Faculty Profiles - SUGAYA AKIKO

写真a

SUGAYA AKIKO

Organization

Faculty of Medicine, Dentistry and Pharmaceutical Sciences Lecturer

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Degree

PhD ( 2014.6 Okayama University )

Research Interests

人類遺伝学
小児難聴
言語発達
耳科学
人工内耳

Research Areas

Life Science / Otorhinolaryngology

Education

Okayama University 医学研究科 (博士課程：耳鼻咽喉科学）

- 2014

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Okayama University 医学部医学科

- 2003

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Research History

岡山大学学術研究院医歯薬学域講師

2024.8

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Okayama University 耳鼻咽喉・頭頸部外科 Assistant Professor

2017.4 - 2024.7

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Okayama University 耳鼻咽喉科

2010.4 - 2017.3

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岡山済生会総合病院

2007.6 - 2010.3

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広島市立広島市民病院

2005.4 - 2007.5

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Professional Memberships

日本遺伝カウンセリング学会

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日本耳科学会

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日本耳鼻咽喉科頭頸部外科学会

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Committee Memberships

小児難聴相談医ワーキンググループ

2023.11

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日本耳鼻咽喉科頭頸部外科学会乳幼児医療委員会

2020.6

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Committee type：Academic society

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Papers

Potential for Radiation Dose Reduction in Temporal Bone CT Imaging Using Photon-Counting Detector CT.

Fumiyo Higaki, Yusuke Morimitsu, Toshihiro Iguchi, Sung Il Hwang, Takahiro Kitayama, Yuka Takahashi, Mayu Uka, Noriaki Akagi, Akiko Sugaya, Toshiharu Mitsuhashi, Yusuke Matsui, Takao Hiraki

Acta medica Okayama 79 ( 2 ) 75 - 80 2025.4

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Language：English Publishing type：Research paper (scientific journal)

Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%.

DOI： 10.18926/AMO/68645

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Three Cases of BONEBRIDGE Implantation at Okayama University Hospital

Akiko Sugaya, Shin Kariya

The Japan Journal of Logopedics and Phoniatrics 66 ( 2 ) 99 - 106 2025.4

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Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Logopedics and Phoniatrics

DOI： 10.5112/jjlp.66.99

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Short-process incudo-stapedioplasty in congenital ear malformation. International journal

Ryotaro Omichi, Shin Kariya, Akiko Sugaya, Mizuo Ando

Laryngoscope investigative otolaryngology 10 ( 1 ) e70055 2025.2

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OBJECTIVES: Although various stapedotomy and stapedectomy techniques exist, anchoring the piston can be challenging. We present a novel surgical approach for treating congenital stapes malformations with an atypical facial nerve trajectory. METHODS: This is a case of a 7-year-old boy presenting with bilateral conductive hearing loss. Prior attempts at tympanoplasty had proven unsuccessful in improving his hearing. Presurgical imaging studies revealed an unusual anatomical configuration, with the facial nerve positioned inferior to the oval window. This anatomical variation precluded the use of conventional prosthesis-anchoring techniques typically employed in stapedotomies. Thus, we devised an innovative approach, opting to anchor the prosthesis to the short process of the incus. RESULTS: This novel technique circumvented the atypical course of the facial nerve, allowing for successful reconstruction of the ossicular chain. The patient demonstrated an acceptable improvement (30 dB gain) in hearing 1-year post-surgery, with no reported complications. CONCLUSION: This case underscores the critical importance of adapting surgical techniques to address the unique anatomical challenges that may arise in the context of congenital ear malformations. It also highlights the potential of the short process of the incus as a viable alternative anchoring site for stapes prostheses, thereby improving the outcomes of such complex cases. This technique not only restored the patient's hearing but also contributed valuable insights into the management of similar cases, potentially improving the quality of life for individuals with rare and challenging anatomical variations. LEVEL OF EVIDENCE: 5.

DOI： 10.1002/lio2.70055

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Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss. Reviewed

Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 349 - 355 2024.8

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment.

DOI： 10.18926/AMO/67554

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『今から始めるこどもから大人への移行支援』難聴児のスキル獲得のための多職種連携支援について考える Invited Reviewed

菅谷明子

小児耳鼻咽喉科 45 ( 1 ) 10 - 14 2024.6

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Authorship：Lead author Language：Japanese Publisher：日本小児耳鼻咽喉科学会

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The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B. International journal

Kizuki Watanabe, Shin-Ya Nishio, Shin-Ichi Usami

Scientific reports 14 ( 1 ) 8326 - 8326 2024.4

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The MYO7A gene is known to be responsible for both syndromic hearing loss (Usher syndrome type1B:USH1B) and non-syndromic hearing loss including autosomal dominant and autosomal recessive inheritance (DFNA11, DFNB2). However, the prevalence and detailed clinical features of MYO7A-associated hearing loss across a large population remain unclear. In this study, we conducted next-generation sequencing analysis for a large cohort of 10,042 Japanese hearing loss patients. As a result, 137 patients were identified with MYO7A-associated hearing loss so that the prevalence among Japanese hearing loss patients was 1.36%. We identified 70 disease-causing candidate variants in this study, with 36 of them being novel variants. All variants identified in autosomal dominant cases were missense or in-frame deletion variants. Among the autosomal recessive cases, all patients had at least one missense variant. On the other hand, in patients with Usher syndrome, almost half of the patients carried biallelic null variants (nonsense, splicing, and frameshift variants). Most of the autosomal dominant cases showed late-onset progressive hearing loss. On the other hand, cases with autosomal recessive inheritance or Usher syndrome showed congenital or early-onset hearing loss. The visual symptoms in the Usher syndrome cases developed between age 5-15, and the condition was diagnosed at about 6-15 years of age.

DOI： 10.1038/s41598-024-57415-1

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中耳炎様所見で発症し内耳窓閉鎖術を施行した外リンパ瘻2例の検討

菅谷明子, 假谷伸, 大道亮太郎, 片岡祐子, 前田幸英, 安藤瑞生

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 4 ) 600 - 600 2024.4

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Language：Japanese Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会

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市民公開講座参加者における聴力像の実際

浜本真一, 假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生, 原浩貴

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 4 ) 549 - 549 2024.4

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Language：Japanese Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会

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Cochlear Implantation in the Poorer-Hearing Ear Is a Reasonable Choice. Reviewed

Ryotaro Omichi, Shin Kariya, Yukihide Maeda, Kunihiro Fukushima, Yuko Kataoka, Akiko Sugaya, Kazunori Nishizaki, Mizuo Ando

Acta medica Okayama 77 ( 6 ) 589 - 593 2023.12

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Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of 'better-hearing ear' was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient's age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and -0.33, 95% confidence intervals [11.75-37.45] and [-0.58 to -0.09], respectively), but the CI surgery side did not (-6.76, [-14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing.

DOI： 10.18926/AMO/66150

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突発性難聴治療に対する新型コロナウイルス感染症の影響

大道亮太郎, 佐藤明日香, 菅谷明子, 前田幸英, 片岡祐子, 安藤瑞生

日本耳科学会総会・学術講演会抄録集 33回 260 - 260 2023.11

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Language：Japanese Publisher：(一社)日本耳科学会

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切除不能中耳粘膜悪性黒色腫に対して陽子線治療及びニボルマブ投与を実施した一例

佐藤明日香, 安藤瑞生, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 大道亮太郎

日本耳科学会総会・学術講演会抄録集 33回 314 - 314 2023.11

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Language：Japanese Publisher：(一社)日本耳科学会

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一般地域住民における難聴の実地調査難聴に関する公開講座参加者を対象に

浜本真一, 假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生, 原浩貴

日本耳科学会総会・学術講演会抄録集 33回 283 - 283 2023.11

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Language：Japanese Publisher：(一社)日本耳科学会

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Revision cochlear implant surgery in adults and children is a safe and effective technique: a retrospective single faculty study in Okayama University Hospital, Japan. Reviewed International journal

Akiko Sugaya, Shin Kariya, Kunihiro Fukushima, Ryotaro Omichi, Mizuo Ando

Acta oto-laryngologica 1 - 5 2023.10

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Cochlear implant (CI) surgery is a safe surgical technique, although some patients require revision CI surgery. AIMS/OBJECTIVES: This study investigated the cause and underlying reason of revision CI surgery as well as hearing outcomes in a single institution. PATIENTS AND METHODS: This retrospective study evaluated patients who underwent CI surgery between April 2006 to March 2022 (n = 351). Sex, aetiology of hearing loss (HL), age and period from initial CI surgery to reimplantation, cause of revision, and related factors were examined. RESULTS: Twelve patients (8 males, 4 females) received CI reimplantation. The revision surgery rate was 2.59% (3.15% children, 1.69% adults); the period from initial surgery to reoperation was 8.60 ± 6.56 years for 9 children with congenital HL and 15.27 ± 5.72 years for 3 adults with progressive HL. Device failure was the most common cause (n = 8), followed by infections (n = 2), advanced facial irritation symptoms (n = 1), and electrode slip-out (n = 1). Mean preoperative and postoperative CI thresholds were 44.0 ± 9.46 dBnHL and 39.19 ± 8.89 dBnHL (p < .068), respectively. CONCLUSION AND SIGNIFICANCE: Caregiver education, surgical technique advances, flap design, and extensive antibiotic use may decrease the revision surgery rate. The lack of post-revision deterioration of the hearing threshold contributed to well-being in patients with CI.

DOI： 10.1080/00016489.2023.2270701

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Evaluation of the ear ossicles with photon-counting detector CT. Reviewed

Yuka Takahashi, Fumiyo Higaki, Akiko Sugaya, Yudai Asano, Katsuhide Kojima, Yusuke Morimitsu, Noriaki Akagi, Toshihide Itoh, Yusuke Matsui, Takao Hiraki

Japanese journal of radiology 2023.8

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Recently, computed tomography with photon-counting detector (PCD-CT) has been developed to enable high-resolution imaging at a lower radiation dose. PCD-CT employs a photon-counting detector that can measure the number of incident X-ray photons and their energy. The newly released PCD-CT (NAEOTOM Alpha, Siemens Healthineers, Forchheim, Germany) has been in clinical use at our institution since December 2022. The PCD-CT offers several advantages over current state-of-the-art energy-integrating detector CT (EID-CT). The PCD-CT does not require septa to create a detector channel, while EID-CT does. Therefore, downsizing the anode to achieve higher resolution does not affect the dose efficiency of the PCD-CT. CT is an indispensable modality for evaluating ear ossicles. The ear ossicles and joints are clearly depicted by PCD-CT. In particular, the anterior and posterior legs of the stapes, which are sometimes unclear on conventional CT scans, can be clearly visualized. We present cases of congenital anomalies of the ossicular chain, ossicular chain dislocation, tympanosclerosis, and cholesteatoma in which PCD-CT was useful. This short article reports the usefulness of PCD-CT in the 3D visualization of the ear ossicles.

