Faculty Profiles - TOYOOKA Shinichi

MISC - TOYOOKA Shinichi

Division display 441 - 460 of about 703 ／ All the affair displays >>

肺癌の肺内転移と鑑別を要した肺クリプトコッカス症の1例

諏澤憲, 杉本誠一郎, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

肺癌 52 ( 4 ) 453 - 454 2012.8

左下葉原発肺癌に対し,術前導入化学放射線療法後に左下葉・舌区スリーブ切除術を施行した1例

山本寛斉, 豊岡伸一, 宗淳一, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

肺癌 52 ( 4 ) 450 2012.8

General Thoracic Surgery and Perioperative Management in the Patients with Endocrine Dysfunction

65 ( 8 ) 720 - 723 2012.7

Updated overall survival results of WJTOG 3405, a randomized phase III trial comparing gefitinib (G) with cisplatin plus docetaxel (CD) as the first-line treatment for patients with non-small cell lung cancer harboring mutations of the epidermal growth factor receptor (EGFR)

Tetsuya Mitsudomi, Satoshi Morita, Yasushi Yatabe, Shunichi Negoro, Isamu Okamoto, Takashi Seto, Miyako Satouchi, Hirohito Tada, Tomonori Hirashima, Kazuhiro Asami, Nobuyuki Katakami, Minoru Takada, Hiroshige Yoshioka, Kazuhiko Shibata, Shinzoh Kudoh, Eiji Shimizu, Hiroshi Saito, Shinichi Toyooka, Kazuhiko Nakagawa, Masahiro Fukuoka

JOURNAL OF CLINICAL ONCOLOGY 30 ( 15 ) 2012.5

FOXP3+/CD8+tumor-infiltrating T-cell ratio as a marker for pathologic response to induction therapy of non-small cell lung cancer.

Hiroyuki Tao, Kazuhiko Shien, Junichi Soh, Fumiho Sano, Tatsuro Hayashi, Hiromasa Yamamoto, Toshiki Tanaka, Eisuke Matsuda, Shinichi Toyooka, Kazunori Okabe, Kazurou Sugi, Shinichiro Miyoshi

JOURNAL OF CLINICAL ONCOLOGY 30 ( 15 ) 2012.5

Knockdown of EGFR to investigate its therapeutic potential for treatment of non-small cell lung cancers

Junichi Soh, Kazuhiko Shien, Tsuyoshi Ueno, Kazunori Tsukuda, Kenichi Suda, Takafumi Kubo, Masashi Furukawa, Takayuki Muraoka, Yuho Maki, Norimitsu Tanaka, Hiromasa Yamamoto, Katsuyuki Kiura, Tetsuya Mitsudomi, Shinichi Toyooka, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

Aberrant NFKBIA expression in lung adenocarcinomas arising from never smokers

Masashi Furukawa, Junichi Soh, Shinichi Toyooka, Kazuhiko Shien, Yuho Maki, Takayuki Muraoka, Norimitsu Tanaka, Tsuyoshi Ueno, Hiroaki Asano, Kazunori Tsukuda, Masaomi Yamane, Takahiro Oto, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

Usefulness of sensitive digital PCR assay to quantify microRNA-34b/c methylation in the circulating serum DNA of malignant mesothelioma patients

Takayuki Muraoka, Junichi Soh, Shinichi Toyooka, Nobukazu Fujimoto, Keisuke Aoe, Hiromasa Yamamoto, Kazuhiko Shien, Masashi Furukawa, Yuho Maki, Norimitsu Tanaka, Tsuyoshi Ueno, Hiroaki Asano, Kazunori Tsukuda, Takumi Kishimoto, Takemi Otsuki, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

Mechanisms and overcome of acquired resistance to EGFR tyrosine kinase inhibitors

Junichi Soh, Shinichi Toyooka, Tsuyoshi Ueno, Shinichiro Miyoshi

Japanese Journal of Lung Cancer 52 ( 2 ) 131 - 135 2012.4

Language：Japanese Publishing type：Book review, literature introduction, etc.

Development of effective therapies for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, which account for approximately 40% of lung adenocarcinoma patients in Japan, is important to improve the clinical outcome of NSCLC. EGFR-mutant NSCLCs are sensitive to EGFR tyrosine kinase inhibitors (EGFR-TKIs), and elucidating the binding affinity of adenosine triphosphate (ATP) and EGFR-TKI to wild type or mutant EGFR helps our understanding of the mechanisms of resistance to EGFR-TKI. The mechanisms of acquired resistance to EGFR-TKIs are broadly classified into two categories: 1) secondly acquired EGFR mutations including T790M and 2) "oncogene kinase switch" such as MET gene amplification. To overcome the acquired resistance, it is essential to develop new drugs and therapeutic strategies. The heat shock protein 90 (Hsp90) inhibitors show anti-proliferative effect by inhibiting the stabilization of various client proteins such as mutant-EGFR, MET and AKT. The clinical trials of Hsp90 inhibitors are currently-conducted, which is expected to show the efficacy on NSCLC patients with any kind of acquired resistance for EGFR-TKIs. © 2012 The Japan Lung Cancer Society.

