Faculty Profiles - KAJITA Ai

写真a

KAJITA Ai

Organization

Scheduled update Assistant Professor

External link

Degree

医学博士 ( 岡山大学大学院医歯薬学総合研究科 )

Research Interests

自然免疫
皮膚ウイルス感染症
表皮角化細胞

Research Areas

Life Science / Dermatology

Research History

岡山大学病院

2019.4

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Country：Japan

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Papers

Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes Reviewed

Ai Kajita, Shin Morizane, Tetsuya Takiguchi, Takenobu Yamamoto, Masao Yamada, Keiji Iwatsuki

JOURNAL OF INVESTIGATIVE DERMATOLOGY 135 ( 8 ) 2005 - 2011 2015.8

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/jid.2015.125

Web of Science

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Elevated expression of interleukin‐6 (<scp>IL</scp>‐6) and serum amyloid A (<scp>SAA</scp>) in the skin and the serum of recessive dystrophic epidermolysis bullosa: Skin as a possible source of <scp>IL</scp>‐6 through Toll‐like receptor ligands and <scp>SAA</scp> Reviewed

Yoshio Kawakami, Ai Kajita, Ken‐Ichi Hasui, Yoshihiro Matsuda, Keiji Iwatsuki, Shin Morizane

Experimental Dermatology 33 ( 3 ) 2024.3

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Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

The effect of persistent skin inflammation on extracutaneous organs and blood is not well studied. Patients with recessive dystrophic epidermolysis bullosa (RDEB), a severe form of the inherited blistering skin disorder, have widespread and persistent skin ulcers, and they develop various complications including anaemia, hyperglobulinaemia, hypoalbuminaemia and secondary amyloidosis. These complications are associated with the bioactivities of IL‐6, and the development of secondary amyloidosis requires the persistent elevation of serum amyloid A (SAA) level. We found that patients with RDEB had significantly higher serum levels of IL‐6 and SAA compared to healthy volunteers and patients with psoriasis or atopic dermatitis. Both IL‐6 and SAA were highly expressed in epidermal keratinocytes and dermal fibroblasts of the skin ulcer lesions. Keratinocytes and fibroblasts surrounding the ulcer lesions are continuously exposed to Toll‐like receptor (TLR) ligands, pathogen‐associated and damage‐associated molecular pattern molecules. In vitro, TLR ligands induced IL‐6 expression via NF‐κB in normal human epidermal keratinocytes (NHEKs) and dermal fibroblasts (NHDFs). SAA further induced the expression of IL‐6 via TLR1/2 and NF‐κB in NHEKs and NHDFs. The limitation of this study is that NHEKs and NHDFs were not derived from RDEB patients. These observations suggest that TLR‐mediated persistent skin inflammation might increase the risk of IL‐6‐related systemic complications, including RDEB.

DOI： 10.1111/exd.15040

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Vulvar Crohn's disease presenting with multiple exophytic nodules and labial swelling: A case report. Reviewed International journal

Ai Kajita, Yoshio Kawakami, Sakiko Hiraoka, Junko Haraga, Shin Morizane

The Journal of dermatology 2023.8

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Authorship：Lead author Language：English

DOI： 10.1111/1346-8138.16918

PubMed

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A case of Japanese spotted fever with asymptomatic cerebral infarction and pulmonary artery embolism. Reviewed International journal

Eriko Fujii, Osamu Yamasaki, Ai Kajita, Yuki Akamatsu, Tomoko Kawamoto, Tomoko Miyake, Koh Tadokoro, Yoichi Takaya, Shin Morizane

European journal of dermatology : EJD 33 ( 1 ) 45 - 47 2023.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1684/ejd.2023.4413

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MRIにて大腿骨と腸骨に骨髄浮腫がみられた下肢の線状強皮症の1例 Reviewed

佐藤志帆, 梶田藍, 山崎修, 中原龍一, 森実真

西日本皮膚科 84 ( 6 ) 521 - 525 2022.12

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Language：Japanese Publisher：日本皮膚科学会-西部支部

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Novel homozygous missense mutation c.1654G>T in the ALOX12B gene causing congenital ichthyosiform erythroderma. Reviewed International journal

Kotoe Mae, Yoshio Kawakami, Ai Kajita, Takuya Takeichi, Tatsuhiro Noda, Yoji Hirai, Masashi Akiyama, Shin Morizane

The Journal of dermatology 50 ( 1 ) e37-e38 2022.10

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Authorship：Corresponding author Language：English

DOI： 10.1111/1346-8138.16601

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Impetigo herpetiformis successfully treated with brodalumab. Reviewed International journal