DOI： 10.1007/s11604-023-01485-0

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人工内耳装用児の術後コミュニケーション状態における術前CTによる前庭水管拡大症の影響の検討

菅谷明子, 假谷伸, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生

日本耳科学会総会・学術講演会抄録集 32回 342 - 342 2022.10

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Language：Japanese Publisher：(一社)日本耳科学会

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Cogan症候群に対して人工内耳植込術を施行した一例

佐藤明日香, 安藤瑞生, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 大道亮太郎

日本耳科学会総会・学術講演会抄録集 32回 271 - 271 2022.10

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Language：Japanese Publisher：(一社)日本耳科学会

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小児難聴と人工聴覚器

假谷伸, 菅谷明子, 片岡祐子

耳鼻咽喉科 2 ( 2 ) 263 - 269 2022.8

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Language：Japanese Publisher：(有)科学評論社

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Correction to: Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. Reviewed International journal

Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoshimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

Human genetics 141 ( 3-4 ) 993 - 995 2022.4

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Language：English

DOI： 10.1007/s00439-021-02392-y

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Etiology of hearing loss affects auditory skill development and vocabulary development in pediatric cochlear implantation cases. Reviewed International journal

Shin-Ya Nishio, Hideaki Moteki, Maiko Miyagawa, Tatsuya Yamasoba, Akinori Kashio, Satoshi Iwasaki, Masahiro Takahashi, Yasushi Naito, Keizo Fujiwara, Akiko Sugaya, Haruo Takahashi, Kyoko Kitaoka, Shin-Ichi Usami

Acta oto-laryngologica 142 ( 3-4 ) 308 - 315 2022

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BACKGROUND: Cochlear implantation (CI) is an effective treatment for severe-to-profound hearing loss patients and is currently used as the standard therapeutic option worldwide. However, the outcomes of CI vary among patients. AIMS/OBJECTIVES: This study aimed to clarify the clinical features for each etiological group as well as the effects of etiology on CI outcomes. MATERIALS AND METHODS: We collected clinical information for 308 pediatric cochlear implant cases, including the etiology, hearing thresholds, age at CI, early auditory skill development, total development, monosyllable perception, speech intelligibility and vocabulary development in school age, and compared them for each etiology group. RESULTS: Among the 308 CI children registered for this survey, the most common etiology of hearing loss was genetic causes. The genetic etiology group showed the most favorable development after CI followed by the unknown etiology group, syndromic hearing loss group, congenital CMV infection group, inner ear malformation group, and cochlear nerve deficiency group. CONCLUSIONS AND SIGNIFICANCE: Our results clearly indicated that the etiology of HL affects not only early auditory skill development, but also vocabulary development in school age. The results of the present study will aid in more appropriate CI outcome assessment and in more appropriate intervention or habilitation programs.

DOI： 10.1080/00016489.2022.2065027

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Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. Reviewed International journal

Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoishimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

Human genetics 141 ( 3-4 ) 865 - 875 2021.9

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Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype-phenotype correlation in patients with OTOF mutations is not yet fully understood. In this study, we aimed to reveal detailed clinical characteristics of OTOF-related hearing loss patients and the genotype-phenotype correlation. Detailed clinical information was available for 64 patients in our database who were diagnosed with OTOF-related hearing loss. As reported previously, most of the patients (90.6%) showed a "typical" phenotype; prelingual and severe-to-profound hearing loss. Forty-seven patients (73.4%) underwent cochlear implantation surgery and showed successful outcomes; approximately 85-90% of the patients showed a hearing level of 20-39 dB with cochlear implant and a Categories of Auditory Performance (CAP) scale level 6 or better. Although truncating mutations and p.Arg1939Gln were clearly related to severe phenotype, almost half of the patients with one or more non-truncating mutations showed mild-to-moderate hearing loss. Notably, patients with p.His513Arg, p.Ile1573Thr and p.Glu1910Lys showed "true" auditory neuropathy-like clinical characteristics. In this study, we have clarified genotype-phenotype correlation and efficacy of cochlear implantation for OTOF-related hearing loss patients in the biggest cohort studied to date. We believe that the clinical characteristics and genotype-phenotype correlation found in this study will support preoperative counseling and appropriate intervention for OTOF-related hearing loss patients.

DOI： 10.1007/s00439-021-02351-7

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思春期から青年期の難聴者が持つ代償・補償スキルと知識に関する一考察

中川敦子, 片岡祐子, 田中里実, 細川夏実, 菅谷明子, 假谷伸

Audiology Japan 64 ( 5 ) 389 - 389 2021.9

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Language：Japanese Publisher：(一社)日本聴覚医学会

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Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss. Reviewed

Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

Acta medica Okayama 75 ( 4 ) 511 - 516 2021.8

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WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

DOI： 10.18926/AMO/62404

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Immediate changes in transcription factors and synaptic transmission in the cochlea following acoustic trauma: A gene transcriptome study. Reviewed International journal

Yukihide Maeda, Shin Kariya, Kensuke Uraguchi, Junko Takahara, Shohei Fujimoto, Akiko Sugaya, Kazunori Nishizaki

Neuroscience research 165 6 - 13 2021.4

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Pathologic mechanisms in cochleae immediately following the onset of noise-induced hearing loss (NIHL) remain unclear. In this study, mice were exposed to 120 dB of octave band noise for 2 h to induce NIHL. Three hours after noise exposure, expression levels of the whole mouse genome in cochleae were analyzed by RNA-seq and DNA microarray. Differentially expressed genes (DEGs) exhibiting >2-fold upregulation or downregulation in noise-exposed cochleae compared to controls without noise exposure were identified. RNA-seq and microarray analyses identified 273 DEGs regulated at 3 h post-noise (51 upregulated and 222 downregulated). Bioinformatic analysis revealed that these DEGs were associated with the functional gene pathway "neuroactive ligand-receptor interaction" and included 28 genes encoding receptors for neurotransmitters such as gamma-aminobutyric acid and glutamate. Other DEGs included 25 genes encoding transcription factors. Downregulation of 4 neurotransmitter receptors (Gabra3, Gabra5, Gabrb1, Grm1) and upregulations of 5 transcription factors (Atf3, Dbp, Helt, Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting cells and hair cells in the organ of Corti at 12-h post-noise. The present data serve as a basis for further studies aimed at developing medical treatments for acute sensorineural hearing loss.

DOI： 10.1016/j.neures.2020.05.001

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Fertility Preservation Therapy Provided for Childhood, Adolescent, and Young Adult Cancer Patients —Current Status and Efforts to Improvement—,小児，思春期・若年がん患者に対する妊孕性温存療法―現状と改善の取り組み―

Akisada, N., Makino, T., Sugaya, A., Kataoka, Y., Ando, M., Monden, N., Nakatsuka, M.

Practica Oto-Rhino-Laryngologica 114 ( 12 ) 2021

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DOI： 10.5631/jibirin.114.957

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Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. Reviewed International journal

Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 138 110298 - 110298 2020.11

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OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

DOI： 10.1016/j.ijporl.2020.110298

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Progression of hearing loss and choice of hearing aids by patients in their 60s, 70s, and 80s and older: experience in the Japanese super-aged era. Reviewed

Maeda Y, Kariya S, Fujimoto S, Sugaya A, Kataoka Y, Nakagawa A, Tanaka S, Hosokawa N, Nishizaki K.

Acta Otolaryngol 139 1077 - 1082 2019.9

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Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. Reviewed

Sugaya A, Fukushima K, Takao S, Kasai N, Maeda Y, Fujiyoshi A, Kataoka Y, Kariya S, Nishizaki K.

Int J Pediatr Otorhinolaryngol 126 109619 - 109619 2019.8

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Targeted PCR Array Analysis of Genes in Innate Immunity and Glucocorticoid Signaling Pathways in Mice Cochleae Following Acoustic Trauma. Reviewed International journal

Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Yohei Noda, Akiko Sugaya, Shohei Fujimoto, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 39 ( 7 ) e593 - e600 2018

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AIM: To comprehensively analyze cochlear gene expressions related to innate immunity and glucocorticoid signaling at onset of acute noise-induced hearing loss (NIHL). BACKGROUND: Recent studies suggested innate immunity is involved in the cochlear pathology of NIHL. Glucocorticoids may modulate immune actions in cochleae. METHODS: Mice were exposed to 120 dB-octave band noise for 2 hours. Twelve hours later, a targeted PCR array analyzed cochlear expressions of 84 key genes in inflammation and immune pathways and 84 genes in the glucocorticoid signaling pathway. Real-time RT-PCR was used to analyze expression of two immune-related genes, Ccl12 and Glycam1, in noise-exposed cochleae with or without dexamethasone. RESULT: In inflammatory and immune gene pathways, 31.0% (26/84 genes) were significantly upregulated (>2-fold change) or downregulated (<0.5-fold change) (p < 0.05) in noise-exposed cochleae compared with controls. Sixteen of these differentially expressed genes (DEGs) encoded chemokines. DEGs included Ccl12, Ccl2, Ccl4, Ccl7, Cxcl1, Cxcl10, and Ptgs2 (upregulated genes), and Ccr7, Cxcr2, Kng1, Ltb, and Tnfsf14 (downregulated genes). In the glucocorticoid signaling pathway, 92.9% (78/84 genes) were unchanged in noise-exposed cochleae without dexamethasone administration. Cochlear expressions of Ccl12 and Glycam1 were significantly upregulated by noise and downregulated by dexamethasone. CONCLUSION: The targeted PCR array demonstrated that several dozen genes involved in innate immunity are actively regulated in cochleae with NIHL. The glucocorticoid signaling pathway was not endogenously regulated at 12 hours post-noise trauma. Systemic dexamethasone downregulated Ccl12 and Glycam1, which are upregulated in noise-exposed cochleae. These data may provide a basis for genomic medicine treatment of acute sensorineural hearing loss.

DOI： 10.1097/MAO.0000000000001874

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WFS1 mutation screening in a large series of Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis. Reviewed International journal

Masafumi Kobayashi, Maiko Miyagawa, Shin-Ya Nishio, Hideaki Moteki, Taro Fujikawa, Kenji Ohyama, Hirofumi Sakaguchi, Ikuyo Miyanohara, Akiko Sugaya, Yasushi Naito, Shin-Ya Morita, Yukihiko Kanda, Masahiro Takahashi, Kotaro Ishikawa, Yuki Nagano, Tetsuya Tono, Chie Oshikawa, Chiharu Kihara, Haruo Takahashi, Yoshihiro Noguchi, Shin-Ichi Usami

PloS one 13 ( 3 ) e0193359 2018

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A heterozygous mutation in the Wolfram syndrome type 1 gene (WFS1) causes autosomal dominant nonsyndromic hereditary hearing loss, DFNA6/14/38, or Wolfram-like syndrome. To date, more than 40 different mutations have been reported to be responsible for DFNA6/14/38. In the present study, WFS1 variants were screened in a large series of Japanese hearing loss (HL) patients to clarify the prevalence and clinical characteristics of DFNA6/14/38 and Wolfram-like syndrome. Massively parallel DNA sequencing of 68 target genes was performed in 2,549 unrelated Japanese HL patients to identify genomic variations responsible for HL. The detailed clinical features in patients with WFS1 variants were collected from medical charts and analyzed. We successfully identified 13 WFS1 variants in 19 probands: eight of the 13 variants were previously reported mutations, including three mutations (p.A684V, p.K836N, and p.E864K) known to cause Wolfram-like syndrome, and five were novel mutations. Variants were detected in 15 probands (2.5%) in 602 families with presumably autosomal dominant or mitochondrial HL, and in four probands (0.7%) in 559 sporadic cases; however, no variants were detected in the other 1,388 probands with autosomal recessive or unknown family history. Among the 30 individuals possessing variants, marked variations were observed in the onset of HL as well as in the presence of progressive HL and tinnitus. Vestibular symptoms, which had been rarely reported, were present in 7 out of 30 (23%) of the affected individuals. The most prevalent audiometric configuration was low-frequency type; however, some individuals had high-frequency HL. Haplotype analysis in three mutations (p.A716T, p.K836T, and p.E864K) suggested that the mutations occurred at these mutation hot spots. The present study provided new insights into the audiovestibular phenotypes in patients with WFS1 mutations.

