Faculty Profiles - NAKAMURA Keiichiro

Papers - NAKAMURA Keiichiro

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MSI-Highを有する再発子宮体癌に対してペムブロリズマブを使用し、髄膜脳炎を発症した一例

長谷井稜子, 松岡敬典, 入江恭平, 岡本和浩, 依田尚之, 小川千加子, 中村圭一郎, 増山寿

現代産婦人科 69 ( Suppl. ) S54 - S54 2021.9

直腸壁全層に及ぶ腸管子宮内膜症に対し、TaTME(経肛門的全直腸間膜切除術)を併用し腹腔鏡下に根治術を施行した一例

岡本和浩, 鎌田泰彦, 許春花, 樫野千明, 松岡敬典, 依田尚之, 光井崇, 久保光太郎, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 37 ( Suppl.I ) 281 - 281 2021.9

当院での遺伝性乳癌卵巣癌症候群(HBOC)に対するリスク低減卵管卵巣摘出術(RRSO)の現状

久保光太郎, 入江恭平, 岡本和浩, 松岡敬典, 依田尚之, 小川千加子, 鎌田泰彦, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 37 ( Suppl.I ) 337 - 337 2021.9

当院の診断的腹腔鏡下手術の現状

依田尚之, 中村圭一郎, 入江恭平, 岡本和浩, 松岡敬典, 久保光太郎, 小川千加子, 増山寿

日本産科婦人科内視鏡学会雑誌 37 ( Suppl.I ) 338 - 338 2021.9

The Spiral Trial: A multicenter, randomized, controlled trial of Spiral thread sutures versus conventional thread sutures to prevent thinning of uterine scars following elective cesarean section. International journal

Jota Maki, Hikari Nakatou, Kazumasa Tani, Eriko Eto, Kei Hayata, Dan Yamamoto, Kenji Kai, Takashi Tamada, Kazuyo Akamatsu, Kunihiro Kawanishi, Keiichiro Nakamura, Hisashi Masuyama

Contemporary clinical trials 107 106449 - 106449 2021.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The aim of this randomized controlled trial (RCT) is to investigate whether Spiral-thread sutures are superior to conventional sutures (0-Vicryl) for preventing uterine scar thinning following elective cesarean section. METHODS: This multicenter, parallel-group RCT will be conducted in four hospitals across three medical regions in Japan to assess 200 women (≥20 years old) with singleton pregnancies who are scheduled to undergo cesarean sections. Eligible women will be randomly assigned (1:1 ratio) to receive either the conventional uterine suture continuous absorption thread, which is most commonly used in Japan, or the Spiral thread. The primary endpoint is the degree of scar thinning, measured by transvaginal ultrasonography 6-7 months postoperatively, to evaluate the position of the uterus (anterior or posterior tilt) and myometrial wound thickness. The degree of thinning will be compared between the groups, and four measurements (mm) of the thinning area, including caudal distance, depth of the depression, remaining thickness of the myometrium on the serous side of the most depressed area, and width of the depression, will be recorded in the sagittal view on transvaginal ultrasound. Secondary endpoints will include total operative time, suture application time (from birth to the end of uterine suturing), operative blood loss, number of additional Z-sutures or continuous sutures required to stop bleeding, maternal abnormality frequency (surgical complications and postoperative infections), surgeon's years of experience, and clinical interpretation of individual subscale scores. DISCUSSION: This study shall provide important evidence on the optimal suture for preventing hysterotomy wound thinning after the first cesarean section. TRIAL REGISTRATION: National Institute of Public Health, Japan: jRCT1062200001 (May 7, 2020; https://rctportal.niph.go.jp/en/detail?trial_id=jRCT1062200001) and Okayama University Certified Review Board: CRB6180001 (April 9, 2020, version 3.0).

DOI： 10.1016/j.cct.2021.106449

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ヒト絨毛細胞の浸潤におけるPROKR2を介したEG-VEGFの役割(The role of EG-VEGF through PROKR2 in the invasion of human trophoblast cells)

Tani Kazumasa, Mitsui Takashi, Mishima Sakurako, Oohira Akiko, Maki Jota, Eto Eriko, Hayata Kei, Nakamura Keiichiro, Masuyama Hisashi

The Journal of Obstetrics and Gynaecology Research 47 ( 8 ) 2829 - 2829 2021.8

卵巣癌易罹患性に関する遺伝学的背景を持つ卵巣子宮内膜症性嚢胞から癌化をきたした2症例

小川千加子, 依田尚之, 松岡敬典, 入江恭平, 岡本和浩, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 245 - 245 2021.7

当科における子宮頸癌に対するがんパネル検査の現況

松岡敬典, 小川千加子, 岡本和浩, 依田尚之, 久保光太郎, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 337 - 337 2021.7

Docetaxel and carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix: a phase II study.

