連—

    第51回日本アレルギー学会総会  2001 

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  • 胸部解離性大動脈瘤と狭心症を伴った患者 (マルチスライスCT所見を中心に

    第85回日本日本内科学会中国地方会  2001 

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  • 高齢者における閉塞性動脈硬化症の非侵襲的早期診断。 マルチスライスCTを用いた末梢血管の観察

    第13回日本老年医学会中国地方会  2001 

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  • 高齢者喘息の気腫化傾向

    第13回日本老年医学会中国地方会  2001 

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  • 胃食道逆流症治療により改善が期待される気管支喘息症例の臨床像

    第51回日本アレルギー学会総会  2001 

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  • 糖尿病患者における局所寒冷負荷の全身末梢循環に及ぼす影響

    第85回日本日本内科学会中国地方会  2001 

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  • 気管支喘息肺気腫の白血球ロイコトリエン産生能における 比較検討

    第51回日本アレルギー学会総会  2001 

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Awards

  • 第29回 温泉関係功労者被表彰者

    2010.7   環境省  

    光延文裕

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  • 平成15年度岡山医学賞(砂田賞)

    2004.6  

    光延文裕

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  • Paper of the year in J. Jpn. Assoc. Phys. Med. Balneol. Climatol.

    1999.4  

    Fumihiro Mitsunobu

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    Country:Japan

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Class subject in charge

  • Research Presentation in Pathophysiology (2021academic year) special  - その他

  • advanced health sciences (2021academic year) Late  - その他

  • Gerontology (2021academic year) special  - その他

  • Research Projects and Practicals: Longevity and Social Medicine I (2021academic year) special  - その他

  • Lecture and Research Projects: Longevity and Social Medicine I (2021academic year) special  - その他

  • Research Projects and Practicals: Longevity and Social Medicine II (2021academic year) special  - その他

  • Lecture and Research Projects: Longevity and Social Medicine II (2021academic year) special  - その他

  • Lecture : Elderly healthcare (2021academic year) special  - その他

  • Elective Clinical Practice (Gerontology) (2021academic year) special  - その他

  • Topics in Applied Therapeutic Radiology (2020academic year) Summer concentration  - その他

  • Research Presentation in Pathophysiology (2020academic year) Year-round  - その他

  • Pathophysiology (2020academic year) Year-round  - その他

  • advanced health sciences (2020academic year) Late  - その他

  • Gerontology (2020academic year) special  - その他

  • Research Projects and Practicals: Longevity and Social Medicine I (2020academic year) special  - その他

  • Lecture and Research Projects: Longevity and Social Medicine I (2020academic year) special  - その他

  • Research Projects and Practicals: Longevity and Social Medicine II (2020academic year) special  - その他

  • Lecture and Research Projects: Longevity and Social Medicine II (2020academic year) special  - その他

  • Lecture : Elderly healthcare (2020academic year) special  - その他

  • Elective Clinical Practice (Gerontology) (2020academic year) special  - その他

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