2024/09/18 更新

写真a

スガヤ アキコ
菅谷 明子
SUGAYA AKIKO
所属
医歯薬学域 講師
職名
講師
外部リンク

学位

  • 医学博士 ( 2014年6月   岡山大学 )

研究キーワード

  • 耳科学

  • 人類遺伝学

  • 小児難聴

  • 言語発達

  • 人工内耳

研究分野

  • ライフサイエンス / 耳鼻咽喉科学

学歴

  • 岡山大学    

    - 2014年

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  • 岡山大学   Medical School   Faculty of Medicine

    - 2003年

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経歴

  • 岡山大学学術研究院医歯薬学域   耳鼻咽喉・頭頸部外科学   講師

    2024年8月 - 現在

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  • 岡山大学   耳鼻咽喉・頭頸部外科   助教

    2017年4月 - 2024年7月

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  • 岡山大学   耳鼻咽喉科   医員

    2010年4月 - 2017年3月

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  • 岡山済生会総合病院   耳鼻咽喉科

    2007年6月 - 2010年3月

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  • 広島市立広島市民病院   耳鼻咽喉科

    2005年4月 - 2007年5月

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所属学協会

  • 日本遺伝カウンセリング学会

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  • 日本耳科学会

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  • 日本耳鼻咽喉科頭頸部外科学会

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委員歴

  • 小児難聴相談医ワーキンググループ  

    2023年11月   

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  • 日本耳鼻咽喉科頭頸部外科学会   乳幼児医療委員会  

    2020年6月 - 現在   

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    団体区分:学協会

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論文

  • Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss. 査読

    Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando

    Acta medica Okayama   78 ( 4 )   349 - 355   2024年8月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment.

    DOI: 10.18926/AMO/67554

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  • 『今から始めるこどもから大人への移行支援』難聴児のスキル獲得のための多職種連携支援について考える 招待 査読

    菅谷 明子

    小児耳鼻咽喉科   45 ( 1 )   10 - 14   2024年6月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:日本小児耳鼻咽喉科学会  

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  • Cochlear Implantation in the Poorer-Hearing Ear Is a Reasonable Choice. 査読

    Ryotaro Omichi, Shin Kariya, Yukihide Maeda, Kunihiro Fukushima, Yuko Kataoka, Akiko Sugaya, Kazunori Nishizaki, Mizuo Ando

    Acta medica Okayama   77 ( 6 )   589 - 593   2023年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of 'better-hearing ear' was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient's age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and -0.33, 95% confidence intervals [11.75-37.45] and [-0.58 to -0.09], respectively), but the CI surgery side did not (-6.76, [-14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing.

    DOI: 10.18926/AMO/66150

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  • 突発性難聴治療に対する新型コロナウイルス感染症の影響

    大道 亮太郎, 佐藤 明日香, 菅谷 明子, 前田 幸英, 片岡 祐子, 安藤 瑞生

    日本耳科学会総会・学術講演会抄録集   33回   260 - 260   2023年11月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 切除不能中耳粘膜悪性黒色腫に対して陽子線治療及びニボルマブ投与を実施した一例

    佐藤 明日香, 安藤 瑞生, 假谷 伸, 片岡 祐子, 前田 幸英, 菅谷 明子, 大道 亮太郎

    日本耳科学会総会・学術講演会抄録集   33回   314 - 314   2023年11月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 一般地域住民における難聴の実地調査 難聴に関する公開講座参加者を対象に

    浜本 真一, 假谷 伸, 菅谷 明子, 片岡 祐子, 前田 幸英, 大道 亮太郎, 安藤 瑞生, 原 浩貴

    日本耳科学会総会・学術講演会抄録集   33回   283 - 283   2023年11月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • Revision cochlear implant surgery in adults and children is a safe and effective technique: a retrospective single faculty study in Okayama University Hospital, Japan. 査読 国際誌

    Akiko Sugaya, Shin Kariya, Kunihiro Fukushima, Ryotaro Omichi, Mizuo Ando

    Acta oto-laryngologica   1 - 5   2023年10月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cochlear implant (CI) surgery is a safe surgical technique, although some patients require revision CI surgery. AIMS/OBJECTIVES: This study investigated the cause and underlying reason of revision CI surgery as well as hearing outcomes in a single institution. PATIENTS AND METHODS: This retrospective study evaluated patients who underwent CI surgery between April 2006 to March 2022 (n = 351). Sex, aetiology of hearing loss (HL), age and period from initial CI surgery to reimplantation, cause of revision, and related factors were examined. RESULTS: Twelve patients (8 males, 4 females) received CI reimplantation. The revision surgery rate was 2.59% (3.15% children, 1.69% adults); the period from initial surgery to reoperation was 8.60 ± 6.56 years for 9 children with congenital HL and 15.27 ± 5.72 years for 3 adults with progressive HL. Device failure was the most common cause (n = 8), followed by infections (n = 2), advanced facial irritation symptoms (n = 1), and electrode slip-out (n = 1). Mean preoperative and postoperative CI thresholds were 44.0 ± 9.46 dBnHL and 39.19 ± 8.89 dBnHL (p < .068), respectively. CONCLUSION AND SIGNIFICANCE: Caregiver education, surgical technique advances, flap design, and extensive antibiotic use may decrease the revision surgery rate. The lack of post-revision deterioration of the hearing threshold contributed to well-being in patients with CI.

    DOI: 10.1080/00016489.2023.2270701

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  • Evaluation of the ear ossicles with photon-counting detector CT. 査読

    Yuka Takahashi, Fumiyo Higaki, Akiko Sugaya, Yudai Asano, Katsuhide Kojima, Yusuke Morimitsu, Noriaki Akagi, Toshihide Itoh, Yusuke Matsui, Takao Hiraki

    Japanese journal of radiology   2023年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Recently, computed tomography with photon-counting detector (PCD-CT) has been developed to enable high-resolution imaging at a lower radiation dose. PCD-CT employs a photon-counting detector that can measure the number of incident X-ray photons and their energy. The newly released PCD-CT (NAEOTOM Alpha, Siemens Healthineers, Forchheim, Germany) has been in clinical use at our institution since December 2022. The PCD-CT offers several advantages over current state-of-the-art energy-integrating detector CT (EID-CT). The PCD-CT does not require septa to create a detector channel, while EID-CT does. Therefore, downsizing the anode to achieve higher resolution does not affect the dose efficiency of the PCD-CT. CT is an indispensable modality for evaluating ear ossicles. The ear ossicles and joints are clearly depicted by PCD-CT. In particular, the anterior and posterior legs of the stapes, which are sometimes unclear on conventional CT scans, can be clearly visualized. We present cases of congenital anomalies of the ossicular chain, ossicular chain dislocation, tympanosclerosis, and cholesteatoma in which PCD-CT was useful. This short article reports the usefulness of PCD-CT in the 3D visualization of the ear ossicles.

    DOI: 10.1007/s11604-023-01485-0

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  • Cogan症候群に対して人工内耳植込術を施行した一例

    佐藤 明日香, 安藤 瑞生, 假谷 伸, 片岡 祐子, 前田 幸英, 菅谷 明子, 大道 亮太郎

    日本耳科学会総会・学術講演会抄録集   32回   271 - 271   2022年10月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 人工内耳装用児の術後コミュニケーション状態における術前CTによる前庭水管拡大症の影響の検討

    菅谷 明子, 假谷 伸, 福島 邦博, 片岡 祐子, 前田 幸英, 大道 亮太郎, 安藤 瑞生

    日本耳科学会総会・学術講演会抄録集   32回   342 - 342   2022年10月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 小児難聴と人工聴覚器

    假谷 伸, 菅谷 明子, 片岡 祐子

    耳鼻咽喉科   2 ( 2 )   263 - 269   2022年8月

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    記述言語:日本語   出版者・発行元:(有)科学評論社  

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  • Correction to: Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. 査読 国際誌

    Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoshimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

    Human genetics   141 ( 3-4 )   993 - 995   2022年4月

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  • Etiology of hearing loss affects auditory skill development and vocabulary development in pediatric cochlear implantation cases. 査読 国際誌

    Shin-Ya Nishio, Hideaki Moteki, Maiko Miyagawa, Tatsuya Yamasoba, Akinori Kashio, Satoshi Iwasaki, Masahiro Takahashi, Yasushi Naito, Keizo Fujiwara, Akiko Sugaya, Haruo Takahashi, Kyoko Kitaoka, Shin-Ichi Usami

    Acta oto-laryngologica   142 ( 3-4 )   308 - 315   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Cochlear implantation (CI) is an effective treatment for severe-to-profound hearing loss patients and is currently used as the standard therapeutic option worldwide. However, the outcomes of CI vary among patients. AIMS/OBJECTIVES: This study aimed to clarify the clinical features for each etiological group as well as the effects of etiology on CI outcomes. MATERIALS AND METHODS: We collected clinical information for 308 pediatric cochlear implant cases, including the etiology, hearing thresholds, age at CI, early auditory skill development, total development, monosyllable perception, speech intelligibility and vocabulary development in school age, and compared them for each etiology group. RESULTS: Among the 308 CI children registered for this survey, the most common etiology of hearing loss was genetic causes. The genetic etiology group showed the most favorable development after CI followed by the unknown etiology group, syndromic hearing loss group, congenital CMV infection group, inner ear malformation group, and cochlear nerve deficiency group. CONCLUSIONS AND SIGNIFICANCE: Our results clearly indicated that the etiology of HL affects not only early auditory skill development, but also vocabulary development in school age. The results of the present study will aid in more appropriate CI outcome assessment and in more appropriate intervention or habilitation programs.

