研究者詳細 - 田中　真

論文 - 田中　真

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子宮肉腫肺転移における腫瘍浸潤リンパ球・三次リンパ様構造・末梢血好中球リンパ球比の検討

山本寛斉, 松田直樹, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O14 - 7 2023年6月

肺虚血再灌流障害に対する高ヒスチジン糖タンパク質(HRG)補充療法の有用性

久保友次郎, 杉本誠一郎, 調枝治樹, 氏家裕征, 川名伸一, 清水大, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O19 - 2 2023年6月

67歳の間質性肺炎に対する両側生体肺移植の経験

調枝治樹, 杉本誠一郎, 田中真, 氏家裕征, 松原慧, 橋本好平, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O18 - 2 2023年6月

慢性移植肺機能不全(CLAD)に対する再肺移植の術式と長期成績

杉本誠一郎, 調枝治樹, 氏家裕征, 川名伸一, 久保友次郎, 松原慧, 田中真, 橋本好平, 諏澤憲, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O18 - 4 2023年6月

肺移植レシピエントにおけるSARS-CoV-2ワクチン追加接種の有効性の検討

川名伸一, 杉本誠一郎, 松原慧, 田中真, 三好健太郎, 調枝治樹, 氏家裕征, 久保友次郎, 清水大, 橋本好平, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O17 - 2 2023年6月

Pulmonary alveolar proteinosis after lung transplantation: Two case reports and literature review. 国際誌

Shinichi Kawana, Kentaroh Miyoshi, Shin Tanaka, Seiichiro Sugimoto, Dai Shimizu, Kei Matsubara, Mikio Okazaki, Noboru Hattori, Shinichi Toyooka

Respirology case reports 11 ( 6 ) e01160 2023年6月

記述言語：英語

Pulmonary alveolar proteinosis (PAP) affecting transplanted lungs is not well recognized. Herein, we report two cases of PAP after lung transplantation (LTx). The first case was a 4-year-old boy with hereditary pulmonary fibrosis who underwent bilateral LTx and presented with respiratory distress on postoperative day (POD) 23. He was initially treated for acute rejection, died due to infection on POD 248, and was diagnosed with PAP at autopsy. The second case involved a 52-year-old man with idiopathic pulmonary fibrosis who underwent bilateral LTx. On POD 99, chest computed tomography revealed ground-glass opacities. Bronchoalveolar lavage and transbronchial biopsy led to a diagnosis of PAP. Follow-up with immunosuppression tapering resulted in clinical and radiological improvement. PAP after lung transplantation mimics common acute rejection; however, is potentially transient or resolved with tapering immunosuppression, as observed in the second case. Transplant physicians should be aware of this rare complication to avoid misconducting immunosuppressive management.

DOI： 10.1002/rcr2.1160

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子宮肉腫肺転移における腫瘍浸潤リンパ球・三次リンパ様構造・末梢血好中球リンパ球比の検討

山本寛斉, 松田直樹, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O14 - 7 2023年6月

術後46年で胸膜播種再発をきたした無巨核球性血小板減少を伴う赤芽球癆と重症筋無力症合併胸腺腫の一切除例

梅田将志, 諏澤憲, 田中真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) P69 - 3 2023年6月

多発肋骨骨折に対する金属ワイヤ固定の工夫 Twisted wire splint法

柳光剛志, 三好健太郎, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) P30 - 3 2023年6月

椎体浸潤を伴う非小細胞肺癌に対する術前導入化学放射線療法後手術症例の治療成績の検討

林直宏, 山本寛斉, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) O8 - 2 2023年6月

術後46年で胸膜播種再発をきたした無巨核球性血小板減少を伴う赤芽球癆と重症筋無力症合併胸腺腫の一切除例

梅田将志, 諏澤憲, 田中真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) P69 - 3 2023年6月

多発肋骨骨折に対する金属ワイヤ固定の工夫 Twisted wire splint法

柳光剛志, 三好健太郎, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本呼吸器外科学会雑誌 37 ( 3 ) P30 - 3 2023年6月

S100A8/A9 as a prognostic biomarker in lung transplantation. 国際誌

Kentaro Nakata, Mikio Okazaki, Shinichi Kawana, Yujiro Kubo, Dai Shimizu, Shin Tanaka, Kohei Hashimoto, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Shinichi Toyooka

