研究者詳細 - 田中　真

論文 - 田中　真

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多発血管炎性肉芽腫症に合併した左上葉肺癌の1例

橋本好平, 三好健太郎, 松原慧, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 63 ( 1 ) 67 - 67 2023年2月

広範な心嚢内大血管浸潤を伴う局所進行肺がんに対して集学的治療が奏効した1例

松岡篤志, 諏澤憲, 吉川真生, 田中真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 63 ( 1 ) 74 - 74 2023年2月

広範な心嚢内大血管浸潤を伴う局所進行肺がんに対して集学的治療が奏効した1例

松岡篤志, 諏澤憲, 吉川真生, 田中真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 63 ( 1 ) 74 - 74 2023年2月

肺移植術前の骨格筋量と質、およびその待機期間中の変化と術後アウトカムの関連性

萩山明和, 杉本誠一郎, 三好健太郎, 田中真, 松原慧, 堅山佳美, 濱田全紀, 千田益生, 豊岡伸一

呼吸理学療法学 3 ( Suppl. ) 138 - 138 2023年

One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study

Kei Namba, Ken Suzawa, Kazuhiko Shien, Akihiro Miura, Yuta Takahashi, Shunsaku Miyauchi, Kota Araki, Kentaro Nakata, Shuta Tomida, Shin Tanaka, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

Scientific Reports 12 ( 1 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media {LLC}

<jats:title>Abstract</jats:title><jats:p>One-step nucleic acid amplification (OSNA) is a rapid intraoperative molecular detection technique for sentinel node assessment via the quantitative measurement of target cytokeratin 19 (<jats:italic>CK19</jats:italic>) mRNA to determine the presence of metastasis. It has been validated in breast cancer but its application in lung cancer has not been adequately investigated. 214 LNs from 105 patients with 100 primary lung cancers, 2 occult primary lung tumors, and 3 metastatic lung tumors, who underwent surgical lung resection with LN dissection between February 2018 and January 2020, were assessed. Resected LNs were divided into two parts: one was snap-frozen for OSNA and the other underwent rapidly frozen histological examination. Intraoperatively collected LNs were evaluated by OSNA using loop-mediated isothermal amplification and compared with intraoperative pathological diagnosis as a control. Among 214 LNs, 14 were detected as positive by OSNA, and 11 were positive by both OSNA and intraoperative pathological diagnosis. The sensitivity and specificity of OSNA was 84.6% and 98.5%, respectively. The results of 5 of 214 LNs were discordant, and the remainder all matched (11 positive and 198 negative) with a concordance rate of 97.7%. Although the analysis of public mRNA expression data from cBioPortal showed that <jats:italic>CK19</jats:italic> expression varies greatly depending on the cancer type and histological subtype, the results of the five cases, except for primary lung cancer, were consistent. OSNA provides sufficient diagnostic accuracy and speed and can be applied to the intraoperative diagnosis of LN metastasis for non-small cell lung cancer.</jats:p>

DOI： 10.1038/s41598-022-11064-4

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Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka

World Journal of Surgical Oncology 20 ( 1 ) 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media {LLC}

<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Soft-tissue sarcomas are rare malignancies that consist of many different histologic subtypes and arise in various locations in the body. In patients with lung metastases from retroperitoneal sarcomas, the long-term outcomes and prognostic factors are unknown. This study is a retrospective review of patients undergoing pulmonary metastasectomy for retroperitoneal sarcoma metastases at one institution, with the purpose of determining prognostic factors and clinical outcomes.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>This is a single-center, retrospective cohort study of patients undergoing pulmonary metastasectomy for lung metastases from various sarcomas at Okayama University Hospital from January 2006 to December 2018. The Kaplan-Meier method and log-rank test were used for the analyses, and cut-off values of continuous variables were determined by a receiver operating characteristic curve analysis.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>Twenty-four patients underwent the first pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma in our hospital. Leiomyosarcoma was the most common histologic subtype of retroperitoneal sarcoma (79.2%, <jats:italic>n</jats:italic> = 19). Median overall survival was 49.9 months, and the 3-year and 5-year survival rates after the first pulmonary metastasectomy were 62.5% and 26.4% respectively. In univariate analysis, age ≥56 years, disease-free interval < 15 months, and size of metastasis (≥ 27 mm) were associated with poor survival.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>Pulmonary metastasectomy can be considered as an effective management strategy in retroperitoneal sarcoma patients with lung metastases in appropriately selected cases, just as it is for other sarcomas.</jats:p>
</jats:sec>