DOI： 10.1371/journal.pone.0193359

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Relationship between pure-tone audiogram findings and speech perception among older Japanese persons. Reviewed International journal

Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

Acta oto-laryngologica 138 ( 2 ) 140 - 144 2018

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OBJECTIVE: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. METHODS: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson's correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. RESULTS: SP correlated well (r = -0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = -0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). CONCLUSION: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

DOI： 10.1080/00016489.2017.1378435

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次世代シークエンサー(NGS)を併用した難聴遺伝子検査が有用であった3症例

菅谷明子, 片岡祐子, 前田幸英, 假谷伸, 大道亮太郎, 峠和美, 佐藤吏江, 西崎和則

日本遺伝カウンセリング学会誌 38 ( 2 ) 120 - 120 2017.5

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中耳炎により外科的処置を要した小児人工内耳装用例の検討

片岡祐子, 假谷伸, 菅谷明子, 大道亮太郎, 福島邦博, 西崎和則

小児耳鼻咽喉科 38 ( 2 ) 153 - 153 2017.5

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新生児聴覚スクリーニング実施における費用対効果の検討

片岡祐子, 菅谷明子, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 4 ) 588 - 588 2017.4

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Cochlear Transcriptome Following Acoustic Trauma and Dexamethasone Administration Identified by a Combination of RNA-seq and DNA Microarray. Reviewed International journal

Yukihide Maeda, Ryotaro Omichi, Akiko Sugaya, Shin Kariya, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 38 ( 7 ) 1032 - 1042 2017

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AIM: To elucidate molecular mechanisms of noise-induced hearing loss (NIHL) and glucocorticoid therapy in the cochlea. BACKGROUND: Glucocorticoids are used to treat many forms of acute sensorineural hearing loss, but their molecular action in the cochlea remains poorly understood. METHODS: Dexamethasone was administered intraperitoneally immediately following acoustic overstimulation at 120 dB SPL for 2 hours to mice. The whole cochlear transcriptome was analyzed 12 and 24 hours following noise trauma and dexamethasone administration by both next-generation sequencing (RNA-seq) and DNA microarray. Differentially expressed genes (DEGs) with more than 2-fold changes after noise trauma and dexamethasone administration were identified. The functions of these DEGs were analyzed by David Bioinformatics Resources and a literature search. RESULTS: Twelve hours after acoustic overstimulation, immune-related gene pathways such as "chemokine signaling activity," "cytokine-cytokine receptor interaction," and "cell adhesion molecules (CAMs) in the immune system" were significantly changed compared with the baseline level without noise. These DEGs were involved in immune and defense responses in the cochlea. Dexamethasone was administered to this NIHL model, and it modulated gene pathways of "cytokine-cytokine receptor interaction" and "cell adhesion molecules (CAMs) in the immune system" at 12 hours, compared with saline-injected control. Dexamethasone-dependent DEGs were also involved in immune and defense responses. A literature search showed that 10 other genes associated with hearing functions were regulated by dexamethasone both at 12 and 24 hours post-administration. CONCLUSION: Dexamethasone modulates the immune reaction in the traumatized cochlea following acoustic overstimulation. Dexamethasone may also regulate cochlear functions other than immunity.

DOI： 10.1097/MAO.0000000000001373

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Genetic counseling of a hearing-impaired patient with multiple genetic mutations Reviewed

Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Kunihiro Fukushima, Kazunori Nishizaki

Journal of Otolaryngology of Japan 120 ( 2 ) 131 - 136 2017

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Oto-Rhino-Laryngological Society of Japan Inc.

DOI： 10.3950/jibiinkoka.120.131

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Reversal of the inner magnet of a cochlear implant after magnet resonance imaging Reviewed

Yuko Kataoka, Tomoyuki Naito, Shin Kariya, Akiko Sugaya, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

Journal of Otolaryngology of Japan 120 ( 5 ) 727 - 732 2017

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Oto-Rhino-Laryngological Society of Japan Inc.

DOI： 10.3950/jibiinkoka.120.727

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Pediatric central auditory processing disorder showing elevated threshold on pure tone audiogram Reviewed

Yukihide Maeda, Atsuko Nakagawa, Rie Nagayasu, Akiko Sugaya, Ryotaro Omichi, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

AURIS NASUS LARYNX 43 ( 5 ) 570 - 574 2016.10

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DOI： 10.1016/j.anl.2016.02.005

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Subjective hearing-related quality-of-life is a major factor in the decision to continue using hearing aids among older persons Reviewed

Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

ACTA OTO-LARYNGOLOGICA 136 ( 9 ) 919 - 922 2016.9

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DOI： 10.1080/00016489.2016.1183817

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MRI検査後に人工内耳インプラントのマグネットの反転を来たした2例

内藤智之, 片岡祐子, 假谷伸, 菅谷明子, 大道亮太郎, 前田幸英, 西崎和則

Otology Japan 26 ( 4 ) 570 - 570 2016.9

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急性感音難聴モデルマウスへのステロイド投与後の内耳遺伝子発現 RNA-seqとDNAマイクロアレイを用いた解析

前田幸英, 大道亮太郎, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

Otology Japan 26 ( 4 ) 489 - 489 2016.9

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人工内耳装用児の英語学習における実態調査

菅谷明子, 福島邦博, 谷伸, 長安吏江, 藤吉昭江, 片岡祐子, 前田幸英, 西崎和則

Otology Japan 26 ( 4 ) 405 - 405 2016.9

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乳幼児鼓膜インピーダンス測定における1000Hz tympanometryの有用性の検討

片岡祐子, 菅谷明子, 假谷伸, 大道亮太郎, 前田幸英, 福島邦博, 西崎和則

Otology Japan 26 ( 4 ) 449 - 449 2016.9

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頸部リンパ管腫に合併した滲出性中耳炎の1例

大道亮太郎, 菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊146 ) 99 - 99 2016.6

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岡山県における小児難聴例の診断時期の検討

片岡祐子, 鳥越暁子, 菅谷明子, 大道亮太郎, 前田幸英, 福島邦博

小児耳鼻咽喉科 37 ( 2 ) 129 - 129 2016.5

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人工内耳装用前の早期補聴が言語発達に与える効果の検証

菅谷明子, 福島邦博, 笠井紀夫, 藤吉昭江, 長安吏江, 片岡祐子, 前田幸英, 西崎和則

小児耳鼻咽喉科 37 ( 2 ) 126 - 126 2016.5

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初回手術後に長期間経過して対側人工内耳埋込術を施行された高度感音難聴児6例の検討

菅谷明子, 福島邦博, 假谷伸, 長安吏江, 片岡祐子, 前田幸英, 大道亮太郎, 西崎和則

日本耳鼻咽喉科学会会報 119 ( 4 ) 619 - 619 2016.4

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純音聴力閾値上昇を呈した聴覚情報処理障害の小児例

前田幸英, 菅谷明子, 片岡祐子, 大道亮太郎, 假谷伸, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 119 ( 4 ) 618 - 618 2016.4

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Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy Reviewed

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Rie Nagayasu, Atsuko Nakagawa, Toru Yamashita, Koji Abe, Kazunori Nishizaki

ACTA OTO-LARYNGOLOGICA 136 ( 3 ) 266 - 270 2016

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DOI： 10.3109/00016489.2015.1104722

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Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants Reviewed

Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Yuko Kataoka, Yukihide Maeda, Rie Nagayasu, Naomi Toida, Shyuhei Ohmori, Akie Fujiyoshi, Tomoko Taguchi, Ryotaro Omichi, Kazunori Nishizaki

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 79 ( 12 ) 2142 - 2146 2015.12

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DOI： 10.1016/j.ijporl.2015.09.036

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Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy Reviewed

Yukihide Maeda, Yuko Kataoka, Akiko Sugaya, Shin Kariya, Katsuhiro Kobayashi, Kazunori Nishizaki

AURIS NASUS LARYNX 42 ( 3 ) 249 - 253 2015.6

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DOI： 10.1016/j.anl.2014.11.002

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Novel ABHD12 Mutations in PHARC Patients: The Differential Diagnosis of Deaf-Blindness Reviewed

Hidekane Yoshimura, Takao Hashimoto, Toshinori Murata, Kunihiro Fukushima, Akiko Sugaya, Shin-ya Nishio, Shin-ichi Usami

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 124 ( 1 ) 77S - 83S 2015.5

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DOI： 10.1177/0003489415574513

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岡山県内胃瘻造設術施行施設へのアンケートからみる嚥下機能評価における耳鼻咽喉科医の役割

西崎和則, 春名威範, 牧野琢丸, 三木健太郎, 野田洋平, 檜垣貴哉, 菅谷明子, 小野田友男

日本耳鼻咽喉科学会会報 118 ( 4 ) 501 - 501 2015.4

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Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan Reviewed

Shuhei Ohmori, Akiko Sugaya, Naomi Toida, Etsuji Suzuki, Masato Izutsu, Tomoko Tsutsui, Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 79 ( 2 ) 196 - 201 2015.2

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DOI： 10.1016/j.ijporl.2014.12.006

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Outcomes of consonant-vowel monosyllable perception and word recognition after cochlear implantation in elderly Japanese patients Reviewed

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

ACTA OTO-LARYNGOLOGICA 135 ( 11 ) 1108 - 1112 2015

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DOI： 10.3109/00016489.2015.1062547

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2年以上聴力経過を観察した小児心因性難聴の7例

前田幸英, 片岡祐子, 菅谷明子, 長安吏江, 中川敦子, 假谷伸, 西﨑和則

AUDIOLOGY JAPAN 58 ( 5 ) 335 - 336 2015

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DOI： 10.4295/audiology.58.335

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Other Link： http://search.jamas.or.jp/link/ui/2016019205
当科で経験したBOR症候群の2家族例

浦口健介, 菅谷明子, 片岡祐子, 前田幸英, 假谷伸, 福島邦博, 西崎和則

Otology Japan 24 ( 4 ) 548 - 548 2014.9

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Assessment of hearing aid outcome using CADL Reviewed

Rie Nagayasu, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Kunihiro Fukushima, Kazunori Nishizaki

Journal of Otolaryngology of Japan 117 ( 8 ) 1126 - 1131 2014.8

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DOI： 10.3950/jibiinkoka.117.1126

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Effectiveness of Domain-Based Intervention for Language Development in Japanese Hearing-Impaired Children: A Multicenter Study Reviewed

Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Toshiyuki Ojima, Goro Takahashi, Takashi Nakagawa, Seiko Murai, Yasoichi Nakajima, Kazunori Nishizaki

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 123 ( 7 ) 500 - 508 2014.7

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DOI： 10.1177/0003489414525023

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[The age at which the grade of Special Child Dependent's Allowance Act can be judged in the case of deaf children]. Reviewed

Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 117 ( 9 ) 1200 - 4 2014

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The spread of neonatal hearing screening has made the identification of hearing loss in early childhood possible, and most of the children with hearing loss are diagnosed and provided with early intervention within several months after their birth. However, they have to wait to receive the Special Child Dependent's Allowance until their hearing levels are evaluated with audiometers. Under the Special Child Dependent's Allowance Act now in force, a delay of several years occurs for those children before they can receive the allowance after diagnosis. We retrospectively reviewed hearing test results of children who had not reacted at 90dBnHL bilaterally in ABR within 12 months after birth, and examined when those results were certain enough to determine their allowance eligibility. We found that the eligibility in children with hearing loss alone could be determined at 1 year of age; as for children who had other disorders, since it was mostly difficult to test them with an audiometer, the diagnosis of hearing loss must always be made carefully but it was also possible to determine the eligibility for the allowance at 1 year of age.