Muneaki Shimada, Shinya Sato, Tadahiro Shoji, Shoji Nagao, Hideki Tokunaga, Kotaro Sueoka, Kazuhiro Takehara, Keiichiro Nakamura, Satoshi Yamaguchi, Junzo Kigawa

International journal of clinical oncology 26 ( 7 ) 1314 - 1321 2021.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: This phase II study evaluated the efficacy and safety of docetaxel/carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix. METHODS: A total of 50 patients with International Federation of Gynecology and Obstetrics stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix were enrolled and administered docetaxel at a dose of 60 mg/m2, followed by carboplatin at a dose based on the area under the receiver operating characteristic curve of 6. The treatments were repeated every 21 days until disease progression or unacceptable adverse events. Except for two patients, 48 were eligible for evaluation. Another patient withdrew consent before treatment; adverse events were evaluated in 47. RESULTS: The response rate was 47.9% with 5 patients achieving complete response, 18 partial response, 14 stable disease, and 6 progressive disease. The disease control rate was 77.1%. With a median follow-up duration of 368 days, the median progression-free survival and overall survival were 6.1 months (95% CI 5.5-8.6) and 15.8 months (95% CI 18.2-28.3), respectively. The most frequent grade 3 and grade 4 hematological toxicity was neutropenia, with 38 patients (81%) having grade 4 and 4 (9%) having grade 3 neutropenia. The non-hematological toxicities were mainly grade 1 or 2 in severity. CONCLUSION: Docetaxel/carboplatin chemotherapy was effective, with a higher disease control rate and well-tolerated chemotherapeutic regimen for patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix.

DOI： 10.1007/s10147-021-01903-1

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Docetaxel and carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix: a phase II study

Muneaki Shimada, Shinya Sato, Tadahiro Shoji, Shoji Nagao, Hideki Tokunaga, Kotaro Sueoka, Kazuhiro Takehara, Keiichiro Nakamura, Satoshi Yamaguchi, Junzo Kigawa

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 26 ( 7 ) 1314 - 1321 2021.7

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER JAPAN KK

Background This phase II study evaluated the efficacy and safety of docetaxel/carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix. Methods A total of 50 patients with International Federation of Gynecology and Obstetrics stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix were enrolled and administered docetaxel at a dose of 60 mg/m(2), followed by carboplatin at a dose based on the area under the receiver operating characteristic curve of 6. The treatments were repeated every 21 days until disease progression or unacceptable adverse events. Except for two patients, 48 were eligible for evaluation. Another patient withdrew consent before treatment; adverse events were evaluated in 47. Results The response rate was 47.9% with 5 patients achieving complete response, 18 partial response, 14 stable disease, and 6 progressive disease. The disease control rate was 77.1%. With a median follow-up duration of 368 days, the median progression-free survival and overall survival were 6.1 months (95% CI 5.5-8.6) and 15.8 months (95% CI 18.2-28.3), respectively. The most frequent grade 3 and grade 4 hematological toxicity was neutropenia, with 38 patients (81%) having grade 4 and 4 (9%) having grade 3 neutropenia. The non-hematological toxicities were mainly grade 1 or 2 in severity. Conclusion Docetaxel/carboplatin chemotherapy was effective, with a higher disease control rate and well-tolerated chemotherapeutic regimen for patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix.

DOI： 10.1007/s10147-021-01903-1

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当院で施行した卵巣がんのがんゲノム医療の現況

依田尚之, 小川千加子, 岡本和浩, 松岡敬典, 久保光太郎, 春間朋子, 中村圭一郎, 増山寿, 平沢晃

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 209 - 209 2021.7

当院における子宮体がんの遺伝子パネル検査の検討

岡本和浩, 小川千加子, 松岡敬典, 依田尚之, 久保光太郎, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 214 - 214 2021.7

卵巣癌易罹患性に関する遺伝学的背景を持つ卵巣子宮内膜症性嚢胞から癌化をきたした2症例

小川千加子, 依田尚之, 松岡敬典, 入江恭平, 岡本和浩, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 245 - 245 2021.7

当科における子宮頸癌に対するがんパネル検査の現況

松岡敬典, 小川千加子, 岡本和浩, 依田尚之, 久保光太郎, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 337 - 337 2021.7

当院で施行した卵巣がんのがんゲノム医療の現況

依田尚之, 小川千加子, 岡本和浩, 松岡敬典, 久保光太郎, 春間朋子, 中村圭一郎, 増山寿, 平沢晃

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 209 - 209 2021.7

当院における子宮体がんの遺伝子パネル検査の検討

岡本和浩, 小川千加子, 松岡敬典, 依田尚之, 久保光太郎, 春間朋子, 中村圭一郎, 平沢晃, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 214 - 214 2021.7

当院で施行したリスク低減卵管卵巣摘出術(RRSO)症例の検討

入江恭平, 小川千加子, 岡本和浩, 松岡敬典, 依田尚之, 久保光太郎, 春間朋子, 中村圭一郎, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 259 - 259 2021.7

高齢者婦人科癌患者のCharlson Comorbidity Indexは予後予測因子になる

中村圭一郎, 入江恭平, 岡本和浩, 松岡敬典, 依田尚之, 久保光太郎, 春間朋子, 小川千加子, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 350 - 350 2021.7

当科における卵巣明細胞癌の検討

春間朋子, 岡本和浩, 松岡敬典, 依田尚之, 久保光太郎, 小川千加子, 中村圭一郎, 増山寿

日本婦人科腫瘍学会学術講演会プログラム・抄録集 63回 263 - 263 2021.7

Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide.

Hiroyuki Sugiura, Hisakazu Nishimori, Hirofumi Matsuoka, Keiichiro Nakamura, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Yoshinobu Maeda

Acta medica Okayama 75 ( 2 ) 219 - 224 2021.4

Language：English

Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor's treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.

DOI： 10.18926/AMO/61904

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Papers - NAKAMURA Keiichiro