Yumi Nakai, Himino Ashida, Ai Kajita, Emi Yokoyama, Kazumitsu Sugiura, Shin Morizane

The Journal of dermatology 49 ( 4 ) e149-e150 2022.4

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Language：English

DOI： 10.1111/1346-8138.16285

PubMed

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Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes Reviewed International journal

Kota Tachibana, Nina Tang, Hitoshi Urakami, Ai Kajita, Mina Kobashi, Hayato Nomura, Minori Sasakura, Satoru Sugihara, Fan Jiang, Nahoko Tomonobu, Masakiyo Sakaguchi, Mamoru Ouchida, Shin Morizane

International Journal of Molecular Sciences 22 ( 23 ) 12659 - 12659 2021.11

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Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Interleukin (IL) 23 (p19/p40) plays a critical role in the pathogenesis of psoriasis and is upregulated in psoriasis skin lesions. In clinical practice, anti-IL-23Ap19 antibodies are highly effective against psoriasis. IL-39 (p19/ Epstein-Barr virus-induced (EBI) 3), a newly discovered cytokine in 2015, shares the p19 subunit with IL-23. Anti-IL-23Ap19 antibodies may bind to IL-39; also, the cytokine may contribute to the pathogenesis of psoriasis. To investigate IL23Ap19- and/or EBI3-including cytokines in psoriatic keratinocytes, we analyzed IL-23Ap19 and EBI3 expressions in psoriasis skin lesions, using immunohistochemistry and normal human epidermal keratinocytes (NHEKs) stimulated with inflammatory cytokines, using quantitative real-time polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and liquid chromatography-electrospray tandem mass spectrometry (LC-Ms/Ms). Immunohistochemical analysis showed that IL-23Ap19 and EBI3 expressions were upregulated in the psoriasis skin lesions. In vitro, these expressions were synergistically induced by the triple combination of tumor necrosis factor (TNF)-α, IL-17A, and interferon (IFN)-γ, and suppressed by dexamethasone, vitamin D3, and acitretin. In ELISA and LC-Ms/Ms analyses, keratinocyte-derived IL-23Ap19 and EBI3, but not heterodimeric forms, were detected with humanized anti-IL-23Ap19 monoclonal antibodies, tildrakizumab, and anti-EBI3 antibodies, respectively. Psoriatic keratinocytes may express IL-23Ap19 and EBI3 proteins in a monomer or homopolymer, such as homodimer or homotrimer.

DOI： 10.3390/ijms222312659

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Staphylococcal enterotoxin B- and lipopolysaccharide-induced toxic shock syndrome in a burn patient. Reviewed International journal

Osamu Yamasaki, Satoru Sugihara, Ai Kajita, Emi Yokoyama, Tomoko Miyake, Yoji Hirai, Shin Morizane

The Journal of dermatology 48 ( 4 ) 547 - 550 2021.4

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Toxic shock syndrome (TSS) is caused by toxic shock syndrome toxin 1 or enterotoxins secreted by Staphylococcus aureus. Lipopolysaccharide (LPS) has also been shown to play a major role in the development of sepsis. Staphylococcal superantigens and LPS operate synergistically in conditioning cytokine release and lethal shock in mice. An 80-year-old woman was admitted because of a 20% mixed-depth flame burn. Despite two excisions and grafts, necrotic ulcers with methicillin-resistant Staphylococcus aureus (MRSA) colonization remained. On the 7th day after the operation, she developed shock with an erythematous rash. Blood examination revealed evidence of disseminated intravascular coagulation, and liver and renal dysfunction. A blood culture revealed a staphylococcal enterotoxin B (SEB)-producing strain of MRSA and Klebsiella pneumoniae. The septic symptoms were prolonged, but the condition gradually improved with extensive treatment. T-cell receptor analysis demonstrated a marked accumulation of SEB-mediated Vβ T cells. Stimulation of peripheral blood mononuclear cells in the recovery phase with SEB and LPS induced additive effects on tumor necrosis factor-α, interferon-γ, and interleukin-6 production. Although the present case did not fulfill the clinical criteria for TSS, the additive effects of SEB and LPS might have caused the severe septic shock.