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Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery Reviewed

Yuko Kataoka, Tetsuo Ikezono, Kunihiro Fukushima, Koji Yuen, Yukihide Maeda, Akiko Sugaya, Kazunori Nishizaki

AURIS NASUS LARYNX 40 ( 4 ) 422 - 424 2013.8

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DOI： 10.1016/j.anl.2012.08.001

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Language Ability in the Intermediate-Scoring Group of Hearing-Impaired Children Reviewed

Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Akie Fujiyoshi, Tomoko Taguchi, Kana Omori, Toshiyuki Ojima, Kazunori Nishizaki

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 121 ( 4 ) 21 - 27 2012.4

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Effects of Early Identification and Intervention on Language Development in Japanese Children With Prelingual Severe to Profound Hearing Impairment Reviewed

Norio Kasai, Kunihiro Fukushima, Kana Omori, Akiko Sugaya, Toshiyuki Ojima

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 121 ( 4 ) 16 - 20 2012.4

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Assessment Package for Language Development in Japanese Hearing-Impaired Children (ALADJIN) as a Test Battery for the Development of Practical Communication Reviewed

Kunihiro Fukushima, Norio Kasai, Kana Omori, Akiko Sugaya, Akie Fujiyoshi, Tomoko Taguchi, Takayuki Konishi, Syuuhei Sugishita, Wataru Takei, Hiroshi Fujino, Toshiyuki Ojima, Kazunori Nishizaki

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 121 ( 4 ) 3 - 15 2012.4

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Syntactic Development in Japanese Hearing-Impaired Children Reviewed

Akie Fujiyoshi, Kunihiro Fukushima, Tomoko Taguchi, Kana Omori, Norio Kasai, Shinya Nishio, Akiko Sugaya, Rie Nagayasu, Takayuki Konishi, Syuuhei Sugishita, Jyunpei Fujita, Kazunori Nishizaki, Masae Shiroma

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 121 ( 4 ) 28 - 34 2012.4

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Cochlear implant at 11 months old for deafness after meningitis Reviewed

HAMADA Koji, SUGAYA Akiko, KATAOKA Yuko, MAEDA Yukihide, FUKUSHIMA Kunihiro, NISHIZAKI Kazunori

Ped ORL J 33 ( 1 ) 23 - 28 2012.3

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Language：Japanese Publisher：Japan Society for Pediatric Otorhinolaryngology

A case of rapidly progressive ossification of the cochlea after bacterial meningitis is reported. An eleven-month-old boy was referred to our hospital due to his loss of response to sound after suffering from meningitis at 8 months old. He did not respond to sound either by BOA or ABR at 105dB nHL. 3D reconstruction imaging with MRI suggested that the cochlea was completely occluded in his right inner ear. Possible progression to his left inner ear was suspected, and cochlear implant in his left ear was performed immediately. Ossification of the cochlea is frequently observed after meningitis. In cases with early and rapidly progressive ossification of the cochlea, repeated audiological evaluation and MRI imaging is indispensable in the follow-up after bacterial meningitis with very young infants.

DOI： 10.11374/shonijibi.33.23

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Five cases requiring revision or middle ear surgery after cochlear implantation Reviewed

SUGAYA Akiko, FUKUSHIMA Kunihiro, KATAOKA Yuko, MAEDA Yukihide, KASAI Norio, HIRAI Misato, NAGAYASU Rie, NISHIZAKI Kazunori

Ped ORL J 32 ( 3 ) 409 - 414 2011.12

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Revision/additional surgeries after cochlear implants are sometimes required because of device failure, hematoma, infections, and malinsertion/extrusion of electrodes. Younger implant age may also increase the incidence of additional ear surgery due to the immaturity of the Eustachean tubes. Since 1992, we have conducted 150 pediatric cochlear implants with three revisions (2.0%) or two additional surgeries (1.3%) required so far. All three revision cases were due to device failure, and ipsilateral explantation/reimplantation surgeries were conducted. The two additional cases included a case of ventilation tube malplacement and a case of myringoplasty. A case with implant failure after head trauma is reported here in detail.<br/> A 7-year-old girl who received cochlear implantation at the age of two visited our hospital because she didn't respond to sound after a head trauma. Her speech perception had been good until her head was struck by a swing in a park, and she came to our hospital four days later. An impedance check or NRT of the cochlear implant was impossible, and explantation and reimplantation of the same side cochlear implant was performed six weeks later. Insertion of the electrodes was extremely difficult because of inner ear malformation, but the right position of the electrode was finally confirmed by X-ray. Her speech perception and language development were good after the operation.

DOI： 10.11374/shonijibi.32.409

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Expression analysis of microRNAs in murine cochlear explants Reviewed

Misato Hirai, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Yuko Kataoka, Kazunori Nishizaki

NEUROREPORT 22 ( 13 ) 652 - 654 2011.9

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DOI： 10.1097/WNR.0b013e32834a0273

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Orbital Emphysema Causing Syncope Reviewed

Kentaroh Miki, Yorihisa Orita, Fumiaki Kumase, Akiko Sugaya, Misato Hirai, Yasuyuki Noyama, Kiyoko Nakai, Akiko Narita, Jiroh Seguchi

ACTA MEDICA OKAYAMA 65 ( 1 ) 55 - 57 2011.2

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Subsidizing hearing aid purchase in mild to moderate pediatric hearing - Pediatric status following prefectural assembly subvention Reviewed

Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Yu Masuda, Kazunori Nishizaki

Journal of Otolaryngology of Japan 114 ( 8 ) 731 - 736 2011

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DOI： 10.3950/jibiinkoka.114.731

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Progressive or delayed early-onset pediatric sensorineural hearing loss Reviewed

Yuko Kataoka, Kunihiro Fukushima, Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Yu Masuda, Kazunori Nishizaki

Journal of Otolaryngology of Japan 114 ( 6 ) 557 - 561 2011

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DOI： 10.3950/jibiinkoka.114.557

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A case of oncocytoma of the deep lobe of the parotid gland

MIKI Kentaro, ORITA Yorihisa, SUGAYA Akiko, HIRAI Misato, NAKAI Kiyoko, NOSE Soichiro

Stomato-pharyngology 23 ( 2 ) 237 - 241 2010.6

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Language：Japanese Publisher：Japan Society of Stomato-pharyngology

We report a case of oncocytoma of the deep parotid gland lobe. A 64-year-old man admitted for an infra auricular mass was confirmed to have a firm mass deep in the left parotid gland lobe, suggesting Warthin's tumor. The resected tumor was histologically diagnosed as oncocytoma of the parotid gland. Despite its relative rarity, this tumor should be completly resected with sufficient margin, as with other benign parotid gland tumors.

DOI： 10.14821/stomatopharyngology.23.237

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Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland Reviewed

Yorihisa Orita, Kazuo Hamaya, Kentaroh Miki, Akiko Sugaya, Misato Hirai, Kiyoko Nakai, Sohichiroh Nose, Tadashi Yoshino

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 267 ( 5 ) 801 - 806 2010.5

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DOI： 10.1007/s00405-009-1149-7

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Large cerebellar arteriovenous malformation with dizziness Reviewed

Misato Hirai, Yorihisa Orita, Akiko Sugaya, Kazunori Seno, Koji Yuen

Practica Oto-Rhino-Laryngologica 101 ( 10 ) 759 - 764 2008

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DOI： 10.5631/jibirin.101.759

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耳鼻咽喉科日常検査リファレンスブック

中川尚志（乳幼児聴力検査）

中山書店 2024.5 （ ISBN:9784521749532 ）

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Total pages：xv, 497p Language：Japanese

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こどもの難聴診療マニュアル

福島, 邦博, 神田, 幸彦（新生児聴覚スクリーニングの実際環境調整指導のポイント）

日本医事新報社 2024.3 （ ISBN:9784784924776 ）

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Total pages：262p Language：Japanese

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人工内耳が感染を起こした場合、どの様に対処しますか？

東京医学社 2016

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普通学校（メインストリーム）における教育

菅谷明子（ Role： Joint author）

診断と治療社 2014

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中耳炎様所見で発症し内耳窓閉鎖術を施行した外リンパ瘻2例の検討

菅谷明子, 假谷伸, 大道亮太郎, 片岡祐子, 前田幸英, 安藤瑞生

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 4 ) 600 - 600 2024.4

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Photon Counting CTが診断に有用であった外傷性耳小骨離断の1例

高橋優花, 檜垣文代, 北山貴裕, 浅野雄大, 大川七子, 槇本怜子, 児島克英, 菅谷明子, 平木隆夫

Japanese Journal of Radiology 42 ( Suppl. ) 45 - 45 2024.2

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Language：Japanese Publisher：(公社)日本医学放射線学会

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難聴児へのシームレスな多職種連携支援聴覚障害者への就労支援・就労継続支援と聴覚障害児の就労前支援について Reviewed

菅谷明子

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 1 ) 10 - 15 2024.1

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DOI： 10.3950/jibiinkotokeibu.127.1_10

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今から始めるこどもから大人への移行支援難聴児のスキル獲得のための多職種連携支援について考える

菅谷明子

小児耳鼻咽喉科 44 ( 2 ) 131 - 131 2023.10

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Beckwith-Wiedemann Syndromeに対する舌縮小術後に構音訓練を要した2症例

中川敦子, 妹尾貴矢, 菅谷明子

言語聴覚研究 20 ( 3 ) 267 - 267 2023.9

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人工内耳装用児におけるデジタルワイヤレス補聴援助システムの心理的効果

藤原真由美, 問田直美, 矢永美穂, 平岡東佳, 片岡祐子, 菅谷明子, 福田章一郎

Audiology Japan 66 ( 5 ) 377 - 377 2023.9

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特異的言語発達障害が併存した中等度難聴児(DLI)の1例 Reviewed

藤吉昭江, 宇野彰, 菅谷明子, 福島邦博

音声言語医学 64 ( 3 ) 182 - 189 2023.7

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00189&link_issn=&doc_id=20230801440006&doc_link_id=10.5112%2Fjjlp.64.182&url=https%3A%2F%2Fdoi.org%2F10.5112%2Fjjlp.64.182&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif
アブミ骨手術に際しワイヤーピストンの固定に工夫を要した外耳・中耳形態異常症例

藤田尚晃, 假谷伸, 濱本真一, 橘智靖, 松本淳也, 黒田一範, 假谷彰文, 菅谷明子, 大道亮太郎, 原浩貴

耳鼻咽喉科臨床補冊 ( 補冊161 ) 70 - 70 2023.6

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1歳以上7歳未満で発見された難聴児に関する日耳鼻乳幼児委員会全国調査結果

