Faculty Profiles - TOYOOKA Shinichi

MISC - TOYOOKA Shinichi

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The impact of BAC components and epidermal growth factor receptor (EGFR) gene on the clinical outcomes in small adenocarcinoma of the lung

Naruyuki Kobayashi, Shinichi Toyooka, Kouichi Ichimura, Hiroyuki Yanai, Junichi Soh, Hiroki Otani, Masaru Jida, Hiromasa Yamamoto, Yoshifumi Sano, Katsuyuki Kiura, Hiroshi Date

CANCER RESEARCH 68 ( 9 ) 2008.5

DP-062-8 非小細胞肺癌におけるBRAF遺伝子変異(第108回日本外科学会定期学術集会)

重松久之, 鈴木実, 豊岡伸一, 山本寛斉, 藤澤武彦, 伊達洋至, Gazdar Adi

日本外科学会雑誌 109 ( 2 ) 469 - 469 2008.4

Advances in the molecular biology of malignant mesothelioma

Shinichi Toyooka, Takumi Kishimoto, Hiroshi Date

ACTA MEDICA OKAYAMA 62 ( 1 ) 1 - 7 2008.2

Language：English Publishing type：Book review, literature introduction, etc. Publisher：OKAYAMA UNIV MED SCHOOL

Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as a result of widespread exposure to asbestos. As for the molecular alterations that occur in MM, chromosome alterations including homo-deletion of the P16 and P14 genes located in the 9p21 are well known. Mutations are rare in the P53 and Ras genes, which are frequently present in epithelial solid tumors. However, mutations are frequently present in the neurofibromatosis type 2 gene. Epigenetic alterations including DNA methylation have been found in the MM, the profile of which is different from that of lung cancer, although differential diagnosis is sometimes clinically difficult. As in other malignant tumors, genes that are related to immortalization, proliferation, metastasis, angiogenesis, and anti-apoptosis are also overexpressed in MM, contributing to its malignant phenotype. It is of interest that simian virus 40 has been implicated to be one of the causative factors of MM in western, countries. Although the causative role of asbestos is well-known in MM, much less information is available for MM than for other malignant tumors regarding the molecular alterations that occur in the disease. In terms of future tasks, it will be necessary to apply the knowledge that is learned about molecular alterations to clinical practice and to further elucidate the pathogenesis of MM with extensive research.

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ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer

FUJII T

Lung Cancer 59 ( 3 ) 377 - 384 2008

Elevated serum level of sialylated glycoprotein KL-6 predicts a poor prognosis in patients with non-small cell lung cancer treated with gefitinib

Fujiwara Y, Kiura K, Toyooka S, Hotta K, Tabata M, Takigawa N, Soh J, Tanimoto Y, Kanehiro A, Kato K, Date H, Tanimoto M

Lung Cancer 59 ( 1 ) 81 - 87 2008

Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung

Soh J, Toyooka S, Ichihara S, Asano H, Kobayashi N, Suehisa H, Otani H, Yamamoto H, Ichimura K, Kiura K, Gazdar AF, Date H

J Thorac Oncol 3 ( 4 ) 340 - 347 2008

Detection of EGFR gene mutations using the wash fluid of CT-guided biopsy needle in NSCLC patients

Hiroki Otani, Shinichi Toyooka, Junichi Soh, Hiromasa Yamamoto, Hiroshi Suehisa, Naruyuki Kobayashi, Hideo Gobara, Hidefumi Mimura, Katsuyuki Kiura, Yoshifumi Sano, Susumu Kanazawa, Hiroshi Date

JOURNAL OF THORACIC ONCOLOGY 3 ( 5 ) 472 - 476 2008

Language：English Publisher：ELSEVIER SCIENCE INC

Introduction: In this study, we examined whether epidermal growth factor receptor (EGFR) mutations were detectable using a polymerase chain reaction-based assay and wash fluid of computed tomography (CT)-guided lung biopsy needles.Methods: DNA was extracted from wash fluid of CT-guided biopsy needles of 53 lung tumors (as diagnosed according to the results of the CT-guided biopsies). EGFR mutations, specifically exon19 deletions and exon21 L858R mutations, were examined using a mutant-enriched polymerase chain reaction assay. We also examined the presence of EGFR mutations in 26 surgically resected tumor specimens and compared the results with those obtained for the corresponding wash fluid samples.Results: The amount of DNA obtained for the wash fluid of the CT-guided biopsy needles ranged from 35 to 2360 ng. There were no significant differences in the amount of extracted DNA according to the tumor characteristics, including tumor size and the percentage of ground glass opacity. Thirty-four of the 53 lung tumor samples were histologically diagnosed as non-small cell lung cancer (NSCLC). Exon19 deletions and exon21 L858R mutations in EGFR were detected in 4 (12%) and 13 (38%) of 34 NSCLC cases, respectively. No EGFR mutations were found in the non-NSCLC cases. The EGFR mutation status in the wash fluid samples was consistent with those obtained for all 26 corresponding surgical specimens.Conclusion: Our results indicate that EGFR mutations can be detected using wash fluid of CT-guided biopsy needles. In this manner, the DNA genotype can be determined even in extremely small clinical specimens using highly sensitive assays.

