Faculty Profiles - FUJII Yasuhiro

MISC - FUJII Yasuhiro

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左心低形成症候群に対する心臓内幹細胞自家移植療法第I相臨床試験18ヵ月長期成績

石神修大, 樽井俊, 逢坂大樹, 後藤拓弥, 奥山倫弘, 小林純子, 藤井泰宏, 黒子洋介, 川畑拓也, 小谷恭弘, 吉積功, 新井禎彦, 笠原真悟, 佐野俊二, 王英正

日本心臓血管外科学会雑誌 44 ( Suppl. ) 185 - 185 2015.1

外腸骨動脈仮性動脈瘤-回腸導管瘻に対してF-Fバイパス術及び右総腸骨、内外腸骨コイル塞栓術を施行した一例

河田達志, 平田武志, 高本篤, 小林泰之, 佐々木克己, 荒木元朗, 江原伸, 渡邉豊彦, 那須保友, 公文裕巳, 藤井泰宏, 大澤晋, 藤原寛康

西日本泌尿器科 76 ( 増刊 ) 129 - 129 2014.10

高度進行性強皮症に対し自家静脈内シャントを行った一症例

藤井泰宏, 大澤晋, 黒子洋介, 川畑拓也, 増田善逸, 小谷恭弘, 吉積功, 新井禎彦, 笠原真悟, 堀尾直裕, 後藤拓哉, 田邊克幸, 佐野俊二

脈管学 54 ( Suppl. ) S223 - S223 2014.10

PADに対するハイブリッド治療循環器内科と血管外科の共生を目指して

大澤晋, 戸田洋伸, 藤井泰宏, 伊藤浩, 佐野俊二

脈管学 54 ( Suppl. ) S188 - S188 2014.10

子羊を用いた単心室VADサポートモデルにおける、小型Axial Pumpの優位性:HeartMate X v.s. Berlin Heart Excor

藤井泰宏

人工臓器 43 ( 2 ) S - 124 2014.9

エプシュタイン病の病態と治療新生児～乳児期早期に外科治療を要する重症エブスタイン奇形の治療戦略(どこまでFontan循環を回避できるのか?)

藤井泰宏, 新井禎彦, 笠原真悟, 小谷恭弘, 川畑拓也, 黒子洋介, 吉積功, 佐野俊二

日本小児循環器学会雑誌 30 ( Suppl. ) s158 - s158 2014.6

胎児診断に基く周産期治療体外循環を使用した胎児心臓手術開発の現状と可能性

藤井泰宏

日本小児循環器学会雑誌 30 ( Suppl. ) s154 - s154 2014.6

Effects of atrial natriuretic peptide after prolonged hypothermic storage of the isolated rat heart. International journal

Hitoshi Kanamitsu, Yasuhiro Fujii, Hideya Mitsui, Shunji Sano

Artificial organs 37 ( 11 ) 1003 - 8 2013.11

Language：English Publisher：WILEY-BLACKWELL

Primary graft failure (PGF) caused by ischemia-reperfusion injury (IRI) is the strongest determinant of perioperative mortality after heart transplantation. Atrial natriuretic peptide (ANP) has been found to reduce the IRI of cardiomyocytes and may be beneficial in alleviating PGF after heart transplantation, although there is a lack of evidence to support this issue. The purpose of this study was to investigate the cardioprotective effects of ANP after prolonged hypothermic storage. For this purpose, an isolated working-heart rat model was used. After the preparation, the hearts were arrested with and stored in an extracellular-based cardioplegic solution at 3-4 degrees C for 6 h and followed by 25 min of reperfusion. The hearts were divided into four groups (n = 7 in each group) according to the timing of ANP administration: Group 1 (in perfusate before storage), Group 2 (in cardioplegia), Group 3 (in reperfusate), and control (no administration of ANP). Left ventricular functional recovery and the incidence of ventricular fibrillation (VF) were compared. ANP administration at the time of reperfusion improved the percent recovery of left ventricular developed pressure (control, 45.5 +/- 10.2; Group 1, 47.4 +/- 8.8; Group 2, 45.3 +/- 12 vs. Group 3, 76.3 +/- 7; P < 0.05) and maximum first derivative of the left ventricular pressure (control, 47.9 +/- 8.7; Group 1, 46.7 +/- 8.8; Group 2, 49.6 +/- 10.8 vs. Group 3, 76.6 +/- 7.5; P < 0.05). The incidence of VF after reperfusion did not differ significantly among these four groups (71.4, 85.7, 57.1, and 85.7% in Groups 1, 2, 3, and control, respectively). This result suggests that the administration of ANP at the time of reperfusion may have the potential to decrease the incidence of PGF after heart transplantation.