益田慎, 麻生伸, 守本倫子, 樫尾明憲, 神田幸彦, 菅谷明子, 中澤操, 増田佐和子, 小川郁, 中川尚志

日本耳鼻咽喉科頭頸部外科学会会報 126 ( 4 ) 672 - 672 2023.4

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高齢の一般住民を対象とした難聴に関する実地調査報告

假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 大道亮太郎, 浜本真一, 安藤瑞生, 原浩貴

日本耳鼻咽喉科頭頸部外科学会会報 126 ( 4 ) 551 - 551 2023.4

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高齢の一般住民を対象とした難聴に関する実地調査報告

假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 大道亮太郎, 浜本真一, 安藤瑞生, 原浩貴

日本耳鼻咽喉科頭頸部外科学会会報 126 ( 4 ) 551 - 551 2023.4

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難聴児へのシームレスな多職種連携支援聴覚障害者の就労支援・就労継続支援および聴覚障害児の就労前支援について

菅谷明子

日本耳鼻咽喉科頭頸部外科学会会報 126 ( 4 ) 415 - 415 2023.4

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人工内耳装用児の術後コミュニケーション状態における術前CTによる前庭水管拡大症の影響の検討

菅谷明子, 假谷伸, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生

日本耳科学会総会・学術講演会抄録集 32回 342 - 342 2022.10

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Cogan症候群に対して人工内耳植込術を施行した一例

佐藤明日香, 安藤瑞生, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 大道亮太郎

日本耳科学会総会・学術講演会抄録集 32回 271 - 271 2022.10

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当院における聴覚情報処理検査(APT)結果のデータ分析

細川夏実, 中川敦子, 田中里実, 片岡祐子, 前田幸英, 菅谷明子, 假谷伸

Audiology Japan 65 ( 5 ) 323 - 323 2022.9

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当院における聴覚情報処理検査(APT)結果のデータ分析

細川夏実, 中川敦子, 田中里実, 片岡祐子, 前田幸英, 菅谷明子, 假谷伸

Audiology Japan 65 ( 5 ) 323 - 323 2022.9

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小児難聴と人工聴覚器

假谷伸, 菅谷明子, 片岡祐子

耳鼻咽喉科 2 ( 2 ) 263 - 269 2022.8

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脳表ヘモジデリン沈着症による重度感音難聴に対して人工内耳再挿入を行った1例

大道亮太郎, 假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 安藤瑞生

耳鼻咽喉科臨床補冊 ( 補冊159 ) 88 - 88 2022.6

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当科を受診したANCA関連血管炎性中耳炎の12例(24耳)の検討

藤澤郁, 片岡祐子, 清水藍子, 大道亮太郎, 菅谷明子, 前田幸英, 假谷伸, 安藤瑞生

耳鼻咽喉科臨床補冊 ( 補冊159 ) 73 - 73 2022.6

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音韻障害を有する人工内耳装用児の言語発達経過

菅谷明子, 福島邦博, 藤吉昭江, 假谷伸, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生

日本耳鼻咽喉科頭頸部外科学会会報 125 ( 4 ) 767 - 767 2022.4

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感音難聴患者における聴力と体平衡の関係の統計的検討

前田幸英, 藤澤郁, 菅谷明子, 片岡祐子, 假谷伸, 安藤瑞生

日本耳鼻咽喉科頭頸部外科学会会報 125 ( 4 ) 744 - 744 2022.4

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小児、思春期・若年がん患者に対する妊孕性温存療法現状と改善の取り組み

秋定直樹, 牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2021.12

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創部感染の制御が可能であった人工内耳植え込み術後の小児の1例

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸, 安藤瑞生

日本耳鼻咽喉科免疫アレルギー感染症学会誌 1 ( 3 ) 177 - 180 2021.12

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脳腫瘍治療後の進行性難聴

片岡祐子, 前田幸英, 菅谷明子, 大道亮太郎, 假谷伸

日本耳科学会総会・学術講演会抄録集 31回 397 - 397 2021.10

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当科で人工内耳再植え込み術を施行した10例の検討

菅谷明子, 假谷伸, 福島邦博, 片岡祐子, 大道亮太郎, 前田幸英, 安藤瑞生

日本耳科学会総会・学術講演会抄録集 31回 217 - 217 2021.10

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心因反応による装用困難が疑われた人工内耳埋め込み術後の小児の2症例

假谷伸, 片岡祐子, 前田幸英, 大道亮太郎, 菅谷明子, 安藤瑞生

日本耳科学会総会・学術講演会抄録集 31回 401 - 401 2021.10

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思春期から青年期の難聴者が持つ代償・補償スキルと知識に関する一考察

中川敦子, 片岡祐子, 田中里実, 細川夏実, 菅谷明子, 假谷伸

Audiology Japan 64 ( 5 ) 389 - 389 2021.9

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デジタルワイヤレス補聴援助システムが軽度・中等度難聴児の心理に及ぼす影響についての検討

藤原真由美, 問田直美, 矢永美穂, 平岡東佳, 申川美晴, 菅谷明子, 福田章一郎

Audiology Japan 64 ( 5 ) 359 - 359 2021.9

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聴覚障害をもつ小・中・高校生に対する学校指導パンフレットの作成

片岡祐子, 中川敦子, 菅谷明子, 假谷伸, 安藤瑞生

小児耳鼻咽喉科 42 ( 2 ) 187 - 187 2021.6

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人工内耳装用児にみられた極端な言語発達遅滞(disproportionate language impairment:DLI)に対して音韻指導を実施した2例の検討

藤吉昭江, 福島邦博, 伏見久未子, 北野朱里, 菅谷明子

耳鼻と臨床 67 ( 3 ) 136 - 142 2021.5

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高度難聴児における読み書き障害が言語発達に与える影響の検討

菅谷明子, 福島邦博, 笠井紀夫, 藤吉昭江, 片岡祐子, 前田幸英, 假谷伸, 安藤瑞生, 西崎和則

日本耳鼻咽喉科学会会報 124 ( 4 ) 645 - 645 2021.4

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非良聴耳への人工内耳埋込術の妥当性に関する統計学的検討

大道亮太郎, 前田幸英, 菅谷明子, 片岡祐子, 假谷伸, 福島邦博, 安藤瑞生, 西崎和則

日本耳鼻咽喉科学会会報 124 ( 4 ) 567 - 567 2021.4

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新型コロナウイルス感染症対策に伴う聴覚コミュニケーションへの影響

片岡祐子, 前田幸英, 大道亮太郎, 菅谷明子, 假谷伸, 安藤瑞生

日本耳鼻咽喉科学会会報 124 ( 4 ) 613 - 613 2021.4

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両側難聴児・者が学校生活で抱える問題に関する調査の検討

片岡祐子, 菅谷明子, 中川敦子, 田中里実, 問田直美, 福島邦博, 前田幸英, 假谷伸

Audiology Japan 64 ( 1 ) 87 - 95 2021.2

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前庭蝸牛症状で発症した卵巣癌の症例

清水藍子, 前田幸英, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊155 ) 157 - 157 2020.12

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術後創部感染の制御が可能であった人工内耳植え込み術後の小児の1例

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸

日本耳鼻咽喉科感染症・エアロゾル学会会誌 8 ( 4 ) 357 - 358 2020.12

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両側急性中耳炎から内耳炎に波及した成人症例

浦口健介, 菅谷明子, 前田幸英, 假谷伸

日本耳科学会総会・学術講演会抄録集 30回 252 - 252 2020.11

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ワールデンブルグ症候群小児7例の臨床像の検討

片岡祐子, 假谷伸, 菅谷明子, 西崎和則

小児耳鼻咽喉科 41 ( 2 ) 150 - 150 2020.11

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内耳形態異常を伴う小児人工内耳30例の検討

菅谷明子, 片岡祐子, 福島邦博, 佐藤吏江, 前田幸英, 田中里実, 假谷伸

日本耳科学会総会・学術講演会抄録集 30回 192 - 192 2020.11

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左右差のある両側難聴者におけるBiCROS補聴器装用経験

片岡祐子, 前田幸英, 菅谷明子, 田中里実, 中川敦子, 假谷伸

Audiology Japan 63 ( 5 ) 323 - 323 2020.9

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音響外傷マウス蝸牛における、自然免疫応答の転写制御について

前田幸英, 大道亮太郎, 菅谷明子, 假谷伸

Audiology Japan 63 ( 5 ) 343 - 343 2020.9

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当院の感音難聴患者の年齢別聴力像と、補聴器外来での補聴器選択率について

藤澤郁, 前田幸英, 藤本将平, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 123 ( 4 ) 1061 - 1061 2020.9

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人工内耳装用児のピッチおよびプロソディーに関する研究

菅谷明子, 假谷伸, 片岡祐子, 前田幸英, 中川敦子, 田中里実, 細川夏実, 西崎和則

日本耳鼻咽喉科学会会報 123 ( 4 ) 1084 - 1084 2020.9

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身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究インクルーシブ教育を受ける思春期の難聴者の抱える問題に関する研究

西崎和則, 片岡祐子, 菅谷明子

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究令和元年度総括・分担研究報告書(Web) 2020

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思春期の一側性難聴児の学校生活における問題の検討

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 西崎和則

日本耳科学会総会・学術講演会抄録集 29回 276 - 276 2019.10

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顕微鏡と内視鏡の併用下に摘出した錐体部真珠腫の一例

假谷伸, 片岡祐子, 菅谷明子, 西崎和則

日本耳科学会総会・学術講演会抄録集 29回 326 - 326 2019.10

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耳鼻咽喉科外来で聴覚情報処理検査をおこなった、加齢性難聴の3例症例提示

前田幸英, 藤本将平, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

Audiology Japan 62 ( 5 ) 464 - 464 2019.10

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3次元画像解析システムを利用した中耳手術における顔面神経と外側半規管の解剖学的解析

西崎和則, 假谷伸, 片岡祐子, 菅谷明子, 前田幸英

日本耳科学会総会・学術講演会抄録集 29回 236 - 236 2019.10

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超高齢社会の耳鼻咽喉科外来での、感音難聴患者の統計

前田幸英, 藤本将平, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

日本耳科学会総会・学術講演会抄録集 29回 273 - 273 2019.10

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思春期の難聴者が抱える問題に関するアンケート調査

片岡祐子, 菅谷明子, 中川敦子, 問田直美, 前田幸英, 假谷伸, 西崎和則

Audiology Japan 62 ( 5 ) 386 - 386 2019.10

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当院での軟骨伝導補聴器フィッティングの検討

田中里実, 中川敦子, 細川夏実, 菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 原大介, 西崎和則

Audiology Japan 62 ( 5 ) 394 - 394 2019.10

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異なる聴力像を示したGjB2遺伝子変異による難聴の双胎児例

菅谷明子, 片岡祐子, 假谷伸, 前田幸英, 田中里実, 中川敦子, 細川夏実, 問田直美, 大森修平, 西崎和則

Audiology Japan 62 ( 5 ) 426 - 426 2019.10

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診断・遺伝カウンセリングに際し他科との連携が重要であったRobin sequence例

片岡祐子, 菅谷明子, 假谷伸, 西崎和則

小児耳鼻咽喉科 40 ( 2 ) 172 - 172 2019.5

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カタカナ書字困難に対する介入を行った軽度難聴児の1例

菅谷明子, 福島邦博, 片岡祐子, 前田幸英, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 122 ( 4 ) 678 - 678 2019.4

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爆発事故が原因と考えられた急性内耳障害例

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 122 ( 4 ) 630 - 630 2019.4

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難治性聴覚障害に関する調査研究当科で経験したWFS1遺伝子変異による若年発症型両側性感音難聴の2家系例