DOI： 10.1111/1346-8138.15729

PubMed

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Solitary fibrous tumor of the inguinal region displaying heterogeneous echogenicity and its correlation with histopathologic findings Reviewed

Ai Kajita, Yoshio Kawakami, Tomoko Miyake, Wakako Oda, Osamu Yamasaki, Shin Morizane

Our Dermatology Online 11 ( 4 ) 432 - 433 2020.11

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Authorship：Lead author Publishing type：Research paper (scientific journal) Publisher：Our Dermatology Online

DOI： 10.7241/ourd.20204.28

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Multifaceted Analyses of Epidermal Serine Protease Activity in Patients with Atopic Dermatitis Reviewed

Hayato Nomura, Mutsumi Suganuma, Takuya Takeichi, Michihiro Kono, Yuki Isokane, Ko Sunagawa, Mina Kobashi, Satoru Sugihara, Ai Kajita, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Masashi Akiyama, Shin Morizane

International Journal of Molecular Sciences 21 ( 3 ) 913 - 913 2020.1

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Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The serine proteases kallikrein-related peptidase (KLK) 5 and KLK7 cleave cell adhesion molecules in the epidermis. Aberrant epidermal serine protease activity is thought to play an important role in the pathogenesis of atopic dermatitis (AD). We collected the stratum corneum (SC) from healthy individuals (n = 46) and AD patients (n = 63) by tape stripping and then measuring the trypsin- and chymotrypsin-like serine protease activity. We also analyzed the p.D386N and p.E420K of SPINK5 variants and loss-of-function mutations of FLG in the AD patients. The serine protease activity in the SC was increased not only in AD lesions but also in non-lesions of AD patients. We found, generally, that there was a positive correlation between the serine protease activity in the SC and the total serum immunoglobulin E (IgE) levels, serum thymus and activation-regulated chemokine (TARC) levels, and peripheral blood eosinophil counts. Moreover, the p.D386N or p.E420K in SPINK5 and FLG mutations were not significantly associated with the SC’s serine protease activity. Epidermal serine protease activity was increased even in non-lesions of AD patients. Such activity was found to correlate with a number of biomarkers of AD. Further investigations of serine proteases might provide new treatments and prophylaxis for AD.

DOI： 10.3390/ijms21030913

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An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. Reviewed International journal

Tamayo Yamashita, Toshihisa Hamada, Yuka Maruta, Ai Kajita, Yoji Hirai, Shin Morizane, Soichiro Watanabe, Kazumitsu Sugiura, Keiji Iwatsuki

International journal of dermatology 58 ( 3 ) 350 - 353 2019.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/ijd.14141

PubMed

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直接作用型抗ウイルス薬によるC型肝炎治療後も症状が持続していた形質細胞性口唇炎の1例 Reviewed

永瀬喬之, 梶田藍, 小田和歌子, 原裕一, 川上佳夫

皮膚科の臨床 61 ( 3 ) 419 - 422 2019.3

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Language：Japanese Publisher：金原出版(株)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J01266&link_issn=&doc_id=20190320030037&doc_link_id=10.18888%2Fhi.0000001277&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000001277&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
Toll-like receptor signalling induces the expression of serum amyloid A in epidermal keratinocytes and dermal fibroblasts Reviewed International journal

S. Morizane, A. Kajita, K. Mizuno, T. Takiguchi, K. Iwatsuki

Clinical and Experimental Dermatology 44 ( 1 ) 40 - 46 2019.1

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Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

BACKGROUND: Toll-like receptors (TLRs) play critical roles in innate immune response by sensing pathogen- or damage-associated molecular patterns. Epidermal keratinocytes and dermal fibroblasts also produce proinflammatory cytokines and chemokines under stimulation with TLR ligands. Serum amyloid A (SAA) is an essential factor in the pathogenesis of secondary amyloidosis, and also has immunomodulatory functions. SAA are produced mainly by hepatocytes but also by a variety of cells, including immune cells, endothelial cells, synoviocytes, and epidermal keratinocytes. However, SAA expression in human dermal fibroblasts has not been shown to date. AIM: To investigate the effect of TLR ligands on SAA expression in epidermal keratinocytes and dermal fibroblasts. METHODS: We investigated whether TLR ligands induce the expression of SAA in normal human epidermal keratinocytes (NHEKs) and normal human dermal fibroblasts (NHDFs) by real-time quantitative PCR and ELISA. The effect of SAA on its own expression in NHDFs was also studied. RESULTS: SAA expression was induced via nuclear factor-κB by TLR1/2, 3, 5 and 2/6 ligands in NHEKs. In NHDFs, TLR1/2 and TLR2/6 ligands increased SAA expression. SAA further induced its own expression via TLR1/2 and NF-κB in NHDFs, as previously reported for NHEKs. CONCLUSIONS: Our results provide new evidence that the skin's innate immune response contributes to the production of SAA, which might lead to an increased risk of systemic complications such as secondary amyloidosis of recessive dystrophic epidermolysis bullosa.