    DOI: 10.1080/00016489.2022.2065027

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  • Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. 査読 国際誌

    Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoishimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

    Human genetics   141 ( 3-4 )   865 - 875   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype-phenotype correlation in patients with OTOF mutations is not yet fully understood. In this study, we aimed to reveal detailed clinical characteristics of OTOF-related hearing loss patients and the genotype-phenotype correlation. Detailed clinical information was available for 64 patients in our database who were diagnosed with OTOF-related hearing loss. As reported previously, most of the patients (90.6%) showed a "typical" phenotype; prelingual and severe-to-profound hearing loss. Forty-seven patients (73.4%) underwent cochlear implantation surgery and showed successful outcomes; approximately 85-90% of the patients showed a hearing level of 20-39 dB with cochlear implant and a Categories of Auditory Performance (CAP) scale level 6 or better. Although truncating mutations and p.Arg1939Gln were clearly related to severe phenotype, almost half of the patients with one or more non-truncating mutations showed mild-to-moderate hearing loss. Notably, patients with p.His513Arg, p.Ile1573Thr and p.Glu1910Lys showed "true" auditory neuropathy-like clinical characteristics. In this study, we have clarified genotype-phenotype correlation and efficacy of cochlear implantation for OTOF-related hearing loss patients in the biggest cohort studied to date. We believe that the clinical characteristics and genotype-phenotype correlation found in this study will support preoperative counseling and appropriate intervention for OTOF-related hearing loss patients.

    DOI: 10.1007/s00439-021-02351-7

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  • 思春期から青年期の難聴者が持つ代償・補償スキルと知識に関する一考察

    中川 敦子, 片岡 祐子, 田中 里実, 細川 夏実, 菅谷 明子, 假谷 伸

    Audiology Japan   64 ( 5 )   389 - 389   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本聴覚医学会  

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  • Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss. 査読

    Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

    Acta medica Okayama   75 ( 4 )   511 - 516   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

    DOI: 10.18926/AMO/62404

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  • Immediate changes in transcription factors and synaptic transmission in the cochlea following acoustic trauma: A gene transcriptome study. 査読 国際誌

    Yukihide Maeda, Shin Kariya, Kensuke Uraguchi, Junko Takahara, Shohei Fujimoto, Akiko Sugaya, Kazunori Nishizaki

    Neuroscience research   165   6 - 13   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pathologic mechanisms in cochleae immediately following the onset of noise-induced hearing loss (NIHL) remain unclear. In this study, mice were exposed to 120 dB of octave band noise for 2 h to induce NIHL. Three hours after noise exposure, expression levels of the whole mouse genome in cochleae were analyzed by RNA-seq and DNA microarray. Differentially expressed genes (DEGs) exhibiting >2-fold upregulation or downregulation in noise-exposed cochleae compared to controls without noise exposure were identified. RNA-seq and microarray analyses identified 273 DEGs regulated at 3 h post-noise (51 upregulated and 222 downregulated). Bioinformatic analysis revealed that these DEGs were associated with the functional gene pathway "neuroactive ligand-receptor interaction" and included 28 genes encoding receptors for neurotransmitters such as gamma-aminobutyric acid and glutamate. Other DEGs included 25 genes encoding transcription factors. Downregulation of 4 neurotransmitter receptors (Gabra3, Gabra5, Gabrb1, Grm1) and upregulations of 5 transcription factors (Atf3, Dbp, Helt, Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting cells and hair cells in the organ of Corti at 12-h post-noise. The present data serve as a basis for further studies aimed at developing medical treatments for acute sensorineural hearing loss.

    DOI: 10.1016/j.neures.2020.05.001

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  • Fertility Preservation Therapy Provided for Childhood, Adolescent, and Young Adult Cancer Patients —Current Status and Efforts to Improvement—,小児,思春期・若年がん患者に対する妊孕性温存療法―現状と改善の取り組み―

    Akisada, N., Makino, T., Sugaya, A., Kataoka, Y., Ando, M., Monden, N., Nakatsuka, M.

    Practica Oto-Rhino-Laryngologica   114 ( 12 )   2021年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.5631/jibirin.114.957

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  • Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. 査読 国際誌

    Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

    International journal of pediatric otorhinolaryngology   138   110298 - 110298   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

    DOI: 10.1016/j.ijporl.2020.110298

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  • Progression of hearing loss and choice of hearing aids by patients in their 60s, 70s, and 80s and older: experience in the Japanese super-aged era. 査読

    139   1077 - 1082   2019年9月

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  • Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. 査読

    126   109619 - 109619   2019年8月

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    担当区分:筆頭著者, 責任著者  

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  • Relationship between pure-tone audiogram findings and speech perception among older Japanese persons. 査読 国際誌

    Maeda Y, Takao S, Sugaya A, Kataoka Y, Kariya S, Tanaka S, Nagayasu R, Nakagawa A, Nishizaki K

    Acta Otolaryngol.   138 ( 2 )   140 - 144   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/00016489.2017.1378435

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  • Targeted PCR Array Analysis of Genes in Innate Immunity and Glucocorticoid Signaling Pathways in Mice Cochleae Following Acoustic Trauma. 査読 国際誌

    Maeda Y, Kariya S, Omichi R, Noda Y, Sugaya A, Fujimoto S, Nishizaki K

    Otol Neurotol.   39 ( 7 )   e593 - e600   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MAO.0000000000001874

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  • WFS1 mutation screening in a large series of Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis. 査読 国際誌

    Masafumi Kobayashi, Maiko Miyagawa, Shin-Ya Nishio, Hideaki Moteki, Taro Fujikawa, Kenji Ohyama, Hirofumi Sakaguchi, Ikuyo Miyanohara, Akiko Sugaya, Yasushi Naito, Shin-Ya Morita, Yukihiko Kanda, Masahiro Takahashi, Kotaro Ishikawa, Yuki Nagano, Tetsuya Tono, Chie Oshikawa, Chiharu Kihara, Haruo Takahashi, Yoshihiro Noguchi, Shin-Ichi Usami

    PloS one   13 ( 3 )   e0193359   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A heterozygous mutation in the Wolfram syndrome type 1 gene (WFS1) causes autosomal dominant nonsyndromic hereditary hearing loss, DFNA6/14/38, or Wolfram-like syndrome. To date, more than 40 different mutations have been reported to be responsible for DFNA6/14/38. In the present study, WFS1 variants were screened in a large series of Japanese hearing loss (HL) patients to clarify the prevalence and clinical characteristics of DFNA6/14/38 and Wolfram-like syndrome. Massively parallel DNA sequencing of 68 target genes was performed in 2,549 unrelated Japanese HL patients to identify genomic variations responsible for HL. The detailed clinical features in patients with WFS1 variants were collected from medical charts and analyzed. We successfully identified 13 WFS1 variants in 19 probands: eight of the 13 variants were previously reported mutations, including three mutations (p.A684V, p.K836N, and p.E864K) known to cause Wolfram-like syndrome, and five were novel mutations. Variants were detected in 15 probands (2.5%) in 602 families with presumably autosomal dominant or mitochondrial HL, and in four probands (0.7%) in 559 sporadic cases; however, no variants were detected in the other 1,388 probands with autosomal recessive or unknown family history. Among the 30 individuals possessing variants, marked variations were observed in the onset of HL as well as in the presence of progressive HL and tinnitus. Vestibular symptoms, which had been rarely reported, were present in 7 out of 30 (23%) of the affected individuals. The most prevalent audiometric configuration was low-frequency type; however, some individuals had high-frequency HL. Haplotype analysis in three mutations (p.A716T, p.K836T, and p.E864K) suggested that the mutations occurred at these mutation hot spots. The present study provided new insights into the audiovestibular phenotypes in patients with WFS1 mutations.