西崎和則, 片岡祐子, 前田幸英, 菅谷明子

難治性聴覚障害に関する調査研究平成30年度総括・分担研究報告書(Web) 2019

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Clinical Evaluation of 1,000-Hz Tympanometry for the Diagnosis of Exudative Otitis Media in Japanese Infants

片岡祐子, 前田幸英, 藤澤郁, 菅谷明子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 122 ( 7 ) 2019

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身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究「遅発性難聴の早期発見」「思春期の難聴児が抱える問題の検証」に関する研究

西崎和則, 片岡祐子, 菅谷明子

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究平成30年度総括・分担研究報告書(Web) 2019

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経口的に切開排膿をし得た魚骨異物摘出後に生じた咽後膿瘍の1例

小山貴久, 假谷伸, 野田実里, 檜垣貴哉, 菅谷明子, 片岡祐子, 岡野光博, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 6 ( 3 ) 83 - 83 2018.9

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MRSA中耳炎罹患後に人工内耳埋込み術を施行した2例

菅谷明子, 假谷伸, 片岡祐子, 前田幸英, 小山貴久, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 6 ( 3 ) 73 - 73 2018.9

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乳幼児期に発見された両側遅発性難聴例の検討

片岡祐子, 菅谷明子, 問田直美, 前田幸英, 假谷伸, 西崎和則

Audiology Japan 61 ( 5 ) 420 - 420 2018.9

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小児における人工内耳術後のマッピング開始時期の検討

菅谷明子, 假谷伸, 福島邦博, 片岡祐子, 前田幸英, 佐藤吏江, 西崎和則

Audiology Japan 61 ( 5 ) 402 - 402 2018.9

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特発性髄液耳漏の1例

藤本将平, 片岡祐子, 菅谷明子, 前田幸英, 仮谷伸, 西崎和則

Otology Japan 28 ( 4 ) 525 - 525 2018.9

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急性音響性難聴マウス蝸牛におけるケモカイン遺伝子群の発現

前田幸英, 假谷伸, 大道亮太郎, 菅谷明子, 西崎和則

Otology Japan 28 ( 4 ) 365 - 365 2018.9

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視覚情報優位を呈し就学機関の決定に難渋した中等度難聴の1例

片岡祐子, 菅谷明子, 假谷伸, 西崎和則

小児耳鼻咽喉科 39 ( 2 ) 112 - 112 2018.6

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新生児聴覚スクリーニングでパスした後に発見された難聴児の検討

片岡祐子, 菅谷明子, 茂原暁子, 福島邦博, 前田幸英, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 4 ) 596 - 596 2018.4

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日本人高齢難聴者における、純音聴力閾値と語音明瞭度との統計

前田幸英, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 4 ) 526 - 526 2018.4

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術後聴力の改善を認めたMalleus barの1症例

野田実里, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 4 ) 614 - 614 2018.4

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次世代シークエンサーを併用した難聴の遺伝学的検査が有用であった小児難聴の3例

菅谷明子, 菅谷明子, 片岡祐子, 片岡祐子, 峠和美, 假谷伸, 前田幸英, 大道亮太郎, 佐藤吏江, 西崎和則

日本遺伝カウンセリング学会誌 39 ( 3 ) 2018

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The Cost-Effectiveness of Newborn Hearing Screening

片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 10 ) 2018

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急性音響外傷マウスにおける炎症関連遺伝子の関与

前田幸英, 假谷伸, 大道亮太郎, 菅谷明子, 西崎和則

Otology Japan 27 ( 4 ) 540 - 540 2017.10

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蝸牛型耳硬化症にて人工内耳埋め込み術を施行した3例

内藤智之, 假谷伸, 片岡祐子, 浦口健介, 牧原靖一郎, 大道亮太郎, 菅谷明子, 前田幸英, 福島邦博, 西崎和則

Otology Japan 27 ( 4 ) 367 - 367 2017.10

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新生児聴覚スクリーニング開始後の学齢期の人工内耳装用児における言語発達

菅谷明子, 福島邦博, 佐藤吏江, 假谷伸, 前田幸英, 片岡祐子, 大道亮太郎, 西崎和則

Otology Japan 27 ( 4 ) 654 - 654 2017.10

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MRI検査後に人工内耳インプラント磁石の反転を来した2症例

片岡祐子, 内藤智之, 假谷伸, 菅谷明子, 前田幸英, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 5 ) 727 - 732 2017.5

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デキサメタゾン投与後の蝸牛遺伝子発現パターンの経時的・動態的検討

前田幸英, 大道亮太郎, 菅谷明子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 4 ) 589 - 589 2017.4

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複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリング経験

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 大道亮太郎, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 2 ) 2017

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【知っているようで知らない人工内耳Q&A】術後の問題点とトラブル人工内耳が感染を起こした場合、どのように対処しますか?

菅谷明子

JOHNS 32 ( 12 ) 1771 - 1773 2016.12

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Retrospective chart review among 50 consecutive cases of bilateral pediatric cochlear implants

長安吏江, 菅谷明子, 假谷伸, 福島邦博, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 西崎和則

小児耳鼻咽喉科 37 ( 1 ) 2016

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Middle Ear Infection Caused by Shewanella putrefaciens after Sea Bathing: A Case Report

藤本将平, 片岡祐子, 假谷伸, 菅谷明子, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 4 ( 1 ) 2016

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A Survey on the Participation of Children with Cochlear Implants in Sports

片岡祐子, 菅谷明子, 假谷伸, 大道亮太郎, 前田幸英, 福島邦博, 西崎和則

Otology Japan 26 ( 3 ) 2016

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人工内耳装用者のスポーツ時における問題に関するアンケート調査

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 大道亮太郎, 福島邦博, 西崎和則

Otology Japan 25 ( 4 ) 673 - 673 2015.9

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顔面神経麻痺、感音難聴を呈した髄膜癌腫症の2例

大道亮太郎, 前田幸英, 假谷伸, 片岡祐子, 菅谷明子, 西崎和則

Otology Japan 25 ( 4 ) 730 - 730 2015.9

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人工内耳装用者のピッチ弁別およびプロソディーによる感情理解に関する研究

菅谷明子, 福島邦博, 長安吏江, 假谷伸, 前田幸英, 片岡祐子, 大道亮太郎, 西崎和則

Otology Japan 25 ( 4 ) 671 - 671 2015.9

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成人期になり診断したAuditory Processing Disorderの1症例

中希久子, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 西崎和則

Otology Japan 25 ( 4 ) 459 - 459 2015.9

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蝸牛におけるステロイド作用機序 Charcot-Marie-Tooth neuropathy関連蛋白、Myelin protein zeroの制御

前田幸英, 假谷伸, 菅谷明子, 片岡祐子, 西崎和則

Otology Japan 25 ( 4 ) 618 - 618 2015.9

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脳表ヘモジデリン沈着症に伴う進行性高度感音難聴に対し人工内耳埋め込み術を行い良好な経過を得た1例

大道亮太郎, 假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊142 ) 106 - 106 2015.6

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複数の遺伝子変異を有する難聴者における遺伝カウンセリングの経験

片岡祐子, 菅谷明子, 長安吏江, 前田幸英, 福島邦博, 西崎和則

日本遺伝カウンセリング学会誌 36 ( 2 ) 78 - 78 2015.5

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人工内耳埋め込み術を施行したWaardenburg症候群の2例

大道亮太郎, 菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 福島邦博, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 224 - 224 2015.4

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福山型先天性筋ジストロフィー患児に対する人工内耳埋め込み術

假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 大道亮太郎, 西崎和則

日本耳鼻咽喉科学会会報 118 ( 4 ) 492 - 492 2015.4

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言語評価の後に補聴器装用・言語訓練の開始に至った中等度難聴の一例

中川敦子, 菅谷明子, 福島邦博, 前田幸英, 片岡祐子, 藤吉昭江, 長安吏江, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 232 - 232 2015.4

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当科における急性低音障害型感音難聴の治療と予後の検討

菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 118 ( 4 ) 604 - 604 2015.4

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当科における成人人工内耳症例の検討埋め込み時65歳以上の術後成績について

前田幸英, 菅谷明子, 長安吏江, 片岡祐子, 假谷伸, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 118 ( 4 ) 587 - 587 2015.4

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当科における小児の両側人工内耳症例50例の検討

菅谷明子, 假谷伸, 長安吏江, 片岡祐子, 前田幸英, 福島邦博, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 222 - 222 2015.4

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複数の難聴遺伝子変異を有したAuditory Neuropathy Spectrum Disorderの1例

内藤智之, 菅谷明子, 假谷伸, 長安史江, 片岡祐子, 前田幸英, 福島邦博, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 218 - 218 2015.4

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海水浴後に罹患したShewanella putrefaciensによる中耳感染症の1例

藤本将平, 片岡祐子, 馬場雄三, 假谷伸, 菅谷明子, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 2 ( 3 ) 21 - 21 2014.9

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成人期に診断したAuditory Processing Disordersの1例

藤本将平, 假谷伸, 片岡祐子, 前田幸英, 菅谷明子, 福島邦博, 西崎和則

Otology Japan 24 ( 4 ) 543 - 543 2014.9

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難聴児に対する特別児童扶養手当等級判定時期に関する検討乳児期にABR90dBnHL無反応であった児の聴力経過より

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 9 ) 1200 - 1204 2014.9

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実用コミュニケーション能力検査(CADL)簡易版を用いた補聴器装用効果の検討

長安吏江, 前田幸英, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 8 ) 1126 - 1131 2014.8

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【小児科医の疑問に答える-耳鼻咽喉科の知識】聴覚言語難聴児の人工内耳と補聴器言語発達との関係は?

菅谷明子

小児科診療 77 ( 7 ) 869 - 876 2014.7

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当科で経験したBOR症候群の家族例

菅谷明子, 福島邦博, 前田幸英, 片岡祐子, 西崎和則

日本遺伝カウンセリング学会誌 35 ( 2 ) 80 - 80 2014.5

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岡山大学耳鼻咽喉科における補聴器外来の現況高齢者の補聴に関連して

前田幸英, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 4 ) 535 - 535 2014.4

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岡山県における軽度・中等度難聴児補聴器助成事業実施状況の検討

片岡祐子, 福島邦博, 前田幸英, 菅谷明子, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 4 ) 494 - 494 2014.4

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【小児難聴Update】小児遺伝性難聴

菅谷明子, 福島邦博

耳鼻咽喉科・頭頸部外科 86 ( 2 ) 140 - 146 2014.2

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当科での盲聾症候群5症例の臨床、遺伝子診断

前田幸英, 福島邦博, 片岡祐子, 菅谷明子, 西崎和則

Otology Japan 23 ( 4 ) 604 - 604 2013.10

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岡山県において先天性風疹症候群により難聴をきたした症例の検討

浦口健介, 前田幸英, 片岡祐子, 菅谷明子, 福島邦博, 西崎和則

Otology Japan 23 ( 4 ) 766 - 766 2013.10

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【検査結果をどう読むか?】聴覚領域の検査乳幼児聴力検査

菅谷明子, 片岡祐子, 福島邦博

JOHNS 29 ( 9 ) 1497 - 1499 2013.9

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顔面神経麻痺、外耳道腫脹を契機に発見された急性リンパ性白血病再発症例

前田幸英, 假谷伸, 福島邦博, 片岡祐子, 菅谷明子, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊135 ) 74 - 74 2013.7