DOI： 10.1111/ced.13604

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【代謝異常症・沈着症】Urate Milkが透視された痛風結節の1例 Reviewed

篠倉美理, 光井聖子, 梶田藍, 湧田暁子, 川上佳夫

皮膚科の臨床 60 ( 9 ) 1337 - 1340 2018.8

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J01266&link_issn=&doc_id=20180814140011&doc_link_id=10.18888%2Fhi.0000000911&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000000911&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
下顎部に生じたPilonidal Sinus Reviewed

川上佳夫, 梶田藍

皮膚科の臨床 60 ( 9 ) 1442 - 1443 2018.8

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Language：Japanese Publisher：金原出版(株)

症例は69歳男性で、2ヵ月前に下顎部の皮下硬結を自覚し、1ヵ月前より排膿を認めた。受診時には下顎部に下床との可動性を有する紅色結節(8mm大)があり、中心部の瘻孔と少量の透明な滲出液を認めたが、自発痛はなく、一般細菌培養は陰性であった。毛包炎、癰、感染性粉瘤などを考えて抗菌薬の外用、内服を行うも局所の炎症症状は改善せず、発症から1年2ヵ月後に切除生検を行ったところ、病理組織像では皮下脂肪組織に重層扁平上皮で覆われた嚢腫と、内腔に多数の毛髪断面を認めた。また、嚢腫の辺縁には毛髪断面と異物巨細胞の浸潤がみられたことより、pilonidal sinusと診断した。術後5ヵ月経過現在、再発は認めていない。

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【細菌・抗酸菌感染症】手掌に顕著な紅斑が認められたMRSAによるToxin-mediated Diseaseの1例 Reviewed

中井友美, 梶田藍, 川上佳夫, 佐々木恵里佳, 菅波由有, 山田晴士, 平野秀一郎, 河内哲, 井上智

皮膚科の臨床 60 ( 8 ) 1187 - 1190 2018.7

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J01266&link_issn=&doc_id=20180719160010&doc_link_id=10.18888%2Fhi.0000000860&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000000860&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
【ウイルス感染症】高齢者に生じたコクサッキーウイルスA6型による手足口病 Reviewed

川上佳夫, 梶田藍

皮膚科の臨床 60 ( 4 ) 479 - 482 2018.4

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J01266&link_issn=&doc_id=20180416200014&doc_link_id=10.18888%2Fhi.0000000664&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000000664&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
免疫チェックポイント阻害剤から緩和治療へ移行した進行期悪性黒色腫の検討 Reviewed

梶田藍, 山崎修, 加持達弥, 梅村啓史, 岩月啓氏

西日本皮膚科 80 ( 1 ) 51 - 55 2018.2

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Authorship：Lead author Language：Japanese Publisher：日本皮膚科学会-西部支部

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01003&link_issn=&doc_id=20180306270012&doc_link_id=10.2336%2Fnishinihonhifu.80.51&url=https%3A%2F%2Fdoi.org%2F10.2336%2Fnishinihonhifu.80.51&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif
Cathelicidin antimicrobial peptide LL ‐37 augments interferon‐β expression and antiviral activity induced by double‐stranded RNA in keratinocytes Reviewed International journal

T. Takiguchi, S. Morizane, T. Yamamoto, A. Kajita, K. Ikeda, K. Iwatsuki

British Journal of Dermatology 171 ( 3 ) 492 - 498 2014.9

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Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

BACKGROUND: Cathelicidin antimicrobial peptide LL-37 has the capacity to kill a wide range of microbes and to modify host immunity. Recently, our group observed that the activation of keratinocytes by LL-37 and DNA greatly increases interferon (IFN)-β through Toll-like receptor (TLR)9. However, the effect of LL-37 on the induction of IFN-β through TLR3, a sensor of double-stranded (ds) RNA, in keratinocytes is not well known. OBJECTIVES: To investigate whether LL-37 could affect TLR3 signalling and antiviral activity in normal human epidermal keratinocytes (NHEKs). METHODS: We investigated the production of IFN-β in NHEKs stimulated with a TLR3 ligand, poly (I:C), in the presence of LL-37. To examine the effect of LL-37 and poly (I:C) on antiviral activity, a virus plaque assay using herpes simplex (HS) virus type-1 was carried out. The uptake of poly (I:C) conjugated with fluorescein isothiocyanate (FITC) into the keratinocytes was observed in the presence of LL-37. Immunostaining for TLR3 and LL-37 was performed using skin samples from HS. RESULTS: LL-37 and poly (I:C) synergistically induced the expression of IFN-β in NHEKs. Furthermore, co-stimulation with LL-37 and poly (I:C) significantly decreased the viral plaque numbers compared with poly (I:C) or LL-37 alone. LL-37 enhanced the uptake of FITC-conjugated poly (I:C) into cells. Immunohistochemical analysis demonstrated that the expression of TLR3 and LL-37 is upregulated in HS lesions. CONCLUSIONS: Our findings suggest that LL-37 augments the antiviral activity induced by dsRNA in keratinocytes, which may contribute to the innate immune response to cutaneous viral infections such as HS.