DOI： 10.1186/s12957-022-02552-y

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Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung. 査読国際誌

Kentaro Nakata, Mikio Okazaki, Tomohisa Sakaue, Rie Kinoshita, Yuhei Komoda, Dai Shimizu, Haruchika Yamamoto, Shin Tanaka, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Toshiaki Ohara, Seiichiro Sugimoto, Masaomi Yamane, Akihiro Matsukawa, Masakiyo Sakaguchi, Shinichi Toyooka

Bioengineering (Basel, Switzerland) 9 ( 11 ) 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

(1) Background: Lung ischemia-reperfusion (IR) injury increases the mortality and morbidity of patients undergoing lung transplantation. The objective of this study was to identify the key initiator of lung IR injury and to evaluate pharmacological therapeutic approaches using a functional inhibitor against the identified molecule. (2) Methods: Using a mouse hilar clamp model, the combination of RNA sequencing and histological investigations revealed that neutrophil-derived S100A8/A9 plays a central role in inflammatory reactions during lung IR injury. Mice were assigned to sham and IR groups with or without the injection of anti-S100A8/A9 neutralizing monoclonal antibody (mAb). (3) Results: Anti-S100A8/A9 mAb treatment significantly attenuated plasma S100A8/A9 levels compared with control IgG. As evaluated by oxygenation capacity and neutrophil infiltration, the antibody treatment dramatically ameliorated the IR injury. The gene expression levels of cytokines and chemokines induced by IR injury were significantly reduced by the neutralizing antibody. Furthermore, the antibody treatment significantly reduced TUNEL-positive cells, indicating the presence of apoptotic cells. (4) Conclusions: We identified S100A8/A9 as a novel therapeutic target against lung IR injury.

DOI： 10.3390/bioengineering9110673

PubMed

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局所進行肺癌に対する集学的治療における末梢血好中球/リンパ球比(NLR)と放射線肺臓炎の関連

久保友次郎, 山本寛斉, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 勝井邦彰, 平木隆夫, 豊岡伸一

肺癌 62 ( 6 ) 704 - 704 2022年11月

子宮肉腫肺転移における腫瘍浸潤リンパ球,三次リンパ様構造,末梢血好中球リンパ球比・総リンパ球数の検討

山本寛斉, 松田直樹, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 62 ( 6 ) 622 - 622 2022年11月

Inhibiting S100A8/A9 attenuates airway obstruction in a mouse model of heterotopic tracheal transplantation

Dai Shimizu, Mikio Okazaki, Seiichiro Sugimoto, Rie Kinoshita, Kentaro Nakata, Shin Tanaka, Kohei Hashimoto, Kentaroh Miyoshi, Masaomi Yamane, Akihiro Matsukawa, Masakiyo Sakaguchi, Shinichi Toyooka

Biochemical and Biophysical Research Communications 2022年11月

Paediatric lung transplantation: the impact of age on the survival

Shinji Otani, Haruchika Yamamoto, Shin Tanaka, Yasuaki Tomioka, Kei Matsubara, Dai Shimizu, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Surgery Today 52 ( 11 ) 1540 - 1550 2022年11月

術前画像によるTis/T1肺腺癌の予後予測モデル

吉川真生, 枝園和彦, 松原慧, 田中真, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 62 ( 6 ) 711 - 711 2022年11月

サルベージ手術・コンバージョン手術・インダクション手術導入化学放射線療法後に再発を認めた非小細胞肺がん症例に対する局所治療の意義

枝園和彦, 吉川真生, 大亀正義, 橋本好平, 田中真, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一, 木浦勝行, 豊岡伸一

肺癌 62 ( 6 ) 532 - 532 2022年11月

Interrupted versus continuous suture for bronchial anastomosis in lung transplantation: does it matter?