DOI： 10.1097/JTO.0b013e31816de2cd

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Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer.

Suzuki H, Ouchida M, Yamamoto H, Yano M, Toyooka S, Aoe M, Shimizu N, Date H, Shimizu K

Lung Cancer 5 24 - 31 2008

O13-05 臨床心臓死肺移植における中間期成績(肺移植,第25回日本呼吸器外科学会総会)

大藤剛宏, グレッグスネル, 山根正修, 岡崎恵, 豊岡伸一, 佐野由文

日本呼吸器外科学会雑誌 22 ( 3 ) 432 - 432 2008

PIK3CA mutations and copy number gains in human lung cancers. 68, 6913-21, 2008. Reviewed

Yamamoto, H, Shigematsu, H, Nomura, M, Lockwood, W.W, Sato, M, Okumura, N, Soh, J, Suzuki, M, Wistuba, II, Fong, K.M, Lee, H, Toyooka, S, Date, H, Lam, W.L, Minna, J.D, Gazdar, A.F

Cancer Res 68 6913-21 2008

O14-01 腫瘍径20mm以下, stage IAの肺腺癌の予後におけるBAC componentおよびEGFR遺伝子変異の意義(肺癌4,第25回日本呼吸器外科学会総会)

小林成行, 佐野由文, 豊岡伸一, 市村浩一, 柳井広之, 宗淳一, 大谷弘樹, 治田賢, 山根正修, 大藤剛宏

日本呼吸器外科学会雑誌 22 ( 3 ) 432 - 432 2008

P37-10 p-T3非小細胞肺癌の予後因子に関する検討(肺癌・予後1,第25回日本呼吸器外科学会総会)

田尾裕之, 豊岡伸一, 小林成行, 山根正修, 大藤剛宏, 佐野由文

日本呼吸器外科学会雑誌 22 ( 3 ) 540 - 540 2008

Induction chemoradiotherapy prior to surgery for non-small cell lung cancer invading the left atrium

TOYOOKA S

Eur J Cardiothorac Surg 33 ( 2 ) 315 - 316 2008

原発性肺高血圧症例における生体肺移植後の心機能の検討

豊岡伸一, 草野研吾, 五藤恵次, 岡崎幹生, 山根正修, 大藤剛宏, 佐野由文, 福家総一郎, 岡崎恵, 大江透, 笠原真悟, 佐野俊二, 伊達洋至

General Thoracic and Cardiovascular Surgery 56 ( Supplement ) 2008

S1-1 ゲフィチニブ治療における臨床効果予測因子 : 非小細胞肺癌408例の検討(シンポジウム肺癌の分子生物学とその臨床応用,第48回日本肺癌学会総会号)

豊岡伸一, 高野利実, 高坂貴行, 堀田勝幸, 青江啓介, 木浦勝行, 大江裕一郎, 光冨徹哉, 伊達洋至

肺癌 47 ( 5 ) 2007.10

P-218 病理病期IA,腫瘍径20mm以下の非小細胞肺癌における再発危険因子・予後因子の検討(一般演題(ポスター)23 予後因子1,第48回日本肺癌学会総会号)

小林成行, 豊岡伸一, 市村浩一, 柳井広之, 山根正修, 大藤剛宏, 佐野由文, 伊達洋至

肺癌 47 ( 5 ) 2007.10

P-3 CTガイド下肺生検針洗浄液からのEGFR遺伝子変異の検出(一般演題(ポスター) トランスレーショナルリサーチ,第48回日本肺癌学会総会)

大谷弘樹, 豊岡伸一, 治田賢, 市原周治, 小林成行, 宗淳一, 末久弘, 山根正修, 大藤剛宏, 佐野由文, 伊達洋至

肺癌 47 ( 5 ) 2007.10

P-13 PDCD5遺伝子における遺伝子多型の検討(一般演題(ポスター) 分子生物学,第48回日本肺癌学会総会)

難波圭, 豊岡伸一, 宗淳一, 市原周治, 小林成行, 山根正修, 大藤剛宏, 佐野由文, 伊達洋至

肺癌 47 ( 5 ) 2007.10

WS7-3 CTガイド下肺生検は胸膜播種および癌性胸膜炎を惹起するか?(ワークショップ癌性胸膜炎と心膜炎,第48回日本肺癌学会総会号)

佐野由文, 田尾裕之, 山根正修, 豊岡伸一, 大藤剛宏, 金澤右, 伊達洋至

肺癌 47 ( 5 ) 2007.10

O-107 術前PET-CTでリンパ節転移陰性であった原発性肺癌におけるリンパ節転移の検討(一般演題(口演)19 画像診断,第48回日本肺癌学会総会号)

大谷真二, 豊岡伸一, 三好健太郎, 山本澄治, 久保孝文, 田尾裕之, 山根正修, 大藤剛宏, 佐野由文, 伊達洋至, 市村浩一

肺癌 47 ( 5 ) 2007.10

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