DOI： 10.1111/bjd.12942

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bjd.12942
眼底綿花様白斑を合併した全身性エリテマトーデスの1例眼合併症と疾患活動性との関連性に関する検討 Reviewed

杉生真帆, 青山裕美, 梶田藍, 竹島千夏, 濱田利久, 松尾俊彦, 赤塚俊文, 岩月啓氏

臨床皮膚科 66 ( 12 ) 960 - 964 2012.11

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2012&ichushi_jid=J01559&link_issn=&doc_id=20121112150005&doc_link_id=10.11477%2Fmf.1412103457&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1412103457&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis Reviewed International journal

Shin Morizane, Kenshi Yamasaki, Ai Kajita, Kazuko Ikeda, Maosheng Zhan, Yumi Aoyama, Richard L. Gallo, Keiji Iwatsuki

Journal of Allergy and Clinical Immunology 130 ( 1 ) 259 - 261.e1 2012.7

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.jaci.2012.03.006

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下眼瞼に腫瘤を形成し、顔面に丘疹が出没した菌状息肉症 Reviewed

梶田藍, 山崎修, 朝倉昇司, 山鳥一郎, 市村浩一, 吉野正

西日本皮膚科 72 ( 5 ) 473 - 477 2010.10

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2010&ichushi_jid=J01003&link_issn=&doc_id=20101020390008&doc_link_id=10.2336%2Fnishinihonhifu.72.473&url=https%3A%2F%2Fdoi.org%2F10.2336%2Fnishinihonhifu.72.473&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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Books

知っておきたい歯科における医療安全対策 : 大学病院での医科・歯科双方の視点から

白井, 肇, 飯田, 征二, 前田, 嘉信, 塚原, 宏一, 窪木, 拓男（ Role： Contributor , 皮膚科の立場からー金属アレルギー患者における連携）

デンタルダイヤモンド社 2025.10 （ ISBN:9784885106347 ）

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Total pages：239p Language：Japanese

CiNii Books

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抗エンテロウイルス71型抗体の上昇を認め重症手足口病と考えられた1例

竹中美結, 砂川滉, 水田康生, 杉原悟, 梶田藍, 三宅智子, 平井陽至, 川上佳夫, 森実真, 須山敦仁, 川口満里奈, 大國皓平, 中本健太, 萩谷英大, 松浦能子, 漆原嘉奈子

日本皮膚科学会雑誌 135 ( 11 ) 2327 - 2327 2025.10

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新型コロナウイルス感染症(COVID-19)罹患後症状にみられる皮膚症状の臨床的特徴について

横山恵美, 川上佳夫, 三宅智子, 梶田藍, 平井陽至, 神野泰輔, 立花宏太, 大塚文男, 森実真

西日本皮膚科 87 ( 3 ) 295 - 296 2025.6

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ウパダシチニブによる潰瘍性大腸炎治療後に,皮膚症状が改善した後天性反応性穿孔性膠原線維症の1例

別木祐介, 川上佳夫, 梶田藍, 三宅智子, 森実真, 平岡佐規子

日本皮膚科学会雑誌 135 ( 5 ) 1353 - 1353 2025.5

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Language：Japanese Publisher：(公社)日本皮膚科学会

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皮膚筋炎の再燃と鑑別を要した頭部顔面接触皮膚炎の1例

横山恵美, 川上佳夫, 三宅智子, 梶田藍, 勝山恵理, 森実真

日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集 54回 244 - 244 2024.12

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先天性表皮水疱症におけるIL-6を介した慢性炎症の病態についての検討

川上佳夫, 梶田藍, 蓮井謙一, 松田吉弘, 岩月啓氏, 森実真

日本皮膚科学会雑誌 134 ( 9 ) 2307 - 2307 2024.8

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G-CSF・PTHrP産生胸部有棘細胞癌の1例

池田賢太, 梶田藍, 青雅一, 濱田龍正, 高野英実

日本皮膚科学会雑誌 134 ( 8 ) 2122 - 2122 2024.7

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関節リウマチと自己免疫性肝炎に合併した壊疽性膿皮症にアダリムマブを投与し植皮術を施行した1例

砂川滉, 梶田藍, 佐藤由規, 村田愛美, 神野泰輔, 立花宏太, 森実真, 前田恵美, 栗林怜実, 勝山恵理, 藤井江利子, 澤井希望, 岡崎布佐子

日本皮膚科学会雑誌 134 ( 8 ) 2121 - 2121 2024.7

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プレドニゾロンとメトトレキサート内服併用療法が有効であった線状強皮症の小児例