    DOI: 10.1371/journal.pone.0193359

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  • 中耳炎により外科的処置を要した小児人工内耳装用例の検討

    片岡 祐子, 假谷 伸, 菅谷 明子, 大道 亮太郎, 福島 邦博, 西崎 和則

    小児耳鼻咽喉科   38 ( 2 )   153 - 153   2017年5月

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    記述言語:日本語   出版者・発行元:日本小児耳鼻咽喉科学会  

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  • 次世代シークエンサー(NGS)を併用した難聴遺伝子検査が有用であった3症例

    菅谷 明子, 片岡 祐子, 前田 幸英, 假谷 伸, 大道 亮太郎, 峠 和美, 佐藤 吏江, 西崎 和則

    日本遺伝カウンセリング学会誌   38 ( 2 )   120 - 120   2017年5月

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    記述言語:日本語   出版者・発行元:(一社)日本遺伝カウンセリング学会  

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  • 新生児聴覚スクリーニング実施における費用対効果の検討

    片岡 祐子, 菅谷 明子, 西崎 和則

    日本耳鼻咽喉科学会会報   120 ( 4 )   588 - 588   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • Cochlear Transcriptome Following Acoustic Trauma and Dexamethasone Administration Identified by a Combination of RNA-seq and DNA Microarray. 査読 国際誌

    Maeda Y, Omichi R, Sugaya A, Kariya S, Nishizaki K

    Otol Neurotol.   38 ( 7 )   1032 - 1042   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MAO.0000000000001373

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  • Genetic counseling of a hearing-impaired patient with multiple genetic mutations 査読

    Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Kunihiro Fukushima, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   120 ( 2 )   131 - 136   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    Since April 2012, genetic testing for congenital hearing loss is covered by the public health insurance in Japan. Recent(since August 2015)developments in next-generation sequencing technology have enabled the detection of 154 mutations in 19 genes. Genetic testing provides valuable information on hearing phenotype, prognosis, and prediction of associated symptoms. We report a hearing-impaired patient in whom multiple genetic mutations were detected. This patient carries two missense mutations in GJB2(p.G45E, p.Y136X), as well as a mitochondrial mutation(7445A&gt
    G). Since the number of genes detectable by genetic testing has increased, the diagnosis of hearing loss can be made with greater accuracy. However, it is often difficult to clinically understand and interpret the genotype information, especially when multiple gene variants are detected in one patient or family. Genetic counseling plays an important part in the intervention for or follow-up of such patients. Genotypic and phenotypic information of other family members is necessary, so that both the patient and the family can understand and accept the results of genetic testing.

    DOI: 10.3950/jibiinkoka.120.131

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  • Reversal of the inner magnet of a cochlear implant after magnet resonance imaging 査読

    Yuko Kataoka, Tomoyuki Naito, Shin Kariya, Akiko Sugaya, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   120 ( 5 )   727 - 732   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    In general, patients with recent versions of cochlear implants(CIs)can safely undergo Magnetic Resonance Imaging (MRI) within 1.5 T scanners, without the need of inner magnet removal surgery. However, even if they wear tight head bandages on their inner coil, complications can occur in CI users during MRI, such as pain, skin reaction, demagnetization of the internal magnet, and dislocation of the magnet out of its silicon flange. We encountered two cases of reversal of the inner magnet of a CI during MRI examination. In both cases, the inner magnets were reversed by 180 degrees, although they remained in the silicon flange. We ordered a polar-changed extra magnet for replacing the reversed inner magnet in one case, and performed a re-implant surgery of the inner magnet in the other. In recent years, the number of hearing-impaired patients with CIs has been increasing along with expansion of the medical indications for CI in the rapidly aging population of the developed countries. On the other hand, MRI is an indispensable clinical diagnostic tool in modern medical practice. Physicians and paramedics must be aware of possible complications that can occur during MRI in patients with CIs. Prompt assessment and appropriate treatment are important in patients with CIs developing complications during MRI examination.

    DOI: 10.3950/jibiinkoka.120.727

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  • Pediatric central auditory processing disorder showing elevated threshold on pure tone audiogram 査読

    Yukihide Maeda, Atsuko Nakagawa, Rie Nagayasu, Akiko Sugaya, Ryotaro Omichi, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

    AURIS NASUS LARYNX   43 ( 5 )   570 - 574   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Central auditory processing disorder (CAPD) is a condition in which dysfunction in the central auditory system causes difficulty in listening to conversations, particularly under noisy conditions, despite normal peripheral auditory function. Central auditory testing is generally performed in patients with normal hearing on the pure tone audiogram (PTA). This report shows that diagnosis of CAPD is possible even in the presence of an elevated threshold on the PTA, provided that the normal function of the peripheral auditory pathway was verified by distortion product otoacoustic emission (DPOAE), auditory brainstem response (ABR), and auditory steady state response (ASSR). Three pediatric cases (9- and 10-year-old girls and an 8-year-old boy) of CAPD with elevated thresholds on PTAs are presented. The chief complaint was difficulty in listening to conversations. PTA showed elevated thresholds, but the responses and thresholds for DPOAE, ABR, and ASSR were normal, showing that peripheral auditory function was normal. Significant findings of central auditory testing such as dichotic speech tests, time compression of speech signals, and binaural interaction tests confirmed the diagnosis of CAPD. These threshold shifts in PTA may provide a new concept of a clinical symptom due to central auditory dysfunction in CAPD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.anl.2016.02.005

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  • Subjective hearing-related quality-of-life is a major factor in the decision to continue using hearing aids among older persons 査読

    Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

    ACTA OTO-LARYNGOLOGICA   136 ( 9 )   919 - 922   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Conclusion: Audiological parameters alone do not determine the choice to use hearing aids (HA). Subjective hearing-related QoL is a major factor that determines whether or not an older person will continue to wear HA.Objective: This study aimed to identify which audiological parameters and quality-of-life (QoL) measures determine whether or not older persons will continue wearing HA.Methods: Charts of 157 patients aged 65 years who attended the HA service unit at the Otolaryngology Department were retrospectively reviewed. After HA fitting and a trial, the patients were divided into groups, depending upon whether or not they wanted to continue wearing the HA (users, 58.2%; non-users, 41.8%) and then audiological parameters were compared between them. At least 4 months after the HA fitting, the self-reported QoL questionnaire, Hearing Handicap Inventory for the Elderly (HHIE), was mailed to all 157 patients and HHIE scores were compared between HA users and non-users.Result: Speech discrimination score and dynamic range did not significantly differ between HA users and non-users. A difference in the average hearing threshold was marginally significant. The response rate to the HHIE was 65.2%. Total HHIE and emotional scores were higher (more impaired) among HA users than non-users.

    DOI: 10.1080/00016489.2016.1183817

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  • 急性感音難聴モデルマウスへのステロイド投与後の内耳遺伝子発現 RNA-seqとDNAマイクロアレイを用いた解析

    前田 幸英, 大道 亮太郎, 菅谷 明子, 片岡 祐子, 假谷 伸, 西崎 和則

    Otology Japan   26 ( 4 )   489 - 489   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 人工内耳装用児の英語学習における実態調査

    菅谷 明子, 福島 邦博, 谷 伸, 長安 吏江, 藤吉 昭江, 片岡 祐子, 前田 幸英, 西崎 和則

    Otology Japan   26 ( 4 )   405 - 405   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 乳幼児鼓膜インピーダンス測定における1000Hz tympanometryの有用性の検討

    片岡 祐子, 菅谷 明子, 假谷 伸, 大道 亮太郎, 前田 幸英, 福島 邦博, 西崎 和則

    Otology Japan   26 ( 4 )   449 - 449   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • MRI検査後に人工内耳インプラントのマグネットの反転を来たした2例

    内藤 智之, 片岡 祐子, 假谷 伸, 菅谷 明子, 大道 亮太郎, 前田 幸英, 西崎 和則

    Otology Japan   26 ( 4 )   570 - 570   2016年9月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • 頸部リンパ管腫に合併した滲出性中耳炎の1例

    大道 亮太郎, 菅谷 明子, 前田 幸英, 片岡 祐子, 假谷 伸, 西崎 和則

    耳鼻咽喉科臨床 補冊   ( 補冊146 )   99 - 99   2016年6月

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    記述言語:日本語   出版者・発行元:耳鼻咽喉科臨床学会  

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  • 岡山県における小児難聴例の診断時期の検討

    片岡 祐子, 鳥越 暁子, 菅谷 明子, 大道 亮太郎, 前田 幸英, 福島 邦博

    小児耳鼻咽喉科   37 ( 2 )   129 - 129   2016年5月

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    記述言語:日本語   出版者・発行元:日本小児耳鼻咽喉科学会  

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  • 人工内耳装用前の早期補聴が言語発達に与える効果の検証

    菅谷 明子, 福島 邦博, 笠井 紀夫, 藤吉 昭江, 長安 吏江, 片岡 祐子, 前田 幸英, 西崎 和則

    小児耳鼻咽喉科   37 ( 2 )   126 - 126   2016年5月

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    記述言語:日本語   出版者・発行元:日本小児耳鼻咽喉科学会  

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  • 純音聴力閾値上昇を呈した聴覚情報処理障害の小児例

    前田 幸英, 菅谷 明子, 片岡 祐子, 大道 亮太郎, 假谷 伸, 福島 邦博, 西崎 和則

    日本耳鼻咽喉科学会会報   119 ( 4 )   618 - 618   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • 初回手術後に長期間経過して対側人工内耳埋込術を施行された高度感音難聴児6例の検討

    菅谷 明子, 福島 邦博, 假谷 伸, 長安 吏江, 片岡 祐子, 前田 幸英, 大道 亮太郎, 西崎 和則

    日本耳鼻咽喉科学会会報   119 ( 4 )   619 - 619   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy 査読

    Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Rie Nagayasu, Atsuko Nakagawa, Toru Yamashita, Koji Abe, Kazunori Nishizaki

    ACTA OTO-LARYNGOLOGICA   136 ( 3 )   266 - 270   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Conclusion: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). Objective: This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms. Methods: The shape and threshold of pure-tone audiograms were evaluated for MSA-C (n = 47; mean (+/- SD) age, 61.6 +/- 8.9 years), CCA (n = 16; 62.8 +/- 9.5 years), and age-matched controls (n = 169; 62.5 +/- 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria. Results: When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208-5.139; p &lt; 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709-6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320-7.969) and 3.692 (95% CI = 1.052-12.957), respectively, significantly higher than in controls.