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視神経萎縮を伴った進行性感音難聴の1家系例

菅谷明子, 片岡祐子, 福島邦博, 前田幸英, 西崎和則

日本遺伝カウンセリング学会誌 34 ( 2 ) 64 - 64 2013.5

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進行性難聴家系の未発症児に対する遺伝カウンセリング経験

片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 西崎和則

日本遺伝カウンセリング学会誌 34 ( 2 ) 53 - 53 2013.5

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視神経萎縮を伴った進行性感音難聴の1家系例

福本晶, 菅谷明子, 片岡祐子, 福島邦博, 長安吏江, 西崎和則

日本耳鼻咽喉科学会会報 116 ( 4 ) 533 - 533 2013.4

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乳児期にABRにて90dB無反応であった児の聴力経過

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 116 ( 4 ) 475 - 475 2013.4

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補聴器装用効果のアウトカム指標

菅谷明子, 福島邦博

耳鼻咽喉科臨床 106 ( 4 ) 372 - 373 2013.4

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岡山県に導入された新生児聴覚スクリーニングの効果の検証

福島邦博, 菅谷明子, 片岡祐子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 116 ( 4 ) 474 - 474 2013.4

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言語習得期前高度難聴に続発した言語発達障害を有する就学児への体系的言語指導を用いた多施設共同介入試験

菅谷明子, 福島邦博, 笠井紀夫, 藤吉昭江, 高橋吾郎, 中川尚志, 西崎和則

日本耳鼻咽喉科学会会報 116 ( 4 ) 427 - 427 2013.4

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The difference between auditory method and auditory-visual method in hearing impaired children for the Japanese language development

NAKAZAWA Misao, SUGAYA Akiko, KASAI Norio, FUKUSHIMA Kunihiro

33 ( 3 ) 247 - 251 2012.12

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【難病への取り組み】小児難聴に対する取り組み岡山から全国への発信

片岡祐子, 福島邦博, 菅谷明子, 西崎和則

岡山医学会雑誌 124 ( 2 ) 155 - 159 2012.8

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難聴児における言語発達中間群の特徴について

菅谷明子, 福島邦博, 笠井紀夫, 藤吉昭江, 西崎和則

小児耳鼻咽喉科 33 ( 2 ) 150 - 150 2012.6

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発見が遅れた難聴児に対する人工内耳装用効果および言語指導について

藤吉昭江, 福島邦博, 長安吏江, 菅谷明子, 笠井紀夫, 西崎和則

小児耳鼻咽喉科 33 ( 2 ) 126 - 126 2012.6

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【急性感音難聴の最新治療戦略】急性感音難聴の治療戦略髄膜炎と急性感音難聴

菅谷明子, 福島邦博

JOHNS 28 ( 5 ) 795 - 798 2012.5

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Language development of prelingually deafened children with cochlear implant

SUGAYA Akiko, FUKUSHIMA Kunihiro, KASAI Norio, KATAOKA Yuko, MAEDA Yukihide, NAGAYASU Rie, TOIDA Naomi, OMORI Shuhei, NISHIZAKI Kazunori

55 ( 2 ) 126 - 131 2012.4

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CADL(実用コミュニケーション検査)による補聴器装用効果の検討

前田幸英, 菅谷明子, 福島邦博, 片岡祐子, 西崎和則

日本耳鼻咽喉科学会会報 115 ( 4 ) 494 - 494 2012.4

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「小学生の読み書きスクリーニング検査(STRAW)」で低値を示す聴覚障害児のプロフィール

福島邦博, 笠井紀夫, 菅谷明子, 西崎和則

日本耳鼻咽喉科学会会報 115 ( 4 ) 492 - 492 2012.4

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【小児の耳鼻咽喉科108の疑問】聴覚難聴の原因で多いのは?

菅谷明子, 福島邦博

JOHNS 28 ( 3 ) 288 - 290 2012.3

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聴覚スクリーニング検査の有用性と科学的根拠 (特集いわゆる"正常新生児"の理想のケアをめざして)

菅谷明子, 福島邦博

周産期医学 42 ( 2 ) 225 - 229 2012.2

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軽度および中等度難聴児における就学期における言語発達の検討

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

Otology Japan 21 ( 4 ) 738 - 738 2011.10

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難聴児の療育方針別の言語発達の違いについて

菅谷明子, 中澤操, 笠井紀夫, 福島邦博, 西崎和則

Otology Japan 21 ( 4 ) 742 - 742 2011.10

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人工内耳装用児の日本語統語構造の獲得年齢についての検討

藤吉昭江, 笠井紀夫, 菅谷明子, 福島邦博, 西崎和則

Otology Japan 21 ( 4 ) 740 - 740 2011.10

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両側人工内耳装用児の聴取と発音明瞭度の継時的変化

問田直美, 大森修平, 福島邦博, 片岡祐子, 菅谷明子, 西崎和則

Audiology Japan 54 ( 5 ) 369 - 370 2011.9

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【点耳薬の上手な使い方update】点耳抗菌薬は細菌の耐性化を引き起こすか

菅谷明子, 西崎和則

ENTONI ( 132 ) 55 - 60 2011.9

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当院で人工内耳手術を施行した児の言語発達の特徴

菅谷明子, 福島邦博, 笠井紀夫, 片岡祐子, 前田幸英, 長安吏江, 問田直美, 大森修平, 西崎和則

Audiology Japan 54 ( 5 ) 513 - 514 2011.9

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岡山県の軽度および中等度難聴児の補聴器購入費用助成に向けての取り組み軽度および中等度難聴児の補聴の現状と助成事業導入

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 増田游, 西崎和則

日本耳鼻咽喉科学会会報 114 ( 8 ) 731 - 736 2011.8

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J01099&link_issn=&doc_id=20110831340005&doc_link_id=1390282679989499904&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282679989499904&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif
【外来小児科医が知るべき子どもの聴覚障害】新生児聴覚スクリーニングの現状と問題点

菅谷明子, 福島邦博

外来小児科 14 ( 2 ) 119 - 124 2011.7

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人工内耳手術を施行した進行性および遅発性難聴症例の検討

片岡祐子, 福島邦博, 前田幸英, 菅谷明子, 長安吏江, 増田游, 西崎和則

日本耳鼻咽喉科学会会報 114 ( 6 ) 557 - 561 2011.6

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先天性高度聴覚障害児に対する日本語言語発達評価方法

笠井紀夫, 菅谷明子, 福島邦博

耳鼻咽喉科臨床補冊 ( 補冊131 ) 60 - 60 2011.6

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当院における再手術・追加手術を要した小児の人工内耳症例

菅谷明子, 福島邦博, 片岡祐子, 前田幸英, 笠井紀夫, 平井美紗都, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 186 - 186 2011.5

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急性乳様突起炎を契機に発見された真珠腫性中耳炎の1例

松本淳也, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 205 - 205 2011.5

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聴児および聴覚障害児における構文発達の検討

藤吉昭江, 田口智子, 笠井紀夫, 長安吏江, 菅谷明子, 福島邦博, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 199 - 199 2011.5

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内山下小学校難聴学級の50年

平井悠, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 129 - 129 2011.5

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軽度・中等度難聴児に対する「岡山県難聴児補聴器交付事業」導入1年間の実施状況

片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 193 - 193 2011.5

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中耳洗浄液CTP検出により術前診断が可能であった外リンパ瘻例

片岡祐子, 池園哲郎, 福島邦博, 結縁晃治, 濱田浩司, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 114 ( 4 ) 390 - 390 2011.4

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Vertigo and vestibular functions of two patients with EVA

SUGAYA Akiko, MAEDA Yukihide, KATAOKA Yuko, HIRAI Misato, FUKUSHIMA Kunihiro, NISHIZAKI Kazunori

31 ( 3 ) 299 - 306 2010.12

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抗真菌薬長期投与により救命し得た侵襲型蝶形骨洞真菌症の1症例

野山和廉, 折田頼尚, 菅谷明子, 平井美紗都, 三木健太郎

耳鼻咽喉科臨床補冊 ( 補冊128 ) 120 - 120 2010.6

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回転性めまいをきたした小児前庭水管拡大症の2例

菅谷明子, 前田幸英, 片岡祐子, 平井美紗都, 福島邦博, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊128 ) 117 - 117 2010.6

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IL-1受容体アンタゴニストが感音難聴の治療に奏功したクリオピリン関連症候群の1例

平井美紗都, 菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 福島邦博, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊128 ) 109 - 109 2010.6

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前庭機能検査を施行した小児の前庭水管拡大症の2例.

菅谷明子, 前田幸英, 片岡祐子, 平井美紗都, 福島邦博, 西﨑和則

小児耳鼻咽喉科 31 ( 3 ) 101 - 108 2010

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当科で経験した頸部交感神経鞘腫の3例

菅谷明子, 折田頼尚, 三木健太郎, 中井貴世子, 平井美紗都, 園部紀子

耳鼻咽喉科・頭頸部外科 81 ( 1 ) 65 - 70 2009.1

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めまいが初発症状であった巨大小脳動静脈奇形例

平井美紗都, 折田頼尚, 菅谷明子, 妹尾一範, 結縁晃治

耳鼻咽喉科臨床 101 ( 10 ) 759 - 764 2008.10

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一側性多発性耳下腺多形腺腫症例の検討

折田頼尚, 三木健太郎, 菅谷明子, 浜家一雄

口腔・咽頭科 = Stomato-pharyngology 21 ( 1 ) 84 - 84 2008.8

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正中下口唇下顎骨舌切断法にて摘出した左舌根部乳頭状嚢胞腺癌の1例

菅谷明子, 井口郁雄, 綾田展明, 江草憲太郎, 堀康高, 三木健太郎, 折田頼尚

岡山済生会総合病院雑誌 39 52 - 57 2007.12

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Presentations

あなたの小児難聴診療をブラッシュアップ！－こどもの聴こえと未来を守るためにー

第20回日本小児耳鼻咽喉科学会総会・学術講演会 2025.6.19

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Event date： 2025.6.19 - 2025.6.20

Language：Japanese

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聴覚障害当事者による聴覚障害者就労・就労継続支援に関するチェックリストの検証

第126回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会 2025.5.28

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Event date： 2025.5.28 - 2025.5.30

Language：Japanese Presentation type：Oral presentation (general)

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Symposium 1：今から始めるこどもから大人への移行支援 Invited

菅谷明子

第18回日本小児耳鼻咽喉科学会総会・学術講演会 2023.11.9

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Event date： 2023.11.9 - 2023.11.10

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難聴をめぐる最近の話題

菅谷明子

聴覚障害児支援研究会 2024.11.20

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知ってますか？難聴の原因と対策

菅谷明子

コクレア市民公開講座 2024.7.7

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岡山大学病院の人工内耳医療 -手術の実際と当科の取り組みについて-

菅谷明子

岡山県耳鼻咽喉科領域講習オンラインセミナー 2022.9.22

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日常診療で遭遇する中耳炎の診断と治療 -難聴との関連も含めて-

菅谷明子

Kyorin耳鼻咽喉科WEBセミナー 2022.7.5

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人工内耳装用者の生涯にわたるサポートの重要性 -就労支援について-

菅谷明子

第6回人工内耳友の会ACITA岡山支部総会 2022.5.22

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人工内耳について学ぶ

菅谷明子

岡山県聴覚障害者関係地域ボランティア研修会 2022.5.21

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カタカナ書字困難に対する介入を行った軽度難聴児の1例

菅谷明子

第120回日本耳鼻咽喉科学会総会・学術講演会 2019

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異なる聴力像を示したGJB2遺伝子変異による難聴の双胎児例