DOI： 10.2482/haigan.52.131

Scopus

researchmap

Prognostic impact of GLUT-1 and Ki-67 expressions in early-stage lung adenocarcinomas

Yuho Maki, Shinichi Toyooka, Koichi Ichimura, Junichi Soh, Kazuhiko Shien, Masashi Furukawa, Takayuki Muraoka, Norimitsu Tanaka, Tsuyoshi Ueno, Hiromasa Yamamoto, Hiroaki Asano, Kazunori Tsukuda, Masomi Yamane, Takahiro Oto, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

Down-regulation of microRNA34 induces cell proliferation and invasion of human mesothelial cells

Norimitsu Tanaka, Shinichi Toyooka, Junichi Soh, Kazunori Tsukuda, Kazuhiko Shien, Masashi Furukawa, Takayuki Muraoka, Yuho Maki, Tsuyoshi Ueno, Hiroaki Asano, Takemi Otsuki, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

Kazuhiko Shien, Shinichi Toyooka, Kouichi Ichimura, Junichi Soh, Masashi Furukawa, Yuho Maki, Takayuki Muraoka, Norimitsu Tanaka, Tsuyoshi Ueno, Hiroaki Asano, Kazunori Tsukuda, Hiromasa Yamamoto, Masaomi Yamane, Takahiro Oto, Katsuyuki Kiura, Shinichiro Miyoshi

CANCER RESEARCH 72 2012.4

RAS signaling pathway gene mutations and acquired resistance to EGFR tyrosine-kinase inhibitors in EGFR mutant lung cancer

Kadoaki Ohashi, Juliann Chmielecki, Ya-Lun Lin, Helen Pan, Cindy Vnencak-Jones, Maria Arcila, Lu Wang, Lynnette Fernandez, Aoe Keisuke, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka, Katsuyuki Kiura, Roman Thomas, James Chih-Hsin Yang, Vincent Miller, Marc Ladanyi, Katerina Politi, William Pao

CANCER RESEARCH 72 2012.4

530 Detection of Post Lung Transplant Airway Ischemia Using Autofluorescence Imaging (AFI) Bronchoscopy

I. Norichika, T. Oto, M. Okada, H. Masaaki, H. Nisikawa, K. Miyoshi, S. Otani, S. Sugimoto, M. Yamane, S. Toyooka, S. Miyoshi

The Journal of Heart and Lung Transplantation 31 ( 4 ) 2012.4

PS-109-6 REIC/Dickkopf-3 shows anti-proliferative effect for non-small cell lung cancer cells with negative phosphorylated-Akt status

Tanaka Norimitsu, Toyooka Shinichi, Watanabe Masami, Soh Junichi, Sakaguchi Masakiyo, Tsukuda Kazunori, Asano Hiroaki, Shien Kazuhiko, Furukawa Masashi, Maki Yuho, Muraoka Takayuki, Huh Nam-ho, Nasu Yasutomo, Kumon Hiromi, Miyoshi Shinichiro

Journal of Japan Surgical Society 113 ( 2 ) 710 - 710 2012.3

PD-9-4 局所進行非小細胞肺癌に対する術前放射線同時併用化学療法後の肺切除の成績と周術期管理の工夫(PD-9 パネルディスカッション(9)局所進行肺癌に対する外科治療戦略,第112回日本外科学会定期学術集会)

豊岡伸一, 宗淳一, 牧佑歩, 上野剛, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

日本外科学会雑誌 113 ( 2 ) 2012.3

PS-156-1 非小細胞肺癌に対する根治的放射線化学療法後手術の治療成績(肺集学的治療,ポスターセッション,第112回日本外科学会定期学術集会)

宗淳一, 豊岡伸一, 枝園和彦, 三好健太郎, 上野剛, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

日本外科学会雑誌 113 ( 2 ) 2012.3

PD-9-2 T3/4局所進行非小細胞肺癌に対する導入化学放射線治療後手術療法(PD-9 パネルディスカッション(9)局所進行肺癌に対する外科治療戦略,第112回日本外科学会定期学術集会)

枝園和彦, 豊岡伸一, 木浦勝行, 松尾恵太郎, 宗淳一, 山根正修, 大藤剛宏, 武本充広, 伊達洋至, 三好新一郎

日本外科学会雑誌 113 ( 2 ) 2012.3

術前導入化学放射線療法後,気管支形成を伴う右上葉切除,頚部・縦隔リンパ節郭清を施行した肺癌1例

鹿谷芳伸, 豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎, 武本充宏, 木浦勝行

肺癌 52 ( 1 ) 120 2012.2

術前放射線化学療法後に前・後方アプローチにより根治術を行った肺尖部胸壁浸潤肺癌の1例

杉本誠一郎, 豊岡伸一, 宗淳一, 鹿谷芳伸, 下田篤史, 山根正修, 大藤剛宏, 三好新一郎, 武本充宏, 木浦勝行

肺癌 52 ( 1 ) 109 - 110 2012.2

　 PREV - NEXT 　

< TOYOOKA Shinichi >

MISC - TOYOOKA Shinichi