    DOI: 10.3109/00016489.2015.1104722

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  • Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants 査読

    Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Yuko Kataoka, Yukihide Maeda, Rie Nagayasu, Naomi Toida, Shyuhei Ohmori, Akie Fujiyoshi, Tomoko Taguchi, Ryotaro Omichi, Kazunori Nishizaki

    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY   79 ( 12 )   2142 - 2146   2015年12月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objectives: Early hearing detection and intervention (EHDI) is critical for achievement of age-appropriate speech perception and language development in hearing-impaired children. It has been 15 years since newborn hearing screening (NHS) was introduced in Japan, and its effectiveness for language development in hearing-impaired children has been extensively studied. Moreover, after over 20 years of cochlear implantation in Japan, many of the prelingual cochlear implant (CI) users have reached school age, and the effect of Clan language development have also been assessed. To identify prognostic factors for language development, audiological/language test scores and demographic factors were compared among prelingual severe-to-profound hearing-impaired children with CI divided into subgroups according to age at first hearing aid (HA) use and whether they received NHS.
    Methods: Prelingual severe-to-profound deafened children from the Research on Sensory and Communicative Disorders (RSCD) project who met the inclusion criteria were divided into groups according to the age (in months) of HA commencement (before 6 months: group A, after 7 months: group B), and the presence or absence of NHS (groups C and D). Language development and socio-economic data were obtained from audiological/language tests and a questionnaire completed by caregivers, respectively.
    Results: In total, 210 children from the RSCD project participated in this study. Group A (n = 49) showed significantly higher scores on comprehensive vocabulary and academic achievement (p &lt; 0.05) than group B (n = 161), with no difference in demographics except for significantly older age in group B. No differences in language scores were observed between group C (n = 71) and group D (n = 129), although participants of group D was significantly older and had used CIs longer (p &lt; 0.05).
    Conclusions: Early use of HAs until the CI operation may result in better language perception and academic achievement among Cl users with prelingual deafness. A long-term follow-up is required to assess the usefulness of NHS for language development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijporl.2015.09.036

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  • Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy 査読

    Yukihide Maeda, Yuko Kataoka, Akiko Sugaya, Shin Kariya, Katsuhiro Kobayashi, Kazunori Nishizaki

    AURIS NASUS LARYNX   42 ( 3 )   249 - 253   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Charcot-Marie-Tooth disease (CMT) is the most common form of hereditary sensorimotor neuropathy and sometimes involves disorders of the peripheral auditory system. We present a case of steroid-dependent auditory neuropathy associated with CMT, in which the patient experienced 3 episodes of acute exacerbation of hearing loss and successful rescue of hearing by prednisolone. An 8-year-old boy was referred to the otolaryngology department at the University Hospital. He had been diagnosed with CMT type 1 (demyelinating type) at the Child Neurology Department and was suffering from mild hearing loss due to auditory neuropathy. An audiological diagnosis of auditory neuropathy was confirmed by auditory brainstem response and distortion-product otoacoustic emissions. At 9 years and 0 months old, 9 years and 2 months old, and 10 years and 0 months old, he had experienced acute exacerbations of hearing loss, each of which was successfully rescued by intravenous or oral prednisolone within 2 weeks. Steroid-responsive cases of CMT have been reported, but this is the first case report of steroid-responsive sensorineural hearing loss in CMT. The present case may have implications for the mechanisms of action of glucocorticoids in the treatment of sensorineural hearing loss. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.anl.2014.11.002

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  • Novel ABHD12 Mutations in PHARC Patients: The Differential Diagnosis of Deaf-Blindness 査読

    Hidekane Yoshimura, Takao Hashimoto, Toshinori Murata, Kunihiro Fukushima, Akiko Sugaya, Shin-ya Nishio, Shin-ichi Usami

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   124 ( 1 )   77S - 83S   2015年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS INC  

    Objective: This study examines ABHD12 mutation analysis in 2 PHARC patients, originally thought to be Usher syndrome.
    Methods: The ABHD12 gene of 2 patients, who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems, were sequenced.
    Results: We identified that both cases carried the same novel splice site mutation in the ABHD12 gene. However, 1 had epilepsy and the other had peripheral neuropathy. Based on haplotype analysis, the mutation is likely not a hot spot, but rather could be attributable to a common ancestor.
    Conclusion: This study, shows that PHARC has phenotypic variability, even within a family, which is consistent with previous reports. Differential diagnosis of "deaf-blindness" diseases is crucial. Confirming the presence of associated symptoms is necessary for differentiating some deaf-blindness syndromes. In addition, mutation analysis is a useful tool for confirming the diagnosis.

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  • 岡山県内胃瘻造設術施行施設へのアンケートからみる嚥下機能評価における耳鼻咽喉科医の役割

    西崎 和則, 春名 威範, 牧野 琢丸, 三木 健太郎, 野田 洋平, 檜垣 貴哉, 菅谷 明子, 小野田 友男

    日本耳鼻咽喉科学会会報   118 ( 4 )   501 - 501   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本耳鼻咽喉科学会  

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  • Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan 査読

    Shuhei Ohmori, Akiko Sugaya, Naomi Toida, Etsuji Suzuki, Masato Izutsu, Tomoko Tsutsui, Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY   79 ( 2 )   196 - 201   2015年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: Permanent hearing impairment has a life-long impact on children and its early identification is important for language development. A newborn hearing screening (NHS) program has started in Okayama Prefecture, Japan, in 1999 to detect hearing impairment immediately after birth. We aim to examine the effect of this screening program on vocabulary development in pre-school children in a before and after comparative study design.
    Methods: A total of 107 5-year-old children who graduated from Okayama Kanariya Gakuen (an auditory center for hearing-impaired children) between 1998 and 2011 were enrolled in this study. The pre-NHS group (n = 40) was defined as those who graduated between 1998 and 2003, while the post-NHS group (n = 67) was defined as those who graduated between 2004 and 2011. The primary outcome was receptive vocabulary, which was assessed by the Picture Vocabulary Test [score &lt;18 (low) vs. score &gt;18 (high)]. The secondary outcome was productive vocabulary, or the number of productive words, which was assessed by an original checklist [&lt;1773 words (low) vs. &gt;1773 (high)]. We calculated odds ratios and 95% confidence intervals for vocabulary development and compared both groups.
    Results: The adjusted Picture Vocabulary Test score and number of productive words were significantly higher (p &lt; 0.01) in the post-NHS group than the pre-NHS group. Odds ratios were 2.63 (95% confidence interval: 1.17-5.89) for receptive vocabulary and 4.17 (95% confidence interval: 1.69-10.29) for productive vocabulary.
    Conclusions: The introduction of NHS in Okayama Prefecture significantly improved both receptive and productive vocabulary development in hearing-impaired children. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.ijporl.2014.12.006

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  • Outcomes of consonant-vowel monosyllable perception and word recognition after cochlear implantation in elderly Japanese patients 査読

    Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

    ACTA OTO-LARYNGOLOGICA   135 ( 11 )   1108 - 1112   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Conclusion: Performance in consonant-vowel (CV) monosyllable speech perception after cochlear implantation (CI) in the elderly (&gt;= 65 years) is equivalent to that of young adults (18-64 years). Present data in the Japanese language supported the indication for CI in the elderly. Word recognition after CI was significantly lower in the elderly than young adults. Objective: This study compared outcomes of monosyllable perception and word recognition after CI between elderly patients and young adults with post-lingual deafness. Age-related differences in CV monosyllable speech perception in Japanese were examined. Methods: A retrospective chart review of 137 patients with post-lingual deafness who underwent CI at Okayama University Hospital during 1992-2014 [young adults aged 18-64 years (n = 96) and elderly aged &gt;= 65 years (n = 41) at implantation] was conducted. CV monosyllable speech perception post-CI was compared among age groups (18-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89). CV monosyllable perception and word recognition scores post-CI were compared between the elderly and young adults. Results: There was no significant difference in CV monosyllable speech perception among age groups. CV monosyllable speech perception in the elderly (61.4 +/- 25.5%) did not differ from that of young adults (65.9 +/- 24.8%). Word recognition scores were significantly lower in the elderly (64.3 +/- 28.1%) than young adults (80.4 +/- 25.9%) (p &lt; 0.05).

