Faculty Profiles - ARIYOSHI Noritaka

Papers - ARIYOSHI Noritaka

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INDUCTION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE AND P-450-4A SUBFAMILY IN GUINEA-PIGS BY TREATMENT WITH COPLANAR PCB Reviewed

Y KOGA, M TSUDA, N ARIYOSHI, Y ISHII, H YAMADA, K OGURI, H YOSHIMURA, Y FUNAE

JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 39 ( 1 ) P23 - P23 1993.2

Induction of Bilirubin UDP-Glucuronyltransferase and P-450 4A Subfamily in Guinea Pigs Reviewed

Yoshiko Koga, Yoshihiko Funaec, Hidetoshi Yoshimura, Noritaka Ariyoshi, Yuji Ishii, Hideyuki Yamada, Kazuta Oguri, Minoru Tsuda

Eisei kagaku 39 ( 1 ) 1993

Inducing Ability of Co-planar PCBs toward Bilirubin UDP-glucuronyltransferase of Liver Microsomes : The Remarkable Difference between Guinea Pigs and Rats. Reviewed

Fukuoka Acta Medica 84 ( 5 ) 175 1993

METABOLISM OF 2,4,5,2',4',5'-HEXACHLOROBIPHENYL WITH LIVER-MICROSOMES OF PHENOBARBITAL-TREATED DOG - THE POSSIBLE FORMATION OF PCB 2,3-ARENE OXIDE INTERMEDIATE Reviewed

N ARIYOSHI, N KOGA, K OGURI, H YOSHIMURA

XENOBIOTICA 22 ( 11 ) 1275 - 1290 1992.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：TAYLOR & FRANCIS LTD

1. Metabolism of 2,4,5,2',4',5'-hexachlorobiphenyl (HCB) was investigated in vitro using liver microsomes of one male beagle dog after phenobarbital treatment.
2. Three major metabolites were isolated and identified as 3-hydroxy-2,4,5,2',4',5'-HCB, 2-hydroxy-4,5,2',4',5'-pentachlorobiphenyl (PenCB), and 2-hydroxy-3,4,5,2',4',5'-HCB, by comparison of g.l.c.-mass spectrometry and H-1-n.m.r. data with those of authentic samples.
3. 2-Hydroxy-3,4,5,2',4',5'-HCB was found as a metabolite of 2,4,5,2',4',5'-HCB for the first time using dog liver microsomes. Present results indicate that this metabolite and the dechlorinated PenCB are derived from a metabolic intermediate, namely, 2,3-epoxy-2,4,5,2',4',5'-HCB. 2,3-Epoxide formation is a new metabolic pathway of PCB.

DOI： 10.3109/00498259209053156

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PURIFICATION AND CHARACTERIZATION OF 2 FORMS OF 2,3,4,7,8-PENTACHLORODIBENZOFURAN INDUCIBLE CYTOCHROME-P-450 IN HAMSTER LIVER Reviewed

N KOGA, N ARIYOSHI, H NAKASHIMA, H YOSHIMURA

JOURNAL OF BIOCHEMISTRY 107 ( 6 ) 826 - 833 1990.6

Language：English Publisher：JAPAN BIOCHEMICAL SOC

Golden SyrianハムスターにPenCDF (0.5 mg/kg)を膜腔内1回投与し,投与後5日目に屠殺し肝ミクロゾームを調製した.1.0%コール酸で可溶化後,ω-aminooctyl-Sepharose 4B, DE-52およびHydroxylapatiteの各カラムにて精製し,電気泳動的に単一で分子量52kDaのhamster P-450H(比含量12.8 nmol/mg protein)と分子量50 kDaのhamster P-450L(比含量7.73 nmol/mg protein)の2種を得た.いずれのP-450もCO-還元差スペクトルの吸収極大を446 nmに示し,それぞれ混合(高スピン+低スピン)型と低スピン型であった.なおhamster P-450H標品はhamster P-450Lの約27倍ものPenCDFを含有していた(0.107 nmol/nmol of P-450).両P-450に対する抗体を用いて未処理およびPenCDF処理ハムスター肝ミクロゾーム中の両P-450を定量したところ,hamster P-450Hは未処理ミクロゾーム全P-450量の約15%を占めること,およびPenCDF処理ではhamster P-450Hが60%,hamster P-450Lが30%を占めることが判明し,いずれの分子種もPenCDF誘導性であることが明らかとなった

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