Faculty Profiles - NAKAMURA Keiichiro

Papers - NAKAMURA Keiichiro

Division display 101 - 120 of about 205 ／ All the affair displays >>

Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide

Hiroyuki Sugiuraa, Hisakazu Nishimori, Hirofumi Matsuoka, Keiichiro Nakamura, Keiko Fujii, Nobuharu Fujii, Ken-ichi Matsuoka, Yoshinobu Maeda

ACTA MEDICA OKAYAMA 75 ( 2 ) 219 - 224 2021.4

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor's treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.

Web of Science

researchmap

DNA mismatch repair deficiency and p53 abnormality are age-related events in mixed endometrial carcinoma with a clear cell component. International journal

Naoyuki Ida, Keiichiro Nakamura, Masayuki Saijo, Atsuko Nasu, Tadashi Yoshino, Hisashi Masuyama, Hiroyuki Yanai

Pathology, research and practice 220 153383 - 153383 2021.4

Language：English Publishing type：Research paper (scientific journal)

Mixed endometrial carcinoma (MEC) is defined as a tumor composed of two or more spatially distinct subtypes, at least one of which is serous or clear cell carcinoma. In this study, the clinicopathological features of 15 MEC cases containing a clear cell component (MEC-C) were investigated. The ages of patients ranged from 32 to 83 years (median, 61 years). The combinations of carcinoma components observed were endometrioid and clear cell in ten patients; endometrioid, clear cell and serous in three; and clear cell and serous in two. Immunohistochemically, nine had DNA mismatch repair (MMR) protein deficiency (MMR-d), nine had loss of ARID1A and three cases had aberrant p53 expression. MMR-d and loss of ARID1A showed a strong correlation. Only one case showed both MMR-d and aberrant p53 expression. The patients with MMR-d were younger than those without MMR-d (median; 58 years vs. 71 years). Loss of ARID1A also showed significant predilection for younger women than ARID1A intact cases. In conclusion, MMR-d was observed in 60 % of MEC-C, showed predilection for young women, and was associated with ARID1A loss. In contrast, non- MMR-d MEC-C occurred in elder women and some tumors may associate with TP53 mutation. These findings suggest that MEC-C develop via two different molecular mechanisms and they are age-related events.

DOI： 10.1016/j.prp.2021.153383

PubMed

researchmap

TC療法を受ける婦人科癌患者におけるSF36を活用したQOL調査

春間朋子, 岡本和浩, 松岡敬典, 依田尚之, 久保光太郎, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 280 2021.3

卵巣がんの破裂を契機に腹部コンパートメント症候群をきたした1症例

谷佳紀, 依田尚之, 岡本和浩, 松岡敬典, 久保光太郎, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 329 2021.3

Shear Wave Elastographyは子宮頸癌に対する放射線治療の効果予測に有用である

松岡敬典, 中村圭一郎, 岡本和浩, 依田尚之, 久保光太郎, 春間朋子, 小川千加子, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 312 2021.3

当院の子宮体癌に対する低侵襲手術の検討

久保光太郎, 依田尚之, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 401 2021.3

高エストロゲン血症を伴う卵巣偽粘液腫の一例

川口優里香, 小川千加子, 松岡敬典, 岡本和浩, 依田尚之, 春間朋子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 331 2021.3

当院の子宮頸癌IB2期の検討

依田尚之, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 308 2021.3

ヒト絨毛細胞の浸潤におけるPROKR2を介したEG-VEGFの役割(The role of EG-VEGF through PROKR2 in the invasion of human trophoblast cells)

Tani Kazumasa, Mitsui Takashi, Mishima Sakurako, Oohira Akiko, Maki Jota, Eto Eriko, Hayata Kei, Nakamura Keiichiro, Masuyama Hisashi