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  • 2年以上聴力経過を観察した小児心因性難聴の7例

    前田 幸英, 片岡 祐子, 菅谷 明子, 長安 吏江, 中川 敦子, 假谷 伸, 西﨑 和則

    AUDIOLOGY JAPAN   58 ( 5 )   335 - 336   2015年

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    記述言語:日本語   出版者・発行元:日本聴覚医学会  

    DOI: 10.4295/audiology.58.335

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  • 当科で経験したBOR症候群の2家族例

    浦口 健介, 菅谷 明子, 片岡 祐子, 前田 幸英, 假谷 伸, 福島 邦博, 西崎 和則

    Otology Japan   24 ( 4 )   548 - 548   2014年9月

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    記述言語:日本語   出版者・発行元:(一社)日本耳科学会  

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  • Assessment of hearing aid outcome using CADL 査読

    Rie Nagayasu, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Kunihiro Fukushima, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   117 ( 8 )   1126 - 1131   2014年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    The presence of hearing impairment deteriorates patients' quality of life by affecting their daily-life communication. Several self-report assessments are available to evaluate the subjective outcome of hearing aids, however, the procedures to evaluate the impairment of communication induced by hearing impairment has not been well established. A PC-recorded audio file prepared to evaluate the communication ability of hearing aid users, by extracting fifteen spoken language items from the Communication ADL Test: sp-CADL. A before and after study was performed among the hearing aid users who were attending Okayama University Hospital to evaluate the improvement in each of the 15 sp-CADL scores. Twenty-one adults were included in this study whose age ranged from 22 to 83 years old (mean: 56.7 years old). The total and individual scores of the sp-CADL improved significantly after the use of the hearing aids (p &gt
    0.05). The total sp-CADL score of the patients with hearing aids showed a good correlation with the best scores of the speech discrimination test measured before wearing hearing aids. CADL may be used for measuring communicative outcomes in patients using hearing aids.

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  • Effectiveness of Domain-Based Intervention for Language Development in Japanese Hearing-Impaired Children: A Multicenter Study 査読

    Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Toshiyuki Ojima, Goro Takahashi, Takashi Nakagawa, Seiko Murai, Yasoichi Nakajima, Kazunori Nishizaki

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   123 ( 7 )   500 - 508   2014年7月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS INC  

    Objective: Decreasing language delay in hearing-impaired children is a key issue in the maintenance of their quality of life. Language training has been presented mainly by experience-based training; effective intervention programs are crucially important for their future. The aim of this study was to confirm the efficacy of 6-month domain-based language training of school-age, severe-to-profound hearing-impaired children.
    Methods: We conducted a controlled before-after study involving 728 severe-to-profound prelingual hearing-impaired children, including an intervention group (n = 60), control group (n = 30), and baseline study group (n = 638). Language scores of the participants and questionnaires to the caregivers/therapists were compared before and after the intervention. Average monthly increase in each language score of the control group and baseline study group were compared with those of the intervention group.
    Results: Language scores and the results of the questionnaire of the intervention group showed a significant improvement (P &lt; .05). The average monthly language growth of the intervention group was twice that of the control group and 3 to 4 times that of the baseline study group (P &lt; .05). The effect size was largest in communication (1.914), followed by syntax (0.931).
    Conclusion: Domain-based language training improved the language development and daily communication of hearing-impaired children without any adverse effects.

    DOI: 10.1177/0003489414525023

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  • The age at which the grade of Special Child Dependent's Allowance Act can be judged in the case of deaf children. 査読

    Kataoka Y, Fukushima K, Sugaya A, Maeda Y, Nishizaki K

    Nihon Jibiinkoka Gakkai Kaiho   117 ( 9 )   1200 - 4   2014年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery 査読

    Yuko Kataoka, Tetsuo Ikezono, Kunihiro Fukushima, Koji Yuen, Yukihide Maeda, Akiko Sugaya, Kazunori Nishizaki

    AURIS NASUS LARYNX   40 ( 4 )   422 - 424   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Perilymphatic fistula (PLF) is defined as an abnormal leakage between perilymph from the labyrinth to the middle ear. Symptoms include hearing loss, tinnitus, and vertigo. The standard mode of PLF detection is intraoperative visualization of perilymph leakage and fistula, which ostensibly confirms the existence of PLF. Other possible methods of diagnosis include confirmation of pneumolabyrinth via diagnostic imaging. Recently, a cochlin-tomoprotein (CTP) detection test has been developed that allows definitive diagnosis of PLF-related hearing loss.
    We report the case of a 45-year-old man who presented with right-sided tinnitus, hearing loss, and dizziness 30 years after stapes surgery. Middle ear lavage was performed after myringotomy. A preoperative diagnosis of PLF was reached using the CTP detection test. Intraoperative observations included a necrotic long process of the incus, displaced wire piston, and fibrous tissue in the oval window. Perilymph leakage was not evident. The oval window was closed with fascia, and vertigo disappeared within 2 weeks postoperatively. When PLF is suspected after stapes surgery, the CTP detection test can be a useful, highly sensitive, and less invasive method for preoperative diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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  • Syntactic Development in Japanese Hearing-Impaired Children 査読

    Akie Fujiyoshi, Kunihiro Fukushima, Tomoko Taguchi, Kana Omori, Norio Kasai, Shinya Nishio, Akiko Sugaya, Rie Nagayasu, Takayuki Konishi, Syuuhei Sugishita, Jyunpei Fujita, Kazunori Nishizaki, Masae Shiroma

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   121 ( 4 )   28 - 34   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ANNALS PUBL CO  

    Objectives: This study examined syntactic development of auditory comprehension of sentences in Japanese-speaking school-age children with and without hearing impairment.
    Methods: In total, 592 preschool and school-age children (421 normal-hearing and 171 hearing-impaired) were included in this cross-sectional observation study conducted using the Syntactic Processing Test for Aphasia for Japanese language users. Linear regression analysis was used to determine the estimated age at which each syntactic structure was acquired.
    Results: Acquisition of syntactic structures was observed in hearing-impaired and normal-hearing children. Basic word order sentences of agent-object-verb and the goal benefactive construction were acquired at preschool age (earlier group), whereas reverse word order sentences of object-agent-verb, source benefactive construction, passive voice, and relative clauses were acquired at school age (later group). The results showed that many hearing-impaired children may not acquire Japanese grammatical structures until the age of 12 years.
    Conclusions: Adequate screening for language development for school-age hearing-impaired children is required for an effective intervention.

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  • Language Ability in the Intermediate-Scoring Group of Hearing-Impaired Children 査読

    Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Akie Fujiyoshi, Tomoko Taguchi, Kana Omori, Toshiyuki Ojima, Kazunori Nishizaki

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   121 ( 4 )   21 - 27   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ANNALS PUBL CO  

    Objectives: Language development is a key issue in hearing-impaired children. However, interpersonal differences complicate our understanding of the situation. The bimodal or trimodal distribution of language scores in our other reports in this publication imply the presence of fundamental differences among these groups. The characteristic aspects of each group were profiled according to language data.
    Methods: We divided 268 children with prelingual severe to profound hearing impairment into 3 groups according to their trimodal distribution observed on histogram-based analysis of their responses to the Test of Question-Answer Interaction Development. Test results in several language domains, including productive and comprehensive vocabulary, productive and comprehensive syntax, and academic achievement, were profiled and compared among these 3 groups.
    Results: Significant differences were observed in the results of the Word Fluency Test, the Picture Vocabulary Test Revised, and the Syntax Test of Aphasia among the 3 groups. No significant difference was observed between groups who were lower-scoring and intermediate-scoring on the academic achievement tests referred to as Criterion Referenced Test II and the Standardized Comprehension Test for Abstract Words. Only the higher-scoring group showed excellent results. The demographic factors were not significantly different among the 3 groups.
    Conclusions: Relatively poor academic achievement despite fair language production was the dominant feature of the intermediate-scoring group. This profile might correlate with academic failure in school.

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  • Effects of Early Identification and Intervention on Language Development in Japanese Children With Prelingual Severe to Profound Hearing Impairment 査読

    Norio Kasai, Kunihiro Fukushima, Kana Omori, Akiko Sugaya, Toshiyuki Ojima

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   121 ( 4 )   16 - 20   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ANNALS PUBL CO  

    Objectives: Early identification and intervention for prelingual bilateral severe to profound hearing loss is supposed to reduce the delay in language development. Many countries have implemented early detection and hearing intervention and conducted regional universal newborn hearing screening (UNHS). However, the benefits of UNHS in later childhood have not yet been confirmed, although language development at school age has a lifelong impact on children's future. Our Research on Sensory and Communicative Disorders project attempted to reveal the effects of UNHS and those of early intervention on the development of verbal communication in Japanese children.
    Methods: In this study, 319 children with prelingual bilateral severe to profound hearing loss, 4 to 10 years of age, were evaluated with the Test of Question-Answer Interaction Development used as an objective variable. Participation in UNHS and early intervention were used as explanatory variables. The adjusted odds ratio (AOR) was calculated after adjusting several confounding factors with use of logistic regression analysis. In addition, caregivers' answers were obtained by a questionnaire, and the process of diagnosis with and without UNHS was analyzed retrospectively.
    Results: Early intervention was significantly associated with better language development (AOR, 3.23; p &lt; 0.01). Participation in UN HS may contribute to better language development to some extent (AOR, 1.32), but not one that was statistically significant (p = 0.37). However, UNHS was significantly associated with early intervention (AOR, 20.21; p &lt; 0.001). The questionnaire results indicated a lag in treatment after UNHS in more than 40% of screened cases.
    Conclusions: Early intervention strongly influenced language development. It is necessary to ensure that early identification leads directly to early intervention.