村田愛美, 梶田藍, 三宅智子, 川上佳夫, 森実真, 八代将登, 浅越健治

日本皮膚科学会雑誌 134 ( 6 ) 1708 - 1708 2024.5

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四肢に暗紅色斑を呈した多血症の1例

藤田周作, 吉田将平, 浦田知宏, 梶田藍, 安原千夏

日本皮膚科学会雑誌 133 ( 8 ) 1885 - 1885 2023.7

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扁平コンジローマなど多彩な発疹を呈した第2期梅毒の1例

池田賢太, 梶田藍, 木村宣彦

日本皮膚科学会雑誌 133 ( 8 ) 1894 - 1894 2023.7

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【紅皮症の考え方と捉え方】膿疱化・紅皮症化をきたし急性呼吸窮迫症候群を併発した尋常性乾癬

芦田日美野, 横山恵美, 谷口暁彦, 梶田藍, 浦上仁志, 森実真

皮膚病診療 45 ( 2 ) 142 - 146 2023.2

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新規ALOX12B遺伝子病的バリアントを認めた先天性魚鱗癬様紅皮症の1例

前琴絵, 梶田藍, 川上佳夫, 森実真, 野田達宏, 武市拓也, 秋山真志

日本皮膚科学会雑誌 133 ( 2 ) 262 - 262 2023.2

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MRIにて大腿骨と腸骨に骨髄浮腫がみられた下肢の線状強皮症の1例

佐藤志帆, 梶田藍, 山崎修, 中原龍一, 森実真

西日本皮膚科 84 ( 6 ) 521 - 525 2022.12

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01003&link_issn=&doc_id=20230113360011&doc_link_id=10.2336%2Fnishinihonhifu.84.521&url=https%3A%2F%2Fdoi.org%2F10.2336%2Fnishinihonhifu.84.521&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif
顔面や四肢に広く皮下硬結を呈し眼症状を伴ったSubcutaneous Sarcoidosisの1例

池田賢太, 梶田藍, 野田拓志

日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集 52回 207 - 207 2022.12

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当院で経験したリンパ腫様丘疹症11例の臨床的検討

廣瀬梓, 平井陽至, 三宅智子, 梶田藍, 山崎修, 森実真

西日本皮膚科 84 ( 3 ) 2022

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乾癬の経過中に発症した落葉状天疱瘡の1例

芦田日美野, 前琴絵, 赤松由規, 徳田真優, 三宅智子, 梶田藍, 山崎修, 森実真

日本皮膚科学会雑誌 131 ( 11 ) 2451 - 2451 2021.10

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膿疱化・紅皮症化をきたし急性呼吸窮迫症候群を併発した尋常性乾癬の1例

芦田日美野, 前琴絵, 横山恵美, 梶田藍, 浦上仁志, 森実真, 谷口暁彦, 大野貴司

日本皮膚科学会雑誌 131 ( 11 ) 2445 - 2445 2021.10

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診断に難渋し、PET-CTにて低悪性度リンパ腫と診断された1例

廣瀬梓, 岡崎布佐子, 梶田藍

日本皮膚科学会雑誌 129 ( 11 ) 2345 - 2346 2019.10

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右鼠径部皮下に生じたsolitary fibrous tumorの1例

梶田藍, 川上佳夫, 新谷大悟, 小田和歌子

日本皮膚科学会雑誌 127 ( 11 ) 2498 - 2498 2017.10

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熱傷瘢痕部に有棘細胞癌を合併したNRAS遺伝子変異陽性の悪性黒色腫

山下珠代, 高須賀琴美, 丸田悠加, 梶田藍, 山崎修, 岩月啓氏, 鈴木規弘, 塩路康信

日本皮膚科学会雑誌 127 ( 9 ) 2143 - 2143 2017.8

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免疫チェックポイント阻害剤から緩和治療へ移行した進行期悪性黒色腫8例の検討

梶田藍, 山崎修, 加持達弥, 梅村啓史, 岩月啓氏

西日本皮膚科 79 ( 3 ) 305 - 305 2017.6

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IVIGにより血小板減少をきたした難治性尋常性天疱瘡の1例

浜重純平, 野村隼人, 禅正和真, 河野淳子, 難波裕子, 梶田藍, 平井陽至, 岩月啓氏, 松三友子

日本皮膚科学会雑誌 126 ( 11 ) 2135 - 2136 2016.10

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色素性乾皮症に生じた頭頂部悪性黒色腫

梶田藍, 河野淳子, 難波裕子, 平井陽至, 加持達弥, 山崎修, 岩月啓氏

日本皮膚科学会雑誌 126 ( 8 ) 1482 - 1482 2016.7

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大腿に発生したintraepithelial sebaceous carcinoma