日本産科婦人科学会雑誌 73 ( 臨増 ) S - 161 2021.3

子宮頸癌サバイバーにおける治療後筋肉・脂肪量変化の検討

坂井裕樹, 中村圭一郎, 松岡敬典, 依田尚之, 原賀順子, 久保光太郎, 春間朋子, 小川千加子, 鎌田泰彦, 増山寿

日本婦人科腫瘍学会雑誌 39 ( 1 ) 348 - 348 2021.1

Trabectedinの血管外漏出により重篤な皮膚障害を生じた1例

依田尚之, 中村圭一郎, 松岡敬典, 原賀順子, 春間朋子, 小川千加子, 増山寿

日本婦人科腫瘍学会雑誌 39 ( 1 ) 372 - 372 2021.1

放射線治療患者におけるShear Wave Elastography超音波を用いた腫瘍硬度の検討

松岡敬典, 中村圭一郎, 坂井裕樹, 依田尚之, 原賀順子, 久保光太郎, 春間朋子, 小川千加子, 鎌田泰彦, 増山寿

日本婦人科腫瘍学会雑誌 39 ( 1 ) 346 - 346 2021.1

子宮頸癌サバイバーにおける治療後筋肉・脂肪面積変化の検討

坂井裕樹, 中村圭一郎, 松岡敬典, 依田尚之, 原賀順子, 久保光太郎, 春間朋子, 小川千加子, 増山寿

現代産婦人科 69 ( 1 ) 11 - 17 2020.12

Language：Japanese Publisher：中国四国産科婦人科学会

癌治療の発展によりがんサバイバーが増え、治療後の生活の質がますます重要になっている。そこで今回、子宮頸癌治療後における経時的な身体的変化を着目し、検討した。当科で広汎性子宮全摘術及び同時化学放射線治療(concurrent chemoradiotherapy:CCRT)を行った子宮頸癌患者27名を対象とし、治療前後(治療前、治療直後、治療後1年、治療後3年、治療後5年)のCT画像を用いて、第三腰椎レベルの骨格筋面積(skeletal muscle index:SMI)、腸腰筋面積(iliopsoas muscle index:IMI)、皮下脂肪面積(subcutaneous fat mass index:SFMI)、内臓脂肪面積(visceral fat mass index:VFMI)を計測し、経時的変化を検討した。治療前平均SMI、IMI、SFMI、VFMIは35.56±3.61、3.67±0.76、51.56±19.76、34.88±17.89cm2/m2であった。治療後、筋肉・脂肪面積が20%以上減少した症例は治療直後ではIMI 3例(11.1%)、SFMI 4例(14.8%)、VFMI 12例(44.4%)、治療後1年IMI 2例(7.4%)、SFMI 9例(33.3%)、VFMI 11例(40.7%)、治療後3年IMI 3例(11.1%)、SFMI 3例(11.1%)、VFMI 7例(25.9%)、治療後5年IMI 6例(22.2%)、SFMI 6例(22.2%)、VFMI 8例(29.6%)であった。治療後における筋肉・脂肪面積変化は下肢リンパ浮腫や消化管・排尿障害の有害事象と関連はなく、治療後生活向上に向け、さらなる身体・精神面の解明が必要である。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J05038&link_issn=&doc_id=20201214470003&doc_link_id=%2Fcv0mtrob%2F2020%2F006901%2F003%2F0011-0017%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcv0mtrob%2F2020%2F006901%2F003%2F0011-0017%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

当院の早期子宮体がんにおける低侵襲手術の現況

依田尚之, 久保光太郎, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 36 ( Suppl.I ) [O - 464] 2020.11

当院における子宮体癌に対する低侵襲手術の変遷

久保光太郎, 楠元理恵, 依田尚之, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 36 ( Suppl.I ) [O - 410] 2020.11

CVポート部より漏出したトラベクテジンによる広範囲壊死の2例

杉原悟, 池田賢太, 山崎修, 下江敬生, 中村圭一郎, 森実真

日本皮膚外科学会誌 24 ( 2 ) 58 - 58 2020.10

当院でのロボット支援下子宮体癌手術の現況

中村圭一郎, 久保光太郎, 原賀順子, 松原侑子, 松岡敬典, 小川千加子, 増山寿

産婦人科手術 ( 31 ) 196 - 196 2020.8

Molecular Characterization of Second Primary Endometrial Cancer. International journal

Junko Haraga, Keiichiro Nakamura, Tomoko Haruma, Akihiro Nyuya, Takeshi Nagasaka, Hisashi Masuyama

Anticancer research 40 ( 7 ) 3811 - 3818 2020.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS AND METHODS: We enrolled 294 FPEC patients and 32 SPEC patients who had undergone surgical resection with curative intent. EC was divided into four groups according to Cancer Genome Atlas Research Network (TCGA) classification. RESULTS: SPEC patients having greater than a 10-year interval from prior malignancy had risk factors including type II histology, deeper myometrial invasion, cervical invasion, and copy number high (CNH) phenotype compared with patients having less than a 10-year interval (p=0.007, p=0.002, p=0.015 and p=0.001). CONCLUSION: SPEC patients having greater than a 10-year interval from prior malignancy possessed numerous high-risk factors for EC.