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  • Assessment Package for Language Development in Japanese Hearing-Impaired Children (ALADJIN) as a Test Battery for the Development of Practical Communication 査読

    Kunihiro Fukushima, Norio Kasai, Kana Omori, Akiko Sugaya, Akie Fujiyoshi, Tomoko Taguchi, Takayuki Konishi, Syuuhei Sugishita, Wataru Takei, Hiroshi Fujino, Toshiyuki Ojima, Kazunori Nishizaki

    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY   121 ( 4 )   3 - 15   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ANNALS PUBL CO  

    Objectives: The measurement of language development in hearing-impaired children is an important step in assessing the appropriateness of an intervention. We proposed a set of language tests (the Assessment Package for Language Development in Japanese Hearing-Tmpaired Children [ALADJIN]) to evaluate the development of practical communication skills. This package consisted of communication skills (TQAID), comprehensive (PVT-R and SCTAW) and productive vocabulary (WFT), comprehensive and productive syntax (STA), and the STRAW.
    Methods: A total of 638 children with greater than 70-dB hearing impairment were subjected to this set of language tests. Additional tests, including the PARS, the RCPM, and parental questionnaires, were administered to assess the backgrounds of the children.
    Results: A trimodal distribution was observed among hearing-impaired children by the histogram-based analysis of each test.
    Conclusions: The ALADJIN is a useful Japanese-language evaluation kit for hearing-impaired children.

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  • 生後11ヶ月で人工内耳埋込術を施行した細菌性髄膜炎後難聴の1例 査読

    濱田 浩司, 菅谷 明子, 片岡 祐子, 前田 幸英, 福島 邦博, 西崎 和則

    小児耳鼻咽喉科   33 ( 1 )   23 - 28   2012年3月

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    記述言語:日本語   出版者・発行元:Japan Society for Pediatric Otorhinolaryngology  

    生後11ヶ月で人工内耳埋込術を施行した髄膜炎後難聴の 1 例を経験したので報告する。症例は生後 8 ヶ月で,細菌性髄膜炎に罹患し,治癒後の聴性脳幹反応検査では両側 105 dBnHL で反応がみられなかった。内耳 MRI の 3D 再構築画像で右内耳は既に閉塞し,内耳内腔の骨化が急速に進行していると考えられた。左内耳は今後閉塞が高度となる可能性が考えられ,直ちに左人工内耳埋込術を施行した。髄膜炎後の難聴にはしばしば蝸牛内骨化を伴うが,中には髄膜炎罹患後約 2 週間から内耳骨化が進行するような,急速な骨化例もある。髄膜炎直後の乳児では難聴の早期発見のための ABR 検査や,難聴の存在を疑われた場合の迅速な MRI 検査は不可欠である。

    DOI: 10.11374/shonijibi.33.23

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  • 当院における再手術・追加手術を要した小児の人工内耳症例5例の検討 査読

    菅谷 明子, 福島 邦博, 片岡 祐子, 前田 幸英, 笠井 紀夫, 平井 美紗都, 長安 吏江, 西崎 和則

    小児耳鼻咽喉科   32 ( 3 )   409 - 414   2011年12月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:Japan Society for Pediatric Otorhinolaryngology  

    一般的には人工内耳術後再手術の適応には,機器の故障,血腫の形成,創部感染,および電極の位置不良などが挙げられる。また最近の手術時年齢の低下からは,耳管機能の未熟さに伴い,経過中に中耳疾患を合併することも少なくない。<br/>  今回当院で実施した小児の人工内耳埋め込み術150例のうち再手術を要した 3 例および追加手術を要した 2 例について検討した。再手術の 3 例は全員機器不良によるものであり,同側の人工内耳 explant/implant 術を施行した。また,追加手術の 2 例では鼓膜換気チューブ留置術および鼓膜形成術を施行した。このうち外傷後に再手術を行った内耳奇形の 1 例の詳細を報告した。<br/>  再手術を要する症例では失聴期間をできるだけ短くするために迅速な対応を行い,術側の決定および術中の電極の位置確認を慎重に行うことが重要であると考える。

    DOI: 10.11374/shonijibi.32.409

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  • Expression analysis of microRNAs in murine cochlear explants 査読

    Misato Hirai, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Yuko Kataoka, Kazunori Nishizaki

    NEUROREPORT   22 ( 13 )   652 - 654   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    MicroRNAs (miRNAs) play functional roles in sound transduction in cochlea. This study focuses on the validity of cochlear culture as an in vitro experimental tool, in view of miRNA expression. E15 cochleae were dissected and maintained in vitro for 48 h before extraction of miRNAs. MiRNA expression was comprehensively screened in explanted cochleae using a miRNA array that covers 380 miRNAs. A strong correlation was observed between expression levels of miRNAs in in vitro and in in vivo cochleae. Levels of 43 miRNAs were altered in vitro and these changes were reproducible over three trials. These findings indicate that in vitro miRNA profiling is a viable method for analysis of gene expression and action of chemical compounds on cochleae. NeuroReport 22:652-654 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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  • Orbital Emphysema Causing Syncope 査読

    Kentaroh Miki, Yorihisa Orita, Fumiaki Kumase, Akiko Sugaya, Misato Hirai, Yasuyuki Noyama, Kiyoko Nakai, Akiko Narita, Jiroh Seguchi

    ACTA MEDICA OKAYAMA   65 ( 1 )   55 - 57   2011年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Orbital emphysema is an abnormal condition in which air is present within the orbit. We report a rare case of a 19-year-old man who suffered syncopic attacks caused by sniffles following orbital emphysema as a result of trauma. Treating rhinitis is important in patients with orbital emphysema, and patients with cardiac disorders in addition to those with this condition must be warned about the risks of sniffles, sneezing, or nose blowing.

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  • Subsidizing hearing aid purchase in mild to moderate pediatric hearing - Pediatric status following prefectural assembly subvention 査読

    Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Yu Masuda, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   114 ( 8 )   731 - 736   2011年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    The dissemination of newborn hearing screening (NHS) has enabled those with mild to moderate hearing loss to be diagnosed in early infancy. The "handicapped independence support law", however, prevents those not determined to be physically handicapped,-i.e., those with mild to moderate hearing loss-, from government assistance in purchasing hearing aids. This results either in (i) parents purchasing hearing aids at their own expense or (ii) nonpurchase of hearing aids. To redress this situation, subvention in purchasing hearing aids of mild to moderate hearing loss children has been begun by some local governments. We petitioned for such aid at the Okayama Prefecture Assembly. A society for supporting pediatric hearing difficulty in Okayama Prefecture also submitted a similar petition in September 2009, and subvention began in April 2010 for all such children in Okayama Prefecture. We report procedures and details leading to this subvention.

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  • Progressive or delayed early-onset pediatric sensorineural hearing loss 査読

    Yuko Kataoka, Kunihiro Fukushima, Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Yu Masuda, Kazunori Nishizaki

    Journal of Otolaryngology of Japan   114 ( 6 )   557 - 561   2011年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oto-Rhino-Laryngological Society of Japan Inc.  

    The introduction of newborn-hearing screening has enabled early childhood hearing loss to be diagnosed and increased the number of children undergoing early care. Bilateral hearing loss is found in 0.08% of newborns and children whose hearing loss progresses or onset is delayed account for 4 to 30% of all pediatric hearing impairment. Children with perinatal risk factors tend to have deteriorated hearing or delayed-onset hearing loss in early childhood, necessitating audiometric follow-up. We also are aware of some children without risk factors who develop hearing impairment during infancy or early childhood. Hearing deterioration may be difficult to diagnose objectively, especially in young children, the presence of risk factors must be determines as soon as possible, especially given the lack of hearing management and close examination of children without apparent risk factors. We retrospectively studied children born from April 1998 to March 2007 and undergoing cochlear implantation as of April 2008. Among cases, we focused on 10 whose hearing impairment advanced during infancy-4 with risk factors known before hearing deterioration progressed, and 6 cases thought not to have any risk factors. We detected enlarged vestibular acquaducl in 3 of these 6 cases, and 3 more of whom had no risk factors-2 passing newborn-hearing screening and 1 in whom such screening detected hemilateral hearing loss. Our results underscore the need for early temporal computed tomography for detecting enlarged vestibular aquaduct. Even children with mild or hemilateral hearing loss should undergo audiometric and developmental testing at least every 6 months up to going to elementary school. Children suspected of impaired hearing should undergo thorough hearing tests regardless of newborn hearing-screening results to catch any problems early. Appropriate regular hearing and language development check-up tests must also be developed.