梶田藍, 河野淳子, 難波裕子, 平井陽至, 加持達弥, 山崎修, 岩月啓氏, 谷口恒平, 柳井広之

日本皮膚科学会雑誌 126 ( 3 ) 322 - 323 2016.3

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外傷が契機と思われるnecrobiosis lipoidica

梶田藍, 山崎修, 岩月啓氏, 松浦能子

日本皮膚科学会雑誌 125 ( 11 ) 2093 - 2093 2015.10

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Interferon-gamma enhances TLR3 expression and anti-viral activity in keratinocytes

S. Morizane, A. Kajita, T. Takiguchi, T. Yamamoto, M. Yamada, K. Iwatsuki

JOURNAL OF INVESTIGATIVE DERMATOLOGY 135 ( 8 ) S95 - S95 2015.5

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DOI： 10.1038/jid.2015.125

Web of Science

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Th2サイトカインはアトピー性皮膚炎患者におけるカリクレイン7の発現と機能を増強する

森実真, 山崎研志, 梶田藍, 池田佳寿子, Zhan Maosheng, 青山裕美, Gallo Richard L., 岩月啓氏

岡山医学会雑誌 125 ( 3 ) 217 - 220 2013.12

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アトピー性皮膚炎の表皮角化細胞における組織カリクレイン7の発現

森実真, 山崎研志, 瀧口徹也, 池田佳寿子, 梶田藍, 青山裕美, 岩月啓氏

西日本皮膚科 74 ( 2 ) 215 - 215 2012.4

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Trichophyton tonsuransによるケルスス禿瘡の1例

林晴子, 梶田藍, 深松紘子, 山本剛伸, 三浦由宏

日本皮膚科学会雑誌 121 ( 11 ) 2283 - 2283 2011.10

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SLEに発症した網膜症(綿花様白斑)と疾患活動性との比較検討

杉生真帆, 梶田藍, 竹島千夏, 濱田利久, 青山裕美, 岩月啓氏, 松尾俊彦, 赤塚俊文

日本皮膚科学会雑誌 121 ( 11 ) 2278 - 2278 2011.10

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下眼瞼の腫瘤を形成し、顔面に丘疹が出没する菌状息肉症

梶田藍, 山崎修, 西原修美, 朝倉昇司

日本皮膚科学会雑誌 121 ( 10 ) 2074 - 2074 2011.9

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間質性肺炎が先行するANCA関連血管炎について

梶田藍, 濱田利久, 岩月啓氏, 谷本安, 矢野隆介, 金森達也

日本皮膚科学会雑誌 121 ( 10 ) 2080 - 2080 2011.9

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非結核性抗酸菌による難治性潰瘍の3例

大野貴司, 井形華絵, 梶田藍, 大塚正樹, 濱田利久, 岩月啓氏, 野村知代, 片山治子, 中永和枝, 石井則久

日本皮膚科学会雑誌 121 ( 10 ) 2078 - 2078 2011.9

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当院で施行した悪性黒色腫に対するセンチネルリンパ節生検結果についての考察遺伝子診断結果を中心に

鈴木規弘, 梶田藍, 安井陽子, 多田光太郎, 大塚正樹, 山崎修, 浅越健治, 田中了

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 27回 149 - 149 2011.6

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アトピー性皮膚炎における角化細胞産生カリクレイン7の発現制御機構

森実真, 梶田藍, 山崎研志, 岩月啓氏

Journal of Environmental Dermatology and Cutaneous Allergology 4 ( 5 ) 437 - 437 2010.11

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UVA、可視光線により膨疹の誘発を確認した日光蕁麻疹

竹島千夏, 濱田利久, 梶田藍, 大野貴司, 岩月啓氏, 青地聖子

Journal of Environmental Dermatology and Cutaneous Allergology 3 ( 4 ) 320 - 320 2009.10

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下眼瞼に腫瘤を形成し、顔面に丘疹が出没した菌状息肉症

梶田藍, 山崎修, 朝倉昇司, 山鳥一郎, 市村浩一, 吉野正

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 25回 181 - 181 2009.5

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サイトメガロウイルス感染を契機に血球貪食症候群、多臓器不全を呈した難治性成人発症Still病の一例