Clinical transplantation e15006 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: S100A8/A9 is a damage-associated molecule that augments systemic inflammation. However, its role in the acute phase after lung transplantation (LTx) remains elusive. This study aimed to determine S100A8/A9 levels after lung transplantation (LTx) and evaluate their impact on overall survival (OS) and chronic lung allograft dysfunction (CLAD)-free survival. METHODS: Sixty patients were enrolled in this study, and their plasma S100A8/A9 levels were measured on days 0, 1, 2, and 3 after LTx. The association of S100A8/A9 levels with OS and CLAD-free survival was assessed using univariate and multivariate Cox regression analyses. RESULTS: S100A8/A9 levels were elevated in a time-dependent manner until 3 days after LTx. Ischemic time was significantly longer in the high S100A8/9 group than in the low S100A8/A9 group (p = .017). Patients with high S100A8/A9 levels (> 2844 ng/mL) had worse prognosis (p = .031) and shorter CLAD-free survival (p = .045) in the Kaplan-Meier survival analysis than those with low levels. Furthermore, multivariate Cox regression analysis showed that high S100A8/A9 levels were a determinant of poor OS (hazard ratio [HR]: 3.7; 95% confidence interval [CI]: 1.2-12; p = .028) and poor CLAD-free survival (HR: 4.1; 95% CI: 1.1-15; p = .03). In patients with a low primary graft dysfunction grade (0-2), a high level of S100A8/A9 was also a poor prognostic factor. CONCLUSIONS: Our study provided novel insights into the role of S100A8/A9 as a prognostic biomarker and a potential therapeutic target for LTx.

DOI： 10.1111/ctr.15006

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Diagnostic value of circulating microRNA-21 in chronic lung allograft dysfunction after bilateral cadaveric and living-donor lobar lung transplantation

Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Haruchika Yamamoto, Shin Tanaka, Kentaroh Miyoshi, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

Heliyon 2023年4月

脳死両肺移植後患者における血栓性微小血管障害症(Thorombotic microangiopathy:TMA)

柳光剛志, 三好健太郎, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

移植 57 ( 4 ) 415 - 415 2023年4月

非小細胞肺がんにおける腫瘍免疫状態指標としての好中球・リンパ球比(NLR)の有用性

岩田一馬, 諏澤憲, 松原慧, 橋本好平, 田中真, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

日本外科学会定期学術集会抄録集 123回 DP - 2 2023年4月

Donor's long‐term quality of life following living‐donor lobar lung transplantation 国際誌

Kento Fujii, Shin Tanaka, Megumi Ishihara, Kei Matsubara, Kohei Hashimoto, Shuji Okahara, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Clinical Transplantation 37 ( 4 ) e14927 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Living-donor lobar lung transplantation is an alternative procedure to deceased donation lung transplantation. It involves graft donation from healthy donors; however, only a few reports have discussed its long-term prognosis in living lung donors and their associated health-related quality of life. This study aimed to examine living lung donors' health-related quality of life. METHODS: In our cross-sectional survey of living lung donors, we assessed health-related quality of life-based on three key aspects (physical, mental, and social health) using the 36-Item Short Form Health Survey. We also evaluated chronic postoperative pain and postoperative breathlessness using the numeric rating scale and the modified Medical Research Council Dyspnea scale, respectively. RESULTS: We obtained consent from 117 of 174 living lung donors. The average scores of the living lung donors on the 36-Item Short Form Health Survey were higher than the national average. However, some donors had poorer physical, mental, and social health, with lower summary scores than the national averages. Low mental component summary predictors included donor age (<40 years; odds ratio = 10.2; p < .001) and recipient age (<18 years; odds ratio = 2.73; p < .032). Low role-social component summary predictors included high lung allocation score (≥50; odds ratio = 3.94, p < .002) and recipient death (odds ratio = 3.64; p = .005). There were no predictors for a physical component summary. Additionally, many donors did not complain of pain or dyspnea. CONCLUSIONS: Living lung donors maintained an acceptable long-term health-related quality of life after surgery. Potential donors should be informed of relevant risk factors, and high-risk donors should receive appropriate support.

DOI： 10.1111/ctr.14927

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待機中に二次性肺高血圧を発症した特発性肺線維症に対する脳死左片肺移植術

調枝治樹, 三好健太郎, 清水大, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

移植 57 ( 4 ) 394 - 394 2023年4月

脳死両肺移植後CLADによる高炭酸ガス血症に対する治療戦略:日中のリハビリテーションと夜間の人工呼吸器管理

調枝治樹, 田中真, 松原慧, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

移植 57 ( 4 ) 338 - 338 2023年4月

超音波手術器を用いて胸腔鏡下に切除した肋骨腫瘍の1例

氏家裕征, 山本寛斉, 松原慧, 田中真, 橋本好平, 諏澤憲, 枝園和彦, 岡崎幹生, 杉本誠一郎, 豊岡伸一

肺癌 63 ( 1 ) 66 - 66 2023年2月

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