Mariana Gil Barturen, Jose Luis Campo-Cañaveral de la Cruz, Silvana Crowley Carrasco, Alejandra Romero Román, Lucas Hoyos Mejía, María Peyró, Gema Díaz Nuevo, Cristina López García-Gallo, Marina Pérez Redondo, Ana Royuela Vicente, Shin Tanaka, Jose Manuel Naranjo Gómez, Mar Córdoba Peláez, Andrés Varela de Ugarte, David Gómez de Antonio

European Journal of Cardio-Thoracic Surgery 62 ( 5 ) 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press ({OUP})

<jats:title>Abstract</jats:title>
<jats:p />
<jats:sec>
<jats:title>OBJECTIVES</jats:title>
<jats:p>Bronchial anastomotic complications remain a major concern in lung transplantation. We aim to compare 2 different techniques, continuous suture (CS) versus interrupted suture (IS) by analysing airway complications requiring intervention.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>METHODS</jats:title>
<jats:p>Lung transplantations between January 2015 and December 2020 were included. Airway complications requiring intervention were classified following the 2018 International Society for Heart and Lung Transplantation consensus and analysed comparing 3 groups of patients according to surgical technique: group A, both anastomosis performed with CS; group B, both with interrupted; and group C, IS for 1 side and CS for the contralateral side.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS</jats:title>
<jats:p>A total of 461 anastomoses were performed in 245 patients. The incidence of airway complications requiring intervention was 5.7% [95% confidence interval (CI): 2.8–8.6] per patient (14/245) and 3.7% (95% CI: 2.0–5.4) per anastomosis (17/461). Complications that required intervention were present in 5 out of 164 (3.1%) anastomosis with interrupted technique, and in 12/240 (5%) with CS. No significant differences were found between techniques (P = 0.184). No statistical differences were found among group A, B or C in terms of incidence of anastomotic complications, demographics, transplant outcomes or overall survival (log-rank P = 0.513). In a multivariable analysis, right laterality was significantly associated to complications requiring intervention (OR 3.7 [95% CI: 1.1–12.3], P = 0.030). Endoscopic treatment was successful in 12 patients (85.7%). Retransplantation was necessary in 2 patients.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS</jats:title>
<jats:p>In summary, although it seems that anastomotic complications requiring intervention occur more frequently with CS, there are no statistical differences compared to IS. Endoscopic treatment offers good outcomes in most of the airway complications after lung transplantation.</jats:p>
</jats:sec>

DOI： 10.1093/ejcts/ezac493

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肺移植後長期予後向上への取り組み 60歳以上の高齢肺移植レシピエントにおける傾向スコアマッチングを用いた術後長期成績に関する検討

久保友次郎, 田中真, 氏家裕征, 川名伸一, 清水大, 松原慧, 富岡泰章, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

移植 57 ( 総会臨時 ) 224 - 224 2022年10月

新型コロナウイルス時代の臓器提供,臓器移植のありかた肺移植レシピエントに発症したCOVID-19の経験

川名伸一, 杉本誠一郎, 田中真, 三好健太郎, 氏家裕征, 久保友次郎, 清水大, 松原慧, 橋本好平, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 豊岡伸一

移植 57 ( 総会臨時 ) 143 - 143 2022年10月

肺グラフト評価法と保存法の現状と展望心停止ドナー肺移植におけるEx Vivo Lung Perfusionの展望

田中真, 石上恵美, 石原恵, 松原慧, 橋本好平, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

移植 57 ( 総会臨時 ) 211 - 211 2022年10月

なぜ日本の肺移植の成績は良いのか? 肺移植後の長期成績と慢性期管理

杉本誠一郎, 三好健太郎, 田中真, 松原彗, 橋本好平, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 豊岡伸一

日本胸部外科学会定期学術集会 75回 LPD1 - 5 2022年10月

日本での心停止ドナー肺移植導入に向けて、スペインでの経験を踏まえて

田中真, 石上恵美, 石原恵, 橋本好平, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹夫, 杉本誠一郎, 豊岡伸一

移植 57 ( 総会臨時 ) 338 - 338 2022年10月

Evaluation of Uncontrolled Donation After Circulatory Death Lungs by Conventional In Situ Effluent Gas Analysis and Ex Vivo Lung Perfusion

Shin Tanaka, Lucas Hoyos Mejía, Alejandra Romero Román, Jose Luis Campo-Cañaveral de la Cruz, Silvana Crowley Carrasco, Jose Manuel Naranjo Gómez, Maria del Mar Córdoba Peláez, Álvaro Sánchez Calle, Mariana Gil Barturen, Andrés Varela de Ugarte, David Gómez-de-Antonio

Archivos de Bronconeumología 58 ( 7 ) 569 - 571 2022年7月

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