梶田藍, 北川正史, 竹山貴久, 赤木滋, 大石徹也

岡山医療センター年報 4 207 - 208 2008.12

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41歳女。患者は全身の皮疹、関節痛、高熱、咽頭痛を主訴とした。脾腫および肝機能異常、高フェリチン血症が認められ、成人発症Still病と診断された。治療としてプレドニゾロン(PSL)内服が開始されたが熱型の改善は得られなかった。そこで、メチルPSLパルス療法を施行、症状の活動性を抑えることができたものの、PSL増量しても症状が抑えきれなくなった。以後、2回目のパルス療法施行直後から発熱に加えて咽頭痛、頸部リンパ節腫脹、嘔吐、下痢、更に循環器不全、凝固異常、肝障害、腎障害、および肺野にスリガラス陰影が認められた。播種性血管内凝固の状態と考え、ICU管理とし、精査を施行したところ、サイトメガロウイルス感染、真菌感染、血球貪食症候群、無顆粒球症を合併した多臓器不全の状態であった。抗ウイルス薬、抗真菌薬、抗生剤、ステロイド、γ-グロブリンの投与、あわせて血液濾過透析、輸血、血漿交換を施行した結果、無顆粒球症は改善したが、全身状態の改善は認められず、患者は第66病日目に死亡となった。

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Presentations

外陰部病変を伴ったクローン病の1例

梶田藍

第153回日本皮膚科学会広島地方会 2023.9.2

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Event date： 2023.9.2 - 2023.9.3

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右鼠径部に生じたsolitary fibrous tumorの1例

梶田藍

第272回日本皮膚科学会岡山地方会 2017.9.3

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Event date： 2017.9.3

Language：Japanese Presentation type：Oral presentation (general)

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免疫チェックポイント阻害剤から緩和治療へ移行した進行期悪性黒色腫8例の検討

梶田藍

第68回日本皮膚科学会西部支部学術大会 2016.11.19

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Event date： 2016.11.19 - 2016.11.20

Language：Japanese Presentation type：Oral presentation (general)

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色素性乾皮症に生じた頭頂部悪性黒色腫

梶田藍

第268回日本皮膚科学会岡山地方会 2016.4.24

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Event date： 2016.4.24

Language：Japanese Presentation type：Oral presentation (general)

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大腿に発生したintraepithelial sebacious carcinoma

梶田藍

第267回日本皮膚科学会岡山地方会 2016.1.16

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Event date： 2016.1.16

Language：Japanese Presentation type：Oral presentation (general)

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外傷が契機と思われるnecrobiosis lipoidica

梶田藍

第266回日本皮膚科学会岡山地方会 2015.9.6

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Event date： 2015.9.6

Language：Japanese Presentation type：Oral presentation (general)

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Interferon gamma enhances innate immune response of epidermis through TLR3 in keratinocytes

Ai Kajita

The 71st Society for Investigative Dermatology Annual Meeting 2011.5.6

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Event date： 2011.5

Language：English Presentation type：Poster presentation

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Awards

The Okayama Medical Assosication Prise

2015.6 Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes

Ai Tenta(Ai Kajit

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Research Projects

ウイルス性皮膚疾患に対する短鎖二本鎖RNAを用いた外用核酸医薬の開発

Grant number：25K11605 2025.04 - 2028.03

日本学術振興会科学研究費助成事業基盤研究(C)

梶田藍, 谷口陽祐, 森実真

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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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Development of an external medicine which targets Toll-like receptor 3 in keratinocytes

Grant number：20K17351 2020.04 - 2022.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists Grant-in-Aid for Early-Career Scientists

Kajita Ai

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Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

We have focused on the innate immunity mechanism of skin viral infection in keratinocytes. Especially poly(I:C) enhances anti-viral activity via Toll-like receptor 3 (TLR3).The aim of this project is the creation of new external medicine with short chain double-strands RNA which targets TLR3 in keratinocytes.
We have shown that anti-viral factor was induced by short chain RNA with small molecular weight. We are currently investigating the effect of short chain RNA on antiviral activity in keratinocytes.

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Class subject in charge

Dermatology （2025academic year） Third semester - 火6
Dermatology (Core Clinical Practice) （2025academic year） special - その他
Dermatology （2025academic year） special - その他
Elective Clinical Practice (Dermatology) （2025academic year） special - その他
Dermatology （2024academic year） Third semester - 火5
Dermatology (Core Clinical Practice) （2024academic year） special - その他
Dermatology （2024academic year） special - その他
Dermatology （2023academic year） Third semester - 火5
Dermatology (Core Clinical Practice) （2023academic year） special - その他
Dermatology （2023academic year） special - その他
Dermatology （2022academic year） Third semester - 火5
Dermatology (Core Clinical Practice) （2022academic year） special - その他
Dermatology （2022academic year） special - その他
Dermatology (Core Clinical Practice) （2021academic year） special - その他
Dermatology （2021academic year） special - その他

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