菅谷明子

第64回日本聴覚医学会 2019

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小児における人工内耳術後のマッピング開始時期の検討

菅谷明子

第63回日本聴覚医学会 2018

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新生児聴覚スクリーニング実施における費用対策効果の検討

第118回日本耳鼻咽喉科学会通常総会・学術講演会 2017

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デキサメタゾン投与後の蝸牛遺伝子発現パターンの経時的・動態的検討

第118回日本耳鼻咽喉科学会通常総会・学術講演会 2017

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中耳炎により外科的処置を要した小児人工内耳装用例の検討

第12回日本小児耳鼻咽喉科学会総会・学術講演会 2017

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次世代シークエンサー(NGS)を併用した難聴遺伝子検査が有用であった3例

第41回日本遺伝カウンセリング学会 2017

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めまいを伴いVZV陽性の小児急性感音難聴の1例

第17回岡山県地方部会学術講演会 2017

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MRI検査後に人工内耳インプラントのマグネットの反転を来たした2例

菅谷明子

2016

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急性感音難聴モデルマウスへのステロイド投与後の内耳遺伝子発現 - RNA-seqとDNAマイクロアレイを用いた解析 -

第26回日本耳科学会総会・学術講演会 2016

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初回手術後に長期間経過して対側人工内耳埋込術を施行された高度感音難聴児6例の検討

第117回日本耳鼻咽喉科学会総会 2016

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人工内耳装用前の早期補聴が言語発達に与える効果の検証

第11回日本小児耳鼻咽喉科学会 2016

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“高齢者の会話の聞き取り困難”と中枢聴覚機能検査について

日本耳鼻咽喉科学会第42回中国四国地方部会連合学会 2016

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頸部リンパ管腫に合併した滲出性中耳炎の1例

第78回耳鼻咽喉科臨床学会総会および学術講演会 2016

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岡山県における小児難聴例の診断時期の検討

第11回日本小児耳鼻咽喉科学会 2016

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人工内耳装用児の英語学習における実態調査

第26回日本耳科学会総会・学術講演会 2016

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次世代シークエンサーを併用した難聴遺伝子検査が有用であった2例

第42回中国地方部会連合講演会 2016

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両側高度難聴・前庭機能廃絶をきたした中枢神経原発リンパ腫の1症例

第42回中国地方部会連合講演会 2016

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当科で経過を観察した両側聴神経鞘腫の2例

第16回岡山県地方部会学術講演会 2016

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純音聴力閾値上昇を呈した聴覚情報処理障害の小児例

第117回日本耳鼻咽喉科学会総会 2016

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乳幼児鼓膜インピーダンス測定における1000Hz tympanometryの有用性の検討

第26回日本耳科学会総会・学術講演会 2016

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当科における成人人工内耳症例の検討 - 埋め込み時65歳以上の術後成績について -

第116回日本耳鼻咽喉科学会総会 2015

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当科における小児の両側人工内耳症例50例の検討

第10回日本小児耳鼻咽喉科学会総会・学術講演会 2015

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難聴遺伝子診断と人工内耳

平成26年度難聴遺伝子の研究会 2015

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成人人工内耳装用者のピッチ弁別およびプロソディーによる感情理解に関する研究

第25回日本耳科学会総会・学術講演会 2015

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人工内耳埋め込み術を施行した Waardenburg 症候群の 2 例

第10回日本小児耳鼻咽喉科学会総会・学術講演会 2015

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言語評価の後に補聴器装用・言語訓練の開始に至った中等度難聴の一例

第10回日本小児耳鼻咽喉科学会総会・学術講演会 2015

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当科における急性低音障害型感音難聴の治療と予後の検討

第116回日本耳鼻咽喉科学会総会 2015

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岡山県内胃瘻造設術施行施設へのアンケートからみる嚥下機能評価における耳鼻咽喉科医の役割

第116回日本耳鼻咽喉科学会総会 2015

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複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリングの経験

第39回日本遺伝カウンセリング学会 2015

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蝸牛におけるステロイド作用機序 - Charcot-Marie-Tooth neuropathy関連蛋白, Myelin protein zeroの制御 -

第25回日本耳科学会総会・学術講演会 2015

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人工内耳装用者のスポーツ時における問題に関するアンケート調査

第25回日本耳科学会総会・学術講演会 2015

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再発性多発軟骨炎の2症例

日本耳鼻咽喉科学会第41回中国地方部会連合講演会 2015

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残存聴力活用型人工内耳（EAS : electric acoustic stimulation）が有効であった高音急墜型感音難聴の1例

日本耳鼻咽喉科学会第41回中国地方部会連合講演会 2015

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福山型先天性筋ジストロフィー患児に対する人工内耳埋め込み術

第116回日本耳鼻咽喉科学会総会 2015

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脳表ヘモジデリン沈着症に伴う進行性高度感音難聴に対し人工内耳埋め込み術を行い良好な経過を得た1例

第77回耳鼻咽喉科臨床学会学術講演会 2015

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成人期になり診断したAuditory Processing Disorderの1症例

第25回日本耳科学会総会・学術講演会 2015

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顔面神経麻痺, 感音難聴を呈した髄膜癌腫症の2例

第25回日本耳科学会総会・学術講演会 2015

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2年以上聴力経過を観察した小児心因性難聴の7例

第60回日本聴覚医学会 2015

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岡山県における軽度・中等度難聴児補聴器助成事業実施状況の検討

第115回日本耳鼻咽喉科学会総会 2014

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岡山大学耳鼻咽喉科における補聴器外来の現況-高齢者の補聴に関連して-

第115回日本耳鼻咽喉科学会総会 2014

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回転性めまい発作を呈した顔面神経鞘腫の1例

日本耳鼻咽喉科学会第40回中国四国地方部会連合学会 2014

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当科で経験したBOR症候群の家族例

第38回日本遺伝カウンセリング学会 2014

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Research Projects

音韻障害を合併した人工内耳装用児の早期診断および介入のための戦略

Grant number：24K12674 2024.04 - 2027.03

日本学術振興会科学研究費助成事業基盤研究(C)

菅谷明子

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Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

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一側性聴覚障害の評価手法の標準化と社会参加を促進する手法に関する研究開発

2024.04 - 2027.03

日本医療研究開発機構障害者対策総合研究開発事業

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Authorship：Coinvestigator(s)

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先天性および若年性の視覚聴覚二重障害の難病に対する医療と支援に関する研究

2024.04

厚生労働科学研究費補助金難治性疾患等政策研究事業

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Authorship：Coinvestigator(s)

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聴覚障害者の就労支援チェックリストに基づいた就労マッチング支援手法の開発および遮音材・補聴援助システムによる住居支援の効果の検証

Grant number：23dk0310122h0001 2023.05 - 2026.03

日本医療研究開発機構 AMED 身体・知的・感覚器障害分野（障害者対策総合研究開発事業）

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Authorship：Principal investigator

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聴覚障害者の社会参加を促進するための手法に関する研究

2020 - 2023

聴覚障害児・者の円滑な社会参加に資する施策立案に関する研究(AMED) 研究分担者

菅谷明子

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Authorship：Coinvestigator(s)

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急性感音難聴の病態と治療における内耳免疫メカニズム -内耳遺伝子転写網の解析-

2019.04 - 2022.03

科学研究費補助金(基盤Ｃ)研究分担者

前田幸英, 菅谷明子

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Authorship：Coinvestigator(s) Grant type：Competitive

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難聴児における音韻障害の遺伝学的診断法と言語発達評価法の開発

2018.04 - 2021.03

科学研究費補助金(若手研究) 研究代表者

菅谷明子

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Authorship：Principal investigator Grant type：Competitive

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「難治性聴覚障害に関する調査研究班」

2017.04 - 2020.03

厚生労働科学研究費補助金難治性疾患等政策研究事業研究協力者

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Grant type：Competitive

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急性感音難聴の分子病態と治療の動態的解析-次世代シークエンスでの統合遺伝子解析-

2016.04 - 2019.03

科学研究費補助金(基盤Ｃ）研究分担者

前田幸英, 菅谷明子

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Authorship：Coinvestigator(s) Grant type：Competitive

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原因診断に基づく小児難聴の治療・療育システム構築に関する研究

2016.04 - 2019.03

日本医療研究開発機構（AMED）長寿・障害総合研究事業障害者対策総合研究開発事業(研究分担者）

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Authorship：Coinvestigator(s) Grant type：Competitive

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人工内耳装用児の英語学習における実態調査ならびに介入手法に関する研究

2015.04 - 2018.03

科学研究費補助金（若手研究B) 研究代表者

菅谷明子

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Authorship：Principal investigator Grant type：Competitive

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乳幼児の疾患疫学を踏まえたスクリーニング等の効果的実施に関する研究

2015.04 - 2018.03

日本医療研究開発機構（AMED）（研究協力者）

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Grant type：Competitive

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乳幼児中耳貯留液の診断における1000Hzティンパノメトリーの有用性の検討

2014.04 - 2017.03

科学研究費補助金(基盤Ｃ）研究分担者

片岡祐子

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Grant type：Competitive

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学習障害関連遺伝子をターゲットとした人工内耳予後予測因子に関する研究

Grant number：25462641 2013.04 - 2014.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

福島邦博, 前田幸英, 片岡祐子, 菅谷明子

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Authorship：Coinvestigator(s)

Grant amount：\4940000 （ Direct expense: \3800000 、 Indirect expense：\1140000 ）

小児先天性難聴に対しては、現在人工内耳埋め込み術が早期（１歳前後）から適応されることが多くなっている。しかし、人工内耳装用児のすべてが順調な言語発達を示すとは限らず、その言語発達には個人差が大きい。特に低年齢の人工内耳装用児でその言語発達予後を予測することは容易ではなく、より適切な手法の開発が望まれている。遺伝子診断は、従来難聴の原因を探すために主として用いられてきたが、近年では学習障害などの原因遺伝子も明らかにされており、この技術を用いて人工内耳術後の言語発達予後予測を行うことをこの研究の目標とした。当面、その予備実験として難聴のない言語発達障害児童（特異的言語発達障害）において、既に海外で報告されている言語発達に影響を与える遺伝子での変異の有無を検討した。末梢血から採取したDNAを用い、パラレルシークエンス法によって候補遺伝子（FOXP2,DYA1C１,DCDC2, KIAA0319, ROBO1）の全エクソンにおける変異を検討した。意味のある変異を検出することはできなかった。日本語話者での遺伝子変異は人種的ないしは言語的な違いにより、欧米での遺伝子変異とパターンが異なる可能性があり、まず本邦患者を元にした新たな言語発達障害関連遺伝子の解析が望まれると考えられた。

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聴覚障害児の言語リハビリ長期予後に関する追跡調査

2013.04 - 2014.03

厚生労働省科学研究費補助金(研究協力者）

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Grant type：Competitive

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「感覚器障害戦略研究（聴覚分野）」

2010.04 - 2012.03

厚生労働省科学研究費補助金 (研究協力者）

福島邦博、菅谷明子

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Grant type：Competitive

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Class subject in charge

Otolaryngology （2024academic year） Second semester - 木3
Otolaryngology （2023academic year） Second semester - 木3

Social Activities

岡山県身体障害者更生相談所判定医

Role(s)：Advisor

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大元寮診療所岡山かなりや学園嘱託医

Role(s)：Organizing member

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