DOI： 10.21873/anticanres.14370

PubMed

researchmap

Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan

Mamiko Onuki, Koji Matsumoto, Takashi Iwata, Kasumi Yamamoto, Yoichi Aoki, Shoji Maenohara, Naotake Tsuda, Shoji Kamiura, Kazuhiro Takehara, Koji Horie, Nobutaka Tasaka, Hideaki Yahata, Yuji Takei, Hisamori Kato, Takeshi Motohara, Keiichiro Nakamura, Mitsuya Ishikawa, Tatsuya Kato, Hiroyuki Yoshida, Noriomi Matsumura, Hidekatsu Nakai, Shogo Shigeta, Fumiaki Takahashi, Kiichiro Noda, Nobuo Yaegashi, Hiroyuki Yoshikawa

CANCER SCIENCE 111 ( 7 ) 2546 - 2557 2020.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) data from 5045 Japanese women aged less than 40 years and diagnosed with cervical abnormalities at 21 hospitals during 2012-2017. These included cervical intraepithelial neoplasia grade 1 (CIN1, n = 573), CIN2-3 (n = 3219), adenocarcinoma in situ (AIS, n = 123), and invasive cervical cancer (ICC, n = 1130). The Roche Linear Array was used for HPV genotyping. The HPV type-specific relative contributions (RCs) were estimated by adding multiple infections to single types in accordance with proportional weighting attributions. Based on the comparison of type-specific RCs between CIN1 and CIN2-3/AIS/ICC (CIN2+), RC ratios were calculated to estimate type-specific risks for progression to CIN2+. Human papillomavirus DNA was detected in 85.5% of CIN1, 95.7% of CIN2-3/AIS, and 91.2% of ICC. Multiple infections decreased with disease severity: 42.9% in CIN1, 40.4% in CIN2-3/AIS, and 23.7% in ICC (P < .0001). The relative risk for progression to CIN2+ was highest for HPV16 (RC ratio 3.78, 95% confidence interval [CI] 3.01-4.98), followed by HPV31 (2.51, 1.54-5.24), HPV18 (2.43, 1.59-4.32), HPV35 (1.56, 0.43-8.36), HPV33 (1.01, 0.49-3.31), HPV52 (0.99, 0.76-1.33), and HPV58 (0.97, 0.75-1.32). The relative risk of disease progression was 1.87 (95% CI, 1.71-2.05) for HPV16/18/31/33/35/45/52/58, but only 0.17 (95% CI, 0.14-0.22) for HPV39/51/56/59/66/68. Human papillomavirus 16/18/31/33/45/52/58/6/11 included in a 9-valent vaccine contributed to 89.7% (95% CI, 88.7-90.7) of CIN2-3/AIS and 93.8% (95% CI, 92.4-95.3) of ICC. In conclusion, our data support the Japanese guidelines that recommend discriminating HPV16/18/31/33/35/45/52/58 genotypes for CIN management. The 9-valent vaccine is estimated to provide over 90% protection against ICC in young Japanese women.

DOI： 10.1111/cas.14445

Web of Science

researchmap

Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan. International journal

Mamiko Onuki, Koji Matsumoto, Takashi Iwata, Kasumi Yamamoto, Yoichi Aoki, Shoji Maenohara, Naotake Tsuda, Shoji Kamiura, Kazuhiro Takehara, Koji Horie, Nobutaka Tasaka, Hideaki Yahata, Yuji Takei, Yoichi Aoki, Hisamori Kato, Takeshi Motohara, Keiichiro Nakamura, Mitsuya Ishikawa, Tatsuya Kato, Hiroyuki Yoshida, Noriomi Matsumura, Hidekatsu Nakai, Shogo Shigeta, Fumiaki Takahashi, Kiichiro Noda, Nobuo Yaegashi, Hiroyuki Yoshikawa

Cancer science 111 ( 7 ) 2546 - 2557 2020.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/cas.14445

PubMed

researchmap

　 PREV - NEXT 　

< NAKAMURA Keiichiro >

Papers - NAKAMURA Keiichiro