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  • 耳下腺深葉に発生したオンコサイトーマの1例

    三木 健太郎, 折田 頼尚, 菅谷 明子, 平井 美紗都, 中井 貴世子, 能勢 聡一郎

    口腔・咽頭科 = Stomato-pharyngology   23 ( 2 )   237 - 241   2010年6月

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    記述言語:日本語   出版者・発行元:日本口腔・咽頭科学会  

    耳下腺深葉に発生したオンコサイトーマの症例を報告する. 症例は64歳の男性. 左耳下部の腫脹にて受診し, 画像検査などにて耳下腺深葉腫瘍が疑われ, 腫瘍摘出術が施行された. 病理検査にてオンコサイトーマと診断され, 非常に稀な腫瘍型であるため, 若干の文献的考察を加え報告した.

    DOI: 10.14821/stomatopharyngology.23.237

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  • Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland 査読

    Yorihisa Orita, Kazuo Hamaya, Kentaroh Miki, Akiko Sugaya, Misato Hirai, Kiyoko Nakai, Sohichiroh Nose, Tadashi Yoshino

    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY   267 ( 5 )   801 - 806   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The occasional local recurrence of benign pleomorphic adenoma (PA) has generally been attributed to the vulnerability of the tumor capsule. Although some reports have also noted the presence of satellite tumors associated with PA recurrence, only few reports have focused on this issue. We paid special attention to the satellite lesions apart from the main tumors and discussed their frequency, origin, nature and the ways of treating them. A total of 108 specimens of primary parotid gland PA resected at the Okayama Saiseikai General Hospital from 1988 to 2008 were microscopically reviewed. Four (3.7%) patients displayed a main mass with satellite tumors in a single parotid gland. The immunohistochemical analysis of p53 and Ki-67 index showed no distinct difference between PAs with satellite tumors and those without. Satellite tumors surrounding the main mass of parotid PA is relatively rare. In most cases, such satellite tumors will arise from capsular perforation of the primary tumor cells. Preoperative evaluation to recognize the existence of satellite tumors would be important and capsular dissection should be discouraged. We could not find any evidence suggesting that primary PA with satellite tumors could be more biologically aggressive than those without.

    DOI: 10.1007/s00405-009-1149-7

    Web of Science

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  • Large cerebellar arteriovenous malformation with dizziness 査読

    Misato Hirai, Yorihisa Orita, Akiko Sugaya, Kazunori Seno, Koji Yuen

    Practica Oto-Rhino-Laryngologica   101 ( 10 )   759 - 764   2008年

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    掲載種別:研究論文(学術雑誌)  

    We report a 21-year-old female who complained of dizziness with cerebellar arteriovenous malformation (AVM). At her first visit, she complained only of dizziness and did not show any other cranial nerve symptoms. She was therefore diagnosed with peripheral vertigo and started treatments. Two weeks after the first examination, she was examined by electronystagmograph (ENG) because her dizziness had not improved. The ENG result suggested that the dizziness was caused by a central lesion disorder and a MRI scan revealed a large AVM in the cerebellum and brainstem. Although AVM commonly shows cerebral hemorrhage or convulsion as the first symptom, we experienced a case of AVM with only mild symptoms of dizziness and headache.

    DOI: 10.5631/jibirin.101.759

    Scopus

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▼全件表示

書籍等出版物

  • 耳鼻咽喉科日常検査リファレンスブック

    中川 尚志( 範囲: 乳幼児聴力検査)

    中山書店  2024年5月  ( ISBN:9784521749532

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    総ページ数:xv, 497p   記述言語:日本語

    CiNii Books

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  • こどもの難聴診療マニュアル

    福島, 邦博, 神田, 幸彦( 範囲: 新生児聴覚スクリーニングの実際 環境調整指導のポイント)

    日本医事新報社  2024年3月  ( ISBN:9784784924776

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    総ページ数:262p   記述言語:日本語

    CiNii Books

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  • 人工内耳が感染を起こした場合、どの様に対処しますか?

    東京医学社  2016年 

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  • 普通学校(メインストリーム)における教育

    菅谷明子( 担当: 共著)

    診断と治療社  2014年 

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MISC

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講演・口頭発表等

  • Symposium 1:今から始めるこどもから大人への移行支援 招待

    菅谷 明子

    第18回 日本小児耳鼻咽喉科学会 総会・学術講演会  2023年11月9日 

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    開催年月日: 2023年11月9日 - 2023年11月10日

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  • 知ってますか?難聴の原因と対策

    菅谷明子

    コクレア市民公開講座  2024年7月7日 

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  • 岡山大学病院の人工内耳医療 -手術の実際と当科の取り組みについて-

    菅谷明子

    岡山県耳鼻咽喉科領域講習オンラインセミナー  2022年9月22日 

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  • 日常診療で遭遇する中耳炎の 診断と治療 -難聴との関連も含めて-

    菅谷明子

    Kyorin耳鼻咽喉科WEBセミナー  2022年7月5日 

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  • 人工内耳装用者の生涯にわたるサポートの重要性 -就労支援について-

    菅谷明子

    第6回人工内耳友の会ACITA岡山支部総会  2022年5月22日 

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  • 人工内耳について学ぶ

    菅谷明子

    岡山県聴覚障害者関係地域ボランティア研修会  2022年5月21日 

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  • カタカナ書字困難に対する介入を行った軽度難聴児の1例

    菅谷 明子

    第120回 日本耳鼻咽喉科学会総会・学術講演会  2019年 

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  • 異なる聴力像を示したGJB2遺伝子変異による難聴の双胎児例

    菅谷 明子

    第64回 日本聴覚医学会  2019年 

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  • 小児における人工内耳術後のマッピング開始時期の検討

    菅谷 明子

    第63回 日本聴覚医学会  2018年 

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  • 新生児聴覚スクリーニング実施における費用対策効果の検討

    第118回日本耳鼻咽喉科学会通常総会・学術講演会  2017年 

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  • デキサメタゾン投与後の蝸牛遺伝子発現パターンの経時的・動態的検討

    第118回日本耳鼻咽喉科学会通常総会・学術講演会  2017年 

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  • 中耳炎により外科的処置を要した小児人工内耳装用例の検討

    第12回日本小児耳鼻咽喉科学会総会・学術講演会  2017年 

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  • 次世代シークエンサー(NGS)を併用した難聴遺伝子検査が有用であった3例

    第41回日本遺伝カウンセリング学会  2017年 

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  • めまいを伴いVZV陽性の小児急性感音難聴の1例

    第17回岡山県地方部会学術講演会  2017年 

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  • MRI検査後に人工内耳インプラントのマグネットの反転を来たした2例

    菅谷明子

    2016年 

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  • 急性感音難聴モデルマウスへのステロイド投与後の内耳遺伝子発現 - RNA-seqとDNAマイクロアレイを用いた解析 -

    第26回日本耳科学会総会・学術講演会  2016年 

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  • 初回手術後に長期間経過して対側人工内耳埋込術を施行された高度感音難聴児6例の検討

    第117回日本耳鼻咽喉科学会総会  2016年 

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  • 人工内耳装用前の早期補聴が言語発達に与える効果の検証

    第11回 日本小児耳鼻咽喉科学会  2016年 

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  • “高齢者の会話の聞き取り困難”と中枢聴覚機能検査について

    日本耳鼻咽喉科学会第42回中国四国地方部会連合学会  2016年 

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  • 頸部リンパ管腫に合併した滲出性中耳炎の1例

    第78回耳鼻咽喉科臨床学会総会および学術講演会  2016年 

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  • 岡山県における小児難聴例の診断時期の検討

    第11回 日本小児耳鼻咽喉科学会  2016年 

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  • 人工内耳装用児の英語学習における実態調査

    第26回日本耳科学会総会・学術講演会  2016年 

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  • 次世代シークエンサー を併用した難聴遺伝子検査が有用であった2例

    第42回 中国地方部会連合講演会  2016年 

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  • 両側高度難聴・前庭機能廃絶をきたした中枢神経原発リンパ腫の1症例

    第42回 中国地方部会連合講演会  2016年 

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  • 当科で経過を観察した両側聴神経鞘腫の2例

    第16回岡山県地方部会学術講演会  2016年 

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  • 純音聴力閾値上昇を呈した聴覚情報処理障害の小児例

    第117回日本耳鼻咽喉科学会総会  2016年 

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  • 乳幼児鼓膜インピーダンス測定における1000Hz tympanometryの有用性の検討

    第26回日本耳科学会総会・学術講演会  2016年 

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  • 当科における成人人工内耳症例の検討 - 埋め込み時65歳以上の術後成績について -