DOI： 10.1111/aor.12120

Web of Science

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One and one-half心室修復術の存在意義は? 中期成績からの考察

佐野俊二, 小林純子, 笠原真悟, 藤井泰宏, 立石篤史, 黒子洋介, 川畑拓也, 奥山倫弘, 吉積功, 新井禎彦, 大月審一

日本小児循環器学会雑誌 28 ( Suppl. ) s151 - s151 2012.6

PA/VSD、MAPCAsに対する外科治療の中期成績

新井禎彦, 藤井泰宏, 黒子洋介, 川畑拓也, 立石篤志, 吉積功, 笠原真悟, 佐野俊二

日本小児循環器学会雑誌 28 ( Suppl. ) s173 - s173 2012.6

Atrioventricular valve repair for patient with heterotaxy syndrome and a functional single ventricle. International journal

Shunji Sano, Yasuhiro Fujii, Sadahiko Arai, Shingo Kasahara, Atsushi Tateishi

Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual 15 ( 1 ) 88 - 95 2012

Language：English

Heterotaxy syndrome is a mortality risk factor for patients with complex heart disease. These patients often have common atrioventricular valve (CAVV) morphology and significant atrioventricular valve regurgitation - yet another mortality risk factor in congenital heart disease. Thus, patients with both heterotaxy syndrome and atrioventricular valve regurgitation are at highest risk of mortality. A large number of patients with heterotaxy syndrome have CAVV and a functional single ventricle. These patients are more difficult to operate than patients with biventricular morphology because in the former, the CAVV is often less adapted to systemic afterload than the mitral valve. Herein, we present the results of atrioventricular valve repair surgeries performed at the Okayama University Hospital on patients with heterotaxy syndrome, atrial isomerism, and a functional single ventricle. In addition, we review the current literature in this typically challenging patient population. In-depth understanding of reasonable management strategies and resolution of technical issues will help guide surgeons during this procedure. © 2012 Elsevier Inc..

DOI： 10.1053/j.pcsu.2012.01.014

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Ebstein 奇形の外科治療 Invited

137 - 139 2012

Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow: digital radiographic study in neonatal rats.

Tomoko Tomii, Osami Honjo, Takeshi Matsumoto, Hiroyuki Tachibana, Yasuhiro Fujii, Kozo Ishino, Yasuo Ogasawara, Shunji Sano

General thoracic and cardiovascular surgery 59 ( 10 ) 672 - 80 2011.10

Language：English

Purpose: This study sought to show the heterogeneity of myocardial blood flow in the chronically hypoxic infantile myocardium and its response to reoxygenation using a novel type of digital radiography. Methods: Newborn rats were housed in a hypoxic chamber or in a normal chamber (controls). After 4 or 8 weeks, the control rats were ventilated with normoxic conditions, and the rats housed under hypoxia were ventilated with either hypoxic (cyanotic group) or normoxic conditions (reoxygenation group). Desmethylimipramine labeled with tritium (HDMI) was injected into the left ventricle, and both ventricular free walls were sectioned and sliced from the subepicardium to the subendocardium at 10 mm thickness. The within-layer distribution of HDMI density was measured by digital radiography, and its spatial heterogeneity (i.e., flow heterogeneity) was quantified by the coefficient of variation (CV) of flows. Results: There were no differences in the CV between the groups in either ventricle at 4 weeks of age and no differences in the right ventricle at 8 weeks of age. There was a trend toward a higher left ventricular CV in the cyanotic group than in the control group at 8 weeks of age (0.637 ± 0.099 vs. 0.510 ± 0.060, P = 0.06). At 8 weeks of age, the CV was lower in both ventricles in the reoxygenation group than in those of the control and cyanotic groups. Conclusion: The chronically hypoxic infantile myocardium exhibits regional flow heterogeneity similar to that observed in the normal myocardium in both ventricles and exhibits reduced flow heterogeneity in response to reoxygenation. © 2011 The Japanese Association for Thoracic Surgery.

DOI： 10.1007/s11748-010-0685-9

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成人期まで無症状で経過した大動脈弓離断症の一手術例

堀尾直裕, 笠原真悟, 石神修大, 平田昌敬, 小林純子, 樽井俊, 桜井茂, 藤井泰宏, 鵜垣伸也, 川畑拓也, 立石篤史, 藤田康文, 高垣昌巳, 新井禎彦, 三井秀也, 佐野俊二

岡山医学会雑誌 123 ( 2 ) 170 - 170 2011.8

Double-barrel Damus-Kaye-Stansel吻合は、end-to-side Damus-Kaye-Stansel吻合に比べて肺動脈弁の予防に優れている肺動脈弁洞形態の保存の重要性(Double-barrel Damus-Kaye-Stansel operation is better than end-to-side Damus-Kaye-Stansel operation for preserving the pulmonary valve function : the importance of preserving the shape of the pulmonary sinus)

藤井泰宏

岡山医学会雑誌 123 ( 2 ) 172 - 172 2011.8