    第116回日本耳鼻咽喉科学会総会  2015年 

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  • 当科における小児の両側人工内耳症例50例の検討

    第10回日本小児耳鼻咽喉科学会総会・学術講演会  2015年 

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  • 難聴遺伝子診断と人工内耳

    平成26年度難聴遺伝子の研究会  2015年 

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  • 成人人工内耳装用者のピッチ弁別 およびプロソディーによる感情理解に関する研究

    第25回日本耳科学会総会・学術講演会  2015年 

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  • 人工内耳埋め込み術を施行した Waardenburg 症候群の 2 例

    第10回日本小児耳鼻咽喉科学会総会・学術講演会  2015年 

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  • 言語評価の後に補聴器装用・言語訓練の開始に至った中等度難聴の一例

    第10回日本小児耳鼻咽喉科学会総会・学術講演会  2015年 

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  • 当科における急性低音障害型感音難聴の治療と予後の検討

    第116回日本耳鼻咽喉科学会総会  2015年 

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  • 岡山県内胃瘻造設術施行施設へのアンケートからみる嚥下機能評価における耳鼻咽喉科医の役割

    第116回日本耳鼻咽喉科学会総会  2015年 

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  • 複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリングの経験

    第39回日本遺伝カウンセリング学会  2015年 

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  • 蝸牛におけるステロイド作用機序 - Charcot-Marie-Tooth neuropathy関連蛋白, Myelin protein zeroの制御 -

    第25回日本耳科学会総会・学術講演会  2015年 

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  • 人工内耳装用者のスポーツ時における問題に関するアンケート調査

    第25回日本耳科学会総会・学術講演会  2015年 

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  • 再発性多発軟骨炎の2症例

    日本耳鼻咽喉科学会第41回中国地方部会連合講演会  2015年 

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  • 残存聴力活用型人工内耳(EAS : electric acoustic stimulation)が有効であった高音急墜型感音難聴の1例

    日本耳鼻咽喉科学会第41回中国地方部会連合講演会  2015年 

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  • 福山型先天性筋ジストロフィー患児に対する人工内耳埋め込み術

    第116回日本耳鼻咽喉科学会総会  2015年 

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  • 脳表ヘモジデリン沈着症に伴う進行性高度感音難聴に対し人工内耳埋め込み術を行い良好な経過を得た1例

    第77回耳鼻咽喉科臨床学会学術講演会  2015年 

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  • 成人期になり診断したAuditory Processing Disorderの1症例

    第25回日本耳科学会総会・学術講演会  2015年 

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  • 顔面神経麻痺, 感音難聴を呈した髄膜癌腫症の2例

    第25回日本耳科学会総会・学術講演会  2015年 

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  • 2年以上聴力経過を観察した小児心因性難聴の7例

    第60回日本聴覚医学会  2015年 

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  • 岡山県における軽度・中等度難聴児補聴器助成事業実施状況の検討

    第115回日本耳鼻咽喉科学会総会  2014年 

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  • 岡山大学耳鼻咽喉科における補聴器外来の現況-高齢者の補聴に関連して-

    第115回日本耳鼻咽喉科学会総会  2014年 

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  • 回転性めまい発作を呈した顔面神経鞘腫の1例

    日本耳鼻咽喉科学会第40回中国四国地方部会連合学会  2014年 

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  • 当科で経験したBOR症候群の家族例

    第38回日本遺伝カウンセリング学会  2014年 

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▼全件表示

共同研究・競争的資金等の研究

  • 音韻障害を合併した人工内耳装用児の早期診断および介入のための戦略

    研究課題/領域番号:24K12674  2024年04月 - 2027年03月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    菅谷 明子

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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  • 一側性聴覚障害の評価手法の標準化と社会参加を促進する手法に関する研究開発

    2024年04月 - 2027年03月

    日本医療研究開発機構 障害者対策総合研究開発事業

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    担当区分:研究分担者 

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  • 先天性および若年性の視覚聴覚二重障害の難病に対する医療と支援に関する研究

    2024年04月

    厚生労働科学研究費補助金 難治性疾患等政策研究事業

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    担当区分:研究分担者 

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  • 聴覚障害者の就労支援チェックリストに基づいた就労マッチング支援手法の開発 および遮音材・補聴援助システムによる住居支援の効果の検証

    研究課題/領域番号:23dk0310122h0001  2023年05月 - 2026年03月

    日本医療研究開発機構  AMED  身体・知的・感覚器障害分野(障害者対策総合研究開発事業)

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    担当区分:研究代表者 

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  • 聴覚障害者の社会参加を促進するための手法に関する研究

    2020年 - 2023年

    聴覚障害児・者の円滑な社会参加に資する施策立案に関する研究(AMED) 研究分担者 

    菅谷明子

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    担当区分:研究分担者 

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  • 急性感音難聴の病態と治療における内耳免疫メカニズム -内耳遺伝子転写網の解析-

    2019年04月 - 2022年03月

    科学研究費補助金(基盤C)研究分担者 

    前田幸英, 菅谷明子

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    担当区分:研究分担者  資金種別:競争的資金

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  • 難聴児における音韻障害の遺伝学的診断法と言語発達評価法の開発

    2018年04月 - 2021年03月

    科学研究費補助金(若手研究) 研究代表者 

    菅谷明子

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    担当区分:研究代表者  資金種別:競争的資金

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  • 「難治性聴覚障害に関する調査研究班」

    2017年04月 - 2020年03月

    厚生労働科学研究費補助金 難治性疾患等政策研究事業 研究協力者 

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    資金種別:競争的資金

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  • 原因診断に基づく小児難聴の治療・療育システム構築に関する研究

    2016年04月 - 2019年03月

    日本医療研究開発機構(AMED)  長寿・障害総合研究事業 障害者対策総合研究開発事業(研究分担者) 

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    担当区分:研究分担者  資金種別:競争的資金

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  • 急性感音難聴の分子病態と治療の動態的解析-次世代シークエンスでの統合遺伝子解析-

    2016年04月 - 2019年03月

    科学研究費補助金(基盤C)研究分担者 

    前田幸英, 菅谷明子

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    担当区分:研究分担者  資金種別:競争的資金

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  • 人工内耳装用児の英語学習における実態調査ならびに介入手法に関する研究

    2015年04月 - 2018年03月

    科学研究費補助金(若手研究B) 研究代表者 

    菅谷明子

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    担当区分:研究代表者  資金種別:競争的資金

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  • 乳幼児の疾患疫学を踏まえたスクリーニング等の効果的実施に関する研究

    2015年04月 - 2018年03月

    日本医療研究開発機構(AMED)(研究協力者) 

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    資金種別:競争的資金

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  • 乳幼児中耳貯留液の診断における1000Hzティンパノメトリーの有用性の検討

    2014年04月 - 2017年03月

    科学研究費補助金(基盤C)研究分担者 

    片岡祐子

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    資金種別:競争的資金

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  • 学習障害関連遺伝子をターゲットとした人工内耳予後予測因子に関する研究

    研究課題/領域番号:25462641  2013年04月 - 2014年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    福島 邦博, 前田 幸英, 片岡 祐子, 菅谷 明子

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    担当区分:研究分担者 

    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    小児先天性難聴に対しては、現在人工内耳埋め込み術が早期(1歳前後)から適応されることが多くなっている。しかし、人工内耳装用児のすべてが順調な言語発達を示すとは限らず、その言語発達には個人差が大きい。特に低年齢の人工内耳装用児でその言語発達予後を予測することは容易ではなく、より適切な手法の開発が望まれている。遺伝子診断は、従来難聴の原因を探すために主として用いられてきたが、近年では学習障害などの原因遺伝子も明らかにされており、この技術を用いて人工内耳術後の言語発達予後予測を行うことをこの研究の目標とした。当面、その予備実験として難聴のない言語発達障害児童(特異的言語発達障害)において、既に海外で報告されている言語発達に影響を与える遺伝子での変異の有無を検討した。末梢血から採取したDNAを用い、パラレルシークエンス法によって候補遺伝子(FOXP2,DYA1C1,DCDC2, KIAA0319, ROBO1)の全エクソンにおける変異を検討した。意味のある変異を検出することはできなかった。日本語話者での遺伝子変異は人種的ないしは言語的な違いにより、欧米での遺伝子変異とパターンが異なる可能性があり、まず本邦患者を元にした新たな言語発達障害関連遺伝子の解析が望まれると考えられた。

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  • 聴覚障害児の言語リハビリ長期予後に関する追跡調査

    2013年04月 - 2014年03月

    厚生労働省科学研究費補助金(研究協力者) 

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    資金種別:競争的資金

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  • 「感覚器障害戦略研究(聴覚分野)」

    2010年04月 - 2012年03月

    厚生労働省科学研究費補助金 (研究協力者) 

    福島邦博、菅谷明子

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    資金種別:競争的資金

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▼全件表示

 

担当授業科目

  • 耳鼻咽喉科学 (2023年度) 第2学期  - 木3

 

社会貢献活動

  • 大元寮診療所 岡山かなりや学園 嘱託医

    役割:運営参加・支援

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  • 岡山県身体障害者更生相談所 判定医

    役割:助言・指導

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